NUP153

Summary

Gene Symbol: NUP153
Description: nucleoporin 153
Alias: HNUP153, N153, nuclear pore complex protein Nup153, 153 kDa nucleoporin, nuclear pore complex protein hnup153, nucleoporin 153kD, nucleoporin 153kDa, nucleoporin Nup153
Species: human
Products:     NUP153

Top Publications

  1. Matreyek K, Engelman A. The requirement for nucleoporin NUP153 during human immunodeficiency virus type 1 infection is determined by the viral capsid. J Virol. 2011;85:7818-27 pubmed publisher
    ..RNA screens previously identified karyopherin ? transportin-3 (TNPO3) and NPC component nucleoporin 153 (NUP153) as being important for infection by human immunodeficiency virus type 1 (HIV-1)...
  2. Hase M, Cordes V. Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex. Mol Biol Cell. 2003;14:1923-40 pubmed
    ..with affinity-chromatography and yeast two-hybrid interaction studies, leading to the identification of nucleoporin Nup153 as the binding partner for Tpr...
  3. Woodward C, Prakobwanakit S, Mosessian S, Chow S. Integrase interacts with nucleoporin NUP153 to mediate the nuclear import of human immunodeficiency virus type 1. J Virol. 2009;83:6522-33 pubmed publisher
    ..Known binding partners of NUP153C competed with IN for binding with NUP153 and also inhibited the nuclear import of IN...
  4. Kutay U, Hartmann E, Treichel N, Calado A, Carmo Fonseca M, Prehn S, et al. Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. J Biol Chem. 2000;275:40163-8 pubmed
    ..Like the other members of the transport receptor superfamily, RanBP16 interacts with the nuclear pore complex and is able to enter the nucleus independent of energy and additional nuclear transport receptors. ..
  5. Matreyek K, Yücel S, Li X, Engelman A. Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity. PLoS Pathog. 2013;9:e1003693 pubmed publisher
    ..a direct interaction between the CA N-terminal domain and the phenylalanine-glycine (FG)-repeat enriched NUP153 C-terminal domain (NUP153(C))...
  6. Di Nunzio F. New insights in the role of nucleoporins: a bridge leading to concerted steps from HIV-1 nuclear entry until integration. Virus Res. 2013;178:187-96 pubmed publisher
    ..In particular, it will be reviewed both what is known and what is speculated about the link between HIV translocation through the nuclear pore and the proviral integration in the host chromatin. ..
  7. Koh Y, Wu X, Ferris A, Matreyek K, Smith S, Lee K, et al. Differential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integration. J Virol. 2013;87:648-58 pubmed publisher
    ..integration into gene-rich regions of chromosomes and gene bodies and reveals previously unrecognized roles for NUP153 (another HIV-1 cofactor implicated in viral nuclear import) and LEDGF/p75 in the targeting of the viral ..
  8. Bhattacharya A, Alam S, Fricke T, Zadrozny K, Sedzicki J, Taylor A, et al. Structural basis of HIV-1 capsid recognition by PF74 and CPSF6. Proc Natl Acad Sci U S A. 2014;111:18625-30 pubmed publisher
    ..as well as host proteins cleavage and polyadenylation specific factor 6 (CPSF6) and nucleoporin 153 kDa (NUP153), bind to the CA hexamer with at least 10-fold higher affinities compared with nonassembled CA or isolated CA ..
  9. Lee K, Ambrose Z, Martin T, Oztop I, Mulky A, Julias J, et al. Flexible use of nuclear import pathways by HIV-1. Cell Host Microbe. 2010;7:221-33 pubmed publisher
    ..Interestingly, whereas wild-type HIV-1 requires NUP153, N74D HIV-1 mimics feline immunodeficiency virus nuclear import requirements and is more sensitive to NUP155 ..

More Information

Publications77

  1. Rajanala K, Nandicoori V. Localization of nucleoporin Tpr to the nuclear pore complex is essential for Tpr mediated regulation of the export of unspliced RNA. PLoS ONE. 2012;7:e29921 pubmed publisher
    ..Results show that depletion of Nup153, a nucleoporin required for NPC anchoring of Tpr, plays a role in regulating the export, while depletion of other ..
  2. Krull S, Dörries J, Boysen B, Reidenbach S, Magnius L, Norder H, et al. Protein Tpr is required for establishing nuclear pore-associated zones of heterochromatin exclusion. EMBO J. 2010;29:1659-73 pubmed publisher
    ..These results assign a central function to Tpr as a determinant of perinuclear organization, with a direct role in forming a morphologically distinct nuclear sub-compartment and delimiting heterochromatin distribution. ..
  3. Price A, Jacques D, McEwan W, Fletcher A, Essig S, Chin J, et al. Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly. PLoS Pathog. 2014;10:e1004459 pubmed publisher
    ..interface formed exclusively within CA hexamers mediates binding to linear epitopes within cellular cofactors NUP153 and CPSF6, and is competed for by the antiretroviral compounds PF74 and BI-2...
  4. Ball J, Ullman K. Versatility at the nuclear pore complex: lessons learned from the nucleoporin Nup153. Chromosoma. 2005;114:319-30 pubmed
    The vertebrate pore protein Nup153 plays pivotal roles in nuclear pore function. In addition to being important to pore architecture, Nup153 is a key participant in both import and export...
  5. Mackay D, Elgort S, Ullman K. The nucleoporin Nup153 has separable roles in both early mitotic progression and the resolution of mitosis. Mol Biol Cell. 2009;20:1652-60 pubmed publisher
    ..Previous in vitro studies have suggested that the nuclear pore protein Nup153 is a good candidate for participating in mitotic coordination...
  6. Nakano H, Funasaka T, Hashizume C, Wong R. Nucleoporin translocated promoter region (Tpr) associates with dynein complex, preventing chromosome lagging formation during mitosis. J Biol Chem. 2010;285:10841-9 pubmed publisher
    ..Our data indicate that Tpr functions as a spatial and temporal regulator of spindle checkpoints, ensuring the efficient recruitment of checkpoint proteins to the molecular motor dynein to promote proper anaphase formation. ..
  7. Nakielny S, Shaikh S, Burke B, Dreyfuss G. Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain. EMBO J. 1999;18:1982-95 pubmed
    ..with an M9 nuclear localization sequence (NLS), and identified a short region within the N-terminus of the nucleoporin Nup153 which binds TRN1...
  8. Yokoyama N, Hayashi N, Seki T, Pante N, Ohba T, Nishii K, et al. A giant nucleopore protein that binds Ran/TC4. Nature. 1995;376:184-8 pubmed
    ..leucine-rich region, four RanBP1-homologous (refs 9, 10) domains, eight zinc-finger motifs similar to those of NUP153 (refs 11, 12), and a carboxy terminus with high homology to cyclophilin...
  9. Zhang H, Saitoh H, Matunis M. Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex. Mol Cell Biol. 2002;22:6498-508 pubmed
    ..The unique amino-terminal domain of SENP2 interacts with the FG repeat domain of Nup153, indicating that SENP2 associates with the nucleoplasmic basket of the NPC...
  10. Walther T, Fornerod M, Pickersgill H, Goldberg M, Allen T, Mattaj I. The nucleoporin Nup153 is required for nuclear pore basket formation, nuclear pore complex anchoring and import of a subset of nuclear proteins. EMBO J. 2001;20:5703-14 pubmed
    ..b>Nup153 is a peripheral NPC component that has been implicated in protein and RNP transport and in the interaction of NPCs ..
  11. Schaller T, Ocwieja K, Rasaiyaah J, Price A, Brady T, Roth S, et al. HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency. PLoS Pathog. 2011;7:e1002439 pubmed publisher
    ..Inhibition of CypA reduced dependence on Nup358 and the nuclear basket protein Nup153, suggesting that CypA regulates the choice of the nuclear import machinery that is engaged by the virus...
  12. Moroianu J, Blobel G, Radu A. RanGTP-mediated nuclear export of karyopherin alpha involves its interaction with the nucleoporin Nup153. Proc Natl Acad Sci U S A. 1997;94:9699-704 pubmed
    Using binding assays, we discovered an interaction between karyopherin alpha2 and the nucleoporin Nup153 and mapped their interacting domains...
  13. Xu L, Alarcon C, Cöl S, Massague J. Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import. J Biol Chem. 2003;278:42569-77 pubmed
  14. Pante N, Bastos R, McMorrow I, Burke B, Aebi U. Interactions and three-dimensional localization of a group of nuclear pore complex proteins. J Cell Biol. 1994;126:603-17 pubmed
    ..A monoclonal antibody, termed QE5, recognized three NPC polypeptides, p250, NUP153, and p62 on Western blots, and labeled the nuclear envelope of several cultured cell lines by immunofluorescence ..
  15. Higa M, Alam S, Sundquist W, Ullman K. Molecular characterization of the Ran-binding zinc finger domain of Nup153. J Biol Chem. 2007;282:17090-100 pubmed
    ..All four zinc fingers of human Nup153 were found to bind the small GTPase Ran with dissociation constants ranging between 5 and 40 mum...
  16. Zolotukhin A, Felber B. Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev. J Virol. 1999;73:120-7 pubmed
    ..First, we found that upon actinomycin D treatment, Nup98, but not Nup214 or Nup153, is able to translocate to the cytoplasm of HeLa cells, demonstrating that Nup98 may act as a soluble factor...
  17. Schmitz A, Schwarz A, Foss M, Zhou L, Rabe B, Hoellenriegel J, et al. Nucleoporin 153 arrests the nuclear import of hepatitis B virus capsids in the nuclear basket. PLoS Pathog. 2010;6:e1000741 pubmed publisher
    ..pull-down assays and partial siRNA depletion, we showed that HBV capsids directly interact with nucleoporin 153 (Nup153), an essential protein of the nuclear basket which participates in nuclear transport via importin beta...
  18. Griffis E, Craige B, Dimaano C, Ullman K, Powers M. Distinct functional domains within nucleoporins Nup153 and Nup98 mediate transcription-dependent mobility. Mol Biol Cell. 2004;15:1991-2002 pubmed
    ..We have extended our studies of dynamics to include Nup153, another mobile nucleoporin implicated in RNA export...
  19. Hang J, Dasso M. Association of the human SUMO-1 protease SENP2 with the nuclear pore. J Biol Chem. 2002;277:19961-6 pubmed
    ..We have also shown that SENP2 binds to Nup153, a nucleoporin that is localized to the nucleoplasmic face of the pore...
  20. Herold A, Suyama M, Rodrigues J, Braun I, Kutay U, Carmo Fonseca M, et al. TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. Mol Cell Biol. 2000;20:8996-9008 pubmed
    ..Both human p15 homologues bind TAP, NXF2, and NXF3. Together, our results indicate that the TAP-p15 mRNA export pathway has diversified in higher eukaryotes compared to yeast, perhaps reflecting a greater substrate complexity. ..
  21. Di Nunzio F, Fricke T, Miccio A, Valle Casuso J, Perez P, Souque P, et al. Nup153 and Nup98 bind the HIV-1 core and contribute to the early steps of HIV-1 replication. Virology. 2013;440:8-18 pubmed publisher
    ..In the current work, we studied the role of nucleoporins 153 and 98 (Nup153 and Nup98) in infection of human Jurkat lymphocytes by HIV-1...
  22. Mamede J, Sitbon M, Battini J, Courgnaud V. Heterogeneous susceptibility of circulating SIV isolate capsids to HIV-interacting factors. Retrovirology. 2013;10:77 pubmed publisher
    ..e. TRIM5 proteins) and facilitating (i.e. cyclophilin A and nucleopore-associated Nup358/RanBP2 and Nup153) factors in single-round infectivity assays that reproduce early stages of the viral life-cycle...
  23. Ben Efraim I, Gerace L. Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import. J Cell Biol. 2001;152:411-7 pubmed
    ..binding analysis to determine the affinity of an importin beta cargo complex for Nup358, the Nup62 complex, and Nup153, which are in the cytoplasmic, central, and nucleoplasmic regions of the NPC, respectively...
  24. Bachi A, Braun I, Rodrigues J, Pante N, Ribbeck K, von Kobbe C, et al. The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates. RNA. 2000;6:136-58 pubmed
    ..TAP interacts with multiple components of the NPC including the nucleoporins CAN, Nup98, Nup153, p62, and with three major NPC subcomplexes. The nucleoporin-binding domain of TAP comprises residues 508-619...
  25. Frosst P, Guan T, Subauste C, Hahn K, Gerace L. Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export. J Cell Biol. 2002;156:617-30 pubmed
    ..that mammalian Tpr is concentrated within the nuclear basket of the pore complex in a distribution similar to Nup153 and Nup98...
  26. Krull S, Thyberg J, Bjorkroth B, Rackwitz H, Cordes V. Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket. Mol Biol Cell. 2004;15:4261-77 pubmed
    ..human NPC proteins relative to the NPC core and its associated basket, including Nup93, Nup96, Nup98, Nup107, Nup153, Nup205, and the coiled coil-dominated 267-kDa protein Tpr...
  27. Ullman K, Shah S, Powers M, Forbes D. The nucleoporin nup153 plays a critical role in multiple types of nuclear export. Mol Biol Cell. 1999;10:649-64 pubmed
    ..At present, Nup153 is the only nucleoporin known to localize to the surface of this basket, suggesting that Nup153 is potentially one ..
  28. Zhong H, Takeda A, Nazari R, Shio H, Blobel G, Yaseen N. Carrier-independent nuclear import of the transcription factor PU.1 via RanGTP-stimulated binding to Nup153. J Biol Chem. 2005;280:10675-82 pubmed
    ..PU.1 interacted directly with two nucleoporins, Nup62 and Nup153. The binding of PU...
  29. Sistla S, Pang J, Wang C, Balasundaram D. Multiple conserved domains of the nucleoporin Nup124p and its orthologs Nup1p and Nup153 are critical for nuclear import and activity of the fission yeast Tf1 retrotransposon. Mol Biol Cell. 2007;18:3692-708 pubmed
    ..The human nucleoporin Nup153 and the Saccharomyces cerevisiae Nup1p were identified as orthologs of Nup124p...
  30. Lim R, Fahrenkrog B, Köser J, Schwarz Herion K, Deng J, Aebi U. Nanomechanical basis of selective gating by the nuclear pore complex. Science. 2007;318:640-3 pubmed
    ..that binding interactions with the transport receptor karyopherin-beta1 caused the FG domains of the human nucleoporin Nup153 to collapse into compact molecular conformations...
  31. Rodriguez M, Yu X, Chen J, Songyang Z. Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains. J Biol Chem. 2003;278:52914-8 pubmed
    ..Structural analysis of BRCA1 BRCT repeats also predicted conserved residues that may form the phosphopeptide-binding pocket. Thus, the BRCT repeats are a new family of phosphopeptide-binding domains in DNA damage responses. ..
  32. Kim N, Pham N, Quinn R, Shim J, Cho H, Cho S, et al. The Small Molecule R-(-)-β-O-Methylsynephrine Binds to Nucleoporin 153 kDa and Inhibits Angiogenesis. Int J Biol Sci. 2015;11:1088-99 pubmed publisher
    ..to isolate potential OMe-Syn binding proteins from human cDNA libraries and identified nucleoporin 153 kDa (NUP153) as a primary binding partner of OMe-Syn...
  33. Wong R, Mamede J, Hope T. Impact of Nucleoporin-Mediated Chromatin Localization and Nuclear Architecture on HIV Integration Site Selection. J Virol. 2015;89:9702-5 pubmed publisher
    ..Here, we describe the link between the nuclear basket nucleoporins (Tpr and Nup153) and chromatin organization and how altering the host environment by manipulating nuclear structure may have ..
  34. Hilditch L, Towers G. A model for cofactor use during HIV-1 reverse transcription and nuclear entry. Curr Opin Virol. 2014;4:32-6 pubmed publisher
  35. Kuersten S, Arts G, Walther T, Englmeier L, Mattaj I. Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains. Mol Cell Biol. 2002;22:5708-20 pubmed
    ..The N terminus binds to both Nup153 and RanBP2/Nup358 in a RanGTP-dependent manner, while the C terminus binds to CAN/Nup214 independently of Ran...
  36. Shain A, Salari K, Giacomini C, Pollack J. Integrative genomic and functional profiling of the pancreatic cancer genome. BMC Genomics. 2013;14:624 pubmed publisher
    ..Most notably, the analysis also revealed novel possible oncogenic functions of nucleoporin NUP153 (ostensibly by modulating TGFβ signaling) and Kruppel-like transcription factor KLF5 in pancreatic cancer...
  37. Ando Y, Tomaru Y, Morinaga A, Burroughs A, Kawaji H, Kubosaki A, et al. Nuclear pore complex protein mediated nuclear localization of dicer protein in human cells. PLoS ONE. 2011;6:e23385 pubmed publisher
    ..We also find that human DICER1 protein associates with the NUP153 protein, one component of the nuclear pore complex...
  38. Woodward C, Chow S. The nuclear pore complex: a new dynamic in HIV-1 replication. Nucleus. 2010;1:18-22 pubmed publisher
    ..We have recently reported a functional role for the nucleoporin NUP153 in the nuclear import of the HIV-1 preintegration complex (PIC)...
  39. Adam S. The nuclear pore complex. Genome Biol. 2001;2:REVIEWS0007 pubmed
  40. Toda T, Hsu J, Linker S, Hu L, Schäfer S, Mertens J, et al. Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells. Cell Stem Cell. 2017;21:618-634.e7 pubmed publisher
    ..Here we show that the nucleoporin Nup153 interacts with Sox2 in adult NeuPCs, where it is indispensable for their maintenance and controls neuronal ..
  41. Rani A, Dhillon A, Sharma K, Goyal A. Insights into the structural characteristics and substrate binding analysis of chondroitin AC lyase (PsPL8A) from Pedobacter saltans. Int J Biol Macromol. 2018;109:980-991 pubmed publisher
    ..Structural superposition and docking analysis showed, N153, W105, H203, Y208, Y212, R266 and E349 were involved in catalysis...
  42. de Castro I, Budzak J, Di Giacinto M, Ligammari L, Gokhan E, Spanos C, et al. Repo-Man/PP1 regulates heterochromatin formation in interphase. Nat Commun. 2017;8:14048 pubmed publisher
    ..Here we show that Repo-Man, via Nup153, is enriched on condensed chromatin at the nuclear periphery and at the edge of the nucleopore basket...
  43. Saito A, Henning M, Serrao E, Dubose B, Teng S, Huang J, et al. Capsid-CPSF6 Interaction Is Dispensable for HIV-1 Replication in Primary Cells but Is Selected during Virus Passage In Vivo. J Virol. 2016;90:6918-6935 pubmed publisher
    ..The A77V mutation rendered HIV-1 largely independent from TNPO3, NUP358, and NUP153 for infection and altered the integration site preference of HIV-1 without any discernible effects during the late ..
  44. Deniset J, Hedley T, Hlaváčková M, Chahine M, Dibrov E, O Hara K, et al. Heat shock protein 60 involvement in vascular smooth muscle cell proliferation. Cell Signal. 2018;47:44-51 pubmed publisher
    ..AdHsp60 treatment also induced increases in nucleoporin (Nup) 62, Nup153, importin-?, importin-? and Ran expression as well as cellular ATP levels compared to control...
  45. Datta S, Chowdhury A, Ghosh M, Das K, Jha P, Colah R, et al. A genome-wide search for non-UGT1A1 markers associated with unconjugated bilirubin level reveals significant association with a polymorphic marker near a gene of the nucleoporin family. Ann Hum Genet. 2012;76:33-41 pubmed publisher
    ..A significant association of a polymorphic marker (rs2328136) near the NUP153 gene (which produces a 153 kDa nucleoporin) was obtained (p = 0.002, after multiple-testing correction)...
  46. Milles S, Huy Bui K, Koehler C, Eltsov M, Beck M, Lemke E. Facilitated aggregation of FG nucleoporins under molecular crowding conditions. EMBO Rep. 2013;14:178-83 pubmed publisher
    ..The superb spatial resolving power of EM also reveals that hydrogels are enlaced amyloid fibres, and these findings have implications for existing transport models and for NPC assembly. ..
  47. Pérez Garrastachu M, Arluzea J, Andrade R, Díez Torre A, Urtizberea M, Silio M, et al. Nucleoporins redistribute inside the nucleus after cell cycle arrest induced by histone deacetylases inhibition. Nucleus. 2017;8:515-533 pubmed publisher
    ..In particular, the nuclear basket proteins Tpr and Nup153, and the FG-nucleoporin Nup98 seem to play key roles in all these novel functions...
  48. Gustin K, Sarnow P. Inhibition of nuclear import and alteration of nuclear pore complex composition by rhinovirus. J Virol. 2002;76:8787-96 pubmed
    ..of cellular proteins and inhibition of nuclear import correlated with the degradation of two NPC components, Nup153 and p62...
  49. Onder Z, Moroianu J. Nuclear import of cutaneous beta genus HPV8 E7 oncoprotein is mediated by hydrophobic interactions between its zinc-binding domain and FG nucleoporins. Virology. 2014;449:150-62 pubmed publisher
    ..for the nuclear import and localization of HPV8 E7 via hydrophobic interactions with the FG nucleoporins Nup62 and Nup153. Substitution of the hydrophobic residues within the 65LRLFV69 patch to alanines, and not R66A mutation, disrupt ..
  50. Goff S. Knockdown screens to knockout HIV-1. Cell. 2008;135:417-20 pubmed publisher
    ..Although some caveats remain, this screening approach opens up a new landscape of viral-host interactions for future exploration. ..
  51. Tan W, Zolotukhin A, Bear J, Patenaude D, Felber B. The mRNA export in Caenorhabditis elegans is mediated by Ce-NXF-1, an ortholog of human TAP/NXF and Saccharomyces cerevisiae Mex67p. RNA. 2000;6:1762-72 pubmed
    ..This region was shown to interact with the FG-repeat domains of nucleoporins Nup98, Nup153, and Nup214, indicating that the rim association occurs through components of the nuclear pore complex...
  52. Zhou L, Pante N. The nucleoporin Nup153 maintains nuclear envelope architecture and is required for cell migration in tumor cells. FEBS Lett. 2010;584:3013-20 pubmed publisher
    Nucleoporin 153 (Nup153), a component of the nuclear pore complex (NPC), has been implicated in the interaction of the NPC with the nuclear lamina...
  53. Schmitt I, Gerace L. In vitro analysis of nuclear transport mediated by the C-terminal shuttle domain of Tap. J Biol Chem. 2001;276:42355-63 pubmed
    ..export receptor CRM1 competes with the Tap transport domain for binding to Nup214 but not for binding to Nup62 or Nup153, suggesting that the Tap and CRM1 nuclear export pathways converge at the cytoplasmic periphery of the nuclear ..
  54. Walther T, Askjaer P, Gentzel M, Habermann A, Griffiths G, Wilm M, et al. RanGTP mediates nuclear pore complex assembly. Nature. 2003;424:689-94 pubmed
    ..Here we demonstrate that RanGTP production is required to dissociate nucleoporins Nup107, Nup153 and Nup358 from Importin beta, to target them to chromatin and to induce association between separate NPC ..
  55. Xu L, Kang Y, Cöl S, Massague J. Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus. Mol Cell. 2002;10:271-82 pubmed
    ..We uncovered direct interactions of Smad2 with the nucleoporins CAN/Nup214 and Nup153. These interactions mediate constitutive nucleocytoplasmic shuttling of Smad2...
  56. Mackay D, Howa A, Werner T, Ullman K. Nup153 and Nup50 promote recruitment of 53BP1 to DNA repair foci by antagonizing BRCA1-dependent events. J Cell Sci. 2017;130:3347-3359 pubmed publisher
    ..The nucleoporin Nup153 has been implicated in the DNA damage response, attributed to a role in promoting nuclear import of 53BP1...
  57. Kapinos L, Schoch R, Wagner R, Schleicher K, Lim R. Karyopherin-centric control of nuclear pores based on molecular occupancy and kinetic analysis of multivalent binding with FG nucleoporins. Biophys J. 2014;106:1751-62 pubmed publisher
    ..A general feature of the FxFG domains of Nup214, Nup62, and Nup153 is their capacity to extend and accommodate large numbers of Kapβ1 molecules at physiological Kapβ1 ..
  58. Lemaitre C, Fischer B, Kalousi A, Hoffbeck A, Guirouilh Barbat J, Shahar O, et al. The nucleoporin 153, a novel factor in double-strand break repair and DNA damage response. Oncogene. 2012;31:4803-9 pubmed publisher
    ..Here, we show that the human nucleoporin 153 (NUP153) has a role in repair of DSBs and in the activation of DNA damage checkpoints...
  59. Vollmer B, Lorenz M, Moreno Andrés D, Bodenhöfer M, De Magistris P, Astrinidis S, et al. Nup153 Recruits the Nup107-160 Complex to the Inner Nuclear Membrane for Interphasic Nuclear Pore Complex Assembly. Dev Cell. 2015;33:717-28 pubmed publisher
    ..Here, we show that the nucleoporin Nup153 is required for NPC assembly during interphase but not during mitotic exit...
  60. Kvaratskhelia M, Sharma A, Larue R, Serrao E, Engelman A. Molecular mechanisms of retroviral integration site selection. Nucleic Acids Res. 2014;42:10209-25 pubmed publisher
    ..We discuss approaches to alter integration site selection that could potentially improve the safety of retroviral vectors in the clinic. ..
  61. Chen N, Zhou L, Gane P, Opp S, Ball N, Nicastro G, et al. HIV-1 capsid is involved in post-nuclear entry steps. Retrovirology. 2016;13:28 pubmed publisher
    ..Depletion of Nup153, a nucleoporin located at the nuclear side of the nuclear pore that binds to HIV-1 capsid, made the virus less ..
  62. Moroianu J. Nuclear import and export pathways. J Cell Biochem. 1999;Suppl 32-33:76-83 pubmed
    ..One of the challenges for the future will be to establish the mechanisms of translocation through the NPC of different transport receptors together with their cargoes. J. Cell. Biochem. Suppls. 32/33:76-83, 1999. ..
  63. Otsuka S, Iwasaka S, Yoneda Y, Takeyasu K, Yoshimura S. Individual binding pockets of importin-beta for FG-nucleoporins have different binding properties and different sensitivities to RanGTP. Proc Natl Acad Sci U S A. 2008;105:16101-6 pubmed publisher
    ..pockets demonstrate that the individual FG-binding pockets have different affinities to FG-Nups (Nup62 and Nup153) and different sensitivities to RanGTP; the binding of RanGTP to the amino-terminal domain of importin-beta ..
  64. Taltynov O, Desimmie B, Demeulemeester J, Christ F, Debyser Z. Cellular cofactors of lentiviral integrase: from target validation to drug discovery. Mol Biol Int. 2012;2012:863405 pubmed publisher
    ..Finally, we will highlight recent advances in the design and the development of small-molecule inhibitors binding to the LEDGF/p75-binding pocket in IN (LEDGINs). ..
  65. Makise M, Mackay D, Elgort S, Shankaran S, Adam S, Ullman K. The Nup153-Nup50 protein interface and its role in nuclear import. J Biol Chem. 2012;287:38515-22 pubmed publisher
    ..b>Nup153 is the nucleoporin that provides this scaffold for Nup50...
  66. Yaseen N, Blobel G. Cloning and characterization of human karyopherin beta3. Proc Natl Acad Sci U S A. 1997;94:4451-6 pubmed
    ..It bound to several of the repeat-containing nucleoporins (Nup358, Nup214, Nup153, Nup98, and p62) in overlay and solution-binding assays and was competed away by karyopherin beta1...
  67. Moudry P, Lukas C, Macurek L, Neumann B, Hériché J, Pepperkok R, et al. Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1. Cell Death Differ. 2012;19:798-807 pubmed publisher
    ..resource, and validate and functionally characterize one of the identified 'hits': a nuclear pore component NUP153 as a novel factor specifically required for 53BP1 nuclear import...
  68. Dimaano C, Ball J, Prunuske A, Ullman K. RNA association defines a functionally conserved domain in the nuclear pore protein Nup153. J Biol Chem. 2001;276:45349-57 pubmed
    ..One such protein, the nucleoporin Nup153, is localized to the nuclear basket of the pore complex and has been shown to be a central component of the ..