Gene Symbol: NR2F1
Description: nuclear receptor subfamily 2 group F member 1
Alias: BBOAS, BBSOAS, COUP-TFI, COUPTF1, EAR-3, EAR3, ERBAL3, NR2F2, SVP44, TCFCOUP1, TFCOUP1, COUP transcription factor 1, COUP transcription factor I, COUP-TF I, COUP-TF1, V-erbA-related protein 3, chicken ovalbumin upstream promoter-transcription factor I, transcription factor COUP 1 (chicken ovalbumin upstream promoter 1, v-erb-a homolog-like 3)
Species: human
Products:     NR2F1

Top Publications

  1. Sawaya B, Rohr O, Aunis D, Schaeffer E. Chicken ovalbumin upstream promoter transcription factor, a transcriptional activator of HIV-1 gene expression in human brain cells. J Biol Chem. 1996;271:23572-6 pubmed
    ..These results reveal the importance of COUP-TF and the dopamine signaling pathway as activators of human immunodeficiency virus type 1 gene expression in brain. ..
  2. Rohr O, Aunis D, Schaeffer E. COUP-TF and Sp1 interact and cooperate in the transcriptional activation of the human immunodeficiency virus type 1 long terminal repeat in human microglial cells. J Biol Chem. 1997;272:31149-55 pubmed
    ..These findings reveal how the novel interplay of Sp1 and COUP-TF families of transcription factors regulate HIV-1 gene expression. ..
  3. Rohr O, Schwartz C, Hery C, Aunis D, Tardieu M, Schaeffer E. The nuclear receptor chicken ovalbumin upstream promoter transcription factor interacts with HIV-1 Tat and stimulates viral replication in human microglial cells. J Biol Chem. 2000;275:2654-60 pubmed
    ..These results suggest that COUP-TF is an essential transcription factor involved in HIV-1 expression in microglia and reveal a novel interplay of Tat and COUP-TF during regulation of viral expression. ..
  4. Lin F, Kolluri S, Chen G, Zhang X. Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor. J Biol Chem. 2002;277:21414-22 pubmed
    ..Thus, COUP-TF, through its physical interaction with AP-1, promotes anticancer effects of retinoids by potentiating their anti-AP-1 activity. ..
  5. Ing N, Beekman J, Tsai S, Tsai M, O Malley B. Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II). J Biol Chem. 1992;267:17617-23 pubmed
  6. Wang L, Tsai S, Cook R, Beattie W, Tsai M, O Malley B. COUP transcription factor is a member of the steroid receptor superfamily. Nature. 1989;340:163-6 pubmed
    ..We conclude that this superfamily of gene regulators contains proteins which bind and activate distal promoter elements of eukaryotic genes. ..
  7. Avram D, Fields A, Pretty On Top K, Nevrivy D, Ishmael J, Leid M. Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. J Biol Chem. 2000;275:10315-22 pubmed
  8. Métivier R, Gay F, Hübner M, Flouriot G, Salbert G, Gannon F, et al. Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK. EMBO J. 2002;21:3443-53 pubmed
    ..These data indicate an alternative interaction process between nuclear receptors and demonstrate a novel protein intercommunication pathway that modulates hER alpha AF-1. ..
  9. Le Dily F, Métivier R, Gueguen M, Le Péron C, Flouriot G, Tas P, et al. COUP-TFI modulates estrogen signaling and influences proliferation, survival and migration of breast cancer cells. Breast Cancer Res Treat. 2008;110:69-83 pubmed
    ..These results suggest that COUP-TFI selectively regulates the expression of endogenous E2-target genes and consequently modifies ER alpha positive mammary cells response to E2. ..

More Information

Publications132 found, 100 shown here

  1. Chai Y, Liu W, Wang C, Rao M, Zhang Y. Prognostic Role of Chicken Ovalbumin Upstream Promoter Transcription Factor II in Isocitrate Dehydrogenase-Mutant Glioma with 1p19q Co-Deletion. J Mol Neurosci. 2019;: pubmed publisher
    ..However, the role of NR2F2 in gliomas is unknown...
  2. Matsunami N, Shanmugam H, Baird L, Stevens J, Byrne J, Barnhart D, et al. Germline but not somatic de novo mutations are common in human congenital diaphragmatic hernia. Birth Defects Res. 2018;110:610-617 pubmed publisher
    ..not known to be associated with CDH, one patient with CDH and cardiac anomalies harbored a frameshift mutation in NR2F2 (aka COUP-TFII), generating a premature truncation of the protein...
  3. Kliewer S, Umesono K, Heyman R, Mangelsdorf D, Dyck J, Evans R. Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling. Proc Natl Acad Sci U S A. 1992;89:1448-52 pubmed
    ..Thus, these results support a general proposal in which the half-site spacing preferences may be used as a means to decipher potentially complex and interactive regulatory circuits. ..
  4. Bonzano S, Crisci I, Podleśny Drabiniok A, Rolando C, Krezel W, Studer M, et al. Neuron-Astroglia Cell Fate Decision in the Adult Mouse Hippocampal Neurogenic Niche Is Cell-Intrinsically Controlled by COUP-TFI In Vivo. Cell Rep. 2018;24:329-341 pubmed publisher
    ..Here, we show COUP-TFI/NR2F1 expression in DG NSCs and its downregulation upon neuroinflammation...
  5. Li S, Liu X, Zhou Y, Acharya A, Savkovic V, Xu C, et al. Shared genetic and epigenetic mechanisms between chronic periodontitis and oral squamous cell carcinoma. Oral Oncol. 2018;86:216-224 pubmed publisher
    ..Among 12 directly interacting cross-talk genes, NCAPH was significantly related with the prognosis of OSCC. NR2F2 had highest differential expression in CP and OSCC...
  6. Chiang M, Kuo C, Wang W, Hou T, Kuo C, Lu M, et al. Correlations between Histological and Array Comparative Genomic Hybridization Characterizations of Wilms Tumor. Pathol Oncol Res. 2019;: pubmed publisher
    ..Amplifications of NDUFV1, ZIC2, SIX1, NR2F2, MIR1469, SOX9, JAG1, MIR6870, and GNAS were found in all six Wilms tumors...
  7. Kashiwada T, Fukuhara S, Terai K, Tanaka T, Wakayama Y, Ando K, et al. β-Catenin-dependent transcription is central to Bmp-mediated formation of venous vessels. Development. 2015;142:497-509 pubmed publisher
    ..Bmp-mediated activation of β-catenin induces the expression of Nr2f2 (also known as Coup-TFII), a member of the nuclear receptor superfamily, to promote the differentiation of venous ..
  8. Borgen E, Rypdal M, Sosa M, Renolen A, Schlichting E, Lønning P, et al. NR2F1 stratifies dormant disseminated tumor cells in breast cancer patients. Breast Cancer Res. 2018;20:120 pubmed publisher
    ..Recently, experiments have shown that NR2F1 (COUP-TF1) plays a key role in dormancy signaling...
  9. Churko J, Garg P, Treutlein B, Venkatasubramanian M, Wu H, Lee J, et al. Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis. Nat Commun. 2018;9:4906 pubmed publisher
    ..with each cell population, we systematically tested the effect of a gain or loss of three transcription factors (NR2F2, TBX5, and HEY2), using CRISPR genome editing and ChIP-seq, in conjunction with patch clamp, calcium imaging, and ..
  10. Rosa A, Brivanlou A. A regulatory circuitry comprised of miR-302 and the transcription factors OCT4 and NR2F2 regulates human embryonic stem cell differentiation. EMBO J. 2011;30:237-48 pubmed publisher
    ..Here, we show that the transcriptional factors OCT4 and NR2F2 (COUP-TFII) and the miRNA miR-302 are linked in a regulatory circuitry that critically regulate both pluripotency ..
  11. Kumarasamy S, Waghulde H, Gopalakrishnan K, Mell B, Morgan E, Joe B. Mutation within the hinge region of the transcription factor Nr2f2 attenuates salt-sensitive hypertension. Nat Commun. 2015;6:6252 pubmed publisher
    Genome-wide association studies (GWAS) have prioritized a transcription factor, nuclear receptor 2 family 2 (NR2F2), as being associated with essential hypertension in humans...
  12. Flore G, Di Ruberto G, Parisot J, Sannino S, Russo F, Illingworth E, et al. Gradient COUP-TFI Expression Is Required for Functional Organization of the Hippocampal Septo-Temporal Longitudinal Axis. Cereb Cortex. 2017;27:1629-1643 pubmed publisher
  13. Tarchini B, Longo Guess C, Tian C, Tadenev A, Devanney N, Johnson K. A spontaneous mouse deletion in Mctp1 uncovers a long-range cis-regulatory region crucial for NR2F1 function during inner ear development. Dev Biol. 2018;443:153-164 pubmed publisher
    ..we serendipitously identified and started investigating the first reported long-range regulatory region for the Nr2f1 (Coup-TFI) transcription factor gene...
  14. Manikandan M, Abuelreich S, Elsafadi M, Alsalman H, Almalak H, Siyal A, et al. NR2F1 mediated down-regulation of osteoblast differentiation was rescued by bone morphogenetic protein-2 (BMP-2) in human MSC. Differentiation. 2018;104:36-41 pubmed publisher
    ..b>NR2F1 was among the highest expressed hHNR during osteogenesis, NR2F1 belongs to the steroid/thyroid hormone nuclear ..
  15. Lee E, Chan D. Implications of dried blood spot testing for congenital CMV on management of children with hearing loss: A preliminary report. Int J Pediatr Otorhinolaryngol. 2019;119:10-14 pubmed publisher
    ..Prognostic information afforded by etiologic confirmation of cCMV infection informed decision-making concerning cochlear implantation in these cases. ..
  16. Chen P, Li J, Zhao S, Yang J, Dou J, Wei C. [The treatment efficiency of a new ear moding device in the infants with congenital ear abnormalities]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017;31:849-853 pubmed publisher
    ..The sooner the noninvasive moding begins (especially within one week after birth), the better effect and the shorter treatment time the patients will achieve. ..
  17. Lacey M, Baribault C, Ehrlich K, Ehrlich M. Atherosclerosis-associated differentially methylated regions can reflect the disease phenotype and are often at enhancers. Atherosclerosis. 2019;280:183-191 pubmed publisher
    ..developmental transcription factor genes having little or no previous association with atherosclerosis, such as NR2F2 (COUP-TFII) and TBX18...
  18. Istrate M, Nussler A, Eichelbaum M, Burk O. Regulation of CYP3A4 by pregnane X receptor: The role of nuclear receptors competing for response element binding. Biochem Biophys Res Commun. 2010;393:688-93 pubmed publisher
    ..In summary, our results demonstrate that nuclear receptor binding to PXR response elements interferes with PXR-mediated expression and induction of CYP3A4 and thereby contributes to the interindividual variability of induction. ..
  19. Hino Fukuyo N, Kikuchi A, Arai Ichinoi N, Niihori T, Sato R, Suzuki T, et al. Genomic analysis identifies candidate pathogenic variants in 9 of 18 patients with unexplained West syndrome. Hum Genet. 2015;134:649-58 pubmed publisher novo mutations were identified in three cases, with two mutations occurring in two new candidate genes (NR2F1 and CACNA2D1) (21%, 3/14)...
  20. Al Turki S, Manickaraj A, Mercer C, Gerety S, Hitz M, Lindsay S, et al. Rare variants in NR2F2 cause congenital heart defects in humans. Am J Hum Genet. 2014;94:574-85 pubmed publisher
    ..AVSDs and identified five rare missense variants (two of which arose de novo) in the highly conserved gene NR2F2, a very significant enrichment (p = 7.7 × 10(-7)) compared to 5,194 control subjects...
  21. Bertacchi M, Parisot J, Studer M. The pleiotropic transcriptional regulator COUP-TFI plays multiple roles in neural development and disease. Brain Res. 2019;1705:75-94 pubmed publisher
    ..In this review, we will focus on COUP-TFI (or NR2F1), a nuclear receptor belonging to the superfamily of the steroid/thyroid hormone receptors, and considered to be ..
  22. Li A, Hanchard N, Furthner D, Fernbach S, Azamian M, Nicosia A, et al. Whole exome sequencing in 342 congenital cardiac left sided lesion cases reveals extensive genetic heterogeneity and complex inheritance patterns. Genome Med. 2017;9:95 pubmed publisher
    ..including 9 confirmed de novo variants in both novel and newly described human CVM candidate genes (ACVR1, JARID2, NR2F2, PLRG1, SMURF1) as well as established syndromic CVM genes (KMT2D, NF1, TBX20, ZEB2)...
  23. Arena M, Govers C, Lotti C, Ricciardi L, Wichers H, Mes J. The Effect of Tomatine on Gene Expression and Cell Monolayer Integrity in Caco-2. Molecules. 2018;23: pubmed publisher
    ..and on the expression levels of genes involved in cholesterol/sterol biosynthesis (LDLR), lipid metabolism (NR2F2), glucose and amino acid uptake (SGLT1, PAT1), cell cycle (PCNA, CDKN1A), apoptosis (CASP-3, BMF, KLF6), tight ..
  24. Shah J, Herrera S, Roberts D, Gunn G, Gidley P. Complications of tympanostomy tubes in head and neck cancer patients. Am J Otolaryngol. 2016;37:356-61 pubmed publisher
    ..Laryngectomy patients had a high rate of tympanostomy sequelae after radiotherapy. MTT for OM has high complication rates in HNC patients. ..
  25. Di Luoffo M, Brousseau C, Tremblay J. MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells. Andrology. 2016;4:335-44 pubmed publisher
    ..Recently, the transcription factors MEF2 and NR2F2 were identified in the mouse testis including in Leydig cells where they were found to regulate expression of ..
  26. Bringuier P, Schalken J, Hervieu V, Giroldi L. Involvement of orphan nuclear receptor COUP-TFII in cadherin-6 and cadherin-11 regulation: implications in development and cancer. Mech Dev. 2015;136:64-72 pubmed publisher
    ..Using transfection and RNA-interference we demonstrate that COUP-TFII (NR2F2) induces down-regulation of cadherin-6 and up-regulation of cadherin-11 in cultured cell lines...
  27. Sosa M, Parikh F, Maia A, Estrada Y, Bosch A, Bragado P, et al. NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes. Nat Commun. 2015;6:6170 pubmed publisher
    ..Here we find that the orphan nuclear receptor NR2F1 is epigenetically upregulated in experimental head and neck squamous cell carcinoma (HNSCC) dormancy models and in ..
  28. Tornari C, Towers E, Gale J, Dawson S. Regulation of the orphan nuclear receptor Nr2f2 by the DFNA15 deafness gene Pou4f3. PLoS ONE. 2014;9:e112247 pubmed publisher
    ..The orphan thyroid nuclear receptor Nr2f2 was identified as a POU4F3 target using a subtractive hybridization strategy and EMSA analysis showed that POU4F3 ..
  29. Pursani V, Bhartiya D, Tanavde V, Bashir M, Sampath P. Transcriptional activator DOT1L putatively regulates human embryonic stem cell differentiation into the cardiac lineage. Stem Cell Res Ther. 2018;9:97 pubmed publisher
    ..This included genes like MYOF, NR2F2, NKX2.5, and HAND1 in cardiac progenitors and cardiomyocytes, and POU5F1 and NANOG in pluripotent hES cells...
  30. Coviello A, Haring R, Wellons M, Vaidya D, Lehtimäki T, Keildson S, et al. A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation. PLoS Genet. 2012;8:e1002805 pubmed publisher
    ..3, p = 6.1 × 10(-35)), slco1b1 (rs4149056, 12p12.1, p = 1.9 × 10(-08)), nr2f2 (rs8023580, 15q26.2, p = 8.3 × 10(-12)), znf652 (rs2411984, 17q21.32, p = 3...
  31. Hill K, Chambers J, Jones B, Bolwell C, Aberdein D, Mills P. Trans-pinnal movement of methimazole: an in vitro study showing that methimazole can cross from the inner to outer pinna of cats. J Feline Med Surg. 2015;17:1005-11 pubmed publisher
    ..Substantial inter-individual variation was found. Further research is required in the area of transdermal penetration of drugs in cats. ..
  32. Quintero C, Laursen K, Mongan N, Luo M, Gudas L. CARM1 (PRMT4) Acts as a Transcriptional Coactivator during Retinoic Acid-Induced Embryonic Stem Cell Differentiation. J Mol Biol. 2018;430:4168-4182 pubmed publisher
    ..decrease in Rex1 (Zfp42) and for the RA induction of a subset of RA-regulated genes, including CRABP2 and NR2F1 (Coup-TF1)...
  33. Swift M, Pham V, Castranova D, Bell K, Poole R, Weinstein B. SoxF factors and Notch regulate nr2f2 gene expression during venous differentiation in zebrafish. Dev Biol. 2014;390:116-25 pubmed publisher
    ..The Shh/VEGF/Notch pathway is critical for arterial specification, while the orphan receptor nr2f2 (COUP-TFII) has been implicated in venous specification...
  34. Passaro A, Miselli M, Sanz J, Dalla Nora E, Morieri M, Colonna R, et al. Gene expression regional differences in human subcutaneous adipose tissue. BMC Genomics. 2017;18:202 pubmed publisher
    ..Interestingly, two molecular signature of visceral adipocyte lineage, homebox genes HOXA5 and NR2F1, are up-regulated in a-SAT versus g-SAT by a 2.5 fold change...
  35. Zhou X, Liu F, Tian M, Xu Z, Liang Q, Wang C, et al. Transcription factors COUP-TFI and COUP-TFII are required for the production of granule cells in the mouse olfactory bulb. Development. 2015;142:1593-605 pubmed publisher
    ..Taken together, these results suggest that COUP-TFI/II coordinately regulate the proliferation, migration and survival of a subpopulation of Pax6+ and CR+ granule cells in the OB. ..
  36. Jones S, Boisvert A, Naghi A, Hullin Matsuda F, Greimel P, Kobayashi T, et al. Stimulatory effects of combined endocrine disruptors on MA-10 Leydig cell steroid production and lipid homeostasis. Toxicology. 2016;355-356:21-30 pubmed publisher
    ..steroidogenic and cholesterol mediators Star, Cyp11a, Srb1 and Hsl, as well as upstream orphan nuclear receptors Nr2f2 and Sf1 were all significantly increased uniquely in the mixture treatment group...
  37. Lyu G, Zhang C, Ling T, Liu R, Zong L, Guan Y, et al. Genome and epigenome analysis of monozygotic twins discordant for congenital heart disease. BMC Genomics. 2018;19:428 pubmed publisher
    ..Particularly, ZIC3 and NR2F2 are found to have hypermethylated promoters in both the diseased twin and additional patients suffering from DORV...
  38. Cackowski F, Eber M, Rhee J, Decker A, Yumoto K, Berry J, et al. Mer Tyrosine Kinase Regulates Disseminated Prostate Cancer Cellular Dormancy. J Cell Biochem. 2017;118:891-902 pubmed publisher
    ..AXL or TYRO3 by shRNA in PCa cells induced a decreased ratio of P-Erk1/2 to P-p38, increased expression of p27, NR2F1, SOX2, and NANOG, induced higher levels of histone H3K9me3 and H3K27me3, and induced a G1/G0 arrest, all of which ..
  39. Singh S, Rajput Y, Barui A, Sharma R, Grover S. Expression of developmental genes in brown fat cells grown in vitro is linked with lipid accumulation. In Vitro Cell Dev Biol Anim. 2015;51:1003-11 pubmed publisher
    En1, Nr2f1, Gpc4, Sfrp2, Shox2, Tbx15 and Thbd are among the genes involved in development process of an organism in a number of tissues, in particular adipose tissue...
  40. Panaccione A, Chang M, Carbone B, Guo Y, Moskaluk C, Virk R, et al. NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem-Like Cells in Adenoid Cystic Carcinoma. Clin Cancer Res. 2016;22:2083-95 pubmed publisher
    ..activated NOTCH1 (N1ICD) and generated CD133(-)cells that expressed JAG1 as well as neural differentiation factors NR2F1, NR2F2, and p27Kip1...
  41. Su T, Stanley G, Sinha R, D Amato G, Das S, Rhee S, et al. Single-cell analysis of early progenitor cells that build coronary arteries. Nature. 2018;559:356-362 pubmed publisher
    ..The vein-specifying transcription factor COUP-TF2 (also known as NR2F2) prevented plexus cells from overcoming the pre-artery threshold by inducing cell cycle genes...
  42. Dimassi S, Labalme A, Ville D, Calender A, Mignot C, Boutry Kryza N, et al. Whole-exome sequencing improves the diagnosis yield in sporadic infantile spasm syndrome. Clin Genet. 2016;89:198-204 pubmed publisher
    ..The fourth mutation was an in-frame deletion (p.Phe110del) in NR2F1, a gene whose mutations cause intellectual disability, epilepsy, and optic atrophy...
  43. Li R, Wu T, Mou Y, Wang Y, Chen C, Wu C. Nr2f1b control venous specification and angiogenic patterning during zebrafish vascular development. J Biomed Sci. 2015;22:104 pubmed publisher
    ..The orphan nuclear receptor Chicken ovalbumin upstream promoter transcription factor II (CoupTFII, a.k.a NR2F2) positively regulates vein identity in mice...
  44. Bosch D, Boonstra F, de Leeuw N, Pfundt R, Nillesen W, de Ligt J, et al. Novel genetic causes for cerebral visual impairment. Eur J Hum Genet. 2016;24:660-5 pubmed publisher
    ..After classification, variants in four genes known to be associated with CVI (AHDC1, NGLY1, NR2F1, PGAP1) in 5 patients (20%) were identified, establishing a conclusive genetic diagnosis for CVI...
  45. Feng Q, Wu X, Li F, Ning B, Lu X, Zhang Y, et al. miR-27b inhibits gastric cancer metastasis by targeting NR2F2. Protein Cell. 2017;8:114-122 pubmed publisher
    Increasing attention is focused on the down-regulation of miRNAs in cancer process. Nuclear receptor subfamily 2 (NR2F2, also known as COUP-TFII) is involved in the development of many types of cancers, but its role in gastric cancer ..
  46. Rastetter R, Bernard P, Palmer J, Chassot A, Chen H, Western P, et al. Marker genes identify three somatic cell types in the fetal mouse ovary. Dev Biol. 2014;394:242-52 pubmed publisher
    ..Strikingly, a third somatic cell population can be identified, marked by the expression of NR2F2, which is expressed in LGR5- and FOXL2 double-negative ovarian somatic cells...
  47. Wang M, Zhou Z, Khan M, Gao J, Loor J. Clock circadian regulator (CLOCK) gene network expression patterns in bovine adipose, liver, and mammary gland at 3 time points during the transition from pregnancy into lactation. J Dairy Sci. 2015;98:4601-12 pubmed publisher
    ..No interaction was detected for CLOCK, CRY2, PER1, and PER3. In general, the expression of NPAS2, NR1D1, NR2F2, ALAS1, FECH, FBXW11, CCRN4L, PPARA, PPARGC1A, and FGF21 was lower at -10 d but increased postpartum in all ..
  48. Quaranta R, Fell J, Rühle F, Rao J, Piccini I, Arauzo Bravo M, et al. Revised roles of ISL1 in a hES cell-based model of human heart chamber specification. elife. 2018;7: pubmed publisher
    ..with the retinoic acid pathway for prospective cardiomyocyte fate, which converges on the atrial specifier NR2F1. This study reveals a core regulatory network putatively controlling human heart chamber formation and also bears ..
  49. Bashamboo A, Eozenou C, Jorgensen A, Bignon Topalovic J, Siffroi J, Hyon C, et al. Loss of Function of the Nuclear Receptor NR2F2, Encoding COUP-TF2, Causes Testis Development and Cardiac Defects in 46,XX Children. Am J Hum Genet. 2018;102:487-493 pubmed publisher
    ..We identified heterozygous frameshift mutations in NR2F2, encoding COUP-TF2, in three children. One carried a c.103_109delGGCGCCC (p...
  50. Boogerd C, Zhu X, Aneas I, Sakabe N, Zhang L, Sobreira D, et al. Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development. Circ Res. 2018;: pubmed publisher
    ..Notably, TBX20 bound a conserved enhancer for a gene key to atrial development and identity, COUP-TFII/Nr2f2 This enhancer interacted with the NR2F2 promoter in human cardiomyocytes and conferred atrial specific ..
  51. Teratani Ota Y, Yamamizu K, Piao Y, Sharova L, Amano M, Yu H, et al. Induction of specific neuron types by overexpression of single transcription factors. In Vitro Cell Dev Biol Anim. 2016;52:961-973 pubmed
    ..The majority of neuron-like cells generated by induction of Ascl1, Smad7, Nr2f1, Dlx2, Dlx4, Nr2f2, Barhl2, and Lhx1 were GABA-positive and expressed other markers of GABAergic neurons...
  52. Woo K, Kang B, Min J, Park J, Kim A, Oh K. Postoperative pain control by preventive intercostal nerve block under direct vision followed by catheter-based infusion of local analgesics in rib cartilage harvest for auricular reconstruction in children with microtia: A randomized controlled tria. J Plast Reconstr Aesthet Surg. 2016;69:1203-10 pubmed publisher
    ..The clinical trial registration number: WHO ICTRP, (KCT0001668)). ..
  53. Martin Hernandez E, Rodríguez García M, Chen C, Cotrina Vinagre F, Carnicero Rodríguez P, Bellusci M, et al. Mitochondrial involvement in a Bosch-Boonstra-Schaaf optic atrophy syndrome patient with a novel de novo NR2F1 gene mutation. J Hum Genet. 2018;63:525-528 pubmed publisher
    ..286A>G:p.Lys96Glu) that encodes for the COUP transcription factor 1 protein (COUP-TF1)...
  54. Delépine C, Nectoux J, Letourneur F, Baud V, Chelly J, Billuart P, et al. Astrocyte Transcriptome from the Mecp2(308)-Truncated Mouse Model of Rett Syndrome. Neuromolecular Med. 2015;17:353-63 pubmed publisher
    ..Moreover, transcriptional profiling revealed altered Nr2f2 expression which may explain down- and upregulation of several target genes in astrocytes such as Ccl2, Lcn2 and ..
  55. Zhu N, Wang H, Wang B, Wei J, Shan W, Feng J, et al. A Member of the Nuclear Receptor Superfamily, Designated as NR2F2, Supports the Self-Renewal Capacity and Pluripotency of Human Bone Marrow-Derived Mesenchymal Stem Cells. Stem Cells Int. 2016;2016:5687589 pubmed publisher
    Mesenchymal stem cells are characterized with self-renewal capacity and pluripotency. NR2F2 is a nuclear receptor that has been detected in the mesenchymal compartment of developing organs...
  56. Molinari E, Bar H, Pyle A, Patrizio P. Transcriptome analysis of human cumulus cells reveals hypoxia as the main determinant of follicular senescence. Mol Hum Reprod. 2016;22:866-76 pubmed publisher
    ..o., genes involved in the hypoxia stress response (NOS2, RORA and NR4A3), vasculature development (NR2F2, PTHLH), glycolysis (RALGAPA2 and TBC1D4) and cAMP turnover (PDE4D) were significantly overexpressed when compared ..
  57. Larsen Z, Chander P, Joyner J, Floruta C, Demeter T, Weick J. Effects of Ethanol on Cellular Composition and Network Excitability of Human Pluripotent Stem Cell-Derived Neurons. Alcohol Clin Exp Res. 2016;40:2339-2350 pubmed publisher
    ..g., GSX2, DLX1/2/5/6, NR2F2) as well as mature IN specification (e.g., SST, NPY)...
  58. Lu K, Keen H, Weatherford E, Sequeira Lopez M, Gomez R, Sigmund C. Estrogen Receptor α Is Required for Maintaining Baseline Renin Expression. Hypertension. 2016;67:992-9 pubmed publisher
    ..1 cells. We also observed that previously characterized negative regulators of renin expression, Nr2f2 and vitamin D receptor, exhibited elevated expression in response to ERα inhibition...
  59. Qin X, Tatsukawa H, Hitomi K, Shirakami Y, Ishibashi N, Shimizu M, et al. Metabolome Analyses Uncovered a Novel Inhibitory Effect of Acyclic Retinoid on Aberrant Lipogenesis in a Mouse Diethylnitrosamine-Induced Hepatic Tumorigenesis Model. Cancer Prev Res (Phila). 2016;9:205-14 pubmed publisher
    ..a key transcription regulator of both embryogenesis and tumorigenesis, COUP transcription factor 2, also known as NR2F2, was associated with the metabolic effect of ACR in human hepatocellular carcinoma cells...
  60. Yang X, Feng S, Tang K. COUP-TF Genes, Human Diseases, and the Development of the Central Nervous System in Murine Models. Curr Top Dev Biol. 2017;125:275-301 pubmed publisher
    ..Clearly, the investigations on the functions of COUP-TF genes in the developing mouse central nervous system will benefit not only the understanding of neurodevelopment, but also the etiology of human mental diseases. ..
  61. Hackley S. Evidence for a vestigial pinna-orienting system in humans. Psychophysiology. 2015;52:1263-70 pubmed publisher
    ..It is suggested that the postauricular reflex to sudden, intense sounds constitutes a vestigial startle response, but that the reflex arc is dominated by a pathway that bypasses the main organizing center for startle. ..
  62. Rouault C, Clément K, Guesnon M, Henegar C, Charles M, Heude B, et al. Transcriptomic signatures of villous cytotrophoblast and syncytiotrophoblast in term human placenta. Placenta. 2016;44:83-90 pubmed publisher
    ..In silico, all networks were linked to 3 transcriptional regulators (PPARγ, RARα and NR2F1) which are known to be essential for trophoblast differentiation...
  63. Zhu N, Wang H, Wei J, Wang B, Shan W, Lai X, et al. NR2F2 regulates bone marrow-derived mesenchymal stem cell-promoted proliferation of Reh cells. Mol Med Rep. 2016;14:1351-6 pubmed publisher
    ..The data of the present study demonstrated that BM?MSCs promote the proliferation of Reh cells and the NR2F2 mRNA and protein levels were elevated in BM?MSCs following co?culture...
  64. High F, Bhayani P, Wilson J, Bult C, Donahoe P, Longoni M. De novo frameshift mutation in COUP-TFII (NR2F2) in human congenital diaphragmatic hernia. Am J Med Genet A. 2016;170:2457-61 pubmed publisher
    COUP-TFII (NR2F2) is mapped to the 15q26 deletion hotspot associated with the common and highly morbid congenital diaphragmatic hernia (CDH)...
  65. Hino Fukuyo N, Kikuchi A, Yokoyama H, Iinuma K, Hirose M, Haginoya K, et al. Long-term outcome of a 26-year-old woman with West syndrome and an nuclear receptor subfamily 2 group F member 1 gene (NR2F1) mutation. Seizure. 2017;50:144-146 pubmed publisher
    Long-term outcome of West syndrome with a NR2F1 mutation.
  66. Zhou B, Song J, Han T, Huang M, Jiang H, Qiao H, et al. MiR-382 inhibits cell growth and invasion by targeting NR2F2 in colorectal cancer. Mol Carcinog. 2016;55:2260-2267 pubmed publisher
    ..However, the role of miR-382 in CRC has not been sufficiently investigated. NR2F2 (also known as COUP-TFII), a member of the steroid/thyroid receptor superfamily, is often aberrantly activated in ..
  67. Garattini E, Bolis M, Gianni M, Paroni G, Fratelli M, Terao M. Lipid-sensors, enigmatic-orphan and orphan nuclear receptors as therapeutic targets in breast-cancer. Oncotarget. 2016;7:42661-42682 pubmed publisher
    ..The Enigmatic-Orphans, NR1F1 NR2A1 and NR3B3 as well as the Orphan-Receptors, NR0B1, NR0B2, NR1D1, NR2F1, NR2F2 and NR4A3 exert a similar action...
  68. Tonchev A, Tuoc T, Rosenthal E, Studer M, Stoykova A. Zbtb20 modulates the sequential generation of neuronal layers in developing cortex. Mol Brain. 2016;9:65 pubmed publisher
    ..Zbtb20 implements these temporal effects in part by binding to promoter of the orphan nuclear receptor CoupTF1/Nr2f1...
  69. Tan I, Wojcinski A, Rallapalli H, Lao Z, Sanghrajka R, Stephen D, et al. Lateral cerebellum is preferentially sensitive to high sonic hedgehog signaling and medulloblastoma formation. Proc Natl Acad Sci U S A. 2018;115:3392-3397 pubmed publisher
    ..GCP gene-expression profiles, and found that deletion of the genes most highly expressed in the hemispheres (Nr2f2) or vermis (Engrailed1) showed opposing effects on GCP differentiation...
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    Both nuclear receptor subfamily 2 group F member 1 (NR2F1) and microRNAs (miRNAs) have been shown to play critical roles in the developing and functional inner ear...
  71. Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, et al. Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other. Nucleic Acids Res. 1988;16:11057-74 pubmed
    ..Hybridization analysis of DNAs from sorted chromosomes shows that the ear-2 gene is located on chromosome 19 and ear-3 on chromosome 5, indicating that the two genes are clearly different from each other. ..
  72. Johnston S, Yu X, Mertz J. The major transcriptional transactivation domain of simian virus 40 large T antigen associates nonconcurrently with multiple components of the transcriptional preinitiation complex. J Virol. 1996;70:1191-202 pubmed
    ..Rather, we hypothesize that transactivation by Tag may primarily occur by removing or preventing the binding of factors that inhibit the formation of preinitiation complexes. ..
  73. Klinge C, Silver B, Driscoll M, Sathya G, Bambara R, Hilf R. Chicken ovalbumin upstream promoter-transcription factor interacts with estrogen receptor, binds to estrogen response elements and half-sites, and inhibits estrogen-induced gene expression. J Biol Chem. 1997;272:31465-74 pubmed
  74. Montemayor C, Montemayor O, Ridgeway A, Lin F, Wheeler D, Pletcher S, et al. Genome-wide analysis of binding sites and direct target genes of the orphan nuclear receptor NR2F1/COUP-TFI. PLoS ONE. 2010;5:e8910 pubmed publisher a proof of principle, utilize the methodology to identify novel direct targets of the orphan nuclear receptor NR2F1 (COUP-TFI)...
  75. Zhang T, Li X, Zhang D, Liu X, Zhao F, Lin X, et al. Repression of COUP-TFI Improves Bone Marrow-Derived Mesenchymal Stem Cell Differentiation into Insulin-Producing Cells. Mol Ther Nucleic Acids. 2017;8:220-231 pubmed publisher
    ..The differentiation of bmMSCs into IPCs could be improved by knockdown of COUP-TFI, which may provide a novel stem cell-based therapy for T1D. ..
  76. Zhang Y, Dufau M. Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor. J Biol Chem. 2000;275:2763-70 pubmed by yeast one-hybrid screening of a human placenta cDNA library revealed three nuclear orphan receptors, EAR2, EAR3/COUP-TFI, and TR4...
  77. Kurtev V, Margueron R, Kroboth K, Ogris E, Cavailles V, Seiser C. Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases. J Biol Chem. 2004;279:24834-43 pubmed
    ..We, therefore, propose a novel function for REA as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. ..
  78. Zhang L, Liu X, Gafken P, Kioussi C, Leid M. A chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) complex represses expression of the gene encoding tumor necrosis factor alpha-induced protein 8 (TNFAIP8). J Biol Chem. 2009;284:6156-68 pubmed publisher
    The orphan nuclear receptor chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) plays key roles in development and homeostasis...
  79. Saraswat G, Guha R, Mondal K, Saha P, Banerjee S, Chakraborty P, et al. Molecular cues to the anti-implantation effect of nano-puerarin in rats. Reproduction. 2016;151:693-707 pubmed publisher
    ..PN also efficiently ablated the Ihh-Nr2f2-Bmp2 signalling pathway and invited the loss of uterine potential for decidualization...
  80. Pursani V, Pethe P, Bashir M, Sampath P, Tanavde V, Bhartiya D. Genetic and Epigenetic Profiling Reveals EZH2-mediated Down Regulation of OCT-4 Involves NR2F2 during Cardiac Differentiation of Human Embryonic Stem Cells. Sci Rep. 2017;7:13051 pubmed publisher
    ..ChIP and sequential ChIP were employed to study role of transcription factor NR2F2 during hES cells differentiation...
  81. Dai K, Hussain M. NR2F1 disrupts synergistic activation of the MTTP gene transcription by HNF-4? and HNF-1?. J Lipid Res. 2012;53:901-8 pubmed publisher
    ..that MTTP gene expression was repressed in nondifferentiated intestinal cells by nuclear receptor 2 family 1 (NR2F1). However, mechanisms involved in the repression of MTP by NR2F1 were not elucidated...
  82. Varga C, Tamas G, Barzo P, Oláh S, Somogyi P. Molecular and Electrophysiological Characterization of GABAergic Interneurons Expressing the Transcription Factor COUP-TFII in the Adult Human Temporal Cortex. Cereb Cortex. 2015;25:4430-49 pubmed publisher
    ..In conclusion, COUP-TFII is expressed in a diverse subset of GABAergic interneurons predominantly innervating small dendritic shafts originating from both interneurons and pyramidal cells. ..
  83. Wang J, Hua L, Chen J, Zhang J, Bai X, Gao B, et al. Identification and characterization of long non-coding RNAs in subcutaneous adipose tissue from castrated and intact full-sib pair Huainan male pigs. BMC Genomics. 2017;18:542 pubmed publisher
    ..and found it mainly expressed in the cell nucleus and target the Nuclear Receptor Subfamily 2 Group F Member 2 (NR2F2) gene...
  84. Kim J, Kim D, Yu M, Cha M, Yu S, Kang J. Role of epigenetics in the pathogenesis of chronic rhinosinusitis with nasal polyps. Mol Med Rep. 2017;: pubmed publisher
    ..altered hypomethylation in NP tissues were, Keratin 19 (KRT19), nuclear receptor subfamily 2 group F member 2 (NR2F2), A Disintegrin?like And Metallopeptidase (Reprolysin Type) with Thrombospondin type 1 motif 1 (ADAMTS1) and zinc ..
  85. Chen Y, Huang H, Lin C. Regulatory feedback loops bridge the human gene regulatory network and regulate carcinogenesis. Brief Bioinform. 2017;: pubmed publisher
    ..More importantly, we identified one regulatory FBL between HNF4A and NR2F2 that possesses the highest bridgeness in the interface core...
  86. Gay F, Anglade I, Gong Z, Salbert G. The LIM/homeodomain protein islet-1 modulates estrogen receptor functions. Mol Endocrinol. 2000;14:1627-48 pubmed
    ..Taken together, these data suggest that ISL1-ER cross-talk could differentially regulate the expression of ER and ISL1 target genes. ..
  87. You M, Fischer M, Cho W, Crabb D. Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors. Arch Biochem Biophys. 2002;398:79-86 pubmed
    ..These data suggest that ALDH2 expression can be suppressed by cAMP, most likely through phosphorylation of HNF4 by PKA, and this may account for the reduction in enzyme protein during fasting. ..
  88. Zhang Y, Dufau M. Repression of the luteinizing hormone receptor gene promoter by cross talk among EAR3/COUP-TFI, Sp1/Sp3, and TFIIB. Mol Cell Biol. 2003;23:6958-72 pubmed
    ..receptor (LHR) gene is activated by Sp1/Sp3 at two Sp1 sites and is repressed by nuclear orphan receptors EAR2 and EAR3 through a direct-repeat (DR) motif...
  89. Kardon G, Ackerman K, McCulley D, Shen Y, Wynn J, Shang L, et al. Congenital diaphragmatic hernias: from genes to mechanisms to therapies. Dis Model Mech. 2017;10:955-970 pubmed publisher
    ..affected genes identified in CDH patients include transcription factors, such as GATA4, ZFPM2, NR2F2 and WT1, and signaling pathway components, including members of the retinoic acid pathway...
  90. Kaiwar C, Zimmermann M, Ferber M, Niu Z, Urrutia R, Klee E, et al. Novel NR2F1 variants likely disrupt DNA binding: molecular modeling in two cases, review of published cases, genotype-phenotype correlation, and phenotypic expansion of the Bosch-Boonstra-Schaaf optic atrophy syndrome. Cold Spring Harb Mol Case Stud. 2017;3: pubmed publisher
    Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS) is a recently described autosomal dominant disorder caused by mutations in the NR2F1 gene. There are presently 28 cases of BBSOAS described in the literature...
  91. Klinge C, Kaur K, Swanson H. The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1. Arch Biochem Biophys. 2000;373:163-74 pubmed
  92. Lethimonier C, Flouriot G, Kah O, Ducouret B. The glucocorticoid receptor represses the positive autoregulation of the trout estrogen receptor gene by preventing the enhancer effect of a C/EBPbeta-like protein. Endocrinology. 2002;143:2961-74 pubmed
    ..Indeed, GR, through its DNA-binding domain, suppresses the binding of C/EBPbeta on the rtER promoter by protein-protein interactions and thereby prevents the enhancer effect of this transcription factor. ..