Gene Symbol: NUP214
Description: nucleoporin 214
Alias: CAIN, CAN, nuclear pore complex protein Nup214, CAN protein, putative oncogene, nucleoporin 214kDa
Species: human
Products:     NUP214

Top Publications

  1. Stoffler D, Fahrenkrog B, Aebi U. The nuclear pore complex: from molecular architecture to functional dynamics. Curr Opin Cell Biol. 1999;11:391-401 pubmed
    ..Structural changes of native NPCs mediated by physiological effectors such as calcium or ATP were monitored by time-lapse atomic force microscopy, thus revealing a first glimpse of the NPC's functional dynamics. ..
  2. Saito S, Nouno K, Shimizu R, Yamamoto M, Nagata K. Impairment of erythroid and megakaryocytic differentiation by a leukemia-associated and t(9;9)-derived fusion gene product, SET/TAF-Ibeta-CAN/Nup214. J Cell Physiol. 2008;214:322-33 pubmed
    SET-CAN associated with the t(9;9) in acute undifferentiated leukemia encodes almost the entire sequence of SET and the C-terminal two-third portion of CAN, including the FG repeat region...
  3. Kraemer D, Wozniak R, Blobel G, Radu A. The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm. Proc Natl Acad Sci U S A. 1994;91:1519-23 pubmed
    ..In agreement with previously proposed nomenclature for nucleoporins, we propose the alternative term nup214 (nucleoporin of 214 kDa) for the CAN protein.
  4. Stutz F, Izaurralde E, Mattaj I, Rosbash M. A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus. Mol Cell Biol. 1996;16:7144-50 pubmed
    ..The results suggest that Rev and cellular mediators of RNA export can interact with multiple components of the nuclear pore complex during transport, analogous to the proposed mode of ..
  5. Fornerod M, van Deursen J, van Baal S, Reynolds A, Davis D, Murti K, et al. The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88. EMBO J. 1997;16:807-16 pubmed
    The oncogenic nucleoporin CAN/Nup214 is essential in vertebrate cells. Its depletion results in defective nuclear protein import, inhibition of messenger RNA export and cell cycle arrest...
  6. Bachi A, Braun I, Rodrigues J, Pante N, Ribbeck K, von Kobbe C, et al. The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates. RNA. 2000;6:136-58 pubmed
    ..TAP interacts with multiple components of the NPC including the nucleoporins CAN, Nup98, Nup153, p62, and with three major NPC subcomplexes...
  7. Hofmann W, Reichart B, Ewald A, Muller E, Schmitt I, Stauber R, et al. Cofactor requirements for nuclear export of Rev response element (RRE)- and constitutive transport element (CTE)-containing retroviral RNAs. An unexpected role for actin. J Cell Biol. 2001;152:895-910 pubmed
    ..for efficient interaction of Rev-NES with CRM1/exportin1 and that eIF-5A interacts with the nucleoporins CAN/nup214, nup153, nup98, and nup62. Quite unexpectedly, nuclear actin was also identified as an eIF-5A binding protein...
  8. Stochaj U, Bański P, Kodiha M, Matusiewicz N. The N-terminal domain of the mammalian nucleoporin p62 interacts with other nucleoporins of the FXFG family during interphase. Exp Cell Res. 2006;312:2490-9 pubmed
    ..Using the p62 N-terminal segment as bait, we affinity-purified nucleoporins Nup358, Nup214 and Nup153 from crude cell extracts...
  9. Rosati R, La Starza R, Barba G, Gorello P, Pierini V, Matteucci C, et al. Cryptic chromosome 9q34 deletion generates TAF-Ialpha/CAN and TAF-Ibeta/CAN fusion transcripts in acute myeloid leukemia. Haematologica. 2007;92:232-5 pubmed
    ..The 9q34 deletion extends 2.5 megabases and juxtaposes the 5' TAF-I to the 3' CAN producing a TAF-I/CAN fusion gene...

More Information

Publications132 found, 100 shown here

  1. Van Vlierberghe P, van Grotel M, Tchinda J, Lee C, Beverloo H, van der Spek P, et al. The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia. Blood. 2008;111:4668-80 pubmed publisher
    ..11q34.13), was exclusively identified in 3 of these 5 patients. This deletion results in a conserved SET-NUP214 fusion product, which was also identified in the T-ALL cell line LOUCY...
  2. von Lindern M, Fornerod M, van Baal S, Jaegle M, de Wit T, Buijs A, et al. The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA. Mol Cell Biol. 1992;12:1687-97 pubmed
    ..Previously, it was found that breakpoints on chromosome 9 are clustered in one of the introns of a large gene named Cain (can). cDNA probes derived from the 3' part of can detect an aberrant, leukemia-specific 5...
  3. Zolotukhin A, Felber B. Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev. J Virol. 1999;73:120-7 pubmed
    ..First, we found that upon actinomycin D treatment, Nup98, but not Nup214 or Nup153, is able to translocate to the cytoplasm of HeLa cells, demonstrating that Nup98 may act as a soluble ..
  4. Paulillo S, Phillips E, Köser J, Sauder U, Ullman K, Powers M, et al. Nucleoporin domain topology is linked to the transport status of the nuclear pore complex. J Mol Biol. 2005;351:784-98 pubmed
    ..By using domain-specific antibodies, we have now mapped the domain topology of Nup214 in Xenopus oocytes and in human somatic cells by immuno-EM...
  5. Bernad R, Engelsma D, Sanderson H, Pickersgill H, Fornerod M. Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear export. J Biol Chem. 2006;281:19378-86 pubmed
    ..Using RNA interference, we depleted two FG-containing cytoplasmically oriented NPC complexes, Nup214-Nup88 and Nup358, and investigated CRM1-mediated export...
  6. Boer J, Bonten Surtel J, Grosveld G. Overexpression of the nucleoporin CAN/NUP214 induces growth arrest, nucleocytoplasmic transport defects, and apoptosis. Mol Cell Biol. 1998;18:1236-47 pubmed
    ..CAN, also called NUP214, is a nuclear pore complex (NPC) protein that contains multiple FG-peptide sequence motifs...
  7. Bogerd H, Echarri A, Ross T, Cullen B. Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1. J Virol. 1998;72:8627-35 pubmed
    ..GTP. Overexpression of a truncated, defective form of the nucleoporin Nup214/CAN, termed DeltaCAN, that retains Crm1 binding ability resulted in the effective inhibition of HIV-1 Rev or human ..
  8. Katahira J, Strasser K, Podtelejnikov A, Mann M, Jung J, Hurt E. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. EMBO J. 1999;18:2593-609 pubmed
    ..Both the FG-repeat domain of nucleoporin CAN/Nup214 and a novel human 15 kDa protein (p15) with homology to NTF2 (a nuclear transport factor which associates with ..
  9. Griffis E, Xu S, Powers M. Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes. Mol Biol Cell. 2003;14:600-10 pubmed
    ..the pore-targeting domain of Nup98 interacts directly with the cytoplasmic nucleoporin Nup88, a component of the Nup214, Nup88, Nup62 subcomplex...
  10. Gurda G, Guo L, Lee S, Molkentin J, Williams J. Cholecystokinin activates pancreatic calcineurin-NFAT signaling in vitro and in vivo. Mol Biol Cell. 2008;19:198-206 pubmed
    ..changes were blocked by immunosuppressants FK506 and CsA and by overexpression of the endogenous protein inhibitor CAIN. Parallel NFAT activation took place in vivo...
  11. Cassany A, Ragues J, Guan T, Bégu D, Wodrich H, Kann M, et al. Nuclear import of adenovirus DNA involves direct interaction of hexon with an N-terminal domain of the nucleoporin Nup214. J Virol. 2015;89:1719-30 pubmed publisher
    ..We used RNA interference (RNAi) to deplete cells of either Nup214 or Nup358, the two major Phe-Gly (FG) repeat nucleoporins localized on the cytoplasmic side of the NPC, and ..
  12. Kane M, Rebensburg S, Takata M, Zang T, Yamashita M, Kvaratskhelia M, et al. Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2. elife. 2018;7: pubmed publisher
    ..mutants could be induced or abolished by manipulating levels of the Nup93 subcomplex, the Nup62 subcomplex, NUP88, NUP214, RANBP2, or NUP153...
  13. Tan W, Zolotukhin A, Bear J, Patenaude D, Felber B. The mRNA export in Caenorhabditis elegans is mediated by Ce-NXF-1, an ortholog of human TAP/NXF and Saccharomyces cerevisiae Mex67p. RNA. 2000;6:1762-72 pubmed
    ..This region was shown to interact with the FG-repeat domains of nucleoporins Nup98, Nup153, and Nup214, indicating that the rim association occurs through components of the nuclear pore complex...
  14. Lee K, Hsu I, Tarn W. TRAP150 activates pre-mRNA splicing and promotes nuclear mRNA degradation. Nucleic Acids Res. 2010;38:3340-50 pubmed publisher
    ..Unexpectedly, when tethered to a precursor mRNA, TRAP150 can trigger mRNA degradation in the nucleus...
  15. Jühlen R, Fahrenkrog B. Moonlighting nuclear pore proteins: tissue-specific nucleoporin function in health and disease. Histochem Cell Biol. 2018;150:593-605 pubmed publisher
    ..Malfunctioning of nucleoporins is well known in human malignancies, such as gene fusions of NUP214 and NUP98 in hematological neoplasms and overexpression of NUP88 in a variety of human cancers...
  16. Schilthuizen M. Rapid, habitat-related evolution of land snail colour morphs on reclaimed land. Heredity (Edinb). 2013;110:247-52 pubmed publisher
    ..populations in shaded habitats had evolved towards darker shells than those in adjacent open habitats, whereas a 'Cain & Sheppard' diagram (proportion yellow shells plotted against 'effectively unbanded' shells) failed to reveal a ..
  17. Platzbecker U, Middeke J, Sockel K, Herbst R, Wolf D, Baldus C, et al. Measurable residual disease-guided treatment with azacitidine to prevent haematological relapse in patients with myelodysplastic syndrome and acute myeloid leukaemia (RELAZA2): an open-label, multicentre, phase 2 trial. Lancet Oncol. 2018;19:1668-1679 pubmed publisher
    ..during 24 months from baseline by either quantitative PCR for mutant NPM1, leukaemia-specific fusion genes (DEK-NUP214, RUNX1-RUNX1T1, CBFb-MYH11), or analysis of donor-chimaerism in flow cytometry-sorted CD34-positive cells in ..
  18. Cocker M, Spence J, Hammond R, dekemp R, Lum C, Wells G, et al. [18F]-Fluorodeoxyglucose PET/CT imaging as a marker of carotid plaque inflammation: Comparison to immunohistology and relationship to acuity of events. Int J Cardiol. 2018;271:378-386 pubmed publisher
    ..15 ± 0.87 vs. 2.52 ± 0.45, p = 0.015). In this CAIN cohort, 18FDG uptake imaged with PET/CT serves a surrogate marker of intraplaque inflammatory macrophage,..
  19. Mendes A, Fahrenkrog B. NUP214 in Leukemia: It's More than Transport. Cells. 2019;8: pubmed publisher
    b>NUP214 is a component of the nuclear pore complex (NPC) with a key role in protein and mRNA nuclear export...
  20. De Keersmaecker K, Rocnik J, Bernad R, Lee B, Leeman D, Gielen O, et al. Kinase activation and transformation by NUP214-ABL1 is dependent on the context of the nuclear pore. Mol Cell. 2008;31:134-42 pubmed publisher
    ..We report that the NUP214-ABL1 fusion is unique among these because of its requisite localization to the nuclear pore complex for its ..
  21. Shamseldin H, Makhseed N, Ibrahim N, Al Sheddi T, Alobeid E, Abdulwahab F, et al. NUP214 deficiency causes severe encephalopathy and microcephaly in humans. Hum Genet. 2019;138:221-229 pubmed publisher which whole exome sequencing revealed the presence of a novel homozygous missense variant in NUP214. Functional analysis of patient-derived fibroblasts recapitulated the dysmorphic phenotype of nuclei that was ..
  22. Miyauchi Y, Sakaguchi N, Okada T, Makishima M, Ozono K, Michigami T. Oncogenic nucleoporin CAN/Nup214 interacts with vitamin D receptor and modulates its function. J Cell Biochem. 2009;106:1090-101 pubmed publisher
    ..two-hybrid approach, and found that VDR binds to the carboxy-terminal region of an oncogenic nucleoporin, CAN/Nup214. CAN/Nup214 was originally identified through its involvement in a certain type of acute myeloid leukemia, and is ..
  23. Klener P, Fronkova E, Berkova A, Jaksa R, Lhotska H, Forsterova K, et al. Mantle cell lymphoma-variant Richter syndrome: Detailed molecular-cytogenetic and backtracking analysis reveals slow evolution of a pre-MCL clone in parallel with CLL over several years. Int J Cancer. 2016;139:2252-60 pubmed publisher
    ..canonical t(11;14)(q13;q32) translocation) including gain of one copy of ATM gene or emergence of TP53, CREBBP, NUP214, FUBP1 and SF3B1 gene mutations...
  24. Li H, Spagnol G, Pontifex T, Burt J, Sorgen P. Chemical shift assignments of the connexin37 carboxyl terminal domain. Biomol NMR Assign. 2017;11:137-141 pubmed publisher
    ..Overall, these assignments will be useful for identifying the binding sites for intra- and inter-molecular interactions that affect Cx37 channel activity. ..
  25. Liu F, Gao L, Jing Y, Xu Y, Ding Y, Zhou M, et al. Detection and clinical significance of gene rearrangements in Chinese patients with adult acute lymphoblastic leukemia. Leuk Lymphoma. 2013;54:1521-6 pubmed publisher
    ..BCR-ABL1, FUS-ERG, MLL-AF4, ETV6-RUNX1, E2A-PBX1, dupMLL, MLL-AF10, MLL-ENL, SET-NUP214 and SIL-TAL1 were detected in 36 (14.06%), 14 (5.47%), 14 (5.47%), four (1.56%), four (1.56%), five (1...
  26. Quentmeier H, Schneider B, Röhrs S, Romani J, Zaborski M, MacLeod R, et al. SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines. J Hematol Oncol. 2009;2:3 pubmed publisher
    SET-NUP214 fusion resulting from a recurrent cryptic deletion, del(9)(q34.11q34.13) has recently been described in T-cell acute lymphoblastic leukemia (T-ALL) and in one case of acute myeloid leukemia (AML)...
  27. Kapinos L, Schoch R, Wagner R, Schleicher K, Lim R. Karyopherin-centric control of nuclear pores based on molecular occupancy and kinetic analysis of multivalent binding with FG nucleoporins. Biophys J. 2014;106:1751-62 pubmed publisher
    ..A general feature of the FxFG domains of Nup214, Nup62, and Nup153 is their capacity to extend and accommodate large numbers of Kapβ1 molecules at physiological ..
  28. Sandén C, Ageberg M, Petersson J, Lennartsson A, Gullberg U. Forced expression of the DEK-NUP214 fusion protein promotes proliferation dependent on upregulation of mTOR. BMC Cancer. 2013;13:440 pubmed publisher
    ..chromosomal translocation is found in 1% of acute myeloid leukemia and encodes the fusion protein DEK-NUP214 (formerly DEK-CAN) with largely uncharacterized functions...
  29. Zhou M, Yang Q. NUP214 fusion genes in acute leukemia (Review). Oncol Lett. 2014;8:959-962 pubmed
    Nucleoporin 214 (NUP214), previously termed CAN, is required for cell cycle and nucleocytoplasmic transport...
  30. Port S, Monecke T, Dickmanns A, Spillner C, Hofele R, Urlaub H, et al. Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export. Cell Rep. 2015;13:690-702 pubmed publisher
    ..On the cytoplasmic side of the nuclear pore, CRM1 tightly interacts with the nucleoporin Nup214. Here, we present the crystal structure of a 117-amino-acid FG-repeat-containing fragment of Nup214, in complex ..
  31. Lin D, Correia A, Cai S, Huber F, Jette C, Hoelz A. Structural and functional analysis of mRNA export regulation by the nuclear pore complex. Nat Commun. 2018;9:2319 pubmed publisher
    ..In the final step of mRNA export, the DEAD-box helicase DDX19 is activated by the nucleoporins Gle1, Nup214, and Nup42 to remove Nxf1•Nxt1 from mRNAs...
  32. Chen X, Wang F, Zhang Y, Wang M, Tian W, Teng W, et al. Retrospective analysis of 36 fusion genes in 2479 Chinese patients of de novo acute lymphoblastic leukemia. Leuk Res. 2018;72:99-104 pubmed publisher
    ..001). Pediatric ALL had higher prevalence of ETV6-RUNX1, TCF3-PBX1, and STIL-TAL1, while BCR-ABL1 and SET-NUP214 were more common in adult ALL. BCR-ABL1, TCF3-PBX1, KMT2A-AFF1 and ETV6-RUNX1 were more frequent in B-ALL...
  33. Chen B, Jiang L, Zhong M, Li J, Li B, Peng L, et al. Identification of fusion genes and characterization of transcriptome features in T-cell acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2018;115:373-378 pubmed publisher
    ..Thirty-six distinct gene fusion transcripts were identified, with SET-NUP214 being highly related to adult cases...
  34. Hansel W. After 65 years, research is still fun. Annu Rev Anim Biosci. 2013;1:1-20 pubmed publisher
    ..At age seventy, I retired from Cornell and accepted the Gordon Cain Endowed Professorship at Louisiana State University, where I continued my work on the bovine corpus luteum and ..
  35. Graux C, Cools J, Melotte C, Quentmeier H, Ferrando A, Levine R, et al. Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia. Nat Genet. 2004;36:1084-9 pubmed
    ..analyses delineated the amplicon as a 500-kb region from chromosome band 9q34, containing the oncogenes ABL1 and NUP214 (refs. 5,6)...
  36. Herzlinger D. Upper urinary tract pacemaker cells join the GLI club. J Clin Invest. 2011;121:836-8 pubmed publisher
    ..In this issue of the JCI, Cain and colleagues show that tightly regulated GLI3 repressor activity is essential for Shh-dependent differentiation ..
  37. Xu S, Dai J, Yang J, You J, Hao J. Facile Synthesis of Novel CaIn?S?/ZnIn?S? Composites with Efficient Performance for Photocatalytic Reduction of Cr(VI) under Simulated Sunlight Irradiation. Nanomaterials (Basel). 2018;8: pubmed publisher
    A series of novel and efficient heterostructured composites CaIn?S?/ZnIn?S? have been synthesized using a facile hydrothermal method...
  38. Egloff M, Nguyen L, Siquier Pernet K, Cormier Daire V, Baujat G, Attie Bitach T, et al. Whole-exome sequence analysis highlights the role of unmasked recessive mutations in copy number variants with incomplete penetrance. Eur J Hum Genet. 2018;26:912-918 pubmed publisher
    ..This strategy allowed us to identify a candidate variant in two patients in the NUP214 and NCOR1 genes...
  39. Ceroni J, Dutra R, Honjo R, Llerena J, Acosta A, Medeiros P, et al. A Multicentric Brazilian Investigative Study of Copy Number Variations in Patients with Congenital Anomalies and Intellectual Disability. Sci Rep. 2018;8:13382 pubmed publisher
    ..In these cases, clinical evaluation followed by karyotyping and MLPA analysis is a helpful and affordable solution for diagnostic purposes. ..
  40. Anders K, Barekzi N, Best A, Frederick G, Mavrodi D, Vazquez E, et al. Genome Sequences of Mycobacteriophages Amgine, Amohnition, Bella96, Cain, DarthP, Hammy, Krueger, LastHope, Peanam, PhelpsODU, Phrank, SirPhilip, Slimphazie, and Unicorn. Genome Announc. 2017;5: pubmed publisher
    ..Four are closely related to subcluster K1 phages, and 10 are members of subcluster K6. The phage genomes span considerable sequence diversity, including multiple types of integrases and integration sites. ..
  41. Makise M, Nakamura H, Kuniyasu A. The role of vimentin in the tumor marker Nup88-dependent multinucleated phenotype. BMC Cancer. 2018;18:519 pubmed publisher
    ..was identified as a Nup88 interacting partner, although it did not bind to other nucleoporins, such as Nup50, Nup214, and Nup358, in HeLa cell lysates...
  42. daSilva E, Crager K, Geisler D, Newbern P, Orem B, Puce A. Something to sink your teeth into: The presence of teeth augments ERPs to mouth expressions. Neuroimage. 2016;127:227-241 pubmed publisher
    If the whites of the sclera can impact neural processing of eye expressions (Hardee, Thompson, & Puce, 2008; Whalen et al...
  43. Farjot G, Sergeant A, Mikaelian I. A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1. J Biol Chem. 1999;274:17309-17 pubmed
    ..We show here that NLP-1, like the previously described Rev-interacting protein hRIP/Rab and several nucleoporins, also interacts with CRM-1 both in yeast and mammalian cells. ..
  44. Montpetit B, Thomsen N, Helmke K, Seeliger M, Berger J, Weis K. A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export. Nature. 2011;472:238-42 pubmed publisher
    ..Dbp5 is localized to the NPC via an interaction with Nup159 (NUP214 in vertebrates) and is locally activated there by Gle1 together with the small-molecule inositol hexakisphosphate (..
  45. Vanden Bempt M, Demeyer S, Broux M, De Bie J, Bornschein S, Mentens N, et al. Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia. Cancer Cell. 2018;34:271-285.e7 pubmed publisher
    The NUP214-ABL1 fusion is a constitutively activated tyrosine kinase that is significantly associated with overexpression of the TLX1 and TLX3 transcription factors in T cell acute lymphoblastic leukemia (T-ALL)...
  46. Lai M, Lee Y, Tarn W. The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control. Mol Biol Cell. 2008;19:3847-58 pubmed publisher
    ..Given that the DDX3 RNA helicase activity is essential for its involvement in translation, we suggest that DDX3 facilitates translation by resolving secondary structures of the 5'-untranslated region in mRNAs during ribosome scanning. ..
  47. Siriangkanakun S, Li Chan E, Yongsawadigul J. Identification and characterization of alpha-I-proteinase inhibitor from common carp sarcoplasmic proteins. Food Chem. 2016;192:1090-7 pubmed publisher
    ..High stability toward NaCl was also evident up to 3M. The common carp α1-PI effectively reduced autolytic degradation of bigeye snapper surimi at the concentration as low as 0.025%. ..
  48. Tan P, Aramburu I, Mercadante D, Tyagi S, Chowdhury A, Spitz D, et al. Two Differential Binding Mechanisms of FG-Nucleoporins and Nuclear Transport Receptors. Cell Rep. 2018;22:3660-3671 pubmed publisher
    ..Here, we use single-molecule studies combined with atomistic simulations to show that, in sharp contrast, FG-Nup214 undergoes a coupled reconfiguration-binding mechanism when interacting with the export receptor CRM1...
  49. Woodward C, Chow S. The nuclear pore complex: a new dynamic in HIV-1 replication. Nucleus. 2010;1:18-22 pubmed publisher
    ..This article discusses how NPC conformation and constitution might influence nuclear import of the PIC, and the subsequent integration of the viral cDNA into actively transcribed genes. ..
  50. Wilkes M, Repellin C, Kang J, Andrianifahanana M, Yin X, Leof E. Sorting nexin 9 differentiates ligand-activated Smad3 from Smad2 for nuclear import and transforming growth factor β signaling. Mol Biol Cell. 2015;26:3879-91 pubmed publisher
    ..Although SNX9 does not bind nucleoporins Nup153 or Nup214 or some β importins (Imp7 or Impβ), it mediates the association of pSmad3 with Imp8 and the nuclear membrane...
  51. Schenk S, Minda J, Lech R, Suchan B. Out of sight, out of mind: Categorization learning and normal aging. Neuropsychologia. 2016;91:222-233 pubmed publisher
    ..In addition, the present study suggests that categorization learning is affected by normal aging and modulated by perceptual processing and visual attention. ..
  52. Okubo Y, Kitamura T, Anzai M, Endo W, Inui T, Takezawa Y, et al. A patient with Muenke syndrome manifesting migrating neonatal seizures. Brain Dev. 2017;39:873-876 pubmed publisher
    ..However, the long-term seizure prognosis was favorable. Results from this and previous studies failed to support the notion that FGFR3 (P250) mutation results in epileptic encephalopathy. ..
  53. Tobe M, Saito S. History of T-cain: a local anesthetic developed and manufactured in Japan. J Anesth. 2015;29:763-8 pubmed publisher
    ..In contrast, T-cain is not included in these lists, even though it has been reported to be suitable for spinal anesthesia in Japan...
  54. daSilva E, Crager K, Puce A. On dissociating the neural time course of the processing of positive emotions. Neuropsychologia. 2016;83:123-137 pubmed publisher
    ..Additionally, some ERP differences may also reflect variations in categorization difficulty. ..
  55. Yuan S, Luo T, Liu Z, Lin Y. Efficacy of different fluids preload on propofol injection pain: A randomized, controlled, double-blinded study. J Huazhong Univ Sci Technolog Med Sci. 2016;36:249-253 pubmed publisher
    ..05). There was no significant difference between P500 and G500 groups. It is suggested that Plasma-Lyte A or Gelofusine preload with 500 mL before propofol injection is effective in alleviating propofol-induced pain. ..
  56. Wang Y, Miller S, Roulston D, Bixby D, Shao L. Genome-Wide Single-Nucleotide Polymorphism Array Analysis Improves Prognostication of Acute Lymphoblastic Leukemia/Lymphoma. J Mol Diagn. 2016;18:595-603 pubmed publisher
    ..low hypodiploidy (two cases with a normal karyotype), and one case each with fusion genes ETV6-NTRK3, CRLF2-P2RY8, NUP214-ABL1, and SET-NUP214...
  57. Chi F, Wei X, Qin Y, Li F, Chen Y, Duan C, et al. Investigation on the site occupation of rare-earth ions in CaIn2O4 with the fluorescence probe of Eu3. Phys Chem Chem Phys. 2017;19:12473-12479 pubmed publisher
    Rare-earth doped CaIn2O4 phosphors have been widely investigated due to their excellent luminescent property, but the site occupation of rare-earth ions in CaIn2O4 is not very clear and needs to ..
  58. Chang Y, Lin S, Meng L, Fan Y. Atypical temporal activation pattern and central-right brain compensation during semantic judgment task in children with early left brain damage. Brain Lang. 2018;177-178:37-43 pubmed publisher
    ..During semantic processing, the orthography has a greater effect on the children with ELBD, and a later semantic reanalysis (P600) is required due to the less efficient N400 at the former stage for semantic integration. ..
  59. De Keersmaecker K, Porcu M, Cox L, Girardi T, Vandepoel R, de Beeck J, et al. NUP214-ABL1-mediated cell proliferation in T-cell acute lymphoblastic leukemia is dependent on the LCK kinase and various interacting proteins. Haematologica. 2014;99:85-93 pubmed publisher
    The NUP214-ABL1 fusion protein is a constitutively active protein tyrosine kinase that is found in 6% of patients with T-cell acute lymphoblastic leukemia and that promotes proliferation and survival of T-lymphoblasts...
  60. Dasgupta Y, Koptyra M, Hoser G, Kantekure K, Roy D, Gornicka B, et al. Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases. Blood. 2016;127:2131-43 pubmed publisher
    Leukemias expressing constitutively activated mutants of ABL1 tyrosine kinase (BCR-ABL1, TEL-ABL1, NUP214-ABL1) usually contain at least 1 normal ABL1 allele...
  61. Scott L, Thoma C, Puglia L, Temple P, D Aguilar A. Implementing a UDL Framework: A Study of Current Personnel Preparation Practices. Intellect Dev Disabil. 2017;55:25-36 pubmed publisher
    ..educational researchers to set an agenda to guide the field in terms of research, practice, and policy ( Thoma, Cain, & Walther-Thomas, 2015 )...
  62. Yaseen N, Blobel G. Cloning and characterization of human karyopherin beta3. Proc Natl Acad Sci U S A. 1997;94:4451-6 pubmed
    ..It bound to several of the repeat-containing nucleoporins (Nup358, Nup214, Nup153, Nup98, and p62) in overlay and solution-binding assays and was competed away by karyopherin beta1...
  63. Copeland A, Newcomb W, Brown J. Herpes simplex virus replication: roles of viral proteins and nucleoporins in capsid-nucleus attachment. J Virol. 2009;83:1660-8 pubmed publisher
    ..with antibodies specific for nucleoporins demonstrated attenuation by antibodies specific for Nup358 but not Nup214. The role of nucleoporins was further investigated with the use of small interfering RNA (siRNA)...
  64. Pasdeloup D, Blondel D, Isidro A, Rixon F. Herpesvirus capsid association with the nuclear pore complex and viral DNA release involve the nucleoporin CAN/Nup214 and the capsid protein pUL25. J Virol. 2009;83:6610-23 pubmed publisher
    ..Here we show that herpes simplex virus type 1 (HSV-1) capsids interact with the nucleoporin CAN/Nup214 in infected cells and that RNA silencing of CAN/Nup214 delays the onset of viral DNA replication in the nucleus...
  65. Hodroj D, Recolin B, Serhal K, Martinez S, Tsanov N, Abou Merhi R, et al. An ATR-dependent function for the Ddx19 RNA helicase in nuclear R-loop metabolism. EMBO J. 2017;36:1182-1198 pubmed publisher
    ..Furthermore, mutation of a residue phosphorylated by Chk1 in Ddx19 disrupts its interaction with Nup214 and allows its nuclear relocalization...
  66. Bogerd H, Wiegand H, Yang J, Cullen B. Mutational definition of functional domains within the Rev homolog encoded by human endogenous retrovirus K. J Virol. 2000;74:9353-61 pubmed
  67. Xu L, Kang Y, Cöl S, Massague J. Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus. Mol Cell. 2002;10:271-82 pubmed
    ..We uncovered direct interactions of Smad2 with the nucleoporins CAN/Nup214 and Nup153. These interactions mediate constitutive nucleocytoplasmic shuttling of Smad2...
  68. Sandahl J, Coenen E, Forestier E, Harbott J, Johansson B, Kerndrup G, et al. t(6;9)(p22;q34)/DEK-NUP214-rearranged pediatric myeloid leukemia: an international study of 62 patients. Haematologica. 2014;99:865-72 pubmed publisher
    ..multicenter study presents the clinical and genetic characteristics of 62 pediatric patients with t(6;9)/DEK-NUP214-rearranged myeloid leukemia; 54 diagnosed as having acute myeloid leukemia, representing <1% of all childhood ..
  69. Iwamoto M, Osakada H, Mori C, Fukuda Y, Nagao K, Obuse C, et al. Compositionally distinct nuclear pore complexes of functionally distinct dimorphic nuclei in the ciliate Tetrahymena. J Cell Sci. 2017;130:1822-1834 pubmed publisher
    ..Core members of the Nup107-Nup160 scaffold complex were enriched in MIC NPCs. Strikingly, two paralogs of Nup214 and of Nup153 localized exclusively to either the MAC or MIC NPCs...
  70. Kuersten S, Arts G, Walther T, Englmeier L, Mattaj I. Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains. Mol Cell Biol. 2002;22:5708-20 pubmed
    ..N terminus binds to both Nup153 and RanBP2/Nup358 in a RanGTP-dependent manner, while the C terminus binds to CAN/Nup214 independently of Ran...
  71. Hutten S, Kehlenbach R. Nup214 is required for CRM1-dependent nuclear protein export in vivo. Mol Cell Biol. 2006;26:6772-85 pubmed
    ..To address this question, we depleted cells of the cytoplasmic nucleoporins Nup214/CAN and Nup358/RanBP2 by RNA interference...
  72. Saito S, Çiğdem S, Okuwaki M, Nagata K. Leukemia-Associated Nup214 Fusion Proteins Disturb the XPO1-Mediated Nuclear-Cytoplasmic Transport Pathway and Thereby the NF-?B Signaling Pathway. Mol Cell Biol. 2016;36:1820-35 pubmed publisher
    ..b>Nup214, a component of nuclear pore complexes, has been found as chimeric fusion proteins in leukemia...
  73. Wang I, Burckhardt C, Yakimovich A, Morf M, Greber U. The nuclear export factor CRM1 controls juxta-nuclear microtubule-dependent virus transport. J Cell Sci. 2017;130:2185-2195 pubmed publisher
    ..LMB-inhibited CRM1 did not compete with adenovirus for binding to the nucleoporin Nup214 at the NPC...
  74. Alanee S, Delfino K, Wilber A, Robinson K, Brard L, Semaan A. Single nucleotide variant in Nucleoporin 107 may be predictive of sensitivity to chemotherapy in patients with ovarian cancer. Pharmacogenet Genomics. 2017;27:264-269 pubmed publisher
    ..whereas rs2302811 (3662-4A>G) in Nucleoporin 188 (Nup188) and rs77246077 (3420-67T>A) in Nucleoporin 214 (Nup214) were associated with platinum sensitivity (P=0.0483 and 0.0091, respectively)...
  75. von Moeller H, Basquin C, Conti E. The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner. Nat Struct Mol Biol. 2009;16:247-54 pubmed publisher
    ..determined the crystal structures of human DBP5 bound to RNA and AMPPNP, and bound to the cytoplasmic nucleoporin NUP214. The structures reveal that binding of DBP5 to nucleic acid and to NUP214 is mutually exclusive...
  76. Aguayo Gómez A, Arteaga Vázquez J, Svyryd Y, Calderón Colmenero J, Zamora González C, Vargas Alarcón G, et al. Identification of Copy Number Variations in Isolated Tetralogy of Fallot. Pediatr Cardiol. 2015;36:1642-6 pubmed publisher
    ..This deletion was not present in the patient's parents and 104 chromosomes from healthy control subjects. Our results clearly suggest a possible etiologic association between the TBX1 deletion and the ToF in our patient. ..
  77. Chen Y, Zhang L, Huang J, Hong X, Zhao J, Wang Z, et al. Dasatinib and chemotherapy in a patient with early T-cell precursor acute lymphoblastic leukemia and NUP214-ABL1 fusion: A case report. Exp Ther Med. 2017;14:3979-3984 pubmed publisher
    ..efficacy of dasatinib in a patient with nucleoporin 214-tyrosine protein kinase ABL1 proto-oncogene 1 (NUP214-ABL1)-positive early T-cell precursor-acute lymphoblastic leukemia (ETP-ALL), as well as that of selinexor and ..
  78. Somers K, Chudakova D, Middlemiss S, Wen V, Clifton M, Kwek A, et al. CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements. Oncotarget. 2016;7:46067-46087 pubmed publisher
    ..significantly decreased the viability of a subset of MLL-r and related leukemia cell lines with CALM-AF10 and SET-NUP214 translocation...
  79. Yang J, Bogerd H, Wang P, Page D, Cullen B. Two closely related human nuclear export factors utilize entirely distinct export pathways. Mol Cell. 2001;8:397-406 pubmed
    ..Thus, while the related TAP and NXF3 proteins are both capable of mediating nuclear RNA export, they do so via unrelated export pathways...
  80. Graux C, Stevens Kroef M, Lafage M, Dastugue N, Harrison C, Mugneret F, et al. Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia. Leukemia. 2009;23:125-33 pubmed publisher
    Episomes with the NUP214-ABL1 fusion gene have been observed in 6% of T-ALL. In this multicentric study we collected 27 cases of NUP214-ABL1-positive T-ALL. Median age was 15 years with male predominance. Outcome was poor in 12 patients...
  81. Schmitt C, von Kobbe C, Bachi A, Pante N, Rodrigues J, Boscheron C, et al. Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p. EMBO J. 1999;18:4332-47 pubmed
    ..we show that both the human and yeast proteins directly interact with an N-terminal region of the nucleoporins CAN/Nup159p...
  82. Crampton N, Kodiha M, Shrivastava S, Umar R, Stochaj U. Oxidative stress inhibits nuclear protein export by multiple mechanisms that target FG nucleoporins and Crm1. Mol Biol Cell. 2009;20:5106-16 pubmed publisher
    ..Furthermore, oxidative stress led to an increase in the apparent molecular masses of Nup98, Nup214, and Nup62...
  83. Bhattacharjya S, Roy K, Ganguly A, Sarkar S, Panda C, Bhattacharyya D, et al. Inhibition of nucleoporin member Nup214 expression by miR-133b perturbs mitotic timing and leads to cell death. Mol Cancer. 2015;14:42 pubmed publisher
    ..Here, we unveil a microRNA-mediated regulation of the nucleoporin Nup214 and its downstream effect on genome integrity...
  84. Sawada R, Doi H, Masataka N. Processing of self-related kinematic information embedded in static handwritten characters. Brain Res. 2016;1642:287-297 pubmed publisher
  85. Kandilci A, Mientjes E, Grosveld G. Effects of SET and SET-CAN on the differentiation of the human promonocytic cell line U937. Leukemia. 2004;18:337-40 pubmed
    Human SET encodes a nuclear phosphoprotein with a highly acidic carboxyl-terminus, forming a SET-CAN fusion gene in a patient with acute undifferentiated leukemia...
  86. Carman J, Nadler S. Direct association of tristetraprolin with the nucleoporin CAN/Nup214. Biochem Biophys Res Commun. 2004;315:445-9 pubmed
    ..One of the isolated TTP-interacting clones encoded the FG repeat region of the nuclear pore protein Nup214. Full length Nup214 co-precipitated with TTP from resting and LPS-stimulated THP-1 cells, indicating that this ..
  87. Kohler C, Tavelin B, Fan A, Radpour R, Barekati Z, Levi F, et al. Assessing the value of CAN-gene mutations using MALDI-TOF MS. J Cancer Res Clin Oncol. 2011;137:1239-44 pubmed publisher
    ..and Wood et al. performed a genome-wide mutation screening in human breast and colorectal cancers. 140 CAN-genes were found in breast cancer, which in turn contained overall 334 mutations...
  88. Wang B, Zhang X, Zhao Z. Validation-based insertional mutagenesis for identification of Nup214 as a host factor for EV71 replication in RD cells. Biochem Biophys Res Commun. 2013;437:452-6 pubmed publisher
    ..resistant to EV71, were produced using EV71 infection as a selection pressure and the nuclear pore protein 214 (Nup214) was identified as a host factor required for EV71 replication...
  89. Lindsay M, Holaska J, Welch K, Paschal B, Macara I. Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export. J Cell Biol. 2001;153:1391-402 pubmed
    ..the nucleus and the cytoplasm by a Crm1-dependent mechanism, and the Crm1--RanBP3-NES-Ran:GTP quarternary complex can associate with nucleoporins...
  90. Brownawell A, Macara I. Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins. J Cell Biol. 2002;156:53-64 pubmed
    ..We propose that exportin-5 is not an RNA export factor but instead participates in the regulated translocation of dsRBD proteins to the cytoplasm where they interact with target mRNAs. ..
  91. Clarke S, O Reilly J, Romeo G, Cooney J. NUP214-ABL1 positive T-cell acute lymphoblastic leukemia patient shows an initial favorable response to imatinib therapy post relapse. Leuk Res. 2011;35:e131-3 pubmed publisher