Gene Symbol: ODAPH
Description: odontogenesis associated phosphoprotein
Alias: AI2A4, C4orf26, odontogenesis associated phosphoprotein, amelogenesis imperfecta type IIA4, uncharacterized protein C4orf26
Parry D, Brookes S, Logan C, Poulter J, El Sayed W, Al Bahlani S, et al
. Mutations in C4orf26, encoding a peptide with in vitro hydroxyapatite crystal nucleation and growth activity, cause amelogenesis imperfecta. Am J Hum Genet. 2012;91:565-71 pubmed publisher
Autozygosity mapping and clonal sequencing of an Omani family identified mutations in the uncharacterized gene, C4orf26, as a cause of recessive hypomineralized amelogenesis imperfecta (AI), a disease in which the formation of tooth ..
Springer M, Starrett J, Morin P, Lanzetti A, Hayashi C, Gatesy J. Inactivation of C4orf26 in toothless placental mammals. Mol Phylogenet Evol. 2016;95:34-45 pubmed publisher
..for edentulous and enamelless mammals to evaluate the enamel specificity of four genes (WDR72, SLC24A4, FAM83H, C4orf26) that have been implicated in amelogenesis imperfecta, a condition in which proper enamel formation is abrogated ..
Chung S, Armasu S, Biernacka J, Anderson K, Lesnick T, Rider D, et al
. Genomic determinants of motor and cognitive outcomes in Parkinson's disease. Parkinsonism Relat Disord. 2012;18:881-6 pubmed publisher
..This study suggests that common variants in several genes may be associated with motor and cognitive outcomes in PD, with biological plausibility. ..
Prasad M, Laouina S, El Alloussi M, Dollfus H, Bloch Zupan A. Amelogenesis Imperfecta: 1 Family, 2 Phenotypes, and 2 Mutated Genes. J Dent Res. 2016;95:1457-1463 pubmed
..1873C>T, p.R625*) segregating with hypoplastic AI and a novel homozygous 8-bp deletion in C4orf26 (c.39_46del, p.Cys14Glyfs*18) segregating with hypomineralized-hypoplastic AI in this family...