Gene Symbol: NUP160
Description: nucleoporin 160
Alias: nuclear pore complex protein Nup160, 160 kDa nucleoporin, nucleoporin 160kD, nucleoporin 160kDa, nucleoporin Nup160
Species: human
Products:     NUP160

Top Publications

  1. Belgareh N, Rabut G, Bai S, van Overbeek M, Beaudouin J, Daigle N, et al. An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. J Cell Biol. 2001;154:1147-60 pubmed
  2. Zuccolo M, Alves A, Galy V, Bolhy S, Formstecher E, Racine V, et al. The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions. EMBO J. 2007;26:1853-64 pubmed
    ..Together, our data thus provide the first molecular clues underlying the function of the human Nup107-160 complex at kinetochores. ..
  3. Vasu S, Shah S, Orjalo A, Park M, Fischer W, Forbes D. Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. J Cell Biol. 2001;155:339-54 pubmed
    ..Immunofluorescence reveals them to be new nucleoporins, designated Nup160 and Nup133, which are accessible on the basket side of the pore...
  4. Loiodice I, Alves A, Rabut G, Van Overbeek M, Ellenberg J, Sibarita J, et al. The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis. Mol Biol Cell. 2004;15:3333-44 pubmed
    ..Together, our results indicate that the entire Nup107-160 complex, which comprises nearly one-third of the so-far identified nucleoporins, specifically localizes to kinetochores in mitosis. ..
  5. Orjalo A, Arnaoutov A, Shen Z, Boyarchuk Y, Zeitlin S, Fontoura B, et al. The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly. Mol Biol Cell. 2006;17:3806-18 pubmed
    ..We conclude that the Nup107-160 complex is dynamic in mitosis and that it promotes spindle assembly in a manner that is distinct from its functions at interphase nuclear pores. ..
  6. Rasala B, Orjalo A, Shen Z, Briggs S, Forbes D. ELYS is a dual nucleoporin/kinetochore protein required for nuclear pore assembly and proper cell division. Proc Natl Acad Sci U S A. 2006;103:17801-6 pubmed
    ..Thus, we have identified an unexpected member of the nuclear pore and kinetochore that functions in both pore assembly at the nucleus and faithful cell division. ..
  7. Zhao F, Zhu J, Richman A, Fu Y, Huang W, Chen N, et al. Mutations in NUP160 Are Implicated in Steroid-Resistant Nephrotic Syndrome. J Am Soc Nephrol. 2019;: pubmed publisher
    ..The NUP160 gene, which encodes one of the protein components of the nuclear pore complex nucleoporin 160 kD (Nup160), is ..
  8. Ezzitouny M, Sánchez Lázaro I, Rivera M, Portoles Sanz M, Roselló Lletí E, Gil Cayuela C, et al. Molecular Alterations of Nucleocytoplasmic Transport in Patients on the Heart Transplantation Waiting List and Its Correlation With the Severity and Etiology of Heart Failure. Transplant Proc. 2019;51:369-371 pubmed publisher
    ..levels of IMPORTIN5 (IMP5); IMPORTINalpha2; ATPaseCaTransp (ATPCa); NUCLEOPORIN153kDa (Nup153); NUCLEOPORIN160kDa (Nup160); RANGTPaseAP1 (RanGAP1) and EXPORTIN4 (EXP4)...
  9. Braun D, Lovric S, Schapiro D, Schneider R, Marquez J, Asif M, et al. Mutations in multiple components of the nuclear pore complex cause nephrotic syndrome. J Clin Invest. 2018;128:4313-4328 pubmed publisher
    ..describe mutations in genes encoding 4 components of the outer rings of the NPC, namely NUP107, NUP85, NUP133, and NUP160, in 13 families with SRNS...

More Information


  1. Wang P, Zhao F, Nie X, Liu J, Yu Z. Knockdown of NUP160 inhibits cell proliferation, induces apoptosis, autophagy and cell migration, and alters the expression and localization of podocyte associated molecules in mouse podocytes. Gene. 2018;664:12-21 pubmed publisher
    ..The NUP160 gene is expressed in both human kidney and mouse kidney...
  2. Sawamura K, Maehara K, Keira Y, Ishikawa H, Sasamura T, Yamakawa T, et al. A test of double interspecific introgression of nucleoporin genes in Drosophila. G3 (Bethesda). 2014;4:2101-6 pubmed publisher
    ..simulans nucleoporin-encoding Nup96(sim) and Nup160(sim) can cause recessive lethality if the hybrid does not also inherit the D. simulans X chromosome...
  3. Hirai K, Wang Z, Miura K, Hayashi T, Awasaki T, Wada M, et al. Genetic Analyses of Elys Mutations in Drosophila Show Maternal-Effect Lethality and Interactions with Nucleoporin Genes. G3 (Bethesda). 2018;8:2421-2431 pubmed publisher
    ..The Nup160 introgression from D...
  4. Iwamoto M, Osakada H, Mori C, Fukuda Y, Nagao K, Obuse C, et al. Compositionally distinct nuclear pore complexes of functionally distinct dimorphic nuclei in the ciliate Tetrahymena. J Cell Sci. 2017;130:1822-1834 pubmed publisher
    ..Core members of the Nup107-Nup160 scaffold complex were enriched in MIC NPCs...
  5. Ryan K, White C, Patel K, Xu J, Olah M, Replogle J, et al. A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants. Sci Transl Med. 2017;9: pubmed publisher
    ..We found six loci (CD33, PILRB, NUP160, LRRK2, RGS1, and METTL21B) in which the risk haplotype drives the association with both ..
  6. Tang S, Presgraves D. Lineage-Specific Evolution of the Complex Nup160 Hybrid Incompatibility Between Drosophila melanogaster and Its Sister Species. Genetics. 2015;200:1245-54 pubmed publisher
    Two genes encoding protein components of the nuclear pore complex Nup160 and Nup96 cause lethality in F2-like hybrid genotypes between Drosophila simulans and Drosophila melanogaster. In particular, D...
  7. Nikolova V, Delimitreva S, Chakarova I, Zhivkova R, Hadzhinesheva V, Markova M. Dynamics of Lamins B and A/C and Nucleoporin Nup160 during Meiotic Maturation in Mouse Oocytes. Folia Biol (Praha). 2017;63:6-12 pubmed
    ..was aimed at elucidating the fate of three important nuclear envelope components - lamins B and A/C and nucleoporin Nup160, during meiotic maturation of mouse oocytes...
  8. Delay C, Grenier Boley B, Amouyel P, Dumont J, Lambert J. miRNA-dependent target regulation: functional characterization of single-nucleotide polymorphisms identified in genome-wide association studies of Alzheimer's disease. Alzheimers Res Ther. 2016;8:20 pubmed publisher
    ..The AD-associated rs9909-C allele in the 3'-UTR of NUP160 abolished the miR-1185-1-3p-regulated expression observed for the rs9909-G allele...
  9. Dong O, Meteignier L, Plourde M, Ahmed B, Wang M, Jensen C, et al. Arabidopsis TAF15b Localizes to RNA Processing Bodies and Contributes to snc1-Mediated Autoimmunity. Mol Plant Microbe Interact. 2016;29:247-57 pubmed publisher
    ..The Arabidopsis nuclear protein MOS11, along with the nucleoporins MOS3/Nup96/SAR3 and Nup160/SAR1 are components of the mRNA export machinery and contribute to immunity mediated by nucleotide binding leucine-..
  10. Leksa N, Brohawn S, Schwartz T. The structure of the scaffold nucleoporin Nup120 reveals a new and unexpected domain architecture. Structure. 2009;17:1082-91 pubmed publisher
    ..With the data presented here, we establish that all three branches of the Y-shaped Nup84 complex are tightly connected by helical interactions and that the beta-propellers likely form interaction site(s) to neighboring complexes. ..
  11. Mitchell J, Mansfeld J, Capitanio J, Kutay U, Wozniak R. Pom121 links two essential subcomplexes of the nuclear pore complex core to the membrane. J Cell Biol. 2010;191:505-21 pubmed publisher
    ..We show that key players mediating these interactions in mammalian cells are the nucleoporins Nup155 and Nup160. Nup155 depletion massively alters NE structure, causing a dramatic decrease in NPC numbers and the improper ..
  12. Hysi P, Cheng C, Springelkamp H, Macgregor S, Bailey J, Wojciechowski R, et al. Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma. Nat Genet. 2014;46:1126-1130 pubmed publisher
    ..2 (best P = 1.04 × 10(-11) for rs747782). Separate meta-analyses of 4 independent POAG cohorts, totaling 4,284 cases and 95,560 controls, showed that 3 of these loci for IOP were also associated with POAG. ..
  13. Kaur S, White T, DiGuilio A, Glavy J. The discovery of a Werner Helicase Interacting Protein (WHIP) association with the nuclear pore complex. Cell Cycle. 2010;9:3106-11 pubmed
    ..We thus identify WHIP as a partner/component of the NE/NPC and set forth to investigate a role for the protein positioned at the NPC...
  14. De Magistris P, Tatarek Nossol M, Dewor M, Antonin W. A self-inhibitory interaction within Nup155 and membrane binding are required for nuclear pore complex formation. J Cell Sci. 2018;131: pubmed publisher
    ..In vertebrates, the cytoplasmic and nucleoplasmic rings of NPCs are mostly formed by multiple copies of the Nup107-Nup160 complex, whereas the central, or inner ring is composed of Nup53, Nup93, Nup155 and the two paralogues Nup188 and ..
  15. Shimozono N, Jinnin M, Masuzawa M, Masuzawa M, Wang Z, Hirano A, et al. NUP160-SLC43A3 is a novel recurrent fusion oncogene in angiosarcoma. Cancer Res. 2015;75:4458-65 pubmed publisher
    ..issue by transcriptome sequencing of patient-derived angiosarcoma cells (ISO-HAS), identifying a novel fusion gene NUP160-SLC43A3 found to be expressed in 9 of 25 human angiosarcoma specimens that were examined...
  16. Mishra R, Chakraborty P, Arnaoutov A, Fontoura B, Dasso M. The Nup107-160 complex and gamma-TuRC regulate microtubule polymerization at kinetochores. Nat Cell Biol. 2010;12:164-9 pubmed publisher
  17. Zhu Y, Wang B, Tang K, Hsu C, Xie S, Du H, et al. An Arabidopsis Nucleoporin NUP85 modulates plant responses to ABA and salt stress. PLoS Genet. 2017;13:e1007124 pubmed publisher RD29A, COR15A and COR47 was significantly compromised in nup85 mutants and other nucleoporin mutants such as nup160 and hos1...
  18. Timani K, Liu Y, Suvannasankha A, He J. Regulation of ubiquitin-proteasome system-mediated Tip110 protein degradation by USP15. Int J Biochem Cell Biol. 2014;54:10-9 pubmed publisher
    ..Interestingly, USP15 knockdown restored hTip110 protein expression in Tg MEF and USP15 expression had little effects. Taken together, these results provide insights into the regulatory mechanism of human Tip110 degradation by USP15. ..
  19. Bilokapic S, Schwartz T. Molecular basis for Nup37 and ELY5/ELYS recruitment to the nuclear pore complex. Proc Natl Acad Sci U S A. 2012;109:15241-6 pubmed
    ..Finally, we propose an orientation of the Y-complex relative to the pore membrane, consistent with the lattice model...
  20. Morchoisne Bolhy S, Geoffroy M, Bouhlel I, Alves A, Audugé N, Baudin X, et al. Intranuclear dynamics of the Nup107-160 complex. Mol Biol Cell. 2015;26:2343-56 pubmed publisher
    ..Together our data uncover a previously neglected intranuclear pool of the Y-complex that may underscore a yet-uncharacterized function of these nucleoporins inside the nucleus, even in cells that contain no detectable GLFG bodies. ..
  21. Goeres J, Chan P, Mukhopadhyay D, Zhang H, Raught B, Matunis M. The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex. Mol Biol Cell. 2011;22:4868-82 pubmed publisher
    ..Disruption of these interactions enhances SENP2 substrate accessibility, suggesting an important regulatory node in the SUMO pathway...
  22. Glavy J, Krutchinsky A, Cristea I, Berke I, Boehmer T, Blobel G, et al. Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex. Proc Natl Acad Sci U S A. 2007;104:3811-6 pubmed
    ..within the complex, we used a comprehensive multiple-stage MS approach (MS, MS(2), and MS(3)), establishing that Nup160, Nup133, Nup96, and Nup107 are all targets of phosphorylation...
  23. Pandruvada S, Beauregard J, Benjannet S, Pata M, Lazure C, Seidah N, et al. Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking. Mol Cell Biol. 2016;36:507-21 pubmed publisher
    ..These Ostm1 molecular and cellular functions could elucidate all of the pathophysiologic mechanisms underlying the wide phenotypic spectrum of Ostm1-deficient mice. ..
  24. Platani M, Santarella Mellwig R, Posch M, Walczak R, Swedlow J, Mattaj I. The Nup107-160 nucleoporin complex promotes mitotic events via control of the localization state of the chromosome passenger complex. Mol Biol Cell. 2009;20:5260-75 pubmed publisher
    ..Our results indicate that a major function of the Nup107 complex in mitosis is to ensure the proper localization of the CPC at the centromere. ..