opioid growth factor receptor

Summary

Gene Symbol: opioid growth factor receptor
Description: opioid growth factor receptor
Alias: opioid growth factor receptor, protein 7-60, zeta-type opioid receptor
Species: human

Top Publications

  1. Zagon I, Kreiner S, Heslop J, Conway A, Morgan C, McLaughlin P. Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptor. Int J Oncol. 2008;33:317-23 pubmed
    This study examined overexpression of the opioid growth factor receptor (OGFr) in pancreatic cancer cells and phenotypic changes in tumorigenicity. Tumors of MIA PaCa-2 cells transfected with OGFr cDNA (OGFr-1) had 3...
  2. McLaughlin P, Verderame M, Hankins J, Zagon I. Overexpression of the opioid growth factor receptor downregulates cell proliferation of human squamous carcinoma cells of the head and neck. Int J Mol Med. 2007;19:421-8 pubmed
    ..These data indicate that the OGF receptor is integral to cell replication of SCCHN, and support treatment modalities that amplify OGFr in order to decrease the growth of these neoplasias. ..
  3. Marimuthu A, Chavan S, Sathe G, Sahasrabuddhe N, Srikanth S, Renuse S, et al. Identification of head and neck squamous cell carcinoma biomarker candidates through proteomic analysis of cancer cell secretome. Biochim Biophys Acta. 2013;1834:2308-16 pubmed publisher
    ..known markers for HNSCC including insulin like growth factor binding protein 3, IGFBP3 (11-fold) and opioid growth factor receptor, OGFR (10-fold) demonstrating the validity of our approach...
  4. Tanaka K, Kondo H, Hamamura K, Togari A. Systemic administration of low-dose naltrexone increases bone mass due to blockade of opioid growth factor receptor signaling in mice osteoblasts. Life Sci. 2019;: pubmed publisher
    ..We examined the effects of naltrexone on osteoblasts and determined the expression of opioid growth factor receptor (OGFR) in osteoblasts. Naltrexone blocks the OGFR and other canonical opioid receptors...
  5. McLaughlin P, Stucki J, Zagon I. Modulation of the opioid growth factor ([Met(5)]-enkephalin)-opioid growth factor receptor axis: novel therapies for squamous cell carcinoma of the head and neck. Head Neck. 2012;34:513-9 pubmed publisher
    ..Modulation of the native OGF-OGFr regulatory network in SCCHN represents a novel nontoxic and highly efficacious approach for treatment of SCCHN. ..
  6. Wang X, Tian J, Jiao X, Geng J, Wang R, Liu N, et al. The novel mechanism of anticancer effect on gastric cancer through inducing G0/G1 cell cycle arrest and caspase-dependent apoptosis in vitro and in vivo by methionine enkephalin. Cancer Manag Res. 2018;10:4773-4787 pubmed publisher
    ..The interaction between MENK and OGFr in SGC7901 and HGC27 cells appears to be essential for the antitumor activity of MENK. We conclude that MENK may be a potential drug for the treatment of GC. ..
  7. Ludwig M, Zagon I, McLaughlin P. Featured Article: Modulation of the OGF-OGFr pathway alters cytokine profiles in experimental autoimmune encephalomyelitis and multiple sclerosis. Exp Biol Med (Maywood). 2018;243:361-369 pubmed publisher
    ..These data, along with serum levels of OGF, begin to formulate a selective biomarker profile for MS that is easily measured and effective at monitoring disease progression and response to therapy. ..
  8. Wang X, Jiao X, Meng Y, Chen H, Griffin N, Gao X, et al. Methionine enkephalin (MENK) inhibits human gastric cancer through regulating tumor associated macrophages (TAMs) and PI3K/AKT/mTOR signaling pathway inside cancer cells. Int Immunopharmacol. 2018;65:312-322 pubmed publisher
    ..Therefore, it is concluded that MENK might skew macrophage toward M2 phenotype from M1 phenotype within tumor and induce cells apoptosis though blocking OGFr/PI3K/AKT/mTOR signaling pathway. ..
  9. McLaughlin P, McHugh D, Magister M, Zagon I. Endogenous opioid inhibition of proliferation of T and B cell subpopulations in response to immunization for experimental autoimmune encephalomyelitis. BMC Immunol. 2015;16:24 pubmed publisher
    ..The opioid growth factor-opioid growth factor receptor (OGF-OGFr) axis has been shown to effectively limit progression of chronic EAE when mice are treated ..

More Information

Publications32

  1. Hiramoto K, Yamate Y, Sugiyama D, Matsuda K, Iizuka Y, Yamaguchi T. Tranexamic acid inhibits the plasma and non-irradiated skin markers of photoaging induced by long-term UVA eye irradiation in female mice. Biomed Pharmacother. 2018;107:54-58 pubmed publisher
    ..as the expression of the corticotropin-releasing hormone receptor (CRHR) type 2, μ-opioid receptor, opioid growth factor receptor (OGFR), T-bet, and GATA3 increased in the mice subjected to UVA eye irradiation...
  2. Hammer L, Waldner H, Zagon I, McLaughlin P. Opioid growth factor and low-dose naltrexone impair central nervous system infiltration by CD4 + T lymphocytes in established experimental autoimmune encephalomyelitis, a model of multiple sclerosis. Exp Biol Med (Maywood). 2016;241:71-8 pubmed publisher
    ..However, modulation of the OGF-OGFr axis did not result in changes to CD4(+) Th effector cell responses in the CNS of EAE mice. ..
  3. McLaughlin P, Zagon I. Duration of opioid receptor blockade determines biotherapeutic response. Biochem Pharmacol. 2015;97:236-46 pubmed publisher
  4. Kren N, Zagon I, McLaughlin P. Featured Article: Nuclear export of opioid growth factor receptor is CRM1 dependent. Exp Biol Med (Maywood). 2016;241:273-81 pubmed publisher
    b>Opioid growth factor receptor (OGFr) facilitates growth inhibition in the presence of its specific ligand opioid growth factor (OGF), chemically termed [Met(5)]-enkephalin...
  5. Kim J, Ahn H, Kim J, Kim J, Lee S, Chae H. Morphine Suppresses Lung Cancer Cell Proliferation Through the Interaction with Opioid Growth Factor Receptor: An In Vitro and Human Lung Tissue Study. Anesth Analg. 2016;123:1429-1436 pubmed
    ..In this study, we suggest that opioid growth factor receptor (OGFR), a negative regulator of cell proliferation, is a binding site of morphine and is involved in ..
  6. Donahue R, McLaughlin P, Zagon I. Under-expression of the opioid growth factor receptor promotes progression of human ovarian cancer. Exp Biol Med (Maywood). 2012;237:167-77 pubmed publisher
  7. Zagon I, Verderame M, Allen S, McLaughlin P. Cloning, sequencing, chromosomal location, and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humans. Brain Res. 2000;856:75-83 pubmed
    ..3. This OGF receptor has no homology to classical opioid receptors. These results provide molecular validity for the interaction of OGF and OGF receptor in the regulation of growth processes in humans. ..
  8. Stockdale D, Titunick M, Biegler J, Reed J, Hartung A, Wiemer D, et al. Selective opioid growth factor receptor antagonists based on a stilbene isostere. Bioorg Med Chem. 2017;25:4464-4474 pubmed publisher
    ..Three of the isomers synthesized showed antagonist activity for the opioid growth factor (OGF)/opioid growth factor receptor (OGFR) axis which is involved in cellular and organ growth control...
  9. Suzuki M, Chiwaki F, Sawada Y, Ashikawa M, Aoyagi K, Fujita T, et al. Peripheral opioid antagonist enhances the effect of anti-tumor drug by blocking a cell growth-suppressive pathway in vivo. PLoS ONE. 2015;10:e0123407 pubmed publisher
    ..These results suggest that blockade of the pathways that suppress cell growth may enhance the effects of anti-tumor drugs. ..
  10. McLaughlin P, Zagon I, Park S, Conway A, Donahue R, Goldenberg D. Growth inhibition of thyroid follicular cell-derived cancers by the opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis. BMC Cancer. 2009;9:369 pubmed publisher
    ..These results may provide a biotherapeutic strategy in the treatment of these cancers. ..
  11. Zagon I, Donahue R, McLaughlin P. Opioid growth factor-opioid growth factor receptor axis is a physiological determinant of cell proliferation in diverse human cancers. Am J Physiol Regul Integr Comp Physiol. 2009;297:R1154-61 pubmed publisher
    ..The identification of this native biological system in neoplasia may be important in understanding the pathophysiology of neoplasia, and in designing treatment modalities that utilize the body's own chemistry. ..
  12. Donahue R, McLaughlin P, Zagon I. Cell proliferation of human ovarian cancer is regulated by the opioid growth factor-opioid growth factor receptor axis. Am J Physiol Regul Integr Comp Physiol. 2009;296:R1716-25 pubmed publisher
    ..These data are the first to report that the OGF-OGFr system is a native biological regulator of cell proliferation in human ovarian cancer. This information will be important in designing treatment strategies for this deadly disease. ..
  13. Cheng F, McLaughlin P, Verderame M, Zagon I. The OGF-OGFr axis utilizes the p16INK4a and p21WAF1/CIP1 pathways to restrict normal cell proliferation. Mol Biol Cell. 2009;20:319-27 pubmed publisher
    ..Collectively, these results indicate that both p16(INK4a) and p21(WAF1/CIP1) are required for the OGF-OGFr axis to inhibit cell proliferation in normal cells. ..
  14. Wu Y, Xiong Q, Li S, Yang X, Ge F. Integrated Proteomic and Transcriptomic Analysis Reveals Long Noncoding RNA HOX Transcript Antisense Intergenic RNA (HOTAIR) Promotes Hepatocellular Carcinoma Cell Proliferation by Regulating Opioid Growth Factor Receptor (OGFr). Mol Cell Proteomics. 2018;17:146-159 pubmed publisher
    ..Further functional studies of the opioid growth factor receptor (OGFr), a negative biological regulator of cell proliferation in HCC, revealed that HOTAIR exerts its ..
  15. Wu C, Yang X, McLaughlin S, Neuberg D, Canning C, Stein B, et al. Detection of a potent humoral response associated with immune-induced remission of chronic myelogenous leukemia. J Clin Invest. 2000;106:705-14 pubmed
    ..The characterization of B cell-defined antigens may help identify clinically relevant targets of the GVL response in vivo. ..
  16. Thakur N, DeBoyace S, Margulies B. Antagonism of the Met5-enkephalin-opioid growth factor receptor-signaling axis promotes MSC to differentiate into osteoblasts. J Orthop Res. 2016;34:1195-205 pubmed publisher
    ..The opioid growth factor receptor (OGFR) is a non-canonical opioid receptor that binds naloxone with high affinity whereas the native ..
  17. Avella D, Kimchi E, Donahue R, Tagaram H, McLaughlin P, Zagon I, et al. The opioid growth factor-opioid growth factor receptor axis regulates cell proliferation of human hepatocellular cancer. Am J Physiol Regul Integr Comp Physiol. 2010;298:R459-66 pubmed publisher
    ..These data are the first to report that the OGF-OGFr system is a native biological regulator of cell proliferation in HCC. The findings may provide important insight in designing treatment strategies for this deadly disease. ..
  18. Cheng F, McLaughlin P, Verderame M, Zagon I. Dependence on nuclear localization signals of the opioid growth factor receptor in the regulation of cell proliferation. Exp Biol Med (Maywood). 2009;234:532-41 pubmed publisher
    The opioid growth factor receptor (OGFr) mediates the inhibitory action of OGF on cell replication of normal and neoplastic cells...
  19. Zagon I, Ruth T, Leure Dupree A, Sassani J, McLaughlin P. Immunoelectron microscopic localization of the opioid growth factor receptor (OGFr) and OGF in the cornea. Brain Res. 2003;967:37-47 pubmed
    This study was conducted to determine the cellular and subcellular location(s) of the opioid growth factor receptor (OGFr), and the opioid growth factor (OGF), [Met(5)]-enkephalin, in the corneal epithelium...
  20. McLaughlin P, Zagon I. Progression of squamous cell carcinoma of the head and neck is associated with down-regulation of the opioid growth factor receptor. Int J Oncol. 2006;28:1577-83 pubmed
    ..Gene therapy to reinstate more OGFr, and thus enhance OGFr function, could serve as a useful treatment for inhibiting tumor progression. ..
  21. Zagon I, Donahue R, McLaughlin P. Targeting the opioid growth factor: opioid growth factor receptor axis for treatment of human ovarian cancer. Exp Biol Med (Maywood). 2013;238:579-87 pubmed publisher
    The opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis is a biological pathway that is present in human ovarian cancer cells and tissues...
  22. Zagon I, Verderame M, McLaughlin P. The biology of the opioid growth factor receptor (OGFr). Brain Res Brain Res Rev. 2002;38:351-76 pubmed
    ..This report reviews the history of OGF-OGFr, examines emerging insights into the mechanisms of action of opioid peptide-receptor interfacing, and discusses the clinical significance of these observations. ..
  23. Zagon I, McLaughlin P. Opioid growth factor receptor is unaltered with the progression of human pancreatic and colon cancers. Int J Oncol. 2006;29:489-94 pubmed
    ..This information will be relevant in the design of therapeutic modalities, the diagnosis and prognosis of neoplasia, as well as understanding of the processes and mechanisms of carcinogenesis. ..