Gene Symbol: NR2F2
Description: nuclear receptor subfamily 2 group F member 2
Alias: ARP1, CHTD4, COUPTF2, COUPTFB, COUPTFII, NF-E3, NR2F1, SVP40, TFCOUP2, COUP transcription factor 2, ADP-ribosylation factor related protein 1, COUP transcription factor II, apolipoprotein A-I regulatory protein 1, apolipoprotein AI regulatory protein 1, chicken ovalbumin upstream promoter transcription factor 2, chicken ovalbumin upstream promoter-transcription factor I
Species: human
Products:     NR2F2

Top Publications

  1. Ladias J, Karathanasis S. Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily. Science. 1991;251:561-5 pubmed
    ..In cotransfection experiments, ARP-1 downregulated the apoAI gene. The involvement of ARP-1 in the regulation of apoAI gene expression suggests that it may participate in lipid metabolism and cholesterol homeostasis. ..
  2. Avram D, Fields A, Pretty On Top K, Nevrivy D, Ishmael J, Leid M. Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. J Biol Chem. 2000;275:10315-22 pubmed
    ..The interaction of CTIP1 with ARP1 was studied in detail, and CTIP1 was found to harbor two independent ARP1 interaction domains, ID1 and ID2, whereas ..
  3. Reinchisi G, Ijichi K, Glidden N, Jakovcevski I, Zecevic N. COUP-TFII expressing interneurons in human fetal forebrain. Cereb Cortex. 2012;22:2820-30 pubmed publisher
    ..The source of these cells seems to be the CGE and, to a smaller extent, the cortical VZ/SVZ. ..
  4. Qiu Y, Krishnan V, Zeng Z, Gilbert D, Copeland N, Gibson L, et al. Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes. Genomics. 1995;29:240-6 pubmed
    ..Furthermore, we mapped human COUP-TF I to 5q14 of chromosome 5 and COUP-TF II to 15q26 of chromosome 15. The results demonstrate that COUP-TF genes are located in chromosomal regions that are syntenic between mouse and human. ..
  5. Marcus S, Winrow C, Capone J, Rachubinski R. A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor. J Biol Chem. 1996;271:27197-200 pubmed
    ..This factor is identical to a recently described ligand of the tyrosine kinase signaling molecule p56(lck), suggesting that it mediates cross-talk between mitogenic and nuclear hormone receptor signal transduction pathways. ..
  6. Avram D, Ishmael J, Nevrivy D, Peterson V, Lee S, Dowell P, et al. Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2. J Biol Chem. 1999;274:14331-6 pubmed
    ..factor (COUP-TF) subfamily of orphan nuclear receptors, which minimally includes COUP-TFI and ARP1, are highly expressed in brain and are generally considered to be constitutive repressors of transcription...
  7. Liberati C, Cera M, Secco P, Santoro C, Mantovani R, Ottolenghi S, et al. Cooperation and competition between the binding of COUP-TFII and NF-Y on human epsilon- and gamma-globin gene promoters. J Biol Chem. 2001;276:41700-9 pubmed
    ..At the 5' site, COUP-TFII might cooperate with NF-Y, forming a stable complex, and stimulate transcription; at the 3' site, COUP-TFII might compete for binding with NF-Y and, directly or indirectly, decrease gene activity. ..
  8. De Martino M, Bhattachryya N, Alesci S, Ichijo T, Chrousos G, Kino T. The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II interact with and mutually affect each other's transcriptional activities: implications for intermediary metabolism. Mol Endocrinol. 2004;18:820-33 pubmed
    ..These interactions influence the transcription of both COUP-TFII- and GRalpha-responsive target genes, seem to be promoter specific, and can be in either a positive or negative direction. ..
  9. De Martino M, Alesci S, Chrousos G, Kino T. Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism. Ann N Y Acad Sci. 2004;1024:72-85 pubmed
    ..It appears that glucocorticoids exert their intermediary effects partly via physical interaction with COUP-TFII. ..

More Information

Publications125 found, 100 shown here

  1. Shibata H, Kobayashi S, Kurihara I, Suda N, Yokota K, Murai A, et al. COUP-TF and transcriptional co-regulators in adrenal steroidogenesis. Endocr Res. 2004;30:795-801 pubmed
    ..These findings indicate that Ubc9 and PIAS1 can function as transcriptional co-regulators of COUP-TFI to modulate adrenal cortical steroidogenesis in a SUMOylation-independent manner. ..
  2. Kruse S, Suino Powell K, Zhou X, Kretschman J, Reynolds R, Vonrhein C, et al. Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor. PLoS Biol. 2008;6:e227 pubmed publisher
  3. Leisegang M, Fork C, Josipovic I, Richter F, Preussner J, Hu J, et al. Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function. Circulation. 2017;136:65-79 pubmed publisher
    ..MANTIS is a differentially regulated novel lncRNA facilitating endothelial angiogenic function. ..
  4. Yang X, Feng S, Tang K. COUP-TF Genes, Human Diseases, and the Development of the Central Nervous System in Murine Models. Curr Top Dev Biol. 2017;125:275-301 pubmed publisher
    ..Clearly, the investigations on the functions of COUP-TF genes in the developing mouse central nervous system will benefit not only the understanding of neurodevelopment, but also the etiology of human mental diseases. ..
  5. Lacey M, Baribault C, Ehrlich K, Ehrlich M. Atherosclerosis-associated differentially methylated regions can reflect the disease phenotype and are often at enhancers. Atherosclerosis. 2019;280:183-191 pubmed publisher
    ..developmental transcription factor genes having little or no previous association with atherosclerosis, such as NR2F2 (COUP-TFII) and TBX18...
  6. Qin X, Tatsukawa H, Hitomi K, Shirakami Y, Ishibashi N, Shimizu M, et al. Metabolome Analyses Uncovered a Novel Inhibitory Effect of Acyclic Retinoid on Aberrant Lipogenesis in a Mouse Diethylnitrosamine-Induced Hepatic Tumorigenesis Model. Cancer Prev Res (Phila). 2016;9:205-14 pubmed publisher
    ..analysis identified that a key transcription regulator of both embryogenesis and tumorigenesis, COUP transcription factor 2, also known as NR2F2, was associated with the metabolic effect of ACR in human hepatocellular carcinoma ..
  7. Pursani V, Bhartiya D, Tanavde V, Bashir M, Sampath P. Transcriptional activator DOT1L putatively regulates human embryonic stem cell differentiation into the cardiac lineage. Stem Cell Res Ther. 2018;9:97 pubmed publisher
    ..This included genes like MYOF, NR2F2, NKX2.5, and HAND1 in cardiac progenitors and cardiomyocytes, and POU5F1 and NANOG in pluripotent hES cells...
  8. Guo J, Ito S, Nguyen H, Yamamoto K, Tanoue R, Kunisue T, et al. Effects of prenatal exposure to triclosan on the liver transcriptome in chicken embryos. Toxicol Appl Pharmacol. 2018;347:23-32 pubmed publisher
    ..Finally, we developed adverse outcome pathways (AOPs) that provide insights into the molecular mechanisms underlying the alteration of phenotypes. ..
  9. Wang J, Hua L, Chen J, Zhang J, Bai X, Gao B, et al. Identification and characterization of long non-coding RNAs in subcutaneous adipose tissue from castrated and intact full-sib pair Huainan male pigs. BMC Genomics. 2017;18:542 pubmed publisher
    ..and found it mainly expressed in the cell nucleus and target the Nuclear Receptor Subfamily 2 Group F Member 2 (NR2F2) gene...
  10. Pawar S, Laws M, Bagchi I, Bagchi M. Uterine Epithelial Estrogen Receptor-α Controls Decidualization via a Paracrine Mechanism. Mol Endocrinol. 2015;29:1362-74 pubmed publisher
    ..Collectively our results provide unique insights into the paracrine mechanisms by which ESR1 directs epithelial-stromal dialogue during pregnancy establishment. ..
  11. Valiante V, Baldin C, Hortschansky P, Jain R, Thywißen A, Straßburger M, et al. The Aspergillus fumigatus conidial melanin production is regulated by the bifunctional bHLH DevR and MADS-box RlmA transcription factors. Mol Microbiol. 2016;102:321-335 pubmed publisher
    ..cross-species promoter analysis identified specific DNA binding sites in the DHN-melanin biosynthesis genes pksP-arp1 intergenic region that can be recognized by bHLH and MADS-box transcriptional regulators...
  12. Vasquez Y, Wu S, Anderson M, Hawkins S, Creighton C, Ray M, et al. Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis. Mol Endocrinol. 2016;30:518-32 pubmed publisher
  13. Zhang R, Wang Y, Li R, Chen G. Transcriptional Factors Mediating Retinoic Acid Signals in the Control of Energy Metabolism. Int J Mol Sci. 2015;16:14210-44 pubmed publisher
    ..Herein, we summarize current progresses regarding the VA metabolism and the role of nuclear receptors in mediating RA signals, with an emphasis on their implication in energy metabolism. ..
  14. Lyu G, Zhang C, Ling T, Liu R, Zong L, Guan Y, et al. Genome and epigenome analysis of monozygotic twins discordant for congenital heart disease. BMC Genomics. 2018;19:428 pubmed publisher
    ..Particularly, ZIC3 and NR2F2 are found to have hypermethylated promoters in both the diseased twin and additional patients suffering from DORV...
  15. Argenziano M, Lambers E, Hong L, Sridhar A, Zhang M, Chalazan B, et al. Electrophysiologic Characterization of Calcium Handling in Human Induced Pluripotent Stem Cell-Derived Atrial Cardiomyocytes. Stem Cell Reports. 2018;10:1867-1878 pubmed publisher
    ..Collectively, our results provide important insights into the underlying molecular mechanisms that regulate atrial-like hiPSC-CM electrophysiology and support the use of atrial-like CMs derived from hiPSCs to model AF. ..
  16. Aumeier C, Polinski E, Menzel D. Actin, actin-related proteins and profilin in diatoms: a comparative genomic analysis. Mar Genomics. 2015;23:133-42 pubmed publisher
    ..Among these are the highly conserved cytoplasmic Arp1 protein and the nuclear Arp4 as well as Arp6...
  17. Delépine C, Nectoux J, Letourneur F, Baud V, Chelly J, Billuart P, et al. Astrocyte Transcriptome from the Mecp2(308)-Truncated Mouse Model of Rett Syndrome. Neuromolecular Med. 2015;17:353-63 pubmed publisher
    ..Moreover, transcriptional profiling revealed altered Nr2f2 expression which may explain down- and upregulation of several target genes in astrocytes such as Ccl2, Lcn2 and ..
  18. Hwa J, Beckouche N, Huang L, Kram Y, Lindskog H, Wang R. Abnormal arterial-venous fusions and fate specification in mouse embryos lacking blood flow. Sci Rep. 2017;7:11965 pubmed publisher
    ..We propose a molecular mechanism by which blood flow mediates DA and CV morphogenesis, by regulating arterial-venous specification of DA ECs to ensure proper separation of the developing DA and CV. ..
  19. Garattini E, Bolis M, Gianni M, Paroni G, Fratelli M, Terao M. Lipid-sensors, enigmatic-orphan and orphan nuclear receptors as therapeutic targets in breast-cancer. Oncotarget. 2016;7:42661-42682 pubmed publisher
    ..The Enigmatic-Orphans, NR1F1 NR2A1 and NR3B3 as well as the Orphan-Receptors, NR0B1, NR0B2, NR1D1, NR2F1, NR2F2 and NR4A3 exert a similar action...
  20. Guo J, Ito S, Nguyen H, Yamamoto K, Iwata H. Effects on the hepatic transcriptome of chicken embryos in ovo exposed to phenobarbital. Ecotoxicol Environ Saf. 2018;160:94-103 pubmed publisher
    ..Taken together, our results provided an insight into the mode of action of PB on the chicken embryos. ..
  21. Kardon G, Ackerman K, McCulley D, Shen Y, Wynn J, Shang L, et al. Congenital diaphragmatic hernias: from genes to mechanisms to therapies. Dis Model Mech. 2017;10:955-970 pubmed publisher
    ..affected genes identified in CDH patients include transcription factors, such as GATA4, ZFPM2, NR2F2 and WT1, and signaling pathway components, including members of the retinoic acid pathway...
  22. Nieuwburg R, Nashchekin D, Jakobs M, Carter A, Khuc Trong P, Goldstein R, et al. Localised dynactin protects growing microtubules to deliver oskar mRNA to the posterior cortex of the Drosophila oocyte. elife. 2017;6: pubmed publisher
    ..A missense mutation in the dynactin Arp1 subunit causes most oskar mRNA to localise in the posterior cytoplasm rather than cortically...
  23. Oh S, Shin J, Kim T, Lee H, Yoo J, Ahn J, et al. ?-Catenin activation contributes to the pathogenesis of adenomyosis through epithelial-mesenchymal transition. J Pathol. 2013;231:210-22 pubmed publisher
    ..These results suggest that abnormal activation of ?-catenin contributes to adenomyosis development through the induction of EMT. ..
  24. Su T, Stanley G, Sinha R, D Amato G, Das S, Rhee S, et al. Single-cell analysis of early progenitor cells that build coronary arteries. Nature. 2018;559:356-362 pubmed publisher
    ..The vein-specifying transcription factor COUP-TF2 (also known as NR2F2) prevented plexus cells from overcoming the pre-artery threshold by inducing cell cycle genes...
  25. Nosavanh L, Yu D, Jaehnig E, Tong Q, Shen L, Chen M. Cell-autonomous activation of Hedgehog signaling inhibits brown adipose tissue development. Proc Natl Acad Sci U S A. 2015;112:5069-74 pubmed publisher
    ..Taken together, our studies uncover a previously unidentified role for Hh as an inhibitor of BAT development. ..
  26. Chiang M, Kuo C, Wang W, Hou T, Kuo C, Lu M, et al. Correlations between Histological and Array Comparative Genomic Hybridization Characterizations of Wilms Tumor. Pathol Oncol Res. 2019;: pubmed publisher
    ..Amplifications of NDUFV1, ZIC2, SIX1, NR2F2, MIR1469, SOX9, JAG1, MIR6870, and GNAS were found in all six Wilms tumors...
  27. Churko J, Garg P, Treutlein B, Venkatasubramanian M, Wu H, Lee J, et al. Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis. Nat Commun. 2018;9:4906 pubmed publisher
    ..with each cell population, we systematically tested the effect of a gain or loss of three transcription factors (NR2F2, TBX5, and HEY2), using CRISPR genome editing and ChIP-seq, in conjunction with patch clamp, calcium imaging, and ..
  28. Tan I, Wojcinski A, Rallapalli H, Lao Z, Sanghrajka R, Stephen D, et al. Lateral cerebellum is preferentially sensitive to high sonic hedgehog signaling and medulloblastoma formation. Proc Natl Acad Sci U S A. 2018;115:3392-3397 pubmed publisher
    ..GCP gene-expression profiles, and found that deletion of the genes most highly expressed in the hemispheres (Nr2f2) or vermis (Engrailed1) showed opposing effects on GCP differentiation...
  29. Urnavicius L, Zhang K, Diamant A, Motz C, Schlager M, Yu M, et al. The structure of the dynactin complex and its interaction with dynein. Science. 2015;347:1441-1446 pubmed publisher
    ..reconstruction reveals how dynactin is built around a filament containing eight copies of the actin-related protein Arp1 and one of β-actin...
  30. Hu J, Vogt D, Lindtner S, Sandberg M, Silberberg S, Rubenstein J. Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons. Development. 2017;144:2837-2851 pubmed publisher
    ..We provide evidence that Coup-TF1 and Coup-TF2 (Nr2f1 and Nr2f2) transcription factor expression in an arc-shaped progenitor domain within the MGE promotes ..
  31. Campbell R, Walthall W. Meis/UNC-62 isoform dependent regulation of CoupTF-II/UNC-55 and GABAergic motor neuron subtype differentiation. Dev Biol. 2016;419:250-261 pubmed publisher
    ..Isoform specific regulation of differentiating neurons is a relatively unexplored area of research and presents a mechanism for creating differences among functionally related cells within a network. ..
  32. Jeong B, Kang I, Hwang Y, Kim S, Koh J. MicroRNA-194 reciprocally stimulates osteogenesis and inhibits adipogenesis via regulating COUP-TFII expression. Cell Death Dis. 2014;5:e1532 pubmed publisher
    ..This suggests that miR-194 and COUP-TFII may be good target molecules for controlling bone and metabolic diseases. ..
  33. Fujita I, Yamashita A, Yamamoto M. Dynactin and Num1 cooperate to establish the cortical anchoring of cytoplasmic dynein in S. pombe. J Cell Sci. 2015;128:1555-67 pubmed publisher
    ..Here, we identified three subunits of dynactin in fission yeast: Arp1, Mug5 and Jnm1 (also known as Mug1)...
  34. Joo H, Song S, Seo H, Shin J, Choi S, Park J, et al. Human endothelial colony forming cells from adult peripheral blood have enhanced sprouting angiogenic potential through up-regulating VEGFR2 signaling. Int J Cardiol. 2015;197:33-43 pubmed publisher
    ..ECFCs derived from adult peripheral blood had enhanced sprouting angiogenic potential in vitro and in vivo through up-regulation of the VEGFR2 signaling pathway. ..
  35. Kim J, Kim D, Yu M, Cha M, Yu S, Kang J. Role of epigenetics in the pathogenesis of chronic rhinosinusitis with nasal polyps. Mol Med Rep. 2017;: pubmed publisher
    ..altered hypomethylation in NP tissues were, Keratin 19 (KRT19), nuclear receptor subfamily 2 group F member 2 (NR2F2), A Disintegrin?like And Metallopeptidase (Reprolysin Type) with Thrombospondin type 1 motif 1 (ADAMTS1) and zinc ..
  36. Maffey L, Vega C, Parreño V, Garaicoechea L. Controlling Rotavirus-associated diarrhea: Could single-domain antibody fragments make the difference?. Rev Argent Microbiol. 2015;47:368-79 pubmed publisher
    ..Two sets of anti-RVA VHHs have been developed: ARP1-ARP3; 2KD1-3B2...
  37. Zhu N, Wang H, Wang B, Wei J, Shan W, Feng J, et al. A Member of the Nuclear Receptor Superfamily, Designated as NR2F2, Supports the Self-Renewal Capacity and Pluripotency of Human Bone Marrow-Derived Mesenchymal Stem Cells. Stem Cells Int. 2016;2016:5687589 pubmed publisher
    Mesenchymal stem cells are characterized with self-renewal capacity and pluripotency. NR2F2 is a nuclear receptor that has been detected in the mesenchymal compartment of developing organs...
  38. Bailey P, Sartorelli V, Hamamori Y, Muscat G. The orphan nuclear receptor, COUP-TF II, inhibits myogenesis by post-transcriptional regulation of MyoD function: COUP-TF II directly interacts with p300 and myoD. Nucleic Acids Res. 1998;26:5501-10 pubmed
  39. Varga C, Tamas G, Barzo P, Oláh S, Somogyi P. Molecular and Electrophysiological Characterization of GABAergic Interneurons Expressing the Transcription Factor COUP-TFII in the Adult Human Temporal Cortex. Cereb Cortex. 2015;25:4430-49 pubmed publisher
    ..In conclusion, COUP-TFII is expressed in a diverse subset of GABAergic interneurons predominantly innervating small dendritic shafts originating from both interneurons and pyramidal cells. ..
  40. Mietus Snyder M, Sladek F, Ginsburg G, Kuo C, Ladias J, Darnell J, et al. Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells. Mol Cell Biol. 1992;12:1708-18 pubmed
    ..of the steroid receptor superfamily of transcription factors, hepatocyte nuclear factor 4 (HNF-4), apolipoprotein AI regulatory protein 1 (ARP-1), and Ear3/COUP-TF, act at the C3P site...
  41. Hubert M, Sherritt S, Bachurski C, Handwerger S. Involvement of transcription factor NR2F2 in human trophoblast differentiation. PLoS ONE. 2010;5:e9417 pubmed publisher
    ..cytotrophoblast (CTB) cells to a syncytiotrophoblast (STB) phenotype, mRNA levels for the nuclear hormone receptor NR2F2 (ARP-1, COUP-TFII) increase rapidly, reaching a peak at day 1 of differentiation that is 8...
  42. Larsen Z, Chander P, Joyner J, Floruta C, Demeter T, Weick J. Effects of Ethanol on Cellular Composition and Network Excitability of Human Pluripotent Stem Cell-Derived Neurons. Alcohol Clin Exp Res. 2016;40:2339-2350 pubmed publisher
    ..g., GSX2, DLX1/2/5/6, NR2F2) as well as mature IN specification (e.g., SST, NPY)...
  43. Boutant M, Ramos O, Tourrel Cuzin C, Movassat J, Ilias A, Vallois D, et al. COUP-TFII controls mouse pancreatic β-cell mass through GLP-1-β-catenin signaling pathways. PLoS ONE. 2012;7:e30847 pubmed publisher
    ..COUP-TFII is required for GLP-1 activation of the β-catenin-dependent pathway and its expression is under the control of TCF7L2. ..
  44. Lehoux S, Jones E. Shear stress, arterial identity and atherosclerosis. Thromb Haemost. 2016;115:467-73 pubmed publisher
  45. Lee M, Kim J, Oh S, Jeong B, Hwang Y, Koh J. FGF2 Stimulates COUP-TFII Expression via the MEK1/2 Pathway to Inhibit Osteoblast Differentiation in C3H10T1/2 Cells. PLoS ONE. 2016;11:e0159234 pubmed publisher
  46. Teratani Ota Y, Yamamizu K, Piao Y, Sharova L, Amano M, Yu H, et al. Induction of specific neuron types by overexpression of single transcription factors. In Vitro Cell Dev Biol Anim. 2016;52:961-973 pubmed
    ..The majority of neuron-like cells generated by induction of Ascl1, Smad7, Nr2f1, Dlx2, Dlx4, Nr2f2, Barhl2, and Lhx1 were GABA-positive and expressed other markers of GABAergic neurons...
  47. Molinari E, Bar H, Pyle A, Patrizio P. Transcriptome analysis of human cumulus cells reveals hypoxia as the main determinant of follicular senescence. Mol Hum Reprod. 2016;22:866-76 pubmed publisher
    ..o., genes involved in the hypoxia stress response (NOS2, RORA and NR4A3), vasculature development (NR2F2, PTHLH), glycolysis (RALGAPA2 and TBC1D4) and cAMP turnover (PDE4D) were significantly overexpressed when compared ..
  48. Zhou B, Song J, Han T, Huang M, Jiang H, Qiao H, et al. MiR-382 inhibits cell growth and invasion by targeting NR2F2 in colorectal cancer. Mol Carcinog. 2016;55:2260-2267 pubmed publisher
    ..However, the role of miR-382 in CRC has not been sufficiently investigated. NR2F2 (also known as COUP-TFII), a member of the steroid/thyroid receptor superfamily, is often aberrantly activated in ..
  49. Bringuier P, Schalken J, Hervieu V, Giroldi L. Involvement of orphan nuclear receptor COUP-TFII in cadherin-6 and cadherin-11 regulation: implications in development and cancer. Mech Dev. 2015;136:64-72 pubmed publisher
    ..Using transfection and RNA-interference we demonstrate that COUP-TFII (NR2F2) induces down-regulation of cadherin-6 and up-regulation of cadherin-11 in cultured cell lines...
  50. Wu S, Kao C, Wang L, Creighton C, Yang J, Donti T, et al. Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure. Nat Commun. 2015;6:8245 pubmed publisher
  51. Di Luoffo M, Brousseau C, Tremblay J. MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells. Andrology. 2016;4:335-44 pubmed publisher
    ..Recently, the transcription factors MEF2 and NR2F2 were identified in the mouse testis including in Leydig cells where they were found to regulate expression of ..
  52. Panaccione A, Chang M, Carbone B, Guo Y, Moskaluk C, Virk R, et al. NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem-Like Cells in Adenoid Cystic Carcinoma. Clin Cancer Res. 2016;22:2083-95 pubmed publisher
    ..activated NOTCH1 (N1ICD) and generated CD133(-)cells that expressed JAG1 as well as neural differentiation factors NR2F1, NR2F2, and p27Kip1...
  53. Bashamboo A, Eozenou C, Jorgensen A, Bignon Topalovic J, Siffroi J, Hyon C, et al. Loss of Function of the Nuclear Receptor NR2F2, Encoding COUP-TF2, Causes Testis Development and Cardiac Defects in 46,XX Children. Am J Hum Genet. 2018;102:487-493 pubmed publisher
    ..We identified heterozygous frameshift mutations in NR2F2, encoding COUP-TF2, in three children. One carried a c.103_109delGGCGCCC (p...
  54. Jones S, Boisvert A, Naghi A, Hullin Matsuda F, Greimel P, Kobayashi T, et al. Stimulatory effects of combined endocrine disruptors on MA-10 Leydig cell steroid production and lipid homeostasis. Toxicology. 2016;355-356:21-30 pubmed publisher
    ..steroidogenic and cholesterol mediators Star, Cyp11a, Srb1 and Hsl, as well as upstream orphan nuclear receptors Nr2f2 and Sf1 were all significantly increased uniquely in the mixture treatment group...
  55. Xie X, Tsai S, Tsai M. COUP-TFII regulates satellite cell function and muscular dystrophy. J Clin Invest. 2016;126:3929-3941 pubmed publisher
    ..Together, our findings reveal a regulatory role of COUP-TFII in the development of muscular dystrophy and open up a potential therapeutic opportunity for managing disease progression in patients with DMD. ..
  56. Chen H, Wang Y, Ge R, Zirkin B. Leydig cell stem cells: Identification, proliferation and differentiation. Mol Cell Endocrinol. 2017;445:65-73 pubmed publisher
    ..These studies, taken together, address the function and regulation of low turnover stem cells in a complex, adult organ, and also have potential application to the treatment of androgen deficiency. ..
  57. Chen Y, Huang H, Lin C. Regulatory feedback loops bridge the human gene regulatory network and regulate carcinogenesis. Brief Bioinform. 2017;: pubmed publisher
    ..More importantly, we identified one regulatory FBL between HNF4A and NR2F2 that possesses the highest bridgeness in the interface core...
  58. Li R, Wu T, Mou Y, Wang Y, Chen C, Wu C. Nr2f1b control venous specification and angiogenic patterning during zebrafish vascular development. J Biomed Sci. 2015;22:104 pubmed publisher
    ..The orphan nuclear receptor Chicken ovalbumin upstream promoter transcription factor II (CoupTFII, a.k.a NR2F2) positively regulates vein identity in mice...
  59. Yamazaki T, Suehiro J, Miyazaki H, Minami T, Kodama T, Miyazono K, et al. The COUP-TFII variant lacking a DNA-binding domain inhibits the activation of the Cyp7a1 promoter through physical interaction with COUP-TFII. Biochem J. 2013;452:345-57 pubmed publisher
    ..The results of the present study suggest that COUP-TFII-V2 negatively regulates the function of COUP-TFII by inhibiting its binding to DNA to decrease Cyp7a1 expression. ..
  60. Wu S, Yu C, Tsai S, Tsai M. Choose your destiny: Make a cell fate decision with COUP-TFII. J Steroid Biochem Mol Biol. 2016;157:7-12 pubmed publisher
    ..These novel insights pave the road for future studies of regenerative medicine. ..
  61. Lin S, Kao C, Lee H, Creighton C, Ittmann M, Tsai S, et al. Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer. Nat Commun. 2016;7:11418 pubmed publisher
    ..Taken together, our findings highlight the contribution of specific miRNAs through the regulation of the COUP-TFII-FOXM1-CENPF cascade in PCa metastasis and drug resistance. ..
  62. Jørgensen A, Nielsen J, Perlman S, Lundvall L, Mitchell R, Juul A, et al. Ex vivo culture of human fetal gonads: manipulation of meiosis signalling by retinoic acid treatment disrupts testis development. Hum Reprod. 2015;30:2351-63 pubmed publisher
    ..determining region Y)-box 9 (SOX9), anti-Müllerian hormone (AMH) (immature Sertoli cell markers), COUP transcription factor 2 (COUP-TFII) (marker of interstitial cells), forkhead box L2 (FOXL2) (granulosa cell marker), H2A ..
  63. Lim Y, Ngo H, Lee J, Son K, Park E, Hwang S. ADP-ribosylation Factor-related Protein 1 Interacts with NS5A and Regulates Hepatitis C Virus Propagation. Sci Rep. 2016;6:31211 pubmed publisher
    ..Silencing of ARFRP1 ablated relocalization of SNAP23 to LD. These data indicate that HCV regulates ARFRP1 for LD growth to facilitate viral propagation and thus ARFRP1 may be a potential target for antiviral therapy. ..
  64. Hawkins S, Loomans H, Wan Y, Ghosh Choudhury T, Coffey D, Xiao W, et al. Expression and functional pathway analysis of nuclear receptor NR2F2 in ovarian cancer. J Clin Endocrinol Metab. 2013;98:E1152-62 pubmed publisher
    Recent evidence implicates the orphan nuclear receptor, nuclear receptor subfamily 2, group F, member 2 (NR2F2; chicken ovalbumin upstream promoter-transcription factor II) as both a master regulator of angiogenesis and an oncogene in ..
  65. Feng S, Xing C, Shen T, Qiao Y, Wang R, Chen J, et al. Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII. Sci Rep. 2017;7:5282 pubmed publisher
  66. Li A, Hanchard N, Furthner D, Fernbach S, Azamian M, Nicosia A, et al. Whole exome sequencing in 342 congenital cardiac left sided lesion cases reveals extensive genetic heterogeneity and complex inheritance patterns. Genome Med. 2017;9:95 pubmed publisher
    ..including 9 confirmed de novo variants in both novel and newly described human CVM candidate genes (ACVR1, JARID2, NR2F2, PLRG1, SMURF1) as well as established syndromic CVM genes (KMT2D, NF1, TBX20, ZEB2)...
  67. Touzot A, Ruiz Reig N, Vitalis T, Studer M. Molecular control of two novel migratory paths for CGE-derived interneurons in the developing mouse brain. Development. 2016;143:1753-65 pubmed publisher
    ..Overall, we propose that the existence of spatially and temporally regulated migratory paths in the subpallium contributes to the laminar distribution and specification of distinct interneuron subpopulations in the adult brain...
  68. Johnson D, Li C, Chen L, Ghosh J, Chen J. Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT). Mol Pharmacol. 2006;69:99-108 pubmed
    ..Taken together, our results suggest that the corepressor SMRT may bind to and regulate the transcriptional activity of PXR. ..
  69. Kang J, Yoo J, Lee S, Tang W, Aguilar B, Ramu S, et al. An exquisite cross-control mechanism among endothelial cell fate regulators directs the plasticity and heterogeneity of lymphatic endothelial cells. Blood. 2010;116:140-50 pubmed publisher
    ..We propose that the expression of the 3 cell fate regulators is controlled by an exquisite feedback mechanism working in LECs and that LEC fate is a consequence of the Prox1-directed lymphatic equilibrium among the cell fate regulators. ..
  70. Chan C, Fulton J, Montiel Duarte C, Collins H, Bharti N, Wadelin F, et al. A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors. Nucleic Acids Res. 2013;41:9663-79 pubmed publisher
    ..Two copies of this motif (named here as RID1 and RID2) permit BCL11A to bind COUP-TFs (NR2F1;NR2F2;NR2F6) and Tailless/TLX (NR2E1), whereas RID1, but not RID2, binds PNR (NR2E3)...
  71. Li X, Large M, Creighton C, Lanz R, Jeong J, Young S, et al. COUP-TFII regulates human endometrial stromal genes involved in inflammation. Mol Endocrinol. 2013;27:2041-54 pubmed publisher
    Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII; NR2F2) is an orphan nuclear receptor involved in cell-fate specification, organogenesis, angiogenesis, and metabolism...
  72. Gao G, Zhang X, Hubbell K, Cui X. NR2F2 regulates chondrogenesis of human mesenchymal stem cells in bioprinted cartilage. Biotechnol Bioeng. 2017;114:208-216 pubmed publisher
    ..Here, we reported NR2F2 plays a crucial role in MSC chondrogenesis in bioprinted cartilage...
  73. Zhao F, Franco H, Rodriguez K, Brown P, Tsai M, Tsai S, et al. Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice. Science. 2017;357:717-720 pubmed publisher
    ..We thus suggest that elimination of Wolffian ducts in female embryos is actively promoted by COUP-TFII, which suppresses a mesenchyme-epithelium cross-talk responsible for Wolffian duct maintenance. ..
  74. Kurihara I, Shibata H, Kobayashi S, Suda N, Ikeda Y, Yokota K, et al. Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription. J Biol Chem. 2005;280:6721-30 pubmed
    ..Our data support a physiological role of Ubc9 and PIAS1 as transcriptional coactivators in COUP-TFI-mediated CYP11B2 transcription...
  75. Nagasaki S, Suzuki T, Miki Y, Akahira J, Shibata H, Ishida T, et al. Chicken ovalbumin upstream promoter transcription factor II in human breast carcinoma: possible regulator of lymphangiogenesis via vascular endothelial growth factor-C expression. Cancer Sci. 2009;100:639-45 pubmed publisher
    ..These results suggest that COUP-TFII is involved in the development of advanced human breast cancer. ..
  76. Boutant M, Ramos O, Lecoeur C, Vaillant E, Philippe J, Zhang P, et al. Glucose-dependent regulation of NR2F2 promoter and influence of SNP-rs3743462 on whole body insulin sensitivity. PLoS ONE. 2012;7:e35810 pubmed publisher
    The Nuclear Receptor 2F2 (NR2F2/COUP-TFII) heterozygous knockout mice display low basal insulinemia and enhanced insulin sensitivity. We previously established that insulin represses NR2F2 gene expression in pancreatic ?-cells...
  77. Qin J, Wu S, Creighton C, Dai F, Xie X, Cheng C, et al. COUP-TFII inhibits TGF-?-induced growth barrier to promote prostate tumorigenesis. Nature. 2013;493:236-40 pubmed publisher
    ..Here we show that COUP transcription factor II (COUP-TFII, also known as NR2F2), a member of the nuclear receptor superfamily, serves as a key ..
  78. Zheng J, Qin W, Jiao D, Ren J, Wei M, Shi S, et al. Knockdown of COUP-TFII inhibits cell proliferation and induces apoptosis through upregulating BRCA1 in renal cell carcinoma cells. Int J Cancer. 2016;139:1574-85 pubmed publisher
    ..These results indicate that COUP-TFII may play an oncogenic role in RCC, and COUP-TFII may promote tumor progression through inhibiting BRCA1. ..
  79. Zhang W, Liu J, Qiu J, Fu X, Tang Q, Yang F, et al. MicroRNA-382 inhibits prostate cancer cell proliferation and metastasis through targeting COUP-TFII. Oncol Rep. 2016;36:3707-3715 pubmed publisher
  80. Feng Q, Wu X, Li F, Ning B, Lu X, Zhang Y, et al. miR-27b inhibits gastric cancer metastasis by targeting NR2F2. Protein Cell. 2017;8:114-122 pubmed publisher
    Increasing attention is focused on the down-regulation of miRNAs in cancer process. Nuclear receptor subfamily 2 (NR2F2, also known as COUP-TFII) is involved in the development of many types of cancers, but its role in gastric cancer ..
  81. Kaiwar C, Zimmermann M, Ferber M, Niu Z, Urrutia R, Klee E, et al. Novel NR2F1 variants likely disrupt DNA binding: molecular modeling in two cases, review of published cases, genotype-phenotype correlation, and phenotypic expansion of the Bosch-Boonstra-Schaaf optic atrophy syndrome. Cold Spring Harb Mol Case Stud. 2017;3: pubmed publisher
    ..optic atrophy syndrome (BBSOAS) is a recently described autosomal dominant disorder caused by mutations in the NR2F1 gene. There are presently 28 cases of BBSOAS described in the literature...
  82. Ding W, Zhang Y, Cai H, Liu G, Ye Y, Xu G, et al. Overexpression of COUP?TFII suppresses proliferation and metastasis of human gastric cancer cells. Mol Med Rep. 2017;: pubmed publisher
    The abnormal expression of the chicken ovalbumin upstream promoter transcription factor 2 (COUP?TFII) is associated with numerous forms of cancer, including gastric, prostate, colon and lung cancer...
  83. Jordan E, Worley T, Breen G. Transcriptional regulation of the nuclear gene encoding the alpha-subunit of the mammalian mitochondrial F1F0 ATP synthase complex: role for the orphan nuclear receptor, COUP-TFII/ARP-1. Biochemistry. 2003;42:2656-63 pubmed
    ..Thus, the ATPA gene is regulated by a multifunctional binding site through which the transcription factors, COUP-TFII/ARP-1 and USF2, bind and exert their antagonistic effects. ..
  84. Yamazaki T, Yoshimatsu Y, Morishita Y, Miyazono K, Watabe T. COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction. Genes Cells. 2009;14:425-34 pubmed publisher
    ..These results suggest that COUP-TFII physically and functionally interact during differentiation and maintenance of lymphatic vessels. ..
  85. Iwagawa T, Tanaka Y, Iida A, Itoh T, Watanabe S. Enhancer/promoter activities of the long/middle wavelength-sensitive opsins of vertebrates mediated by thyroid hormone receptor ?2 and COUP-TFII. PLoS ONE. 2013;8:e72065 pubmed publisher
    ..In fact, immunostaining of common marmoset retinal sections revealed expression of COUP-TFII and red opsin in the cone cells. ..
  86. Smirnov D, Hou S, Ricciardi R. Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription. Virology. 2000;268:319-28 pubmed
    ..Taken together these results support the notion that deacetylation of histones, mediated through COUP-TF, serves to down-regulate MHC class I transcription in Ad12-transformed cells. ..
  87. Kurtev V, Margueron R, Kroboth K, Ogris E, Cavailles V, Seiser C. Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases. J Biol Chem. 2004;279:24834-43 pubmed
    ..We, therefore, propose a novel function for REA as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. ..
  88. Tang K, Xie X, Park J, Jamrich M, Tsai S, Tsai M. COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis. Development. 2010;137:725-34 pubmed publisher
    ..Here, we show that COUP-TFI (Nr2f1) and COUP-TFII (Nr2f2) are highly expressed in the progenitor cells in the developing murine eye...
  89. Krintel S, Palermo G, Johansen J, Germer S, Essioux L, Benayed R, et al. Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNF? inhibitors in patients with rheumatoid arthritis. Pharmacogenet Genomics. 2012;22:577-89 pubmed publisher
    ..A GSEA suggested that the transforming growth factor ?, TNF, mitogen-activated protein kinase, and mammalian target of rapamycin pathways may be associated with treatment response. ..
  90. Zhang C, Han Y, Huang H, Qu L, Shou C. High NR2F2 transcript level is associated with increased survival and its expression inhibits TGF-?-dependent epithelial-mesenchymal transition in breast cancer. Breast Cancer Res Treat. 2014;147:265-81 pubmed publisher
    b>NR2F2, a member of nuclear receptor subfamily 2, was shown to be associated with cancer, but its role in breast malignancy remains unclear. In this study, we aimed to explore the function of NR2F2 in breast cancer...
  91. Tornari C, Towers E, Gale J, Dawson S. Regulation of the orphan nuclear receptor Nr2f2 by the DFNA15 deafness gene Pou4f3. PLoS ONE. 2014;9:e112247 pubmed publisher
    ..The orphan thyroid nuclear receptor Nr2f2 was identified as a POU4F3 target using a subtractive hybridization strategy and EMSA analysis showed that POU4F3 ..
  92. Saraswat G, Guha R, Mondal K, Saha P, Banerjee S, Chakraborty P, et al. Molecular cues to the anti-implantation effect of nano-puerarin in rats. Reproduction. 2016;151:693-707 pubmed publisher
    ..PN also efficiently ablated the Ihh-Nr2f2-Bmp2 signalling pathway and invited the loss of uterine potential for decidualization...