OAT1

Summary

Gene Symbol: OAT1
Description: solute carrier family 22 member 6
Alias: HOAT1, OAT1, PAHT, ROAT1, solute carrier family 22 member 6, PAH transporter, hPAHT, hROAT1, organic anion transporter 1, para-aminohippurate transporter, renal organic anion transporter 1, solute carrier family 22 (organic anion transporter), member 6
Species: human
Products:     OAT1

Top Publications

  1. Wang M, Zhao J, Zhang N, Chen J. Astilbin improves potassium oxonate-induced hyperuricemia and kidney injury through regulating oxidative stress and inflammation response in mice. Biomed Pharmacother. 2016;83:975-988 pubmed publisher
    ..Glucose transporter 9 (GLUT9), Human urate transporter 1 (URAT1) expression and up-regulation of ABCG2, Organic anion transporter 1/3 (OAT1/3) and Organic cation transporter 1 (OCT1)...
  2. Wang S, Fang Y, Yu X, Guo L, Zhang X, Xia D. The flavonoid-rich fraction from rhizomes of Smilax glabra Roxb. ameliorates renal oxidative stress and inflammation in uric acid nephropathy rats through promoting uric acid excretion. Biomed Pharmacother. 2019;111:162-168 pubmed publisher
    ..uric acid excretion was related to its increase of ATP-binding cassette transporter G2 (ABCG2), organic anion transporter 1 (OAT1), organic anion transporters 2 (OCT2) and organic cation/carnitine transporters 2 (OCTN2) ..
  3. Eisner C, Faulhaber Walter R, Wang Y, Leelahavanichkul A, Yuen P, Mizel D, et al. Major contribution of tubular secretion to creatinine clearance in mice. Kidney Int. 2010;77:519-26 pubmed publisher
    ..Increasing plasma creatinine threefold by infusion further increased the secretion fraction. Renal organic anion transporter 1 mRNA expression was higher in male than in female mice, reflecting the gender difference in ..
  4. Yang Y, Zhang D, Liu J, Hu L, Xue Q, Ding X, et al. Wuling San protects kidney dysfunction by inhibiting renal TLR4/MyD88 signaling and NLRP3 inflammasome activation in high fructose-induced hyperuricemic mice. J Ethnopharmacol. 2015;169:49-59 pubmed publisher
    ..1 (URAT1), glucose transporter 9 (GLUT9), ATP-binding cassette subfamily G member 2 (ABCG2) and organic anion transporter 1 (OAT1), as well as organic cation transporter 1 (OCT1) and OCT2 in mice...
  5. Wang K, Hu L, Chen J. RIP3-deficience attenuates potassium oxonate-induced hyperuricemia and kidney injury. Biomed Pharmacother. 2018;101:617-626 pubmed publisher
    ..mice showed significantly high mRNA levels of ATP-binding cassette, subfamily G, membrane 2 (ABCG2), organic anion transporter 1 (OAT1), OAT3, organic cation transporter 1 (OCT1) and organic cation/carnitine transporter 1 (OCTN1) in ..
  6. Liang D, Yong T, Chen S, Xie Y, Chen D, Zhou X, et al. Hypouricemic Effect of 2,5-Dihydroxyacetophenone, a Computational Screened Bioactive Compound from Ganoderma applanatum, on Hyperuricemic Mice. Int J Mol Sci. 2018;19: pubmed publisher
    ..transcription PCR (RT-PCR) and Western blot were exploited to assay RNA and protein expressions of organic anion transporter 1 (OAT1), glucose transporter 9 (GLUT9), uric acid transporter 1 (URAT1), and gastrointestinal ..
  7. Qian X, Wang X, Luo J, Liu Y, Pang J, Zhang H, et al. Hypouricemic and nephroprotective roles of anthocyanins in hyperuricemic mice. Food Funct. 2019;10:867-878 pubmed publisher
    ..TNF-α) and interleukin-1β (IL-1β) and regulated the expression of renal urate transporters URAT1, GLUT9, ABCG2, OAT1, OAT3, OCT1, OCT2, OCTN1 and OCTN2...
  8. Miner J, Tan P, Hyndman D, Liu S, Iverson C, Nanavati P, et al. Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney. Arthritis Res Ther. 2016;18:214 pubmed
    ..Unlike probenecid, lesinurad did not inhibit OAT1 or OAT3 in the clinical setting...
  9. Niwa T. The role of carbon adsorbent in the conservative management of chronic kidney disease. Panminerva Med. 2017;59:139-148 pubmed publisher
    ..phosphate oxidase, and by activating aryl hydrocarbon receptor through its uptake via organic anion transporters (OAT1 and OAT3)...

More Information

Publications134 found, 100 shown here

  1. Honscha W, Dötsch K, Thomsen N, Petzinger E. Cloning and functional characterization of the bile acid-sensitive methotrexate carrier from rat liver cells. Hepatology. 2000;31:1296-304 pubmed
    ..carriers, but no homology is found to the transport systems for organic anions like the Ntcp1, oatp1, OAT-K1, and OAT1. Expression of the mRNA for the methotrexate carrier is found in liver, kidney, heart, brain, spleen, lung, and ..
  2. Mihaljević I, Popovic M, Zaja R, Smital T. Phylogenetic, syntenic, and tissue expression analysis of slc22 genes in zebrafish (Danio rerio). BMC Genomics. 2016;17:626 pubmed publisher
    ..Dominant genes in brain were oat1 in females and oct1 in males, while the highest gender differences were determined in gonads, with dominant ..
  3. Kazmi F, Yerino P, McCoy C, Parkinson A, Buckley D, Ogilvie B. An Assessment of the In Vitro Inhibition of Cytochrome P450 Enzymes, UDP-Glucuronosyltransferases, and Transporters by Phosphodiester- or Phosphorothioate-Linked Oligonucleotides. Drug Metab Dispos. 2018;46:1066-1074 pubmed publisher
    ..transporters, including organic anion-transporting polypeptide OATP1B1 and OATP1B3, organic anion transporters OAT1 and OAT3, and organic cation transporter OCT2 (IC50 values of 12-29 μM), but not OCT1 or the ..
  4. Mamidi R, Dallas S, Sensenhauser C, Lim H, Scheers E, Verboven P, et al. In vitro and physiologically-based pharmacokinetic based assessment of drug-drug interaction potential of canagliflozin. Br J Clin Pharmacol. 2017;83:1082-1096 pubmed publisher
    ..of uptake transporters (organic anion transporter polypeptide isoforms OATP1B1, OATP1B3, organic anion transporters OAT1 and OAT3, and organic cationic transporters OCT1, and OCT2)...
  5. Lash L, Lee C, Wilker C, Shah V. Transporter-dependent cytotoxicity of antiviral drugs in primary cultures of human proximal tubular cells. Toxicology. 2018;404-405:10-24 pubmed publisher
    ..The function of relevant membrane transporters, organic anion transporter 1 and 3 (OAT1/3), P-glycoprotein (multidrug resistance protein-1; P-gp or MDR1), and organic cation ..
  6. Chen G, Tan M, Li K, Leung P, Ko C. Green tea polyphenols decreases uric acid level through xanthine oxidase and renal urate transporters in hyperuricemic mice. J Ethnopharmacol. 2015;175:14-20 pubmed publisher
    ..300 and 600 mg/kg GTP clearly reduced XOD expression in liver, as well as reduced URAT1 expression and increased OAT1 and OAT3 expressions in kidney of hyperuricemic mice (p<0.05 or p<0.01)...
  7. Brauburger K, Burckhardt G, Burckhardt B. The sodium-dependent di- and tricarboxylate transporter, NaCT, is not responsible for the uptake of D-, L-2-hydroxyglutarate and 3-hydroxyglutarate into neurons. J Inherit Metab Dis. 2011;34:477-82 pubmed publisher
    ..We have recently shown that these compounds are eliminated by the kidneys via the human organic anion transporters, OAT1 and OAT4, and the sodium-dependent dicarboxylate transporter 3, NaDC3...
  8. Savira F, Cao L, Wang I, Yang W, Huang K, Hua Y, et al. Apoptosis signal-regulating kinase 1 inhibition attenuates cardiac hypertrophy and cardiorenal fibrosis induced by uremic toxins: Implications for cardiorenal syndrome. PLoS ONE. 2017;12:e0187459 pubmed publisher
    ..ASK1, OAT1/3, ERK1/2 and p38MAPK inhibitors suppressed all these effects...
  9. Guo Y, Jiang Q, Gui D, Wang N. Chinese Herbal Formulas Si-Wu-Tang and Er-Miao-San Synergistically Ameliorated Hyperuricemia and Renal Impairment in Rats Induced by Adenine and Potassium Oxonate. Cell Physiol Biochem. 2015;37:1491-502 pubmed publisher
    ..The renal expression of organic anion transporter 1 (OAT1) and organic anion transporter 3 (OAT3) was detected by western blot...
  10. Jhang J, Ong J, Lu C, Hsu C, Lin J, Liao J, et al. Hypouricemic effects of Mesona procumbens Hemsl. through modulating xanthine oxidase activity in vitro and in vivo. Food Funct. 2016;7:4239-4246 pubmed
    ..EE50 down-regulated STZ-induced liver XO activity, and it restored renal OAT1 and urate transporter expression...
  11. Jiang Y, Lin Y, Hu Y, Song X, Pan H, Zhang H. Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model. BMC Complement Altern Med. 2017;17:320 pubmed publisher
    ..showed activity in reducing serum uric acid (Sur) through effect renal glucose transporter 9 (GLUT9), organic anion transporter 1 (OAT1) and urate transporter 1 (URAT1) mainly and inhibited XO activity in vivo of mice with PO induced ..
  12. Dragojević J, Mihaljević I, Popovic M, Zaja R, Smital T. In vitro characterization of zebrafish (Danio rerio) organic anion transporters Oat2a-e. Toxicol In Vitro. 2018;46:246-256 pubmed publisher
    ..Zebrafish (Danio rerio) has seven OAT orthologs: Oat1, Oat2a-e and Oat3. In this study we specifically address Oat2 (Slc22a7) family...
  13. Chen Y, Chen C, Yan W, Ge H, Kong L. Anti-hyperuricemic and anti-inflammatory actions of vaticaffinol isolated from Dipterocarpus alatus in hyperuricemic mice. Chin J Nat Med. 2017;15:330-340 pubmed publisher
    ..regulated renal mRNA and protein levels of urate transporter 1 (URAT1), glucose transporter 9 (GLUT9), organic anion transporter 1 (OAT1), organic cation transporter 1 (OCT1), OCT2, organic cation/carnitine transporter 1 (OCTN1), and ..
  14. Qi X, Zhu L, Yang B, Luo H, Xu W, He X, et al. Mitigation of cell apoptosis induced by ochratoxin A (OTA) is possibly through organic cation transport 2 (OCT2) knockout. Food Chem Toxicol. 2018;121:15-23 pubmed publisher
    ..OCT2 knockout did not change the gene expression of OCT1, OAT1 and OAT3...
  15. Lofthouse E, Cleal J, O Kelly I, Sengers B, Lewis R. Estrone sulphate uptake by the microvillous membrane of placental syncytiotrophoblast is coupled to glutamate efflux. Biochem Biophys Res Commun. 2018;506:237-242 pubmed publisher
    ..No glutamate transport was observed in oocytes expressing OAT1, OAT3, OAT7 or OATP2A1...
  16. Yao H, Xu Y, Yin L, Tao X, Xu L, Qi Y, et al. Dioscin Protects ANIT-Induced Intrahepatic Cholestasis Through Regulating Transporters, Apoptosis and Oxidative Stress. Front Pharmacol. 2017;8:116 pubmed publisher
    ..In mechanism study, dioscin not only significantly regulated the protein levels of Ntcp, OAT1, OCT1, Bsep and Mrp2 to accelerate bile acids excretion, but also regulated the expression levels of Bak, Bcl-xl, ..
  17. Morimoto K, Nagaoka K, Nagai A, Kashii H, Hosokawa M, Takahashi Y, et al. Analysis of a child who developed abnormal neuropsychiatric symptoms after administration of oseltamivir: a case report. BMC Neurol. 2015;15:130 pubmed publisher
    ..analysis and glutamate receptor autoantibodies), drug level determination and simulation, and genetic assessment (OAT1, OAT3, CES1, Neu2)...
  18. Tsuruya Y, Nakanishi T, Komori H, Wang X, Ishiguro N, Kito T, et al. Different Involvement of OAT in Renal Disposition of Oral Anticoagulants Rivaroxaban, Dabigatran, and Apixaban. J Pharm Sci. 2017;106:2524-2534 pubmed publisher
    ..interactions of 3 anticoagulants, rivaroxaban, apixaban, and dabigatran, with 5 human solute carrier transporters, hOAT1, hOAT3, hOCT2, hOATP1B1, and hOATP1B3...
  19. Zhu L, Dong Y, Na S, Han R, Wei C, Chen G. Saponins extracted from Dioscorea collettii rhizomes regulate the expression of urate transporters in chronic hyperuricemia rats. Biomed Pharmacother. 2017;93:88-94 pubmed publisher
    ..Further, the model groups showed significantly lower expression of organic anion transporter 1 (OAT1) and organic anion transporter 3 (OAT3) and significantly higher expression of renal tubular ..
  20. Wang M, Liu Y, Yang Y, Zhang D, Kong L. Nuciferine restores potassium oxonate-induced hyperuricemia and kidney inflammation in mice. Eur J Pharmacol. 2015;747:59-70 pubmed publisher
    ..1 (URAT1), glucose transporter 9 (GLUT9), ATP-binding cassette, subfamily G, membrane 2 (ABCG2), organic anion transporter 1 (OAT1), organic cation transporter 1 (OCT1), and organic cation/carnitine transporters 1/2 (OCTN1/2) in ..
  21. Ulu R, Dogukan A, Tuzcu M, Gencoglu H, Ulas M, Ilhan N, et al. Regulation of renal organic anion and cation transporters by thymoquinone in cisplatin induced kidney injury. Food Chem Toxicol. 2012;50:1675-9 pubmed publisher
    ..the induced renal injury increased protein levels of the efflux transporters MRP2 and MRP4 while expression of OAT1, OAT3, OCT1 and OCT2 was reduced...
  22. De Zwart L, Scholten M, Monbaliu J, Annaert P, Van Houdt J, van den Wyngaert I, et al. The ontogeny of drug metabolizing enzymes and transporters in the rat. Reprod Toxicol. 2008;26:220-30 pubmed publisher
    ..activity in liver microsomes, and mRNA expression of transporters (Mdr1a/b, Mrp1-3 and 6, Bsep and Bcrp, Oct1-2, Oat1-3 and Oatp1a4) in liver, kidney and brain tissue during development in Sprague-Dawley rats...
  23. Bleasby K, Fillgrove K, Houle R, Lu B, Palamanda J, Newton D, et al. In Vitro Evaluation of the Drug Interaction Potential of Doravirine. Antimicrob Agents Chemother. 2019;63: pubmed publisher
    ..with substrates of BCRP, P-glycoprotein, OATP1B1 and OATP1B3, the bile salt extrusion pump (BSEP), organic anion transporter 1 (OAT1) and OAT3, organic cation transporter 2 (OCT2), and multidrug and toxin extrusion 1 (MATE1) and ..
  24. Shemesh C, Yu R, Warren M, Liu M, Jahic M, Nichols B, et al. Assessment of the Drug Interaction Potential of Unconjugated and GalNAc3-Conjugated 2'-MOE-ASOs. Mol Ther Nucleic Acids. 2017;9:34-47 pubmed publisher
    ..organic anion transporting polypeptide 1B1 (OATP1B1), and OATP1B3; three renal uptake transporters, organic anion transporter 1 (OAT1), OAT3, and OCT2; and three efflux transporters, P-glycoprotein (P-gp), breast cancer resistance ..
  25. Wen S, Wang C, Huo X, Meng Q, Liu Z, Yang S, et al. JBP485 attenuates vancomycin-induced nephrotoxicity by regulating the expressions of organic anion transporter (Oat) 1, Oat3, organic cation transporter 2 (Oct2), multidrug resistance-associated protein 2 (Mrp2) and P-glycoprotein (P-gp) in rats. Toxicol Lett. 2018;295:195-204 pubmed publisher
    ..Vancomycin suppressed the mRNA and protein expressions of Oat1, Oat3, Oct2, Mrp2 and P-gp to reduce the renal excretion of endogenous toxins (e.g. indoxyl sulfate)...
  26. Wei L, Tominaga H, Ohgaki R, Wiriyasermkul P, Hagiwara K, Okuda S, et al. Transport of 3-fluoro-L-α-methyl-tyrosine (FAMT) by organic ion transporters explains renal background in [(18)F]FAMT positron emission tomography. J Pharmacol Sci. 2016;130:101-9 pubmed publisher
    ..We have found that OAT1, OAT10 and OCTN2 transport [(14)C]FAMT...
  27. Kosa R, Lazzaro S, Bi Y, Tierney B, Gates D, Modi S, et al. Simultaneous Assessment of Transporter-Mediated Drug-Drug Interactions Using a Probe Drug Cocktail in Cynomolgus Monkey. Drug Metab Dispos. 2018;46:1179-1189 pubmed publisher
    ..An OAT1/3 inhibitor (probenecid) significantly (P < 0...
  28. Yong T, Li D, Li M, Liang D, Diao X, Deng C, et al. Anti-Hyperuricemic Effect of 2-Hydroxy-4-methoxy-benzophenone-5-sulfonic Acid in Hyperuricemic Mice through XOD. Molecules. 2018;23: pubmed publisher
    ..Its anti-hyperuricemic mechanisms may be ascribed to its inhibition of XOD and its up-regulation of organic anion transporter 1 (OAT1) and down-regulation of glucose transporter 9 (GLUT9).
  29. Babelova A, Burckhardt B, Wegner W, Burckhardt G, Henjakovic M. Sex-differences in renal expression of selected transporters and transcription factors in lean and obese Zucker spontaneously hypertensive fatty rats. J Diabetes Res. 2015;2015:483238 pubmed publisher
    ..Real-time PCR on RNA isolated from kidney cortex revealed that Sglt1-2, Oat1-3, and Oct1 were higher expressed in kidneys of lean females. Oct2 and Mrp2 were higher expressed in obese males...
  30. Erman F, Tuzcu M, Orhan C, Sahin N, Sahin K. Effect of lycopene against cisplatin-induced acute renal injury in rats: organic anion and cation transporters evaluation. Biol Trace Elem Res. 2014;158:90-5 pubmed publisher
    ..1.37 mg/dl) levels and the kidney efflux transporters MRP2 and MRP4 levels were significantly increased, whereas OAT1, OAT3, OCT1, and OCT2 levels in kidney were decreased in the treated rats compared with normal control rats...
  31. Xu L, Shi Y, Zhuang S, Liu N. Recent advances on uric acid transporters. Oncotarget. 2017;8:100852-100862 pubmed publisher
    ..organic anion transporter 4 (OAT4) and glucose transporter 9 (GLUT9), and urate excretion transporetrs, including OAT1, OAT3, urate transporter (UAT), multidrug resistance protein 4 (MRP4/ABCC4), ABCG-2 and sodium-dependent phosphate ..
  32. Tong Z, Yerramilli U, Surapaneni S, Kumar G. The interactions of lenalidomide with human uptake and efflux transporters and UDP-glucuronosyltransferase 1A1: lack of potential for drug-drug interactions. Cancer Chemother Pharmacol. 2014;73:869-74 pubmed publisher
    ..cancer resistance protein (BCRP), multidrug resistance proteins (MRP1, MRP2, MRP3), organic anion transporters (OAT1, OAT3), organic cation transporters (OCT1 and OCT2), human organic cation transporter novel 1 and 2 (OCTN1 and ..
  33. Yong T, Chen S, Xie Y, Shuai O, Li X, Chen D, et al. Hypouricemic Effects of Extracts From Agrocybe aegerita on Hyperuricemia Mice and Virtual Prediction of Bioactives by Molecular Docking. Front Pharmacol. 2018;9:498 pubmed publisher
    ..suppression effects on hepatic xanthine oxidase (XOD) activities and elevation effects on renal OAT1 (organic anion transporter 1). However, only little negative impact was observed on the inner organ functions...
  34. Zhang Q, Zhang Y, Boer J, Shi J, Hu P, Diamond S, et al. In Vitro Interactions of Epacadostat and its Major Metabolites with Human Efflux and Uptake Transporters: Implications for Pharmacokinetics and Drug Interactions. Drug Metab Dispos. 2017;45:612-623 pubmed publisher
    ..of EPAC, M9, M11, and M12 to cause clinical drug-drug interactions via inhibition of P-gp, BCRP, OATP1B1, OATP1B3, OAT1, OAT3, or organic cation transporter 2 was estimated to be low...
  35. Shen Z, Yeh L, Wallach K, Zhu N, Kerr B, Gillen M. In Vitro and In Vivo Interaction Studies Between Lesinurad, a Selective Urate Reabsorption Inhibitor, and Major Liver or Kidney Transporters. Clin Drug Investig. 2016;36:443-52 pubmed publisher
    ..Lesinurad interacted in vitro with OATP1B1, OCT1, and OAT1/3 transporters...
  36. Wei Z, He J, Fu W, Zhang Z. Osteomalacia induced by long-term low-dose adefovir dipivoxil: Clinical characteristics and genetic predictors. Bone. 2016;93:97-103 pubmed publisher
    ..The G/A genotype at c.2934 of the ABCC2 gene may be a predictor of patients at greater risk for developing ADV-associated tubulopathy. Larger case-control studies are needed to further verify this finding. ..
  37. Chedik L, Bruyère A, Le Vee M, Stieger B, Denizot C, Parmentier Y, et al. Inhibition of Human Drug Transporter Activities by the Pyrethroid Pesticides Allethrin and Tetramethrin. PLoS ONE. 2017;12:e0169480 pubmed publisher
    ..By contrast, allethrin and tetramethrin cis-stimulated OATP2B1 activity and failed to alter activities of OATP1B3, OAT1 and MATE2-K, whereas P-glycoprotein activity was additionally moderately inhibited...
  38. Feng Z, Xiang Lei L, Hai Tao W, Zuo Pei W, Bao Li H, Hai Feng Z, et al. Programmed cell death 1 expression in esophageal squamous cell carcinoma and association with clinical characteristics. Indian J Cancer. 2015;52 Suppl 3:E176-8 pubmed publisher
    ..The PD-1 positive rate was 51.2% (45/88), 22.9% (8/35), and 6.7% (2/30) for the cancer tissue, PAHT, and RNET, respectively, with statistical difference (P < 0...
  39. Nigam S. The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease. Annu Rev Pharmacol Toxicol. 2018;58:663-687 pubmed publisher
    ..Some-including OAT1 [SLC22A6 or NKT (novel kidney transporter)] and OAT3 (SLC22A8), as well as OCT1 (SLC22A1) and OCT2 (SLC22A2)-are ..
  40. Brandoni A, Torres A. Altered Renal Expression of Relevant Clinical Drug Transporters in Different Models of Acute Uremia in Rats. Role of Urea Levels. Cell Physiol Biochem. 2015;36:907-16 pubmed publisher
    b>Organic anion transporter 1 (Oat1) and 3 (Oat3) are organic anion transporters that play critical roles in the body disposition of numerous clinically important drugs...
  41. Ball K, Jamier T, Parmentier Y, Denizot C, Mallier A, Chenel M. Prediction of renal transporter-mediated drug-drug interactions for a drug which is an OAT substrate and inhibitor using PBPK modelling. Eur J Pharm Sci. 2017;106:122-132 pubmed publisher
    ..organic anion transporter (OAT) mediated drug-drug interactions involving S44121, a substrate and an inhibitor of OAT1 and OAT3...
  42. Mizuno N, Takahashi T, Kusuhara H, Schuetz J, Niwa T, Sugiyama Y. Evaluation of the role of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated protein 4 (MRP4/ABCC4) in the urinary excretion of sulfate and glucuronide metabolites of edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-. Drug Metab Dispos. 2007;35:2045-52 pubmed
    ..01 versus 5.06 ml/min/kg BW). Our results suggest that Bcrp and Mrp4 are partly involved in the luminal efflux of edaravone sulfate and edaravone glucuronide, respectively...
  43. Jia Y, Liu Z, Wang C, Meng Q, Huo X, Liu Q, et al. P-gp, MRP2 and OAT1/OAT3 mediate the drug-drug interaction between resveratrol and methotrexate. Toxicol Appl Pharmacol. 2016;306:27-35 pubmed publisher
    ..Similarly, MTX uptake was markedly inhibited by Res in rat kidney slices and hOAT1/3-HEK293 cell, indicating that OAT1 and OAT3 were involved in the drug interaction in the kidney...
  44. Worley R, Fisher J. Application of physiologically-based pharmacokinetic modeling to explore the role of kidney transporters in renal reabsorption of perfluorooctanoic acid in the rat. Toxicol Appl Pharmacol. 2015;289:428-41 pubmed publisher
    ..We developed a PBPK model for PFOA in male and female rats to explore the role of Oat1, Oat3, and Oatp1a1 in sex-specific renal reabsorption and excretion of PFOA...
  45. Zhang Y, Han Y, Putluru S, Matta M, Kole P, Mandlekar S, et al. Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro. Drug Metab Dispos. 2016;44:320-8 pubmed publisher
    ..In contrast, DF-AG was identified as a substrate of numerous OATs (Km = 8.6, 60.2, 103.9, and 112 µM for OAT2, OAT1, OAT4, and OAT3, respectively), two organic anion-transporting polypeptides (OATP1B1, Km = 34 µM; OATP2B1, Km = ..
  46. Zhang B, Li W, Hou W, Luo Y, Shi J, Li C, et al. Zuotai and HgS differ from HgCl2 and methyl mercury in Hg accumulation and toxicity in weanling and aged rats. Toxicol Appl Pharmacol. 2017;331:76-84 pubmed publisher
    ..The expression of renal uptake transporters Oat1, Oct2, and Oatp4c1 and hepatic Oatp2 was decreased, while the expression of renal efflux transporter Mrp2, Mrp4 and ..
  47. Henjakovic M, Hagos Y, Krick W, Burckhardt G, Burckhardt B. Human organic anion transporter 2 is distinct from organic anion transporters 1 and 3 with respect to transport function. Am J Physiol Renal Physiol. 2015;309:F843-51 pubmed publisher
    ..Experiments with human embryonic kidney-293 cells stably transfected with human OAT1, OAT2, or OAT3 were performed to compare selected transport properties...
  48. Zhu C, Nigam K, Date R, Bush K, Springer S, Saier M, et al. Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs. PLoS ONE. 2015;10:e0140569 pubmed publisher
    ..Disease-causing mutations, single nucleotide polymorphisms (SNPs) and other functionally analyzed mutations in OAT1, OAT3, URAT1, OCT1, OCT2, OCTN1, and OCTN2 map to the first extracellular domain, the large central intracellular ..
  49. Breljak D, Ljubojevic M, Hagos Y, Micek V, Balen Eror D, Vrhovac Madunić I, et al. Distribution of organic anion transporters NaDC3 and OAT1-3 along the human nephron. Am J Physiol Renal Physiol. 2016;311:F227-38 pubmed publisher
    ..secondary active Na(+)-dicarboxylate cotransporter 3 (NaDC3/SLC13A3), and tertiary active OA transporters (OATs) OAT1/SLC22A6, OAT2/SLC22A7, and OAT3/SLC22A8...
  50. Wang R, Ma C, Zhou F, Kong L. Siwu decoction attenuates oxonate-induced hyperuricemia and kidney inflammation in mice. Chin J Nat Med. 2016;14:499-507 pubmed publisher
    ..of hepatic XOD and renal urate transporter 1 (URAT1), glucose transporter 9 (GLUT9), organic anion transporters 1 (OAT1), ATP-binding cassette subfamily G member 2 (ABCG2), organic cation transporter 1 (OCT1), OCT2, organic cation/..
  51. Sager G, Smaglyukova N, Fuskevaag O. The role of OAT2 (SLC22A7) in the cyclic nucleotide biokinetics of human erythrocytes. J Cell Physiol. 2017;: pubmed publisher
    ..Western blotting showed that hRBC expressed OAT2 (SLC22A7), but detection of OAT1 (SLC22A6) or OAT3 (SLC22A8) was not possible...
  52. Zalups R, Aslamkhan A, Ahmad S. Human organic anion transporter 1 mediates cellular uptake of cysteine-S conjugates of inorganic mercury. Kidney Int. 2004;66:251-61 pubmed
    ..Using a line of Madin-Darby canine kidney (MDCK) II cells transfected stably with the human organic anion transporter 1 (hOAT1), and oocytes from Xenopus laevis microinjected with cRNA for hOAT1, we tested the hypothesis ..
  53. Mizuno N, Takahashi T, Iwase Y, Kusuhara H, Niwa T, Sugiyama Y. Human organic anion transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate. Drug Metab Dispos. 2007;35:1429-34 pubmed
    ..We examined the transport of edaravone and its sulfate and glucuronide conjugates via human organic anion transporter 1 (hOAT1) and 3 (hOAT3), expressed on the basolateral membranes of proximal tubules...
  54. Fan J, Ionita Laza I, McQueen M, Devlin B, Purcell S, Faraone S, et al. Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:29-37 pubmed publisher
    ..Further studies in larger samples are warranted to clarify which, if any, genes in the 6q region confer risk for bipolar disorder. ..
  55. Martovetsky G, Bush K, Nigam S. Kidney versus Liver Specification of SLC and ABC Drug Transporters, Tight Junction Molecules, and Biomarkers. Drug Metab Dispos. 2016;44:1050-60 pubmed publisher
    ..g., Slc22a6/Oat1, Slc47a1/Mate1, Slc22a12/Urat1, Abcg2/Bcrp, Abcc2/Mrp2, Abcc4/Mrp4), nutrient transporters (e.g...
  56. Hong M, Li S, Zhou F, Thomas P, You G. Putative transmembrane domain 12 of the human organic anion transporter hOAT1 determines transporter stability and maturation efficiency. J Pharmacol Exp Ther. 2010;332:650-8 pubmed publisher
    Human organic anion transporter hOAT1 plays a critical role in the body disposition of clinically important drugs...
  57. Yee S, Giacomini M, Hsueh C, Weitz D, Liang X, Goswami S, et al. Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1. Clin Pharmacol Ther. 2016;100:524-536 pubmed publisher
    ..studies confirmed tetradecanedioate (TDA) and hexadecanedioate (HDA) were novel substrates of OATP1B1 as well as OAT1 and OAT3...
  58. Yong T, Chen S, Xie Y, Chen D, Su J, Shuai O, et al. Hypouricemic Effects of Ganoderma applanatum in Hyperuricemia Mice through OAT1 and GLUT9. Front Pharmacol. 2017;8:996 pubmed publisher
    ..Almost no suppressing effect was observed on the XOD activities. However, compared to the hyperuricemia control, OAT1 was elevated remarkably in mice drugged with GAE and GAW, while GLUT9 was significantly decreased...
  59. Nieskens T, Peters J, Dabaghie D, Korte D, Jansen K, van Asbeck A, et al. Expression of Organic Anion Transporter 1 or 3 in Human Kidney Proximal Tubule Cells Reduces Cisplatin Sensitivity. Drug Metab Dispos. 2018;46:592-599 pubmed publisher
    ..epithelial cells (ciPTEC) expressing renal drug transporters, including OCT2 and organic anion transporters 1 (OAT1) or 3 (OAT3)...
  60. Feng Y, Wang C, Liu Q, Meng Q, Huo X, Liu Z, et al. Bezafibrate-mizoribine interaction: Involvement of organic anion transporters OAT1 and OAT3 in rats. Eur J Pharm Sci. 2016;81:119-28 pubmed publisher
    ..The uptakes of bezafibrate and mizoribine in highest concentration were increased 1.63 and 1.46 folds in hOAT1-transfected cells, 1.43 and 1.24 folds in hOAT3-transfected cells, respectively...
  61. Mathialagan S, Piotrowski M, Tess D, Feng B, Litchfield J, Varma M. Quantitative Prediction of Human Renal Clearance and Drug-Drug Interactions of Organic Anion Transporter Substrates Using In Vitro Transport Data: A Relative Activity Factor Approach. Drug Metab Dispos. 2017;45:409-417 pubmed publisher
    ..Selective substrates to OAT1 (tenofovir), OAT2 (acyclovir and ganciclovir), and OAT3 (benzylpenicillin, oseltamivir acid) were used to obtain ..
  62. Yuan Y, Yang H, Kong L, Li Y, Li P, Zhang H, et al. Interaction between rhein acyl glucuronide and methotrexate based on human organic anion transporters. Chem Biol Interact. 2017;277:79-84 pubmed publisher
    ..metabolite of rhein in the human blood circulation, significantly inhibited the uptake of p-aminohippurate in hOAT1 transfected cells with IC50 value of 691 nM and estrone sulfate uptake in hOAT3 transfected cells with ..
  63. Pavlova A, Sakurai H, Leclercq B, Beier D, Yu A, Nigam S. Developmentally regulated expression of organic ion transporters NKT (OAT1), OCT1, NLT (OAT2), and Roct. Am J Physiol Renal Physiol. 2000;278:F635-43 pubmed
    ..When we initially identified NKT, also known as OAT1, the first member of the organic anion transporter (OAT) family (Lopez-Nieto CE, You G, Bush KT, Barros EJ, Beier ..
  64. Hong M, Zhou F, You G. Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1. J Biol Chem. 2004;279:31478-82 pubmed
    Human organic anion transporter 1 (hOAT1) belongs to a superfamily of organic anion transporters, which play critical roles in the body disposition of clinically important drugs, including anti-human immunodeficiency virus therapeutics, ..
  65. Torres A. Renal elimination of organic anions in cholestasis. World J Gastroenterol. 2008;14:6616-21 pubmed
    The disposition of most drugs is highly dependent on specialized transporters. OAT1 and OAT3 are two organic anion transporters expressed in the basolateral membrane of renal proximal tubule cells, identified as contributors to xenobiotic ..
  66. Vallon V, Eraly S, Rao S, Gerasimova M, Rose M, Nagle M, et al. A role for the organic anion transporter OAT3 in renal creatinine secretion in mice. Am J Physiol Renal Physiol. 2012;302:F1293-9 pubmed publisher
    ..The organic anion transporters, OAT1 and OAT3, are expressed on the basolateral membrane of the proximal tubule and transport organic anions but also ..
  67. Yin J, Duan H, Shirasaka Y, Prasad B, Wang J. Atenolol Renal Secretion Is Mediated by Human Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Proteins. Drug Metab Dispos. 2015;43:1872-81 pubmed publisher
    ..However, it is transported by hOCT1, hOCT2, hMATE1, and hMATE2-K, but not by hOCT3, hOAT1, and hOAT3...
  68. Wen S, Wang C, Duan Y, Huo X, Meng Q, Liu Z, et al. OAT1 and OAT3 also mediate the drug-drug interaction between piperacillin and tazobactam. Int J Pharm. 2018;537:172-182 pubmed publisher
    ..Moreover, the uptakes of piperacillin, tazobactam and sulbactam in hOAT1/3-HEK293 cells were significantly higher compared with mock-HEK293 cells, respectively...
  69. Motohashi H, Nakao Y, Masuda S, Katsura T, Kamba T, Ogawa O, et al. Precise comparison of protein localization among OCT, OAT, and MATE in human kidney. J Pharm Sci. 2013;102:3302-8 pubmed publisher
    ..In this study, the expression and distribution of apical MATE1 and MATE2-K, and basolateral OAT1, OAT3, and OCT2 were compared using serial sections of human kidney cortex...
  70. Xu D, Wang H, Zhang Q, You G. Nedd4-2 but not Nedd4-1 is critical for protein kinase C-regulated ubiquitination, expression, and transport activity of human organic anion transporter 1. Am J Physiol Renal Physiol. 2016;310:F821-31 pubmed publisher
    Human organic anion transporter 1 (hOAT1) expressed at the membrane of the kidney proximal tubule cells mediates the body disposition of a diverse array of clinically important drugs, including anti-HIV therapeutics, antitumor drugs, ..
  71. Toh e A, Ohkusu M, Shimizu K, Takahashi Nakaguchi A, Kawamoto S, Ishiwada N, et al. Putative orotate transporter of Cryptococcus neoformans, Oat1, is a member of the NCS1/PRT transporter super family and its loss causes attenuation of virulence. Curr Genet. 2017;63:697-707 pubmed publisher
    ..in utilization of orotic acid, most probably as transporter, we designated this gene Orotic Acid Transporter 1 (OAT1). This is the first report of orotic acid transporter in this family. C...
  72. Zalups R, Ahmad S. Homocysteine and the renal epithelial transport and toxicity of inorganic mercury: role of basolateral transporter organic anion transporter 1. J Am Soc Nephrol. 2004;15:2023-31 pubmed
    ..With the use of a line of type II MDCK cells transfected stably with the human organic anion transporter 1 (hOAT1), the hypothesis that hOAT1 can transport mercuric conjugates of homocysteine (Hcy) was tested...
  73. Bleasby K, Hall L, Perry J, Mohrenweiser H, Pritchard J. Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6). J Pharmacol Exp Ther. 2005;314:923-31 pubmed
    The human organic anion transporter hOAT1 (SLC22A6) contributes to the uptake of a range of small organic anions across the basolateral membrane of the renal proximal tubule and drives their urinary elimination...
  74. Windass A, Lowes S, Wang Y, Brown C. The contribution of organic anion transporters OAT1 and OAT3 to the renal uptake of rosuvastatin. J Pharmacol Exp Ther. 2007;322:1221-7 pubmed
    ..4 microM). In contrast hOAT1 did not mediate rosuvastatin uptake...
  75. Perry J, Dembla Rajpal N, Hall L, Pritchard J. A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport. J Biol Chem. 2006;281:38071-9 pubmed
    ..In this investigation, a theoretical three-dimensional model was generated for human OAT1 (hOAT1) based on fold recognition to the crystal structure of the glycerol 3-phosphate transporter (GlpT) from ..
  76. Jenkinson S, Chung G, van Loon E, Bakar N, Dalzell A, Brown C. The limitations of renal epithelial cell line HK-2 as a model of drug transporter expression and function in the proximal tubule. Pflugers Arch. 2012;464:601-11 pubmed publisher
    ..qPCR showed no mRNA expression of the SLC22 transporter family (OAT1, OAT3, OCT2) in HK-2 cells compared to renal cortex samples...
  77. Wu W, Bush K, Nigam S. Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes. Sci Rep. 2017;7:4939 pubmed publisher
    ..kynurenine, creatinine, urate) include two "drug" transporters of the organic anion transporter (OAT) family: OAT1 (SLC22A6, originally NKT) and OAT3 (SLC22A8)...
  78. Bush K, Wu W, Lun C, Nigam S. The drug transporter OAT3 (SLC22A8) and endogenous metabolite communication via the gut-liver-kidney axis. J Biol Chem. 2017;292:15789-15803 pubmed publisher
    The organic anion transporters OAT1 (SLC22A6) and OAT3 (SLC22A8) have similar substrate specificity for drugs, but it is far from clear whether this holds for endogenous substrates...
  79. Uwai Y, Honjo E. Transport of xanthurenic acid by rat/human organic anion transporters OAT1 and OAT3. Biosci Biotechnol Biochem. 2013;77:1517-21 pubmed
    ..Our laboratory previously described its transport by rat/human organic anion transporters rOAT1, hOAT1, rOAT3 and hOAT3, which are involved in drug disposition...
  80. Stopfer P, Giessmann T, Hohl K, Sharma A, Ishiguro N, Taub M, et al. Pharmacokinetic Evaluation of a Drug Transporter Cocktail Consisting of Digoxin, Furosemide, Metformin, and Rosuvastatin. Clin Pharmacol Ther. 2016;100:259-67 pubmed publisher
    ..Single oral doses of 0.25 mg digoxin (P-gp), 5 mg furosemide (OAT1 and OAT3), 500 mg metformin (OCT2, MATE1, and MATE2-K), and 10 mg rosuvastatin (OATP1B1, OATP1B3, and BCRP) were ..
  81. Liu H, Goldenberg A, Chen Y, Lun C, Wu W, Bush K, et al. Molecular Properties of Drugs Interacting with SLC22 Transporters OAT1, OAT3, OCT1, and OCT2: A Machine-Learning Approach. J Pharmacol Exp Ther. 2016;359:215-29 pubmed publisher
    ..e., SLC22A6 or OAT1, SLC22A8 or OAT3, SLC22A1 or OCT1, and SLC22A2 or OCT2), followed by application of machine-learning methods and ..
  82. Sauvant C, Hesse D, Holzinger H, Evans K, Dantzler W, Gekle M. Action of EGF and PGE2 on basolateral organic anion uptake in rabbit proximal renal tubules and hOAT1 expressed in human kidney epithelial cells. Am J Physiol Renal Physiol. 2004;286:F774-83 pubmed
    ..proximal (S2) tubules from rabbit and 2) in a human renal epithelial cell line stably expressing human OAT1 (IHKE-hOAT1)...
  83. Li L, Song F, Tu M, Wang K, Zhao L, Wu X, et al. In vitro interaction of clopidogrel and its hydrolysate with OCT1, OCT2 and OAT1. Int J Pharm. 2014;465:5-10 pubmed publisher
    ..organic cation transporter 1 (OCT1) (in liver), and CPC with organic cation transporter 2 (OCT2) and organic anion transporter 1 (OAT1) (in kidney)...
  84. Cihlar T, Lin D, Pritchard J, Fuller M, Mendel D, Sweet D. The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Mol Pharmacol. 1999;56:570-80 pubmed
    ..Importantly, both hOAT1 and rat renal organic anion transporter 1 (rROAT1) mediated saturable, probenecid-sensitive uptake of cidofovir, adefovir, and other ..
  85. Zalups R, Ahmad S. Handling of cysteine S-conjugates of methylmercury in MDCK cells expressing human OAT1. Kidney Int. 2005;68:1684-99 pubmed
    The activity of the organic anion transporter 1 (OAT1) has been implicated recently in the basolateral uptake of thiol conjugates of inorganic mercury in renal proximal tubular cells...
  86. Hagos Y, Krick W, Braulke T, Mühlhausen C, Burckhardt G, Burckhardt B. Organic anion transporters OAT1 and OAT4 mediate the high affinity transport of glutarate derivatives accumulating in patients with glutaric acidurias. Pflugers Arch. 2008;457:223-31 pubmed publisher
    ..The uptake of [(3)H]p-aminohippurate in hOAT1-transfected human embryonic kidney (HEK293) cells was inhibited by GA, 3OHGA, D: -, or L: -2OHGA in a ..
  87. Shin H, Lee C, Lee S, Song I, Shin J. Identification of genetic polymorphisms of human OAT1 and OAT2 genes and their relationship to hOAT2 expression in human liver. Clin Chim Acta. 2010;411:99-105 pubmed publisher
    ..These results suggest that genetic polymorphisms may not be a significant contributing factor to variations in the hOAT2 expression or hOAT2 transport activity. ..
  88. Elsby R, Fox L, Stresser D, Layton M, Butters C, Sharma P, et al. In vitro risk assessment of AZD9056 perpetrating a transporter-mediated drug-drug interaction with methotrexate. Eur J Pharm Sci. 2011;43:41-9 pubmed publisher
    ..The literature indicated active renal elimination (mediated by the human transporters OAT1, OAT3, MRP2 and BCRP) to be the principal pathway for methotrexate DDI risk...
  89. Kittayaruksakul S, Soodvilai S, Asavapanumas N, Muanprasat C, Chatsudthipong V. Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule. Am J Physiol Renal Physiol. 2012;302:F552-60 pubmed publisher
    ..In this study, we investigated the role of LXRs in the regulation of human organic anion transporter 1 (hOAT1), a major transporter localized in the basolateral membrane of the renal proximal tubule...
  90. Hu S, Leblanc A, Gibson A, Hong K, Kim J, Janke L, et al. Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity. Clin Transl Sci. 2017;10:412-420 pubmed publisher
    ..OCT2-independent pathway of cisplatin-induced renal injury that is mediated by the organic anion transporters OAT1 and OAT3...
  91. Wu T, Li H, Chen J, Cao Y, Fu W, Zhou P, et al. Apigenin, a novel candidate involving herb-drug interaction (HDI), interacts with organic anion transporter 1 (OAT1). Pharmacol Rep. 2017;69:1254-1262 pubmed publisher
    ..However, the mechanism by which apigenin interacts with OAT1 has not been well studied...
  92. Ekaratanawong S, Anzai N, Jutabha P, Miyazaki H, Noshiro R, Takeda M, et al. Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules. J Pharmacol Sci. 2004;94:297-304 pubmed
    ..apical membrane of proximal tubules along with those of basolateral organic anion/dicarboxylate exchangers such as hOAT1 and hOAT3 in the same tubular population...