Gene Symbol: NRBP
Description: nuclear receptor binding protein 1
Alias: BCON3, MADM, MUDPNP, NRBP, nuclear receptor-binding protein, multiple domain putative nuclear protein, myeloid leukemia factor 1 adaptor molecule
Species: human
Products:     NRBP

Top Publications

  1. Wang H, Sun X, Luo Y, Lin Z, Wu J. Adapter protein NRBP associates with Jab1 and negatively regulates AP-1 activity. FEBS Lett. 2006;580:6015-21 pubmed
    ..We show here that Jab1 interacts in vivo with nuclear receptor binding protein (NRBP), an evolutionarily conserved adapter protein with a kinase-like domain...
  2. Hooper J, Baker E, Ogbourne S, Sutherland G, Antalis T. Cloning of the cDNA and localization of the gene encoding human NRBP, a ubiquitously expressed, multidomain putative adapter protein. Genomics. 2000;66:113-8 pubmed
    ..Here we have identified a novel human cDNA encoding NRBP, a multidomain putative adapter protein containing (i) two putative nuclear receptor binding motifs (LXXLL), (ii) a ..
  3. Mahrour N, Redwine W, Florens L, Swanson S, Martin Brown S, Bradford W, et al. Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases. J Biol Chem. 2008;283:8005-13 pubmed publisher
    ..Taken together, our findings shed new light on the mechanisms by which BC-box proteins direct recruitment of Cullin-Rbx modules during reconstitution of ubiquitin ligases. ..
  4. Zanetti D, Rao A, Gustafsson S, Assimes T, Montgomery S, Ingelsson E. Identification of 22 novel loci associated with urinary biomarkers of albumin, sodium, and potassium excretion. Kidney Int. 2019;95:1197-1208 pubmed publisher
  5. Henner A, Ventura P, Jiang Y, Zong H. MADM-ML, a mouse genetic mosaic system with increased clonal efficiency. PLoS ONE. 2013;8:e77672 pubmed publisher
    Mosaic Analysis with Double Markers (MADM) is a mouse genetic system that allows simultaneous gene knockout and fluorescent labeling of sparse, clonally-related cells within an otherwise normal mouse, thereby circumventing embryonic ..
  6. Hippenmeyer S, Youn Y, Moon H, Miyamichi K, Zong H, Wynshaw Boris A, et al. Genetic mosaic dissection of Lis1 and Ndel1 in neuronal migration. Neuron. 2010;68:695-709 pubmed publisher
    ..Here, we extend mosaic analysis with double markers (MADM) to mouse chromosome 11 where Lis1, Ndel1, and 14-3-3ɛ (encoding a LIS1/NDEL1 signaling partner) are located...
  7. Costantini F. Generating Genetic Mosaic Mouse Embryos or Organoids for Studies of Kidney Development. Methods Mol Biol. 2019;1926:3-21 pubmed publisher
    ..3) generation of a knockout allele with a built-in reporter gene, (4) mosaic analysis with double markers (MADM), and (5) mosaic mutant analysis with spatial and temporal control of recombination (MASTR)...
  8. Erfani S, Danesh S, Karrabi S, Gheibi M, Nemati S. Statistical analysis of effective variables on the performance of waste storage service using geographical information system and response surface methodology. J Environ Manage. 2019;235:453-462 pubmed publisher
    ..The final response was achieved through integration of effective parameters by two different MADM methods, TOPSIS and OWA...
  9. Vedam S, Stoll K, McRae D, Korchinski M, Velasquez R, Wang J, et al. Patient-led decision making: Measuring autonomy and respect in Canadian maternity care. Patient Educ Couns. 2019;102:586-594 pubmed publisher
    ..Using the Mothers Autonomy in Decision-Making (MADM) scale as an outcome measure in a mixed-effects analysis, we examined differential experiences by socio-demographic ..

More Information


  1. Molzan M, Ottmann C. Subcellular localization of full-length human myeloid leukemia factor 1 (MLF1) is independent of 14-3-3 proteins. Cell Mol Biol Lett. 2013;18:137-48 pubmed publisher
    ..of MLF1 is limited and mostly derived from studies identifying MLF1 interaction partners like CSN3, MLF1IP, MADM, Manp and the 14-3-3 proteins...
  2. Hippenmeyer S, Johnson R, Luo L. Mosaic analysis with double markers reveals cell-type-specific paternal growth dominance. Cell Rep. 2013;3:960-7 pubmed publisher
    ..We used mosaic analysis with double markers (MADM) in mice to create uniparental disomies (UPDs) and to visualize imprinting effects with single-cell resolution...
  3. Mihalas A, Hevner R. Clonal analysis reveals laminar fate multipotency and daughter cell apoptosis of mouse cortical intermediate progenitors. Development. 2018;145: pubmed publisher
    ..Here, we employed mosaic analysis with double markers (MADM) in mice to sparsely label early IP clones. Most early IPs produced 1-2 neurons for deep layers only...
  4. Renauer P, Saruhan Direskeneli G, Coit P, Adler A, Aksu K, Keser G, et al. Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study. Arthritis Rheumatol. 2015;67:1361-8 pubmed publisher
    ..Our findings indicate novel genetic susceptibility loci for Takayasu arteritis and uncover potentially important aspects of the pathophysiology of this form of vasculitis. ..
  5. Yan C, Lu Y, Tang S, Fan W. MiR-519d inhibits prostate cancer cell proliferation, cycle and invasion via targeting NRBP1. Eur Rev Med Pharmacol Sci. 2018;22:2985-2990 pubmed publisher
    ..MiR-519d can repress the proliferation, cycle, and invasion of prostate cancer PC3 cells by inhibiting NRBP1. ..
  6. Maggio A, Gabriele D, Garibaldi E, Bresciani S, Delmastro E, Di Dia A, et al. Impact of a rectal and bladder preparation protocol on prostate cancer outcome in patients treated with external beam radiotherapy. Strahlenther Onkol. 2017;: pubmed publisher
    ..and comfortably full bladder (RBP) preparation protocol, while for 319 patients no rectal/bladder preparation (NRBP) protocol was adopted...
  7. Muzumdar M, Dorans K, Chung K, Robbins R, Tammela T, Gocheva V, et al. Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers. Nat Commun. 2016;7:12685 pubmed publisher
    ..Here we leverage mosaic analysis with double markers (MADM) to trace subclonal populations retaining or lacking p53 within oncogenic Kras-initiated lung and pancreatic ..
  8. Huijbers M, Spinhoven P, Spijker J, Ruhé H, van Schaik D, van Oppen P, et al. Adding mindfulness-based cognitive therapy to maintenance antidepressant medication for prevention of relapse/recurrence in major depressive disorder: Randomised controlled trial. J Affect Disord. 2015;187:54-61 pubmed publisher
    Mindfulness-based cognitive therapy (MBCT) and maintenance antidepressant medication (mADM) both reduce the risk of relapse in recurrent depression, but their combination has not been studied...
  9. Liao Y, Yang Z, Huang J, Chen H, Xiang J, Li S, et al. Nuclear receptor binding protein 1 correlates with better prognosis and induces caspase-dependent intrinsic apoptosis through the JNK signalling pathway in colorectal cancer. Cell Death Dis. 2018;9:436 pubmed publisher
    b>Nuclear receptor binding protein 1 (NRBP1) is a ubiquitously expressed and highly conserved pseudokinase that has important roles in cellular homoeostasis...
  10. Beattie R, Postiglione M, Burnett L, Laukoter S, Streicher C, Pauler F, et al. Mosaic Analysis with Double Markers Reveals Distinct Sequential Functions of Lgl1 in Neural Stem Cells. Neuron. 2017;94:517-533.e3 pubmed publisher
    ..By using mosaic analysis with double markers (MADM)-based genetic paradigms enabling the sparse and global knockout with unprecedented single-cell resolution, we ..
  11. Zhou D, Xu J, Wang L, Lin Z, Liu L. Identifying and managing risk factors for salt-affected soils: a case study in a semi-arid region in China. Environ Monit Assess. 2015;187:421 pubmed publisher
    ..We proposed to integrate spatial autoregressive (SAR) model, multi-attribute decision making (MADM), and analytic hierarchy process (AHP) for these purposes...
  12. Qi W, Yan Y, Pfeifer D, Donner V Gromoff E, Wang Y, Maier W, et al. C. elegans DAF-16/FOXO interacts with TGF-ß/BMP signaling to induce germline tumor formation via mTORC1 activation. PLoS Genet. 2017;13:e1006801 pubmed publisher
    ..In addition to activating MADM/NRBP/hpo-11 gene alone, DAF-16 also directly interacts with both R-SMAD proteins SMA-2 and SMA-3 in the nucleus to ..
  13. Zhang L, Ge C, Zhao F, Zhang Y, Wang X, Yao M, et al. NRBP2 Overexpression Increases the Chemosensitivity of Hepatocellular Carcinoma Cells via Akt Signaling. Cancer Res. 2016;76:7059-7071 pubmed
    ..In this study, we found that nuclear receptor binding protein 2 (NRBP2) expression was downregulated in the CD133+ hepatocellular carcinoma CSCs...
  14. Huijbers M, Spinhoven P, van Schaik D, Nolen W, Speckens A. Patients with a preference for medication do equally well in mindfulness-based cognitive therapy for recurrent depression as those preferring mindfulness. J Affect Disord. 2016;195:32-9 pubmed publisher
    ..whether preference for either mindfulness-based cognitive therapy (MBCT) or maintenance antidepressant medication (mADM) to prevent relapse in recurrent depression was associated with patients' characteristics, treatment adherence, or ..
  15. Huijbers M, Spinhoven P, Spijker J, Ruhe H, van Schaik D, van Oppen P, et al. Discontinuation of antidepressant medication after mindfulness-based cognitive therapy for recurrent depression: randomised controlled non-inferiority trial. Br J Psychiatry. 2016;208:366-73 pubmed publisher
    Mindfulness-based cognitive therapy (MBCT) and maintenance antidepressant medication (mADM) both reduce the risk of relapse in recurrent depression, but their combination has not been studied...
  16. Liu K, Lin S, Hsieh J, Tzeng G. Improving the food waste composting facilities site selection for sustainable development using a hybrid modified MADM model. Waste Manag. 2018;75:44-59 pubmed publisher
    ..It is basically a multiple attribute decision making (MADM) issue, a difficult problem which has been obsessing the governments of many countries is widely studied and ..
  17. Riccio P, Cebrian C, Zong H, Hippenmeyer S, Costantini F. Ret and Etv4 Promote Directed Movements of Progenitor Cells during Renal Branching Morphogenesis. PLoS Biol. 2016;14:e1002382 pubmed publisher
    ..Here, we use Mosaic Analysis with Double Markers (MADM), combined with organ culture and time-lapse imaging, to trace the movements and divisions of individual ureteric ..
  18. Akhtar A, Park H, Breunig J. Lethal Giant Lineage Tracing: Mutating Locally, Acting Globally. Neuron. 2017;94:417-420 pubmed publisher
    ..In this issue of Neuron, Beattie et al. (2017) use elegant MADM-based lineage tracing to demonstrate cell-intrinsic and global functions for Lgl1 during neocortical development.
  19. Singh S, Liu Y, Zhao J, Zeng X, Hou S. The novel tumour suppressor Madm regulates stem cell competition in the Drosophila testis. Nat Commun. 2016;7:10473 pubmed publisher
    ..However, little is known about the underlying molecular mechanism. Here we identify Mlf1-adaptor molecule (Madm), a novel tumour suppressor that regulates the competition between germline stem cells (GSCs) and somatic cyst stem ..
  20. Yuyun M, Narayan H, Quinn P, Struck J, Bergmann A, Hartmann O, et al. Prognostic value of human mature adrenomedullin in patients with acute myocardial infarction. J Cardiovasc Med (Hagerstown). 2017;18:42-50 pubmed
    ..Measurement of human mature ADM (mADM) has been difficult, and recent studies have used its surrogate - the mid-regional pro-ADM (MRproADM)...
  21. Chandrani P, Upadhyay P, Iyer P, Tanna M, Shetty M, Raghuram G, et al. Integrated genomics approach to identify biologically relevant alterations in fewer samples. BMC Genomics. 2015;16:936 pubmed publisher
    ..Of these, we find a heterozygous truncating mutation in Nuclear receptor binding protein, NRBP1 pseudokinase gene, identical to as reported in other cancers, is oncogenic when ectopically ..
  22. Nie Y, Li Q, Amcheslavsky A, Duhart J, Veraksa A, Stocker H, et al. Bunched and Madm Function Downstream of Tuberous Sclerosis Complex to Regulate the Growth of Intestinal Stem Cells in Drosophila. Stem Cell Rev. 2015;11:813-25 pubmed publisher
    ..We show here that the leucine zipper protein Bunched and the adaptor protein Madm are novel regulators of intestinal stem cells...
  23. Wang L, Li X, Liu Y, Gui G. Data-Prefetching Scheme Based on Playback Delay and Positioning Satisfaction in Peer-To-Peer Video-On-Demand System. Sensors (Basel). 2018;18: pubmed publisher
    ..According to the DSA, we use the multiple-attribute decision-making (MADM) theory to model the selection of intervals of prefetching data blocks (i.e...
  24. Moridi P, Atabi F, Nouri J, Yarahmadi R. Selection of optimized air pollutant filtration technologies for petrochemical industries through multiple-attribute decision-making. J Environ Manage. 2017;197:456-463 pubmed publisher
    ..technologies for air filtration devices in petrochemical industries through a multi-criteria decision-making (MADM) method based on a fuzzy model of Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS)...
  25. Hosseinzade Z, Pagsuyoin S, Ponnambalam K, Monem M. Decision-making in irrigation networks: Selecting appropriate canal structures using multi-attribute decision analysis. Sci Total Environ. 2017;601-602:177-185 pubmed publisher
    ..In this paper, we apply multi-attribute decision making (MADM) methodology to develop a decision analysis (DA) framework for evaluating, ranking and selecting check and intake ..
  26. Martinez P. [A nurse with the drug addicts]. Rev Infirm. 1976;26:557-62 pubmed
  27. Liu Y, Chen Y, Tzeng G. Identification of key factors in consumers' adoption behavior of intelligent medical terminals based on a hybrid modified MADM model for product improvement. Int J Med Inform. 2017;105:68-82 pubmed publisher
    ..A hybrid modified Multiple Attribute Decision-Making (MADM) model was used for this study, based on three components: (1) the Decision-Making Trial and Evaluation Laboratory (..
  28. Parida P, Yadav R, Dehury B, Ghosh D, Mahapatra N, Mohanta T. Novel insights into the molecular interaction of a Panduratin A derivative with the Non Structural protein (NS3) of dengue serotypes: A molecular dynamics study. Curr Pharm Biotechnol. 2017;: pubmed publisher
    ..hydrate) has been observed to block the Nuclear Receptor Binding Protein binding site of Non Structural protein 3 in all dengue serotypes...
  29. Li B, Pei Y, Wu H, Huang D. MADM-based smart parking guidance algorithm. PLoS ONE. 2017;12:e0188283 pubmed publisher
    ..Based on the multiple attributes decision making (MADM) theory, this study proposed a smart parking guidance algorithm by considering three representative decision ..
  30. Parida P, Yadav R, Sarma K. Insight into structural organization and protein-protein interaction of non structural 3 (NS3) proteins from dengue serotypes. Curr Pharm Biotechnol. 2014;15:156-72 pubmed
    ..NS3 protein of dengue virus interacts with nuclear receptor binding protein (NRBP) of human causing cell trafficking between the Endoplasmic Reticulum (ER) and Golgi, which ..
  31. Kudoh A, Takahama S, Sawasaki T, Ode H, Yokoyama M, Okayama A, et al. The phosphorylation of HIV-1 Gag by atypical protein kinase C facilitates viral infectivity by promoting Vpr incorporation into virions. Retrovirology. 2014;11:9 pubmed publisher
    ..Furthermore, aPKC inhibition efficiently suppresses HIV-1 infectivity in macrophages. aPKC may therefore be an intriguing therapeutic target for HIV-1 infection. ..
  32. Parida P, Yadav R, Sarma K, Nainwal L. Design, virtual screening and docking study of novel NS3 inhibitors by targeting protein-protein interacting sites of dengue virus - a novel approach. Curr Pharm Biotechnol. 2013;14:995-1008 pubmed
    ..Targeting this we performed homology modeling and protein-protein docking study of NS3 with NRBP (Nuclear Receptor Binding Protein) of human as it has been proved that NS3 of DENV interacts with NRBP which causes cellular ..
  33. Wilson C, Crombie C, van der Weyden L, Poulogiannis G, Rust A, Pardo M, et al. Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. EMBO J. 2012;31:2486-97 pubmed publisher
    ..Nrbp1 results in tumourigenesis, with haematological and intestinal tumours predominating, and that nuclear receptor binding protein 1 (NRBP1) is downregulated in a range of human tumours, where low expression correlates with a poor ..
  34. De Langhe S, Haataja L, Senadheera D, Groffen J, Heisterkamp N. Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. Int J Mol Med. 2002;9:451-9 pubmed
    ..We here identify human NRBP as a Rac family-interacting protein. NRBP formed a complex with activated Rac3...
  35. Ruiz C, Oeggerli M, Germann M, Gluderer S, Stocker H, Andreozzi M, et al. High NRBP1 expression in prostate cancer is linked with poor clinical outcomes and increased cancer cell growth. Prostate. 2012;72:1678-87 pubmed publisher
    We recently established the rationale that NRBP1 (nuclear receptor binding protein 1) has a potential growth-promoting role in cell biology...
  36. Lim R, Winteringham L, Williams J, McCulloch R, Ingley E, Tiao J, et al. MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1. J Biol Chem. 2002;277:40997-1008 pubmed
    ..Two proteins isolated in this screen were 14-3-3zeta and a novel adaptor, Madm. Mlf1 contains a classic RSXSXP sequence for 14-3-3 binding and is associated with 14-3-3zeta via this ..
  37. Zhu Z, Meng W, Liu P, Zhu X, Liu Y, Zou H. DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene NRBP1 upregulates its expression by inhibition of TFAP2A binding. Clin Epigenetics. 2017;9:99 pubmed publisher
    ..This study sought to understand the molecular mechanism of a common genetic variant, rs780093, in the development of gout, both in vitro and in vivo...
  38. Liu J, Wu X, Zeng S, Pan T. Intuitionistic Linguistic Multiple Attribute Decision-Making with Induced Aggregation Operator and Its Application to Low Carbon Supplier Selection. Int J Environ Res Public Health. 2017;14: pubmed publisher
    The main focus of this paper is to investigate the multiple attribute decision making (MADM) method under intuitionistic linguistic (IL) environment, based on induced aggregation operators and analyze possibilities for its application in ..
  39. Chua J, Ng M, Chow V. The non-structural 3 (NS3) protein of dengue virus type 2 interacts with human nuclear receptor binding protein and is associated with alterations in membrane structure. Virus Res. 2004;102:151-63 pubmed publisher
    ..analyses, we demonstrated that the NS3 protein of dengue virus type 2 interacted specifically with nuclear receptor binding protein (NRBP), a host cellular protein that influences trafficking between the endoplasmic reticulum (ER) ..
  40. Lv D, Jia F, Hou Y, Sang Y, Alvarez A, Zhang W, et al. Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding. Cancer Res. 2017;77:6190-6201 pubmed publisher
    ..investigations demonstrated that KAT6A acetylates lysine 23 of histone H3 (H3K23), which recruits the nuclear receptor binding protein TRIM24 to activate PIK3CA transcription, thereby enhancing PI3K/AKT signaling and ..