NUP107

Summary

Gene Symbol: NUP107
Description: nucleoporin 107
Alias: NPHS11, NUP84, nuclear pore complex protein Nup107, nucleoporin 107kDa
Species: human
Products:     NUP107

Top Publications

  1. Walther T, Alves A, Pickersgill H, Loiodice I, Hetzer M, Galy V, et al. The conserved Nup107-160 complex is critical for nuclear pore complex assembly. Cell. 2003;113:195-206 pubmed
    ..We demonstrate a function for the conserved Nup107-160 complex in this process...
  2. Loiodice I, Alves A, Rabut G, Van Overbeek M, Ellenberg J, Sibarita J, et al. The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis. Mol Biol Cell. 2004;15:3333-44 pubmed
    ..One such building block of the NPC, termed the Nup107-160 complex in vertebrates, was so far demonstrated to be composed of six different nucleoporins...
  3. Zuccolo M, Alves A, Galy V, Bolhy S, Formstecher E, Racine V, et al. The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions. EMBO J. 2007;26:1853-64 pubmed
    We previously demonstrated that a fraction of the human Nup107-160 nuclear pore subcomplex is recruited to kinetochores at the onset of mitosis...
  4. Orjalo A, Arnaoutov A, Shen Z, Boyarchuk Y, Zeitlin S, Fontoura B, et al. The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly. Mol Biol Cell. 2006;17:3806-18 pubmed
    The Nup107-160 complex is a critical subunit of the nuclear pore. This complex localizes to kinetochores in mitotic mammalian cells, where its function is unknown...
  5. Boehmer T, Enninga J, Dales S, Blobel G, Zhong H. Depletion of a single nucleoporin, Nup107, prevents the assembly of a subset of nucleoporins into the nuclear pore complex. Proc Natl Acad Sci U S A. 2003;100:981-5 pubmed
    ..We used transfection of HeLa cells with small interfering RNAs to specifically deplete mRNA for Nup107. In a domino effect, Nup107 depletion caused codepletion of a subset of other Nups on their protein but not on ..
  6. Belgareh N, Rabut G, Bai S, van Overbeek M, Beaudouin J, Daigle N, et al. An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. J Cell Biol. 2001;154:1147-60 pubmed
    ..experiments revealed a direct and evolutionarily conserved interaction between Nup133 and Nup84/Nup107 and indicated that hNup133 and hNup107 are part of a NPC subcomplex that contains two other nucleoporins (the ..
  7. Kim S, Fernandez Martinez J, Sampathkumar P, Martel A, Matsui T, Tsuruta H, et al. Integrative structure-function mapping of the nucleoporin Nup133 suggests a conserved mechanism for membrane anchoring of the nuclear pore complex. Mol Cell Proteomics. 2014;13:2911-26 pubmed publisher
    ..Nup133, a major component in the essential Y-shaped Nup84 complex, is a large scaffold protein of the NPC's outer ring structure...
  8. Cianciolo Cosentino C, Berto A, Pelletier S, Hari M, Loffing J, Neuhauss S, et al. Moderate Nucleoporin 133 deficiency leads to glomerular damage in zebrafish. Sci Rep. 2019;9:4750 pubmed publisher
    ..In particular, previous genetic studies of patients with nephrotic syndrome identified mutations in Nup107 that impaired the expression or the localization of its direct partner at nuclear pores, Nup133...
  9. Nagy V, Hsia K, Debler E, Kampmann M, Davenport A, Blobel G, et al. Structure of a trimeric nucleoporin complex reveals alternate oligomerization states. Proc Natl Acad Sci U S A. 2009;106:17693-8 pubmed publisher
    The heptameric Nup84 complex constitutes an evolutionarily conserved building block of the nuclear pore complex...

More Information

Publications67

  1. Seo H, Ma Y, Debler E, Wacker D, Kutik S, Blobel G, et al. Structural and functional analysis of Nup120 suggests ring formation of the Nup84 complex. Proc Natl Acad Sci U S A. 2009;106:14281-6 pubmed publisher
    The Nup84 complex constitutes a key building block in the nuclear pore complex (NPC)...
  2. Mehsen H, Boudreau V, Garrido D, Bourouh M, Larouche M, Maddox P, et al. PP2A-B55 promotes nuclear envelope reformation after mitosis in Drosophila. J Cell Biol. 2018;217:4106-4123 pubmed publisher
    ..exit by dephosphorylating BAF and suggests that PP2A-Tws targets additional NE components, including Lamin and Nup107. This work establishes Drosophila as a powerful model to further dissect the molecular mechanisms of NER ..
  3. Alazami A, Patel N, Shamseldin H, Anazi S, Al Dosari M, Alzahrani F, et al. Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families. Cell Rep. 2015;10:148-61 pubmed publisher
    ..TAF6, TBCK, FAM177A1, KIAA1109, MTSS1L, XIRP1, KCTD3, CHAF1B, ARV1, ISCA2, PTRH2, GEMIN4, MYOCD, PDPR, DPH1, NUP107, TMEM92, EPB41L4A, and FAM120AOS)...
  4. Bonnet A, Bretes H, Palancade B. Nuclear pore components affect distinct stages of intron-containing gene expression. Nucleic Acids Res. 2015;43:4249-61 pubmed publisher
    ..Ulp1, whose maintenance at nuclear pores depends on the Nup84 complex, impacts on THO-dependent gene expression, whereas the nuclear basket-associated Mlp1/Pml39 proteins ..
  5. Shi Y, Fernandez Martinez J, Tjioe E, Pellarin R, Kim S, Williams R, et al. Structural characterization by cross-linking reveals the detailed architecture of a coatomer-related heptameric module from the nuclear pore complex. Mol Cell Proteomics. 2014;13:2927-43 pubmed publisher
    ..We applied this integrative strategy to determine the structure of the native Nup84 complex, a stable hetero-heptameric assembly (∼ 600 kDa), 16 copies of which form the outer rings of the 50-..
  6. Lau C, Delmar V, Chan R, Phung Q, Bernis C, Fichtman B, et al. Transportin regulates major mitotic assembly events: from spindle to nuclear pore assembly. Mol Biol Cell. 2009;20:4043-58 pubmed publisher
    ..the nucleoporin subunit targets for transportin and importin beta and find them to be largely the same: ELYS, the Nup107/160 complex, Nup53, and the FG nucleoporins...
  7. Platani M, Samejima I, Samejima K, Kanemaki M, Earnshaw W. Seh1 targets GATOR2 and Nup153 to mitotic chromosomes. J Cell Sci. 2018;131: pubmed publisher
    In metazoa, the Nup107 complex (also known as the nucleoporin Y-complex) plays a major role in formation of the nuclear pore complex in interphase and is localised to kinetochores in mitosis...
  8. Su X, Dion V, Gasser S, Freudenreich C. Regulation of recombination at yeast nuclear pores controls repair and triplet repeat stability. Genes Dev. 2015;29:1006-17 pubmed publisher
    ..Relocation requires Nup84 and the Slx5/8 SUMO-dependent ubiquitin ligase but not Rad51, Mec1, or Tel1...
  9. Schwartz M, Travesa A, Martell S, Forbes D. Analysis of the initiation of nuclear pore assembly by ectopically targeting nucleoporins to chromatin. Nucleus. 2015;6:40-54 pubmed publisher
    ..Strikingly, Nup133 and Nup107 of the Nup107/160 subcomplex and Nup153 and Nup50 of the nuclear pore basket recruited a near full complement of ..
  10. Sachani S, Landschoot L, Zhang L, White C, MacDonald W, Golding M, et al. Nucleoporin 107, 62 and 153 mediate Kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cells. Nat Commun. 2018;9:2795 pubmed publisher
    ..Multiple factors are identified, including nucleoporin 107 (NUP107)...
  11. Hirai K, Wang Z, Miura K, Hayashi T, Awasaki T, Wada M, et al. Genetic Analyses of Elys Mutations in Drosophila Show Maternal-Effect Lethality and Interactions with Nucleoporin Genes. G3 (Bethesda). 2018;8:2421-2431 pubmed publisher
    ..Our genetic experiments indicated critical interactions between ELYS and three Nup107-160 subcomplex components; hemizygotes of either Nup37, Nup96 or Nup160 were lethal in the ..
  12. Rotem A, Gruber R, Shorer H, Shaulov L, Klein E, Harel A. Importin beta regulates the seeding of chromatin with initiation sites for nuclear pore assembly. Mol Biol Cell. 2009;20:4031-42 pubmed publisher
    ..The first step in postmitotic NPC assembly involves the "seeding" of chromatin with ELYS and the Nup107-160 complex...
  13. Hayashi D, Tanabe K, Katsube H, Inoue Y. B-type nuclear lamin and the nuclear pore complex Nup107-160 influences maintenance of the spindle envelope required for cytokinesis in Drosophila male meiosis. Biol Open. 2016;5:1011-21 pubmed publisher
    ..Among the nuclear pore complex proteins, Nup107 co-localized with Lam during this meiotic division...
  14. An H, Lee H, Jang S, Jung Y, Choi S, Park S, et al. Transcription factor Sp1 prevents TRF2(ΔBΔM)-induced premature senescence in human diploid fibroblasts. Mol Cell Biochem. 2016;414:201-8 pubmed publisher
    ..Among transcriptional targets of Sp1, expression levels of nuclear transport genes such as karyopherin α, Nup107, and Nup50 were down-regulated in the TRF2(ΔBΔM)-induced senescence, which was prevented by Sp1 ..
  15. Shang J, Yamashita T, Nakano Y, Morihara R, Li X, Feng T, et al. Aberrant distributions of nuclear pore complex proteins in ALS mice and ALS patients. Neuroscience. 2017;350:158-168 pubmed publisher
    ..we investigated the spatiotemporal distributions of RanGAP1 and 4 representative nucleoporins (GP210, NUP205, NUP107 and NUP50) of NPCs in human Cu/Zn superoxide dismutase-1 mutation transgenic (SOD1-Tg) mice and sporadic ALS ..
  16. Finan K, Raulf A, Heilemann M. A set of homo-oligomeric standards allows accurate protein counting. Angew Chem Int Ed Engl. 2015;54:12049-52 pubmed publisher
    ..The utility of these standards was demonstrated by showing that nuclear pores contain 32 copies of the Nup107 complex.
  17. Chung D, Chan J, Strecker J, Zhang W, Ebrahimi Ardebili S, Lu T, et al. Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process. Nat Commun. 2015;6:7742 pubmed publisher
    ..Cik1-Kar3) cooperates with chromatin remodellers to mediate interactions between subtelomeric DSBs and the Nup84 nuclear pore complex to ensure cell survival via break-induced replication (BIR), an error-prone DNA repair ..
  18. Ren Y, Diao F, Katari S, Yatsenko S, Jiang H, Wood Trageser M, et al. Functional study of a novel missense single-nucleotide variant of NUP107 in two daughters of Mexican origin with premature ovarian insufficiency. Mol Genet Genomic Med. 2018;6:276-281 pubmed publisher
    ..Most cases of HH are idiopathic and nonsyndromic. Nucleoporin 107 (NUP107), a protein involved in transport between cytoplasm and nucleus with putative roles in meiosis/mitosis progression,..
  19. Iwamoto M, Osakada H, Mori C, Fukuda Y, Nagao K, Obuse C, et al. Compositionally distinct nuclear pore complexes of functionally distinct dimorphic nuclei in the ciliate Tetrahymena. J Cell Sci. 2017;130:1822-1834 pubmed publisher
    ..Core members of the Nup107-Nup160 scaffold complex were enriched in MIC NPCs...
  20. Niño C, Guet D, Gay A, Brutus S, Jourquin F, Mendiratta S, et al. Posttranslational marks control architectural and functional plasticity of the nuclear pore complex basket. J Cell Biol. 2016;212:167-80 pubmed publisher
    ..in regulating the association dynamics of Nup60 and its partner, Nup2, with the NPC through an interaction with Nup84, a component of the Y complex...
  21. Gu Y, Liu Y, Cao S, Huang X, Zuo Z, Yu S, et al. Suppressive subtractive hybridization reveals different gene expression between high and low virulence strains of Cladosporium cladosporioides. Microb Pathog. 2016;100:276-284 pubmed publisher
    ..significantly different between Z20 and Zt strains, while genes encoding the senescence-associated proteins, pse1, nup107, mip1, pex2, icl1 and ?/? hydrolase exhibited no significant differences between the two strains...
  22. Xu C, Li Z, He H, Wernimont A, Li Y, Loppnau P, et al. Crystal structure of human nuclear pore complex component NUP43. FEBS Lett. 2015;589:3247-53 pubmed publisher
    ..We solved the crystal structure of human Nup43 (hNUP43), an important component in the Nup107 subcomplex of NPC. hNup43 adopts a seven-bladed β-propeller fold...
  23. Fernandez Martinez J, Kim S, Shi Y, Upla P, Pellarin R, Gagnon M, et al. Structure and Function of the Nuclear Pore Complex Cytoplasmic mRNA Export Platform. Cell. 2016;167:1215-1228.e25 pubmed publisher
    ..The Nup82 complex fits into the NPC through the outer ring Nup84 complex...
  24. Gómez Saldivar G, Fernandez A, Hirano Y, Mauro M, Lai A, Ayuso C, et al. Identification of Conserved MEL-28/ELYS Domains with Essential Roles in Nuclear Assembly and Chromosome Segregation. PLoS Genet. 2016;12:e1006131 pubmed publisher
    ..The nucleoporin MEL-28/ELYS plays a critical role in post-mitotic NPC reassembly through recruitment of the NUP107-160 subcomplex, and is required for correct segregation of mitotic chromosomes...
  25. Vollmer B, Lorenz M, Moreno Andrés D, Bodenhöfer M, De Magistris P, Astrinidis S, et al. Nup153 Recruits the Nup107-160 Complex to the Inner Nuclear Membrane for Interphasic Nuclear Pore Complex Assembly. Dev Cell. 2015;33:717-28 pubmed publisher
    ..This binding facilitates the recruitment of the Nup107-160 complex, a crucial structural component of the NPC, to assembly sites...
  26. Zhang H, Ye J, Weng X, Liu F, He L, Zhou D, et al. Comparative transcriptome analysis reveals that the extracellular matrix receptor interaction contributes to the venous metastases of hepatocellular carcinoma. Cancer Genet. 2015;208:482-91 pubmed publisher
    ..identified five common fusion genes between HCC and its corresponding PVTT samples, including ARID1A-GPATCH3, MDM1-NUP107, PTGES3-RARG, PRLR-TERT, and C9orf3-TMC1...
  27. Rosti R, Sotak B, Bielas S, Bhat G, Silhavy J, Aslanger A, et al. Homozygous mutation in NUP107 leads to microcephaly with steroid-resistant nephrotic condition similar to Galloway-Mowat syndrome. J Med Genet. 2017;54:399-403 pubmed publisher
    ..we identified a shared homozygous variant leading to partial exon 4 skipping in nucleoporin, 107-KD (NUP107)...
  28. Park E, Ahn Y, Kang H, Miyake N, Tsukaguchi H, Cheong H. NUP107 mutations in children with steroid-resistant nephrotic syndrome. Nephrol Dial Transplant. 2017;32:1013-1017 pubmed publisher
    b>NUP107 is a novel gene associated with autosomal recessive steroid-resistant nephrotic syndrome (SRNS) with focal segmental glomerulosclerosis (FSGS) in children. The frequency of NUP107 mutations in children with SR-FSGS remains unknown...
  29. Mishra R, Chakraborty P, Arnaoutov A, Fontoura B, Dasso M. The Nup107-160 complex and gamma-TuRC regulate microtubule polymerization at kinetochores. Nat Cell Biol. 2010;12:164-9 pubmed publisher
    ..disassembles during mitosis, and many of its constituents distribute onto spindles and kinetochores, including the Nup107-160 sub-complex...
  30. Bui K, von Appen A, DiGuilio A, Ori A, Sparks L, Mackmull M, et al. Integrated structural analysis of the human nuclear pore complex scaffold. Cell. 2013;155:1233-43 pubmed publisher
    ..and crosslinking mass spectrometry to determine the structure of a major scaffold motif of the human NPC, the Nup107 subcomplex, in both isolation and integrated into the NPC...
  31. Miyake N, Tsukaguchi H, Koshimizu E, Shono A, Matsunaga S, Shiina M, et al. Biallelic Mutations in Nuclear Pore Complex Subunit NUP107 Cause Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome. Am J Hum Genet. 2015;97:555-66 pubmed publisher
    ..Nucleoporin 107 kDa (NUP107) is a component of the NPC central scaffold and is an essential protein in all eukaryotic cells...
  32. Bastos R, Ribas de Pouplana L, Enarson M, Bodoor K, Burke B. Nup84, a novel nucleoporin that is associated with CAN/Nup214 on the cytoplasmic face of the nuclear pore complex. J Cell Biol. 1997;137:989-1000 pubmed
    ..out under nondenaturing conditions, and using a variety of antibodies, reveal a novel nonglycosylated nucleoporin, Nup84, that is tightly associated with CAN/Nup214...
  33. Dowling J, Becker C, Bourke N, Corr S, Connolly D, Quinn S, et al. Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation. J Biol Chem. 2014;289:6429-37 pubmed publisher
    ..Collectively, our data indicate that PML limits ASC function, retaining ASC in the nucleus. ..
  34. Jagot Lacoussiere L, Faye A, Bruzzoni Giovanelli H, Villoutreix B, Rain J, Poyet J. DNA damage-induced nuclear translocation of Apaf-1 is mediated by nucleoporin Nup107. Cell Cycle. 2015;14:1242-51 pubmed publisher
    ..We demonstrated that Apaf-1 associates with the nucleoporin Nup107 and this association is necessary for Apaf-1 nuclear import...
  35. Boehmer T, Schwartz T. Purification, crystallization and preliminary X-ray analysis of a Nup107-Nup133 heterodimeric nucleoporin complex. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007;63:816-8 pubmed
    ..Nups are organized into distinct subcomplexes. Nup107 and Nup133 are members of the essential Nup107-160 subcomplex, a component of the central NPC architecture...
  36. Berke I, Boehmer T, Blobel G, Schwartz T. Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex. J Cell Biol. 2004;167:591-7 pubmed
    ..Nup133 contains two domains: a COOH-terminal domain responsible for its interaction with its subcomplex through Nup107; and an NH2-terminal domain whose crystal structure reveals a seven-bladed beta-propeller...
  37. Walther T, Askjaer P, Gentzel M, Habermann A, Griffiths G, Wilm M, et al. RanGTP mediates nuclear pore complex assembly. Nature. 2003;424:689-94 pubmed
    ..Here we demonstrate that RanGTP production is required to dissociate nucleoporins Nup107, Nup153 and Nup358 from Importin beta, to target them to chromatin and to induce association between separate NPC ..
  38. Banerjee H, Gibbs J, Jordan T, Blackshear M. Depletion of a single nucleoporin, Nup107, induces apoptosis in eukaryotic cells. Mol Cell Biochem. 2010;343:21-5 pubmed publisher
    ..The proteins that make up the NPC are known as nucleoporins. In mammalian cells, Nup107 is the homolog of yeast Nup84p nucleoporin...
  39. González Aguilera C, Askjaer P. Dissecting the NUP107 complex: multiple components and even more functions. Nucleus. 2012;3:340-8 pubmed
    ..One of these subcomplexes is the NUP107 complex, constituted by 7-9 members...
  40. Jabs V, Edlund K, König H, Grinberg M, Madjar K, Rahnenführer J, et al. Integrative analysis of genome-wide gene copy number changes and gene expression in non-small cell lung cancer. PLoS ONE. 2017;12:e0187246 pubmed publisher
    ..05). Among them are the chaperone CCT2, the core complex protein NUP107 and the ubiquitination and neddylation associated protein CAND1...
  41. Alanee S, Delfino K, Wilber A, Robinson K, Brard L, Semaan A. Single nucleotide variant in Nucleoporin 107 may be predictive of sensitivity to chemotherapy in patients with ovarian cancer. Pharmacogenet Genomics. 2017;27:264-269 pubmed publisher
    ..SNV rs79419059 (10T>C) in Nucleoporin 107 (Nup107) was associated with platinum resistance (P=0...
  42. Krull S, Thyberg J, Bjorkroth B, Rackwitz H, Cordes V. Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket. Mol Biol Cell. 2004;15:4261-77 pubmed
    ..of several human NPC proteins relative to the NPC core and its associated basket, including Nup93, Nup96, Nup98, Nup107, Nup153, Nup205, and the coiled coil-dominated 267-kDa protein Tpr...
  43. Kaur S, White T, DiGuilio A, Glavy J. The discovery of a Werner Helicase Interacting Protein (WHIP) association with the nuclear pore complex. Cell Cycle. 2010;9:3106-11 pubmed
    ..Through mass spectral analysis of the isolated Nuclear Pore Nup107-160 subcomplex, we discovered an in vivo interaction with Werner's Helicase Interacting Protein 1, (WRNIP1 or WHIP)..
  44. Tie H, Madugula V, Lu L. The development of a single molecule fluorescence standard and its application in estimating the stoichiometry of the nuclear pore complex. Biochem Biophys Res Commun. 2016;478:1694-9 pubmed publisher
    ..Our measured stoichiometry of Nup35, Nup93, Nup133 and Nup88 is 23, 18, 14 and 9 and there are possibly16 copies of Nup107-160 complex per nuclear pore complex.
  45. Hase M, Cordes V. Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex. Mol Biol Cell. 2003;14:1923-40 pubmed
    ..NPC assembly and recruitment of several nucleoporins, including Nup50, Nup93, Nup96, Nup98, Nup107, and Nup153, in anaphase/early telophase is shown to precede NPC association of Tpr in late telophase...
  46. Morchoisne Bolhy S, Geoffroy M, Bouhlel I, Alves A, Audugé N, Baudin X, et al. Intranuclear dynamics of the Nup107-160 complex. Mol Biol Cell. 2015;26:2343-56 pubmed publisher
    ..Here we show that the mammalian Nup107-160 complex (Y-complex), a major scaffold module of the nuclear pore, together with its partner Elys, colocalizes ..
  47. Platani M, Santarella Mellwig R, Posch M, Walczak R, Swedlow J, Mattaj I. The Nup107-160 nucleoporin complex promotes mitotic events via control of the localization state of the chromosome passenger complex. Mol Biol Cell. 2009;20:5260-75 pubmed publisher
    The human Nup107-160 nucleoporin complex plays a major role in formation of the nuclear pore complex and is localized to kinetochores in mitosis...
  48. Boehmer T, Jeudy S, Berke I, Schwartz T. Structural and functional studies of Nup107/Nup133 interaction and its implications for the architecture of the nuclear pore complex. Mol Cell. 2008;30:721-31 pubmed publisher
    ..assembly of the NPC, we have solved the crystal structure of a protein complex between two nucleoporins, human Nup107 and Nup133...
  49. Weinberg Shukron A, Renbaum P, Kalifa R, Zeligson S, Ben Neriah Z, Dreifuss A, et al. A mutation in the nucleoporin-107 gene causes XX gonadal dysgenesis. J Clin Invest. 2015;125:4295-304 pubmed publisher
    ..homozygosity mapping and whole-exome sequencing, we identified a recessive missense mutation in nucleoporin-107 (NUP107, c.1339G>A, p.D447N)...
  50. Whittle J, Schwartz T. Architectural nucleoporins Nup157/170 and Nup133 are structurally related and descend from a second ancestral element. J Biol Chem. 2009;284:28442-52 pubmed publisher
    ..We hypothesize that the extant NPC evolved early during eukaryotic evolution from a rudimentary structure composed of several identical copies of a few ancestral elements, later diversified and specified by gene duplication...
  51. Vasu S, Shah S, Orjalo A, Park M, Fischer W, Forbes D. Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. J Cell Biol. 2001;155:339-54 pubmed
    ..Purification and sequence analysis revealed that two are the known vertebrate nucleoporins, Nup96 and Nup107, whereas two mapped to ORFs of unknown function...
  52. Kim S, Kang H, Choi H, Park S. Reduction of Nup107 attenuates the growth factor signaling in the senescent cells. Biochem Biophys Res Commun. 2010;401:131-6 pubmed publisher
    ..In this study, we found markedly decreased level of Nup107, a key scaffold protein in nuclear pore complex assembly, in senescent human diploid fibroblasts as well as in ..
  53. Apelt L, Knockenhauer K, Leksa N, Benlasfer N, Schwartz T, Stelzl U. Systematic Protein-Protein Interaction Analysis Reveals Intersubcomplex Contacts in the Nuclear Pore Complex. Mol Cell Proteomics. 2016;15:2594-606 pubmed publisher
    ..Our data favors an assembly model in which major architectural elements of the NPC, notably the Y-complex, exist in different structural contexts within the scaffold. ..
  54. Teimer R, Kosinski J, von Appen A, Beck M, Hurt E. A short linear motif in scaffold Nup145C connects Y-complex with pre-assembled outer ring Nup82 complex. Nat Commun. 2017;8:1107 pubmed publisher
    ..Many of these Nups are organized into subcomplexes, of which the Y-shaped Nup84 complex is the major constituent of the nuclear and cytoplasmic rings...
  55. De Magistris P, Tatarek Nossol M, Dewor M, Antonin W. A self-inhibitory interaction within Nup155 and membrane binding are required for nuclear pore complex formation. J Cell Sci. 2018;131: pubmed publisher
    ..In vertebrates, the cytoplasmic and nucleoplasmic rings of NPCs are mostly formed by multiple copies of the Nup107-Nup160 complex, whereas the central, or inner ring is composed of Nup53, Nup93, Nup155 and the two paralogues ..
  56. Zhu Y, Wang B, Tang K, Hsu C, Xie S, Du H, et al. An Arabidopsis Nucleoporin NUP85 modulates plant responses to ABA and salt stress. PLoS Genet. 2017;13:e1007124 pubmed publisher
    ..spectrometry analysis revealed that NUP85 is potentially associated with HOS1 and other nucleoporins within the nup107-160 complex, along with several mediator subunits...
  57. Goeres J, Chan P, Mukhopadhyay D, Zhang H, Raught B, Matunis M. The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex. Mol Biol Cell. 2011;22:4868-82 pubmed publisher
    ..A second element mediates interactions with the Nup107-160 nucleoporin subcomplex. A third element consists of a nuclear export signal...
  58. Glavy J, Krutchinsky A, Cristea I, Berke I, Boehmer T, Blobel G, et al. Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex. Proc Natl Acad Sci U S A. 2007;104:3811-6 pubmed
    ..In this study, we examined the cell-cycle-dependent phosphorylation of the Nup107-160 subcomplex, a core building block of the NPC...