Genomes and Genes
Gene Symbol: OCLN
Alias: BLCPMG, tight junction protein occludin
- Alteration of tight junction proteins is an early event in psoriasis: putative involvement of proinflammatory cytokinesNina Kirschner
Department of Dermatology and Venerology, University Hospital Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
Am J Pathol 175:1095-106. 2009..Our data indicate that cytokines are involved in alterations of TJ proteins observed in psoriasis...
- Epidermal tight junctions: ZO-1 and occludin are expressed in mature, developing, and affected skin and in vitro differentiating keratinocytesK Pummi
Department of Medical Biochemistry, University of Turku, Finland
J Invest Dermatol 117:1050-8. 2001..We speculate that the epidermal barrier, isolating the human body from the external environment, is in part formed by tight junctions of stratum granulosum...
- Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functionsDavid R Raleigh
Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
Mol Biol Cell 21:1200-13. 2010..The data further suggest that these proteins are best considered as a group with both redundant and unique contributions to epithelial function and tight junction regulation...
- The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady stateLe Shen
Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
J Cell Biol 181:683-95. 2008..These data demonstrate that the tight junction undergoes constant remodeling and suggest that this dynamic behavior may contribute to tight junction assembly and regulation...
- ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludinJ Haskins
Department of Cell Biology and Anatomy, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
J Cell Biol 141:199-208. 1998..In vitro affinity analyses demonstrated that recombinant 130-kD protein directly interacts with ZO-1 and the cytoplasmic domain of occludin, but not with ZO-2. We propose that this protein be named ZO-3...
- Species-specific regions of occludin required by hepatitis C virus for cell entryMaria L Michta
Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
J Virol 84:11696-708. 2010..It has been previously determined that the tight junction protein occludin (OCLN) is essential for HCV host cell entry and that human OCLN is more efficient than the mouse ..
- Redox-sensitivity of the dimerization of occludinJ K Walter
Leibniz Institut für Molekulare Pharmakologie Berlin, FMP, Robert Rossle Str 10, 13125, Berlin Buch, Germany
Cell Mol Life Sci 66:3655-62. 2009..It is concluded that the redox-dependent dimerization of occludin may play a regulatory role in the tight junction assembly under physiological and pathological conditions...
- Different expression of occludin and ZO-1 in primary and metastatic liver tumorsErika Orbán
2nd Department of Pathology, Semmelweis University, Budapest, Hungary
Pathol Oncol Res 14:299-306. 2008..HCCs and metastases are characterized by markedly different protein expression pattern of occludin and ZO-1, which phenomenon might be attributed to the different histogenesis of these tumors...
- Differential phosphorylation of occludin and tricellulin by CK2 and CK1Max J Dörfel
Department of Laboratory Medicine and Pathobiochemistry, Charite Universitatsmedizin Berlin, Berlin, Germany
Ann N Y Acad Sci 1165:69-73. 2009..This chapter compares occludin and tricellulin phosphorylation by the serine/threonine kinases CK2 and CK1...
- Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfectionShufeng Liu
Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pennsylvania, USA
J Virol 83:2011-4. 2009..The altered TJ protein expression may contribute to the morphological and functional changes observed in HCV-infected hepatocytes...
- Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudinsM Itoh
Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
J Cell Biol 147:1351-63. 1999..In good agreement, PDZ1 and PDZ2 domains of ZO-1/ZO-2/ZO-3 were also recruited to claudin-based TJs, when introduced into cultured epithelial cells. The possible molecular architecture of TJ plaque structures is discussed...
- Occludin phosphorylation: identification of an occludin kinase in brain and cell extracts as CK2Caroline Smales
Eisai London Research Laboratories Ltd, Bernard Katz Building, University College London, Gower Street, London, WC1E 6BT, UK
FEBS Lett 545:161-6. 2003..CK2 is therefore a candidate kinase for regulation of occludin phosphorylation in vivo...
- HIV-1 gp120 proteins alter tight junction protein expression and brain endothelial cell permeability: implications for the pathogenesis of HIV-associated dementiaGeorgette D Kanmogne
Department of Pharmacology, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5215, USA
J Neuropathol Exp Neurol 64:498-505. 2005....
- Zonula occludens-1, occludin, and E-cadherin protein expression in biliary tract cancersZsuzsanna Nemeth
2nd Department of Pathology, Semmelweis University, Ulloi ut 93, H 1091 Budapest, Hungary
Pathol Oncol Res 15:533-9. 2009..These results were confirmed by discriminant analysis yielding clear separation of the three normal sample groups from carcinomas in the corresponding locations...
- Identification and analysis of occludin phosphosites: a combined mass spectrometry and bioinformatics approachJeffrey M Sundstrom
Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
J Proteome Res 8:808-17. 2009..This study demonstrates that combining MS data and bioinformatics can successfully identify novel phosphorylation sites from limiting samples...
- Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctionsBertha C Elias
Department of Physiology, Charles B Stout Neuroscience Mass Spectrometry Laboratory, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
J Biol Chem 284:1559-69. 2009..This study reveals a unique motif in the occludin sequence that is involved in the regulation of ZO-1 binding by reversible phosphorylation of specific Tyr residues...
- Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha cateninM Itoh
Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
J Biol Chem 274:5981-6. 1999..These findings indicated that ZO-2 forms a complex with ZO-1/occludin or ZO-1/alpha catenin to establish TJ or AJ domains, respectively...
- The second extracellular loop dictates Occludin-mediated HCV entryShufeng Liu
Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
Virology 407:160-70. 2010Recent findings have implicated tight junction (TJ) protein Occludin (OCLN) as an essential factor for hepatitis C virus (HCV) to enter human hepatocytes...
- The tight junction-associated protein occludin is required for a postbinding step in hepatitis C virus entry and infectionIgnacio Benedicto
Hospital Universitario de la Princesa, Madrid, Spain
J Virol 83:8012-20. 2009..In summary, we propose that occludin plays an essential role in HCV infection and probably affects late entry events. This observation may provide new insights into HCV infection and related pathogenesis...
- Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5Carolyn B Coyne
Division of Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Cell Host Microbe 2:181-92. 2007..Thus, CVB entry depends on occludin and occurs by a process that combines aspects of caveolar endocytosis with features characteristic of macropinocytosis...
- Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3E S Wittchen
Department of Cell Biology, University of Alberta, Edmonton T6G 2H7, Canada
J Biol Chem 274:35179-85. 1999..ZO-3 complexes rather than a trimeric ZO-1.ZO-2.ZO-3 grouping. These studies elucidate direct binding interactions among tight junction-associated proteins, giving insight into their organization as a multimolecular structure...
- Use of surface plasmon resonance for real-time analysis of the interaction of ZO-1 and occludinA Schmidt
Institute of Molecular Pharmacology, Robert Rossle Strasse 10, 13125 Berlin, Germany
Biochem Biophys Res Commun 288:1194-9. 2001..We demonstrate the use of SPR spectroscopy as an effective approach for characterisation of the interactions of junction proteins...
- Occludin expression decreases with the progression of human endometrial carcinomaHirotoshi Tobioka
Department of Pathology, Sapporo Medical University School of Medicine, Japan
Hum Pathol 35:159-64. 2004..These results suggest that the loss of tight junctions has a close relationship with structural atypia in the progression of human endometrial carcinomas and their malignant potential...
- Occludin is required for cytokine-induced regulation of tight junction barriersChristina M Van Itallie
Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
J Cell Sci 123:2844-52. 2010..These results demonstrate that occludin is required for cells to transduce cytokine-mediated signals that either increase the electrical barrier or decrease the large solute barrier, possibly by coordinating the functions of caveolin-1...
- A novel splice variant of occludin deleted in exon 9 and its role in cell apoptosis and invasionJin Mo Gu
Department of Biological Sciences and Seoul National University, 56 1 Shillim dong, Kwanak gu, Seoul, Korea
FEBS J 275:3145-56. 2008The tight junction protein occludin participates in cell adhesion and migration and has been shown to possess antitumorigenic properties; however, the exact mechanism underlying these effects is poorly understood...
- Structure of the conserved cytoplasmic C-terminal domain of occludin: identification of the ZO-1 binding surfaceYuanhe Li
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
J Mol Biol 352:151-64. 2005..Our results provide a model to further test the function of occludin and its binding to other proteins...
- The second loop of occludin is required for suppression of Raf1-induced tumor growthZili Wang
Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, 615 Michael Street, Atlanta, GA 30322, USA
Oncogene 24:4412-20. 2005..These results demonstrate that the TJ protein occludin has a potent inhibitory effect on the Raf1-mediated tumorigenesis, and the second extracellular loop of occludin appears to be critical for this function...
- The tight junction-specific protein occludin is a functional target of the E3 ubiquitin-protein ligase itchAndreas Traweger
Institute of Molecular Biology, Austrian Academy of Sciences, 5020 Salzburg, Austria
J Biol Chem 277:10201-8. 2002..In addition, we provide evidence that Itch is specifically involved in the ubiquitination of occludin in vivo, and that the degradation of occludin is sensitive to proteasome inhibition...
- In vitro protein complex formation with cytoskeleton-anchoring domain of occludin identified by limited proteolysisBi Hung Peng
Department of Pathology, The University of Texas Medical Branch, Galveston, Texas 77555 0750, USA
J Biol Chem 278:49644-51. 2003..These results provide a basis for development of a structural model of the ZO-binding site that can be used to investigate regulation of tight junction anchoring by intracellular signaling events...
- Occludin confers adhesiveness when expressed in fibroblastsC M Van Itallie
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
J Cell Sci 110:1113-21. 1997..These results suggest that the extracellular surface of occludin is directly involved in cell-cell adhesion and the ability to confer adhesiveness correlates with the ability to colocalize with its cytoplasmic binding protein, ZO-1...
- Occludin TM4(-): an isoform of the tight junction protein present in primates lacking the fourth transmembrane domainM Reza Ghassemifar
Division of Cell Sciences, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK Department of Biology, University of York, PO Box 373, York YO10 5YW, UK
J Cell Sci 115:3171-80. 2002The tight junction protein occludin possesses four transmembrane domains, two extracellular loops, and cytoplasmic N- and C-termini...
- The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeletonA S Fanning
Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut 06510, USA
J Biol Chem 273:29745-53. 1998..These observations suggest that one functional role of ZO-1 is to organize components of the tight junction and link them to the cortical actin cytoskeleton...
- Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologuesY Ando-Akatsuka
Department of Cell Biology, Faculty of Medicine, Kyoto University, Japan
J Cell Biol 133:43-7. 1996..Implications of these data and novel experimental options in cell biological research are discussed...
- Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctionsM Furuse
Department of Information Physiology, National Institute for Physiological Sciences, Okazaki, Aichi, Japan
J Cell Biol 127:1617-26. 1994..The coincidence of the sequence necessary for the ZO-1 association with that for the TJ localization suggests that the association with underlying cytoskeletons through ZO-1 is required for occludin to be localized at TJ...
- VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdownAzeb Tadesse Argaw
Corinne Goldsmith Dickinson Center for Multiple Sclerosis and Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
Proc Natl Acad Sci U S A 106:1977-82. 2009..Here, we identify the endothelial transmembrane tight junction proteins claudin-5 (CLN-5) and occludin (OCLN) as targets of VEGF-A action...
- A novel rearrangement of occludin causes brain calcification and renal dysfunctionMarissa A LeBlanc
Department of Pathology, Dalhousie University, 5850 College St, Sir Charles Tupper Medical Building, Room 11 F, Halifax, NS, Canada
Hum Genet 132:1223-34. 2013..describe the identification of a novel rearrangement in which a downstream pseudogene translocates into exon 9 of OCLN, resulting in band-like brain calcification and advanced chronic kidney disease in early childhood...
- Tight junction regulation by morphine and HIV-1 tat modulates blood-brain barrier permeabilitySupriya D Mahajan
Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Buffalo General Hospital, 301 Multi Research Bldg, 100 High Street, Buffalo, NY 14203, USA
J Clin Immunol 28:528-41. 2008..These studies may lead to the development of novel anti-HIV-1 therapeutics that target specific TJ proteins, thus preventing TJ disruption in opiate using HIV-1 patients...
- Epithelial permeability alterations in an in vitro air-liquid interface model of allergic fungal rhinosinusitisKyle A Den Beste
Epithelial Pathobiology and Mucosal Inflammation Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30308, USA
Int Forum Allergy Rhinol 3:19-25. 2013..The aim of this study was to compare epithelial permeability and intercellular junctional protein expression among cultured primary sinonasal cells from AFRS patients vs noninflammatory controls...
- The occludin and ZO-1 complex, defined by small angle X-ray scattering and NMR, has implications for modulating tight junction permeabilityBrian R Tash
Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, H171, 500 University Drive, Hershey, PA 17033, USA
Proc Natl Acad Sci U S A 109:10855-60. 2012..This model has important implications for the phosphorylation-dependent regulation of the occludin:ZO-1 complex...
- Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeabilityTomoaki Murakami
Department of Cellular and Molecular Physiology and Ophthalmology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
J Biol Chem 284:21036-46. 2009..These data demonstrate a novel mechanism of VEGF-induced occludin phosphorylation and ubiquitination that contributes to TJ trafficking and subsequent vascular permeability...
- Breaking down the barrier: the effects of HIV-1 on the blood-brain barrierMarianne Strazza
Department of Microbiology and Immunology, and Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19102, USA
Brain Res 1399:96-115. 2011....
- Interleukin-18 facilitates neutrophil transmigration via myosin light chain kinase-dependent disruption of occludin, without altering epithelial permeabilityTamia K Lapointe
Dept of Biological Sciences, Univ of Calgary, Calgary, AB, Canada
Am J Physiol Gastrointest Liver Physiol 302:G343-51. 2012..In conclusion, our data suggest that IL-18 may potentiate inflammation in the context of IBD by facilitating neutrophil transepithelial migration via MLCK-dependent disruption of tight junctional occludin...
- Methamphetamine alters blood brain barrier permeability via the modulation of tight junction expression: Implication for HIV-1 neuropathogenesis in the context of drug abuseSupriya D Mahajan
Department of Medicine, Division of Allergy, Immunology, and Rheumatology, 301 Multi Research Building, Buffalo General Hospital, 100 High Street, Buffalo, NY 14203, USA
Brain Res 1203:133-48. 2008..An understanding of the mechanisms of BBB breakdown that lead to neurotoxicity is crucial to the development of therapeutic modalities for Meth abusing HAD patients...
- Caveolin-1 regulates human immunodeficiency virus-1 Tat-induced alterations of tight junction protein expression via modulation of the Ras signalingYu Zhong
Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery, University of Kentucky, Lexington, Kentucky 40536, USA
J Neurosci 28:7788-96. 2008..Thus, caveolin-1 may provide an effective target to protect against Tat-induced HBMEC dysfunction and the disruption of the BBB in HIV-1-infected patients...
- Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cellsJennifer L Sallee
Department of Cell and Developmental Biology and Lineberger Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Biol Chem 284:14997-5006. 2009..These data suggest that DEP-1 can modify the phosphorylation state of tight junction proteins and play a role in regulating permeability...
- Induction of tight junctions in human connexin 32 (hCx32)-transfected mouse hepatocytes: connexin 32 interacts with occludinT Kojima
Department of Neuroscience, Albert Einstein College of Medicine, New York, NY, USA
Biochem Biophys Res Commun 266:222-9. 1999..Immunocytochemistry revealed that endogenous integral tight junction protein occludin was strongly localized and was colocalized with Cx32 at cell borders in transfectants, whereas ..
- Impact of intra- and interspecies variation of occludin on its function as coreceptor for authentic hepatitis C virus particlesSandra Ciesek
Medizinische Hochschule Hannover, Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Carl Neuberg Str 1, 30625 Hannover, Germany
J Virol 85:7613-21. 2011..The tight junction component occludin (OCLN) is essential for HCV entry into host cells, and the differences between human and murine OCLN are thought to ..
- The tight junction protein, occludin, regulates the directional migration of epithelial cellsDan Du
State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Dev Cell 18:52-63. 2010..Our data indicate that occludin is required for the leading-edge localization of polarity proteins aPKC-Par3 and PATJ and promotes cell protrusion by regulating membrane-localized activation of PI3K...
- Expression of human factors CD81, claudin-1, scavenger receptor, and occludin in mouse hepatocytes does not confer susceptibility to HCV entryKeisuke Hikosaka
Department of Biochemistry, Hamamatsu University School of Medicine, Handa yama, Higashi ku, Hamamatsu, Shizuoka, Japan
Biomed Res 32:143-50. 2011..Our results suggest that the expression of the human factors does not confer susceptibility to HCV entry into the liver...
- Recessive mutations in the gene encoding the tight junction protein occludin cause band-like calcification with simplified gyration and polymicrogyriaMary C O'Driscoll
University of Manchester, Manchester Academic Health Science Centre, Central Manchester Foundation Trust University Hospitals, UK
Am J Hum Genet 87:354-64. 2010..We provide evidence that the tight junction protein occludin (encoded by the OCLN gene) is involved in the pathogenesis of malformations of cortical development.
- Loss of occludin leads to the progression of human breast cancerTracey A Martin
Metastasis and Angiogenesis Research Group, Department of Surgery, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
Int J Mol Med 26:723-34. 2010..This loss of or aberrant expression has clear repercussions as to the importance of occludin in maintaining TJ integrity in breast tissues. Such inappropriate expression could play a part in breast cancer development...
- Transcriptional control of occludin expression in vascular endothelia: regulation by Sp3 and YY1Hadassah Sade
Department of Life Sciences, The Open University, Milton Keynes, MK7 6AA, UK
Biochim Biophys Acta 1789:175-84. 2009..The promoter of the tight junction protein occludin exhibited strong activity in a brain endothelial cell line, hCMEC/D3 but was inactive in lung ..
- PKC eta regulates occludin phosphorylation and epithelial tight junction integrityTakuya Suzuki
Department of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, Memphis, TN 38163, USA
Proc Natl Acad Sci U S A 106:61-6. 2009..These results reveal an important mechanism of epithelial TJ regulation by PKC eta...
- Influence of protein kinase C on transcription of the tight junction elements ZO-1 and occludinFrank Weiler
Department of Medicine, Division of Gastroenterology, University of Wuerzburg, Wuerzburg, Germany
J Cell Physiol 204:83-6. 2005..Overall ZO-1 and occludin seem to be identically regulated in colonic epithelium on the transcript level...
- The specific fates of tight junction proteins in apoptotic epithelial cellsChristian Bojarski
Institute of Clinical Chemistry and Pathobiochemistry, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
J Cell Sci 117:2097-107. 2004..While the amount of claudin-2 protein was reduced similarly to occludin, ZO-1 and ZO-2, claudin-1 was either fully preserved or was even increased in apoptotic cells...
- Immunohistological distribution of the tight junction components ZO-1 and occludin in regenerating human epidermisM Malminen
Department of Medical Biochemistry, University of Turku, Kiinamyllynkatu 4 8, 20520 Turku, Finland
Br J Dermatol 149:255-60. 2003..Tight junctions have recently been characterized in the granular cell layer of human epidermis, and the role of these junctions in the epidermal barrier is now being re-evaluated...
- Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by SnailJunichi Ikenouchi
Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
J Cell Sci 116:1959-67. 2003..e. the expression of adherens and tight junction adhesion molecules, respectively)...
- Co-localization of junction-associated proteins of the human blood--aqueous barrier: occludin, ZO-1 and F-actinJeffrey Sonsino
Department of Biosciences, New England College of Optometry, Boston, MA 02118, USA
Exp Eye Res 74:123-9. 2002....
- Occludin expression in microvessels of neoplastic and non-neoplastic human brainM C Papadopoulos
Department of Neurosurgery, Atkinson Morley s Hospital, London SW20 0NE, UK
Neuropathol Appl Neurobiol 27:384-95. 2001The tight junction protein occludin 'glues' normal, adjacent brain microvessel endothelial cells together...
- Expression of ZO-1 and occludin in normal human placenta and in hydatidiform molesD Marzioni
Institute of Normal Human Morphology, Faculty of Medicine, University of Ancona, Via Tronto, 10 A, I 60020 Ancona, Italy
Mol Hum Reprod 7:279-85. 2001..The down-regulation and/or dysregulation of these two molecules may be related to phenotypic changes associated with epithelial cell transformation of the chorionic villi in partial and complete moles...
- CaCo-2 cells treated with Clostridium perfringens enterotoxin form multiple large complex species, one of which contains the tight junction protein occludinU Singh
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Biol Chem 275:18407-17. 2000....
- Analysis of tight junctions during neutrophil transendothelial migrationA R Burns
Cardiovascular Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
J Cell Sci 113:45-57. 2000..Collectively, these results suggest that PMN migration at tricellular corners preserves the barrier properties of the endothelium and does not involve widespread disruption of endothelial TJs...
- Mammalian occludin in epithelial cells: its expression and subcellular distributionM Saitou
Department of Cell Biology, Faculty of Medicine, Kyoto University, Japan
Eur J Cell Biol 73:222-31. 1997..Furthermore, the exclusive concentration of occludin at tight junctions in epithelial cells was confirmed by immunoreplica electron microscopy...
- Estrogen decrease in tight junctional resistance involves matrix-metalloproteinase-7-mediated remodeling of occludinGeorge I Gorodeski
Department of Reproductive Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Endocrinology 148:218-31. 2007..These mechanisms acting in concert could be important for regulation and control of estrogen modulation of paracellular permeability in vivo...
- Enhanced tight junction function in human breast cancer cells by antioxidant, selenium and polyunsaturated lipidTracey A Martin
Metastasis and Angiogenesis Research Group, Department of Surgery, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
J Cell Biochem 101:155-66. 2007..This combination also completely reversed the effect of 17-beta-estradiol in these cells...
- Tight junction proteins in gallbladder epithelium: different expression in acute acalculous and calculous cholecystitisJouko J Laurila
Department of Anesthesiology, Oulu University Hospital, P O Box 21, Oulu, Finland, 90029
J Histochem Cytochem 55:567-73. 2007....
- Human protein factory for converting the transcriptome into an in vitro-expressed proteome,Naoki Goshima
National Institute of Advanced Industrial Science and Technology, 2 42 Aomi, Koto ku, Tokyo 135 0064, Japan
Nat Methods 5:1011-7. 2008..Our 'human protein factory' infrastructure includes the resources and expression technology for in vitro proteome research...
- Hepatitis C virus envelope components alter localization of hepatocyte tight junction-associated proteins and promote occludin retention in the endoplasmic reticulumIgnacio Benedicto
Molecular Biology Unit, Hospital Universitario de la Princesa, Madrid, Spain
Hepatology 48:1044-53. 2008..Additionally, using a cell culture model of HCV infection, we observed the cytoplasmic dot-like accumulation of occludin in infected Huh7 cells...
- Glucocorticoids regulate the human occludin gene through a single imperfect palindromic glucocorticoid response elementNina Harke
Institute of Anatomy and Cell Biology, University of Wurzburg, Koellikerstr 6, D 97070 Wurzburg, Germany
Mol Cell Endocrinol 295:39-47. 2008....
- Expression of occludin and claudins 1, 3, 4, and 7 in urothelial carcinoma of the upper urinary tractKuniaki Nakanishi
Department of Pathology and Laboratory Medicine, National Defense Medical College, Tokorozawa, Japan
Am J Clin Pathol 130:43-9. 2008..Detection of claudins 1, 3, and 4 would seem to provide valuable information about the progression of UC-UUT...
- Disturbed expression of E-cadherin, beta-catenin and tight junction proteins in colon carcinoma is unrelated to growth pattern and genetic polymorphismsVictoria Hahn-Strömberg
Dept of Clinical Medicine, Orebro University, Orebro, Orebro, Sweden
APMIS 116:253-62. 2008..Rather, aberrations in the function of other proteins related to the adhesive proteins could be responsible...
- MAPK interacts with occludin and mediates EGF-induced prevention of tight junction disruption by hydrogen peroxideShyamali Basuroy
Department of Physiology, University of Tennessee Health Science Center, Memphis, TN, USA
Biochem J 393:69-77. 2006..Therefore the present study shows that ERK interacts with the C-terminal region of occludin and mediates the prevention of H2O2-induced disruption of TJs by EGF...
- Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatographyGuanghui Han
National Chromatographic R and A Center, Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian, China
Proteomics 8:1346-61. 2008..This resulted in the highly confident identification of 274 phosphorylation sites from 305 unique phosphopeptides corresponding to 168 proteins at false discovery rate (FDR) of 0.96%...
- Cellular and molecular mechanisms of heat stress-induced up-regulation of occludin protein expression: regulatory role of heat shock factor-1Karol Dokladny
Internal Medicine Gastroenterology and Hepatology, MSC10 5550, 1 University of New Mexico, Albuquerque, NM 87131 0001, USA
Am J Pathol 172:659-70. 2008....
- A protein kinase A-dependent mechanism by which rotavirus affects the distribution and mRNA level of the functional tight junction-associated protein, occludin, in human differentiated intestinal Caco-2 cellsIsabelle Beau
Faculte de Pharmacie, INSERM Unit 510, Chatenay Malabry, France 92296
J Virol 81:8579-86. 2007....
- Tight junction proteins in keratinocytes: localization and contribution to barrier functionTakuo Yuki
Basic Research Laboratory, Kanebo Cosmetics Inc, Kanagawa, Japan
Exp Dermatol 16:324-30. 2007..We also found that the addition of ochratoxin A weakened the permeability barrier and the expression of claudin-4. Our findings suggest that TJ proteins contribute to the permeability barrier in epidermal keratinocytes...
- Expression of occludin, tight-junction-associated protein, in human digestive tractY Kimura
Department of Surgery II, Osaka University Medical School, Japan
Am J Pathol 151:45-54. 1997..In addition, occludin expression can serve as a histopathological indicator for differentiation in gastrointestinal adenocarcinomas...
- Blood brain barrier immune compromise in NeuroAIDSGEORGETTE KANMOGNE; Fiscal Year: 2009..The work in this proposal will help us understand how HIV damages the brain endothelium and enters the brain, how to prevent viral entry into the brain, and HIV-associated dementia. ..
- NeuroAIDS in Cameroon: Molecular determinantsGEORGETTE KANMOGNE; Fiscal Year: 2007..It will provide knowledge on the epidemiology of neuroAIDS in Cameroon and build the capacity for future neuroAIDS research and therapeutic testing in Cameroon. ..
- HIV-1 gp120-induced Endothelial Cell DysfunctionGEORGETTE KANMOGNE; Fiscal Year: 2007....
- Blood brain barrier immune compromise in NeuroAIDSGeorgette D Kanmogne; Fiscal Year: 2010..The work in this proposal will help us understand how HIV damages the brain endothelium and enters the brain, how to prevent viral entry into the brain, and HIV-associated dementia. ..
- Leukocyte Migration in Wounded CorneaAlan Burns; Fiscal Year: 2007....
- Intestinal Epithelial Tight Junction Structure-FunctionAsma Nusrat; Fiscal Year: 2005....
- Intestinal Epithelial Tight Junction Structure-FunctionAsma Nusrat; Fiscal Year: 2007..Additionally, understanding the molecular composition of AJCs will also facilitate in designing molecules that can be delivered via the paracellular route. ..
- Estrogen and Aging effects on Transvaginal TransportGeorge Gorodeski; Fiscal Year: 2007....
- REGULATORY PATHWAYS AND ROLE OF VPF/VEGF IN RENAL CANCERDebabrata Mukhopadhyay; Fiscal Year: 2007....
- Distinct Pathways of VPF/VEGF ReceptorsDebabrata Mukhopadhyay; Fiscal Year: 2007..Hence, the results of these proposed studies will help identify potential angiogenic inhibitors or promoters that can be targeted and used to improve future therapies against different diseases. ..
- Intestinal Epithelial Tight Junction Structure-FunctionAsma Nusrat; Fiscal Year: 2010..Additionally, understanding the molecular composition of AJCs will also facilitate in designing molecules that can be delivered via the paracellular route. ..
- REGULATORY PATHWAYS AND ROLE OF VPF/VEGF IN RENAL CANCERDebabrata Mukhopadhyay; Fiscal Year: 2010....
- Targeting Pancreatic Cancer Using Peptide Chemistry: From Bench to BedsideMark R Spaller; Fiscal Year: 2010..The proposed study might define the mechanism of pancreatic cancer growth and progression and identify specific targets for therapeutic interventions for pancreatic adenocarcinoma where no current therapy is available. ..
- Enterovirus entry into polarized endothelial cellsCarolyn B Coyne; Fiscal Year: 2010..The studies in this proposal will identify cellular genes required for mediating enterovirus infection and may lead to the design of cell-type-specific antiviral targets. ..
- Distinct Pathways of VPF/VEGF ReceptorsDebabrata Mukhopadhyay; Fiscal Year: 2010..Hence, the results of these proposed studies will help identify potential angiogenic inhibitors or promoters that can be targeted and used to improve future therapies against different diseases. ..
- Intestinal Mucosal Wound Resealing in IBDAsma Nusrat; Fiscal Year: 2010....
- Intestinal Epithelial Tight Junction Structure-FunctionAsma Nusrat; Fiscal Year: 2009..Additionally, understanding the molecular composition of AJCs will also facilitate in designing molecules that can be delivered via the paracellular route. ..
- REGULATORY PATHWAYS AND ROLE OF VPF/VEGF IN RENAL CANCERDebabrata Mukhopadhyay; Fiscal Year: 2009....
- Intestinal Mucosal Wound Resealing in IBDAsma Nusrat; Fiscal Year: 2009....
- Role of Beta Subunit of Sodium Pump in Cell AdhesionAyyappan Rajasekaran; Fiscal Year: 2007..abstract_text> ..
- Intestinal Mucosal Wound ResealingAsma Nusrat; Fiscal Year: 2007..abstract_text> ..
- The Neurotransmitter dopamine and angiogenesisDebabrata Mukhopadhyay; Fiscal Year: 2007..abstract_text> ..
- MUCOSAL PROTECTIVE FACTORS IN HUMAN MILKRadhakrishna Rao; Fiscal Year: 2003..protective factors in breast milk, and provide the basis for further characterization of the mechanisms involved in mucosal protection by breast milk, and their role in preventing neonatal gastrointestinal diseases ..
- Neurotransmitter dopamine and angiogenesisDebabrata Mukhopadhyay; Fiscal Year: 2003..abstract_text> ..
- AGING EFFECTS ON TRANSVAGINAL TRANSPORTGeorge Gorodeski; Fiscal Year: 2002..These data may improve our understanding of estrogen replacement to postmenopausal women. They may also provide efficient and simple modalities for birth control by targeting known mechanisms of transcervical transport. ..
- The Neurotransmitter dopamine and angiogenesisDebabrata Mukhopadhyay; Fiscal Year: 2006..abstract_text> ..
- Distinct Pathways of VPF/VEGF ReceptorsDebabrata Mukhopadhyay; Fiscal Year: 2005..Taken together these experiments are likely to identify new therapeutic targets in order to combat angiogenesis in tumors and also in other disease processes. ..