Gene Symbol: NR3C2
Description: nuclear receptor subfamily 3 group C member 2
Alias: MCR, MLR, NR3C2VIT, mineralocorticoid receptor, aldosterone receptor, mineralocorticoid receptor 1, mineralocorticoid receptor 2, mineralocorticoid receptor delta, nuclear receptor subfamily 3, group C, member 2 variant 3
Species: human
Products:     NR3C2

Top Publications

  1. Geller D, Farhi A, Pinkerton N, Fradley M, Moritz M, Spitzer A, et al. Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy. Science. 2000;289:119-23 pubmed
    ..We describe a mutation in the mineralocorticoid receptor (MR), S810L, that causes early-onset hypertension that is markedly exacerbated in pregnancy...
  2. Tajima T, Kitagawa H, Yokoya S, Tachibana K, Adachi M, Nakae J, et al. A novel missense mutation of mineralocorticoid receptor gene in one Japanese family with a renal form of pseudohypoaldosteronism type 1. J Clin Endocrinol Metab. 2000;85:4690-4 pubmed
    ..two frame shift mutations, two premature termination codons, and one splice site mutation in the mineralocorticoid receptor (MR) gene were identified...
  3. Viemann M, Peter M, López Siguero J, Simic Schleicher G, Sippell W. Evidence for genetic heterogeneity of pseudohypoaldosteronism type 1: identification of a novel mutation in the human mineralocorticoid receptor in one sporadic case and no mutations in two autosomal dominant kindreds. J Clin Endocrinol Metab. 2001;86:2056-9 pubmed
    ..Mutations in the gene encoding the human mineralocorticoid receptor (hMR) are, at least in some patients, responsible for the latter form of PHA1...
  4. van Leeuwen N, Kumsta R, Entringer S, de Kloet E, Zitman F, DeRijk R, et al. Functional mineralocorticoid receptor (MR) gene variation influences the cortisol awakening response after dexamethasone. Psychoneuroendocrinology. 2010;35:339-49 pubmed publisher
    ..The association of the CAR with functional MR gene variants only in dexamethasone treated subjects suggests the involvement of MR in dexamethasone induced suppression of morning cortisol. ..
  5. Kuningas M, de Rijk R, Westendorp R, Jolles J, Slagboom P, van Heemst D. Mental performance in old age dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors. Neuropsychopharmacology. 2007;32:1295-301 pubmed
    ..In contrast, these genetic variants in the MR and GR genes do not influence cognitive functioning in old age. ..
  6. Di Fabio F, Alvarado C, Majdan A, Gologan A, Voda L, Mitmaker E, et al. Underexpression of mineralocorticoid receptor in colorectal carcinomas and association with VEGFR-2 overexpression. J Gastrointest Surg. 2007;11:1521-8 pubmed
    The human mineralocorticoid receptor (MR) is a steroid receptor widely expressed in colorectal mucosa...
  7. Zennaro M, Farman N, Bonvalet J, Lombes M. Tissue-specific expression of alpha and beta messenger ribonucleic acid isoforms of the human mineralocorticoid receptor in normal and pathological states. J Clin Endocrinol Metab. 1997;82:1345-52 pubmed
    Expression of the mineralocorticoid receptor (MR) is restricted to some sodium-transporting epithelia and a few nonepithelial target tissues...
  8. van Leeuwen N, Bellingrath S, de Kloet E, Zitman F, DeRijk R, Kudielka B, et al. Human mineralocorticoid receptor (MR) gene haplotypes modulate MR expression and transactivation: implication for the stress response. Psychoneuroendocrinology. 2011;36:699-709 pubmed publisher
    ..These effects exerted by corticosteroids are mediated by two brain corticosteroid receptor types, the mineralocorticoid receptor (MR), with a high affinity already occupied under basal conditions and the glucocorticoid receptor (GR), ..
  9. Balsamo A, Cicognani A, Gennari M, Sippell W, Menabò S, Baronio F, et al. Functional characterization of naturally occurring NR3C2 gene mutations in Italian patients suffering from pseudohypoaldosteronism type 1. Eur J Endocrinol. 2007;156:249-56 pubmed
    The renal form of pseudohypoaldosteronism type 1 (PHA1) is a rare disease caused by mutations in the human mineralocorticoid receptor gene (NR3C2).

More Information

Publications115 found, 100 shown here

  1. Bogdan R, Perlis R, Fagerness J, Pizzagalli D. The impact of mineralocorticoid receptor ISO/VAL genotype (rs5522) and stress on reward learning. Genes Brain Behav. 2010;9:658-67 pubmed publisher
    Research suggests that stress disrupts reinforcement learning and induces anhedonia. The mineralocorticoid receptor (MR) determines the sensitivity of the stress response, and the missense iso/val polymorphism (Ile180Val, rs5522) of the ..
  2. Geller D, Rodriguez Soriano J, Vallo Boado A, Schifter S, Bayer M, Chang S, et al. Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I. Nat Genet. 1998;19:279-81 pubmed
    ..As ENaC activity in the kidney is regulated by the steroid hormone aldosterone acting through the mineralocorticoid receptor, we have screened the mineralocorticoid receptor gene (MLR) for variants and have identified ..
  3. Klok M, Alt S, Irurzun Lafitte A, Turner J, Lakke E, Huitinga I, et al. Decreased expression of mineralocorticoid receptor mRNA and its splice variants in postmortem brain regions of patients with major depressive disorder. J Psychiatr Res. 2011;45:871-8 pubmed publisher
    Appropriate signaling in the brain by the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) is critical in regulation of the hypothalamic-pituitary-adrenal (HPA) axis, emotional arousal and cognitive performance...
  4. Sartorato P, Lapeyraque A, Armanini D, Kuhnle U, Khaldi Y, Salomon R, et al. Different inactivating mutations of the mineralocorticoid receptor in fourteen families affected by type I pseudohypoaldosteronism. J Clin Endocrinol Metab. 2003;88:2508-17 pubmed
    We have analyzed the human mineralocorticoid receptor (hMR) gene in 14 families with autosomal dominant or sporadic pseudohypoaldosteronism (PHA1), a rare form of mineralocorticoid resistance characterized by neonatal renal salt wasting ..
  5. Yang J, Fuller P. Interactions of the mineralocorticoid receptor--within and without. Mol Cell Endocrinol. 2012;350:196-205 pubmed publisher
    ..This review will discuss the current understanding of interactions involving the MR and highlight their relevance to ligand- or tissue-specificity as well as their suitability as therapeutic targets. ..
  6. DeRijk R, Wüst S, Meijer O, Zennaro M, Federenko I, Hellhammer D, et al. A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness. J Clin Endocrinol Metab. 2006;91:5083-9 pubmed
    ..These differences were not observed using aldosterone as a ligand. The findings reveal that cortisol and heart rate responses to a psychosocial stressor are enhanced in carriers of the MR180V variant. ..
  7. Arai K, Nakagomi Y, Iketani M, Shimura Y, Amemiya S, Ohyama K, et al. Functional polymorphisms in the mineralocorticoid receptor and amirolide-sensitive sodium channel genes in a patient with sporadic pseudohypoaldosteronism. Hum Genet. 2003;112:91-7 pubmed infancy resulting from a congenital resistance to aldosterone involving the genes for the mineralocorticoid receptor (MR) and the amiloride-sensitive sodium channel (ENaC)...
  8. Klok M, Vreeburg S, Penninx B, Zitman F, de Kloet E, DeRijk R. Common functional mineralocorticoid receptor polymorphisms modulate the cortisol awakening response: Interaction with SSRIs. Psychoneuroendocrinology. 2011;36:484-94 pubmed publisher
    ..This suggests that effect of SSRIs on cortisol regulation depends in part on the MR genotype with possible implications for future treatment selection. ..
  9. Pujo L, Fagart J, Gary F, Papadimitriou D, Claës A, Jeunemaitre X, et al. Mineralocorticoid receptor mutations are the principal cause of renal type 1 pseudohypoaldosteronism. Hum Mutat. 2007;28:33-40 pubmed
    ..Inactivating mutations of the mineralocorticoid receptor (MR; NR3C2) are responsible for autosomal dominant and some sporadic cases of PHA1...
  10. Pippal J, Yao Y, Rogerson F, Fuller P. Structural and functional characterization of the interdomain interaction in the mineralocorticoid receptor. Mol Endocrinol. 2009;23:1360-70 pubmed publisher
    The mineralocorticoid receptor (MR) plays a central role in electrolyte homeostasis and in cardiovascular disease. We have previously reported a ligand-dependent N/C-interaction in the MR...
  11. Riepe F, Finkeldei J, de Sanctis L, Einaudi S, Testa A, Karges B, et al. Elucidating the underlying molecular pathogenesis of NR3C2 mutants causing autosomal dominant pseudohypoaldosteronism type 1. J Clin Endocrinol Metab. 2006;91:4552-61 pubmed
    Pseudohypoaldosteronism type 1 (PHA1) is a rare salt-wasting syndrome. Mutations in the NR3C2 gene coding for the mineralocorticoid receptor (MR) cause autosomal dominant PHA1.
  12. Riepe F, Krone N, Morlot M, Ludwig M, Sippell W, Partsch C. Identification of a novel mutation in the human mineralocorticoid receptor gene in a german family with autosomal-dominant pseudohypoaldosteronism type 1: further evidence for marked interindividual clinical heterogeneity. J Clin Endocrinol Metab. 2003;88:1683-6 pubmed
    ..It remains to be elucidated whether other defects or polymorphisms in genes coding for regulatory proteins participating in sodium homeostasis are a cause of the heterogeneity of the clinical manifestations in autosomal dominant PHA1. ..
  13. Sevilla L, Perez P. Roles of the Glucocorticoid and Mineralocorticoid Receptors in Skin Pathophysiology. Int J Mol Sci. 2018;19: pubmed publisher
    ..The GC receptor (GR/NR3C1) and the mineralocorticoid receptor (MR/NR3C2) are members of the NR subclass NR3C that are highly related, both structurally and ..
  14. Tsuji H, Wang W, Sunil J, Shimizu N, Yoshimura K, Uemura H, et al. Involvement of renin-angiotensin-aldosterone system in calcium oxalate crystal induced activation of NADPH oxidase and renal cell injury. World J Urol. 2016;34:89-95 pubmed publisher
    ..Aldosterone stimulates ROS production through activation of Nox with the involvement of mineralocorticoid receptor (MR), Rac1 and mitogen-activated protein kinases (MAPK)...
  15. Gasparini S, Resch J, Narayan S, Peltekian L, Iverson G, Karthik S, et al. Aldosterone-sensitive HSD2 neurons in mice. Brain Struct Funct. 2019;224:387-417 pubmed publisher
    ..These neurons express Hsd11b2, Nr3c2 (mineralocorticoid receptor), Agtr1a (angiotensin receptor), Slc17a6 (vesicular glutamate transporter 2), Phox2b, and Nxph4; many ..
  16. Räikkönen K, Pesonen A, O Reilly J, Tuovinen S, Lahti M, Kajantie E, et al. Maternal depressive symptoms during pregnancy, placental expression of genes regulating glucocorticoid and serotonin function and infant regulatory behaviors. Psychol Med. 2015;45:3217-26 pubmed publisher
    ..dehydrogenase type 2 (HSD2B11), type 1 (HSD1B11), glucocorticoid (NR3C1), mineralocorticoid receptors (NR3C2) and serotonin transporter (SLC6A4) were obtained from 54 healthy mothers aged 32.2 ± 5...
  17. Shashar M, Hod T, Chernichovski T, Angel A, Kazan S, Grupper A, et al. Mineralocorticoid receptor blockade improves arginine transport and nitric oxide generation through modulation of cationic amino acid transporter-1 in endothelial cells. Nitric Oxide. 2018;80:24-31 pubmed publisher
    Blockade of the mineralocorticoid receptor (MCR) has been shown to improve endothelial function far beyond blood pressure control...
  18. Martinez E, Lilyanna S, Wang P, Vardy L, Jiang X, Armugam A, et al. MicroRNA-31 promotes adverse cardiac remodeling and dysfunction in ischemic heart disease. J Mol Cell Cardiol. 2017;112:27-39 pubmed publisher
    ..that miR-31 targets the 3´UTR of cardiac troponin-T (Tnnt2), E2F transcription factor 6 (E2f6), mineralocorticoid receptor (Nr3c2) and metalloproteinase inhibitor 4 (Timp4) mRNAs...
  19. Sarubin N, Hilbert S, Naumann F, Zill P, Wimmer A, Nothdurfter C, et al. The sex-dependent role of the glucocorticoid receptor in depression: variations in the NR3C1 gene are associated with major depressive disorder in women but not in men. Eur Arch Psychiatry Clin Neurosci. 2017;267:123-133 pubmed publisher
    Genetic variations in the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR) have been associated with maladaptive stress responses and major depressive disorder (MDD)...
  20. Brooks K, Burns G, Spencer T. Biological Roles of Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1), HSD11B2, and Glucocorticoid Receptor (NR3C1) in Sheep Conceptus Elongation. Biol Reprod. 2015;93:38 pubmed publisher a biologically active glucocorticoid and ligand for the glucocorticoid receptor (NR3C1 or GR) and mineralocorticoid receptor (NR3C2 or MR)...
  21. Haas J, Weber J, Gonzalez O, Zimmer R, Griffiths S. Antiviral activity of the mineralocorticoid receptor NR3C2 against Herpes simplex virus Type 1 (HSV-1) infection. Sci Rep. 2018;8:15876 pubmed publisher
    ..RNA interference screen of host factors affecting herpes simplex virus type 1 (HSV-1) revealed that the mineralocorticoid receptor (MR) inhibits HSV-1 replication...
  22. Abramova T, Smolenskaya S, Antonov E, Redina O, Markel A. [Expression of Catechol-O-Methyltransferase (Comt), Mineralocorticoid Receptor (Mlr), and Epithelial Sodium Channel (ENaC) Genes in Kidneys of Hypertensive ISIAH Rats at Rest and during Response to Stress]. Genetika. 2016;52:206-14 pubmed
    ..A comparative study of the mRNA expression level of catechol-o-methyltransferase (Comt), mineralocorticoid receptor (Mlr), and ?-subunit of epithelial sodium channel (?-ENaC) genes was conducted on the kidneys of ..
  23. Tang M, Liu Y, Wang L, Li H, Cai H, Zhang M, et al. An ?-3 fatty acid-deficient diet during gestation induces depressive-like behavior in rats: the role of the hypothalamo-pituitary-adrenal (HPA) system. Food Funct. 2018;: pubmed publisher
    ..The protein expressions of glucocorticoid receptor (GR) and mineralocorticoid receptor (MCR) were also measured to evaluate the HPA activity...
  24. Good M, Chiu Y, Poon I, Medina C, Butcher J, Mendu S, et al. Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone. Circ Res. 2018;122:606-615 pubmed publisher
    ..Although spironolactone can act at the mineralocorticoid receptor (MR; NR3C2), there is increasing evidence of MR-independent effects of spironolactone...
  25. Young M, Rickard A. Mineralocorticoid receptors in the heart: lessons from cell-selective transgenic animals. J Endocrinol. 2015;224:R1-13 pubmed publisher
    ..Targeting the mineralocorticoid receptor (MR) offers one approach for the treatment of heart failure with current strategies for novel MR ..
  26. Poleti M, DeRijk R, Rosa A, Moncau C, Oliveira P, Coutinho L, et al. Genetic variants in glucocorticoid and mineralocorticoid receptors are associated with concentrations of plasma cortisol, muscle glycogen content, and meat quality traits in male Nellore cattle. Domest Anim Endocrinol. 2015;51:105-13 pubmed publisher
    The glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) are key components in the regulation of the hypothalamic-pituitary-adrenal neuroendocrine axis and coordinate the physiological response to stress agents to reestablish ..
  27. Patni H, Mathew J, Luan L, Franki N, Chander P, Singhal P. Aldosterone promotes proximal tubular cell apoptosis: role of oxidative stress. Am J Physiol Renal Physiol. 2007;293:F1065-71 pubmed
    ..We conclude that aldosterone-induced tubular cell apoptosis is mediated through the activation of the mitochondrial pathway and generation of ROS. ..
  28. Rebechi S, Vélez M, Vaira S, Perotti M. Adulteration of Argentinean milk fats with animal fats: Detection by fatty acids analysis and multivariate regression techniques. Food Chem. 2016;192:1025-32 pubmed publisher
    ..For each adulterant, Multiple Linear Regression (MLR) was applied, and a model was chosen and validated...
  29. Futatsubashi G, Sasada S, Ohtsuka H, Suzuki S, Komiyama T. History-dependent changes in the recovery process of the middle latency cutaneous reflex gain after ankle sprain injury. Eur J Appl Physiol. 2016;116:459-70 pubmed publisher
    ..Therefore, in the present study, we investigated the time course of the changes in the PL MLR after an ankle sprain in relation to the number of sprain recurrences...
  30. Qi S, Li N, Tuo Z, Li J, Xing S, Li B, et al. Effects of Morus root bark extract and active constituents on blood lipids in hyperlipidemia rats. J Ethnopharmacol. 2016;180:54-9 pubmed publisher
    ..This investigation aims to study the anti-hyperlipidemia effects of Mori Cortex Radicis (MCR) extracts in hyperlipidemic rat models and the potential therapeutic activities of compounds isolated from the ..
  31. Tajabadi F, Ghambarian M, Yamini Y, Yazdanfar N. Combination of hollow fiber liquid phase microextraction followed by HPLC-DAD and multivariate curve resolution to determine antibacterial residues in foods of animal origin. Talanta. 2016;160:400-409 pubmed publisher
    ..the combination of HF-LPME/HPLC-DAD second-order data with multivariate curve resolution-alternative least squares (MCR-ALS) algorithm, which improves the resolution of some overlapped chromatograms and, hence, increases the accuracy ..
  32. Purohit M, Chandran S, Shah H, Diwan V, Tamhankar A, Stålsby Lundborg C. Antibiotic Resistance in an Indian Rural Community: A 'One-Health' Observational Study on Commensal Coliform from Humans, Animals, and Water. Int J Environ Res Public Health. 2017;14: pubmed publisher
    ..Group D-type isolates with resistance genes were mainly from humans and wastewater. Colistin resistance, or the mcr-1 gene, was not detected...
  33. Head B, Patel H, Insel P. Interaction of membrane/lipid rafts with the cytoskeleton: impact on signaling and function: membrane/lipid rafts, mediators of cytoskeletal arrangement and cell signaling. Biochim Biophys Acta. 2014;1838:532-45 pubmed publisher certain glycosphingolipids, gangliosides, and sterols (such as cholesterol) to form membrane/lipid rafts (MLR)...
  34. Jee H, Park J. Selection of an optimal set of biomarkers and comparative analyses of biological age estimation models in Korean females. Arch Gerontol Geriatr. 2017;70:84-91 pubmed publisher
    ..The multiple linear regression (MLR), principal component analysis (PCA), and the Klemera-Doubal (KDM) statistical methods were applied to obtain three ..
  35. Li Q, Tang Y, Yan Z, Zhang P. Identification of trace additives in polymer materials by attenuated total reflection Fourier transform infrared mapping coupled with multivariate curve resolution. Spectrochim Acta A Mol Biomol Spectrosc. 2017;180:154-160 pubmed publisher
    Although multivariate curve resolution (MCR) has been applied to the analysis of Fourier transform infrared (FTIR) imaging, it is still problematic to determine the number of components...
  36. Abbasi M, Sadeghi Aliabadi H, Amanlou M. Prediction of new Hsp90 inhibitors based on 3,4-isoxazolediamide scaffold using QSAR study, molecular docking and molecular dynamic simulation. Daru. 2017;25:17 pubmed publisher
    ..Multiple linear regression (MLR) and genetic algorithm of partial least square (GA-PLS) methods were performed to build models to predict the ..
  37. Marathe N, Pal C, Gaikwad S, Jonsson V, Kristiansson E, Larsson D. Untreated urban waste contaminates Indian river sediments with resistance genes to last resort antibiotics. Water Res. 2017;124:388-397 pubmed publisher
    ..The recently identified mobile colistin resistance gene mcr-1 was detected only in one of the upstream samples, but not in city samples...
  38. Sakhteman A, Edraki N, Hemmateenejad B, Miri R, Foroumadi A, Shafiee A, et al. In Silico Screening of IL-1? Production Inhibitors Using Chemometric Tools. Iran J Pharm Res. 2017;16:513-524 pubmed
    ..derivatives (inhibitors of IL-1? production) and their activities were investigated by Multiple Linear Regression (MLR) technique Stepwise Regression Method (ES-SWR)...
  39. Lindschau C, Kirsch T, Klinge U, Kolkhof P, Peters I, Fiebeler A. Dehydroepiandrosterone-induced phosphorylation and translocation of FoxO1 depend on the mineralocorticoid receptor. Hypertension. 2011;58:471-8 pubmed publisher
    ..Pharmacological blockade of the mineralocorticoid receptor (MR) with eplerenone or small interfering RNA-mediated MR-silencing prevented DHEA-induced extracellular ..
  40. Zhao R, He Y. Network pharmacology analysis of the anti-cancer pharmacological mechanisms of Ganoderma lucidum extract with experimental support using Hepa1-6-bearing C57 BL/6 mice. J Ethnopharmacol. 2018;210:287-295 pubmed publisher and Predicted-Compound-Target network, 6 hub targets were screened, including AR, CHRM2, ESR1, NR3C1, NR3C2 and PGR, which was considered as potential markers and might play important roles in the process of GLE treatment...
  41. MacNair C, Stokes J, Carfrae L, Fiebig Comyn A, Coombes B, Mulvey M, et al. Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics. Nat Commun. 2018;9:458 pubmed publisher
    Plasmid-borne colistin resistance mediated by mcr-1 may contribute to the dissemination of pan-resistant Gram-negative bacteria...
  42. Ho S, Chen Y, Woo J, Lam S. High habitual calcium intake attenuates bone loss in early postmenopausal Chinese women: an 18-month follow-up study. J Clin Endocrinol Metab. 2004;89:2166-70 pubmed
    ..Our findings suggest that an intake exceeding 900 mg calcium/d was helpful in the prevention of cortical bone loss among early postmenopausal Chinese women. ..
  43. Dias L, Thodima V, Friedman J, Ma C, Guttapalli A, Mendiratta G, et al. Cross-platform assessment of genomic imbalance confirms the clinical relevance of genomic complexity and reveals loci with potential pathogenic roles in diffuse large B-cell lymphoma. Leuk Lymphoma. 2016;57:899-908 pubmed publisher
    ..associated with patient outcome across datasets, but genomic complexity, defined by imbalance in more than one MCR, significantly portended adverse outcome in two of three independent datasets...
  44. Dong J, Dai W, Xu J, Li S. Spectral Estimation Model Construction of Heavy Metals in Mining Reclamation Areas. Int J Environ Res Public Health. 2016;13: pubmed publisher
    ..the heavy metal content and spectral data by establishing quantitative models with Multivariable Linear Regression (MLR), Generalized Regression Neural Network (GRNN) and Sequential Minimal Optimization for Support Vector Machine (SMO-..
  45. Kim D, Lee H, Oh K, Ki A, Protzman R, Kim D, et al. Exploration of the metal coordination region of concanavalin A for its interaction with human norovirus. Biomaterials. 2017;128:33-43 pubmed publisher
    ..metal coordinated region of Con A, which spans Asp16 to His24, is converted to nine alanine residues (mCon AMCR), the affinity for HuNoV (GII...
  46. Ritchie E, Martin E, Racher A, Jaques C. Extraction of indirectly captured information for use in a comparison of offline pH measurement technologies. J Biotechnol. 2017;251:160-165 pubmed publisher
    ..02pH. A new variable, OsmoRes, was created using multiple linear regression (MLR) to extract information indirectly captured in the recorded measurements for osmolality...
  47. Pineda S, Van Steen K, Malats N. Integrative eQTL analysis of tumor and host omics data in individuals with bladder cancer. Genet Epidemiol. 2017;41:567-573 pubmed publisher
    ..We further compared our strategy with two 2SR-approaches, one using multiple linear regression (2SR-MLR) and other using LASSO (2SR-LASSO)...
  48. Tirard M, Almeida O, Hutzler P, Melchior F, Michaelidis T. Sumoylation and proteasomal activity determine the transactivation properties of the mineralocorticoid receptor. Mol Cell Endocrinol. 2007;268:20-9 pubmed
    ..The data suggest that the overall transcriptional activity of MR can be modulated by its sumoylation potential as well as the sumoylation level of MR-interacting proteins, and requires the continuous function of the proteasome. ..
  49. Domingo Almenara X, Perera A, Ramírez N, Cañellas N, Correig X, Brezmes J. Compound identification in gas chromatography/mass spectrometry-based metabolomics by blind source separation. J Chromatogr A. 2015;1409:226-33 pubmed publisher
    ..Multivariate curve resolution-alternating least squares (MCR-ALS) is the most frequently reported technique for that purpose...
  50. Zhu S, Wan L, Yang H, Cheng J, Lu X. Cloning and high level expression of the biologically active extracellular domain of Macaca mulatta CD40 in Pichia pastoris. Protein Expr Purif. 2016;119:19-26 pubmed publisher
    ..Additionally, mmCD40Ig only showed mild immunosuppressive activity in a one-way mixed lymphocyte reaction (MLR) system. These results suggest that mmCD40Ig secreted by P...
  51. Cook D, Burnham M, Harmes D, Stoll D, Rutan S. Comparison of multivariate curve resolution strategies in quantitative LCxLC: Application to the quantification of furanocoumarins in apiaceous vegetables. Anal Chim Acta. 2017;961:49-58 pubmed publisher chemometric curve resolution techniques such as multivariate curve resolution-alternating least squares (MCR-ALS)...
  52. Liu Y, Wang H, Xu Y, Tu Q, Chen X. Achieving enhanced denitrification via hydrocyclone treatment on mixed liquor recirculation in the anoxic/aerobic process. Chemosphere. 2017;189:206-212 pubmed publisher
    This work presents the novel application of hydrocyclones for mixed liquor recirculation (MLR) treatment in the anoxic/aerobic (A/O) process to enhance the denitrification process...
  53. Matsui F, Inaba M, Uchida K, Nishio A, Fukui T, Yoshimura H, et al. Induction of PIR-A/B+ DCs in the in vitro inflammatory condition and their immunoregulatory function. J Gastroenterol. 2018;53:1131-1141 pubmed publisher
    ..and the cells acted as a negative immunoregulator when examined in an allogenic mixed leukocyte reaction (MLR)...
  54. Grossmann C, Krug A, Freudinger R, Mildenberger S, Voelker K, Gekle M. Aldosterone-induced EGFR expression: interaction between the human mineralocorticoid receptor and the human EGFR promoter. Am J Physiol Endocrinol Metab. 2007;292:E1790-800 pubmed
    ..development of fibrosis and vascular dysfunction, upregulation of EGFR expression by aldosterone-bound mineralocorticoid receptor (MR) is an attractive hypothesis...
  55. Gomez Sanchez E. The mammalian mineralocorticoid receptor: tying down a promiscuous receptor. Exp Physiol. 2010;95:13-8 pubmed publisher
    The mineralocorticoid receptor (MR) has been called a promiscuous receptor because its intrinsic affinity for aldosterone, cortisol and corticosterone is similar...
  56. Thoe W, Choi K, Lee J. Predicting 'very poor' beach water quality gradings using classification tree. J Water Health. 2016;14:97-108 pubmed publisher
    A beach water quality prediction system has been developed in Hong Kong using multiple linear regression (MLR) models...
  57. Neves A, Tauler R, de Lima K. Area correlation constraint for the MCR-ALS quantification of cholesterol using EEM fluorescence data: A new approach. Anal Chim Acta. 2016;937:21-8 pubmed publisher
    ..the use of a new additional constraint for the Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) algorithm called "area correlation constraint", introduced to build calibration models for Excitation Emission ..
  58. Ortiz Villanueva E, Benavente F, Pina B, Sanz Nebot V, Tauler R, Jaumot J. Knowledge integration strategies for untargeted metabolomics based on MCR-ALS analysis of CE-MS and LC-MS data. Anal Chim Acta. 2017;978:10-23 pubmed publisher
    In this work, two knowledge integration strategies based on multivariate curve resolution alternating least squares (MCR-ALS) were used for the simultaneous analysis of data from two metabolomic platforms...
  59. Giordano C, Barnini S, Tsioutis C, Chlebowicz M, Scoulica E, Gikas A, et al. Expansion of KPC-producing Klebsiella pneumoniae with various mgrB mutations giving rise to colistin resistance: the role of ISL3 on plasmids. Int J Antimicrob Agents. 2018;51:260-265 pubmed publisher
    b>mcr-1 has been reported as the first plasmid-encoded gene conferring colistin resistance. In KPC-producing Klebsiella pneumoniae (KPC-KP), however, colistin resistance is rapidly emerging through other mechanisms...
  60. Walther R, Atlas E, Carrigan A, Rouleau Y, Edgecombe A, Visentin L, et al. A serine/threonine-rich motif is one of three nuclear localization signals that determine unidirectional transport of the mineralocorticoid receptor to the nucleus. J Biol Chem. 2005;280:17549-61 pubmed
    The mineralocorticoid receptor (MR) is a tightly regulated nuclear hormone receptor that selectively transmits corticosteroid signals...
  61. Li R, Xie M, Lv J, Wai Chi Chan E, Chen S. Complete genetic analysis of plasmids carrying mcr-1 and other resistance genes in an Escherichia coli isolate of animal origin. J Antimicrob Chemother. 2017;72:696-699 pubmed publisher
    To investigate the genetic features of three plasmids recovered from an MCR-1 and ESBL-producing Escherichia coli strain, HYEC7, and characterize the transmission mechanism of mcr-1 .
  62. Navarro Reig M, Jaumot J, Pina B, Moyano E, Galceran M, Tauler R. Metabolomic analysis of the effects of cadmium and copper treatment in Oryza sativa L. using untargeted liquid chromatography coupled to high resolution mass spectrometry and all-ion fragmentation. Metallomics. 2017;9:660-675 pubmed publisher analysis strategy is based on the application of the multivariate curve resolution alternating least squares (MCR-ALS) method for feature detection, allowing the simultaneous resolution of pure chromatographic profiles and mass ..
  63. Serafini M, Griglio A, Viarengo S, Aprile S, Pirali T. An aryne-based three-component access to ?-aroylamino amides. Org Biomol Chem. 2017;15:6604-6612 pubmed publisher
    ..Finally, the synthetic utility of the reported MCR was exemplified by the preparation of proglumide, a cholecystokinin antagonist.
  64. Kurtzer I, Bouyer L, Bouffard J, Jin A, Christiansen L, Nielsen J, et al. Variable impact of tizanidine on the medium latency reflex of upper and lower limbs. Exp Brain Res. 2018;236:665-677 pubmed publisher
    ..Following the short-latency reflex and preceding voluntary reactions is an epoch termed the medium-latency reflex (MLR) that could reflect spinal processing of group II muscle afferents...
  65. Bledsoe R, Madauss K, Holt J, Apolito C, Lambert M, Pearce K, et al. A ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptor. J Biol Chem. 2005;280:31283-93 pubmed
    Ligand binding is the first step in hormone regulation of mineralocorticoid receptor (MR) activity. Here, we report multiple crystal structures of MR (NR3C2) bound to both agonist and antagonists...
  66. Zhang Q, Wang H, Wang Y, Yang M, Zhu L. Groundwater quality assessment and pollution source apportionment in an intensely exploited region of northern China. Environ Sci Pollut Res Int. 2017;24:16639-16650 pubmed publisher
    ..Using PCA and absolute principal component scores-multivariate linear regression (APCS-MLR), results show that domestic wastewater and agricultural runoff are the main sources of groundwater pollution in ..
  67. Benvidi A, Rezaeinasab M, Gharaghani S, Abbasi S. Monitoring the protective ability of thymoquinone mixture with p-cymene against bovine serum albumin (BSA) glycation: MCR-ALS analysis based on combined spectroscopic and electrochemical methods. Int J Biol Macromol. 2018;107:2465-2474 pubmed publisher
    ..Also, the multivariate curve resolution-alternating least squares (MCR-ALS) method was used since the results of the experimental measurements have a strongly overlapping signals...
  68. Arriza J, Weinberger C, Cerelli G, Glaser T, Handelin B, Housman D, et al. Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science. 1987;237:268-75 pubmed activate gene transcription in response to aldosterone, thus establishing its identity as the human mineralocorticoid receptor (hMR)...
  69. Luo J, Yao X, Lv L, Doi Y, Huang X, Huang S, et al. Emergence of mcr-1 in Raoultella ornithinolytica and Escherichia coli Isolates from Retail Vegetables in China. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    The presence of mcr-1 among Enterobacteriaceae isolates collected from retail vegetables in China between 2015 and 2016 was investigated...
  70. Schwarz S, Johnson A. Transferable resistance to colistin: a new but old threat. J Antimicrob Chemother. 2016;71:2066-70 pubmed publisher
    ..summarize current knowledge of the occurrence of the first and so far only transferable colistin resistance gene, mcr-1 Its location on a conjugative plasmid is likely to have driven its spread into a range of enteric bacteria in ..
  71. Hamid N, Syed J, Junaid M, Mahmood A, Li J, Zhang G, et al. Elucidating the urban levels, sources and health risks of polycyclic aromatic hydrocarbons (PAHs) in Pakistan: Implications for changing energy demand. Sci Total Environ. 2018;619-620:165-175 pubmed publisher
    ..0ngg-1). Further, the source apportionment PCA-MLR receptor model identified diesel and gasoline combustion as the primary PAHs sources in the urban and sub-urban ..
  72. Dos Santos D, Deobald A, Cornelio V, Ávila R, Cornea R, Bernasconi G, et al. Asymmetric synthesis and evaluation of epoxy-?-acyloxycarboxamides as selective inhibitors of cathepsin L. Bioorg Med Chem. 2017;25:4620-4627 pubmed publisher
    ..This class of compounds is straightforward obtained by using a green one-pot asymmetric epoxidation/Passerini 3-MCR. A small library of 17 compounds was evaluated against cathepsin L, and among them LSPN423 showed to be the most ..
  73. Felder R. Mineralocorticoid receptors, inflammation and sympathetic drive in a rat model of systolic heart failure. Exp Physiol. 2010;95:19-25 pubmed publisher
    ..Other potential downstream signalling mechanisms contributing to mineralocorticoid receptor-mediated sympathetic excitation are under investigation.
  74. Matić G, Vojnović Milutinović D, Nestorov J, Elaković I, Manitašević Jovanović S, Elzaedi Y, et al. Mineralocorticoid receptor and heat shock protein expression levels in peripheral lymphocytes from war trauma-exposed men with and without PTSD. Psychiatry Res. 2014;215:379-85 pubmed publisher
    ..In conclusion, PTSD and exposure to trauma are not related to changes in lymphocyte MR, Hsp90 or Hsp70 levels, but may be associated with disturbances in corticosteroid receptors interaction with heat shock proteins. ..
  75. Mohan T, Bahulayan D. Design, synthesis and fluorescence property evaluation of blue emitting triazole-linked chromene peptidomimetics. Mol Divers. 2017;21:585-596 pubmed publisher
    A highly efficient "Click with MCR" strategy for the three-step synthesis of two types of blue emitting chromene peptidomimetics is described...
  76. Mehus A, Picklo M. Brain and Hepatic Mt mRNA Is Reduced in Response to Mild Energy Restriction and n-3 Polyunsaturated Fatty Acid Deficiency in Juvenile Rats. Nutrients. 2017;9: pubmed publisher
    ..of MTs (Mt1-3) and modulators of MT expression including glucocorticoid receptors (Nr3c1 and Nr3c2) and several mediators of thyroid hormone regulation (Dio1-3, Mct8, Oatp1c1, Thra, ..
  77. Gomez Sanchez E, Gomez Sanchez C. Central regulation of blood pressure by the mineralocorticoid receptor. Mol Cell Endocrinol. 2012;350:289-98 pubmed publisher
    Addition of mineralocorticoid receptor (MR) antagonists to standard therapy for heart failure, kidney disease, metabolic syndrome, and diabetes is increasing steadily in response to clinical trials demonstrating clear benefits...
  78. Mikkelsen E, Mariager C, Nørlinger T, Qi H, Schulte R, Jakobsen S, et al. Hyperpolarized [1-13C]-acetate Renal Metabolic Clearance Rate Mapping. Sci Rep. 2017;7:16002 pubmed publisher
    ..The metabolic clearance rates (MCR) were estimated and compared between the two modalities experimentally in vivo and in simulations...
  79. Navarro M. The Role of the Melanocortin System in Drug and Alcohol Abuse. Int Rev Neurobiol. 2017;136:121-150 pubmed publisher
    ..MC3R and MC4R are the predominant MCR subtypes in the brain, and they are widely expressed in brain regions thought to modulate drug self-administration, ..
  80. Al Majali I, Al Oran S, Hassuneh M, Al Qaralleh H, Rayyan W, Al Thunibat O, et al. Immunomodulatory effect of Moringa peregrina leaves, ex vivo and in vivo study. Cent Eur J Immunol. 2017;42:231-238 pubmed publisher
    ..capacity of splenic lymphocytes and peripheral T and B lymphocytes using mitogen blastogenesis, mixed allogeneic MLR and IgM-Plaque forming cells assays. The ingestion of M...
  81. Lee H, Song M, Seok Y, Kang S, Kim S, Kim I. Histone Deacetylase 3 and 4 Complex Stimulates the Transcriptional Activity of the Mineralocorticoid Receptor. PLoS ONE. 2015;10:e0136801 pubmed publisher
    ..We previously reported that HDAC3 acts as a coactivator of the mineralocorticoid receptor (MR)...
  82. Juhász E, Iván M, Pintér E, Pongrácz J, Kristóf K. Colistin resistance among blood culture isolates at a tertiary care centre in Hungary. J Glob Antimicrob Resist. 2017;11:167-170 pubmed publisher
    ..Screening for mcr-1-mediated colistin resistance was performed by PCR. The rate of colistin resistance was 0.6%, 1.3% and 2...
  83. Vogel S, Gerritsen L, van Oostrom I, Arias Vasquez A, Rijpkema M, Joels M, et al. Linking genetic variants of the mineralocorticoid receptor and negative memory bias: interaction with prior life adversity. Psychoneuroendocrinology. 2014;40:181-90 pubmed publisher
    ..As variations in the mineralocorticoid receptor gene (NR3C2) have been related to a higher risk for depression, we investigated whether NR3C2 variance ..
  84. Li Z, Lu H, Gu J, Liu J, Zhu Q, Lu Y, et al. Chitinase 3-Like-1-Deficient Splenocytes Deteriorated the Pathogenesis of Acute Graft-Versus-Host Disease via Regulating Differentiation of Tfh Cells. Inflammation. 2017;40:1576-1588 pubmed publisher
    ..In this study, mixed lymphocyte reactions (MLR) in vitro showed that CHI3L1 deficiency in CD4+ T cell promoted the production of interferon (IFN)-? and ..
  85. Poch E, Gonzalez D, Giner V, Bragulat E, Coca A, de la Sierra A. Molecular basis of salt sensitivity in human hypertension. Evaluation of renin-angiotensin-aldosterone system gene polymorphisms. Hypertension. 2001;38:1204-9 pubmed
    ..type 2 (11betaHSD2) (G534A), aldosterone synthase (C-344T and Intron 2 conversion), and the mineralocorticoid receptor (G3514C and A4582C); all were determined using standard polymerase chain reaction methods...
  86. Sainte Marie Y, Toulon A, Paus R, Maubec E, Cherfa A, Grossin M, et al. Targeted skin overexpression of the mineralocorticoid receptor in mice causes epidermal atrophy, premature skin barrier formation, eye abnormalities, and alopecia. Am J Pathol. 2007;171:846-60 pubmed
    The mineralocorticoid receptor (MR) is a transcription factor of the nuclear receptor family, activation of which by aldosterone enhances salt reabsorption in the kidney...
  87. Grossmann C, Freudinger R, Mildenberger S, Husse B, Gekle M. EF domains are sufficient for nongenomic mineralocorticoid receptor actions. J Biol Chem. 2008;283:7109-16 pubmed publisher
    The mineralocorticoid receptor (MR) is important for salt homeostasis and reno-cardiovascular pathophysiology...
  88. Caltagirone M, Nucleo E, Spalla M, Zara F, Novazzi F, Marchetti V, et al. Occurrence of Extended Spectrum ?-Lactamases, KPC-Type, and MCR-1.2-Producing Enterobacteriaceae from Wells, River Water, and Wastewater Treatment Plants in Oltrepò Pavese Area, Northern Italy. Front Microbiol. 2017;8:2232 pubmed publisher
    ..were also characterized for the Extended-Spectrum-?-Lactamases (ESBLs), carbapenemases, and mcr-1 genes presence...
  89. Li R, Yu H, Xie M, Chen K, Dong N, Lin D, et al. Genetic basis of chromosomally-encoded mcr-1 gene. Int J Antimicrob Agents. 2018;51:578-585 pubmed publisher
    Compared with plasmid-borne mcr-1, the occurrence of chromosomally-encoded mcr-1 is rare although it has been reported in several cases...
  90. Kortmann G, Contini V, Bertuzzi G, Mota N, Rovaris D, Paixão Côrtes V, et al. The role of a mineralocorticoid receptor gene functional polymorphism in the symptom dimensions of persistent ADHD. Eur Arch Psychiatry Clin Neurosci. 2013;263:181-8 pubmed publisher
    ..The mineralocorticoid receptor is the main receptor involved in the initial triggering of stress response...
  91. Leopold J. Aldosterone, mineralocorticoid receptor activation, and cardiovascular remodeling. Circulation. 2011;124:e466-8 pubmed publisher
  92. Liu X, Li R, Zheng Z, Chen K, Xie M, Chan E, et al. Molecular Characterization of Escherichia coli Isolates Carrying mcr-1, fosA3, and Extended-Spectrum-β-Lactamase Genes from Food Samples in China. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    This study surveyed the prevalence of mcr-1 in extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli strains of food origin in China and identified strains that carried mcr-1, fosA3, and ESBL ..