Genomes and Genes
Gene Symbol: NUCKS
Description: nuclear casein kinase and cyclin-dependent kinase substrate 1
Alias: NUCKS, nuclear ubiquitous casein and cyclin-dependent kinase substrate 1, nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate, potential LAG1 interactor
- Identification and characterization of two putative nuclear localization signals (NLS) in the DNA-binding protein NUCKSKirsten Grundt
Department of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, P O Box 1112, Blindern, 0317 Oslo, Norway
Biochim Biophys Acta 1773:1398-406. 2007Immunofluorescence analyses show that the vertebrate specific and DNA-binding protein NUCKS is distributed throughout the cytoplasm in mitotic cells and targeted to the reforming nuclei in late telophase of the cell cycle...
- Constitutive and dynamic phosphorylation and acetylation sites on NUCKS, a hypermodified nuclear protein, studied by quantitative proteomicsJacek R Wisniewski
Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Martinsried, Germany
Proteins 73:710-8. 2008Nuclear ubiquitous casein and cyclin-dependent kinases substrate (NUCKS) is a 27 kDa chromosomal protein of unknown function...
- Molecular cloning of a mammalian nuclear phosphoprotein NUCKS, which serves as a substrate for Cdk1 in vivoA C Ostvold
Department of Medical Biochemistry, University of Oslo, Norway
Eur J Biochem 268:2430-40. 2001We have isolated and characterized a cDNA encoding a mammalian nuclear phosphoprotein NUCKS, previously designated P1...
- Identification and confirmation of a module of coexpressed genesH Garrett R Thompson
Department of Biomedical Engineering, University of California Irvine, Irvine, California 92697, USA
Genome Res 12:1517-22. 2002..contains at least six members that are believed to be involved in either transcritional regulation (PDEF, H2AFO, NUCKS) or the ubiquitin proteasome pathway (PSMD7, SQSTM1, FLJ10111)...
- A putative DNA-binding domain in the NUCKS proteinKirsten Grundt
Department of Medical Biochemistry, University of Oslo, Box 1115 Blindern, Oslo, Norway
Arch Biochem Biophys 407:168-75. 2002We have studied the DNA-binding properties of a NUCKS-derived, synthetic peptide containing an extended GRP motif. This peptide binds to random-sequence DNA, but did not bind preferentially to poly(dA-dT)...
- Characterisation of the NUCKS gene on human chromosome 1q32.1 and the presence of a homologous gene in different speciesKirsten Grundt
Department of Medical Biochemistry, Institute Group of Basic Medical Sciences, University of Oslo, Norway
Biochem Biophys Res Commun 323:796-801. 2004The NUCKS gene is located on human chromosome 1q32.1 and consists of seven exons and six introns. The gene lacks a TATA box but contains two Inr elements, two GC boxes, and one consensus-binding site for E2F-1...
- Immunocytochemical studies on the nuclear ubiquitous casein and cyclin-dependent kinases substrate following 5-aminolevulinicacid-mediated photodynamic therapy on MCF-7 cellsKatarzyna Hotowy
Department of Clinical Biochemistry, Wroclaw Medical University, 50 367 Wrocław, Poland
Photodiagnosis Photodyn Ther 10:518-25. 2013Recent data indicates that nuclear ubiquitous casein and cyclin-dependent kinases substrate (NUCKS) may play role in tumor growth...
- Identification of NUCKS1 as a colorectal cancer prognostic marker through integrated expression and copy number analysisAkifumi Kikuchi
Department of Surgical Oncology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
Int J Cancer 132:2295-302. 2013..The overexpression of NUCKS1 in cancer cells could be used as a CRC prognostic marker and might also be a target for treatment of this disease...
- Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese populationJielin Sun
Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
Hum Genet 132:423-9. 2013..Identification of these genetic markers provides new insight into the molecular mechanisms of PSA. Taking individual variation into account, these genetic variants may improve the performance of PSA to predict prostate cancer...
- [Cyst of Nucks canal associated with recurrent inguinal hernia]Denzil Garteiz Martínez
Hospital Angeles Lomas, Huixquilucan, Estado de Mexico
Ginecol Obstet Mex 81:52-6. 2013..We report the case of a woman with a cyst of Nuck that presented as a recurrent inguinal hernia. Discussion is centered on the embryologic, anatomic, clinical and therapeutic aspects of this condition...
- MiR-125b, miR-100 and miR-99a co-regulate vincristine resistance in childhood acute lymphoblastic leukemiaF Akbari Moqadam
Department of Pediatric Oncology and Hematology, Erasmus MC Sophia Children s Hospital, University Medical Centre Rotterdam, Rotterdam, The Netherlands
Leuk Res 37:1315-21. 2013..05). The concerted function of miR-125b in combination with miR-99a and/or miR-100 illustrates the complexity of vincristine-resistant pediatric ALL...
- Inflammation and neurological disease-related genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalitiesJonathan Savitz
Laureate Institute for Brain Research, Tulsa, OK 74136, USA
Brain Behav Immun 31:161-71. 2013..Our results raise the possibility that molecular-level immune dysfunction can be mapped onto macro-level neuroimaging abnormalities, potentially elucidating a mechanism by which inflammation leads to depression...
- Identification of nine novel loci associated with white blood cell subtypes in a Japanese populationYukinori Okada
Laboratory for Statistical Analysis, Center for Genomic Medicine, Institute of Physical and Chemical Research, Yokohama, Japan
PLoS Genet 7:e1002067. 2011..This study should contribute to the understanding of the genetic backgrounds of the WBC subtypes and hematological traits...
- Genetic variability at the PARK16 locusArianna Tucci
Department of Molecular Neuroscience and Reta Lila Weston Institute, UCL Institute of Neurology, London, UK
Eur J Hum Genet 18:1356-9. 2010....
- Immunohistochemical and proteomic evaluation of nuclear ubiquitous casein and cyclin-dependent kinases substrate in invasive ductal carcinoma of the breastPiotr Ziółkowski
Department of Pathology, Wrocław Medical University, 1 Marcinkowskiego Street, 50 368 Wroclaw, Poland
J Biomed Biotechnol 2009:919645. 2009Nuclear ubiquitous casein and cyclin-dependent kinases substrate (NUCKS) is 27 kDa chromosomal protein of unknown function...
- Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's diseaseWataru Satake
Division of Neurology Molecular Brain Science, Kobe University Graduate School of Medicine, Kobe, Japan
Nat Genet 41:1303-7. 2009..Our results identify two new PD susceptibility loci, show involvement of autosomal dominant parkinsonism loci in typical PD and suggest that population differences contribute to genetic heterogeneity in PD...
- Genome-wide association study reveals genetic risk underlying Parkinson's diseaseJavier Simon-Sanchez
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
Nat Genet 41:1308-12. 2009..14, P = 1.55 x 10(-5)). These data demonstrate an unequivocal role for common genetic variants in the etiology of typical PD and suggest population-specific genetic heterogeneity in this disease...
- Chromosomal changes in high- and low-invasive mouse lung adenocarcinoma cell strains derived from early passage mouse lung adenocarcinoma cell strainsLinda M Sargent
National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Toxicol Appl Pharmacol 233:81-91. 2008..analysis and confirmation by real time PCR demonstrated increased expression of COX-2, Translin (TB-RBP), DYRK3, NUCKS and Tubulin-alpha4 genes in the high-invasive cell strains...
- Cell adhesion molecule SC1/DMGRASP is expressed on growing axons of retina ganglion cells and is involved in mediating their extension on axonsG E Pollerberg
Max Planck Institute for Developmental Biology, Department of Biochemistry, Tubingen, Germany
Dev Biol 165:670-87. 1994....
- Role of H11 kinase in cardiac cell growthChristophe Depre; Fiscal Year: 2007..Putative interactions include the nuclear casein kinase II (NUCKS II), a stimulator of cell growth, the protein HSP27, a stimulator of cell survival, and the nucleosome assembly ..
- Determining the role of RAD51AP1: a new gene in DNA repair and genomic stabilityDavid Schild; Fiscal Year: 2009..regions of RAD51AP1 are important for its RAD51- interaction and its role in HRR, including regions conserved with NUCKS (Nuclear, Kinase Substrate), a RAD51AP1 paralog (Aims 3 & 4); and 5) to test if the functions of NUCKS and ..
- Determining the role of RAD51AP1: a new gene in DNA repair and genomic stabilityDavid Schild; Fiscal Year: 2010..regions of RAD51AP1 are important for its RAD51- interaction and its role in HRR, including regions conserved with NUCKS (Nuclear, Kinase Substrate), a RAD51AP1 paralog (Aims 3 &4);and 5) to test if the functions of NUCKS and ..