NUCKS

Summary

Gene Symbol: NUCKS
Description: nuclear casein kinase and cyclin-dependent kinase substrate 1
Alias: NUCKS, nuclear ubiquitous casein and cyclin-dependent kinase substrate 1, nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate, potential LAG1 interactor
Species: human

Top Publications

  1. ncbi Identification and characterization of two putative nuclear localization signals (NLS) in the DNA-binding protein NUCKS
    Kirsten Grundt
    Department of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, P O Box 1112, Blindern, 0317 Oslo, Norway
    Biochim Biophys Acta 1773:1398-406. 2007
  2. doi Constitutive and dynamic phosphorylation and acetylation sites on NUCKS, a hypermodified nuclear protein, studied by quantitative proteomics
    Jacek R Wisniewski
    Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Martinsried, Germany
    Proteins 73:710-8. 2008
  3. ncbi Molecular cloning of a mammalian nuclear phosphoprotein NUCKS, which serves as a substrate for Cdk1 in vivo
    A C Ostvold
    Department of Medical Biochemistry, University of Oslo, Norway
    Eur J Biochem 268:2430-40. 2001
  4. pmc Identification and confirmation of a module of coexpressed genes
    H Garrett R Thompson
    Department of Biomedical Engineering, University of California Irvine, Irvine, California 92697, USA
    Genome Res 12:1517-22. 2002
  5. ncbi A putative DNA-binding domain in the NUCKS protein
    Kirsten Grundt
    Department of Medical Biochemistry, University of Oslo, Box 1115 Blindern, Oslo, Norway
    Arch Biochem Biophys 407:168-75. 2002
  6. ncbi Characterisation of the NUCKS gene on human chromosome 1q32.1 and the presence of a homologous gene in different species
    Kirsten Grundt
    Department of Medical Biochemistry, Institute Group of Basic Medical Sciences, University of Oslo, Norway
    Biochem Biophys Res Commun 323:796-801. 2004
  7. doi Immunocytochemical studies on the nuclear ubiquitous casein and cyclin-dependent kinases substrate following 5-aminolevulinicacid-mediated photodynamic therapy on MCF-7 cells
    Katarzyna Hotowy
    Department of Clinical Biochemistry, Wroclaw Medical University, 50 367 Wrocław, Poland
    Photodiagnosis Photodyn Ther 10:518-25. 2013
  8. doi Identification of NUCKS1 as a colorectal cancer prognostic marker through integrated expression and copy number analysis
    Akifumi Kikuchi
    Department of Surgical Oncology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Int J Cancer 132:2295-302. 2013
  9. doi Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population
    Jielin Sun
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Hum Genet 132:423-9. 2013
  10. ncbi [Cyst of Nucks canal associated with recurrent inguinal hernia]
    Denzil Garteiz Martínez
    Hospital Angeles Lomas, Huixquilucan, Estado de Mexico
    Ginecol Obstet Mex 81:52-6. 2013

Scientific Experts

  • Denzil Garteiz Martínez
  • Jonathan B Savitz
  • Kirsten Grundt
  • Linda M Sargent
  • Jacek R Wisniewski
  • Yukinori Okada
  • Christophe Depre
  • David Schild
  • Claudia Wiese
  • Piotr Ziółkowski
  • Jielin Sun
  • F Akbari Moqadam
  • Katarzyna Hotowy
  • Akifumi Kikuchi
  • Beata Osiecka
  • Arianna Tucci
  • Andrew B Singleton
  • Coro Paisan-Ruiz
  • Henry Houlden
  • Wataru Satake
  • Javier Simon-Sanchez
  • H Garrett R Thompson
  • Elzbieta Czapińska
  • Junjie Feng
  • Hiroshi Tanaka
  • Ju Zhang
  • Xiaobo Yang
  • Xiaoling Lin
  • M L den Boer
  • Sha Tao
  • Yanling Hu
  • Jianfeng Xu
  • Zengnan Mo
  • Ming Liu
  • Grzegorz Terlecki
  • Seong Tae Kim
  • Aihua Tan
  • Qian Liu
  • I M Ariës
  • Kamila Duś
  • Linjian Mo
  • Kenichi Sugihara
  • Kaoru Mogushi
  • S Lilly Zheng
  • Li Li
  • Andrzej Gamian
  • Xianghua Huang
  • R Pieters
  • Hiroshi Mizushima
  • Marta Wozniak
  • Yong Gao
  • Megumi Ishiguro
  • Shijun Zhang
  • E A M Lange-Turenhout
  • Deyi Shi
  • Tao Peng
  • Andrzej Bronowicz
  • Xue Qin
  • Yongming Wu
  • Toshiaki Ishikawa
  • Hiroyuki Uetake
  • Satoru Iida
  • Zhixian Li
  • Haiying Zhang
  • Zhang Huang
  • Zhengjia Liang
  • Małgorzata Krzystek-Korpacka
  • A C Ostvold
  • Mike A Nalls
  • Nicholas W Wood
  • Tamas Revesz
  • John Hardy
  • Tatsushi Toda
  • Fumiya Obata
  • John A Hardy
  • Bryan J Traynor
  • Michael Steffens
  • Alison Goate
  • Xuemei Huang
  • Honglei Chen
  • Michael A Nalls
  • Nick W Wood
  • Masahiko Watanabe
  • Sampath Arepalli
  • Hiroyuki Tomiyama
  • Daniela Berg
  • Yuko Nakabayashi
  • Stephen J Chanock
  • Thomas Illig
  • Michiaki Kubo

Detail Information

Publications20

  1. ncbi Identification and characterization of two putative nuclear localization signals (NLS) in the DNA-binding protein NUCKS
    Kirsten Grundt
    Department of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, P O Box 1112, Blindern, 0317 Oslo, Norway
    Biochim Biophys Acta 1773:1398-406. 2007
    Immunofluorescence analyses show that the vertebrate specific and DNA-binding protein NUCKS is distributed throughout the cytoplasm in mitotic cells and targeted to the reforming nuclei in late telophase of the cell cycle...
  2. doi Constitutive and dynamic phosphorylation and acetylation sites on NUCKS, a hypermodified nuclear protein, studied by quantitative proteomics
    Jacek R Wisniewski
    Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Martinsried, Germany
    Proteins 73:710-8. 2008
    Nuclear ubiquitous casein and cyclin-dependent kinases substrate (NUCKS) is a 27 kDa chromosomal protein of unknown function...
  3. ncbi Molecular cloning of a mammalian nuclear phosphoprotein NUCKS, which serves as a substrate for Cdk1 in vivo
    A C Ostvold
    Department of Medical Biochemistry, University of Oslo, Norway
    Eur J Biochem 268:2430-40. 2001
    We have isolated and characterized a cDNA encoding a mammalian nuclear phosphoprotein NUCKS, previously designated P1...
  4. pmc Identification and confirmation of a module of coexpressed genes
    H Garrett R Thompson
    Department of Biomedical Engineering, University of California Irvine, Irvine, California 92697, USA
    Genome Res 12:1517-22. 2002
    ..contains at least six members that are believed to be involved in either transcritional regulation (PDEF, H2AFO, NUCKS) or the ubiquitin proteasome pathway (PSMD7, SQSTM1, FLJ10111)...
  5. ncbi A putative DNA-binding domain in the NUCKS protein
    Kirsten Grundt
    Department of Medical Biochemistry, University of Oslo, Box 1115 Blindern, Oslo, Norway
    Arch Biochem Biophys 407:168-75. 2002
    We have studied the DNA-binding properties of a NUCKS-derived, synthetic peptide containing an extended GRP motif. This peptide binds to random-sequence DNA, but did not bind preferentially to poly(dA-dT)...
  6. ncbi Characterisation of the NUCKS gene on human chromosome 1q32.1 and the presence of a homologous gene in different species
    Kirsten Grundt
    Department of Medical Biochemistry, Institute Group of Basic Medical Sciences, University of Oslo, Norway
    Biochem Biophys Res Commun 323:796-801. 2004
    The NUCKS gene is located on human chromosome 1q32.1 and consists of seven exons and six introns. The gene lacks a TATA box but contains two Inr elements, two GC boxes, and one consensus-binding site for E2F-1...
  7. doi Immunocytochemical studies on the nuclear ubiquitous casein and cyclin-dependent kinases substrate following 5-aminolevulinicacid-mediated photodynamic therapy on MCF-7 cells
    Katarzyna Hotowy
    Department of Clinical Biochemistry, Wroclaw Medical University, 50 367 Wrocław, Poland
    Photodiagnosis Photodyn Ther 10:518-25. 2013
    Recent data indicates that nuclear ubiquitous casein and cyclin-dependent kinases substrate (NUCKS) may play role in tumor growth...
  8. doi Identification of NUCKS1 as a colorectal cancer prognostic marker through integrated expression and copy number analysis
    Akifumi Kikuchi
    Department of Surgical Oncology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Int J Cancer 132:2295-302. 2013
    ..The overexpression of NUCKS1 in cancer cells could be used as a CRC prognostic marker and might also be a target for treatment of this disease...
  9. doi Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population
    Jielin Sun
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Hum Genet 132:423-9. 2013
    ..Identification of these genetic markers provides new insight into the molecular mechanisms of PSA. Taking individual variation into account, these genetic variants may improve the performance of PSA to predict prostate cancer...
  10. ncbi [Cyst of Nucks canal associated with recurrent inguinal hernia]
    Denzil Garteiz Martínez
    Hospital Angeles Lomas, Huixquilucan, Estado de Mexico
    Ginecol Obstet Mex 81:52-6. 2013
    ..We report the case of a woman with a cyst of Nuck that presented as a recurrent inguinal hernia. Discussion is centered on the embryologic, anatomic, clinical and therapeutic aspects of this condition...
  11. doi MiR-125b, miR-100 and miR-99a co-regulate vincristine resistance in childhood acute lymphoblastic leukemia
    F Akbari Moqadam
    Department of Pediatric Oncology and Hematology, Erasmus MC Sophia Children s Hospital, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Leuk Res 37:1315-21. 2013
    ..05). The concerted function of miR-125b in combination with miR-99a and/or miR-100 illustrates the complexity of vincristine-resistant pediatric ALL...
  12. pmc Inflammation and neurological disease-related genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalities
    Jonathan Savitz
    Laureate Institute for Brain Research, Tulsa, OK 74136, USA
    Brain Behav Immun 31:161-71. 2013
    ..Our results raise the possibility that molecular-level immune dysfunction can be mapped onto macro-level neuroimaging abnormalities, potentially elucidating a mechanism by which inflammation leads to depression...
  13. pmc Identification of nine novel loci associated with white blood cell subtypes in a Japanese population
    Yukinori Okada
    Laboratory for Statistical Analysis, Center for Genomic Medicine, Institute of Physical and Chemical Research, Yokohama, Japan
    PLoS Genet 7:e1002067. 2011
    ..This study should contribute to the understanding of the genetic backgrounds of the WBC subtypes and hematological traits...
  14. pmc Genetic variability at the PARK16 locus
    Arianna Tucci
    Department of Molecular Neuroscience and Reta Lila Weston Institute, UCL Institute of Neurology, London, UK
    Eur J Hum Genet 18:1356-9. 2010
    ....
  15. pmc Immunohistochemical and proteomic evaluation of nuclear ubiquitous casein and cyclin-dependent kinases substrate in invasive ductal carcinoma of the breast
    Piotr Ziółkowski
    Department of Pathology, Wrocław Medical University, 1 Marcinkowskiego Street, 50 368 Wroclaw, Poland
    J Biomed Biotechnol 2009:919645. 2009
    Nuclear ubiquitous casein and cyclin-dependent kinases substrate (NUCKS) is 27 kDa chromosomal protein of unknown function...
  16. doi Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
    Wataru Satake
    Division of Neurology Molecular Brain Science, Kobe University Graduate School of Medicine, Kobe, Japan
    Nat Genet 41:1303-7. 2009
    ..Our results identify two new PD susceptibility loci, show involvement of autosomal dominant parkinsonism loci in typical PD and suggest that population differences contribute to genetic heterogeneity in PD...
  17. pmc Genome-wide association study reveals genetic risk underlying Parkinson's disease
    Javier Simon-Sanchez
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 41:1308-12. 2009
    ..14, P = 1.55 x 10(-5)). These data demonstrate an unequivocal role for common genetic variants in the etiology of typical PD and suggest population-specific genetic heterogeneity in this disease...
  18. doi Chromosomal changes in high- and low-invasive mouse lung adenocarcinoma cell strains derived from early passage mouse lung adenocarcinoma cell strains
    Linda M Sargent
    National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 233:81-91. 2008
    ..analysis and confirmation by real time PCR demonstrated increased expression of COX-2, Translin (TB-RBP), DYRK3, NUCKS and Tubulin-alpha4 genes in the high-invasive cell strains...
  19. ncbi Cell adhesion molecule SC1/DMGRASP is expressed on growing axons of retina ganglion cells and is involved in mediating their extension on axons
    G E Pollerberg
    Max Planck Institute for Developmental Biology, Department of Biochemistry, Tubingen, Germany
    Dev Biol 165:670-87. 1994
    ....

Research Grants7

  1. Role of H11 kinase in cardiac cell growth
    Christophe Depre; Fiscal Year: 2007
    ..Putative interactions include the nuclear casein kinase II (NUCKS II), a stimulator of cell growth, the protein HSP27, a stimulator of cell survival, and the nucleosome assembly ..
  2. Determining the role of RAD51AP1: a new gene in DNA repair and genomic stability
    David Schild; Fiscal Year: 2009
    ..regions of RAD51AP1 are important for its RAD51- interaction and its role in HRR, including regions conserved with NUCKS (Nuclear, Kinase Substrate), a RAD51AP1 paralog (Aims 3 & 4); and 5) to test if the functions of NUCKS and ..
  3. Determining the role of RAD51AP1: a new gene in DNA repair and genomic stability
    David Schild; Fiscal Year: 2010
    ..regions of RAD51AP1 are important for its RAD51- interaction and its role in HRR, including regions conserved with NUCKS (Nuclear, Kinase Substrate), a RAD51AP1 paralog (Aims 3 &4);and 5) to test if the functions of NUCKS and ..