Genomes and Genes
Gene Symbol: OPN1LW
Description: opsin 1 (cone pigments), long-wave-sensitive
Alias: CBBM, CBP, COD5, RCP, ROP, cone dystrophy 5 (X-linked), long-wave-sensitive opsin 1, red cone photoreceptor pigment, red-sensitive opsin
Publications149 found, 100 shown here
- Expression of cAMP response element binding protein-binding protein in the song control system and hypothalamus of adult European starlings (Sturnus vulgaris)C J Auger
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore MD 21218 2686, USA
J Neuroendocrinol 14:805-13. 2002..The coactivator, cAMP response element binding protein (CREB)-binding protein (CBP), has been implicated in both androgen and oestrogen receptor transactivation...
- Prognostic superiority of daytime ambulatory over conventional blood pressure in four populations: a meta-analysis of 7,030 individualsTine W Hansen
Research Center for Prevention and Health, Copenhagen, Denmark
J Hypertens 25:1554-64. 2007To investigate the multivariate-adjusted predictive value of systolic and diastolic blood pressures on conventional (CBP) and daytime (10-20 h) ambulatory (ABP) measurement.
- Comparison of chain- and plate-loaded bench press training on strength, joint pain, and muscle soreness in Division II baseball playersKevin McCurdy
Department of Health Physical Education and Recreation, Texas State University, San Marcos, Texas, USA
J Strength Cond Res 23:187-95. 2009The purpose of this study was to investigate the effects of chain- (CBP) and plate-loaded (PBP) bench press training on measures of strength, shoulder pain, and muscle soreness in Division II baseball players...
- Rational design of cyclic peptide modulators of the transcriptional coactivator CBP: a new class of p53 inhibitorsGuillermo Gerona-Navarro
Department of Structural and Chemical Biology, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1677, New York, New York 10029, United States
J Am Chem Soc 133:2040-3. 2011The CREB binding protein (CBP) is a human transcriptional coactivator consisting of several conserved functional modules, which interacts with distinct transcription factors including nuclear receptors, CREB, and STAT proteins...
- LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIFKatherine A Fitzgerald
Division of Infectious Disease and Immunology, Department of Medicine, The University of Massachusetts Medical School, Worcester, MA 01605, USA
J Exp Med 198:1043-55. 2003..These studies suggest that TRIF and TRAM both function in LPS-TLR4 signaling to regulate the MyD88-independent pathway during the innate immune response to LPS...
- Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12K Ito
Thoracic Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, London, United Kingdom
Mol Cell Biol 20:6891-903. 2000..Furthermore, we show that GR acts both as a direct inhibitor of CREB binding protein (CBP)-associated HAT activity and also by recruiting HDAC2 to the p65-CBP HAT complex...
- Protein coregulators that mediate estrogen receptor functionT Ratajczak
Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia
Reprod Fertil Dev 13:221-9. 2001..of selected members of the multifunctional steroid receptor coactivator family and the cointegrators, p300/CBP and P/CAF...
- Against women: are we looking after our general practitioners? GPs' views of the 1990 part-time contractJ Littlewood
South Bank University, London
J R Soc Promot Health 119:85-8. 1999..This particularly affects women General Practitioners. Whilst the RCP policy statement addresses education and training for general practice, the question of not losing out in relation ..
- 1,25-Dihydroxyvitamin D3 stimulates cyclic vitamin D receptor/retinoid X receptor DNA-binding, co-activator recruitment, and histone acetylation in intact osteoblastsSungtae Kim
Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
J Bone Miner Res 20:305-17. 2005....
- Temporal formation of distinct thyroid hormone receptor coactivator complexes in HeLa cellsD Sharma
Department of Physiology, University of Maryland School of Medicine, Baltimore 21201, USA
Mol Endocrinol 14:2001-9. 2000..Coactivators implicated in ligand-dependent activation by TR include p300, the CREB-binding protein (CBP), members of the p160/SRC family, and the multisubunit TR-associated protein (TRAP) complex...
- Treatment of hypertensive patients according to the conventional or ambulatory pressure: a progress report on the APTH trial. APTH Investigators. Ambulatory Blood Pressure and Treatment of HypertensionL Bieniaszewski
Klinisch Laboratorium Hypertensie, Inwendige Geneeskunde Cardiologie U Z Gasthuisberg
Acta Cardiol 51:243-51. 1996..sitting diastolic pressure from 80 through 89 mm Hg on conventional sphygmomanometry (conventional blood pressure [CBP] group), and one in which a daytime (from 10 to 20 h) diastolic pressure from 80 through 89 mm Hg had to be ..
- Empiric antibiotics are justified for infants with respiratory syncytial virus lower respiratory tract infection presenting with respiratory failure: a prospective study and evidence reviewDaniel Levin
Department of Pediatrics, Children s Hospital at Dartmouth, Dartmouth Medical School, Lebanon, NH, USA
Pediatr Crit Care Med 11:390-5. 2010..We hypothesized the composite diagnosis of concomitant bacterial pneumonia (CBP) is common in lower risk infants with RSV who present in respiratory failure...
- [Effect of continuous blood purification and thymosin alpha1 on the cellular immunity in patients with severe sepsis: a prospective, randomized, controlled clinical trial]Yi Nan Li
Intensive Care Unit, the First Hospital of Foshan, Foshan 528000, Guangdong, China
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21:139-42. 2009To discuss the effect of continuous blood purification (CBP), thymosin alpha1 and combined therapy on cellular immunity in patients with severe sepsis.
- In vivo complex formation of PU.1 with HDAC1 associated with PU.1-mediated transcriptional repressionF Kihara-Negishi
Department of Cell Genetics, Sasaki Institute, 2 2, Kanda Surugadai, Chiyoda ku, Tokyo 101 0062, Japan
Oncogene 20:6039-47. 2001..It was unlikely that the repression was due to sequestration of a limited amount of CBP/p300 nor pCAF, because overexpression of these co-activators did not relieve PU...
- Home blood pressure normalcy: the Didima studyG S Stergiou
Hypertension Center, Third University Department of Medicine, Sotiria Hospital, Athens, Greece
Am J Hypertens 13:678-85. 2000..4%). Clinic blood pressure (CBP) was measured on two visits (triplicate measurements, mercury sphygmomanometer) and HBP on 3 workdays (duplicate ..
- Protective effect of Weikang decoction and partial ingredients on model rat with gastric mucosa ulcerTuo Ying Fan
Shenzhen Donghu Hospital, Shenzhen 518020, Guangdong Province, China
World J Gastroenterol 11:1204-9. 2005..To investigate the protective mechanisms of Weikang (WK) decoction on gastric mucosae...
- Gene amplification and expression of the steroid receptor coactivator SRC3 (AIB1) in sporadic breast and endometrial carcinomasM Glaeser
Department of Gynecology and Obstetrics, Heinrich-Heine-University, Duesseldorf, Germany
Horm Metab Res 33:121-6. 2001..It binds to nuclear receptors in a ligand-dependent fashion and recruits other factors such as CBP and p300 to the transactivation complex...
- [Determining factors in decisions regarding cardio-pulmonary resuscitation in patients with cerebral hemorrhage]J R Ara
, Hospital Miguel Servet, Zaragoza,
Rev Neurol 25:1518-20. 1997..RESULTS: We identified 73 patients, 50 men and 23 women. Their mean age was 61 years. RCP was performed in 25 patients (34%). A logistic regression revealed that age (OR 0...
- Stability of YACs containing ribosomal or RCP/GCP locus DNA in wild-type S. cerevisiae and RAD mutant strainsK Kohno
Department of Molecular and Cellular Biology for Pharmaceutical Sciences, Kyoto Pharmaceutical University, Japan
DNA Res 1:191-9. 1994....
- Rubinstein-Taybi syndrome with epidermal nevus: a case reportC Schepis
Unit of Dermatology and Department of Pediatrics, Oasi Institute (IRCCS, Troina, Italy
Pediatr Dermatol 18:34-7. 2001..facies, and mental retardation caused by mutations in the transcriptional coactivator CREB binding protein (CBP)...
- [Correlation between XRCC2 and XRCC5 single nucleotide polymorphisms and drug-sensitivity of human lung cancer cells]Rui Wang
Department of Thoracic Surgery, Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang 050011, China
Zhonghua Yi Xue Za Zhi 88:3059-62. 2008..To study the associations between XRCC2 and XRCC5 single nucleotide polymorphisms (SNPs) and chemosensitivity of human lung cancer cells...
- Corn expressing an Escherichia coli-derived phytase gene: comparative evaluation study in broiler chicksE K D Nyannor
Department of Animal Science, Purdue University, West Lafayette, IN 47907 2054, USA
Poult Sci 87:2015-22. 2008The efficacy of corn expressing an Escherichia coli-derived gene (corn-based phytase; CBP) and an E...
- The international atom: evolution of radiation control programsF J Bradley
Health Phys 83:121-34. 2002..pool reactor in 1962 that initiated a health physics program for the reactor and a Radiation Control Program (RCP) for the country's use of ionizing radiation...
- Transactivation mechanisms of mouse clock transcription factors, mClock and mArnt3S Takahata
Department of Chemistry, Graduate School of Science, Tohoku University, Aoba-ku, Sendai 980-8578, Japan
Genes Cells 5:739-47. 2000..Yeast and mammalian two-hybrid systems revealed that CBP and p300 interacted with mArnt3 via the CREB binding domain...
- Clinical analysis of 43 cases of chronic benzene poisoningShouren Kuang
Guangdong Poison Control Center, 165 Xin gang Road, Guangzhou 510300, PR China
Chem Biol Interact 153:129-35. 2005Benzene can result in bone marrow suppression. Chronic benzene poisoning (CBP) can be found among workers with excessive benzene exposure...
- In-house preparation of technetium 99m-labeled human serum albumin for evaluation of protein-losing gastroenteropathyJoseph C Hung
Nuclear Pharmacy Laboratories and PET Radiochemistry Facility, Department of Radiology, Mayo Clinic, Rochester, Minn 55905 0001, USA
J Am Pharm Assoc (Wash) 42:57-62. 2002..To develop an in-house preparation method for technetium 99m-labeled human serum albumin (99mTc-HSA) to meet the clinical need for gastrointestinal (GI) protein loss evaluation in our institution...
- Characterisation of cellulose-binding proteins that are involved in the adhesion mechanism of Fibrobacter intestinalis DR7J Miron
Metabolic Unit, Volcani Center, Bet Dagan, Israel
Appl Microbiol Biotechnol 51:491-7. 1999Cellulose-binding proteins (CBP) isolated from cell envelopes of the cellulolytic bacterium Fibrobacter intestinalis strain DR7 were studied in order to investigate the adhesion mechanism...
- SUMO-1-dependent allosteric regulation of thymine DNA glycosylase alters subnuclear localization and CBP/p300 recruitmentRyan D Mohan
Department of Physiology and Pharmacology, Siebens Drake Medical Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada N6G 2V4
Mol Cell Biol 27:229-43. 2007..enzyme thymine DNA glycosylase (TDG) mediates recruitment of histone acetyltransferases CREB-binding protein (CBP) and p300 to DNA, suggesting a plausible role for these factors in TDG-mediated repair...
- Occlusal changes following posterior tooth loss in adults. Part 3. A study of clinical parameters associated with the presence of occlusal interferences following posterior tooth lossHelen L Craddock
Restorative Dentistry, Leeds Dental Institute, Clarendon Way, Leeds, UK
J Prosthodont 17:25-30. 2008..The purpose of this study was to determine clinical parameters associated with the presence of retruded contact position (RCP) contacts and occlusal interferences associated with posterior tooth loss.
- Rab coupling protein (RCP): a novel target of progesterone action in primate endometriumV S Patil
Primate Biology Department, National Institute for Research in Reproductive Health, Indian Council of Medical Research, Parel, Mumbai 400 012, India
J Mol Endocrinol 35:357-72. 2005..DD2 sequence was found to be homologous to the sequence of the carboxyl terminal region of Rab coupling protein (RCP), a recently discovered protein involved in intracellular vesicular trafficking...
- Analysis of occlusal contacts in different types of prosthodontic appliances, Eichner classifications, presence RCP-ICP slide and the type of occlusionJ Stipetić
Department of Prosthodontic, School of Dental Medicine, University of Zagreb, Croatia
Coll Antropol 25:311-6. 2001..weak) with respect to the type of occlusion (canine guided, group function or balanced) and the presence of the RCP-ICP slide...
- Properties of cattle bone powder-coated composite particles as high-performance and open column liquid chromatographic column packingsF Honda
PHD Inc, Hokkaido, Japan
J Chromatogr A 813:21-33. 1998Cattle bone powder (CBP) from natural resources was employed as a protein adsorbent instead of chemically synthesized hydroxyapatite (HA). Though a small amount of impurities was detected, CBP possessed a crystallinity similar to HA...
- Corn expressing an Escherichia coli-derived phytase gene: a proof-of-concept nutritional study in pigsE K D Nyannor
Department of Animal Science, Purdue University, West Lafayette, IN 47907 2054, USA
J Anim Sci 85:1946-52. 2007..investigate the concept that the addition of corn expressing an Escherichia coli-derived gene (corn-based phytase; CBP) to a P-deficient diet would improve growth performance and P utilization in pigs. An E...
- Role of the transcriptional coactivator CBP/p300 in linking basic helix-loop-helix and CREB responses for follicle-stimulating hormone-mediated activation of the transferrin promoter in Sertoli cellsJ Chaudhary
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
Biol Reprod 65:568-74. 2001..Such an interaction can be mediated by transcriptional integrators such as CREB-binding protein (CBP) and/or p300 and may stabilize the binding of trans-acting factors to their respective cis-elements...
- Synergistic antifungal activity of two chitin-binding proteins from spindle tree (Euonymus europaeus L.)Karolien P B Van den Bergh
Laboratory of Phytopathology and Plant Protection, Katholieke Universiteit Leuven, Willem de Croylaan 42, 3001 Leuven, Belgium
Planta 219:221-32. 2004..Both the small hevein-like chitin-binding protein (Ee-CBP) and the classical class-I chitinase (Ee-chitinase) possess antifungal properties, Ee-CBP being far more potent ..
- Cell separation based on the reversible interaction between calmodulin and a calmodulin-binding peptideR J Colinas
The Wadsworth Center, New York State Department of Health, Albany 12201 0509, USA
J Immunol Methods 212:69-78. 1998..separation system based on the calcium-dependent interaction of calmodulin (CM) with a calmodulin-binding peptide (CBP) has been developed. The prototype of this system utilizes an indirect method to label the target cell population...
- [Penetrability of amikacin into prostate tissues in rat models of chronic bacterial prostatitis]He Wang
Department of Microbiology, Guiyang Medical College, Guiyang, Guizhou 550004, China
Zhonghua Nan Ke Xue 14:583-9. 2008..To establish the rat model of chronic bacterial prostatitis and investigate the penetrability of amikacin to chronic inflammatory prostatic tissues...
- E1A-mediated repression of progesterone receptor-dependent transactivation involves inhibition of the assembly of a multisubunit coactivation complexY Xu
Population Council, The Rockefeller University, New York, New York 10021, USA
Mol Cell Biol 20:2138-46. 2000..a multisubunit receptor-coactivator complex containing two previously described coactivators, CREB-binding protein (CBP) and steroid receptor coactivator 1 (SRC-1, a member of the p160 family of coactivators), in nuclear extracts of ..
- Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear specklesS Chakraborty
Department of Pathology and The Cancer Center, University of Illinois at Chicago, Chicago, Illinois 60607, USA
J Biol Chem 276:44936-43. 2001..The second group includes the two co-activators cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF), both of which have histone acetyltransferase (HAT) activity...
- Expression of steroid receptor coactivators and corepressors in human endometrial hyperplasia and carcinoma with relevance to steroid receptors and Ki-67 expressionJunko Uchikawa
Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
Cancer 98:2207-13. 2003..as coactivators (steroid receptor coactivator 1 [SRC-1] and p300/cyclic AMP-response element-binding protein (p300/CBP]) and corepressors (nuclear receptor corepressor [NCoR] and silencing mediator for retinoid and thyroid-hormone ..
- NF-kappaB/PPAR gamma and/or AP-1/PPAR gamma 'on/off' switches and induction of CBP in colon adenocarcinomas: correlation with COX-2 expressionPanagiotis A Konstantinopoulos
Department of Biochemistry, School of Medicine, University of Patras, 26110, Patras, Greece
Int J Colorectal Dis 22:57-68. 2007..a signaling intermediate of NF-kappaB pathway), PPAR gamma, cyclic AMP-response element binding-binding protein (CBP, a known AP-1, NF-kappaB, and PPAR gamma transcriptional coactivator), epidermal growth factor receptor (EGF-R), ..
- Clinical application of retrograde cerebral perfusion for brain protection during surgery of ascending aortic aneurysm--a report of 50 casesPeiqing Dong
J Extra Corpor Technol 34:101-6. 2002..To protect the brain, deep hypothermic circulatory arrest (DHCA) combined with retrograde cerebral perfusion (RCP) through superior vena cava (N = 50) and simple DHCA (N = 15) were used during the procedure...
- Acetylation of importin-alpha nuclear import factors by CBP/p300A J Bannister
Department of Pathology, Wellcome CRC Institute, University of Cambridge, Cambridge, CB2 1QR, UK
Curr Biol 10:467-70. 2000..We asked whether the acetylase CREB-binding protein (CBP) could acetylate proteins not directly involved in transcription...
- cAMP-response-element-binding-protein-binding protein (CBP) and p300 are transcriptional co-activators of early growth response factor-1 (Egr-1)E S Silverman
Vascular Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
Biochem J 336:183-9. 1998..The transcriptional co-activators CBP (cAMP-response-element-binding-protein-binding protein) and p300 interact with sequence-specific transcription ..
- Assessing neuromuscular block at the larynx: the effect of change in resting cuff pressure and a comparison with video imaging in anesthetized humansK J Girling
University Department of Anaesthesia, University Hospital, Queen s Medical Centre, Nottingham, United Kingdom
Anesth Analg 88:426-31. 1999..In this study, we evaluated the decrease in resting cuff pressure (RCP) after the administration of rocuronium and the effect of this decrease on the assessment of NMB, and we compared ..
- Characterization of the complement inhibitory function of rhesus rhadinovirus complement control protein (RCP)Marcin Okroj
Department of Laboratory Medicine, Lund University, University Hospital Malmo, Malmo S 20502, Sweden
J Biol Chem 284:505-14. 2009..follows: Kaposi sarcoma-associated herpesvirus-complement control protein (KCP) and RRV-complement control protein (RCP). Previously we characterized in detail the functional properties of KCP as a complement inhibitor...
- Association between dorsolateral prefrontal N-acetyl aspartate and depression in chronic back pain: an in vivo proton magnetic resonance spectroscopy studyI D Grachev
Schering Plough Research Institute, Kenilworth, NJ 07033 0539, USA
J Neural Transm 110:287-312. 2003..Inventory), and pain (as measured by short form of the McGill Pain Questionnaire) in 10 chronic back pain (CBP) patients with depression, and compared to the relationship between regional brain NAA levels and depression in 10 ..
- Nuclear receptors have distinct affinities for coactivators: characterization by fluorescence resonance energy transferG Zhou
Department of Biochemistry and Physiology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
Mol Endocrinol 12:1594-604. 1998..in FRET between the fluorescently labeled LBD and fluorescently labeled coactivators [CREB-binding protein (CBP) or steroid receptor coactivator-1 (SRC-1)]...
- Expression of cAMP response element binding protein (CREB)-binding protein (CBP) and the implication in retinoic acid-inducible transcription activation in human salivary gland adenocarcinoma cell line HSGS Kyakumoto
Department of Biochemistry, Iwate Medical University School of Dentistry, Chuodori, Morioka, Iwate, Japan
Endocr Res 29:277-89. 2003..interacts with a coactivator complex composed of various transcription cofactors such as CREB-binding protein (CBP)/p300 and p160 family member proteins represented by steroid receptor coactivator-1 (SRC-1)/NCoA1 and p300/CBP ..
- The transcriptional regulator CBP has defined spatial associations within interphase nucleiKirk J McManus
Department of Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada
PLoS Comput Biol 2:e139. 2006..The CREB-binding protein (CBP) is one such transcriptional regulator that, when visualised by confocal microscopy, reveals a highly punctate ..
- Utilization of oil by-product from the purification process of conjugated linoleic Acid as feeding supplements for the accumulation of conjugated linoleic acid in the egg yolkJ H Kim
Department of Food and Biotechnology, Korea University, Chungnam, Korea
Poult Sci 87:64-70. 2008..The CLA by-product (CBP) was fed to the laying hens to accumulate CLA in the egg yolk...
- The relevance and recognition of Latin American science. Introduction to the fourth issue of CBP-Latin AmericaMarcelo Hermes-Lima
Oxyradical Research Group, Departamento de Biologia Celular, Universidade de Brasilia, Brasilia, DF, 70910 900, Brazil
Comp Biochem Physiol C Toxicol Pharmacol 146:1-9. 2007..is to verify which of these interpretations best applies for the field of comparative biochemistry and physiology (CBP)...
- Identification of Legionella pneumophila rcp, a pagP-like gene that confers resistance to cationic antimicrobial peptides and promotes intracellular infectionM Robey
Department of Microbiology Immunology, Northwestern University Medical School, Chicago, Illinois 60611, USA
Infect Immun 69:4276-86. 2001..resistance to different structural classes of CAMPs compared to the wild type; hence, this gene was designated rcp for resistance to cationic antimicrobial peptides...
- Respiratory compensation point during incremental exercise as related to hypoxic ventilatory chemosensitivity and lactate increase in manN Takano
Physiology Laboratory, Department of School Health, Faculty of Education, Kanazawa University, Kanazawa, 920 1192 Japan
Jpn J Physiol 50:449-55. 2000..lower VO2, termed the ventilatory threshold (VT); and another at a higher VO2, the respiratory compensation point (RCP)...
- Minilaparotomy radical cystoprostatectomy (Minilap RCP) in the surgical management of urinary bladder carcinoma: early experienceSudhir Rawal
Department of Uro Oncology, Rajiv Gandhi Cancer Institute and Research Center, Rohini, New Delhi 110085, India
Jpn J Clin Oncol 38:611-6. 2008To assess the feasibility of minilaparotomy for radical cystoprostatectomy (RCP) and urinary diversion in the management of urinary bladder carcinoma.
- [Cysteamine attenuates suppression of peripheral IL-2 and lymphocytic proliferation induced by ruminal and duodenal operations in goats]Zan Ming Shen
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China
Shi Yan Sheng Wu Xue Bao 37:501-6. 2004..pre-Op), which contained 3 d of roughage-fed period (RP) and 10 d of roughage + concentrate-fed period (RCP), followed by first operation (Op-1) and then the second operation (Op-2)...
- HDAC inhibition modulates hippocampus-dependent long-term memory for object location in a CBP-dependent mannerJakob Haettig
Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California 92697 3800, USA
Learn Mem 18:71-9. 2011..enzymes, such as the histone acetyltransferase (HAT) CREB (cyclic-AMP response element binding) binding protein (CBP), are pivotal for the transcriptional regulation required for long-term memory...
- Regulation of the human P450scc gene by steroidogenic factor 1 is mediated by CBP/p300D Monte
Laboratory of Molecular Endocrinology, CHUL Research Centre and Laval University, Sainte Foy, Quebec, G1V 4G2, Canada
J Biol Chem 273:4585-91. 1998..reporter constructs which responded to SF-1 were further stimulated by exogenous p300 and CREB-binding protein (CBP), suggesting interaction between SF-1 and p300/CBP...
- Inactivation of mRNA cap-binding protein complex in Drosophila melanogaster embryos under heat shockJ M Zapata
Centro de Biologia Molecular, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
J Biol Chem 266:16007-14. 1991We have studied the role of Drosophila 35-kDa cap-binding protein (CBP) and CBP complex in the mechanism of messenger RNA discrimination established in heat-shocked Drosophila embryos...
- Spatial memory consolidation is associated with induction of several lysine-acetyltransferase (histone acetyltransferase) expression levels and H2B/H4 acetylation-dependent transcriptional events in the rat hippocampusOlivier Bousiges
INSERM, U692, Laboratoire de Signalisations Moléculaires et Neurodégénérescence, Strasbourg, France
Neuropsychopharmacology 35:2521-37. 2010Numerous genetic studies have shown that the CREB-binding protein (CBP) is an essential component of long-term memory formation, through its histone acetyltransferase (HAT) function...
- The calcium binding proteins calbindin, parvalbumin, and calretinin have specific patterns of expression in the gray matter of cat spinal cordRoberta Anelli
Department of Physiology, Northwestern Feinberg School of Medicine, Chicago, Illinois, USA
J Neurocytol 34:369-85. 2005..However, knowledge on the cellular regulation governing such cell-specific CBP expression is still incomplete...
- Anti-inflammatory and antimicrobial effects of garlic and synergistic effect between garlic and ciprofloxacin in a chronic bacterial prostatitis rat modelDong Wan Sohn
Department of Urology, College of Medicine, The Catholic University of Korea, St Mary s Hospital, 62 Youido dong, Youngdungpoku, Seoul 150 713, South Korea
Int J Antimicrob Agents 34:215-9. 2009Chronic bacterial prostatitis (CBP), which is characterised by recurrent urinary tract infection (UTI) and persistence of pathogenic bacteria and evidence of inflammation in the prostatic secretions, is one of the most common causes of ..
- Exposure to cadmium and conventional and ambulatory blood pressures in a prospective population study. Public Health and Environmental Exposure to Cadmium Study GroupJ A Staessen
Hypertensie en Cardiovasculaire Revalidatie Eenheid, Departement voor Cardiovasculair en Moleculair Onderzoek, Katholieke Universiteit Leuven, Belgium
Am J Hypertens 13:146-56. 2000..follow-up (1991 to 1995; re-examination rate, 81%), blood pressure was measured by conventional sphygmomanometry (CBP; 15 readings in total) and, at follow-up, also by 24-h ambulatory blood pressure monitoring (ABP)...
- Distinct embryonic expression and localization of CBP and p300 histone acetyltransferases at the mouse alphaA-crystallin locus in lensYing Yang
Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA
J Mol Biol 369:917-26. 2007..Here, we identified CREB-binding protein (CBP) and p300 as major histone acetyltransferases (HATs) associated in vivo with the mouse alphaA-crystallin locus...
- Complementation analysis and regulation of CO2 fixation gene expression in a ribulose 1,5-bisphosphate carboxylase-oxygenase deletion strain of Rhodospirillum rubrumD L Falcone
Department of Microbiology, Ohio State University, Columbus 43210 1192
J Bacteriol 175:5066-77. 1993..rubrum DNA fragments that contain the gene encoding RubisCO, cbbM. When the R. rubrum cbbM deletion strain harbored plasmids containing R. rubrum DNA inserts with at least 2...
- Variation in microdeletions of the cyclic AMP-responsive element-binding protein gene at chromosome band 16p13.3 in the Rubinstein-Taybi syndromeR I Blough
Children s Hospital Research Foundation, Division of Human Genetics, Cincinnati, OH 45229 1933, USA
Am J Med Genet 90:29-34. 2000Most reported microdeletions of the CREB-binding protein (CBP) gene in the Rubinstein-Taybi syndrome (RTS) were detected by fluorescence in situ hybridization (FISH) with a single cosmid probe specific to the 3' region of the gene...
- [Comparison and reproducibility of 4 methods of indirect blood pressure measurement in moderate hypertension]T Denolle
Cabinet de Cardiologie, Dinard
Arch Mal Coeur Vaiss 88:1165-70. 1995..repeated automatic BP measurements during the 20 minutes preceding the physician examination (RABP) and clinic BP (CBP) with a standard sphygmomanometer mercury column...
- E2A proteins enhance the histone acetyltransferase activity of the transcriptional co-activators CBP and p300Brandy D Hyndman
Department of Pathology and Molecular Medicine, Queen s University, Canada
Biochim Biophys Acta 1819:446-53. 2012..CREB binding protein (CBP) and its close paralog p300 are transcriptional co-activators with intrinsic histone acetyltransferase (HAT) ..
- Use of the reciprocal calculation procedure for setting workplace emergency action levels for hydrocarbon mixtures and their relationship to lower explosive limitsRon Gardner
Hawkes Associates, for the Energy Institute, 61 New Cavendish Street, London W1G 7AR, UK
Ann Occup Hyg 56:326-39. 2012This paper proposes a novel use of the reciprocal calculation procedure (RCP) to calculate workplace emergency action levels (WEALs) for accidental releases of hydrocarbon mixtures...
- CREB-binding proteins (CBP) as a transcriptional coactivator of GATA-2HuiJie Jiang
College of Life Sciences, Ludong University, Yantai, 264025, China
Sci China C Life Sci 51:191-8. 2008..CREB-binding proteins (CBP) are essential transcriptional coactivators for a large number of regulated DNA-binding transcription factors, ..
- Inhibition of the acetyltransferases p300 and CBP reveals a targetable function for p300 in the survival and invasion pathways of prostate cancer cell linesFrédéric R Santer
Department of Urology, Experimental Urology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
Mol Cancer Ther 10:1644-55. 2011..In prostate cancer, the HATs and coactivators p300 and CBP are upregulated and may induce transcription of androgen receptor (AR)-responsive genes, even in the absence or ..
- Genome-wide assessment of differential roles for p300 and CBP in transcription regulationYolande F M Ramos
Department of Molecular Cell Biology, Leiden University Medical Center, Postzone S4 0P, PO Box 9600, 2300 RC Leiden, The Netherlands
Nucleic Acids Res 38:5396-408. 2010Despite high levels of homology, transcription coactivators p300 and CREB binding protein (CBP) are both indispensable during embryogenesis. They are largely known to regulate the same genes...
- Assessment of long-term antihypertensive treatment by clinic and ambulatory blood pressure: data from the European Lacidipine Study on AtherosclerosisGiuseppe Mancia
Clinica Medica and Department of Clinical Medicine and Prevention, University of Milano Bicocca and Ospedale S Gerardo, Monza, Milan, Italy
J Hypertens 25:1087-94. 2007..Information on the features of long-term modifications of clinic and 24-h ambulatory blood pressure (ABP) by treatment is limited. The present study aimed to address this issue...
- Presenilin1/gamma-secretase promotes the EphB2-induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding proteinAnastasios Georgakopoulos
Center for Molecular Biology and Genetics of Neurodegeneration, Department of Psychiatry, Mt Sinai School of Medicine, New York University, 1 Gustave L Levy Pl, Box 1229, New York, NY 10029, USA
FASEB J 25:3594-604. 2011..regulation of phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding protein (PAG/Cbp), an adaptor protein that controls the activity of Src kinases...
- Cooperative role of caveolin-1 and C-terminal Src kinase binding protein in C-terminal Src kinase-mediated negative regulation of c-SrcAaron T Place
Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA
Mol Pharmacol 80:665-72. 2011In the present study, we assessed the cooperative roles of C-terminal Src kinase (Csk) binding protein (Cbp) and Caveolin-1 (Cav-1) in the mechanism of Src family tyrosine kinase (SFK) inhibition by Csk...
- Expression patterns of histone acetyltransferases p300 and CBP during murine tooth developmentZhu Chen
State Key Laboratory of Oral Disease, West China College of Stomatology, Sichuan University, Chengdu, 610041, China
In Vitro Cell Dev Biol Anim 48:61-8. 2012The transcription coactivators p300 and CBP were reported to have indispensable roles in various tissues during the embryonic and fetal stages...
- The effectiveness of high-flow regional cerebral perfusion in Norwood stage I palliationKagami Miyaji
Department of Cardiovascular Surgery, Kitasato University School of Medicine, Sagamihara, Japan
Eur J Cardiothorac Surg 40:1215-20. 2011Regional cerebral perfusion (RCP) has been shown to provide cerebral circulatory support during Norwood procedure...
- Structural features responsible for the biological stability of Histoplasma's virulence factor CBPMoriah R Beck
Department of Molecular Microbiology, Washington University, St Louis, Missouri 63110, USA
Biochemistry 47:4427-38. 2008The virulence factor CBP is the most abundant protein secreted by Histoplasma capsulatum, a pathogenic fungus that causes histoplasmosis...
- Contribution of Ser386 and Ser396 to activation of interferon regulatory factor 3Weijun Chen
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
J Mol Biol 379:251-60. 2008..This phosphoactivation triggers IRF-3 to react with the coactivators, CREB-binding protein (CBP)/p300, to form a complex that activates target genes in the nucleus...
- Down-regulation of the tumor suppressor C-terminal Src kinase (Csk)-binding protein (Cbp)/PAG1 is mediated by epigenetic histone modifications via the mitogen-activated protein kinase (MAPK)/phosphatidylinositol 3-kinase (PI3K) pathwayKei Suzuki
Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
J Biol Chem 286:15698-706. 2011The transmembrane adaptor protein Cbp (or PAG1) functions as a suppressor of Src-mediated tumor progression by promoting the inactivation of Src...
- [Immune and inflammation confusion in severe sepsis and effects of bi-immunomodulation therapy: a prospective, randomized, controlled clinical trial]Li Xin Zhou
Intensive Care Unit, First Hospital of Foshan, Foshan 528000, China
Zhonghua Yi Xue Za Zhi 89:1028-33. 2009To investigate the immune and inflammation confusion state in severe sepsis and the effects of two way immunomodulation therapy with continuous blood purification (CBP), thymosin alpha1, and combined therapy of CBP and thymosin alpha(1).
- Drosophila CBP is required for dorsal-dependent twist gene expressionH Akimaru
Laboratory of Molecular Genetics, Tsukuba Life Science Center, RIKEN, Ibaraki, Japan
Nat Genet 17:211-4. 1997Although CREB-binding protein (CBP) functions as a co-activator of many transcription factors, relatively little is known about the physiological role of CBP...
- Partial depletion of CREB-binding protein reduces life expectancy in a mouse model of Huntington diseaseAlexandra M Klevytska
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Neuropathol Exp Neurol 69:396-404. 2010..reported that mutant huntingtin (htt) interferes with cyclic AMP response element binding protein binding protein (CBP)-mediated transcription, possibly by inhibiting the acetylation of histones...
- Corn expressing an Escherichia coli-derived phytase gene: residual phytase activity and microstructure of digesta in broiler chicksE K D Nyannor
Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA
Poult Sci 88:1413-20. 2009..The phytase activity of the corn expressing phytase (CBP) was determined to be 660 phytase units/g and was incorporated into broiler diets at varying rates...
- Cyclooxygenase-2 gene promoter polymorphisms affect susceptibility to hepatitis C virus infection and disease progressionMasashi Sakaki
Division of Gastroenterology, Department of Medicine Clinical Research Laboratory, Showa University School of Medicine, Tokyo, Japan
Hepatol Res 40:1219-26. 2010..However, once chronic infection is established, the -443TT genotype of the OPN promoter region and the -1195GG genotype of the COX-2 promoter are thought to promote inflammation and contribute to the progression of liver disease...
- [Properties of energy transfer in two host materials doped with Ir(ppy)3 and Rubrene]Yan Rui Li
Key Laboratory of Luminescence and Optical Information, Beijing Jiaotong University, Ministry of Education, Beijing 100044, China
Guang Pu Xue Yu Guang Pu Fen Xi 29:1-5. 2009..Respectively, the two kinds of host are polyvinylcarbazole [PVK] and 4,4'-N,N-dicarbazole-biphenyl [CBP]. We studied the properties of energy transfer between host materials and dopants...
- CREB binding protein is required for both short-term and long-term memory formationGuiquan Chen
Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 30:13066-77. 2010CREB binding protein (CBP) is a transcriptional coactivator with histone acetyltransferase activity. Our prior study suggested that CBP might be a key target of presenilins in the regulation of memory formation and neuronal survival...
- Coactivation of the CLOCK-BMAL1 complex by CBP mediates resetting of the circadian clockYool Lee
Department of Biological Sciences and 21st Frontier Program in Neuroscience, Seoul National University, Seoul 151 742, Korea
J Cell Sci 123:3547-57. 2010..Here, we demonstrate that the CREB-binding protein (CBP) plays a key role in rapid activation of the CLOCK-BMAL1 heterodimer that leads to phase resetting of the circadian ..
- Portability of the GN(R)A hairpin loop motif between RNA and DNAJoshua M Blose
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Biochemistry 48:8787-94. 2009..mimicry and electrostatic factors to attain exceptional thermodynamic stability with a CG closing base pair (cbp)...
- Low-frequency vibrational modes and infrared absorbance of red, blue and green opsinSaravana Prakash Thirumuruganandham
Fachbereich Physik und Forschungszentrum OPTIMAS, Universitat Kaiserslautern, Erwin Schrodinger Strasse, 67663, Kaiserslautern, Germany
J Mol Model 15:959-69. 2009..We thus demonstrate that terahertz spectroscopy of low-frequency modes might be relevant for identifying those vibrational degrees of freedom that correlate to known conformational changes in opsins...
- The transmembrane adaptor Cbp/PAG1 controls the malignant potential of human non-small cell lung cancers that have c-src upregulationTakashi Kanou
Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
Mol Cancer Res 9:103-14. 2011..We previously reported that a transmembrane adaptor Csk-binding protein (Cbp; PAG1) plays an important role in controlling the cell transformation that is induced by the activation of c-Src...
- Genetic polymorphisms in hMTH1, hOGG1 and hMYH and risk of chronic benzene poisoning in a Chinese occupational populationFen Wu
Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, China
Toxicol Appl Pharmacol 233:447-53. 2008..to DNA induced by benzene is an important mechanism of its genotoxicity, which leads to chronic benzene poisoning (CBP)...
- Is "usual" blood pressure a proxy for 24-h ambulatory blood pressure in predicting cardiovascular outcomes?Jerzy Gasowski
Department of Internal Medicine and Gerontology, Jagiellonian University, Krakow, Poland
Am J Hypertens 21:994-1000. 2008..ambulatory blood pressure (ABP) is a stronger predictor of cardiovascular disease than conventional blood pressure (CBP), but it remains unclear how it compares with "usual" blood pressure (UBP), estimated after CBP has been ..
- [Effects of predator stress on the expression of cAMP responsive element binding protein in hippocampus: experiment with rats]Qing Song Wang
Department of Neurology, Chengdu Army General Hospital, Chengdu 610083, China
Zhonghua Yi Xue Za Zhi 87:3367-71. 2007..To explore the neurobiological basis involved in the pathogenesis of the lasting emotionality and cognitive impairment following severe psychological stress...
- Purification and characterization of recombinant CH3 domain fragment of the CREB-binding proteinCatherine Ibarra Drendall
Department of Medicine, Duke University Medical Center, Box 2628, Durham, NC 27710, USA
Protein Expr Purif 70:196-205. 2010CREB-binding protein (CBP) is an important coactivator of basal transcription machinery and a critical regulator of cellular proliferation, differentiation, and apoptosis...
- Molecular biology of the visual pigmentsM L Applebury
Vision Res 26:1881-95. 1986..The lessons learned about visual pigments can be applied broadly to a general set of membrane receptors...
- Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit CBP-NF-kappaB interaction in activated microgliaMario Delgado
Departamento Biologia Celular, Facultad de Biologia, Universidad Complutense, 28040, Madrid, Spain
Biochem Biophys Res Commun 297:1181-5. 2002..An additional regulatory element in the NF-kappaB transcriptional activity is the coactivator CBP, which links p65 with components of the basal transcriptional machinery...
- Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domainNatalie K Goto
Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 277:43168-74. 2002The interactions between cAMP-response element-binding protein (CREB)-binding protein (CBP) and gene-specific transcription factors play an important role in activation of transcription from numerous genes...
- Isolation, characterization, and cDNA sequence of a carotenoid binding protein from the silk gland of Bombyx mori larvaeHiroko Tabunoki
Bio Application and System Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 183 0054, Japan
J Biol Chem 277:32133-40. 2002A carotenoid binding protein (CBP) has been isolated from the silk glands of Bombyx mori larvae. The protein has an apparent molecular mass of 33 kDa and binds carotenoids in a 1:1 molar ratio...
- Novel missense mutations in red/green opsin genes in congenital color-vision deficienciesHisao Ueyama
Department of Medical Biochemistry, Shiga University of Medical Science, Seta, Otsu 520 2192, Japan
Biochem Biophys Res Commun 294:205-9. 2002..Therefore these three mutant opsins are likely to be affected in the folding process, resulting in a loss of function as a visual pigment...
- Roles of CBP & PCAF During Hematopoietic DifferentiationGERD BLOBEL; Fiscal Year: 2005..One class of such enzymes consists of histone acetyltransferases which includes the widely expressed molecules CBP, its close relative p300, and the p300/CBP-associated factor PCAF...
- Structure/Function of Histone AcetyltransferasesRonen Marmorstein; Fiscal Year: 2010..Aberrant HAT function has also been correlated with human disease, including leukemic translocations involving the CBP and MOZ HATs, and p300 HAT alterations in colorectal and gastric cancers...
- Structure/Function of Histone AcetyltransferasesRonen Marmorstein; Fiscal Year: 2009..Aberrant HAT function has also been correlated with human disease, including leukemic translocations involving the CBP and MOZ HATs, and p300 HAT alterations in colorectal and gastric cancers...
- Structure/Function of Histone AcetyltransferasesRonen Marmorstein; Fiscal Year: 2011..Aberrant HAT function has also been correlated with human disease, including leukemic translocations involving the CBP and MOZ HATs, and p300 HAT alterations in colorectal and gastric cancers...
- CONTROL OF P53 TUMOR SUPPRESSOR BY CBP/P300Tso Pang Yao; Fiscal Year: 2005DESCRIPTION (from the application): The long-term objective of this proposal is to elucidate the function of CBP and its family member p300 in cellular growth and oncogenesis...
- Long-range function of the ERV-9 LTR in regulating globin gene switchingDorothy Tuan; Fiscal Year: 2009..We subsequently found that in the LTR Tg mice, LTR deletion lowered the levels of NF-Y, GATA-2 and CBP on the ?-globin promoter but increased the levels of these factors on the ?-globin promoter in adult erythroid ..
- Long-range function of the ERV-9 LTR in regulating globin gene switchingDOROTHY Y TUAN; Fiscal Year: 2010..We subsequently found that in the LTR Tg mice, LTR deletion lowered the levels of NF-Y, GATA-2 and CBP on the ?-globin promoter but increased the levels of these factors on the ?-globin promoter in adult erythroid ..
- Regulation of NFkappaB activity by the Estrogen ReceptorKendall W Nettles; Fiscal Year: 2010..This hypothesis will be pursued in the following Specific Aims: SPECIFIC AIM 1. To investigate the importance of CBP and Grip1 in the molecular interactions required for ER-mediated suppression of NF-B, we will measure their ..
- Regulation of NFkappaB activity by the Estrogen ReceptorKendall W Nettles; Fiscal Year: 2010..This hypothesis will be pursued in the following Specific Aims: SPECIFIC AIM 1. To investigate the importance of CBP and Grip1 in the molecular interactions required for ER-mediated suppression of NF-B, we will measure their ..
- REGULATION OF GROWTH FACTORS AND EMBRYOGENESISARNOLD RIZZINO; Fiscal Year: 2005..its effects? Recent studies argue that Sox-2 and Oct-3 can mediate their effects through the co-activators p300 and CBP (p300/CBP)...
- Regulation of HTLV-1 and cellular gene transcription by the viral protein HBZISABELLE MICHELE LEMASSON; Fiscal Year: 2010..We found that HBZ also binds directly to the cellular coactivators p300 and CBP, which is mediated through regions of the viral protein outside its bZIP domain...
- TRANSCRIPTION FACTOR INTERACTIONS AT THE GH PROMOTERFred Schaufele; Fiscal Year: 2001..factor C/EBPalpha cooperates with the pituitary-specific transcription factor Pit-1 and the coactivator CBP to control protein kinase A and C-regulated GH gene transcription...
- Mechanisms of p53 activation in tumorsuppressionWei Gu; Fiscal Year: 2010..In our early studies, we found that histone acetyltransferase CBP/p300 promotes p53-dependent transcription by directly acetylating lysine residues in the C-terminal region of p53...
- C/EBP, atrogin-1, and muscle wastingPer Olof Hasselgren; Fiscal Year: 2007..In particular, the role of the transcription factor C/EBP and nuclear co-factors p300/CBP for regulation of genes in the ubiquitin-proteasome pathway has not been defined...
- Characterization of Neuroendocrine CGRP ReceptorsIan Dickerson; Fiscal Year: 2006We have discovered a 148 aa protein named calcitonin gene-related peptide (CGRP)-receptor component protein (RCP) that is required for G protein-coupled signal transduction at receptors for the neuropeptide CGRP...
- Chemical Modulators for p53 Functions in Transcriptional RegulationSYED S MUJTABA; Fiscal Year: 2011..Our study revealed that p53 recruitment of the co-activator CBP (CREB binding protein) requires association of the conserved bromodomain of CBP (CBP BRD) with p53 at acetylated ..
- Chemical Modulators for p53 Functions in Transcriptional RegulationSYED S MUJTABA; Fiscal Year: 2010..Our study revealed that p53 recruitment of the co-activator CBP (CREB binding protein) requires association of the conserved bromodomain of CBP (CBP BRD) with p53 at acetylated ..
- SRCAP Regulation of CREB and GR-mediated TranscriptionJohn Chrivia; Fiscal Year: 2005CREB-binding protein (CBP) functions as a coactivator for many transcription factors and is able to respond to extracellular signals to specifically regulate gene expression...
- Molecular Functions of the Adenovirus E1A OncogeneMaurice Green; Fiscal Year: 2006..A large panel of EIA single amino acid substitution mutants will be used to define interactions among E1A, p300/CBP, and TBP and to establish their relevance to the E1A repression function...
- STRUCTURE AND FUNCTION OF SV40 NON-VIRION PROTEINSDavid Livingston; Fiscal Year: 2007Abstract: The specific aims of the ongoing work are : 1) to understand how p300 and CBP participate in the operations of hematopoietic stem cells and, as such, to learn how they operate as hematopoeitic tumor suppressing elements; 2) to ..