Nurr1

Summary

Gene Symbol: Nurr1
Description: nuclear receptor subfamily 4 group A member 2
Alias: HZF-3, NOT, NURR1, RNR1, TINUR, nuclear receptor subfamily 4 group A member 2, NGFI-B/nur77 beta-type transcription factor homolog, T-cell nuclear receptor NOT, immediate-early response protein NOT, intermediate-early receptor protein, nuclear receptor related 1, nur related protein-1, human homolog of, orphan nuclear receptor NR4A2, orphan nuclear receptor NURR1, transcriptionally inducible nuclear receptor related 1, transcriptionally-inducible nuclear receptor
Species: human
Products:     Nurr1

Top Publications

  1. García Yagüe Á, Rada P, Rojo A, Lastres Becker I, Cuadrado A. Nuclear import and export signals control the subcellular localization of Nurr1 protein in response to oxidative stress. J Biol Chem. 2013;288:5506-17 pubmed publisher
    Orphan receptor Nurr1 participates in the acquisition and maintenance of the dopaminergic cell phenotype, modulation of inflammation, and cytoprotection, but little is known about its regulation...
  2. Ichinose H, Ohye T, Suzuki T, Sumi Ichinose C, Nomura T, Hagino Y, et al. Molecular cloning of the human Nurr1 gene: characterization of the human gene and cDNAs. Gene. 1999;230:233-9 pubmed
    b>Nurr1 is a member of the nuclear receptor superfamily of transcription factors that is expressed predominantly in the central nervous system, including developing dopaminergic neurons...
  3. Malewicz M, Kadkhodaei B, Kee N, Volakakis N, Hellman U, Viktorsson K, et al. Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair. Genes Dev. 2011;25:2031-40 pubmed publisher
    ..activity is entirely dispensable in this function, and core components of the DNA repair machinery are not transcriptionally regulated by NR4A...
  4. Aherne C, McMorrow J, Kane D, Fitzgerald O, Mix K, Murphy E. Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis. Mol Immunol. 2009;46:3345-57 pubmed publisher
    Expression of the orphan nuclear receptor NR4A2 is controlled by pro-inflammatory mediators, suggesting that NR4A2 may contribute to pathological processes in the inflammatory lesion...
  5. Maijenburg M, Gilissen C, Melief S, Kleijer M, Weijer K, ten Brinke A, et al. Nuclear receptors Nur77 and Nurr1 modulate mesenchymal stromal cell migration. Stem Cells Dev. 2012;21:228-38 pubmed publisher
    ..The nuclear receptors Nur77 and Nurr1 showed the highest expression in migratory MSC...
  6. Sleiman P, Healy D, Muqit M, Yang Y, van der Brug M, Holton J, et al. Characterisation of a novel NR4A2 mutation in Parkinson's disease brain. Neurosci Lett. 2009;457:75-9 pubmed publisher
    We performed a mutation screen of NR4A2 (also known as NURR1) in 409 Parkinson's disease (PD) patients. We identified a novel single base substitution in the 5'UTR of the NR4A2 (also known as NURR1) gene (c.-309C>T)...
  7. Torii T, Kawarai T, Nakamura S, Kawakami H. Organization of the human orphan nuclear receptor Nurr1 gene. Gene. 1999;230:225-32 pubmed
    Recent reports have revealed that Nurr1 (also known as NOT/TINUR/RNR-1/HZF-3), a member of the steroid/thyroid hormone nuclear receptor superfamily, is predominantly expressed in the midbrain; substantia nigra (SN) and ventral tegmental ..
  8. Liu H, Wei L, Tao Q, Deng H, Ming M, Xu P, et al. Decreased NURR1 and PITX3 gene expression in Chinese patients with Parkinson's disease. Eur J Neurol. 2012;19:870-5 pubmed publisher
    ..The transcription factors NURR1 and PITX3 have been shown to play a crucial role in the maturation and survival of mDA neurons, and both of them ..
  9. Tan E, Chung H, Chandran V, Tan C, Shen H, Yew K, et al. Nurr1 mutational screen in Parkinson's disease. Mov Disord. 2004;19:1503-5 pubmed
    ..None of the patients carried any pathogenic mutations in the Nurr1 gene...

More Information

Publications77

  1. Zhang T, Wang P, Ren H, Fan J, Wang G. NGFI-B nuclear orphan receptor Nurr1 interacts with p53 and suppresses its transcriptional activity. Mol Cancer Res. 2009;7:1408-15 pubmed publisher
    b>Nurr1 is a member of the NGFI-B nuclear orphan receptor family which includes two other members, Nur77 and Nor-1. Nurr1 is essential for the development and survival of dopaminergic neurons...
  2. Bannon M, Pruetz B, Manning Bog A, Whitty C, Michelhaugh S, Sacchetti P, et al. Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers. Proc Natl Acad Sci U S A. 2002;99:6382-5 pubmed
    ..This possibility has not been examined in the cocaine-exposed human brain. The transcription factor nurr1 is highly expressed in rodent midbrain dopamine neurons and is essential for their proper phenotypic development...
  3. LE W, Xu P, Jankovic J, Jiang H, Appel S, Smith R, et al. Mutations in NR4A2 associated with familial Parkinson disease. Nat Genet. 2003;33:85-9 pubmed
    ..map to the first exon of NR4A2 and affect one allele in 10 of 107 individuals with familial Parkinson disease but not in any individuals with sporadic Parkinson disease (n = 94) or in unaffected controls (n = 221)...
  4. Zheng K, Heydari B, Simon D. A common NURR1 polymorphism associated with Parkinson disease and diffuse Lewy body disease. Arch Neurol. 2003;60:722-5 pubmed
    b>NURR1 plays a key role in mesencephalic dopaminergic neuron development and survival. A homozygous NURR1 polymorphism (a single base-pair insertion in intron 6) (NI6P) has been reported to be associated with Parkinson disease (PD)...
  5. Berwick D, Harvey K. The importance of Wnt signalling for neurodegeneration in Parkinson's disease. Biochem Soc Trans. 2012;40:1123-8 pubmed
    ..This suggests the prospect of targeting Wnt signalling pathways to modify PD progression. ..
  6. Lu L, Sun X, Liu Y, Zhao H, Zhao S, Yang H. DJ-1 upregulates tyrosine hydroxylase gene expression by activating its transcriptional factor Nurr1 via the ERK1/2 pathway. Int J Biochem Cell Biol. 2012;44:65-71 pubmed publisher
    ..b>Nurr1, a transcriptional factor for tyrosine hydroxylase, can be phosphorylated by ERK1/2 and translocate to the nucleus,..
  7. Kadkhodaei B, Ito T, Joodmardi E, Mattsson B, Rouillard C, Carta M, et al. Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons. J Neurosci. 2009;29:15923-32 pubmed publisher
    ..b>Nurr1, one such transcription factor, is essential for early differentiation of midbrain dopamine (mDA) neurons but ..
  8. Wu Y, Peng R, Chen W, Zhang J, Li T, Wang Y, et al. [Association of the polymorphisms in NURR1 gene with Parkinson's disease]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008;25:693-6 pubmed
    To investigate the association between the polymorphisms of [c.-2922(C)2-3 and IVS6+ 18insG] in the NURR1 gene and Parkinson's disease (PD) in a Han population from Sichuan province...
  9. Xu P, Liang R, Jankovic J, Hunter C, Zeng Y, Ashizawa T, et al. Association of homozygous 7048G7049 variant in the intron six of Nurr1 gene with Parkinson's disease. Neurology. 2002;58:881-4 pubmed
    To determine whether the Nurr1 gene, which is critical for the development and maintenance of nigral dopaminergic neurons, is a risk factor associated with PD...
  10. Galleguillos D, Vecchiola A, Fuentealba J, Ojeda V, Alvarez K, Gomez A, et al. PIASgamma represses the transcriptional activation induced by the nuclear receptor Nurr1. J Biol Chem. 2004;279:2005-11 pubmed
    b>Nurr1 is a transcription factor essential for the development of ventral dopaminergic neurons...
  11. Wu Y, Ghosh S, Nishi Y, Yanase T, Nawata H, Hu Y. The orphan nuclear receptors NURR1 and NGFI-B modulate aromatase gene expression in ovarian granulosa cells: a possible mechanism for repression of aromatase expression upon luteinizing hormone surge. Endocrinology. 2005;146:237-46 pubmed
    ..Consistent with previous observations, the LH-responsive genes, such as the nuclear receptor 4A subfamily (NURR1, NGFI-B, and NOR-1), were rapidly but transiently induced, whereas the FSH-responsive gene CYP19 encoding ..
  12. Ke N, Claassen G, Yu D, Albers A, Fan W, Tan P, et al. Nuclear hormone receptor NR4A2 is involved in cell transformation and apoptosis. Cancer Res. 2004;64:8208-12 pubmed
  13. Ishiguro H, Okubo Y, Ohtsuki T, Yamakawa Kobayashi K, Arinami T. Mutation analysis of the retinoid X receptor beta, nuclear-related receptor 1, and peroxisome proliferator-activated receptor alpha genes in schizophrenia and alcohol dependence: possible haplotype association of nuclear-related receptor 1 gene to al. Am J Med Genet. 2002;114:15-23 pubmed
    ..Retinoid X receptors (RXRs) form heterodimer complexes with nuclear-related receptor 1 (NURR1) or with peroxisome proliferator-activated receptors (PPARs)...
  14. Nielsen D, Ji F, Yuferov V, Ho A, Chen A, Levran O, et al. Genotype patterns that contribute to increased risk for or protection from developing heroin addiction. Mol Psychiatry. 2008;13:417-28 pubmed publisher
    ..This approach has identified several new genes potentially associated with heroin addiction and has confirmed the role of OPRM1 in this disease...
  15. Wang J, Yang J, Zou Y, Huang G, He Z. Orphan nuclear receptor nurr1 as a potential novel marker for progression in human prostate cancer. Asian Pac J Cancer Prev. 2013;14:2023-8 pubmed
    A number of studies have indicated that Nurr1, which belongs to a novel class of orphan nuclear receptors (the NR4A family), is important for carcinogenesis...
  16. Li X, Tai H. Activation of thromboxane A(2) receptors induces orphan nuclear receptor Nurr1 expression and stimulates cell proliferation in human lung cancer cells. Carcinogenesis. 2009;30:1606-13 pubmed publisher
    ..2.1] hept-2-yl]-5-heptenoic acid (I-BOP), induced Nurr1 expression and stimulated proliferation of human lung cancer cells...
  17. Llopis S, Singleton B, Duplessis T, Carrier L, ROWAN B, Williams C. Dichotomous roles for the orphan nuclear receptor NURR1 in breast cancer. BMC Cancer. 2013;13:139 pubmed publisher
    ..The significance of NR4A family member NURR1 (NR4A2) in breast cancer etiology has not been elucidated...
  18. Arredondo C, Orellana M, Vecchiola A, Pereira L, Galdames L, Andrés M. PIAS? enhanced SUMO-2 modification of Nurr1 activation-function-1 domain limits Nurr1 transcriptional synergy. PLoS ONE. 2013;8:e55035 pubmed publisher
    b>Nurr1 (NR4A2) is a transcription factor that belongs to the orphan NR4A group of the nuclear receptor superfamily. Nurr1 plays key roles in the origin and maintenance of midbrain dopamine neurons, and peripheral inflammatory processes...
  19. Kim K, Kim C, Hwang D, Seo H, Chung S, Hong S, et al. Orphan nuclear receptor Nurr1 directly transactivates the promoter activity of the tyrosine hydroxylase gene in a cell-specific manner. J Neurochem. 2003;85:622-34 pubmed
    ..In the present study, we show that Nurr1, an orphan nuclear receptor critical for dopaminergic (DA) neuron development, directly transactivates the ..
  20. Mix K, Attur M, Al Mussawir H, Abramson S, Brinckerhoff C, Murphy E. Transcriptional repression of matrix metalloproteinase gene expression by the orphan nuclear receptor NURR1 in cartilage. J Biol Chem. 2007;282:9492-504 pubmed
    The NR4A orphan receptors (Nur77, NURR1, and NOR-1) are emerging as key regulators of cytokine and growth factor action in chronic inflammatory diseases...
  21. Wang Z, Benoit G, Liu J, Prasad S, Aarnisalo P, Liu X, et al. Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors. Nature. 2003;423:555-60 pubmed
    ..Here we report the crystal structure of the LBD of the orphan receptor Nurr1 at 2.2 A resolution...
  22. Nichols W, Uniacke S, Pankratz N, Reed T, Simon D, Halter C, et al. Evaluation of the role of Nurr1 in a large sample of familial Parkinson's disease. Mov Disord. 2004;19:649-55 pubmed
    ..Recently, a polymorphic variant within intron 6 of the Nurr1 gene was reported to be associated with sporadic and familial PD...
  23. Holla V, Mann J, Shi Q, DuBois R. Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancer. J Biol Chem. 2006;281:2676-82 pubmed
    ..target genes in colorectal carcinoma cells and report here that an immediate early gene, nuclear factor NR4A2 (Nurr1), is induced by PGE2 that in turn regulates cell death...
  24. Jankovic J, Chen S, Le W. The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease. Prog Neurobiol. 2005;77:128-38 pubmed
    b>Nurr1, a transcription factor belonging to the orphan nuclear receptor superfamily, is critical in the development and maintenance of the dopaminergic system and as such it may have role in the pathogenesis of Parkinson' disease (PD)...
  25. Pei L, Castrillo A, Chen M, Hoffmann A, Tontonoz P. Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli. J Biol Chem. 2005;280:29256-62 pubmed
    ..lipopolysaccharide (LPS), cytokines, or oxidized lipids triggers the transcriptional induction of Nur77 (NR4A1), Nurr1 (NR4A2), and NOR1 (NR4A3) expression...
  26. Bonta P, Van Tiel C, Vos M, Pols T, van Thienen J, Ferreira V, et al. Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses. Arterioscler Thromb Vasc Biol. 2006;26:2288-94 pubmed
    ..study, we investigated expression and function of the NR4A nuclear receptor family, comprising Nur77 (NR4A1, TR3), Nurr1 (NR4A2), and NOR-1 (NR4A3) in human macrophages...
  27. Yang Y, Latchman D. Nurr1 transcriptionally regulates the expression of alpha-synuclein. Neuroreport. 2008;19:867-71 pubmed publisher
    ..Mutations in Nurr1 leading to a reduction in expression were also found to lead to Parkinson's disease...
  28. Horvath M, Kovacs G, Kovari V, Majtenyi K, Hurd Y, Keller E. Heroin abuse is characterized by discrete mesolimbic dopamine and opioid abnormalities and exaggerated nuclear receptor-related 1 transcriptional decline with age. J Neurosci. 2007;27:13371-5 pubmed
    ..DAT), tyrosine hydroxylase (TH), dopamine D2 receptor, alpha-synuclein, and nuclear receptor-related 1 (Nurr1) in discrete mesocorticolimbic and nigrostriatal subpopulations of heroin users and control subjects...
  29. Chang W, Ma L, Lin L, Gu L, Liu X, Cai H, et al. Identification of novel hub genes associated with liver metastasis of gastric cancer. Int J Cancer. 2009;125:2844-53 pubmed publisher
    ..HSP90AA1 was not only up-regulated in the metastatic GC compared with primary GC at both transcriptional and translational levels, ..
  30. Le W, Pan T, Huang M, Xu P, Xie W, Zhu W, et al. Decreased NURR1 gene expression in patients with Parkinson's disease. J Neurol Sci. 2008;273:29-33 pubmed publisher
    b>NURR1 is a transcription factor essential for the development, survival, and functional maintenance of midbrain dopaminergic (DAergic) neurons and NURR1 is a potential susceptibility gene for Parkinson's disease (PD)...
  31. Lee H, Bae E, Yi S, Shim J, Jo A, Kang J, et al. Foxa2 and Nurr1 synergistically yield A9 nigral dopamine neurons exhibiting improved differentiation, function, and cell survival. Stem Cells. 2010;28:501-12 pubmed publisher
    ..b>Nurr1, an orphan nuclear receptor, has been reported as a transcription factor that can drive DA neuron differentiation ..
  32. Martinat C, Bacci J, Leete T, Kim J, Vanti W, Newman A, et al. Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype. Proc Natl Acad Sci U S A. 2006;103:2874-9 pubmed
    ..development of midbrain DA neurons by expression analyses and loss-of-function knockout mouse studies, including Nurr1, Pitx3, Lmx1b, Engrailed-1, and Engrailed-2...
  33. Perlmann T, Jansson L. A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1. Genes Dev. 1995;9:769-82 pubmed
    ..Here, we show that two orphan receptors, NGFI-B and NURR1, which have been shown previously to interact with DNA as monomers, also can heterodimerize with RXR...
  34. Jacobs F, van Erp S, van der Linden A, von Oerthel L, Burbach J, Smidt M. Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression. Development. 2009;136:531-40 pubmed publisher
    ..Thus far, specification of the dopaminergic phenotype of mdDA neurons is largely attributed to the orphan nuclear receptor Nurr1. In this study, we provide evidence for extensive interplay between Nurr1 and the homeobox ..
  35. Inamoto T, Papineni S, Chintharlapalli S, Cho S, Safe S, Kamat A. 1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth. Mol Cancer Ther. 2008;7:3825-33 pubmed publisher
    b>Nurr1 is an orphan nuclear receptor and a member of the nerve growth factor I-B subfamily of transcription factors with no known endogenous ligand or stimulator...
  36. Smith A, Luk N, Newton R, Roberts D, Sturm R, Muscat G. Melanocortin-1 receptor signaling markedly induces the expression of the NR4A nuclear receptor subgroup in melanocytic cells. J Biol Chem. 2008;283:12564-70 pubmed publisher
    ..These data identify the NR4A receptor family as potential mediators of an MC1R-coordinated DNA damage response to UV exposure in melanocytic cells. ..
  37. Wu X, An X, Zhang C, Huang M. Clb6-Cdc28 Promotes Ribonucleotide Reductase Subcellular Redistribution during S Phase. Mol Cell Biol. 2018;38: pubmed publisher
    ..cerevisiae, the RNR small subunit, Rnr2-Rnr4, is localized to the nucleus, whereas the large subunit, Rnr1, is cytoplasmic...
  38. Chen Y, Wang Z, Wang Z, Chen D, Chai Y, Pang X, et al. Targeted next-generation sequencing in Uyghur families with non-syndromic sensorineural hearing loss. PLoS ONE. 2015;10:e0127879 pubmed publisher
    ..consanguineous and two multiplex Uyghur families in which mutations in common deafness genes GJB2, SLC26A4 and MT-RNR1 were excluded...
  39. Giner X, Cotnoir White D, Mader S, Lévesque D. Selective ligand activity at Nur/retinoid X receptor complexes revealed by dimer-specific bioluminescence resonance energy transfer-based sensors. FASEB J. 2015;29:4256-67 pubmed publisher
    ..we compared rexinoid modulation of CoA recruitment by the RXR homodimer and by the heterodimers Nur77/RXR and Nurr1/RXR...
  40. Malhotra S, Gupta S. Relevance of the NR4A sub-family of nuclear orphan receptors in trophoblastic BeWo cell differentiation. Cell Mol Biol Lett. 2017;22:15 pubmed publisher
    ..Silencing Nor-1, Nurr-1 or Nur-77 individually did not show any effect on forskolin-, hCG- and/or GnRH-mediated BeWo cell fusion and/or hCG secretion...
  41. Wingate A, Campbell D, Peggie M, Arthur J. Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation. Biochem J. 2006;393:715-24 pubmed
    ..We have established that two related proteins, Nurr1 and Nor1, are also phosphorylated on the equivalent site by RSK in cells in response to mitogenic stimulation.
  42. Ding Y, Xia B, Liu Q, Li M, Huang S, Zhuo G. Allele-specific PCR for detecting the deafness-associated mitochondrial 12S rRNA mutations. Gene. 2016;591:148-152 pubmed publisher
    Mutations in mitochondrial 12S rRNA (MT-RNR1) are the important causes of sensorineural hearing loss. Of these mutations, the homoplasmic m.1555A>G or m...
  43. Theodorou M, Rauser B, Zhang J, Prakash N, Wurst W, Schick J. Limitations of In Vivo Reprogramming to Dopaminergic Neurons via a Tricistronic Strategy. Hum Gene Ther Methods. 2015;26:107-22 pubmed publisher
    ..to dopaminergic neurons, we generated a Rosa26 knock-in mouse line conditionally overexpressing Mash1, Lmx1a, and Nurr1. These proteins are characterized by their role in neuronal commitment and development of midbrain dopaminergic ..
  44. Montarolo F, Perga S, Martire S, Bertolotto A. Nurr1 reduction influences the onset of chronic EAE in mice. Inflamm Res. 2015;64:841-4 pubmed publisher
    b>Nurr1 plays anti-inflammatory functions in astrocytes/microglia. Gene expression analysis reveals Nurr1 down-regulation in PBMCs of MS patients that negatively correlates with disease aggressiveness...
  45. Kouwenhoven W, von Oerthel L, Smidt M. Pitx3 and En1 determine the size and molecular programming of the dopaminergic neuronal pool. PLoS ONE. 2017;12:e0182421 pubmed publisher
    ..5. These mdDA neurons have a rudimentary dopaminergic cell fate, as they express Nurr1, Pbx3 and Otx2 but have lost their rostral or caudal subset identity...
  46. Jodeiri Farshbaf M, Forouzanfar M, Ghaedi K, Kiani Esfahani A, Peymani M, Shoaraye Nejati A, et al. Nurr1 and PPAR? protect PC12 cells against MPP(+) toxicity: involvement of selective genes, anti-inflammatory, ROS generation, and antimitochondrial impairment. Mol Cell Biochem. 2016;420:29-42 pubmed publisher
    ..b>Nuclear receptor related 1 protein (Nurr1) is, respectively, member of NR4A family and has received great attentions as potential ..
  47. Lim M, Chang M, Kim S, Yi S, Suh Kim H, Jung S, et al. Generation of Dopamine Neurons from Rodent Fibroblasts through the Expandable Neural Precursor Cell Stage. J Biol Chem. 2015;290:17401-14 pubmed publisher
    ..Specifically, overexpression of Nurr1 and Foxa2, transcription factors specific for midbrain dopamine neuron development, drove iNPCs to yield mature ..
  48. Jiang H, Xu Z, Zhong P, Ren Y, Liang G, Schilling H, et al. Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons. Nat Commun. 2015;6:10100 pubmed publisher
    ..markedly increase the efficiency in the transdifferentiation of human fibroblasts to iDA neurons by Ascl1, Nurr1, Lmx1a and miR124...
  49. Guan D, Tian H. Integrated network analysis to explore the key genes regulated by parathyroid hormone receptor 1 in osteosarcoma. World J Surg Oncol. 2017;15:177 pubmed publisher
    ..In addition, LEF1, NR4A2, HAS2, and RHOC had higher degrees in the integrated network. ZFPM2, LEF1, NR4A2, HAS2, and RHOC might be potential targets of PTHR1 in OS. ..
  50. Espadas Alvarez A, Bannon M, Orozco Barrios C, Escobedo Sanchez L, Ayala Davila J, Reyes Corona D, et al. Regulation of human GDNF gene expression in nigral dopaminergic neurons using a new doxycycline-regulated NTS-polyplex nanoparticle system. Nanomedicine. 2017;13:1363-1375 pubmed publisher
    ..Transient transfection experiments in N1E-115-Nurr1 cells showed that doxycycline (100 ng/mL) activates hGDNF and GFP expression. Doxycycline (5 mg/kg, i.p...
  51. Alavian K, Jeddi S, Naghipour S, Nabili P, Licznerski P, Tierney T. The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailed. J Biomed Sci. 2014;21:27 pubmed publisher
    ..The current review describes the role of two such factors, Nurr1 and engrailed, in differentiation, maturation, and in normal physiological functions including acquisition of ..
  52. Montes P, Ruiz Sánchez E, Calvillo M, Rojas P. Active coping of prenatally stressed rats in the forced swimming test: involvement of the Nurr1 gene. Stress. 2016;19:506-15 pubmed publisher
    ..b>Nurr1 is an immediate early gene, important in the brain for the stress response...
  53. Puglisi M, Barba M, Corbi M, Errico M, Giorda E, Saulnier N, et al. Identification of Endothelin-1 and NR4A2 as CD133-regulated genes in colon cancer cells. J Pathol. 2011;225:305-14 pubmed publisher
    ..In conclusion, we have identified a molecular signature associated with potential CSCs and showed for the first time the existence of a functional relationship between CD133, END-1 and NR4A2 expression in colon cancer cells. ..
  54. Baljinnyam E, Venkatesh S, Gordan R, Mareedu S, Zhang J, Xie L, et al. Effect of densely ionizing radiation on cardiomyocyte differentiation from human-induced pluripotent stem cells. Physiol Rep. 2017;5: pubmed publisher
    ..Increased transcript expression of mitochondrial biomarkers (LONP1, TFAM) and mtDNA-encoded genes (MT-CYB, MT-RNR1) was detected upon differentiation of hiPSC-CMs suggesting increased organelle biogenesis...
  55. Jagirdar K, Yin K, Harrison M, Lim W, Muscat G, Sturm R, et al. The NR4A2 nuclear receptor is recruited to novel nuclear foci in response to UV irradiation and participates in nucleotide excision repair. PLoS ONE. 2013;8:e78075 pubmed publisher
    ..Taken together these data uncover a novel role for the NR4A nuclear receptors as direct facilitators of nucleotide excision repair. ..
  56. Noda M, Ohno S, Nakajin S. Mono-(2-ethylhexyl) phthalate (MEHP) induces nuclear receptor 4A subfamily in NCI-H295R cells: a possible mechanism of aromatase suppression by MEHP. Mol Cell Endocrinol. 2007;274:8-18 pubmed
    ..and transiently induced transcription of the genes which encode nuclear receptor 4A subfamily members (Nur77, Nurr1 and NOR-1), and up-regulated Nur77 promoter activation and Nur77 protein expression in the cells...
  57. Zhang T, Jia N, Fei E, Wang P, Liao Z, Ding L, et al. Nurr1 is phosphorylated by ERK2 in vitro and its phosphorylation upregulates tyrosine hydroxylase expression in SH-SY5Y cells. Neurosci Lett. 2007;423:118-22 pubmed
    b>Nurr1 is an orphan nuclear receptor essential for development and survival of dopaminergic neurons...
  58. Ham A, Lee H, Hong S, Lee D, Mar W. Moracenin D from Mori Cortex radicis protects SH-SY5Y cells against dopamine-induced cell death by regulating nurr1 and ?-synuclein expression. Phytother Res. 2012;26:620-4 pubmed publisher
    ..cell death was examined, and the subsequent effects on the levels of expression of Parkinson's disease-associated nurr1 and ?-synuclein were evaluated in a dopamine-induced system...
  59. McEvoy A, Murphy E, Ponnio T, Conneely O, Bresnihan B, Fitzgerald O, et al. Activation of nuclear orphan receptor NURR1 transcription by NF-kappa B and cyclic adenosine 5'-monophosphate response element-binding protein in rheumatoid arthritis synovial tissue. J Immunol. 2002;168:2979-87 pubmed
    ..Markedly enhanced expression of NURR1 is observed in synovial tissue of patients with RA compared with normal subjects...
  60. Okabe T, Takayanagi R, Imasaki K, Haji M, Nawata H, Watanabe T. cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line. J Immunol. 1995;154:3871-9 pubmed
    A human T lymphoid cell line, PEER, dies by apoptosis in the presence of PMA and calcium ionophore. A new gene, TINUR, was cloned from apoptotic PEER cells...
  61. Wang J, Yang Z, Chen H, Li H, Chen L, Zhu Z, et al. Nemo-like kinase as a negative regulator of nuclear receptor Nurr1 gene transcription in prostate cancer. BMC Cancer. 2016;16:257 pubmed publisher
    b>Nurr1, a member of the orphan receptor family, plays an important role in several types of cancer...
  62. Ibanez P, Lohmann E, Pollak P, Durif F, Tranchant C, Agid Y, et al. Absence of NR4A2 exon 1 mutations in 108 families with autosomal dominant Parkinson disease. Neurology. 2004;62:2133-4 pubmed
  63. Han Y, Cai H, Ma L, Ding Y, Tan X, Chang W, et al. Expression of orphan nuclear receptor NR4A2 in gastric cancer cells confers chemoresistance and predicts an unfavorable postoperative survival of gastric cancer patients with chemotherapy. Cancer. 2013;119:3436-45 pubmed publisher
    ..011), especially for those who received 5-fluorouracil-based chemotherapy (P?=?.016). This effect was not found in those without the chemotherapy...
  64. Watanuki Y, Takayasu S, Kageyama K, Iwasaki Y, Sakihara S, Terui K, et al. Involvement of Nurr-1/Nur77 in corticotropin-releasing factor/urocortin1-induced tyrosinase-related protein 1 gene transcription in human melanoma HMV-II cells. Mol Cell Endocrinol. 2013;370:42-51 pubmed publisher
    ..The findings suggest that in human melanoma HMV-II cells both CRF and Ucn1 regulate TRP1 gene expression via Nurr-1/Nur77 production, independent of pro-opiomelanocortin or ?-melanocyte-stimulating hormone stimulation. ..
  65. Yue P, Gao L, Wang X, Ding X, Teng J. Ultrasound-triggered effects of the microbubbles coupled to GDNF- and Nurr1-loaded PEGylated liposomes in a rat model of Parkinson's disease. J Cell Biochem. 2018;119:4581-4591 pubmed publisher
    ..effects of the glial cell line-derived neurotrophic factor (GDNF) + nuclear receptor-related factor 1 (Nurr1)-polyethylene glycol (PEG)ylated liposomes-coupled microbubbles (PLs-GDNF + Nurr1-MBs) on behavioral ..
  66. Zu G, Yao J, Ji A, Ning S, Luo F, Li Z, et al. Nurr1 promotes intestinal regeneration after ischemia/reperfusion injury by inhibiting the expression of p21 (Waf1/Cip1). J Mol Med (Berl). 2017;95:83-95 pubmed publisher
    ..Here, we reported that nuclear receptor-related protein 1 (Nurr1), a nuclear orphan receptor, was induced during intestinal regeneration after I/R...
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    ..HDACs are known to be powerful negative regulators of memory formation, but it is not clear whether this function depends on HDAC enzymatic activity per se...
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    ..In 2003, two mutations were identified in exon 1 of the Nurr1 gene in 10 of 107 individuals with familial PD...