NUP43

Summary

Gene Symbol: NUP43
Description: nucleoporin 43kDa
Alias: bA350J20.1, p42, nucleoporin Nup43, nup107-160 subcomplex subunit Nup43
Species: human

Top Publications

  1. ncbi Adherence regulates macrophage signal transduction and primes tumor necrosis factor production
    G J Bauer
    Department of Surgery, University of Washington Medical School, Seattle, USA
    Shock 14:435-40. 2000
  2. ncbi Atypical protein kinase C-zeta stimulates thyrotropin-independent proliferation in rat thyroid cells
    N Fernandez
    Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia 19104-6160, USA
    Endocrinology 141:146-52. 2000
  3. ncbi Rapid mitogen-activated protein kinase by basic fibroblast growth factor in rat intestine after ischemia/reperfusion injury
    Xiao bing Fu
    Wound Healing and Cell Biology Laboratory, 304 Hospital, Burns Institute, Trauma Center of Postgraduate Medical College, 51 Fu Cheng Road, Beijing 100037, China
    World J Gastroenterol 9:1312-7. 2003
  4. pmc Gene transcription profile of the detached retina (An AOS Thesis)
    David N Zacks
    Kellogg Eye Center, University of Michigan, Ann Arbor
    Trans Am Ophthalmol Soc 107:343-82. 2009
  5. ncbi Comitogenic effect of catecholamines on rat cardiac fibroblasts in culture
    M Leicht
    Carl Ludwig Institute of Physiology, University of Leipzig, Liebigstr 27, D 04103, Leipzig, Germany
    Cardiovasc Res 48:274-84. 2000
  6. doi Aqueous humor outflow effects of 2-arachidonylglycerol
    Ya Fatou Njie
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Exp Eye Res 87:106-14. 2008
  7. ncbi Role of arrestins in endocytosis and signaling of alpha2-adrenergic receptor subtypes
    J L DeGraff
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 274:11253-9. 1999
  8. ncbi Participation of a stress-activated protein kinase cascade in the activation of tyrosine hydroxylase in chromaffin cells
    G Thomas
    Department of Biochemistry, University of Dundee, Scotland
    Eur J Biochem 247:1180-9. 1997
  9. ncbi 1alpha,25-dihydroxyvitamin D(3) and 24R,25-dihydroxyvitamin D(3) modulate growth plate chondrocyte physiology via protein kinase C-dependent phosphorylation of extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase
    Z Schwartz
    Department of Orthopedics, University of Texas Health Science Center, San Antonio 78229, USA
    Endocrinology 143:2775-86. 2002
  10. doi Expression of annexin-1 in equine leucocytes and the effects of the N-terminal annexin-1 peptide, Ac2-26, on equine neutrophil superoxide production
    Kirstie J Pickles
    Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Campus, Hawkshead Lane, North Mymms, Hertfordshire AL9 7TA, UK
    Vet Immunol Immunopathol 135:226-33. 2010

Detail Information

Publications193 found, 100 shown here

  1. ncbi Adherence regulates macrophage signal transduction and primes tumor necrosis factor production
    G J Bauer
    Department of Surgery, University of Washington Medical School, Seattle, USA
    Shock 14:435-40. 2000
    ..activation of MAPK was assessed by western analysis using a dual phosphospecific antibody against p38MAPK, p42,44ERK, and p54SAPK. LPS is known to induce activation of NF-kappaB and AP-1...
  2. ncbi Atypical protein kinase C-zeta stimulates thyrotropin-independent proliferation in rat thyroid cells
    N Fernandez
    Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia 19104-6160, USA
    Endocrinology 141:146-52. 2000
    ..Cells overexpressing PKCzeta show higher levels of phosphorylated p42/p44 MAPK compared with vector-transfected cells...
  3. ncbi Rapid mitogen-activated protein kinase by basic fibroblast growth factor in rat intestine after ischemia/reperfusion injury
    Xiao bing Fu
    Wound Healing and Cell Biology Laboratory, 304 Hospital, Burns Institute, Trauma Center of Postgraduate Medical College, 51 Fu Cheng Road, Beijing 100037, China
    World J Gastroenterol 9:1312-7. 2003
    ....
  4. pmc Gene transcription profile of the detached retina (An AOS Thesis)
    David N Zacks
    Kellogg Eye Center, University of Michigan, Ann Arbor
    Trans Am Ophthalmol Soc 107:343-82. 2009
    ..We also define the early activation of kinases that might be responsible for the detachment-induced changes in gene transcription...
  5. ncbi Comitogenic effect of catecholamines on rat cardiac fibroblasts in culture
    M Leicht
    Carl Ludwig Institute of Physiology, University of Leipzig, Liebigstr 27, D 04103, Leipzig, Germany
    Cardiovasc Res 48:274-84. 2000
    ..We studied the ability of norepinephrine and of other catecholamines to affect the proliferation of cardiac fibroblasts isolated from adult rat hearts. Furthermore, we investigated the possible adrenergic receptor involved in this process...
  6. doi Aqueous humor outflow effects of 2-arachidonylglycerol
    Ya Fatou Njie
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Exp Eye Res 87:106-14. 2008
    ..2-AG induced activation of p42/44 mitogen-activated protein (MAP) kinase was determined by Western blot analysis using an anti-phospho p42/44 MAP ..
  7. ncbi Role of arrestins in endocytosis and signaling of alpha2-adrenergic receptor subtypes
    J L DeGraff
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 274:11253-9. 1999
    ..in the trafficking of human alpha2-adrenergic receptors (alpha2-ARs) and the effect of receptor trafficking on p42/p44 MAP kinase activation...
  8. ncbi Participation of a stress-activated protein kinase cascade in the activation of tyrosine hydroxylase in chromaffin cells
    G Thomas
    Department of Biochemistry, University of Dundee, Scotland
    Eur J Biochem 247:1180-9. 1997
    ..Stimulation of bovine adrenal chromaffin cells with acetylcholine activated SAPK2 and MAPKAP-K2, as well as p42/p44 MAP kinases and their downstream target MAPKAP-K1...
  9. ncbi 1alpha,25-dihydroxyvitamin D(3) and 24R,25-dihydroxyvitamin D(3) modulate growth plate chondrocyte physiology via protein kinase C-dependent phosphorylation of extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase
    Z Schwartz
    Department of Orthopedics, University of Texas Health Science Center, San Antonio 78229, USA
    Endocrinology 143:2775-86. 2002
    ..In both cells the effect was due to ERK1/2 activation (p42 > p44 in GC; p42 = p44 in RC). MAPK activation was dependent on PKC, but not protein kinase A...
  10. doi Expression of annexin-1 in equine leucocytes and the effects of the N-terminal annexin-1 peptide, Ac2-26, on equine neutrophil superoxide production
    Kirstie J Pickles
    Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Campus, Hawkshead Lane, North Mymms, Hertfordshire AL9 7TA, UK
    Vet Immunol Immunopathol 135:226-33. 2010
    ..Annexin-1 expression in equine neutrophils and mononuclear cells and the ability of Ac2-26 to activate neutrophil p42/44 MAPK were determined by immunoblotting...
  11. ncbi A role for the MEK-MAPK pathway in okadaic acid-induced meiotic resumption of incompetent growing mouse oocytes
    C de Vantéry Arrighi
    Clinique de Stérilité et d Endocrinologie Gynécologique, Département de gynécologie et obstétrique, Maternité, Hopitaux Universitaires de Geneve, 1211 Geneve 14, Switzerland
    Biol Reprod 63:658-65. 2000
    ..maturation promoting factor (MPF; [p34(cdc2)/cyclin B kinase]) and mitogen-activated protein (MAP) kinases (p42(MAPK) and p44(MAPK)), are implicated in meiotic competence acquisition...
  12. ncbi Nitric oxide modulates stretch activation of mitogen-activated protein kinases in mesangial cells
    A J Ingram
    Department of Medicine, McMaster University Hamilton, and University of Toronto, Ontario, Canada
    Kidney Int 58:1067-77. 2000
    ..We have shown activation of Jun N-terminal kinase/stress-activated protein kinase (SAPK) and p42/44 mitogen-activated protein kinase (MAPK) in stretched MCs and have also demonstrated that L-arginine decreases ..
  13. pmc Fibroblast growth factor-2 binds to small heparin-derived oligosaccharides and stimulates a sustained phosphorylation of p42/44 mitogen-activated protein kinase and proliferation of rat mammary fibroblasts
    Maryse Delehedde
    School of Biological Sciences, Life Science Building, University of Liverpool, Crown Street, Liverpool L69 7ZB, U K
    Biochem J 366:235-44. 2002
    ..of disaccharides did not stimulate DNA synthesis and it only elicited an early transient dual phosphorylation of p42/44 mitogen-activated protein kinase (MAPK)...
  14. pmc Reduction of experimental diabetic vascular leakage by delivery of angiostatin with a recombinant adeno-associated virus vector
    Mong Ping Shyong
    Institute of Clinical Medicine, National Yang Ming University, Taipei and Su Ao Veterans Hospital, I Lan, Taiwan
    Mol Vis 13:133-41. 2007
    ..To evaluate the efficacy of recombinant adeno-associated virus (rAAV) vector expressing mouse angiostatin (Kringle domains 1 to 4) in reducing retinal vascular leakage in an experimental diabetic rat model...
  15. pmc Effect of protein kinase C and Ca(2+) on p42/p44 MAPK, Pyk2, and Src activation in rat conjunctival goblet cells
    Robin R Hodges
    Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Exp Eye Res 85:836-44. 2007
    ..Transactivation of the EGF receptor activates a kinase cascade culminating in the activation of p42/p44 MAPK (MAPK) and ultimately that leads to secretion of high molecular weight glycocongujates (HMWGC), including ..
  16. ncbi Roles of protein kinase C, Ca2+, Pyk2, and c-Src in agonist activation of rat lacrimal gland p42/p44 MAPK
    Robin R Hodges
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 47:3352-9. 2006
    Although p42/p44 mitogen-activated protein kinase (MAPK) negatively modulates protein secretion stimulated by cholinergic and alpha(1D)-adrenergic agonists, it does not play a role in epidermal growth factor (EGF)-stimulated protein ..
  17. ncbi AICAR positively regulate glycogen synthase activity and LDL receptor expression through Raf-1/MEK/p42/44MAPK/p90RSK/GSK-3 signaling cascade
    Hsiang Ming Wang
    Department of Molecular and Cellular Biochemistry, The Dorothy M Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, 464 Hamilton Hall, Columbus, OH 43210, United States
    Biochem Pharmacol 75:457-67. 2008
    ..The signal connection between AICAR and GSK-3 is indirect and involves activation of Raf-1/MEK/p42/44(MAPK)/p90(RSK) signaling cascade as pharmacologic inhibition of MEK significantly reduced phosphorylation/..
  18. doi Bradykinin and high glucose promote renal tubular inflammation
    Sydney C W Tang
    Division of Nephrology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Nephrol Dial Transplant 25:698-710. 2010
    ..The role of the kallikrein-kinin system in diabetic nephropathy remains controversial...
  19. ncbi Modulations of signal transduction pathways during sepsis and the effects of insulin and mifepristone
    Subir R Maitra
    Department of Emergency Medicine, Stony Brook University Hospital, NY 11794, USA
    Acad Emerg Med 10:1-8. 2003
    ..states and the inferred activation of specific members of the mitogen-activated protein kinase (MAPK) pathways (p42/44, p38, and SAPK/JNK) were quantitated in the livers of rats by Western blot analysis during the progression of ..
  20. ncbi p38 and JNK have distinct regulatory functions on the development of apoptosis during simulated ischaemia and reperfusion in neonatal cardiomyocytes
    A M Engelbrecht
    Department of Physiological Sciences, University of Stellenbosch, Tygerberg, Republic of South Africa
    Basic Res Cardiol 99:338-50. 2004
    ..strong, biphasic activation of p38 concomitant with a weak and transient activation of the two ERK isoenzymes, p42/p44-MAPK...
  21. ncbi Dual regulation of tumor necrosis factor-alpha-induced CCL2/monocyte chemoattractant protein-1 expression in vascular smooth muscle cells by nuclear factor-kappaB and activator protein-1: modulation by type III phosphodiesterase inhibition
    Yung Ming Chen
    Department of Medicine, National Taiwan University Hospital, 7, Chung Shan South Rd, Taipei, 10016, Taiwan
    J Pharmacol Exp Ther 309:978-86. 2004
    ..PD98059), 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio) butadiene (U0126) [both inhibitors of p42/44 mitogen-activated protein kinase (MAPK) kinase], and anthra[1hyphen]9-cd]pyrazol-6(2H)-one (SP600125) [an ..
  22. doi Hypothetical mechanism of sodium pump regulation by estradiol under primary hypertension
    Emina Sudar
    Laboratory for Molecular Genetics and Radiobiology, Institute Vinca, P O Box 522, 11001 Belgrade, Serbia
    J Theor Biol 251:584-92. 2008
    ..involve the activation of multiple signaling cascades, including phosphatydil inositol-3 kinase (PI3K) and p42/44 mitogen-activated protein kinase (p42/44(MAPK))...
  23. ncbi Role of caveolin-1 in p42/p44 MAP kinase activation and proliferation of human airway smooth muscle
    Reinoud Gosens
    Department of Physiology, University of Manitoba, Winnipeg, Canada
    Am J Physiol Lung Cell Mol Physiol 291:L523-34. 2006
    ..Therefore, we investigated their role in p42/p44 MAPK signaling and proliferation using human ASM cell lines...
  24. doi Transient protective effect of caspase inhibitors in RCS rat
    O Perche
    Univ Clermont 1, UFR Pharmacie, Laboratoire de Biophysique Sensorielle, EA 2667, Clermont Ferrand, France
    Exp Eye Res 86:519-27. 2008
    ..Retinal status was evaluated at P35 and P42 by electroretinography, morphometry and apoptotic nuclei detection...
  25. ncbi CB2 cannabinoid receptors in trabecular meshwork cells mediate JWH015-induced enhancement of aqueous humor outflow facility
    Lichun Zhong
    Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, KY 40292, USA
    Invest Ophthalmol Vis Sci 46:1988-92. 2005
    ....
  26. ncbi Cell cycle related signaling in Neuro2a cells proceeds via the receptor for advanced glycation end products
    A Schmidt
    Department of Neuroanatomy, Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany
    J Neural Transm 114:1413-24. 2007
    ..S100B and AGEs may interact with the multiligand receptor for AGEs (RAGE) and trigger for the activation of the p42/44 mitogen-activated protein kinase (p42/44 MAPK), whether they also count for cell cycle related signaling in ..
  27. pmc Human T- and B-cell responses to Schistosoma mansoni recombinant glyceraldehyde 3-phosphate dehydrogenase correlate with resistance to reinfection with S. mansoni or Schistosoma haematobium after chemotherapy
    R El Ridi
    Zoology Department, Faculty of Science, Cairo University, Cairo, Egypt
    Infect Immun 69:237-44. 2001
    Recently we reported that human T- and B-cell recognition of a 42-kDa protein (p42) in soluble extracts of adult Schistosoma mansoni worms correlates with resistance to reinfection with S. mansoni or S. haematobium...
  28. ncbi Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor
    Yasunari Takada
    Cytokine Research Laboratory, Department of Bioimmunotherapy, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 279:39541-54. 2004
    ..Deletion of GSK-3beta also abolished TNF-induced c-Jun N-terminal kinase and p44/p42 mitogen-activated kinase activation...
  29. ncbi Dihydropyridine and beta adrenergic receptor binding in dogs with tachycardia-induced atrial fibrillation
    R Gaspo
    Department of Medicine, Montreal Heart Institute, Quebec, Canada
    Cardiovasc Res 42:434-42. 1999
    ..The present study was designed to determine whether atrial tachycardia alters biochemical indices of the number of L-type Ca2+ channels and/or of the number and binding affinity of beta-adrenergic receptors...
  30. ncbi Ligand-independent activation of steroid receptors
    A P F Flint
    School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leics LE12 5RD, UK
    Domest Anim Endocrinol 23:13-24. 2002
    ..added at various times following transfection, and MAP kinase phosphorylation was monitored by western blotting of p42 and p44...
  31. ncbi Activation of mitogen-activated protein kinase by oxidized low-density lipoprotein in canine cultured vascular smooth muscle cells
    C M Yang
    Cellular and Molecular Pharmacology Laboratory, Department of Pharmacology, College of Medicine, Chang Gung University, Kwei San, Taiwan
    Cell Signal 12:205-14. 2000
    ..associated with a specific pattern of mitogen-activated protein kinase (MAPK) by [3H]thymidine incorporation and p42/p44 MAPK phosphorylation in canine cultured VSMCs...
  32. doi A biotin-coupled bifunctional enzyme exhibiting both glutamine synthetase activity and glutamate decarboxylase activity
    Khomkrit Arunchaipong
    Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
    Curr Eye Res 34:809-18. 2009
    To purify and study native form and enzymatic activity of the 42 kDa biotin-coupled protein (p42), which is related to glutamate action in chick retina.
  33. ncbi Tumor necrosis factor-alpha stimulates fractalkine production by mesangial cells and regulates monocyte transmigration: down-regulation by cAMP
    Yung Ming Chen
    Department of Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Kidney Int 63:474-86. 2003
    ..We investigated the mechanisms by which tumor necrosis factor (TNF)-alpha stimulates mesangial cell (MC) fractalkine expression, and the effects of MC-derived fractalkine on monocyte transmigration...
  34. ncbi Inhibition of IL-8-mediated MAPK activation in human neutrophils by beta1 integrin ligands
    Demetra Xythalis
    Center for Cell Biology and Cancer Research, Albany Medical College, NY 12208, USA
    Inflammation 26:83-8. 2002
    ..leads to the activation of heterotrimeric G proteins that initiate multiple signaling cascades, including p38 and p42/p44 mitogen-activated protein kinase (MAPK) pathways...
  35. pmc Ontogeny of acute tolerance to ethanol-induced social inhibition in Sprague-Dawley rats
    Elena I Varlinskaya
    Center for Developmental Psychobiology, Department of Psychology, Binghamton University, Binghamton, NY 13902, USA
    Alcohol Clin Exp Res 30:1833-44. 2006
    ..The present study explored ontogenetic development of acute tolerance within 30 minutes after administration of a relatively low ethanol dose, using ethanol-induced social impairment as the target response measure...
  36. pmc Confluence of vascular endothelial cells induces cell cycle exit by inhibiting p42/p44 mitogen-activated protein kinase activity
    F Vinals
    Centre de Biochimie CNRS UMR 6543, Universite de Nice, 06108 Nice, France
    Mol Cell Biol 19:2763-72. 1999
    ..In this work, we have studied the effect of cellular contact on the activation of p42/p44 mitogen-activated protein kinase (MAPK) by growth factors in mouse vascular endothelial cells...
  37. pmc Tyrosine phosphorylation and activation of homologous protein kinases during oocyte maturation and mitogenic activation of fibroblasts
    J Posada
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Mol Cell Biol 11:2517-28. 1991
    ..Two tyrosine-phosphorylated 42-kDa proteins (p42) were detected with this antiserum in Xenopus eggs...
  38. ncbi D-glucose stimulation of L-arginine transport and nitric oxide synthesis results from activation of mitogen-activated protein kinases p42/44 and Smad2 requiring functional type II TGF-beta receptors in human umbilical vein endothelium
    Rodrigo Vásquez
    Cellular and Molecular Physiology Laboratory, Department of Obstetrics and Gynaecology, Medical Research Centre, School of Medicine, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Cell Physiol 212:626-32. 2007
    ..via TGF-beta receptors I (TbetaRI) and TbetaRII, activates Smad2 and mitogen-activated protein kinases p44 and p42 (p42/44(mapk))...
  39. pmc Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice
    K L Auer
    Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Biochem J 336:551-60. 1998
    In primary rat hepatocytes, prolonged activation of the p42/44 mitogen-activated protein kinase (MAPK) pathway is associated with a decrease in DNA synthesis and increased expression of the cyclin-dependent kinase inhibitor (CKI) ..
  40. ncbi Actinobacillus actinomycetemcomitans lipopolysaccharide stimulates the phosphorylation of p44 and p42 MAP kinases through CD14 and TLR-4 receptor activation in human gingival fibroblasts
    Gloria Gutiérrez-Venegas
    Laboratorio de Bioquímica División de Estudios de Posgrado Facultad de Odontología Universidad, Nacional Autónoma de México México, D F 04510
    Life Sci 78:2577-83. 2006
    ..the tyrosine kinase inhibitors, herbimycin A and genistein inhibited the LPS-stimulated phosphorylation of p44 and p42 MAP kinases in a dose dependent manner...
  41. ncbi Role of mitogen-activated protein kinases and protein kinase C in regulating low-density lipoprotein receptor expression
    Kamal D Mehta
    Department of Molecular and Cellular Biochemistry, Ohio State University College of Medicine and Public Health, Columbus 43210, USA
    Gene Expr 10:153-64. 2002
    ..growth factors, anisomycin, and phorbol esters involves the extracellular/mitogen-activated protein kinase (p42/44MAPK) cascade. In fact, degree of p42/44MAPK activation determines the extent of LDL receptor induction...
  42. ncbi Lipoxin A4 inhibits connective tissue growth factor-induced production of chemokines in rat mesangial cells
    S H Wu
    Department of Pediatrics, Central Laboratory, The First Affiliated Hospital of Nanjing Medical University, Jiangsu, People s Republic of China
    Kidney Int 69:248-56. 2006
    ..enhanced the mRNA expression and protein release of fractalkine, MCP-1, and RANTES, the expression of phospho (P)-p42/44 mitogen-activated protein kinase (MAPK), P-phosphoinositide 3-kinase (PI3-K), P-Akt, and activity of nuclear ..
  43. ncbi Oligomerization controls in tissue-specific manner ligand binding of native, affinity-purified p42(IP4)/centaurin alpha1 and cytohesins-proteins with high affinity for the messengers D-inositol 1,3,4,5-tetrakisphosphate/phosphatidylinositol 3,4,5-trisphos
    Rolf Stricker
    Institut fur Neurobiochemie, Medizinische Fakultät der Otto von Guericke Universität Magdeburg, 39120 Magdeburg, Germany
    Biochim Biophys Acta 1651:102-15. 2003
    ..for the second messengers Ins(1,3,4,5)P(4) and PtdIns(3,4,5)P(3) are already known, such as the brain-specific p42(IP4), which we have previously cloned from different species, and cytohesins...
  44. ncbi Interleukin-1beta induces MMP-9 expression via p42/p44 MAPK, p38 MAPK, JNK, and nuclear factor-kappaB signaling pathways in human tracheal smooth muscle cells
    Kao Chih Liang
    Department of Physiology and Pharmacology, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    J Cell Physiol 211:759-70. 2007
    ..Here, we investigated the roles of p42/p44 MAPK, p38 MAPK, JNK, and NF-kappaB pathways for IL-1beta-induced MMP-9 production in HTSMCs...
  45. ncbi Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons
    H G Bernstein
    Department of Psychiatry, Medical Faculty of University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Neuroscience 146:1513-23. 2007
    ..Previously, we have detected that nardilysin interacts with brain-specific proteins, i.e. p42(IP4)/centaurin-alpha1 [Stricker R, Chow KM, Walther D, Hanck T, Hersh LB, Reiser G (2006) Interaction of the brain ..
  46. ncbi Inhibitory effect of antisense oligodeoxynucleotide to p44/p42 MAPK on angiotensin II-induced hypertrophic response in cultured neonatal rat cardiac myocyte
    Shi Qin Zhang
    Laboratory of Molecular Pharmacology, Xiang Ya School of Medicine, Central South University, Changsha 410078, China
    Acta Pharmacol Sin 25:41-6. 2004
    ..To explore the inhibitory effect of antisense oligonucleotide (ODN) to mitogen activated protein kinase(MAPK) on cardiomyocyte hypertrophy induced by angiotensin II (Ang II)...
  47. pmc Leukotriene B(4) BLT receptor signaling regulates the level and stability of cyclooxygenase-2 (COX-2) mRNA through restricted activation of Ras/Raf/ERK/p42 AUF1 pathway
    Beibei Zhai
    Department of Medicine, McGill University, Montreal, Quebec H3A 1A1
    J Biol Chem 285:23568-80. 2010
    ..RNAs confirmed that LTB(4) stabilization of COX-2 mRNA was apparently mediated through the RNA-binding protein, p42 AUF1...
  48. ncbi Identification, purification, and characterization of a PA700-dependent activator of the proteasome
    G N DeMartino
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Biol Chem 271:3112-8. 1996
    ..and is composed of three electrophoretically distinct subunits with Mr values of 50,000, 42,000, and 27,000 (p50, p42, and p27, respectively)...
  49. pmc Cloning and characterization of the p42 subunit of mammalian translation initiation factor 3 (eIF3): demonstration that eIF3 interacts with eIF5 in mammalian cells
    A Bandyopadhyay
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine of Yeshiva University, Jack and Pearl Resnick Campus, Bronx, New York, NY 10461, USA
    Nucleic Acids Res 27:1331-7. 1999
    ..cDNAs encoding all the subunits of mammalian eIF3 except the p42 subunit have been cloned in several laboratories...
  50. ncbi Chlamydophila pneumoniae induces p44/p42 mitogen-activated protein kinase activation in human fibroblasts through Toll-like receptor 4
    Iana H Haralambieva
    Department of Microbiology, Medical University, Zdrave 2 str, 1431 Sofia, Bulgaria
    J Med Microbiol 53:1187-93. 2004
    ..C. pneumoniae elementary bodies were demonstrated to up-regulate the phosphorylation of p44/p42 mitogen-activated protein kinase (MAPK) in human fibroblasts...
  51. ncbi Protein kinase C zeta plays a central role in activation of the p42/44 mitogen-activated protein kinase by endotoxin in alveolar macrophages
    M M Monick
    Department of Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, IA, USA
    J Immunol 165:4632-9. 2000
    ..respond to endotoxin (LPS) by activation of a number of mitogen-activated protein kinase pathways, including the p42/44 (extracellular signal-related kinase (ERK)) kinase pathway...
  52. ncbi The growth-promoting effect of low-density lipoprotein may Be mediated by a pertussis toxin-sensitive mitogen-activated protein kinase pathway
    A Sachinidis
    Medizinische Universitäts Poliklinik, 53111 Bonn, Germany
    Mol Pharmacol 52:389-97. 1997
    ..PTX)-sensitive stimulation of the 44-kDa mitogen-activated protein (MAP) kinase (p44(mapk)) and 42-kDa MAP kinase (p42(mapk)) isoforms as well as in a PTX-sensitive increase in intracellular free Ca2+ concentration ([Ca2+]i)...
  53. doi Enterovirus 71 modulates a COX-2/PGE2/cAMP-dependent viral replication in human neuroblastoma cells: role of the c-Src/EGFR/p42/p44 MAPK/CREB signaling pathway
    Wei Hsuan Tung
    Department of Physiology and Pharmacology, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    J Cell Biochem 112:559-70. 2011
    ..We also observed that EV71-induced p42/p44 MAPK phosphorylation was decreased following pretreatment with AG1478...
  54. ncbi Cyclooxygenase-2 induction by lysophosphatidylcholine in cultured rat vascular smooth muscle cells: involvement of the p38MAPK pathway
    Tadashi Yamakawa
    Department of Endocrinology and Diabetes, Yokohama City University Medical Center, Yokohoma, Japan
    Biomed Res 29:1-8. 2008
    ..MAPK) inhibitor SB203580 significantly suppressed lysoPC-induced COX-2 mRNA and protein expression, but not a p42/44MAPK kinase (MEK-1) inhibitor, PD98059...
  55. pmc C1q/tumor necrosis factor-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis
    Zhikui Wei
    Department of Physiology and Center for Metabolism and Obesity Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 288:10214-29. 2013
    ..Impaired adipogenesis was caused by a CTRP11-mediated decrease in p42/44-MAPK signaling and inhibition of mitotic clonal expansion, a process essential for adipocyte differentiation in ..
  56. ncbi Overproduction of VEGF concomitantly expressed with its receptors promotes growth and survival of melanoma cells through MAPK and PI3K signaling
    Jordi Graells
    Department of Dermatology, Ciutat Sanitaria i Universitaria de Bellvitge, Barcelona, Spain
    J Invest Dermatol 123:1151-61. 2004
    ..DNA synthesis to 20% with respect to the controls, although they did not completely suppress either the p44 or p42-phosphorylated forms of extracellular signal-regulated protein kinase...
  57. ncbi Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-activated primary rat microglia
    Ravi Shankar Akundi
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    Glia 51:199-208. 2005
    ..to the release of ceramides, which in turn, activate the p38 mitogen-activated protein kinases (MAPK), but not the p42/44 MAPK...
  58. pmc Phosphorylation of recombinant tristetraprolin in vitro
    Heping Cao
    Diet, Genomics and Immunology Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, MD 20705, USA
    Protein J 27:163-9. 2008
    ..SDS-PAGE showed that in vitro phosphorylation of TTP with p42 and p38 MAP kinases resulted in visible electrophoretic mobility shift of TTP to higher molecular masses...
  59. ncbi Low-density lipoprotein inhibits secretion of phospholipid transfer protein in human trophoblastic BeWo cells
    An Yue Tu
    Department of Medicine, Northwest Lipid Research Laboratories, Northwest Lipid Research Clinic, Division of Metabolism, Endocrinology, and Nutrition, University of Washington, 2121 N 35th Street, Seattle, WA 98103, USA
    Exp Biol Med (Maywood) 229:1046-52. 2004
    ..could stimulate the expression of MAPK phosphatase-1 (MKP-1) in BeWo cells that resulted in the inactivation of p44/p42 extracellular signal-regulated kinase (ERK) 1 and 2, the family members of MAPKs...
  60. ncbi R(+)-methanandamide-induced cyclooxygenase-2 expression in H4 human neuroglioma cells: possible involvement of membrane lipid rafts
    Burkhard Hinz
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    Biochem Biophys Res Commun 324:621-6. 2004
    ..was recently shown to involve increased synthesis of ceramide, which in turn leads to activation of p38 and p42/44 mitogen-activated protein kinases (MAPKs)...
  61. ncbi PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning
    Mihaela M Mocanu
    The Hatter Institute for Cardiovascular Studies, University College London Hospital and Medical School, London, UK
    J Mol Cell Cardiol 34:661-8. 2002
    ..putative anti-apoptotic pathways, through the induction of either phosphatidyl inositol 3-OH kinase (PI3 kinase) or p42/p44 extracellular receptor kinase, attenuating total cell death...
  62. ncbi Role of MAPK phosphatase-1 (MKP-1) in adipocyte differentiation
    Hiroshi Sakaue
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    J Biol Chem 279:39951-7. 2004
    ..We have now shown that the activity, but not the abundance, of p42/p44 mitogen-activated protein kinase (MAPK) is down-regulated during adipocyte differentiation...
  63. pmc The novel human β-defensin 114 regulates lipopolysaccharide (LPS)-mediated inflammation and protects sperm from motility loss
    Heguo Yu
    National Population and Family Planning Commission Key Laboratory of Contraceptives and Devices, Shanghai Institute of Planned Parenthood Research, Shanghai 200032, China
    J Biol Chem 288:12270-82. 2013
    ..7 cultures through the inhibition of MAPK p42/44 when challenged with LPS...
  64. doi Rho-kinase limits BMP-4-stimulated osteocalcin synthesis in osteoblasts: regulation of the p38 MAP kinase pathway
    Akira Kondo
    Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    Life Sci 96:18-25. 2014
    ..of osteocalcin via p38 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells, whereas p44/p42 MAP kinase plays as a negative regulator in the synthesis...
  65. ncbi Gene regulation in an MCF-7 cell line that naturally expresses an estrogen receptor unable to directly bind DNA
    Brian T Pentecost
    Wadsworth Center, NY State DoH, P O Box 509, Albany, NY 12201 0509, USA
    Mol Cell Endocrinol 238:9-25. 2005
    ..This was blocked by inhibitors of the p42/44 mitogen activated protein (MAP) kinase and inositol triphosphate (PI3) kinase pathways suggesting a role for ..
  66. pmc Abnormal expression of the pre-mRNA splicing regulators SRSF1, SRSF2, SRPK1 and SRPK2 in non small cell lung carcinoma
    Stéphanie Gout
    Equipe 2 Bases Moléculaires de la Progression des Cancers du Poumon, INSERM, U823, Grenoble, France
    PLoS ONE 7:e46539. 2012
    ..demonstrate that SRSF1 overexpression leads to a more invasive phenotype, evidenced by activation of PI3K/AKT and p42/44MAPK signaling pathways, increased growth capacity in soft agar, acquisition of mesenchymal markers such as E ..
  67. doi Effect of OPC-12759 on EGF receptor activation, p44/p42 MAPK activity, and secretion in conjunctival goblet cells
    J David Rios
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Exp Eye Res 86:629-36. 2008
    ..stimulates secretion from conjunctival goblet cells in culture and if it activates the EGF receptor (EGFR) and p44/p42 mitogen-activated protein kinase (MAPK) to cause mucin secretion...
  68. ncbi Association of axon guidance factor semaphorin 3A with poor outcome in pancreatic cancer
    Michael W Müller
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 121:2421-33. 2007
    ..and invasiveness of pancreatic cancer cells through activation of multiple pathways involving Rac1, GSK3b or p42/p44 MAPK, but not E- to N-cadherin switch, MMP-9 or VEGF induction...
  69. doi (-)-Epigallocatechin gallate inhibits basic fibroblast growth factor-stimulated interleukin-6 synthesis in osteoblasts
    H Tokuda
    Department of Clinical Laboratory, National Hospital for Geriatric Medicine, National Center for Geriatrics and Gerontology, Obu, Japan
    Horm Metab Res 40:674-8. 2008
    ..EGCG attenuated the FGF-2-induced phosphorylation of p44/p42 MAP kinase and p38 MAP kinase...
  70. pmc Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells
    Jane J Yu
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 106:2635-40. 2009
    ..E(2)-induced metastasis is associated with activation of p42/44 MAPK and is completely inhibited by treatment with the MEK1/2 inhibitor, CI-1040...
  71. doi Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells
    Steffen E Schnitzer
    Faculty of Medicine, Institute of Biochemistry I ZAFES, Goethe University, Frankfurt am Main, Germany
    Mol Cancer Res 7:393-401. 2009
    ..with VPC23019, a S1P(1)/S1P(3) antagonist, reduced protection of conditioned medium, with the further notion that p42/44 mitogen-activated protein kinase transmits autocrine or paracrine survival signaling downstream of S1P(1)/S1P(3) ..
  72. doi Signal transduction of the CB1 cannabinoid receptor
    Gabor Turu
    Department of Physiology, Faculty of Medicine, Semmelweis University, PO Box 259, H 1444 Budapest, Hungary
    J Mol Endocrinol 44:75-85. 2010
    ..of CB(1)R also leads to phosphorylation and activation of mitogen-activated protein kinases (MAPK), such as p42/p44 MAPK, p38 MAPK and c-Jun N-terminal kinase, which can regulate nuclear transcription factors...
  73. doi Developmental changes of melatonin receptor expression in the spleen of the chicken, Gallus domesticus
    Qingyun Guo
    Laboratory of Veterinary Anatomy, College of Veterinary Medicine, China Agricultural University, Haidian, Beijing 100193, China
    Acta Histochem . 2015
    ..The plasma melatonin concentration increased in an age-dependent manner in the chicken from P0 to P42 (P<0.05), and this increasing change was linear after P14 (P<0.05)...
  74. doi CXCL10 contributes to p38-mediated apoptosis in primary T lymphocytes in vitro
    Abubaker M E Sidahmed
    Division of Experimental Therapeutics, Toronto General Research Institute, Toronto, Ontario, Canada
    Cytokine 59:433-41. 2012
    ..On the other hand, the transient activation of p44/p42 ERK did not have an impact on T lymphocyte survival...
  75. pmc Ultraviolet A regulates adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells via up-regulation of Kruppel-like factor 2
    Jongsung Lee
    Biospectrum Life Science Institute, Seongnam si, Gyunggi Do 462 807, Republic of Korea
    J Biol Chem 285:32647-56. 2010
    ..inhibitory factor (MIF) gene expression, and this was mediated through activation of AP-1 (especially JNK and p42/44 MAPK) and nuclear factor-κB...
  76. doi Okadaic acid-sensitive phosphatase is related to MII/G1 transition in mouse oocytes
    Naoko Moride
    Department of Obstetrics and Gynecology, University of Tokushima, Institute for Health Biosciences, 3 18 15 Kuramoto Tokushima 770 8503, Japan
    Zygote 20:193-8. 2012
    ..Histone H1 kinase and myelin basic protein (MBP) kinase activities were measured as indicators of MPF and p42 MAPK activities after insemination...
  77. pmc The progesterone-induced enhancement of object recognition memory consolidation involves activation of the extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin (mTOR) pathways in the dorsal hippocampus
    Patrick T Orr
    Department of Psychology, Yale University, New Haven, CT 06520, USA
    Horm Behav 61:487-95. 2012
    ..mice, we found that bilateral dorsal hippocampal infusion of P significantly increased levels of phospho-p42 ERK and the mTOR substrate S6K in the dorsal hippocampus 5 min after infusion...
  78. ncbi Modulation of tumor necrosis factor-alpha and oxidative stress through protein kinase C and P42/44 mitogen-activated protein kinase in lead increases lipopolysaccharide-induced liver damage in rats
    Yu Jung Cheng
    Department of Environmental and Occupational Health, and Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan 70428
    Shock 24:188-93. 2005
    ..In this study, we investigated the role of protein kinase C (PKC) and p42/44 mitogen-activated protein kinase (MAPK) and the causal relationships between TNF-alpha, NO, and LPO in Pb-..
  79. pmc Tissue kallikrein mediates pro-inflammatory pathways and activation of protease-activated receptor-4 in proximal tubular epithelial cells
    Wai Han Yiu
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    PLoS ONE 9:e88894. 2014
    ..Recombinant KLK1 stimulated the production of inflammatory cytokines in PTEC via the activation of p42/44 and p38 MAPK signaling pathways...
  80. ncbi Hydrogen peroxide stimulates extracellular signal-regulated protein kinases in pulmonary arterial smooth muscle cells
    J Zhang
    Department of Physiology and Biophysics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Respir Cell Mol Biol 19:324-32. 1998
    ..Activation of p44 and p42 extracellular signal-regulated protein kinases (ERK1 and ERK2) is an important step in the cascade leading to cell ..
  81. ncbi Beta2-adrenoceptor agonist suppresses tumour necrosis factor production in rat mesangial cells
    A Nakamura
    Department of Paediatrics, Teikyo University School of Medicine, Tokyo, Japan
    Cytokine 12:491-4. 2000
    ..protein release as well as transcription and translation of TNF-alpha and mitogen activated protein kinase (MAPK, p42/p44) activity. At 3 h, terbutaline enhanced intracellular cAMP but suppressed TNF-alpha release and transcription...
  82. ncbi The emergence of a C/EBPalpha mutation in the clonal evolution of MDS towards secondary AML
    A Kaeferstein
    Division of Hematology Oncology, Medizinische Hochschule Hannover, Germany
    Leukemia 17:343-9. 2003
    ..isoform p30, which was previously shown to inhibit the DNA-binding and transactivation properties of C/EBPalpha p42. Interestingly this mutation could not be detected at diagnosis in the initial RAEB and RAEB-T stage...
  83. ncbi Possible involvement of p21/waf1 in the growth inhibition of HepG2 cells induced by hepatocyte growth factor
    N Shima
    Research Institute of Life Science, Snow Brand Milk Products, CO, Ltd, Tochigi, Japan
    J Cell Physiol 177:130-6. 1998
    ..Phosphorylation of p42/mitogen-activated protein (MAP) kinase was observed within 10 min after HGF stimulation in both cell lines...
  84. ncbi Role of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinase kinase in adenosine A2B receptor-mediated interleukin-8 production in human mast cells
    I Feoktistov
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232 6300, USA
    Mol Pharmacol 55:726-34. 1999
    ..of HMC-1 with the stable adenosine analog NECA (5'-N-ethylcarboxamidoadenosine) activated p21(ras) and both p42 and p44 isoforms of extracellular signal-regulated kinase (ERK). NECA (10 microM) induced a 1.9 +/- 0...
  85. ncbi Isolation of the human genes encoding the pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases
    S Dowd
    ICRF Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital, Dundee DD1 9SY, Scotland, UK
    J Cell Sci 111:3389-99. 1998
    ..In common with Pyst1, Pyst2 shows substrate selectivity for the classical p42 (ERK2) isoform of MAP kinase both in vitro and in vivo, displaying much reduced activity towards stress activated ..
  86. ncbi Integrin and cytoskeletal regulation of growth factor signaling to the MAP kinase pathway
    A E Aplin
    Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Sci 112:695-706. 1999
    ..fibroblasts to the extracellular matrix component fibronectin permits efficient growth factor signaling to the p42 and p44 forms of mitogen-activated protein kinase (MAPK)...
  87. ncbi Activation of p38 MAP-kinase and caldesmon phosphorylation are essential for urokinase-induced human smooth muscle cell migration
    Elena A Goncharova
    Laboratory of Cell Motility, Institute of Experimental Cardiology, Russian Cardiology Research Center, Moscow
    Biol Chem 383:115-26. 2002
    ..that protease activity, growth factor-like and kringle domains of uPA differentially contribute to activation of p42/p44erk1,2 and p38 MAP-kinases. Consistent with our earlier data [Mukhina et al., J. Biol. Chem...
  88. ncbi The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells
    W M Macfarlane
    Department of Molecular and Cell Biology, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    J Biol Chem 272:20936-44. 1997
    ..SAPK2 could not be replaced by p42 MAP kinase, MAPKAP kinase-2, or MAPKAP kinase-3...
  89. pmc Activation of p42 mitogen-activated protein kinase (MAPK), but not c-Jun NH(2)-terminal kinase, induces phosphorylation and stabilization of MAPK phosphatase XCL100 in Xenopus oocytes
    Michael L Sohaskey
    Department of Molecular Pharmacology and Program in Cancer Biology, Stanford University School of Medicine, Stanford, California 94305 5174, USA
    Mol Biol Cell 13:454-68. 2002
    ..Epitope-tagged XCL100 was phosphorylated on serine during G2 phase, and on serine and threonine in a p42 MAPK-dependent manner during M phase. Threonine phosphorylation mapped to a single residue, threonine 168...
  90. ncbi Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction
    Elizabeth K Brint
    Cytokine Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Biol Chem 277:49205-11. 2002
    ..protein-1 (AP-1), increase phosphorylation of c-Jun, and activate the MAP kinases c-Jun N-terminal kinase (JNK), p42/p44 and p38. Anti-T1/ST2 also induces the selective expression of IL-4 but not IFN-gamma in naive T cells...
  91. ncbi Three-dimensional structure of halorhodopsin at 7 A resolution
    W A Havelka
    Max Planck Institut fur Biochemie, Martinsried, Germany
    J Mol Biol 247:726-38. 1995
    ..The three-dimensional structure (space group p42(1)2, a = 102 A) has been analysed by electron cryo-microscopy of tilted specimens...
  92. ncbi Drm/Gremlin transcriptionally activates p21(Cip1) via a novel mechanism and inhibits neoplastic transformation
    Bo Chen
    Basic Research Laboratory, National Cancer Institute at Frederick, Bldg 469, rm 102, Frederick, MD 21702 1201, USA
    Biochem Biophys Res Commun 295:1135-41. 2002
    ..Drm overexpression in these cells increases the level of p21(Cip1) protein and reduces the level of phosphorylated p42/44 MAP kinase...
  93. ncbi DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase
    D W McVicar
    Laboratory of Experimental Immunology, Division of Basic Sciences, NCI, National Institutes of Health, Maryland 21702, USA
    J Biol Chem 273:32934-42. 1998
    ..Ly49D results in 1) tyrosine phosphorylation of several substrates, including phospholipase Cgamma1, Cbl, and p44/p42 mitogen-activated protein kinase, and 2) calcium mobilization...
  94. ncbi Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors
    Susan Pyne
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Scotland, Glasgow, UK
    Biochim Biophys Acta 1582:121-31. 2002
    ..This tethered receptor complex enables coincident integrative signalling to p42/p44 MAPK...
  95. ncbi Induction and regulation of Fas-mediated apoptosis in human thyroid epithelial cells
    Emese Mezosi
    Department of Medicine, University of Michigan Medical Center, 9220 Medical Sciences Research Building III, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109 0648, USA
    Mol Endocrinol 19:804-11. 2005
    ..In contrast, P44/p42 MAPK (Erk) appeared to provide protection from Fas-mediated apoptosis because an MAPK kinase inhibitor (U0126) ..
  96. doi Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells
    Peggy Kirstetter
    European Molecular Biology Laboratory, Mouse Biology Unit, Monterotondo 00016, Italy
    Cancer Cell 13:299-310. 2008
    ..To mimic the most common mutations affecting CEBPA-that is, those leading to loss of the 42 kDa C/EBPalpha isoform (p42) while retaining the 30kDa isoform (p30)-we modified the mouse Cebpa locus to express only p30...
  97. ncbi Follicle-stimulating hormone-induced aromatase in immature rat Sertoli cells requires an active phosphatidylinositol 3-kinase pathway and is inhibited via the mitogen-activated protein kinase signaling pathway
    Claudia A McDonald
    Olson Center for Women s Health, Department of Obstetrics and Gynecology, 983255 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, Nebraska 68198 3255, USA
    Mol Endocrinol 20:608-18. 2006
    ..analysis was performed to determine the effects of FSH and EGF on levels of activated (phosphorylated) AKT1 and p42 ERK2 and p44 ERK1, also named MAPK1 and MAPK3, respectively...
  98. ncbi A novel chitin-binding protein identified from the peritrophic membrane of the cabbage looper, Trichoplusia ni
    Wei Guo
    Department of Entomology, Cornell University, New York State Agricultural Experiment Station, Geneva, NY 14456, USA
    Insect Biochem Mol Biol 35:1224-34. 2005
    A novel midgut peritrophic membrane (PM) protein, TnPM-P42, was identified from the cabbage looper, Trichoplusia ni...
  99. ncbi Mos mediates the mitotic activation of p42 MAPK in Xenopus egg extracts
    Jianbo Yue
    Department of Molecular Pharmacology, Stanford University, Stanford, CA 94305 5174, USA
    Curr Biol 14:1581-6. 2004
    ..The MAPK activator MEK1 is required for mitotic activation of p42 MAPK in Xenopus egg extracts; however, the identity of the kinase that activates MEK1 is unknown...
  100. doi Role of the CXCR4/CXCL12 axis in lymphangioleiomyomatosis and angiomyolipoma
    Debbie Clements
    Division of Therapeutics and Molecular Medicine and National Institute for Health Research Respiratory Biomedical Research Unit, University of Nottingham, University Hospital, Queens Medical Centre, Nottingham, United Kingdom
    J Immunol 185:1812-21. 2010
    ..In AML cells, their ligands CXCL12 CX3CL1, CCL11, CCL24, and CCL28 caused robust phosphorylation of p42/44 MAPK and Akt...
  101. ncbi Growth and molecular interactions of the anti-EGFR antibody cetuximab and the DNA cross-linking agent cisplatin in gefitinib-resistant MDA-MB-468 cells: new prospects in the treatment of triple-negative/basal-like breast cancer
    Cristina Oliveras-Ferraros
    Catalan Institute of Oncology ICO, Dr Josep Trueta University Hospital of Girona, E 17007 Girona, Catalonia, Spain
    Int J Oncol 33:1165-76. 2008
    ..Cetuximab, as single agent, to paradoxically induce hyper-phosphorylation of EGFR while concomitantly deactivating p42/44 (ERK1/ERK2) MAPK...

Research Grants62

  1. NOVEL KINASE SIGNALING CASCADES IN PANCREATIC ACINI
    John Williams; Fiscal Year: 2002
    ..CCK activates three mitogen activated protein kinase (MAPK) cascades in rat acini leading to activation of ERKs (p42 and p44 MAPK), Jun Kinase and p38/Reactivating Kinase...
  2. TNF-alpha Signaling in Silica-Induced Lung Fibrosis
    Luis A Ortiz; Fiscal Year: 2012
    ..We also showed that silica promotes activation of p42 MAPK/ERK and induces phosphorylation of TNFR1, a process that modulates silica-induced cytotoxicity in macrophages...
  3. TNF-alpha Control of a Surfactant Enzyme in Lung Injury
    Rama K Mallampalli; Fiscal Year: 2010
    ..One effect of TNFa is the activation multiple kinase pathways, including p42/44 MAP kinase. TNFa also activates calpains and the ubiquitin-proteasome system...
  4. MECHANISMS OF CORONARY FLOW REGULATION BY ADENOSINE
    S Jamal Mustafa; Fiscal Year: 2013
    ..A1 AR in CASMC involves activation of PLC-2III->PKC1 ->p42/44 in causing contraction. A2B causes relaxation thorough p-38 MAPK...
  5. Ligand Directed Functional Selectivity of G-Protein Coupled Receptor Signalling
    Gerry S Oxford; Fiscal Year: 2012
    ..0 channels, CaV2.0 channels, p42/44 MAP kinase (Erk1/2), and 2-arrestin translocation...
  6. Control of Conjuctival Goblet Cell Mucin Production
    Darlene Dartt; Fiscal Year: 2009
    ..and human conjunctival goblet cells will be used to determined if EGF stimulates proliferation by activating 1) p44/p42 mitogen-activated protein kinase, (2) phosphatidylinositol-3 kinase, or (3) PKC isoforms, Proliferation will be ..
  7. TRAINING IN ENVIRONMENTAL PATHOLOGY
    Agnes B Kane; Fiscal Year: 2013
    ..well-funded research programs supported by 27 active research grants, 3 training grants, 2 COBRE grants, an NIEHS P42 Superfund Research Grant, a P20 Formative Center Grant, and a pilot project from the National Children's Study...
  8. Alcohol and Sca-1;Impairment of the granulopoietic precursor cell response
    John Nicholas Melvan; Fiscal Year: 2013
    ..This process involves key cell signaling pathways that down-regulate STAT3 signaling and enhance p44/p42-cyclin D signaling...
  9. Health Effects and Geochemistry of Arsenic and Manganese
    Joseph H Graziano; Fiscal Year: 2013
    ..is submitted in response to RFA-ES-10-010, entitled "Superfund Hazardous Substance Research and Training Program (P42)...
  10. Developmental Teratogenesis of Methylmercury in Hippocampal stem cells
    Maryann Obiorah; Fiscal Year: 2013
    ..Next, the effects of a single early exposure (P7) on later adult neurogenesis (P21, P42) will be studied...
  11. Antigenic variation by multiple promoter inversions in Mycoplasma penetrans
    Michael Calcutt; Fiscal Year: 2009
    ..38 of which constitute a large paralogous family (designated mpl) that includes the abundant lipoproteins P35 and P42. Although the precise function of the mpl family is unknown, the individual members are considered to be ..
  12. MT COBRE: CEHS FACULTY DEVELOPMENT, ADMIN CORE
    Andrij Holian; Fiscal Year: 2011
    ..4) position the Center for training grant and program project grants including a Superfund Basic Research Center (P42)...
  13. Role of p38 and p42/44 MAPK in Pulmonary Arterial Hypertension
    James D West; Fiscal Year: 2011
    ..BMPR2 can signal through several different pathways, including SMAD 1/5/8 and both p38 and p42/44 MAPK...
  14. TRANSCRIPTIONAL REGULATION BY FIBROBLAST GROWTH FACTOR
    Dwight Towler; Fiscal Year: 2001
    ..by expression of dominant negative Ras or MAPK ohosphatase -2, yet is unaffected by inhibition of the classic p44/p42 MAPK cacade...
  15. RAGE and a Novel Tumor Axis
    Ann Schmidt; Fiscal Year: 2005
    ..In murine tumor models, blockade of amphoterin/RAGE suppresses activation of members of the kinase family, p44/p42, p38 and SAPKIJNK involved in modulating tumor proliferation, invasion/migration, and activation of matrix ..
  16. RAGE and modulation of tumor properties
    Emina Huang; Fiscal Year: 2006
    ..In murine tumor models, blockade of amphoterin/RAGE suppressed activation of members of the MAP kinase family, p44/p42, p38 and SAPK/JNK, involved in tumor cell proliferation, invasion/migration, and activation of matrix ..
  17. CYTOSOLIC PHOSPHOLIPASE A2 TRANSFORMED CELLS
    Raphael Nemenoff; Fiscal Year: 2002
    ..cPLA2 is phosphorylated and activated in vitro by two growth-factor regulated protein kinases: protein kinase C and p42 MAP kinase...
  18. METABOLIC CONTROL OF INSULIN EXOCYTOSIS
    Christopher Rhodes; Fiscal Year: 2005
    ..there are two other PP-2B phosphoprotein substrates on the beta-granule to be identified and characterized (p42 and p36)...
  19. AIRWAY MYOCYTE PROLIFERATION AND LYSOSOMAL HYDROLASE
    DUKHEE LEW; Fiscal Year: 2001
    ..Specific aims are: 1) To determine the contribution of p42 and p44 mitogen activated protein kinases (p42/44MAPK) and 70-kD ribosomal protein S6 kinase (p70S6k) in mannosyl-..
  20. SIGNALING MECHANISMS IN PHARMACOLOGICAL PRECONDITIONING
    RAKESH KUKREJA; Fiscal Year: 2004
    ..is that pharmacological triggers of PC activate signaling pathway leading to phosphorylation of p38, p44 and p42 MAP kinases and also cause their translocation in the nucleus...
  21. PX REGION OF HTLV I AND II
    William Haseltine; Fiscal Year: 1992
    ..The focus of research over the past two years has been in the p42 transactivator protein encoded by the pX region...
  22. EARLY S PHASE REPLICATION SITES AS ENVIRONMENTAL TARGETS
    David Kaufman; Fiscal Year: 2002
    ..origins (column with higher affinity for ss-DNA, which origins should have), and has mastered a 2D electrophoresis method to detect unusual DNA structures that are formed during DNA replication (conceptually presented in Fig 18, p42).
  23. Role of PARP-1 in Mediating Inflammatory Gene Transcription
    MITCHELL C JUNG; Fiscal Year: 2010
    ..with a sequence-specific transcription factor(s) and increasing its DMA binding activity;(3) investigate whether p42/44MAPK directly or indirectly phosphprylates and induces PARP-1 catalytic activity in response to LPS;(4) determine ..
  24. Regulation of Cell Signaling and Adhesion
    JOE RAMOS; Fiscal Year: 2006
    ..I have used an expression-cloning strategy to isolate a protein that blocks ERK/MAPK (p42/p44) signaling, PEA-15. PEA-15 impairs several ERK functions such as activation of transcription...
  25. Mechanisms of CD40-mediated Expression of MMPs & TIMP-1
    Peter Chen; Fiscal Year: 2005
    ..enhancer A3 promoter activity on the TIMP-1 gene will be determined as well as the relative roles of the JNK, p42/p44 and p38 MAPK signaling pathways in mediating TIMP-1 expression...
  26. Evaluation of Immunogenicity : Malaria Subunit Vaccine
    David Clements; Fiscal Year: 2002
    ..adjuvants will be evaluated for the ability to elicit an appropriate immune response when combined with an MSP-1 p42 subunit...
  27. A P. falciparum MSP1 p42/QS-21 malaria vaccine
    Sandra Chang; Fiscal Year: 2001
    ..These studies will provide cGMP material and preclinical information for a clinical trial of MSP1.42/QS21 during STTR Phase II. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
  28. ERK/MAPK Signaling and Circadian Clock Entrainment
    GREGORY BUTCHER; Fiscal Year: 2005
    ..Recent evidence has indicated the p42/44 mitogen activated protein kinase (MAPK) signaling pathway couples light to clock entrainment...
  29. CYTOKINE GENE EXPRESSION IN ALVEOLAR MACROPHAGES
    A Carter; Fiscal Year: 2002
    ..The focus of this application is to define the role(s) of the p42/44 MAPK pathway and its interaction with the p38 MAPK pathway in regulating cytokine gene expression in human AM in ..
  30. ARTERIAL INJURY AND SMOOTH MUSCLE CELL SIGNALING
    Michael Reidy; Fiscal Year: 2001
    ..The first group of experiments will document the activation of the MAP kinase pathways, namely p42/44erk in the ballooned injured rat carotid arteries...
  31. Regulation of NO Signaling in Pulmonary Vaculature
    Roger Johns; Fiscal Year: 2006
    ..The second aim will investigate the effect of NO and L-arginase I expression on polyamine activation of p42/p44 protein kinases, p21 and resultant changes in cell cycle and proliferative response of pulmonary microvascular ..
  32. G PROTEIN REGULATION IN THE KIDNEY
    LOUIS ERCOLANI; Fiscal Year: 2000
    ..active pre-differentiated LLC-PKI cells, Gi protein function in growth and differentiation cascades link to p42/44 and/or JNK/SAPK mitogen-activated protein kinases...
  33. Development of a MSP1-p42 Subunit Vaccine for Malaria
    David Clements; Fiscal Year: 2003
    ..Phase I research demonstrated that the MSP-1 p42 antigen is expressed at high levels in the Drosophila cell expression system...
  34. Neural Substrates of Anorexia
    Dawna Salter; Fiscal Year: 2004
    ..NPY neurons immediately after anorexia reversal by using imunohistochemical detection of the phosphorylated form of p42/44 mitogen-activated protein/extracellular sinai-regulated kinase (pERK1/2) and in-situ hybridization for NPY mRNA; ..
  35. OSMOTIC REGULATION OF MACROPHAGES IN CYSTIC FIBROSIS
    David Riches; Fiscal Year: 2003
    ..will involve concurrent activation of p38 MAP kinase and inhibition of pro-survival signals conferred by either p42 ERK and/or Akt...
  36. Mechanism of ethanol-clonidine synergistic sedation
    TARA BENDER; Fiscal Year: 2007
    ..acting at the alpha-2A receptor, enhances the effects of ethanol through a phosphorylation cascade involving p42/44 MARK, which activates nNOS...
  37. REGULATION OF CELLULAR DIFFERENTIATION
    Ian Macara; Fiscal Year: 1991
    ..Vanadate is a potent inhibitor of Friend cell differentiation. Total cell and p42 phosphotyrosine levels will be determined along with measurements of DG, myc RNA and S6 kinase activities...
  38. FUNCTIONAL ANALYSIS OF ETS1 PROTEIN ISOTYPES
    TAKIS PAPAS; Fiscal Year: 1999
    ..understand in detail the mechanism by which an isotype of ETS1, generated as a splicing variant and referred to as p42-ETS1, represses tumorigenicity and induces apoptosis in epithelial cells...
  39. APP AND HIPPOCAMPAL MAP KINASE
    JOHN SWEATT; Fiscal Year: 2000
    ..that the chronic exposure of neurons to elevated levels of extracellular Abeta that occurs in Tg2576 mice affects p42 MAPK regulation...
  40. Regulation of LTP by Gi Linked Receptors
    Danny Winder; Fiscal Year: 2004
    ..This regulation occurs in large part through the recruitment of the cAMP and p42-44 MAP kinase (ERK) signaling cascades in hippocampal neurons...
  41. Cancer: MAPK phosphorylation and nuclear translocation
    DANIEL MARENDA; Fiscal Year: 2005
    ..In mammals, MARK proteins p42/p44 (also called ERK 1/2) phosphorylate and activate a number of targets in both the cytoplasm and the nucleus, and ..
  42. P42/MAP KINASE--STRUCTURE, FUNCTION, AND REGULATION
    Michael Weber; Fiscal Year: 2000
    ..This is a first amended renewal of a grant, currently in its fifth year, to study the regulation and function of p42 MAP kinase. The MAP kinases are crucial components of diverse signalling cascades. In general, Dr...
  43. MOLECULAR MECHANISMS OF DELAYED PRECONDITIONING
    RAKESH KUKREJA; Fiscal Year: 2006
    ..Our second hypothesis is that rapid pacing triggers signaling pathway leading to the phosphorylation of p38, p44/p42 (ERK I & 2) and p46/p54 JNK kinases...
  44. Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol Homeostasis
    Kamal D Mehta; Fiscal Year: 2010
    ..The greatest potential for arresting this epidemic is likely to come through a clearer understanding of its molecular pathogenesis to develop rational and mechanism based therapy. ..
  45. Mechanisms of p42/44MAPK-induced LDL receptor expression
    KAMAL MEHTA; Fiscal Year: 2004
    ..Recently, we provided the first evidence that specific activation of the p42/44mitogen-activated protein kinase (MAPK) is not only required but is sufficient to fully induce LDL receptor ..
  46. Adenosine in trauma and sepsis
    Gyorgy Hasko; Fiscal Year: 2007
    ..abstract_text> ..
  47. Intracellular signaling in anesthetic and hypoxic preconditioning of neurons
    Philip E Bickler; Fiscal Year: 2010
    ..The work will also identify why the aging brain may not be able to benefit from the neuroprotective actions of anesthetics or other preconditioning treatments. ..
  48. Role of EGFR in Viral Infected Lung Epithelial Cells
    Martha M Monick; Fiscal Year: 2010
    ..Completion of these studies will add to our understanding of mechanisms of RSV infection of airway epithelium and the role of targeted signaling pathways in the subsequent inflammation and life span of infected cells. ..
  49. The CXCR4-SDF-1 Axis in Metastatic Rhabdomyosarcoma
    Mariusz Ratajczak; Fiscal Year: 2009
    ..This work will be of relevance for designing strategies to block the SDF-1-CXCR4 axis to treat CXCR4-positive cancers. ..
  50. GLU6PASE AND 6P2K/FBASE GENE REGULATION IN SEPSIS
    SUBIR MAITRA; Fiscal Year: 2001
    ..The results of this study are essential to understand the molecular basis of deranged metabolism in sepsis. Understanding the mechanism might be useful for developing appropriate therapeutic intervention during sepsis. ..
  51. Hypertension and Collagen: Effect of Ac-SDKP
    Nour Eddine Rhaleb; Fiscal Year: 2010
    ..ET-1-stimulated transactivation of the EGFR;2) whether Ac-SDKP inhibits the effects of calcium ionophores or EGF on p42/44 MAPK and collagen synthesis;3) whether PLC, EGFR, cSrc, calmodulin kinase or IP3 inhibitors attenuate MAPK ..
  52. SIGNALING OF MECHANICAL STRAIN IN LUNG EPITHELIAL CELLS
    Patricia Chess; Fiscal Year: 2003
    ..The project is designed to optimize the principle investigator's research development, while yielding information regarding pulmonary epithelial responses to mechanical strain. ..
  53. CELLULAR AND MOLECULAR BASIS OF HIV BASED THROMBOCYTOPEN
    Mariusz Ratajczak; Fiscal Year: 2002
    ..In toto, the studies proposed in this grant will increase the knowledge about pathogenesis of AIDS associated thrombocytopenia and may lead to development of new strategies for its treatment of prevention. (End of Abstract) ..
  54. SATELLITE STEM CELL BIOLOGY
    Frank Booth; Fiscal Year: 2008
    ..The outcomes of the research will provide a more scientific basis to devise therapies to prevent and treat sarcopenia and physical frailty. ..
  55. CHRONIC HYPOXIA AND RESISTANCE TO MYOCARDIAL ISCHEMIA
    John E Baker; Fiscal Year: 2010
    ..kinase signaling cascade: JAK/STAT, Ras, Raf, phosphatidylinositol-3-OH kinase (PI3K)/Akt, PKC, JNK, p38 MARK and p42/44 MARK...
  56. CREB and Synaptic Reorganization
    Karl Obrietan; Fiscal Year: 2007
    ..An understanding of the intracellular signaling events that couple seizures to synaptic remodeling should allow for the development of therapeutic approaches designed to block the development of some forms of epilepsy. ..
  57. Developmental Interactions of methamphetamine and stress
    Michael Williams; Fiscal Year: 2006
    ..The use of different strains of rats prone to hyper- or hyposecretion of HPA axis hormones will be used, as will animals that are exposed to MA without the concurrent increase in CORT. ..
  58. Protein ubiquitination based neuroprotection for stroke
    Robert Meller; Fiscal Year: 2006
    ....
  59. MCP-1, TISSUE FACTOR, AND VASCULAR SMOOTH MUSCLE
    ALISON SCHECTER; Fiscal Year: 2002
    ..The receptor will be expressed in COS cells to study the properties of the new receptor in mammalian cells and, in particular, to examine its coupling to TF induction. ..