nucleolin

Summary

Gene Symbol: nucleolin
Description: nucleolin
Alias: C23, Nsr1, nucleolin
Species: human
Products:     nucleolin

Top Publications

  1. Callé A, Ugrinova I, Epstein A, Bouvet P, Diaz J, Greco A. Nucleolin is required for an efficient herpes simplex virus type 1 infection. J Virol. 2008;82:4762-73 pubmed publisher
    ..Here, we show that the three most abundant nucleolar proteins--nucleolin, B23, and fibrillarin--are redistributed out of the nucleoli as a consequence of HSV-1 infection...
  2. Shi H, Huang Y, Zhou H, Song X, Yuan S, Fu Y, et al. Nucleolin is a receptor that mediates antiangiogenic and antitumor activity of endostatin. Blood. 2007;110:2899-906 pubmed
    ..Here, we report that endostatin specifically binds to the cell surface nucleolin with high affinity...
  3. Galzio R, Rosati F, Benedetti E, Cristiano L, Aldi S, Mei S, et al. Glycosilated nucleolin as marker for human gliomas. J Cell Biochem. 2012;113:571-9 pubmed publisher
    b>Nucleolin is a multifunctional DNA and RNA binding protein involved in regulation of gene transcription, chromatin remodeling, RNA metabolism, and ribosomal RNA synthesis...
  4. Fu Y, Chen Y, Luo X, Liang Y, Shi H, Gao L, et al. The heparin binding motif of endostatin mediates its interaction with receptor nucleolin. Biochemistry. 2009;48:11655-63 pubmed publisher
    Endostatin is a potent angiogenesis inhibitor with heparin-dependent activities. Nucleolin, a novel functional receptor of endostatin, mediates both the internalization to endothelial cells and the antiangiogenic activity of endostatin...
  5. Tayyari F, Marchant D, Moraes T, Duan W, Mastrangelo P, Hegele R. Identification of nucleolin as a cellular receptor for human respiratory syncytial virus. Nat Med. 2011;17:1132-5 pubmed publisher
    ..Here we show that RSV interacts with host-cell nucleolin via the viral fusion envelope glycoprotein and binds specifically to nucleolin at the apical cell surface in ..
  6. Chen J, Guo K, Kastan M. Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA. J Biol Chem. 2012;287:16467-76 pubmed publisher
    ..B. (2005) Cell 123, 49-63; Chen, J., and Kastan, M. B. (2010) Genes Dev. 24, 2146-2156). In contrast, nucleolin (NCL) suppresses the translation of p53 mRNA and its induction after DNA damage...
  7. Yang X, Xu Z, Li D, Cheng S, Fan K, Li C, et al. Cell surface nucleolin is crucial in the activation of the CXCL12/CXCR4 signaling pathway. Tumour Biol. 2014;35:333-8 pubmed publisher
    ..At the same time, cell surface nucleolin is also over-expressed in PTC and others...
  8. Ridley L, Rahman R, Brundler M, Ellison D, Lowe J, Robson K, et al. Multifactorial analysis of predictors of outcome in pediatric intracranial ependymoma. Neuro Oncol. 2008;10:675-89 pubmed publisher
    ..microarray from 97 intracranial tumors from 74 patients (WHO grade II-III) and analyzed the candidate markers nucleolin, telomerase catalytic subunit (hTERT; antibody clone 44F12), survivin, Ki-67, and members of the receptor ..
  9. Takagi M, Absalon M, McLure K, Kastan M. Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell. 2005;123:49-63 pubmed
    ..Ribosomal protein L26 (RPL26) and nucleolin were found to bind to the 5' untranslated region (UTR) of p53 mRNA and to control p53 translation and induction ..

More Information

Publications79

  1. Saxena A, Rorie C, Dimitrova D, Daniely Y, Borowiec J. Nucleolin inhibits Hdm2 by multiple pathways leading to p53 stabilization. Oncogene. 2006;25:7274-88 pubmed
    b>Nucleolin is a c-Myc-induced gene product with defined roles in ribosomal RNA processing and the inhibition of chromosomal DNA replication following stress...
  2. Becherel O, Gueven N, Birrell G, Schreiber V, Suraweera A, Jakob B, et al. Nucleolar localization of aprataxin is dependent on interaction with nucleolin and on active ribosomal DNA transcription. Hum Mol Genet. 2006;15:2239-49 pubmed
    ..describe here, the interaction and interdependence between aprataxin and several nucleolar proteins, including nucleolin, nucleophosmin and upstream binding factor-1 (UBF-1), involved in ribosomal RNA (rRNA) synthesis and cellular ..
  3. Soundararajan S, Wang L, Sridharan V, Chen W, Courtenay Luck N, Jones D, et al. Plasma membrane nucleolin is a receptor for the anticancer aptamer AS1411 in MV4-11 leukemia cells. Mol Pharmacol. 2009;76:984-91 pubmed publisher
    ..AS1411 binds to nucleolin, a protein that is overexpressed in the cytoplasm and on the plasma membrane of some tumor cells compared with ..
  4. Grinstein E, Du Y, Santourlidis S, Christ J, Uhrberg M, Wernet P. Nucleolin regulates gene expression in CD34-positive hematopoietic cells. J Biol Chem. 2007;282:12439-49 pubmed
    ..b>Nucleolin is an abundant multifunctional phosphoprotein of growing eukaryotic cells, involved in regulation of gene ..
  5. Pichiorri F, Palmieri D, De Luca L, Consiglio J, You J, Rocci A, et al. In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation. J Exp Med. 2013;210:951-68 pubmed publisher
    ..Here we find that nucleolin (NCL), a major nucleolar protein, posttranscriptionally regulates the expression of a specific subset of miRNAs, ..
  6. Murayama R, Harada Y, Shibata T, Kuroda K, Hayakawa S, Shimizu K, et al. Influenza A virus non-structural protein 1 (NS1) interacts with cellular multifunctional protein nucleolin during infection. Biochem Biophys Res Commun. 2007;362:880-5 pubmed
    ..We identified nucleolin, a multifunctional major nucleolar protein, as a novel NS1-binding protein...
  7. Liu H, Yung B. In vivo interaction of nucleophosmin/B23 and protein C23 during cell cycle progression in HeLa cells. Cancer Lett. 1999;144:45-54 pubmed
    ..protein complex at molecular weight of about 140 kDa was recognized by both nucleophosmin/B23 and protein C23 MAbs. Both C23 and nucleophosmin/B23 could be detected from the cross-linked complex immunoprecipitated by C23 MAb...
  8. Fogal V, Sugahara K, Ruoslahti E, Christian S. Cell surface nucleolin antagonist causes endothelial cell apoptosis and normalization of tumor vasculature. Angiogenesis. 2009;12:91-100 pubmed publisher
    b>Nucleolin is specifically transported to the surface of proliferating endothelial cells in vitro and in vivo...
  9. Fouraux M, Bouvet P, Verkaart S, van Venrooij W, Pruijn G. Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes. J Mol Biol. 2002;320:475-88 pubmed
    ..Using this approach, we have identified the RNA-binding protein nucleolin as a novel subunit of Ro RNP particles containing hY1 or hY3 RNA, but not hY4 and hY5 RNA...
  10. Shiohama A, Sasaki T, Noda S, Minoshima S, Shimizu N. Nucleolar localization of DGCR8 and identification of eleven DGCR8-associated proteins. Exp Cell Res. 2007;313:4196-207 pubmed
    ..These proteins included Nucleolin, ILF3 and others, most of which appeared to be involved in the RNA processing or RNA transportation...
  11. Said E, Krust B, Nisole S, Svab J, Briand J, Hovanessian A. The anti-HIV cytokine midkine binds the cell surface-expressed nucleolin as a low affinity receptor. J Biol Chem. 2002;277:37492-502 pubmed
    ..a cytokine that inhibits the attachment of human immunodeficiency virus particles by a mechanism similar to the nucleolin binding HB-19 pseudopeptide...
  12. Johansson H, Svensson F, Runnberg R, Simonsson T, Simonsson S. Phosphorylated nucleolin interacts with translationally controlled tumor protein during mitosis and with Oct4 during interphase in ES cells. PLoS ONE. 2010;5:e13678 pubmed publisher
    ..Although Nucleolin (Ncl) is one of the most abundant nucleolar proteins, its interaction partners in ES cells have remained ..
  13. Farin K, Schokoroy S, Haklai R, Cohen Or I, Elad Sfadia G, Reyes Reyes M, et al. Oncogenic synergism between ErbB1, nucleolin, and mutant Ras. Cancer Res. 2011;71:2140-51 pubmed publisher
    ..Furthermore, it was observed that nucleolin, a transcriptional regulator and ribosome biogenesis factor, can bind both K-Ras and the cytoplasmic tail of ..
  14. Losfeld M, Khoury D, Mariot P, Carpentier M, Krust B, Briand J, et al. The cell surface expressed nucleolin is a glycoprotein that triggers calcium entry into mammalian cells. Exp Cell Res. 2009;315:357-69 pubmed publisher
    b>Nucleolin is an ubiquitous nucleolar phosphoprotein involved in fundamental aspects of transcription regulation, cell proliferation and growth...
  15. Gattoni Celli S, Buckner C, Lazarchick J, Stuart R, Fernandes D. Overexpression of nucleolin in engrafted acute myelogenous leukemia cells. Am J Hematol. 2009;84:535-8 pubmed publisher
  16. Bhatt P, d Avout C, Kane N, Borowiec J, Saxena A. Specific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53 ubiquitination. FEBS J. 2012;279:370-83 pubmed publisher
    b>Nucleolin is an abundant multifunctional nucleolar protein with defined roles in ribosomal RNA processing, RNA polymerase I catalyzed transcription and the regulation of apoptosis...
  17. Kobayashi J, Fujimoto H, Sato J, Hayashi I, Burma S, Matsuura S, et al. Nucleolin participates in DNA double-strand break-induced damage response through MDC1-dependent pathway. PLoS ONE. 2012;7:e49245 pubmed publisher
    ..As a result, we identified nucleolin as one of candidates. Here, we show a novel role of a major nucleolar protein, nucleolin, in DDR...
  18. Ishimaru D, Zuraw L, Ramalingam S, Sengupta T, Bandyopadhyay S, Reuben A, et al. Mechanism of regulation of bcl-2 mRNA by nucleolin and A+U-rich element-binding factor 1 (AUF1). J Biol Chem. 2010;285:27182-91 pubmed publisher
    ..b>Nucleolin is one of the proteins that binds to bcl-2 mRNA, thereby increasing its half-life...
  19. Grinstein E, Shan Y, Karawajew L, Snijders P, Meijer C, Royer H, et al. Cell cycle-controlled interaction of nucleolin with the retinoblastoma protein and cancerous cell transformation. J Biol Chem. 2006;281:22223-35 pubmed
    ..b>Nucleolin is an abundant multifunctional phosphoprotein of proliferating and cancerous cells, recently identified as cell ..
  20. Ma N, Matsunaga S, Takata H, Ono Maniwa R, Uchiyama S, Fukui K. Nucleolin functions in nucleolus formation and chromosome congression. J Cell Sci. 2007;120:2091-105 pubmed
    ..a combination of high-resolution microscopy and RNA-interference-mediated depletion to study the functions of nucleolin, a nucleolar protein localized at the chromosome periphery, in interphase and mitosis...
  21. Srivastava M, McBride O, Fleming P, Pollard H, Burns A. Genomic organization and chromosomal localization of the human nucleolin gene. J Biol Chem. 1990;265:14922-31 pubmed
    b>Nucleolin, a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes...
  22. Said E, Courty J, Svab J, Delbe J, Krust B, Hovanessian A. Pleiotrophin inhibits HIV infection by binding the cell surface-expressed nucleolin. FEBS J. 2005;272:4646-59 pubmed
    The growth factor pleiotrophin (PTN) has been reported to bind heparan sulfate and nucleolin, two components of the cell surface implicated in the attachment of HIV-1 particles to cells...
  23. Otake Y, Sengupta T, Bandyopadhyay S, Spicer E, Fernandes D. Retinoid-induced apoptosis in HL-60 cells is associated with nucleolin down-regulation and destabilization of Bcl-2 mRNA. Mol Pharmacol. 2005;67:319-26 pubmed
    ..Cellular differentiation was accompanied by down-regulation of the cytoplasmic levels of nucleolin, a bcl-2 mRNA-stabilizing protein...
  24. Squatrito M, Mancino M, Donzelli M, Areces L, Draetta G. EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes. Oncogene. 2004;23:4454-65 pubmed
    ..Our findings indicate that EBP1 is a nucleolar growth-regulating protein, and we propose that it could represent a new link between ribosome biosynthesis and cell proliferation. ..
  25. Huang Y, Shi H, Zhou H, Song X, Yuan S, Luo Y. The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin. Blood. 2006;107:3564-71 pubmed
    b>Nucleolin, originally described as a nuclear protein, was recently found to be expressed on the surface of endothelial cells during angiogenic. However, the functions of cell-surface nucleolin in angiogenic remain mysterious...
  26. Greco A, Arata L, Soler E, Gaume X, Cout Y, Hacot S, et al. Nucleolin interacts with US11 protein of herpes simplex virus 1 and is involved in its trafficking. J Virol. 2012;86:1449-57 pubmed publisher
    ..and clear nucleolar localization very similar to that of the major multifunctional nucleolar protein nucleolin. To determine whether US11 interacts with nucleolin, we purified US11 protein partners by coimmunoprecipitations ..
  27. Pickering B, Yu D, Van Dyke M. Nucleolin protein interacts with microprocessor complex to affect biogenesis of microRNAs 15a and 16. J Biol Chem. 2011;286:44095-103 pubmed publisher
    ..Here we show that nucleolin, another protein critical for rRNA processing, is involved in the biogenesis of microRNA 15a/16 (miR-15a/16), ..
  28. Tuteja R, Tuteja N. Nucleolin: a multifunctional major nucleolar phosphoprotein. Crit Rev Biochem Mol Biol. 1998;33:407-36 pubmed
    b>Nucleolin is a major protein of exponentially growing eukaryotic cells where it is present in abundance at the heart of the nucleolus. It is highly conserved during evolution...
  29. Krust B, El Khoury D, Nondier I, Soundaramourty C, Hovanessian A. Targeting surface nucleolin with multivalent HB-19 and related Nucant pseudopeptides results in distinct inhibitory mechanisms depending on the malignant tumor cell type. BMC Cancer. 2011;11:333 pubmed publisher
    b>Nucleolin expressed at the cell surface is a binding protein for a variety of ligands implicated in tumorigenesis and angiogenesis...
  30. Ceman S, Brown V, Warren S. Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex. Mol Cell Biol. 1999;19:7925-32 pubmed
    ..We identify two of these proteins as FXR1P and FXR2P by using specific antisera and identify a third protein as nucleolin by using mass spectrometry...
  31. Ying G, Proost P, Van Damme J, Bruschi M, Introna M, Golay J. Nucleolin, a novel partner for the Myb transcription factor family that regulates their activity. J Biol Chem. 2000;275:4152-8 pubmed
    ..We identify nucleolin as one of the nuclear polypeptides that interact specifically with the A-Myb and c-Myb, but not B-Myb DNA-..
  32. Strang B, Boulant S, Coen D. Nucleolin associates with the human cytomegalovirus DNA polymerase accessory subunit UL44 and is necessary for efficient viral replication. J Virol. 2010;84:1771-84 pubmed publisher
    ..Unexpectedly, nucleolin, a major protein component of the nucleolus, was identified among these proteins by mass spectrometry and ..
  33. Daniely Y, Dimitrova D, Borowiec J. Stress-dependent nucleolin mobilization mediated by p53-nucleolin complex formation. Mol Cell Biol. 2002;22:6014-22 pubmed
    We recently discovered that heat shock causes nucleolin to relocalize from the nucleolus to the nucleoplasm, whereupon it binds replication protein A and inhibits DNA replication initiation...
  34. Caudle W, Kitsou E, Li J, Bradner J, Zhang J. A role for a novel protein, nucleolin, in Parkinson's disease. Neurosci Lett. 2009;459:11-5 pubmed publisher
    ..Previously, in a cellular model of PD, we identified nucleolin as a protein interacting with alpha-synuclein and DJ-1, two critical proteins involved in PD pathogenesis...
  35. Yu Y, Maggi L, Brady S, Apicelli A, Dai M, Lu H, et al. Nucleophosmin is essential for ribosomal protein L5 nuclear export. Mol Cell Biol. 2006;26:3798-809 pubmed
    ..Inhibition of NPM shuttling or loss of NPM blocked the nuclear export of rpL5 and 5S rRNA, resulting in cell cycle arrest and demonstrating that NPM and its nuclear export provide a unique and necessary chaperoning activity to rpL5/5S. ..
  36. Sinclair J, O Brien A. Intimin types alpha, beta, and gamma bind to nucleolin with equivalent affinity but lower avidity than to the translocated intimin receptor. J Biol Chem. 2004;279:33751-8 pubmed publisher
    ..reported that gamma intimin of EHEC O157:H7 also bound to a eucaryotic receptor that we determined was nucleolin. The objective of this study was to investigate in vitro and in vivo the interactions of intimins alpha, beta, ..
  37. Angelov D, Bondarenko V, Almagro S, Menoni H, Mongelard F, Hans F, et al. Nucleolin is a histone chaperone with FACT-like activity and assists remodeling of nucleosomes. EMBO J. 2006;25:1669-79 pubmed
    ..Here we report that the nuclear protein nucleolin possesses a histone chaperone activity and that this factor greatly enhances the activity of the chromatin ..
  38. Ugrinova I, Monier K, Ivaldi C, Thiry M, Storck S, Mongelard F, et al. Inactivation of nucleolin leads to nucleolar disruption, cell cycle arrest and defects in centrosome duplication. BMC Mol Biol. 2007;8:66 pubmed
    b>Nucleolin is a major component of the nucleolus, but is also found in other cell compartments...
  39. Carpentier M, Morelle W, Coddeville B, Pons A, Masson M, Mazurier J, et al. Nucleolin undergoes partial N- and O-glycosylations in the extranuclear cell compartment. Biochemistry. 2005;44:5804-15 pubmed
    b>Nucleolin is an ubiquitous, nonhistone nucleolar phosphoprotein involved in fundamental aspects of transcription regulation, cell proliferation, and growth...
  40. Erard M, Belenguer P, Caizergues Ferrer M, Pantaloni A, Amalric F. A major nucleolar protein, nucleolin, induces chromatin decondensation by binding to histone H1. Eur J Biochem. 1988;175:525-30 pubmed
    ..to probe the extent of DNA condensation in chromatin, we have demonstrated that a major nucleolar protein, nucleolin can decondense chromatin...
  41. Larrucea S, González Rubio C, Cambronero R, Ballou B, Bonay P, Lopez Granados E, et al. Cellular adhesion mediated by factor J, a complement inhibitor. Evidence for nucleolin involvement. J Biol Chem. 1998;273:31718-25 pubmed
    ..of 110 kDa was isolated by affinity chromatography, and microsequence analysis identified this protein as nucleolin. Confocal microscopy evidenced the presence of nucleolin in cell membrane by immunofluorescence with monoclonal (..
  42. Tominaga K, Srikantan S, Lee E, Subaran S, Martindale J, Abdelmohsen K, et al. Competitive regulation of nucleolin expression by HuR and miR-494. Mol Cell Biol. 2011;31:4219-31 pubmed publisher
    The RNA-binding protein (RBP) nucleolin promotes the expression of several proliferative proteins. Nucleolin levels are high in cancer cells, but the mechanisms that control nucleolin expression are unknown...
  43. Fähling M, Steege A, Perlewitz A, Nafz B, Mrowka R, Persson P, et al. Role of nucleolin in posttranscriptional control of MMP-9 expression. Biochim Biophys Acta. 2005;1731:32-40 pubmed
    ..RNA/protein interaction studies indicate that the elevated binding of nucleolin ( approximately 64 kDa form) to the 3'UTR may be of major importance for the increased efficiency of MMP-9 ..
  44. Hirano K, Miki Y, Hirai Y, Sato R, Itoh T, Hayashi A, et al. A multifunctional shuttling protein nucleolin is a macrophage receptor for apoptotic cells. J Biol Chem. 2005;280:39284-93 pubmed
    ..Here we show that this receptor is nucleolin, a multifunctional shuttling protein present in nucleus, cytoplasm, and on the surface of some types of cells...
  45. Birchenall Roberts M, Fu T, Kim S, Huang Y, Dambach M, Resau J, et al. K-Ras4B proteins are expressed in the nucleolus: Interaction with nucleolin. Biochem Biophys Res Commun. 2006;348:540-9 pubmed
    ..b>Nucleolin, a pleiotropic regulator of cellular processes, including transcriptional regulation, is also characterized by a ..
  46. Peng L, Liang J, Wang H, Song X, Rashid A, Gomez H, et al. High levels of nucleolar expression of nucleolin are associated with better prognosis in patients with stage II pancreatic ductal adenocarcinoma. Clin Cancer Res. 2010;16:3734-42 pubmed publisher
    b>Nucleolin is a major nucleolar protein that has been shown to be overexpressed in rapidly dividing cells and plays an essential role in cell proliferation and survival...
  47. Abdelmohsen K, Gorospe M. RNA-binding protein nucleolin in disease. RNA Biol. 2012;9:799-808 pubmed publisher
    b>Nucleolin is a multifunctional protein localized primarily in the nucleolus, but also found in the nucleoplasm, cytoplasm and cell membrane...
  48. Das S, Cong R, Shandilya J, Senapati P, Moindrot B, Monier K, et al. Characterization of nucleolin K88 acetylation defines a new pool of nucleolin colocalizing with pre-mRNA splicing factors. FEBS Lett. 2013;587:417-24 pubmed publisher
    b>Nucleolin is a multifunctional protein that carries several post-translational modifications. We characterized nucleolin acetylation and developed antibodies specific to nucleolin K88 acetylation...
  49. Gonzalez V, Guo K, Hurley L, Sun D. Identification and characterization of nucleolin as a c-myc G-quadruplex-binding protein. J Biol Chem. 2009;284:23622-35 pubmed publisher
    ..We found that nucleolin, a multifunctional phosphoprotein, binds in vitro to the c-myc G-quadruplex structure with high affinity and ..
  50. Mi Y, Thomas S, Xu X, Casson L, Miller D, Bates P. Apoptosis in leukemia cells is accompanied by alterations in the levels and localization of nucleolin. J Biol Chem. 2003;278:8572-9 pubmed
    ..In this study, we have examined apoptosis-induced alterations in two proteins, nucleolin and poly(ADP-ribose) polymerase-1 (PARP-1), in U937 leukemia cells...
  51. Zhao H, Huang Y, Xue C, Chen Y, Hou X, Guo Y, et al. Prognostic significance of the combined score of endothelial expression of nucleolin and CD31 in surgically resected non-small cell lung cancer. PLoS ONE. 2013;8:e54674 pubmed publisher
    b>Nucleolin is implicated to play a role in angiogenesis, a vital process in tumor growth and metastasis. However, the presence and clinical relevance of nucleolin in human non small cell lung cancer (NSCLC) remains largely unknown...
  52. Christian S, Pilch J, Akerman M, Porkka K, Laakkonen P, Ruoslahti E. Nucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vessels. J Cell Biol. 2003;163:871-8 pubmed
    ..Here, we show that the cell surface molecule recognized by F3 is nucleolin. Nucleolin specifically bound to an F3 peptide affinity matrix from extracts of cultured breast carcinoma cells...
  53. Barel M, Hovanessian A, Meibom K, Briand J, Dupuis M, Charbit A. A novel receptor - ligand pathway for entry of Francisella tularensis in monocyte-like THP-1 cells: interaction between surface nucleolin and bacterial elongation factor Tu. BMC Microbiol. 2008;8:145 pubmed publisher
    ..tularensis internalization has been suggested. We show here that cell-surface expressed nucleolin is a receptor for Francisella tularensis Live Vaccine Strain (LVS) and promotes LVS binding and infection of ..
  54. Sengupta T, Bandyopadhyay S, Fernandes D, Spicer E. Identification of nucleolin as an AU-rich element binding protein involved in bcl-2 mRNA stabilization. J Biol Chem. 2004;279:10855-63 pubmed
    ..Matrix-assisted laser desorption ionization mass spectroscopy analysis identified these proteins as full-length nucleolin and proteolytic fragments of nucleolin...
  55. Turck N, Lefebvre O, Gross I, Gendry P, Kedinger M, Simon Assmann P, et al. Effect of laminin-1 on intestinal cell differentiation involves inhibition of nuclear nucleolin. J Cell Physiol. 2006;206:545-55 pubmed
    ..In this study, we investigated the possible role and the subcellular localization of nucleolin, a nuclear shuttling protein, in relation to differentiation of human intestinal epithelial Caco2/TC7 cells ..
  56. Hovanessian A, Soundaramourty C, El Khoury D, Nondier I, Svab J, Krust B. Surface expressed nucleolin is constantly induced in tumor cells to mediate calcium-dependent ligand internalization. PLoS ONE. 2010;5:e15787 pubmed publisher
    b>Nucleolin is one of the major proteins of the nucleolus, but it is also expressed on the cell surface where is serves as a binding protein for variety of ligands implicated in tumorigenesis and angiogenesis...
  57. Jordan P, Heid H, Kinzel V, Kübler D. Major cell surface-located protein substrates of an ecto-protein kinase are homologs of known nuclear proteins. Biochemistry. 1994;33:14696-706 pubmed
    ..in most cases showed significant consensus sequences between pp100 and the nuclear RNA-binding protein nucleolin while pp120 sequences proved to be related to hnRNP U, a nucleoplasmic pre-mRNA-binding protein...
  58. Li Y, Busch R, Valdez B, Busch H. C23 interacts with B23, a putative nucleolar-localization-signal-binding protein. Eur J Biochem. 1996;237:153-8 pubmed
    The human protein C23 (nucleolin) is a major nucleolar protein. Its interactions with other proteins were studied with the two-hybrid system which identified nucleolar protein B23 (nucleophosmin) as being associated with C23...
  59. Woo H, Baker T, László C, Chambers S. Nucleolin mediates microRNA-directed CSF-1 mRNA deadenylation but increases translation of CSF-1 mRNA. Mol Cell Proteomics. 2013;12:1661-77 pubmed publisher
    ..We find that nucleolin, which binds both G-quadruplex and AREs, enhances deadenylation of CSF-1 mRNA, promoting CSF-1 mRNA decay, while ..
  60. Srivastava M, Fleming P, Pollard H, Burns A. Cloning and sequencing of the human nucleolin cDNA. FEBS Lett. 1989;250:99-105 pubmed
    A cDNA containing the entire coding region for human nucleolin has been isolated from a lambda gt10 human retinal library using a bovine cDNA probe...
  61. Uribe D, Guo K, Shin Y, Sun D. Heterogeneous nuclear ribonucleoprotein K and nucleolin as transcriptional activators of the vascular endothelial growth factor promoter through interaction with secondary DNA structures. Biochemistry. 2011;50:3796-806 pubmed publisher
    ..G-rich) strands of this tract with transcription factors heterogeneous nuclear ribonucleoprotein (hnRNP) K and nucleolin, respectively, both in vitro and in vivo and their potential role in the transcriptional control of VEGF...
  62. Villacé P, Marion R, Ortin J. The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs. Nucleic Acids Res. 2004;32:2411-20 pubmed
    ..In addition, proteins normally found in the nucleus, like nucleolin and RNA helicase A, were also found associated with cytosolic hStaufen complexes...
  63. Rickards B, Flint S, Cole M, LeRoy G. Nucleolin is required for RNA polymerase I transcription in vivo. Mol Cell Biol. 2007;27:937-48 pubmed
    ..In this study, we purified and identified nucleolin as a protein that allows RNA polymerase II to transcribe nucleosomal templates in vitro...
  64. Schenck A, Bardoni B, Moro A, Bagni C, Mandel J. A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P. Proc Natl Acad Sci U S A. 2001;98:8844-9 pubmed
    ..Consistent with FMRP and Rac1 localization in dendritic fine structures, CYFIP1/2 are present in synaptosomal extracts. ..
  65. Nisole S, Krust B, Hovanessian A. Anchorage of HIV on permissive cells leads to coaggregation of viral particles with surface nucleolin at membrane raft microdomains. Exp Cell Res. 2002;276:155-73 pubmed
    The cross-linking of HIV on permissive cells results aggregation of HIV particles with surface nucleolin, CD4, and CXCR4, but without affecting the organization of CD45...
  66. Pasternack M, Bleier K, McInerney T. Granzyme A binding to target cell proteins. Granzyme A binds to and cleaves nucleolin in vitro. J Biol Chem. 1991;266:14703-8 pubmed
    ..reactive moieties, and the N-terminal sequence of the 100-kDa protein confirmed that this protein was murine nucleolin. Incubation of granzyme A with nucleolin generates a discrete proteolytic cleavage product of Mr = 88,000...
  67. Kim S, Srivastava M. Stability of Nucleolin protein as the basis for the differential expression of Nucleolin mRNA and protein during serum starvation. DNA Cell Biol. 2003;22:171-8 pubmed
    b>Nucleolin is a nucleolar phosphoprotein that plays a direct role in ribosome biogenesis. Our aim was to determine how its activity as a growth-promoting factor is coordinated with, if not regulated by, the cell cycle machinery...
  68. Reyes Reyes E, Akiyama S. Cell-surface nucleolin is a signal transducing P-selectin binding protein for human colon carcinoma cells. Exp Cell Res. 2008;314:2212-23 pubmed publisher
    ..Here, we identified by affinity chromatography and characterized nucleolin as a P-selectin receptor on Colo-320 cells...
  69. Yang L, Reece J, Cho J, Bortner C, Shears S. The nucleolus exhibits an osmotically regulated gatekeeping activity that controls the spatial dynamics and functions of nucleolin. J Biol Chem. 2008;283:11823-31 pubmed publisher
    ..regulate a gatekeeping function for the nucleolus that controls the spatial dynamics and functions of nucleolin. HeLa cells and U2-OS osteosarcoma cells were osmotically challenged with 100-200 mm sorbitol, and the ..
  70. Teng Y, Girvan A, Casson L, Pierce W, Qian M, Thomas S, et al. AS1411 alters the localization of a complex containing protein arginine methyltransferase 5 and nucleolin. Cancer Res. 2007;67:10491-500 pubmed
    AS1411 is a quadruplex-forming oligonucleotide aptamer that targets nucleolin. It is currently in clinical trials as a treatment for various cancers...