oncostatin M

Summary

Gene Symbol: oncostatin M
Description: oncostatin M
Alias: oncostatin-M
Species: human
Products:     oncostatin M

Top Publications

  1. Rega G, Kaun C, Weiss T, Demyanets S, Zorn G, Kastl S, et al. Inflammatory cytokines interleukin-6 and oncostatin m induce plasminogen activator inhibitor-1 in human adipose tissue. Circulation. 2005;111:1938-45 pubmed
    ..Another gp130 ligand, oncostatin M (OSM), upregulates PAI-1 in cardiac myocytes, astrocytes, and endothelial cells...
  2. Mosley B, De Imus C, Friend D, Boiani N, Thoma B, Park L, et al. Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. J Biol Chem. 1996;271:32635-43 pubmed
    b>Oncostatin M (OSM) is a cytokine whose structural and functional features are similar to other members of the interleukin (IL)-6 family of cytokines (IL-6, IL-11, leukemia inhibitory factor (LIF), granulocyte colonystimulating factor, ..
  3. Jorcyk C, Holzer R, Ryan R. Oncostatin M induces cell detachment and enhances the metastatic capacity of T-47D human breast carcinoma cells. Cytokine. 2006;33:323-36 pubmed
    b>Oncostatin M (OSM), an IL-6 family cytokine, has previously been shown to increase migration of several breast cancer cell lines in vitro...
  4. Boniface K, Diveu C, Morel F, Pedretti N, Froger J, Ravon E, et al. Oncostatin M secreted by skin infiltrating T lymphocytes is a potent keratinocyte activator involved in skin inflammation. J Immunol. 2007;178:4615-22 pubmed
  5. Miles S, Martinez Maza O, Rezai A, Magpantay L, Kishimoto T, Nakamura S, et al. Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells. Science. 1992;255:1432-4 pubmed
    b>Oncostatin M, a cytokine produced by activated lymphoid cells, regulates the growth and differentiation of a number of tumor and normal cells...
  6. Fearon U, Mullan R, Markham T, Connolly M, Sullivan S, Poole A, et al. Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures. Arthritis Rheum. 2006;54:3152-62 pubmed
    To investigate the role of oncostatin M (OSM) in cell adhesion, angiogenesis, and matrix degradation in rheumatoid arthritis (RA) synovial tissue and normal human cartilage...
  7. Hohensinner P, Kaun C, Rychli K, Niessner A, Pfaffenberger S, Rega G, et al. The inflammatory mediator oncostatin M induces stromal derived factor-1 in human adult cardiac cells. FASEB J. 2009;23:774-82 pubmed publisher
    ..HACMs and HACFs constitutively express SDF-1, which was significantly up-regulated by the gp130 ligand oncostatin M (OSM). This effect was counteracted by a p38 inhibitor and to a lesser extent by a PI3K inhibitor...
  8. Duong H, Yin Y, Thambi T, Nguyen T, Giang Phan V, Lee M, et al. Smart vaccine delivery based on microneedle arrays decorated with ultra-pH-responsive copolymers for cancer immunotherapy. Biomaterials. 2018;185:13-24 pubmed publisher
    ..The maneuvered use of vaccine and adjuvant poly(I:C) in MNs induces humoral and cellular immunity, which provides a promising vaccine technology that shows improved efficacy, compliance, and safety. ..
  9. Xiao J, Liong E, Huang H, On Tse W, Lau K, Pan J, et al. Cyclooxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury. Toxicol Sci. 2015;143:430-40 pubmed publisher
    ..In conclusion, basal expression of COX-1 is essential for the protection of liver against chemical-induced hepatotoxicity and required for hepatic homeostatic maintenance. ..

More Information

Publications130 found, 100 shown here

  1. Han J, Puri R. Analysis of the cancer genome atlas (TCGA) database identifies an inverse relationship between interleukin-13 receptor α1 and α2 gene expression and poor prognosis and drug resistance in subjects with glioblastoma multiforme. J Neurooncol. 2018;136:463-474 pubmed publisher
    ..These findings have important implications in understanding the role of IL-13R in the pathogenesis of GBM and potentially other cancers. ..
  2. Charron C, Dawson H, Albaugh G, Solverson P, Vinyard B, Solano Aguilar G, et al. A Single Meal Containing Raw, Crushed Garlic Influences Expression of Immunity- and Cancer-Related Genes in Whole Blood of Humans. J Nutr. 2015;145:2448-55 pubmed publisher
    ..of activated T cells (NFAT) activating protein with immunoreceptor tyrosine-based activation motif 1 (NFAM1), oncostatin M (OSM), and V-rel avian reticuloendotheliosis viral oncogene homolog (REL)...
  3. Eddie S, Childs A, Jabbour H, Anderson R. Developmentally regulated IL6-type cytokines signal to germ cells in the human fetal ovary. Mol Hum Reprod. 2012;18:88-95 pubmed publisher
    ..Data suggest the interleukin (IL)6-type cytokines, leukaemia inhibitory factor (LIF), IL6, oncostatin M (OSM) and ciliary neurotrophic factor (CNTF), are able to regulate the survival, proliferation and ..
  4. Strålberg F, Kassem A, Kasprzykowski F, Abrahamson M, Grubb A, Lindholm C, et al. Inhibition of lipopolysaccharide-induced osteoclast formation and bone resorption in vitro and in vivo by cysteine proteinase inhibitors. J Leukoc Biol. 2017;101:1233-1243 pubmed publisher
    ..2 (gene encoding TNF-?; Tnfsf2) mRNA expression without affecting Il1b, Il6, or oncostatin M (Osm) expression...
  5. Sun Y, Kuek V, Qiu H, Tickner J, Chen L, Wang H, et al. The emerging role of NPNT in tissue injury repair and bone homeostasis. J Cell Physiol. 2018;233:1887-1894 pubmed publisher
    ..range of external factors such as tumor necrosis factor alpha (TNF-?), transforming growth factor beta (TGF-?), oncostatin M (OSM), bone morphogenic protein 2 (BMP2), Wnt3a, Vitamin D3 , and microRNA-378 (miR378)...
  6. Dunnington L, Nakagawa M. Fast and safe gas detection from underground coal fire by drone fly over. Environ Pollut. 2017;229:139-145 pubmed publisher
    ..In this study, a new method of determining coal rank by gas ratios is developed. Coal rank is valuable for defining parameters of a coal seam such as burn temperature, burn rate, and volume of burning seam. ..
  7. Sims N. Cell-specific paracrine actions of IL-6 family cytokines from bone, marrow and muscle that control bone formation and resorption. Int J Biochem Cell Biol. 2016;79:14-23 pubmed publisher
    ..osteoclast formation by osteoblast lineage cells in response to interleukin 6 (IL-6), interleukin 11 (IL-11), oncostatin M (OSM) and cardiotrophin 1 (CT-1)...
  8. Couderc E, Morel F, Levillain P, Buffiere Morgado A, Camus M, Paquier C, et al. Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis. PLoS ONE. 2017;12:e0181486 pubmed publisher
    ..Keratinocytes could contribute to psoriasis pathogenesis via A-SAA production, maintaining a cutaneous inflammatory environment, activating innate immunity and Th17 lymphocyte recruitment. ..
  9. Ni K, Umair Mukhtar Mian M, Meador C, Gill A, Barwinska D, Cao D, et al. Oncostatin M and TNF-α Induce Alpha-1 Antitrypsin Production in Undifferentiated Adipose Stromal Cells. Stem Cells Dev. 2017;26:1468-1476 pubmed publisher
    ..from nonsmoking or smoking donors were stimulated by inflammatory cytokines tumor necrosis alpha (TNFα), oncostatin M (OSM), and/or dexamethasone (DEX) or were exposed to sublethal concentrations of ambient air control or CS ..
  10. Snelling S, Davidson R, Swingler T, Le L, Barter M, Culley K, et al. Dickkopf-3 is upregulated in osteoarthritis and has a chondroprotective role. Osteoarthritis Cartilage. 2016;24:883-91 pubmed publisher
    ..Targeting Dkk3 may be a novel approach in the treatment of OA. ..
  11. Esnault S, Bernau K, Torr E, Bochkov Y, Jarjour N, Sandbo N. RNA-sequencing analysis of lung primary fibroblast response to eosinophil-degranulation products predicts downstream effects on inflammation, tissue remodeling and lipid metabolism. Respir Res. 2017;18:188 pubmed publisher
    ..These findings may have significant implications on the role of eosinophil/fibroblast interactions in eosinophilic disorders. ..
  12. Taranu I, Marin D, Braicu C, Pistol G, Sorescu I, Pruteanu L, et al. In Vitro Transcriptome Response to a Mixture of Lactobacilli Strains in Intestinal Porcine Epithelial Cell Line. Int J Mol Sci. 2018;19: pubmed publisher
    ..peptidase inhibitor, clade A member 3 (SERPINA 3), interleukin-20 (IL-20), oncostatin M(OSM), granulocyte-macrophage colony-stimulating factor (GM-CSF), and the suppression ..
  13. Meares G, Liu Y, Rajbhandari R, Qin H, Nozell S, Mobley J, et al. PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation. Mol Cell Biol. 2014;34:3911-25 pubmed publisher
    ..astrocytes, via paracrine signaling, can stimulate activation of microglia, leading to production of IL-6 and oncostatin M (OSM). These IL-6 cytokines can then synergize with ER stress in astrocytes to drive inflammation...
  14. O HAGAN R, Barr M. Kymographic Analysis of Transport in an Individual Neuronal Sensory Cilium in Caenorhabditis elegans. Methods Mol Biol. 2016;1454:107-22 pubmed publisher
    ..1) with settings that have worked well for us measuring movement of heterotrimeric kinesin-II, IFT particles, and the polycystin TRP channel PKD-2. ..
  15. Baker J, Falconer A, Wilkinson D, Europe Finner G, Litherland G, Rowan A. Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes. PLoS ONE. 2018;13:e0195864 pubmed publisher
    Many catabolic stimuli, including interleukin-1 (IL-1) in combination with oncostatin M (OSM), promote cartilage breakdown via the induction of collagen-degrading collagenases such as matrix metalloproteinase 1 (MMP1) and MMP13 in human ..
  16. Stachenfeld N, Silva C, Keefe D, Kokoszka C, Nadel E. Effects of oral contraceptives on body fluid regulation. J Appl Physiol (1985). 1999;87:1016-25 pubmed
  17. Pereira de Sousa F, Chaiwangyen W, Morales Prieto D, Ospina Prieto S, Weber M, Photini S, et al. Involvement of STAT1 in proliferation and invasiveness of trophoblastic cells. Reprod Biol. 2017;17:218-224 pubmed publisher
    ..Here, potential functions of STAT1 and its activation by Oncostatin M (OSM) have been investigated in an in vitro model...
  18. Wei J, Ma L, Lai Y, Zhang R, Li H, Li C, et al. Bazedoxifene as a novel GP130 inhibitor for Colon Cancer therapy. J Exp Clin Cancer Res. 2019;38:63 pubmed publisher
    ..Taken together, these results support bazedoxifene as a novel and effective therapeutic agent targeting IL-11/GP130 signaling for human colorectal cancer therapy. ..
  19. Park K, Lin C, Benveniste E, Lee Y. Mitochondrial STAT3 is negatively regulated by SOCS3 and upregulated after spinal cord injury. Exp Neurol. 2016;284:98-105 pubmed publisher
    ..Immunoblot analyses demonstrated that Oncostatin M (OSM), a member of the interleukin-6 (IL-6) cytokine family, induced both P-STAT3 Tyr and P-STAT3 Ser in SH-..
  20. Turabee M, Thambi T, Duong H, Jeong J, Lee D. A pH- and temperature-responsive bioresorbable injectable hydrogel based on polypeptide block copolymers for the sustained delivery of proteins in vivo. Biomater Sci. 2018;6:661-671 pubmed publisher
    ..Overall, the results demonstrate an elegant approach to control the release of certain charged proteins and open a myriad of therapeutic possibilities in protein therapeutics. ..
  21. Rolvering C, Zimmer A, Kozar I, Hermanns H, Letellier E, Vallar L, et al. Crosstalk between different family members: IL27 recapitulates IFN? responses in HCC cells, but is inhibited by IL6-type cytokines. Biochim Biophys Acta Mol Cell Res. 2017;1864:516-526 pubmed publisher
    ..Thus, IL27 recapitulates IFN? responses in liver cells, but differs from IFN? by its sensitivity to SOCS3 inhibition. ..
  22. Hicks M, Hu Q, MacRae E, DeWille J. Mitogen-activated protein kinase signaling controls basal and oncostatin M-mediated JUNB gene expression. Mol Cell Biochem. 2015;403:115-24 pubmed publisher
    ..b>Oncostatin M (OSM) enhances MAPK and STAT3 signaling and significantly induces JUNB expression...
  23. Molanouri Shamsi M, Chekachak S, Soudi S, Gharakhanlou R, Quinn L, Ranjbar K, et al. Effects of exercise training and supplementation with selenium nanoparticle on T-helper 1 and 2 and cytokine levels in tumor tissue of mice bearing the 4 T1 mammary carcinoma. Nutrition. 2019;57:141-147 pubmed publisher
    ..These findings suggest that the combination of AET and SeNP supplementation effects antitumor immune responses in splenocytes, whereas AET induced antitumor cytokines, such as OSM and TNF-α in tumor tissue. ..
  24. Zhang Z, Song C, Zhang F, Xiang L, Chen Y, Li Y, et al. Rhizoma Dioscoreae extract protects against alveolar bone loss in ovariectomized rats via microRNAs regulation. Nutrients. 2015;7:1333-51 pubmed publisher
    ..proteins (BMPs)/Smad signaling pathway (Tgfbr2/Bmpr2, Smad3/4/5, and Bcl-2) and interleukin (IL)-6/oncostatin M (OSM)/Jak1/STAT3 signaling pathway (Jak1, STAT3, and Il6r)...
  25. Schwerd T, Twigg S, Aschenbrenner D, Manrique S, Miller K, Taylor I, et al. A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis. J Exp Med. 2017;214:2547-2562 pubmed publisher
    Multiple cytokines, including interleukin 6 (IL-6), IL-11, IL-27, oncostatin M (OSM), and leukemia inhibitory factor (LIF), signal via the common GP130 cytokine receptor subunit...
  26. Kim J, Kim Y, Choi J, Jung H, Lee K, Kang J, et al. Recapitulation of methotrexate hepatotoxicity with induced pluripotent stem cell-derived hepatocytes from patients with rheumatoid arthritis. Stem Cell Res Ther. 2018;9:357 pubmed publisher
    ..A patient-derived iPSC platform could recapitulate MTX toxicity. Simulation of drug toxicity in vitro may help clinicians choose safer drugs or less toxic doses. ..
  27. Jiang L, Tam B, Ying G, Wu S, Hauswirth W, Frederick J, et al. Kinesin family 17 (osmotic avoidance abnormal-3) is dispensable for photoreceptor morphology and function. FASEB J. 2015;29:4866-80 pubmed publisher
    ..In summary, the nematode model of KIF3/KIF17 cooperation apparently does not apply to mouse photoreceptors in which the photosensory cilium is built exclusively by KIF3. ..
  28. Kjelgaard Petersen C, Sharma N, Kayed A, Karsdal M, Mobasheri A, Hägglund P, et al. Tofacitinib and TPCA-1 exert chondroprotective effects on extracellular matrix turnover in bovine articular cartilage ex vivo. Biochem Pharmacol. 2018;: pubmed publisher
    ..Bovine cartilage explants were cultured with oncostatin M (OSM) and tumour necrosis factor ? (TNF-?) either alone or combined with the small molecule inhibitors: ..
  29. Zhuo C, Liang L, Zhao Y, Guo Z, Lu S. A cold responsive ERF from Medicago falcata confers cold tolerance by up-regulation of polyamine turnover, antioxidant protection and proline accumulation. Plant Cell Environ. 2017;: pubmed publisher
    ..The results suggest that MfERF1 confers cold tolerance through promoted polyamine turnover, antioxidant protection, and proline accumulation...
  30. Duong H, Kim N, Thambi T, Giang Phan V, Lee M, Yin Y, et al. Microneedle arrays coated with charge reversal pH-sensitive copolymers improve antigen presenting cells-homing DNA vaccine delivery and immune responses. J Control Release. 2018;269:225-234 pubmed publisher
    ..These findings provide potential strategy of charge reversal pH-responsive copolymers coated microneedles for DNA vaccine delivery. ..
  31. Upadhyay A, Sharma G, Kivivuori S, Raye W, Zabihi E, Carroll G, et al. Role of a LIF antagonist in LIF and OSM induced MMP-1, MMP-3, and TIMP-1 expression by primary articular chondrocytes. Cytokine. 2009;46:332-8 pubmed publisher
    ..These include leukaemia inhibitory factor (LIF) and Oncostatin M (OSM), both of which have been detected in the synovial fluids of patients with rheumatoid arthritis (RA)...
  32. Yi P, Xie C, Ou G. The kinases male germ cell-associated kinase and cell cycle-related kinase regulate kinesin-2 motility in Caenorhabditis elegans neuronal cilia. Traffic. 2018;19:522-535 pubmed publisher
    ..Our data suggest that DYF-5 and DYF-18 act in the same pathway to promote handover between kinesin-II and OSM-3 in sensory cilia. ..
  33. Zhu M, Che Q, Liao Y, Wang H, Wang J, Chen Z, et al. Oncostatin M activates STAT3 to promote endometrial cancer invasion and angiogenesis. Oncol Rep. 2015;34:129-38 pubmed publisher
    b>Oncostatin M (OSM), a pleiotropic cytokine, can either promote or inhibit the growth of tumors derived from specific tissues. However, little is known about the activity and expression pattern of OSM in endometrial cancers (ECs)...
  34. Schäfer M, Pander T, Pinilla S, Fischer M, von der Borch P, Dimitriadis K. The Munich-Evaluation-of-Mentoring-Questionnaire (MEMeQ)--a novel instrument for evaluating protégés' satisfaction with mentoring relationships in medical education. BMC Med Educ. 2015;15:201 pubmed publisher
    ..Further research is needed to evaluate the generalizability of MEMeQ across other institutions and mentoring programs to add to its validity. ..
  35. Walker E, Johnson R, Hu Y, Brennan H, Poulton I, Zhang J, et al. Murine Oncostatin M Acts via Leukemia Inhibitory Factor Receptor to Phosphorylate Signal Transducer and Activator of Transcription 3 (STAT3) but Not STAT1, an Effect That Protects Bone Mass. J Biol Chem. 2016;291:21703-21716 pubmed
    b>Oncostatin M (OSM) and leukemia inhibitory factor (LIF) are IL-6 family members with a wide range of biological functions...
  36. Noe B, Poole A, Mort J, Richard H, Beauchamp G, Laverty S. C2K77 ELISA detects cleavage of type II collagen by cathepsin K in equine articular cartilage. Osteoarthritis Cartilage. 2017;25:2119-2126 pubmed publisher
    ..cartilage explants with or without stimulation by interleukin-1 beta (IL-1?), tumour necrosis-alpha (TNF-?), oncostatin M (OSM) and lipopolysaccharide (LPS)...
  37. Elbjeirami W, Donnachie E, Burns A, Smith C. Endothelium-derived GM-CSF influences expression of oncostatin M. Am J Physiol Cell Physiol. 2011;301:C947-53 pubmed publisher
    ..two locally derived cytokines, granulocyte (G)-macrophage (M) colony-stimulating factor (GM-CSF) and G-CSF, on oncostatin M (OSM) expression...
  38. Weiss T, Simak R, Kaun C, Rega G, Pfluger H, Maurer G, et al. Oncostatin M and IL-6 induce u-PA and VEGF in prostate cancer cells and correlate in vivo. Anticancer Res. 2011;31:3273-8 pubmed
    b>Oncostatin M (OSM) and interleukin-6 (IL-6) are growth factors for prostate cancer (PC). Vascular endothelial growth factor (VEGF) and urokinase-type plasminogen-activator (u-PA) have been implicated in tumour progression...
  39. Hu J, Zhang L, Zhao Z, Zhang M, Lin J, Wang J, et al. OSM mitigates post-infarction cardiac remodeling and dysfunction by up-regulating autophagy through Mst1 suppression. Biochim Biophys Acta Mol Basis Dis. 2017;1863:1951-1961 pubmed publisher
    ..Here we examined the effects of oncostatin M (OSM) on postinfarction cardiac remodeling and the underlying mechanisms involved...
  40. Liu H, Fenollar Ferrer C, Cao A, Anselmi C, Carloni P, Liu J. Molecular dissection of human oncostatin M-mediated signal transductions through site-directed mutagenesis. Int J Mol Med. 2009;23:161-72 pubmed
    The binding of oncostatin M (OM) to type I and type II receptor complexes elicits various biological responses by activating MEK/ERK and JAK/STAT signaling pathways...
  41. Kanda J, Uchiyama T, Tomosugi N, Higuchi M, Uchiyama T, Kawabata H. Oncostatin M and leukemia inhibitory factor increase hepcidin expression in hepatoma cell lines. Int J Hematol. 2009;90:545-552 pubmed publisher
    ..Since oncostatin M (OSM), a member of the IL-6 family, plays an important role in immune and inflammatory responses, we assessed ..
  42. Kan C, Cipriano R, Jackson M. c-MYC functions as a molecular switch to alter the response of human mammary epithelial cells to oncostatin M. Cancer Res. 2011;71:6930-9 pubmed publisher
    ..b>Oncostatin M (OSM), an IL-6 family cytokine responsible for STAT3 activation, has been implicated in cancer development, ..
  43. Pal S, Lant B, Yu B, Tian R, Tong J, Krieger J, et al. CCM-3 Promotes C. elegans Germline Development by Regulating Vesicle Trafficking Cytokinesis and Polarity. Curr Biol. 2017;27:868-876 pubmed publisher
    ..Taken together, our data establish CCM-3 as a novel regulator of rachis lumenization and polarity establishment during embryogenesis. ..
  44. Lin J, Xu P, LaVallee P, Hoidal J. Identification of proteins binding to E-Box/Ku86 sites and function of the tumor suppressor SAFB1 in transcriptional regulation of the human xanthine oxidoreductase gene. J Biol Chem. 2008;283:29681-9 pubmed publisher
    ..Moreover, we demonstrate that the cytokine, oncostatin M (OSM), induces the phosphorylation of SAFB1 and that the OSM-induced hXOR mRNA expression is significantly ..
  45. West N, Murphy L, Watson P. Oncostatin M suppresses oestrogen receptor-? expression and is associated with poor outcome in human breast cancer. Endocr Relat Cancer. 2012;19:181-95 pubmed publisher
    ..We hypothesised that the inflammatory cytokine oncostatin M (OSM) can downregulate ER expression in breast cancer...
  46. Zhang Y, Bose T, Unger R, Jansen J, Kirkpatrick C, van den Beucken J. Macrophage type modulates osteogenic differentiation of adipose tissue MSCs. Cell Tissue Res. 2017;369:273-286 pubmed publisher
    ..Secretion of the soluble factors oncostatin M (OSM) and bone morphogenetic protein 2 (BMP-2) by macrophages showed correlation with MSC gene expression ..
  47. Beigel F, Friedrich M, Probst C, Sotlar K, Goke B, Diegelmann J, et al. Oncostatin M mediates STAT3-dependent intestinal epithelial restitution via increased cell proliferation, decreased apoptosis and upregulation of SERPIN family members. PLoS ONE. 2014;9:e93498 pubmed publisher
    b>Oncostatin M (OSM) is produced by activated T cells, monocytes, and dendritic cells and signals through two distinct receptor complexes consisting of gp130 and LIFR (I) or OSMR-? and gp130 (II), respectively...
  48. Basiri A, Amirian P, Mooney P. Using Crowdsourced Trajectories for Automated OSM Data Entry Approach. Sensors (Basel). 2016;16: pubmed publisher
    ..Using these rules successfully results in the generation of new features with higher spatial quality which are subsequently automatically inserted into the OSM database. ..
  49. Sánchez Infantes D, Cereijo R, Peyrou M, Piquer Garcia I, Stephens J, Villarroya F. Oncostatin m impairs brown adipose tissue thermogenic function and the browning of subcutaneous white adipose tissue. Obesity (Silver Spring). 2017;25:85-93 pubmed publisher
    Since oncostatin m (OSM) is elevated in adipose tissue in conditions of obesity and type 2 diabetes in mice and humans, the aim of this study was to determine whether this cytokine plays a crucial role in the impairment of brown adipose ..
  50. Salahub C, Emrich S. ERP evidence for temporal independence of set size and object updating in object substitution masking. Atten Percept Psychophys. 2018;80:387-401 pubmed publisher
    ..Moreover, we found that the early SPCN may reflect disruptions to object consolidation, potentially revealing a neural mechanism supporting an object individuation-through-updating account of OSM. ..
  51. Bright J, De Sabbata S, Lee S, Ganesh B, Humphreys D. OpenStreetMap data for alcohol research: Reliability assessment and quality indicators. Health Place. 2018;50:130-136 pubmed publisher
    ..The ease of access and use may create opportunities for analysts and researchers seeking to understand broad patterns of alcohol availability. ..
  52. Goyden J, Tawara K, Hedeen D, Willey J, Oxford J, Jorcyk C. The Effect of OSM on MC3T3-E1 Osteoblastic Cells in Simulated Microgravity with Radiation. PLoS ONE. 2015;10:e0127230 pubmed publisher
    ..Our lab and others have shown that the IL-6 class cytokine oncostatin M (OSM) is an important regulator of bone remodeling...
  53. Nair M, Suman S, Chatli M, Li S, Joseph P, Beach C, et al. Proteome basis for intramuscular variation in color stability of beef semimembranosus. Meat Sci. 2016;113:9-16 pubmed publisher
    ..These results indicated that differential abundance of sarcoplasmic proteome contributes to intramuscular variations in beef color stability. ..
  54. Egami N, Kakigi A, Takeda T, Yamasoba T. Dehydration effects of a V2 antagonist on endolymphatic hydrops in guinea pigs. Hear Res. 2016;332:151-159 pubmed publisher
    ..These findings suggest that OPC-41061 may be one useful treatment option for EH. ..
  55. Son H, Lee S, Lee S, Kim E, Yang E, Kim J, et al. Oncostatin M Suppresses Activation of IL-17/Th17 via SOCS3 Regulation in CD4+ T Cells. J Immunol. 2017;198:1484-1491 pubmed publisher
    b>Oncostatin M (OSM) is a pleiotropic cytokine and a member of the IL-6 family. It has both proinflammatory and anti-inflammatory functions and is involved in the activation of STAT3 and STAT5...
  56. Nippert F, Schreckenberg R, Schluter K. Isolation and Cultivation of Adult Rat Cardiomyocytes. J Vis Exp. 2017;: pubmed publisher
    ..Key markers in this process of de- and re-differentiation are β-myosin heavy chain (β-MHC), oncostatin M (OSM), and swiprosin-1 (EFHD2)...
  57. Deller M, Hudson K, Ikemizu S, Bravo J, Jones E, Heath J. Crystal structure and functional dissection of the cytostatic cytokine oncostatin M. Structure. 2000;8:863-74 pubmed
    The cytokine oncostatin M (OSM) inhibits growth of certain tumour-derived cells, induces proliferation in other cell types (e.g. haemangioblasts) and is a mediator of inflammatory responses...
  58. Catani J, Medrano R, Hunger A, Del Valle P, Adjemian S, Zanatta D, et al. Intratumoral Immunization by p19Arf and Interferon-? Gene Transfer in a Heterotopic Mouse Model of Lung Carcinoma. Transl Oncol. 2016;9:565-574 pubmed publisher
  59. Crouzet S, Kovalenko L, Del Pin S, Overgaard M, Busch N. Early visual processing allows for selective behavior, shifts of attention, and conscious visual experience in spite of masking. Conscious Cogn. 2017;54:89-100 pubmed publisher
  60. Sweeny T, D Abreu L, Elias E, Padama L. Object-substitution masking weakens but does not eliminate shape interactions. Atten Percept Psychophys. 2017;79:2179-2189 pubmed publisher
  61. Lapeire L, Hendrix A, Lambein K, Van Bockstal M, Braems G, Van Den Broecke R, et al. Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak/STAT3 signaling. Cancer Res. 2014;74:6806-19 pubmed publisher
    ..techniques, including transcriptomics, proteomics, and kinomics enabled us to identify paracrine secretion of oncostatin M (OSM) by cancer-associated adipose tissue...
  62. García Linares S, Palacios Ortega J, Yasuda T, Ã…strand M, Gavilanes J, Martínez del Pozo Ã, et al. Toxin-induced pore formation is hindered by intermolecular hydrogen bonding in sphingomyelin bilayers. Biochim Biophys Acta. 2016;1858:1189-95 pubmed publisher
    ..Our results suggest that other types of protein interactions in bilayers may also be affected by hydrogen-bonding origination from SMs. ..
  63. Jahani Asl A, Yin H, Soleimani V, Haque T, Luchman H, Chang N, et al. Control of glioblastoma tumorigenesis by feed-forward cytokine signaling. Nat Neurosci. 2016;19:798-806 pubmed publisher
    ..Our findings identify OSMR as a critical regulator of glioblastoma tumor growth that orchestrates a feed-forward signaling mechanism with EGFRvIII and STAT3 to drive tumorigenesis. ..
  64. Silva M, Morsci N, Nguyen K, Rizvi A, Rongo C, Hall D, et al. Cell-Specific ?-Tubulin Isotype Regulates Ciliary Microtubule Ultrastructure, Intraflagellar Transport, and Extracellular Vesicle Biology. Curr Biol. 2017;27:968-980 pubmed publisher
    ..These findings provide insight into mechanisms generating ciliary diversity and lay a foundation for further understanding the tubulin code. ..
  65. Gruson D, Ferracin B, Ahn S, Rousseau M. Elevation of plasma oncostatin M in heart failure. Future Cardiol. 2017;13:219-227 pubmed publisher
    b>Oncostatin M (OSM) is an inflammatory cytokine of the gp130 family. OSM could participate in adverse cardiovascular remodeling through regulation of FGF23...
  66. Kucia Tran J, Tulkki V, Scarpini C, Smith S, Wallberg M, Pàez Ribes M, et al. Anti-oncostatin M antibody inhibits the pro-malignant effects of oncostatin M receptor over-expression in squamous cell carcinoma. J Pathol. 2017;: pubmed publisher
    The oncostatin M receptor (OSMR) shows frequent gene copy-number gain and over-expression in cervical squamous cell carcinomas (SCCs), associated with adverse clinical outcomes...
  67. Mahboubi K, Pober J. Activation of signal transducer and activator of transcription 1 (STAT1) is not sufficient for the induction of STAT1-dependent genes in endothelial cells. Comparison of interferon-gamma and oncostatin M. J Biol Chem. 2002;277:8012-21 pubmed
    We compared human endothelial cell (EC) responses to interferon-gamma (IFN gamma) and oncostatin M (OnM), cytokines that utilize Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling...
  68. Kurosawa T, Yamada A, Suzuki D, Morimura N, Sasagane Y, Itabe H, et al. Nephronectin Expression Is Up-Regulated by BMP-2. Biol Pharm Bull. 2016;39:1211-5 pubmed publisher
    ..by various cytokines, including transforming growth factor-? (TGF-?), tumor necrosis factor-? (TNF-?), and oncostatin M (OSM), and that over-expression of Npnt enhanced osteoblast differentiation...
  69. Khansai M, Boonmaleerat K, Pothacharoen P, Phitak T, Kongtawelert P. Ex vivo model exhibits protective effects of sesamin against destruction of cartilage induced with a combination of tumor necrosis factor-alpha and oncostatin M. BMC Complement Altern Med. 2016;16:205 pubmed publisher
    ..The model could be used to test for the prevention of cartilage degradation in other biological agents induced with TNF-? and OSM as well. ..
  70. Chen Z, Chen L, Liu R, Lin Y, Chen S, Lu S, et al. The osteoimmunomodulatory property of a barrier collagen membrane and its manipulation via coating nanometer-sized bioactive glass to improve guided bone regeneration. Biomater Sci. 2018;6:1007-1019 pubmed publisher
    ..New generation barrier membranes should be designed with a favourable osteoimmunomodulatory property. ..
  71. Rose T, Bruce A. Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. Proc Natl Acad Sci U S A. 1991;88:8641-5 pubmed
    b>Oncostatin M (OSM), a glycoprotein of Mr approximately 28,000 produced by activated monocyte and T-lymphocyte cell lines, was previously identified by its ability to inhibit the growth of cells from melanoma and other solid tumors...
  72. Larrea E, Echeverria I, Riezu Boj J, Aldabe R, Guembe L, Sola I, et al. Characterization of the CD40L/Oncostatin M/Oncostatin M receptor axis as an antiviral and immunostimulatory system disrupted in chronic HCV infection. J Hepatol. 2014;60:482-9 pubmed publisher
    b>Oncostatin M (OSM) is an inflammatory cytokine which interacts with a heterodimeric receptor formed by gp130 and either OSMR? or LIFR...
  73. Katsoufi S, Lazou A, Giannakourou M, Krokida M. Mass transfer kinetics and quality attributes of osmo-dehydrated candied pumpkins using nutritious sweeteners. J Food Sci Technol. 2017;54:3338-3348 pubmed publisher
    ..Both hardness and compression work decreased until an equilibrium value was reached as time and temperature of the process increased, regardless the osmotic agent used...
  74. Mirshahi F, Vasse M, Tedgui A, Li H, Merval R, Legrand E, et al. Oncostatin M induces procoagulant activity in human vascular smooth muscle cells by modulating the balance between tissue factor and tissue factor pathway inhibitor. Blood Coagul Fibrinolysis. 2002;13:449-55 pubmed
    b>Oncostatin M (OSM) is a cytokine of the interleukin-6 (IL-6) family secreted by activated monocytes, and is expressed in atherosclerotic plaque...
  75. McKenzie G, Janowicz K. ISED: Constructing a high-resolution elevation road dataset from massive, low-quality in-situ observations derived from geosocial fitness tracking data. PLoS ONE. 2017;12:e0186474 pubmed publisher
    ..75m RMSE compared to the base line. We utilize Linked Data technologies to integrate the proposed high-resolution dataset with OpenStreetMap road geometries without requiring any changes to the OSM data model...
  76. Mukherjee S, Sengupta Bandyopadhyay S. Phorbol-12-myristate-13-acetate (PMA) mediated transcriptional regulation of Oncostatin-M. Cytokine. 2016;88:209-213 pubmed publisher
    ..Knockdown of C/EBP-β also leads to inhibition of PMA-mediated OSM induction. ..
  77. West N, Hegazy A, Owens B, Bullers S, Linggi B, Buonocore S, et al. Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease. Nat Med. 2017;23:579-589 pubmed publisher
    ..to healthy controls, inflamed intestinal tissues from patients with IBD express high amounts of the cytokine oncostatin M (OSM) and its receptor (OSMR), which correlate closely with histopathological disease severity...
  78. Suda T, Chida K, Todate A, Ide K, Asada K, Nakamura Y, et al. Oncostatin M production by human dendritic cells in response to bacterial products. Cytokine. 2002;17:335-40 pubmed
    b>Oncostatin M (OSM) is a pleiomorphic cytokine that belongs to the IL-6 cytokine family. It is produced by activated T cells and monocytes/macrophages and plays an important role in the process of inflammatory responses...
  79. Yu M, Kissling S, Freyschmidt Paul P, Hoffmann R, Shapiro J, McElwee K. Interleukin-6 cytokine family member oncostatin M is a hair-follicle-expressed factor with hair growth inhibitory properties. Exp Dermatol. 2008;17:12-9 pubmed
    ..5-fold) and oncostatin M (OSM, 3.4-fold) in hair follicles...
  80. Krona A, Järnum S, Salford L, Widegren B, Aman P. Oncostatin M signaling in human glioma cell lines. Oncol Rep. 2005;13:807-11 pubmed
    We have recently found that oncostatin M (OSM) is overexpressed in most human brain tumors. The effects of OSM are unclear with conflicting reports of growth stimulatory or inhibitory effects in various cell types...
  81. Yanpeng W, Qiongxiao H, Sheng X, Jing S. [Establishment of mouse endometrial injury model by curettage or coagulation]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2017;46:186-191 pubmed
    ..The expressions of leukemia inhibitory factor (LIF) and oncostatin M (OSM) were significantly reduced on injured side in both groups compared to opposite side; however, the ..
  82. Holmstrup M, Slotsbo S. Combined effects of drought and cold acclimation on phospholipid fatty acid composition and cold-shock tolerance in the springtail Protaphorura fimata. J Comp Physiol B. 2018;188:225-236 pubmed publisher
    ..We discuss the possible roles of drought-induced compatible osmolytes and an altered PLFA composition in the cold-shock tolerance of arthropods. ..
  83. Hintzen C, Haan C, Tuckermann J, Heinrich P, Hermanns H. Oncostatin M-induced and constitutive activation of the JAK2/STAT5/CIS pathway suppresses CCL1, but not CCL7 and CCL8, chemokine expression. J Immunol. 2008;181:7341-9 pubmed
    ..In this study, we show that oncostatin M, a member of the IL-6-type cytokine family and potent proinflammatory cytokine stimulates the expression of the ..
  84. Pan C, Wang M, Chiou S, Chen H, Wu C. Oncostatin M suppresses metastasis of lung adenocarcinoma by inhibiting SLUG expression through coordination of STATs and PIASs signalings. Oncotarget. 2016;7:60395-60406 pubmed publisher
    b>Oncostatin M (OSM) is linked with multiple biological responses including growth and differentiation. Previous reports showed inhibitory effects of OSM in tumor progression while others showed promoting effects...
  85. Junk D, Bryson B, Smigiel J, Parameswaran N, Bartel C, Jackson M. Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling. Oncogene. 2017;36:4001-4013 pubmed publisher
    ..Of 28 TME cytokines and growth factors tested, we identified Oncostatin M (OSM) as the most potent inducer of mesenchymal/CSC properties...
  86. Ko H, Kang H, Kim H, Choi S, Park I, Shin J. The effects of oncostatin M on trophoblast cells: influence on matrix metalloproteinases-2 and -9, and invasion activity. Placenta. 2012;33:908-13 pubmed publisher
    b>Oncostatin M (OSM), a cytokine of the interleukin-6 (IL-6) family, can either promote or inhibit cell growth in various normal and tumor cells and is expressed in rheumatoid arthritis, multiple sclerosis, multiple myeloma, and other ..
  87. Canady J, Arndt S, Karrer S, Bosserhoff A. Increased KGF expression promotes fibroblast activation in a double paracrine manner resulting in cutaneous fibrosis. J Invest Dermatol. 2013;133:647-657 pubmed publisher
    ..Upon KGF stimulation, the keratinocytes produced and secreted OSM (oncostatin M)...
  88. He W, Gong K, Smith D, Ip N. The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signaling. FEBS Lett. 2005;579:4317-23 pubmed
    ..We show here that signaling by CNTF, but not by LIF or oncostatin M (OSM), was abolished in cells overexpressing a LIFR mutant with the N-terminal cytokine binding domain deleted...
  89. Diveu C, Venereau E, Froger J, Ravon E, Grimaud L, Rousseau F, et al. Molecular and functional characterization of a soluble form of oncostatin M/interleukin-31 shared receptor. J Biol Chem. 2006;281:36673-82 pubmed
    Activation of the signaling transduction pathways mediated by oncostatin M (OSM) requires the binding of the cytokine to either type I OSM receptor (leukemia inhibitory factor receptor/gp130) or to type II OSM receptor (OSMR/gp130)...
  90. Pellitero S, Piquer Garcia I, Ferrer Curriu G, Puig R, Martinez E, Moreno P, et al. Opposite changes in meteorin-like and oncostatin m levels are associated with metabolic improvements after bariatric surgery. Int J Obes (Lond). 2018;42:919-922 pubmed publisher
    ..Here we studied the effects of bariatric surgery on circulating meteorin-like (Metrnl) and oncostatin m (OSM) levels, two hormones intimately linked to energy homeostasis...
  91. Chipoy C, Brounais B, Trichet V, Battaglia S, Berreur M, Oliver L, et al. Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53. Oncogene. 2007;26:6653-64 pubmed
    b>Oncostatin M (OSM), a cytokine of the interleukin-6 family, induces growth arrest and differentiation of osteoblastic cells into glial-like/osteocytic cells...
  92. Thorat Manojkumar S, Pradeep A, Garg G, Raju A. Gingival crevicular fluid levels of oncostatin M in periodontal conditions. Cytokine. 2010;50:248-52 pubmed publisher
    The initial study has reported the increased level of oncostatin M (OSM) in gingival crevicular fluid (GCF) of chronic periodontitis patients, and no study has reported its level in gingivitis patients...