NTRK3

Summary

Gene Symbol: NTRK3
Description: neurotrophic receptor tyrosine kinase 3
Alias: GP145-TrkC, TRKC, gp145(trkC), NT-3 growth factor receptor, ETS related protein-neurotrophic receptor tyrosine kinase fusion protein, ETV6-NTRK3 fusion, neurotrophic tyrosine kinase, receptor, type 3, tyrosine kinase receptor C
Species: human
Products:     NTRK3

Top Publications

  1. Knezevich S, McFadden D, Tao W, Lim J, Sorensen P. A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. Nat Genet. 1998;18:184-7 pubmed
    ..breakpoints, we show that the rearrangement fuses the ETV6 (also known as TEL) gene from 12p13 with the 15q25 NTRK3 neurotrophin-3 receptor gene (also known as TRKC)...
  2. Wood L, Calhoun E, Silliman N, Ptak J, Szabo S, Powell S, et al. Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers. Hum Mutat. 2006;27:1060-1 pubmed
    ..We identified somatic mutations in GUCY2F, EPHA3, and NTRK3 in breast, lung, and pancreatic cancers...
  3. Bouzas Rodriguez J, Cabrera J, Delloye Bourgeois C, Ichim G, Delcros J, Raquin M, et al. Neurotrophin-3 production promotes human neuroblastoma cell survival by inhibiting TrkC-induced apoptosis. J Clin Invest. 2010;120:850-8 pubmed publisher
    Tropomyosin-related kinase receptor C (TrkC) is a neurotrophin receptor with tyrosine kinase activity that was expected to be oncogenic...
  4. Jin W, Kim G, Kim M, Lim M, Yun C, Jeong J, et al. TrkC plays an essential role in breast tumor growth and metastasis. Carcinogenesis. 2010;31:1939-47 pubmed publisher
    ..Here, we report that TrkC is frequently overexpressed in human breast cancers and plays an essential role in tumor growth and metastasis...
  5. Jin W, Lee J, Kim M, Son B, Cho Y, Kim H. DNA methylation-dependent regulation of TrkA, TrkB, and TrkC genes in human hepatocellular carcinoma. Biochem Biophys Res Commun. 2011;406:89-95 pubmed publisher
    The tropomyosin-related kinase (Trk) family of neurotrophin receptors, TrkA, TrkB and TrkC, has been implicated in the growth and survival of human cancers...
  6. Ichaso N, Rodriguez R, Martin Zanca D, Gonzalez Sarmiento R. Genomic characterization of the human trkC gene. Oncogene. 1998;17:1871-5 pubmed
    The trkC gene encodes the high-affinity receptor for neurotrophin 3 and plays an important role in the regulation of the survival and differentiation of the mammalian nervous system and in heart development...
  7. Hisaoka M, Sheng W, Tanaka A, Hashimoto H. Gene expression of TrkC (NTRK3) in human soft tissue tumours. J Pathol. 2002;197:661-7 pubmed
    ..except for a small fraction of tumours including congenital/infantile fibrosarcoma characterized by an ETV6-NTRK3 (also known as Tel-TrkC) fusion gene...
  8. Tognon C, Knezevich S, Huntsman D, Roskelley C, Melnyk N, Mathers J, et al. Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. Cancer Cell. 2002;2:367-76 pubmed
    ..that human secretory breast carcinoma (SBC), a rare subtype of infiltrating ductal carcinoma, expresses the ETV6-NTRK3 gene fusion previously cloned in pediatric mesenchymal cancers...
  9. Robinson K, Manto K, Buchsbaum R, MacDonald J, Meakin S. Neurotrophin-dependent tyrosine phosphorylation of Ras guanine-releasing factor 1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA. J Biol Chem. 2005;280:225-35 pubmed
    ..These studies identify RasGrf1 as a novel target of neurotrophin activation and suggest an additional pathway whereby neurotrophin-stimulated neurite outgrowth may be regulated. ..

More Information

Publications122 found, 100 shown here

  1. Otnaess M, Djurovic S, Rimol L, Kulle B, Kähler A, Jonsson E, et al. Evidence for a possible association of neurotrophin receptor (NTRK-3) gene polymorphisms with hippocampal function and schizophrenia. Neurobiol Dis. 2009;34:518-24 pubmed publisher
    ..The present results, although not robust, suggest that the NTRK-3 gene influences hippocampal function and may modify the risk for schizophrenia. ..
  2. Zeng X, Qiu X, Ma Y, Duan J, Chen Y, Gu H, et al. Integration of donor mesenchymal stem cell-derived neuron-like cells into host neural network after rat spinal cord transection. Biomaterials. 2015;53:184-201 pubmed publisher
    ..Rat bone marrow-derived mesenchymal stem cells (MSCs), genetically engineered to overexpress TrkC, receptor of neurotrophin-3 (NT-3), were pre-differentiated into cells carrying neuronal features via co-culture ..
  3. Abe M, Inaki R, Kanno Y, Hoshi K, Takato T. Molecular analysis of a mammary analog secretory carcinoma in the upper lip: Novel search for genetic and epigenetic abnormalities in MASC. Int J Surg Case Rep. 2015;9:8-11 pubmed publisher
    ..of the salivary glands characterized by an ETS variant 6 (ETV6)-neurotrophic tyrosine kinase receptor type 3 (NTRK3) fusion gene (EN fusion gene). We present a case of MASC derived from the left upper lip in a 61-year-old woman...
  4. Auer T, Xiao T, Bercier V, Gebhardt C, Duroure K, Concordet J, et al. Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3. elife. 2015;4: pubmed publisher
    ..This in turn promotes exuberant branching of retinal axons by signaling through the TrkC receptor (Ntrk3)...
  5. Nelson K, Peiris M, Meyer A, Siari A, Donoghue D. Receptor Tyrosine Kinases: Translocation Partners in Hematopoietic Disorders. Trends Mol Med. 2017;23:59-79 pubmed publisher
    ..Growth Factor Receptor (PDGFR), REarranged during Transfection (RET), Colony Stimulating Factor 1 Receptor (CSF1R), and Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) fusions, and discuss current therapeutic options.
  6. Vaishnavi A, Le A, Doebele R. TRKing down an old oncogene in a new era of targeted therapy. Cancer Discov. 2015;5:25-34 pubmed publisher
    ..alterations, most commonly gene fusions, have now been detected for the genes encoding the TRKA, TRKB, and TRKC receptor tyrosine kinases across multiple tumor types...
  7. Ekman M, Zhu B, Swärd K, Uvelius B. Neurite outgrowth in cultured mouse pelvic ganglia - Effects of neurotrophins and bladder tissue. Auton Neurosci. 2017;205:41-49 pubmed publisher
    ..The neurotrophin receptors TrkA, TrkB and TrkC were all expressed in neurons of the ganglia...
  8. Yang M, Pan Z, Huang K, Büsche G, Feuerhake F, Chaturvedi A, et al. Activation of TRKA receptor elicits mastocytosis in mice and is involved in the development of resistance to KIT-targeted therapy. Oncotarget. 2017;8:73871-73883 pubmed publisher
    ..The TRK (tropomyosin-related kinase) tyrosine kinase receptors (TRKA, TRKB, TRKC) are high affinity receptors for NTs...
  9. Thellman N, Botting C, Madaj Z, Triezenberg S. An Immortalized Human Dorsal Root Ganglion Cell Line Provides a Novel Context To Study Herpes Simplex Virus 1 Latency and Reactivation. J Virol. 2017;91: pubmed publisher
    ..neuronal morphology and express sensory neuron-associated markers such as neurotrophin receptors TrkA, TrkB, TrkC, and RET and the sensory neurofilament peripherin. Infection of mature HD10...
  10. Friedrich R, Holstein A, Middendorff R, Davidoff M. Vascular wall cells contribute to tumourigenesis in cutaneous neurofibromas of patients with neurofibromatosis type 1. A comparative histological, ultrastructural and immunohistochemical study. Anticancer Res. 2012;32:2139-58 pubmed
    ..neurotrophin receptor protein p75(NTR), high-affinity receptor protein TrkB (TrkB), high-affinity receptor protein TrkC (TrkC), the neurotrophin 3 (NT-3), and the brain-derived neurotrophic factor (BDNF)...
  11. Su Y, Chim S, Zhou L, Hassanshahi M, Chung R, Fan C, et al. Osteoblast derived-neurotrophin‑3 induces cartilage removal proteases and osteoclast-mediated function at injured growth plate in rats. Bone. 2018;116:232-247 pubmed publisher
    ..Moreover, NT-3 and receptor TrkC were induced during osteoclastogenesis, and rhNT-3 treatment activated TrkC downstream kinase Erk1/2 in ..
  12. Bucci C, Alifano P, Cogli L. The role of rab proteins in neuronal cells and in the trafficking of neurotrophin receptors. Membranes (Basel). 2014;4:642-77 pubmed publisher
    ..exert their role by binding to their receptors, the Trk family of receptor tyrosine kinases (TrkA, TrkB, and TrkC) and p75NTR, a member of the tumor necrosis factor (TNF) receptor superfamily...
  13. Guo Y, Su Z, Chen Y, Chai Z. Brain-derived neurotrophic factor/neurotrophin 3 regulate axon initial segment location and affect neuronal excitability in cultured hippocampal neurons. J Neurochem. 2017;142:260-271 pubmed publisher
    ..Furthermore, knockdown of neurotrophin receptors TrkB and TrkC caused distal movement of the AIS...
  14. Tiernan C, Ginsberg S, He B, Ward S, Guillozet Bongaarts A, Kanaan N, et al. Pretangle pathology within cholinergic nucleus basalis neurons coincides with neurotrophic and neurotransmitter receptor gene dysregulation during the progression of Alzheimer's disease. Neurobiol Dis. 2018;117:125-136 pubmed publisher
    ..Quantitative analysis revealed significant downregulation of mRNAs encoding TrkA as well as TrkB, TrkC, and the Trk-mediated downstream pro-survival kinase Akt in pS422+ compared to unlabeled, pS422-negative nbM ..
  15. Meldolesi J. Neurotrophin Trk Receptors: New Targets for Cancer Therapy. Rev Physiol Biochem Pharmacol. 2018;174:67-79 pubmed publisher
    ..TrkA, TrkB, and TrkC, activated by distinct neurotrophins, are high affinity stimulatory receptors...
  16. Huang L, Xian Q, Shen N, Shi L, Qu Y, Zhou L. Congenital absence of corticospinal tract does not severely affect plastic changes of the developing postnatal spinal cord. Neuroscience. 2015;301:338-50 pubmed publisher
    ..In contrast, expression profiles of brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase (Trk) B, TrkC, p75 neurotrophin receptor (p75(NTR)) and glial cell-line-derived neurotrophic factor (GDNF) were similar in both ..
  17. Qiao X, Yin F, Ji Y, Li Y, Yan P, Lai J. 5-Aza-2'-deoxycytidine in the medial prefrontal cortex regulates alcohol-related behavior and Ntf3-TrkC expression in rats. PLoS ONE. 2017;12:e0179469 pubmed publisher
    ..the alcohol-induced downregulation of neurotrophin-3 (Ntf3), correspondingly the expression of its receptor-TrkC was reduced...
  18. Bernal Sierra Y, Haseleu J, Kozlenkov A, Begay V, Lewin G. Genetic Tracing of Cav3.2 T-Type Calcium Channel Expression in the Peripheral Nervous System. Front Mol Neurosci. 2017;10:70 pubmed publisher
    ..5 showed that EGFP+ cells are a heterogeneous population consisting mainly of TrkB+ and TrkC+ cells, while only a small percentage of DRG cells were TrkA+...
  19. Vaughan S, Stanley O, Valdez G. Impact of Aging on Proprioceptive Sensory Neurons and Intrafusal Muscle Fibers in Mice. J Gerontol A Biol Sci Med Sci. 2017;72:771-779 pubmed publisher
    ..Our analysis also revealed normal levels of neurotrophin 3 (NT3) but dysregulated expression of the tyrosine kinase receptor C (TrkC) in aged muscles and DRGs, respectively...
  20. Tsunoda D, Iizuka H, Ichinose T, Iizuka Y, Mieda T, Shimokawa N, et al. The Trk family of neurotrophin receptors is downregulated in the lumbar spines of rats with congenital kyphoscoliosis. Mol Cell Biochem. 2016;412:11-8 pubmed publisher
    ..flexion sites of the IS rats showed low expression levels of tropomyosin receptor kinases (Trks: TrkA, TrkB, and TrkC), which belong to the neurotrophic receptor tyrosine kinase family...
  21. Johnson Chacko L, Blumer M, Pechriggl E, Rask Andersen H, Dietl W, Haim A, et al. Role of BDNF and neurotrophic receptors in human inner ear development. Cell Tissue Res. 2017;370:347-363 pubmed publisher
    ..TrkB and TrkC expression intensified towards GW 12, at which point the BDNF mRNA localization was at its lowest...
  22. Galkowska H, Olszewski W, Wojewodzka U, Rosinski G, Karnafel W. Neurogenic factors in the impaired healing of diabetic foot ulcers. J Surg Res. 2006;134:252-8 pubmed
    ..03). Expression of trkA and trkC receptors did not differ significantly between groups...
  23. Yasui M, Menjyo Y, Tokizane K, Shiozawa A, Tsuda M, Inoue K, et al. Hyperactivation of proprioceptors induces microglia-mediated long-lasting pain in a rat model of chronic fatigue syndrome. J Neuroinflammation. 2019;16:67 pubmed publisher
    ..More than 50% of ATF3-positive neurons simultaneously expressed the proprioceptor markers TrkC or VGluT1, whereas the co-expression rates for TrkA, TrkB, IB4, and CGRP were lower than 20%...
  24. Li L, Li Y, Jiang H. Neurotrophine-3 may contribute to neuronal differentiation of mesenchymal stem cells through the activation of the bone morphogenetic protein pathway. Cell Mol Biol Lett. 2015;20:385-403 pubmed publisher
    ..The pIRES2-EGFP-NT-3-transfected MSCs further underwent noggin treatment or siRNA-mediated knockout of the TrkC gene or were left untreated...
  25. Appelbaum T, Becker D, Santana E, Aguirre G. Molecular studies of phenotype variation in canine RPGR-XLPRA1. Mol Vis. 2016;22:319-31 pubmed
    ..RLBP1, RPGRORF15, RAB8A, RPGRIP1L, CEP290, CC2D2A, DFNB31, RAB11B, CRX, RCVRN, PVALB, CALB1, FGFR1, NTRK2, and NTRK3) involved in neuronal function...
  26. Tao Y, Piao S, Jin Y, Jin J, Zheng H, Zhao H, et al. Expression of brain-derived neurotrophic factor in kidneys from normal and cyclosporine-treated rats. BMC Nephrol. 2018;19:63 pubmed publisher
    ..death, oxidative stress (8-hydroxy-2'-deoxyguanosine, 8-OHdG), and expression of BDNF and Trk receptors (TrkB and TrkC) were compared between groups...
  27. Yalvac M, Amornvit J, Chen L, Shontz K, Lewis S, Sahenk Z. AAV1.NT-3 gene therapy increases muscle fiber diameter through activation of mTOR pathway and metabolic remodeling in a CMT mouse model. Gene Ther. 2018;25:129-138 pubmed publisher
    ..In vitro studies showed that recombinant NT-3 can directly induce Akt/mTOR pathway activation in the TrkC expressing myotubes but not in myoblasts...
  28. Shaqura M, Li X, Al Madol M, Tafelski S, Beyer Koczorek A, Mousa S, et al. Acute mechanical sensitization of peripheral nociceptors by aldosterone through non-genomic activation of membrane bound mineralocorticoid receptors in naive rats. Neuropharmacology. 2016;107:251-261 pubmed publisher
    ..and trkA-immunoreactive (IR) nociceptive neurons and only marginally with myelinated trkB-IR mechanoreceptive and trkC-IR proprioreceptive neurons underscoring a pivotal role for MR in the modulation of pain...
  29. Gruber Olipitz M, Strobel T, Kang S, John J, Grotzer M, Slavc I, et al. Neurotrophin 3/TrkC-regulated proteins in the human medulloblastoma cell line DAOY. Electrophoresis. 2009;30:540-9 pubmed publisher
    Medulloblastoma (MB) is the most common malignant childhood brain tumor and high neurotrophin (NP) receptor TrkC mRNA expression was identified as a powerful independent predictor of favorable survival outcome...
  30. Vigueras Villaseñor R, Cortés Trujillo L, Chávez Saldaña M, Vázquez F, Carrasco Daza D, Cuevas Alpuche O, et al. Analysis of POU5F1, c-Kit, PLAP, AP2γ and SALL4 in gonocytes of patients with cryptorchidism. Acta Histochem. 2015;117:752-61 pubmed publisher
    ..with pluripotent abilities expressing proteins like POU domain class 5 transcription factor 1 (POU5F1), tyrosine kinase receptor c-Kit, placental-like alkaline phosphatase (PLAP), the transcription factor AP2γ and sal-like protein 4 ..
  31. Chung J, Kim M, Im W, Hwang I, Bang M, Kim M. Expression of Neurotrophin-3 and trkC following Focal Cerebral Ischemia in Adult Rat Brain with Treadmill Exercise. Biomed Res Int. 2017;2017:9248542 pubmed publisher
    Neurotrophin-3 (NT-3) is a neurotrophic factor that mainly binds to the tyrosine kinase C (trkC) receptor. NT-3 has been shown to have neuroprotective effects in focal cerebral ischemia...
  32. Meakin S, MacDonald J, Gryz E, Kubu C, Verdi J. The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation. J Biol Chem. 1999;274:9861-70 pubmed
    ..Importantly, overexpression of FRS-2 in cells expressing an NGF nonresponsive TrkA receptor mutant reconstitutes the ability of NGF to stop cell cycle progression and to stimulate neuronal differentiation. ..
  33. Ferreira R, dos Santos N, Martins N, Fernandes L, dos Santos A. Caffeic Acid Phenethyl Ester (CAPE) Protects PC12 Cells from Cisplatin-Induced Neurotoxicity by Activating the NGF-Signaling Pathway. Neurotox Res. 2018;34:32-46 pubmed publisher
    ..The involvement of other neurotrophin receptors such as trkB and trkC is unlikely...
  34. Puehringer D, Orel N, Lüningschrör P, Subramanian N, Herrmann T, Chao M, et al. EGF transactivation of Trk receptors regulates the migration of newborn cortical neurons. Nat Neurosci. 2013;16:407-15 pubmed publisher
    ..We found that TrkB and TrkC, the receptors for brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), are activated by epidermal ..
  35. Xu Y, Cheng X, Cui X, Wang T, Liu G, Yang R, et al. Effects of 5-h multimodal stress on the molecules and pathways involved in dendritic morphology and cognitive function. Neurobiol Learn Mem. 2015;123:225-38 pubmed publisher
    ..damaged dendritic morphologies, and altered APBB1, CLSTN1, KCNA4, NOTCH3, PLAU, RPS6KA1, SYP, TGFB1, KCNA1, NTRK3, and SNCA expression in the brains of mice...
  36. Cordioli M, Moraes L, Bastos A, Besson P, Alves M, Delcelo R, et al. Fusion Oncogenes Are the Main Genetic Events Found in Sporadic Papillary Thyroid Carcinomas from Children. Thyroid. 2017;27:182-188 pubmed publisher
    ..Thirty-five pediatric PTCs were screened for the most prevalent fusions (RET/PTC1, RET/PTC2, RET/PTC3, ETV6-NTRK3, and AGK-BRAF) and point mutations (BRAFV600E and NRASQ61) described in sporadic pediatric ..
  37. Alonso P, Gratacos M, Menchon J, Segalas C, Gonzalez J, Labad J, et al. Genetic susceptibility to obsessive-compulsive hoarding: the contribution of neurotrophic tyrosine kinase receptor type 3 gene. Genes Brain Behav. 2008;7:778-85 pubmed publisher
    ..linkage disequilibrium (LD)-mapping approach to investigate whether neurotrophic tyrosine kinase receptor type 3 (NTRK3), the high-affinity receptor of neurotrophin 3 (NT-3), plays a role in increasing susceptibility to hoarding in ..
  38. Quattlebaum S, Roby B, Dishop M, Said M, CHAN K. A pediatric case of mammary analogue secretory carcinoma within the parotid. Am J Otolaryngol. 2015;36:741-3 pubmed publisher
    ..It is notable for a characteristic t(12;15)(p13;q25) translocation that results in a unique fusion protein, ETV6-NTRK3. While several studies have retrospectively identified this translocation in cases previously diagnosed as a ..
  39. Weinkauf C, Salvador R, PereiraPerrin M. Neurotrophin receptor TrkC is an entry receptor for Trypanosoma cruzi in neural, glial, and epithelial cells. Infect Immun. 2011;79:4081-7 pubmed publisher
    ..Earlier work in our laboratory showed that the neurotrophin-3 (NT-3) receptor TrkC is activated by T. cruzi surface trans-sialidase, also known as parasite-derived neurotrophic factor (PDNF)...
  40. Wu G, Diaz A, Paugh B, Rankin S, Ju B, Li Y, et al. The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat Genet. 2014;46:444-450 pubmed publisher
    ..in 47% of DIPGs and NBS-HGGs, with recurrent fusions involving the neurotrophin receptor genes NTRK1, NTRK2 and NTRK3 in 40% of NBS-HGGs in infants...
  41. Seethala R, Stenman G. Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Tumors of the Salivary Gland. Head Neck Pathol. 2017;11:55-67 pubmed publisher
    ..mainly from acinic cell carcinoma based on recapitulation of breast secretory carcinoma and a shared ETV6-NTRK3 gene fusion...
  42. Phung B, Sun J, Schepsky A, Steingrimsson E, Rönnstrand L. C-KIT signaling depends on microphthalmia-associated transcription factor for effects on cell proliferation. PLoS ONE. 2011;6:e24064 pubmed publisher
    The development of melanocytes is regulated by the tyrosine kinase receptor c-KIT and the basic-helix-loop-helix-leucine zipper transcription factor Mitf...
  43. Kamiya A, Inokuchi M, Otsuki S, Sugita H, Kato K, Uetake H, et al. Prognostic value of tropomyosin-related kinases A, B, and C in gastric cancer. Clin Transl Oncol. 2016;18:599-607 pubmed publisher
    ..We investigated correlations of the expression of TrkA, TrkB, and TrkC with clinicopathological features and outcomes in gastric cancer...
  44. Del Castillo M, Chibon F, Arnould L, Croce S, Ribeiro A, Perot G, et al. Secretory Breast Carcinoma: A Histopathologic and Genomic Spectrum Characterized by a Joint Specific ETV6-NTRK3 Gene Fusion. Am J Surg Pathol. 2015;39:1458-67 pubmed publisher
    ..to ETV6 on 12p13, reverse transcription polymerase chain reaction with in-house probes specific to the ETV6-NTRK3 gene fusion, and DNA copy number variation by array comparative genomic hybridization analyses were performed on ..
  45. Ribases M, Hervas A, Ramos Quiroga J, Bosch R, Bielsa A, Gastaminza X, et al. Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder. Biol Psychiatry. 2008;63:935-45 pubmed publisher
    ..NGF, BDNF, NTF3, and NTF4/5), a member of the cytokine family of NTFs (CNTF), and their receptors (NTRK1, NTRK2, NTRK3, NGFR, and CNTFR)...
  46. Ivanov S, Panaccione A, Brown B, Guo Y, Moskaluk C, Wick M, et al. TrkC signaling is activated in adenoid cystic carcinoma and requires NT-3 to stimulate invasive behavior. Oncogene. 2013;32:3698-710 pubmed publisher
    ..on clinical specimens of salivary cancers, we identified in ACC expression of the neurotrophin-3 receptor TrkC/NTRK3, neural crest marker SOX10, and other neurologic genes...
  47. Oczko Wojciechowska M, Swierniak M, Krajewska J, Kowalska M, Kowal M, Stokowy T, et al. Differences in the transcriptome of medullary thyroid cancer regarding the status and type of RET gene mutations. Sci Rep. 2017;7:42074 pubmed publisher
    ..of three genes: NNAT (suggested to be a tumour suppressor gene), CDC14B (involved in cell cycle control) and NTRK3 (tyrosine receptor kinase that undergoes rearrangement in papillary thyroid cancer)...
  48. Marler K, Becker Barroso E, MARTINEZ A, Llovera M, Wentzel C, Poopalasundaram S, et al. A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis. J Neurosci. 2008;28:12700-12 pubmed publisher
    ..In addition, our data suggest that growth factors and the EphA-ephrinA system interact in a way that affects axon branching and synapse development. ..
  49. Furuya N, Momose T, Katsuno K, Fushimi N, Muranaka H, Handa C, et al. The juxtamembrane region of TrkA kinase is critical for inhibitor selectivity. Bioorg Med Chem Lett. 2017;27:1233-1236 pubmed publisher
    ..pocket created by a novel JM configuration yields significant potency and high selectivity against TrkB and TrkC. Moreover, we validated the importance of the JM region for the potency of A1 using in vitro assays...
  50. Radin D, Patel P. BDNF: An Oncogene or Tumor Suppressor?. Anticancer Res. 2017;37:3983-3990 pubmed
    ..effects on cells are governed by the expression and activation of the tyrosine kinase receptors TrkA, TrkB and TrkC. TrkB has been immensely implicated in mediating neuronal migration, development and differentiation...
  51. Hui L, Tong S, Kaitu u Lino T, Hannan N. A comparison of sample collection methods for quantifying cell-free fetal neurodevelopment transcripts in amniotic fluid. BMC Res Notes. 2016;9:335 pubmed publisher
    ..RT qPCR was performed for the reference gene GAPDH, and three genes associated with neurodevelopment (NRXN3, NTRK3, and ZBTB18)...
  52. Shi E, Chmielecki J, Tang C, Wang K, Heinrich M, Kang G, et al. FGFR1 and NTRK3 actionable alterations in "Wild-Type" gastrointestinal stromal tumors. J Transl Med. 2016;14:339 pubmed
    ..Two tumors harbored FGFR1 gene fusions (FGFR1-HOOK3, FGFR1-TACC1) and one harbored an ETV6-NTRK3 fusion that responded to TRK inhibition...
  53. Weinkauf C, PereiraPerrin M. Trypanosoma cruzi promotes neuronal and glial cell survival through the neurotrophic receptor TrkC. Infect Immun. 2009;77:1368-75 pubmed publisher
    ..We show here that T. cruzi binds TrkC, a neurotrophic receptor expressed by glial cells and many types of neurons, and that the binding is specifically ..
  54. Dokanehiifard S, Soltani B, Parsi S, Hosseini F, Javan M, Mowla S. Experimental verification of a conserved intronic microRNA located in the human TrkC gene with a cell type-dependent apoptotic function. Cell Mol Life Sci. 2015;72:2613-25 pubmed publisher
    Tropomyosin receptor kinase C (TrkC) is involved in cell survival, apoptosis induction and tumorigenesis...
  55. Hechtman J, Zehir A, Yaeger R, Wang L, Middha S, Zheng T, et al. Identification of Targetable Kinase Alterations in Patients with Colorectal Carcinoma That are Preferentially Associated with Wild-Type RAS/RAF. Mol Cancer Res. 2016;14:296-301 pubmed publisher
    ..Three RTK fusions were identified: NCOA4-RET, ERBB2-GRB7, and ETV6-NTRK3. Only 1 of 6 patients with an RTK or MAP2K1 alteration who received anti-EGFR and/or anti-ERBB2 therapy ..
  56. Owusu B, Galemmo R, Janetka J, Klampfer L. Hepatocyte Growth Factor, a Key Tumor-Promoting Factor in the Tumor Microenvironment. Cancers (Basel). 2017;9: pubmed publisher
    ..constituent of the tumor stroma and Hepatocyte Growth Factor (HGF), the specific ligand for the tyrosine kinase receptor c-MET, is a major component of their secretome...
  57. Vanden Borre P, Schrock A, Anderson P, Morris J, Heilmann A, Holmes O, et al. Pediatric, Adolescent, and Young Adult Thyroid Carcinoma Harbors Frequent and Diverse Targetable Genomic Alterations, Including Kinase Fusions. Oncologist. 2017;22:255-263 pubmed publisher
    ..19/41) of PAYA PTC cases and in 1 of 3 AYA ATC cases, oncogenic fusions involving RET, NTRK1, NTRK3, and ALK were detected in 37% (15/41) of PAYA PTC and 33% (1/3) of AYA ATC cases...
  58. Zhang X, Ni H, Wang X, Chen H, Shi S, Yu B, et al. [Clinicopathologic features of mammary analogue secretory carcinoma of salivary glands]. Zhonghua Bing Li Xue Za Zhi. 2017;46:34-37 pubmed publisher
    ..2014 were included in this retrospective study, combined with immunohistochemistry and molecular detection of ETV6-NTRK3 gene fusion...
  59. Chumak T, Rüttiger L, Lee S, Campanelli D, Zuccotti A, Singer W, et al. BDNF in Lower Brain Parts Modifies Auditory Fiber Activity to Gain Fidelity but Increases the Risk for Generation of Central Noise After Injury. Mol Neurobiol. 2016;53:5607-27 pubmed publisher
    ..we used mice with a conditional deletion of BDNF in which Cre expression was under the control of the Pax2 or TrkC promoter...
  60. Saleh A, Soltani B, Dokanehiifard S, Medlej A, Tavalaei M, Mowla S. Experimental verification of a predicted novel microRNA located in human PIK3CA gene with a potential oncogenic function in colorectal cancer. Tumour Biol. 2016;37:14089-14101 pubmed
    ..Following the overexpression of PIK3CA-miR1, its predicted target genes (APPL1 and TrkC) were significantly downregulated in the CRC-originated HCT116 and SW480 cell lines, detected by qRT-PCR...
  61. Mallei A, Rabin S, Mocchetti I. Autocrine regulation of nerve growth factor expression by Trk receptors. J Neurochem. 2004;90:1085-93 pubmed
    ..the role of Trk in regulating the synthesis of neurotrophins, we exposed NIH-3T3 cells expressing TrkA or TrkC receptors to their cognate ligands as well as to GM1, a ganglioside that activates TrkA and TrkC by inducing the ..
  62. Lai B, Che M, Du B, Zeng X, Ma Y, Feng B, et al. Transplantation of tissue engineering neural network and formation of neuronal relay into the transected rat spinal cord. Biomaterials. 2016;109:40-54 pubmed publisher
    ..study tested our hypothesis if co-culture of neurotrophin-3 (NT-3) gene-modified Schwann cells (SCs, NT-3-SCs) and TrkC (NT-3 receptor) gene-modified neural stem cells (NSCs, TrkC-NSCs) in a gelatin sponge scaffold could construct a ..
  63. Eberhart C, Kratz J, Wang Y, Summers K, Stearns D, Cohen K, et al. Histopathological and molecular prognostic markers in medulloblastoma: c-myc, N-myc, TrkC, and anaplasia. J Neuropathol Exp Neurol. 2004;63:441-9 pubmed
    ..In contrast, high TrkC mRNA expression generally presages longer survival...
  64. Sánchez Mejías A, Fernandez R, Lopez Alonso M, Antinolo G, Borrego S. Contribution of RET, NTRK3 and EDN3 to the expression of Hirschsprung disease in a multiplex family. J Med Genet. 2009;46:862-4 pubmed publisher
    ..A multiplex HSCR family with an additive model of inheritance, in which the contribution of three genes (RET, NTRK3, EDN3) leads to the HSCR phenotype is reported...
  65. Milman T, Hu D, McCormick S, Eagle R, Crawford J, Chin K, et al. Expression of neurotrophin receptors by retinoinvasive uveal melanoma. Melanoma Res. 2012;22:164-8 pubmed publisher
    ..This study failed to demonstrate a direct causation between the expression of neurotrophin receptors and a retinoinvasive uveal melanoma growth pattern. ..
  66. Conner A, Kissling C, Hodges E, Hünnerkopf R, Clement R, Dudley E, et al. Neurotrophic factor-related gene polymorphisms and adult attention deficit hyperactivity disorder (ADHD) score in a high-risk male population. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1476-80 pubmed publisher
    ..The genes included NTF3, NTRK2 (TrkB), NTRK3 (TrkC), BDNF, and p75(NTR)...
  67. Kim J, Jeong J, Rhee J, Cho H, Chun J, Kim T, et al. Targeted exome sequencing for the identification of a protective variant against Internet gaming disorder at rs2229910 of neurotrophic tyrosine kinase receptor, type 3 (NTRK3): A pilot study. J Behav Addict. 2016;5:631-638 pubmed publisher
    ..Results rs2229910 of neurotrophic tyrosine kinase receptor, type 3 (NTRK3) was the only single nucleotide polymorphism (SNP) that exhibited a significantly different minor allele frequency ..
  68. Won S, Kim C, Kim D, Ko J, Um J, Lee S, et al. LAR-RPTP Clustering Is Modulated by Competitive Binding between Synaptic Adhesion Partners and Heparan Sulfate. Front Mol Neurosci. 2017;10:327 pubmed publisher
    ..1 (IL1RAPL1), interleukin-1 receptor accessory protein (IL-1RAcP) and neurotrophin receptor tyrosine kinase C (TrkC), to regulate synaptogenesis...
  69. Chen S, Nagel S, Schneider B, Dai H, Geffers R, Kaufmann M, et al. A new ETV6-NTRK3 cell line model reveals MALAT1 as a novel therapeutic target - a short report. Cell Oncol (Dordr). 2018;41:93-101 pubmed publisher
    ..This translocation leads to ETV6-NTRK3 (EN) gene fusions resulting in ectopic expression of the NTRK3 neurotropic tyrosine receptor kinase moiety as well ..
  70. Kim J, Sutton M, Lu D, Cho T, Goumnerova L, Goritchenko L, et al. Activation of neurotrophin-3 receptor TrkC induces apoptosis in medulloblastomas. Cancer Res. 1999;59:711-9 pubmed
    Elevated expression of the neurotrophin-3 (NT-3) receptor TrkC by childhood medulloblastomas is associated with favorable clinical outcome. Here, we provide evidence that TrkC is more than simply a passive marker of prognosis...
  71. Marchetti A, Felicioni L, Pelosi G, Del Grammastro M, Fumagalli C, Sciarrotta M, et al. Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung. Hum Mutat. 2008;29:609-16 pubmed publisher
    ..conformation polymorphism (SSCP) and sequencing of the tyrosine kinase domain (TKD) of NTRK1, NTRK2, and NTRK3. The NTRK1 gene was never found to be mutated...
  72. Mahmood H, Fatima H, Faheem M. Mammary Analogue Secretory Carcinoma of Parotid Gland in a Teenage Boy. J Coll Physicians Surg Pak. 2017;27:579-581 pubmed publisher
    ..gland malignancy that exhibits resemblance with secretory carcinoma of the breast (SC) due to the presence of ETV6-NTRK3 gene fusion, formerly classified as acinic cell carcinoma...
  73. Guiton M, Gunn Moore F, Glass D, Geis D, Yancopoulos G, Tavare J. Naturally occurring tyrosine kinase inserts block high affinity binding of phospholipase C gamma and Shc to TrkC and neurotrophin-3 signaling. J Biol Chem. 1995;270:20384-90 pubmed
    Neurotrophin-3 binds to the receptor tyrosine kinase, TrkC. Several naturally occurring splice variants of TrkC exist including those with 14- and 39-amino acid inserts within the tyrosine kinase homology region...
  74. Brodeur G, Minturn J, Ho R, Simpson A, Iyer R, Varela C, et al. Trk receptor expression and inhibition in neuroblastomas. Clin Cancer Res. 2009;15:3244-50 pubmed publisher
    ..Finally we address the progress that has been made in developing targeted therapy with Trk-selective inhibitors to treat neuroblastomas and other tumors with activated Trk expression. ..
  75. Amato R, Pinelli M, Monticelli A, Miele G, Cocozza S. Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation. BMC Evol Biol. 2010;10:351 pubmed publisher
    ..Finally, we discuss a model in which schizophrenia is, at least partly, a maladaptive by-product of latitude dependent adaptive changes in vitamin D metabolism. ..
  76. Valent A, Danglot G, Bernheim A. Mapping of the tyrosine kinase receptors trkA (NTRK1), trkB (NTRK2) and trkC(NTRK3) to human chromosomes 1q22, 9q22 and 15q25 by fluorescence in situ hybridization. Eur J Hum Genet. 1997;5:102-4 pubmed
    ..To resolve these conflicting results, and confirm the localization of trkB and trkC, probes specific to each of these related genes were constructed and used in fluorescent in situ hybridization on ..
  77. Armengol L, Gratacos M, Pujana M, Ribases M, Martin Santos R, Estivill X. 5' UTR-region SNP in the NTRK3 gene is associated with panic disorder. Mol Psychiatry. 2002;7:928-30 pubmed
  78. Dziuba N, Ferguson M, O Brien W, Sanchez A, Prussia A, McDonald N, et al. Identification of cellular proteins required for replication of human immunodeficiency virus type 1. AIDS Res Hum Retroviruses. 2012;28:1329-39 pubmed
    ..However, the genes presented in this study did not share identity with those found previously. Novel antiviral targets identified in this study should open new avenues for mechanistic investigation. ..
  79. Genevois A, Ichim G, Coissieux M, Lambert M, Lavial F, Goldschneider D, et al. Dependence receptor TrkC is a putative colon cancer tumor suppressor. Proc Natl Acad Sci U S A. 2013;110:3017-22 pubmed publisher
    The TrkC neurotrophin receptor belongs to the functional dependence receptor family, members of which share the ability to induce apoptosis in the absence of their ligands...
  80. Kim M, Kim G, Choi Y, Kim H, Kim Y, Jin W. TrkC promotes survival and growth of leukemia cells through Akt-mTOR-dependent up-regulation of PLK-1 and Twist-1. Mol Cells. 2013;36:177-84 pubmed publisher
    ..Here, we describe an important role of the TrkC-associated molecular network in the process of leukemogenesis...
  81. Gareeva A, Traks T, Koks S, Khusnutdinova E. [The Role of Neurotrophins and Neurexins Genes in the Risk of Paranoid Schizophrenia in Russians and Tatars]. Genetika. 2015;51:799-811 pubmed
    ..paper we investigated 48 polymorphic variants of genes of the neurotrophins and neurexins family (BDNF, NTRK2, NTRK3, NGF, NXPH1, and NRXN1) in Russian and Tatar cases and in a control group living in the Republic of Bashkortostan...
  82. Ge L, Li N, Liu M, Xu N, Wang M, Wu L. Copy number variations of neurotrophic tyrosine receptor kinase 3 (NTRK3) may predict prognosis of ovarian cancer. Medicine (Baltimore). 2017;96:e7621 pubmed publisher
    ..study evaluated the correlation between copy number variations (CNVs) of neurotrophic tyrosine receptor kinase 3 (NTRK3) and the prognosis of ovarian cancer, which might predict platinum resistance in ovarian cancer patients...
  83. Llamas Velasco M, Mentzel T, Rutten A. Primary cutaneous secretory carcinoma: A previously overlooked low-grade sweat gland carcinoma. J Cutan Pathol. 2018;45:240-245 pubmed publisher
    Twelve cases of primary cutaneous secretory carcinoma (PCSC) have been published, 9 showing ETV6-NTRK3 translocation, a characteristic finding shared with secretory breast carcinoma and mammary analogue secretory carcinoma...
  84. Mamidipudi V, Li X, Wooten M. Identification of interleukin 1 receptor-associated kinase as a conserved component in the p75-neurotrophin receptor activation of nuclear factor-kappa B. J Biol Chem. 2002;277:28010-8 pubmed
    ..Altogether, our data provide novel information regarding the proximal components involved in p75 receptor signaling and underscore the importance of the atypical PKC interacting protein p62 in this process. ..
  85. Lannon C, Martin M, Tognon C, Jin W, Kim S, Sorensen P. A highly conserved NTRK3 C-terminal sequence in the ETV6-NTRK3 oncoprotein binds the phosphotyrosine binding domain of insulin receptor substrate-1: an essential interaction for transformation. J Biol Chem. 2004;279:6225-34 pubmed
    ..The ETV6-NTRK3 (EN) gene fusion occurs in human pediatric spindle cell sarcomas and secretory breast carcinoma, and encodes the ..
  86. Fung W, Hasan M, Loh A, Chua J, Yong M, Hwee Y, et al. Gene expression of TRK neurotrophin receptors in advanced neuroblastomas in Singapore--a pilot study. Pediatr Hematol Oncol. 2011;28:571-8 pubmed publisher
    ..Tyrosine kinase neurotrophin receptors (Trks, including TrkA, TrkB, and TrkC) are important in the clinical and biological behavior of neuroblastomas...
  87. Urano M, Nagao T, Miyabe S, Ishibashi K, Higuchi K, Kuroda M. Characterization of mammary analogue secretory carcinoma of the salivary gland: discrimination from its mimics by the presence of the ETV6-NTRK3 translocation and novel surrogate markers. Hum Pathol. 2015;46:94-103 pubmed publisher
    Mammary analogue secretory carcinoma (MASC) is a recently recognized salivary gland tumor harboring an ETV6-NTRK3 translocation similar to secretory carcinoma of the breast...
  88. Pavlick D, Schrock A, Malicki D, Stephens P, Kuo D, Ahn H, et al. Identification of NTRK fusions in pediatric mesenchymal tumors. Pediatr Blood Cancer. 2017;64: pubmed publisher
    ..2 years old for which infantile fibrosarcoma was considered as a diagnosis, and two harbored the canonical ETV6-NTRK3. The remaining cases carried other diagnoses, at least one that carried the diagnosis of inflammatory ..
  89. Shinwari Z, Al Hindi H, Al Shail E, Khafaga Y, Al Kofide A, El Kum N, et al. Response of medulloblastoma cells to vincristine and lomustine: role of TRKC, CTNNB1 and STK15. Anticancer Res. 2011;31:1721-33 pubmed
    ..protein beta 1 (CTNNB1) and Aurora kinase A (STK15) proteins and neurotrophic tyrosine kinase receptor type 3 (TRKC) mRNA and the proportion of apoptosis induced by vincristine, the combination of both drugs, and lomustine, ..
  90. Webb R, Gallegos Cárdenas A, Miller C, Solomotis N, Liu H, West F, et al. Pig Induced Pluripotent Stem Cell-Derived Neural Rosettes Parallel Human Differentiation Into Sensory Neural Subtypes. Cell Reprogram. 2017;19:88-94 pubmed publisher
    ..BRN3A-positive sensory cells and increased expression of sensory neuron TRK receptor gene family: TRKA, TRKB, and TRKC. Porcine sensory neural cells would allow determination of parallels between human and porcine cells in response to ..
  91. Kong B, Liu Y, Lu X. Decreased expression of neurotrophic tyrosine receptor kinase 3 is associated with the outflow tract defect of human tetralogy of Fallot. Chin Med J (Engl). 2009;122:153-7 pubmed
    ..Animal models have suggested that neurotrophic tyrosine receptor kinase 3 (NTRK3) might be associated with the outflow tract defect, similar to that seen in human TOF, however, the expression ..
  92. Yamamoto H, Yoshida A, Taguchi K, Kohashi K, Hatanaka Y, Yamashita A, et al. ALK, ROS1 and NTRK3 gene rearrangements in inflammatory myofibroblastic tumours. Histopathology. 2016;69:72-83 pubmed publisher
    ..We investigated anaplastic lymphoma kinase (ALK), ROS1, ETV6, NTRK3 and RET in 36 cases of IMT by using immunohistochemical (IHC) staining, fluorescence in-situ hybridization, and ..