Nur77

Summary

Gene Symbol: Nur77
Description: nuclear receptor subfamily 4 group A member 1
Alias: GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3, nuclear receptor subfamily 4 group A member 1, ST-59, TR3 orphan receptor, early response protein NAK1, growth factor-inducible nuclear protein N10, hormone receptor, nerve growth factor IB nuclear receptor variant 1, nuclear hormone receptor NUR/77, orphan nuclear receptor HMR, orphan nuclear receptor TR3, steroid receptor TR3, testicular receptor 3
Species: human
Products:     Nur77

Top Publications

  1. Liang B, Song X, Liu G, Li R, Xie J, Xiao L, et al. Involvement of TR3/Nur77 translocation to the endoplasmic reticulum in ER stress-induced apoptosis. Exp Cell Res. 2007;313:2833-44 pubmed
    Nuclear orphan receptor TR3/Nur77/NGFI-B is a novel apoptotic effector protein that initiates apoptosis largely by translocating from the nucleus to the mitochondria, causing the release of cytochrome c...
  2. Zhou F, Drabsch Y, Dekker T, de Vinuesa A, Li Y, Hawinkels L, et al. Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-? signalling. Nat Commun. 2014;5:3388 pubmed publisher
    ..Our results uncover inflammation-induced NR4A1 as an important determinant for hyperactivation of pro-oncogenic TGF-? signalling in breast cancer. ..
  3. Li M, Xue K, Ling J, Diao F, Cui Y, Liu J. The orphan nuclear receptor NR4A1 regulates transcription of key steroidogenic enzymes in ovarian theca cells. Mol Cell Endocrinol. 2010;319:39-46 pubmed publisher
    ..Modulation of these steroidogenic enzymes by NR4A1 could influence the capacity of the ovarian theca cells to produce androgen...
  4. Hinze A, Mayer P, Harst A, von Kügelgen I. P2X1 receptor-mediated inhibition of the proliferation of human coronary smooth muscle cells involving the transcription factor NR4A1. Purinergic Signal. 2013;9:677-86 pubmed publisher
    ..proliferation by the induction of the nuclear receptor subfamily 4, group A, member 1 (NR4A1; alternative notation Nur77)...
  5. Winoto A, Littman D. Nuclear hormone receptors in T lymphocytes. Cell. 2002;109 Suppl:S57-66 pubmed
    ..We review here recent studies on the glucocorticoid receptor and the orphan receptors Nur77 and RORgamma. These molecules play key roles in the development and the effector functions of T lymphocytes.
  6. Sun Z, Cao X, Jiang M, Qiu Y, Zhou H, Chen L, et al. Inhibition of ?-catenin signaling by nongenomic action of orphan nuclear receptor Nur77. Oncogene. 2012;31:2653-67 pubmed publisher
    ..b>Nur77, an orphan member of the nuclear receptor superfamily, has a role in the growth and apoptosis of cancer cells...
  7. Zhang X, Yan G, Diao Z, Sun H, Hu Y. NUR77 inhibits the expression of TIMP2 and increases the migration and invasion of HTR-8/SVneo cells induced by CYR61. Placenta. 2012;33:561-7 pubmed publisher
    ..To investigate the function and mechanism of CYR61 on the migration and invasion of the trophoblast cell line, HTR-8/SVneo cells...
  8. Zhao B, Chen H, Du X, Luo J, He J, Wang R, et al. Orphan receptor TR3 enhances p53 transactivation and represses DNA double-strand break repair in hepatoma cells under ionizing radiation. Mol Endocrinol. 2011;25:1337-50 pubmed publisher
    ..Herein, we demonstrate that the orphan nuclear receptor TR3 suppresses DSB repair by blocking Ku80 DNA-end binding activity and promoting DNA-PK-induced p53 ..
  9. Cho S, Lee S, Chintharlapalli S, Abdelrahim M, Khan S, Yoon K, et al. Activation of nerve growth factor-induced B alpha by methylene-substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth. Mol Pharmacol. 2010;77:396-404 pubmed publisher
    Nerve growth factor-induced B (NGFI-B) genes are orphan nuclear receptors, and NGFI-B alpha (Nur77, TR3) is overexpressed in bladder tumors and bladder cancer cells compared with nontumorous bladder tissue...

More Information

Publications80

  1. Kolluri S, Bruey Sedano N, Cao X, Lin B, Lin F, Han Y, et al. Mitogenic effect of orphan receptor TR3 and its regulation by MEKK1 in lung cancer cells. Mol Cell Biol. 2003;23:8651-67 pubmed
    TR3, also known as NGFI-B or nur77, is an immediate-early response gene and an orphan member of the steroid/thyroid/retinoid receptor superfamily...
  2. Wu Q, Liu S, Ye X, Huang Z, Su W. Dual roles of Nur77 in selective regulation of apoptosis and cell cycle by TPA and ATRA in gastric cancer cells. Carcinogenesis. 2002;23:1583-92 pubmed
    b>Nur77 is an orphan receptor...
  3. Zhao B, Chen H, Lei N, Li G, Zhao W, Zhan Y, et al. p53 mediates the negative regulation of MDM2 by orphan receptor TR3. EMBO J. 2006;25:5703-15 pubmed
    ..The expression level of MDM2 is negatively regulated by orphan receptor TR3 that mainly acts as a transcriptional factor to regulate gene expression...
  4. Chtarbova S, Nimmrich I, Erdmann S, Herter P, Renner M, Kitajewski J, et al. Murine Nr4a1 and Herpud1 are up-regulated by Wnt-1, but the homologous human genes are independent from beta-catenin activation. Biochem J. 2002;367:723-8 pubmed
    ..These results indicate different regulation mechanisms of the two genes in murine and human cells. ..
  5. Han Y, Cao X, Lin B, Lin F, Kolluri S, Stebbins J, et al. Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt. Oncogene. 2006;25:2974-86 pubmed
    Proapoptotic nuclear receptor family member Nur77 translocates from the nucleus to the mitochondria, where it interacts with Bcl-2 to trigger apoptosis...
  6. Choi J, Park S, Kang G, Liu J, Youn H. Nur77 activated by hypoxia-inducible factor-1alpha overproduces proopiomelanocortin in von Hippel-Lindau-mutated renal cell carcinoma. Cancer Res. 2004;64:35-9 pubmed
    ..A critical transcription factor responsible for POMC overproduction was identified as Nur77, a member of the orphan steroid receptor superfamily...
  7. Yu H, Kumar S, Fang D, Acs G, Xu X. Nuclear orphan receptor TR3/Nur77 mediates melanoma cell apoptosis. Cancer Biol Ther. 2007;6:405-12 pubmed
    b>TR3 was originally recognized for its role in the regulation of cell survival and differentiation, however, it was recently found to be a potent pro-apoptotic protein...
  8. Liu B, Wu J, Zhan Y, Chen H, Zhang X, Wu Q. Regulation of the orphan receptor TR3 nuclear functions by c-Jun N terminal kinase phosphorylation. Endocrinology. 2007;148:34-44 pubmed
    The orphan receptor TR3 functions in the nucleus as a transcription factor to negatively or positively regulate gene expression...
  9. Pei L, Castrillo A, Chen M, Hoffmann A, Tontonoz P. Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli. J Biol Chem. 2005;280:29256-62 pubmed
    ..macrophages with lipopolysaccharide (LPS), cytokines, or oxidized lipids triggers the transcriptional induction of Nur77 (NR4A1), Nurr1 (NR4A2), and NOR1 (NR4A3) expression...
  10. Kang S, Na H, Kang H, Kim S, Lee M, Lee M. Regulation of Nur77 protein turnover through acetylation and deacetylation induced by p300 and HDAC1. Biochem Pharmacol. 2010;80:867-73 pubmed publisher
    Although the roles of Nur77, an orphan member of the nuclear hormone receptor superfamily, in the control of cellular proliferation, apoptosis, inflammation, and glucose metabolism, are well recognized, the molecular mechanism regulating ..
  11. Wu H, Lin Y, Li W, Sun Z, Gao W, Zhang H, et al. Regulation of Nur77 expression by ?-catenin and its mitogenic effect in colon cancer cells. FASEB J. 2011;25:192-205 pubmed publisher
    The orphan nuclear receptor Nur77 is an immediate-early response gene whose expression is rapidly induced by various extracellular stimuli...
  12. Wansa K, Harris J, Muscat G. The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment. J Biol Chem. 2002;277:33001-11 pubmed
    Nur77/NR4A1 is an "orphan member" of the nuclear hormone receptor superfamily...
  13. Bonta P, Van Tiel C, Vos M, Pols T, van Thienen J, Ferreira V, et al. Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses. Arterioscler Thromb Vasc Biol. 2006;26:2288-94 pubmed
    ..In this study, we investigated expression and function of the NR4A nuclear receptor family, comprising Nur77 (NR4A1, TR3), Nurr1 (NR4A2), and NOR-1 (NR4A3) in human macrophages...
  14. de Léséleuc L, Denis F. Inhibition of apoptosis by Nur77 through NF-kappaB activity modulation. Cell Death Differ. 2006;13:293-300 pubmed
    The orphan nuclear receptor Nur77 has been described as a mediator of apoptosis and has also been associated with growth promotion and apoptotic resistance...
  15. Lee S, Andey T, Jin U, Kim K, Singh M, Sachdeva M, et al. The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53. Oncogene. 2012;31:3265-76 pubmed publisher
    The orphan nuclear receptor TR3 (NR41A and Nur77) is overexpressed in most lung cancer patients and is a negative prognostic factor for patient survival...
  16. Lin B, Kolluri S, Lin F, Liu W, Han Y, Cao X, et al. Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. Cell. 2004;116:527-40 pubmed
    ..Here, we show that Bcl-2 interacts with orphan nuclear receptor Nur77 (also known as TR3), which is required for cancer cell apoptosis induced by many antineoplastic agents...
  17. Castro Obregon S, Rao R, Del Rio G, Chen S, Poksay K, Rabizadeh S, et al. Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77. J Biol Chem. 2004;279:17543-53 pubmed
    ..ERK2 is essential for this form of nonapoptotic pcd, leading to the phosphorylation of the orphan nuclear receptor Nur77. NK(1)R-mediated cell death was inhibited by a dominant negative form of arrestin 2, Raf-1, or Nur77, by MEK1/2-..
  18. Martin L, Tremblay J. The human 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase type 2 promoter is a novel target for the immediate early orphan nuclear receptor Nur77 in steroidogenic cells. Endocrinology. 2005;146:861-9 pubmed
    ..A role for the Nur77 family of immediate-early orphan nuclear receptors in steroidogenesis has received recent interest...
  19. Wu Y, Ghosh S, Nishi Y, Yanase T, Nawata H, Hu Y. The orphan nuclear receptors NURR1 and NGFI-B modulate aromatase gene expression in ovarian granulosa cells: a possible mechanism for repression of aromatase expression upon luteinizing hormone surge. Endocrinology. 2005;146:237-46 pubmed
  20. Bassett M, Suzuki T, Sasano H, de Vries C, Jimenez P, Carr B, et al. The orphan nuclear receptor NGFIB regulates transcription of 3beta-hydroxysteroid dehydrogenase. implications for the control of adrenal functional zonation. J Biol Chem. 2004;279:37622-30 pubmed
    ..real time reverse transcriptase-PCR, immunohistochemistry, and HSD3B2 promoter analysis, we demonstrate that the NGFIB family of nuclear hormone receptors plays a critical part in the regulation of HSD3B2 transcription and may play ..
  21. Wilson A, Arango D, Mariadason J, Heerdt B, Augenlicht L. TR3/Nur77 in colon cancer cell apoptosis. Cancer Res. 2003;63:5401-7 pubmed
    The orphan nuclear receptor TR3/Nur77 has emerged as a viable candidate in the coordinate regulation of cell proliferation and apoptosis, essential for maintaining normal architecture in rapidly renewing tissues such as the colonic ..
  22. Wingate A, Campbell D, Peggie M, Arthur J. Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation. Biochem J. 2006;393:715-24 pubmed
    b>Nur77 is a nuclear orphan receptor that is able to activate transcription independently of exogenous ligand, and has also been shown to promote apoptosis on its localization to mitochondria...
  23. Zhan Y, He J, Chen H, Wang W, Cai J. Orphan receptor TR3 is essential for the maintenance of stem-like properties in gastric cancer cells. Cancer Lett. 2013;329:37-44 pubmed publisher
    The orphan receptor TR3 is an important regulator of cell proliferation and apoptosis. However, whether TR3 is involved in regulating the stem-like properties of cancer cells remains unknown...
  24. Slagsvold H, Østvold A, Fallgren A, Paulsen R. Nuclear receptor and apoptosis initiator NGFI-B is a substrate for kinase ERK2. Biochem Biophys Res Commun. 2002;291:1146-50 pubmed
    ..These results suggest that NGFI-B may be a molecular target for ERK2 signals and thereby a substrate for crosstalk between a growth factor survival pathway and an inducible regulator of apoptosis. ..
  25. Chintharlapalli S, Burghardt R, Papineni S, Ramaiah S, Yoon K, Safe S. Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways. J Biol Chem. 2005;280:24903-14 pubmed
    b>Nur77 is an orphan receptor and a member of the nerve growth factor-I-B subfamily of the nuclear receptor family of transcription factors...
  26. Cao X, Liu W, Lin F, Li H, Kolluri S, Lin B, et al. Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting. Mol Cell Biol. 2004;24:9705-25 pubmed
    ..by acting as a ubiquitous heterodimerization partner of many nuclear receptors, including the orphan receptor Nur77 (also known as TR3 [corrected] or NGFI-B), which translocates from the nucleus to mitochondria, where it interacts ..
  27. Ye X, Wu Q, Liu S, Lin X, Zhang B, Wu J, et al. Distinct role and functional mode of TR3 and RARalpha in mediating ATRA-induced signalling pathway in breast and gastric cancer cells. Int J Biochem Cell Biol. 2004;36:98-113 pubmed
    ..Besides these, other receptors such as orphan receptor TR3, are also involved in the regulatory process of ATRA...
  28. You B, Jiang Y, Chen S, Yan G, Sun J. The orphan nuclear receptor Nur77 suppresses endothelial cell activation through induction of IkappaBalpha expression. Circ Res. 2009;104:742-9 pubmed publisher
    ..b>Nur77 is highly expressed in vascular endothelial cells (ECs) and plays a role in the regulation of cell proliferation ..
  29. Alexopoulou A, Leao M, Caballero O, Da Silva L, Reid L, Lakhani S, et al. Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell lines. Breast Cancer Res. 2010;12:R51 pubmed publisher
    ..It is therefore possible that NR4A1 acts as an antimigratory factor in breast tumours, and further studies should be conducted to understand the mechanisms involved. ..
  30. Kolluri S, Zhu X, Zhou X, Lin B, Chen Y, Sun K, et al. A short Nur77-derived peptide converts Bcl-2 from a protector to a killer. Cancer Cell. 2008;14:285-98 pubmed publisher
    Bcl-2 can be converted into a proapoptotic molecule by nuclear receptor Nur77. However, the development of Bcl-2 converters as anticancer therapeutics has not been explored...
  31. Jiang Y, Hu Y, Zhao J, Zhen X, Yan G, Sun H. The orphan nuclear receptor Nur77 regulates decidual prolactin expression in human endometrial stromal cells. Biochem Biophys Res Commun. 2011;404:628-33 pubmed publisher
    ..Here we present evidence that the transcription factor Nur77 plays an active role in decidual prolactin expression in human endometrial stromal cells (hESCs)...
  32. Mullican S, Zhang S, Konopleva M, Ruvolo V, Andreeff M, Milbrandt J, et al. Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia. Nat Med. 2007;13:730-5 pubmed
    b>Nur77 (NR4A1) and Nor-1 (NR4A3) are highly homologous orphan nuclear receptors that regulate the transcription of overlapping target genes...
  33. Ding L, Yan G, Ge Q, Yu F, Zhao X, Diao Z, et al. FSH acts on the proliferation of type A spermatogonia via Nur77 that increases GDNF expression in the Sertoli cells. FEBS Lett. 2011;585:2437-44 pubmed publisher
    ..In the present study, FSH induced the expression of Nur77 and GDNF in mouse testis tissue and human fetal Sertoli cells...
  34. Li H, Kolluri S, Gu J, Dawson M, Cao X, Hobbs P, et al. Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. Science. 2000;289:1159-64 pubmed
    b>TR3, an immediate-early response gene and an orphan member of the steroid-thyroid hormone-retinoid receptor superfamily of transcription factors, regulates apoptosis through an unknown mechanism...
  35. Yoo Y, Yeo M, Kim D, Park H, Lee M. Novel function of orphan nuclear receptor Nur77 in stabilizing hypoxia-inducible factor-1alpha. J Biol Chem. 2004;279:53365-73 pubmed
    ..Here, we show that the orphan nuclear receptor Nur77 is an important regulator of HIF-1alpha...
  36. Engelberg J, Retallack H, Balassanian R, Dowsett M, Zabaglo L, Ram A, et al. "Score the Core" Web-based pathologist training tool improves the accuracy of breast cancer IHC4 scoring. Hum Pathol. 2015;46:1694-704 pubmed publisher
    b>Hormone receptor status is an integral component of decision-making in breast cancer management...
  37. van Bommel A, Mureau M, Schreuder K, van Dalen T, Vrancken Peeters M, Schrieks M, et al. Large variation between hospitals in immediate breast reconstruction rates after mastectomy for breast cancer in the Netherlands. J Plast Reconstr Aesthet Surg. 2017;70:215-221 pubmed publisher
    ..A large variation between hospitals was found in postmastectomy IBR rates in the Netherlands for both invasive breast cancer and DCIS even after adjustment for patient and tumor factors. ..
  38. Cole B, Brander S, Jeffries K, Hasenbein S, He G, Denison M, et al. Changes in Menidia beryllina Gene Expression and In Vitro Hormone-Receptor Activation After Exposure to Estuarine Waters Near Treated Wastewater Outfalls. Arch Environ Contam Toxicol. 2016;71:210-23 pubmed publisher
    ..The availability of a widely geographically distributed estuarine model species (M. beryllina) now allows for improved assessment of treated effluent impacts across brackish, estuarine, and marine environments. ..
  39. Wang E, HUANG A, Huang K, McTyre E, Lo H, Watabe K, et al. Leptomeningeal failure in patients with breast cancer receiving stereotactic radiosurgery for brain metastases. J Clin Neurosci. 2017;43:6-10 pubmed publisher
    ..Neither ER/PR/HER2 status, nor prior surgery or prior WBRT predicted for development of LMF in breast patients. ..
  40. Farias A, Du X. Racial Differences in Adjuvant Endocrine Therapy Use and Discontinuation in Association with Mortality among Medicare Breast Cancer Patients by Receptor Status. Cancer Epidemiol Biomarkers Prev. 2017;26:1266-1275 pubmed publisher
    ..whether racial/ethnic differences in use and discontinuation of adjuvant endocrine therapy (AET) differed by hormone receptor status and whether discontinuation was associated with mortality...
  41. Pandey K, Kereilwe O, Kadokawa H. Heifers express G-protein coupled receptor 153 in anterior pituitary gonadotrophs in stage-dependent manner. Anim Sci J. 2018;89:60-71 pubmed publisher
    ..pituitary (AP) of heifers, leading us to speculate that GPR153 colocalizes with gonadotropin-releasing hormone receptor (GnRHR) in the plasma membrane of gonadotrophs and is expressed at specific times of the reproductive cycle...
  42. Shao X, Cai J, Zheng Y, Wang J, Feng J, Huang Y, et al. S4646 polymorphism in CYP19A1 gene is associated with the efficacy of hormone therapy in early breast cancer. Int J Clin Exp Pathol. 2015;8:5309-17 pubmed
    ..the potential association between CYP19A1 genetic polymorphisms and clinical outcome of hormone therapy in hormone receptor (HR)-positive early breast cancer...
  43. Summers K, Hume D. Identification of the macrophage-specific promoter signature in FANTOM5 mouse embryo developmental time course data. J Leukoc Biol. 2017;102:1081-1092 pubmed publisher
    ..genes, including CSF1 receptor (Csf1r), epidermal growth factor-like module-containing mucin-like hormone receptor-like 1 (Emr1), and mer receptor tyrosine kinase (Mertk), was readily detectable and increased ..
  44. Honjoh S, Ihara A, Kajiwara Y, Yamamoto T, Nishida E. The Sexual Dimorphism of Dietary Restriction Responsiveness in Caenorhabditis elegans. Cell Rep. 2017;21:3646-3652 pubmed publisher
    ..Our analysis reveals that the sex determination pathway and the steroid hormone receptor DAF-12 regulate the sex-specific DR responsiveness, integrating sex and environmental cues to determine ..
  45. Naicker M, Naidoo S. Expression of thyroid-stimulating hormone receptors and thyroglobulin in limbic regions in the adult human brain. Metab Brain Dis. 2018;33:481-489 pubmed publisher
    Expression of the human thyroid-specific proteins, thyroid-stimulating hormone receptor (TSH-R) and thyroglobulin (TG) in non-thyroid tissue is well-documented...
  46. Parissenti A, Guo B, Pritzker L, Pritzker K, Wang X, Zhu M, et al. Tumor RNA disruption predicts survival benefit from breast cancer chemotherapy. Breast Cancer Res Treat. 2015;153:135-44 pubmed publisher
    ..did not achieve a pCR were similar to that of pCR recipients across tumor subtypes, including patients with hormone receptor positive tumors that seldom achieve a pCR...
  47. Spring L, Zangardi M, Moy B, Bardia A. Clinical Management of Potential Toxicities and Drug Interactions Related to Cyclin-Dependent Kinase 4/6 Inhibitors in Breast Cancer: Practical Considerations and Recommendations. Oncologist. 2017;22:1039-1048 pubmed publisher
    ..S. Food and Drug Administration (FDA) for hormone receptor-positive metastatic breast cancer in combination with specific endocrine therapies...
  48. Li P, Chen J, Miyamoto H. Androgen Receptor Signaling in Bladder Cancer. Cancers (Basel). 2017;9: pubmed publisher
    Emerging preclinical findings have indicated that steroid hormone receptor signaling plays an important role in bladder cancer outgrowth...
  49. Rasmy A, Abozeed W, Elsamany S, Baiomy M, Nashwa A, Amrallah A, et al. Correlation of Preoperative Ki67 and Serum CA15.3 Levels with Outcome in Early Breast Cancers a Multi Institutional Study. Asian Pac J Cancer Prev. 2016;17:3595-600 pubmed
    ..Trastuzumab and hormonal treatments were added according to HER2 and hormone receptor status. Baseline serum CA15...
  50. García Vicente A, Pérez Beteta J, Pérez García V, Molina D, Jiménez Londoño G, Soriano Castrejon A, et al. Metabolic Tumor Burden Assessed by Dual Time Point [18F]FDG PET/CT in Locally Advanced Breast Cancer: Relation with Tumor Biology. Mol Imaging Biol. 2017;19:636-644 pubmed publisher
    ..001; progesterone, p = 0.031), risk-classification (p = 0.007), and grade (p = 0.036). Hormone receptor negative tumors, high-grade tumors, and high-risk phenotypes showed higher TLG values...
  51. Ashouri J, Weiss A. Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells. J Immunol. 2017;198:657-668 pubmed publisher
    ..b>Nur77 is an immediate early gene whose expression is rapidly upregulated by TCR signaling in murine T cells and human ..
  52. Zhang L, Liu W, Wang Q, Li Q, Wang H, Wang J, et al. New Drug Candidate Targeting the 4A1 Orphan Nuclear Receptor for Medullary Thyroid Cancer Therapy. Molecules. 2018;23: pubmed publisher
    ..The experimental results suggest that IMCA is a drug candidate for MTC therapy and may work by increasing the nuclear export of NR4A1 to the cytoplasm and the tumor protein 53 (p53)-sestrins-AMPK-mTOR signaling pathway. ..
  53. Clarke C, Canchola A, Moy L, Neuhausen S, Chung N, Lacey J, et al. Regular and low-dose aspirin, other non-steroidal anti-inflammatory medications and prospective risk of HER2-defined breast cancer: the California Teachers Study. Breast Cancer Res. 2017;19:52 pubmed publisher
    ..studies have addressed whether risk reduction pertains to specific breast cancer subtypes defined jointly by hormone receptor (estrogen and progesterone receptor) and human epidermal growth factor receptor 2 (HER2) expression...
  54. Baselga J, Zamagni C, Gomez P, Bermejo B, Nagai S, Melichar B, et al. RESILIENCE: Phase III Randomized, Double-Blind Trial Comparing Sorafenib With Capecitabine Versus Placebo With Capecitabine in Locally Advanced or Metastatic HER2-Negative Breast Cancer. Clin Breast Cancer. 2017;17:585-594.e4 pubmed publisher
    ..The primary end point was progression-free survival (PFS). Patients were stratified according to hormone receptor status, previous chemotherapies for metastatic breast cancer, and geographic region...
  55. Zoltan L, Farkas R, Schally A, Pozsgai E, Papp A, Bognár L, et al. Possible Predictive Markers of Response to Therapy in Esophageal Squamous Cell Cancer. Pathol Oncol Res. 2019;25:279-288 pubmed publisher
    ..Pre-treatment tumor samples were stained for proteins SOUL, Hsp 16.2, Growth Hormone-Releasing Hormone Receptor (GHRH-R) and p-Akt using immunhistochemistry methods...
  56. Hohos N, Cho K, Swindle D, Skaznik Wikiel M. High-fat diet exposure, regardless of induction of obesity, is associated with altered expression of genes critical to normal ovulatory function. Mol Cell Endocrinol. 2018;470:199-207 pubmed publisher
    ..Taken together, elevated dietary fat intake, regardless of obesity, is associated with impaired estrous cycle, depletion of the ovarian reserve, and altered expression of genes critical to normal ovulatory function. ..
  57. Roeke T, Sobral Leite M, Dekker T, Wesseling J, Smit V, Tollenaar R, et al. The prognostic value of the tumour-stroma ratio in primary operable invasive cancer of the breast: a validation study. Breast Cancer Res Treat. 2017;166:435-445 pubmed publisher
    ..35, p = 0.046, 95% confidence interval 1.01-1.81). In subgroups of hormone receptor-positive and lymph node-negative cases, high stromal content was also an independent prognosticator for worse ..
  58. Kim B, Kayembe K, Simecka J, Pulse M, Jones H. Corticotropin-releasing hormone receptor-1 and 2 activity produces divergent resistance against stress-induced pulmonary Streptococcus pneumoniae infection. J Neuroimmunol. 2011;237:57-65 pubmed publisher
    ..CRH receptor-mediated effects on immune responses could prove valuable for novel therapeutics...
  59. Clatot F, Perdrix A, Sefrioui D, Sarafan Vasseur N, Di Fiore F. [Clinical relevance of ESR1 circulating mutations detection in hormone receptor positive metastatic breast cancer]. Bull Cancer. 2018;105:46-54 pubmed publisher
    If hormone therapy is a key treatment for hormone receptor positive advanced breast cancers, secondary resistance occurs as a rule...
  60. Qing H, Jones K, Heywood E, Lu H, Daugherty A, Bruemmer D. Deletion of the NR4A nuclear receptor NOR1 in hematopoietic stem cells reduces inflammation but not abdominal aortic aneurysm formation. BMC Cardiovasc Disord. 2017;17:271 pubmed publisher
    The NR4A3 orphan nuclear hormone receptor, NOR1, functions as a constitutively active transcription factor to regulate inflammation, proliferation, and cell survival during pathological vascular remodeling...
  61. Zhou L, Ruvolo V, McQueen T, Chen W, Samudio I, Conneely O, et al. HDAC inhibition by SNDX-275 (Entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML. Leukemia. 2013;27:1358-68 pubmed publisher
    b>Nur77 and Nor1 are highly conserved orphan nuclear receptors...
  62. Zhang X, Xu J, Nakatsu C. Draft Genome Sequence of Pseudomonas fluorescens Strain TR3, a Potential Biocontrol Agent against the Rice Blast Fungus Magnaporthe oryzae. Genome Announc. 2017;5: pubmed publisher
    We present the draft genome sequence of the potential biocontrol agent Pseudomonas fluorescens TR3, which was isolated from rice leaves infected with Magnaporthe oryzae in a greenhouse...
  63. Blok E, Kroep J, Meershoek Klein Kranenbarg E, Duijm de Carpentier M, Putter H, Liefers G, et al. Relevant factors for the optimal duration of extended endocrine therapy in early breast cancer. Breast Cancer Res Treat. 2018;168:413-420 pubmed publisher
    For postmenopausal patients with hormone receptor-positive early breast cancer, the optimal subgroup and duration of extended endocrine therapy is not clear yet...
  64. Guarducci C, Bonechi M, Boccalini G, Benelli M, Risi E, Di Leo A, et al. Mechanisms of Resistance to CDK4/6 Inhibitors in Breast Cancer and Potential Biomarkers of Response. Breast Care (Basel). 2017;12:304-308 pubmed publisher
    Randomized clinical trials demonstrated that CDK4/6 inhibitors are highly effective in patients with hormone receptor-positive (HR+), HER2-negative (HER2-) metastatic breast cancer in combination with endocrine therapy...
  65. Pasing Y, Fenton C, Jorde R, Paulssen R. Changes in the human transcriptome upon vitamin D supplementation. J Steroid Biochem Mol Biol. 2017;173:93-99 pubmed publisher
    ..were particularly involved in the interleukin signaling pathway, oxidative stress response, apoptosis signaling pathway and gonadotropin releasing hormone receptor pathway. Thus, our results open the possibility for many future studies.
  66. Jimenez R, Privalsky M. A resistance to thyroid hormone syndrome mutant operates through the target gene repertoire of the wild-type thyroid hormone receptor. Mol Cell Endocrinol. 2017;447:87-97 pubmed publisher
    ..Our results highlight the importance of target gene specificity in defining the disease phenotype and improve our understanding of how clinical treatments impact RTH-Syndrome. ..
  67. Yang D, Xiao C, Su Z, Huang M, Qin M, Wu W, et al. (-)-7(S)-hydroxymatairesinol protects against tumor necrosis factor-?-mediated inflammation response in endothelial cells by blocking the MAPK/NF-?B and activating Nrf2/HO-1. Phytomedicine. 2017;32:15-23 pubmed publisher
    ..7(S)-hydroxymatairesinol (7-HMR), a naturally occurring plant lignan, possesses both antioxidant and anti-cancer properties and therefore would be ..
  68. Griguolo G, Dieci M, Giarratano T, Giorgi C, Orvieto E, Ghiotto C, et al. Beyond breast specific-Graded Prognostic Assessment in patients with brain metastases from breast cancer: treatment impact on outcome. J Neurooncol. 2017;131:369-376 pubmed publisher
    ..181 patients were identified. Tumor phenotype distribution was as follows: triple negative (TN, 18.8%), hormone receptor (HR)-HER2+ (16.6%), HR+HER2+ (23.2%) and HR+HER2- (30.9%), not available (10.5%)...
  69. Wu W, Xu Z, Ran R, Meng F, Chang K. Promyelocytic leukemia protein PML inhibits Nur77-mediated transcription through specific functional interactions. Oncogene. 2002;21:3925-33 pubmed
    ..Here, we showed that PML is a potent transcriptional repressor of Nur77, an orphan receptor and a member of the steroid receptor superfamily of proteins...
  70. Pizzuti L, Natoli C, Gamucci T, Mauri M, Sergi D, Di Lauro L, et al. Anthropometric, clinical and molecular determinants of treatment outcomes in postmenopausal, hormone receptor positive metastatic breast cancer patients treated with fulvestrant: Results from a real word setting. Oncotarget. 2017;8:69025-69037 pubmed publisher
    To characterize determinants of treatment outcome in a real world population of 161 post-menopausal hormone receptor-positive metastatic breast cancer patients treated with fulvestrant...
  71. Wang Z, Liu Q, Liao S, Yang R, Ge T, He X, et al. Expression and correlation of sodium/iodide symporter and thyroid stimulating hormone receptor in human thyroid carcinoma. Tumori. 2011;97:540-6 pubmed publisher
    To investigate the expression of sodium/iodide symporter (NIS) and thyroid stimulating hormone receptor (TSHR) in human thyroid cancer.