NR2B

Summary

Gene Symbol: NR2B
Description: glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Alias: GluN2B, MRD6, NMDAR2B, NR2B, hNR3, N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 3, NR3, glutamate [NMDA] receptor subunit epsilon-2, glutamate receptor ionotropic, NMDA 2B, glutamate receptor subunit epsilon-2
Species: human

Top Publications

  1. doi Long-term potentiation in the nucleus accumbens requires both NR2A- and NR2B-containing N-methyl-D-aspartate receptors
    Sietske M Schotanus
    The Karolinska Institute, Department of Physiology and Pharmacology, Section of Molecular Neurophysiology, Stockholm, Sweden
    Eur J Neurosci 27:1957-64. 2008
  2. doi Late phase of long-term potentiation induced by co-application of N-methyl-d-aspartic acid and the antagonist of NR2B-containing N-methyl-d-aspartic acid receptors in rat hippocampus
    A Oh-Nishi
    Division of Brain Science, Kitasato University Graduate School of Medical Sciences, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Neuroscience 159:127-35. 2009
  3. doi SGK1 phosphorylation of IkappaB Kinase alpha and p300 Up-regulates NF-kappaB activity and increases N-Methyl-D-aspartate receptor NR2A and NR2B expression
    Derek J C Tai
    Graduate Institute of Life Sciences, National Defense Medical Center, Academia Sinica, Taipei 115, Taiwan
    J Biol Chem 284:4073-89. 2009
  4. pmc Platelet-derived growth factor selectively inhibits NR2B-containing N-methyl-D-aspartate receptors in CA1 hippocampal neurons
    Michael A Beazely
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 284:8054-63. 2009
  5. doi Differentiated P19 cells express N-methyl-D-aspartate receptor 1 mRNA binding trans-acting proteins and four N-methyl-D-aspartate receptor 1 splice variants comparable to those in cultured fetal cortical neurons
    Antje Anji
    Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506, USA
    J Neurosci Res 87:1591-601. 2009
  6. ncbi Association analysis of polymorphisms in the N-methyl-D-aspartate (NMDA) receptor subunit 2B (GRIN2B) gene and tardive dyskinesia in schizophrenia
    Ying Jay Liou
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Psychiatry Res 153:271-5. 2007
  7. doi Phosphorylation status of the NR2B subunit of NMDA receptor regulates its interaction with calcium/calmodulin-dependent protein kinase II
    Rajeevkumar Raveendran
    Rajiv Gandhi Centre for Biotechnology, Thycaud, P O, Thiruvananthapuram 695014, Kerala, India
    J Neurochem 110:92-105. 2009
  8. ncbi Genetic enhancement of learning and memory in mice
    Y P Tang
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014, USA
    Nature 401:63-9. 1999
  9. ncbi Identification of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor
    R V Omkumar
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 271:31670-8. 1996
  10. doi Differential genetic susceptibility in diphasic and peak-dose dyskinesias in Parkinson's disease
    Jee Young Lee
    Department of Neurology, Seoul National University Boramae Hospital, Seoul, Korea
    Mov Disord 26:73-9. 2011

Research Grants

  1. MOLECULAR PHARMACOLOGY OF NMDA RECEPTORS
    Keith Williams; Fiscal Year: 1999
  2. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2010
  3. Role of LGI1 in Autosomal Dominant Lateral Temporal Lobe Epilepsy
    Matthew P Anderson; Fiscal Year: 2010
  4. Structure and Function of NMDA Receptors
    Hiroyasu Furukawa; Fiscal Year: 2010
  5. Mechanism of action of novel subunit-selective NMDA receptor modulators
    Stephen F Traynelis; Fiscal Year: 2010
  6. The Role of Gliotransmission in Cerebral Ischemia
    Shinghua Ding; Fiscal Year: 2010
  7. MOLECULAR STUDIES OF BRAIN NMDA RECEPTORS
    R Suzanne Zukin; Fiscal Year: 2007
  8. MOLECULAR STUDIES OF BRAIN NMDA RECEPTORS
    R Suzanne Zukin; Fiscal Year: 2009
  9. Steroids-Functional Modulators of Amino Acid Receptors
    DAVID FARB; Fiscal Year: 2007
  10. NEOCORTICAL EPILEPSY DURING DEVELOPMENT
    JOHN HABLITZ; Fiscal Year: 2005

Detail Information

Publications187 found, 100 shown here

  1. doi Long-term potentiation in the nucleus accumbens requires both NR2A- and NR2B-containing N-methyl-D-aspartate receptors
    Sietske M Schotanus
    The Karolinska Institute, Department of Physiology and Pharmacology, Section of Molecular Neurophysiology, Stockholm, Sweden
    Eur J Neurosci 27:1957-64. 2008
    ..However, the contribution of NR2B in the induction of LTP is not always clearly established...
  2. doi Late phase of long-term potentiation induced by co-application of N-methyl-d-aspartic acid and the antagonist of NR2B-containing N-methyl-d-aspartic acid receptors in rat hippocampus
    A Oh-Nishi
    Division of Brain Science, Kitasato University Graduate School of Medical Sciences, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Neuroscience 159:127-35. 2009
    ..a brief bath co-application of a low concentration of NMDA, an agonist of NMDARs, and the selective antagonist of NR2B-containing NMDARs, (alpha R, beta S)-alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidinepropanol (..
  3. doi SGK1 phosphorylation of IkappaB Kinase alpha and p300 Up-regulates NF-kappaB activity and increases N-Methyl-D-aspartate receptor NR2A and NR2B expression
    Derek J C Tai
    Graduate Institute of Life Sciences, National Defense Medical Center, Academia Sinica, Taipei 115, Taiwan
    J Biol Chem 284:4073-89. 2009
    ..SGK1 enhanced nuclear factor kappaB (NF-kappaB) activity and up-regulated N-methyl-d-aspartate receptor NR2A and NR2B expression through activation of IKKalpha at Thr-23 and Ser-180, and these two residues play an equally important ..
  4. pmc Platelet-derived growth factor selectively inhibits NR2B-containing N-methyl-D-aspartate receptors in CA1 hippocampal neurons
    Michael A Beazely
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 284:8054-63. 2009
    ..hippocampus, the majority of NMDA receptors are heteromeric; most are composed of 2 NR1 subunits and 2 NR2A or 2 NR2B subunits...
  5. doi Differentiated P19 cells express N-methyl-D-aspartate receptor 1 mRNA binding trans-acting proteins and four N-methyl-D-aspartate receptor 1 splice variants comparable to those in cultured fetal cortical neurons
    Antje Anji
    Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506, USA
    J Neurosci Res 87:1591-601. 2009
    ..Total RNA and protein extracts from differentiated P19 cells were utilized to examine NR1 and NR2B expression...
  6. ncbi Association analysis of polymorphisms in the N-methyl-D-aspartate (NMDA) receptor subunit 2B (GRIN2B) gene and tardive dyskinesia in schizophrenia
    Ying Jay Liou
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Psychiatry Res 153:271-5. 2007
    ..We conclude that genetic variations in the human GRIN2B gene probably do not play a major role in susceptibility to, or severity of TD...
  7. doi Phosphorylation status of the NR2B subunit of NMDA receptor regulates its interaction with calcium/calmodulin-dependent protein kinase II
    Rajeevkumar Raveendran
    Rajiv Gandhi Centre for Biotechnology, Thycaud, P O, Thiruvananthapuram 695014, Kerala, India
    J Neurochem 110:92-105. 2009
    ..of post-synaptic Ca(2+)/calmodulin-dependent protein kinase type II (CaMKII) and its translocation to the NR2B subunit of NMDA receptor. The major binding site for CaMKII on NR2B undergoes phosphorylation at Ser1303, in vivo...
  8. ncbi Genetic enhancement of learning and memory in mice
    Y P Tang
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014, USA
    Nature 401:63-9. 1999
    ..Here we show that overexpression of NMDA receptor 2B (NR2B) in the forebrains of transgenic mice leads to enhanced activation of NMDA receptors, facilitating synaptic ..
  9. ncbi Identification of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor
    R V Omkumar
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 271:31670-8. 1996
    ..L., and MacDonald, J. F. (1994) Nature 369, 230-232). Here we identify a major phosphorylation site on subunit NR2B that is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (CaM kinase II), an abundant protein kinase ..
  10. doi Differential genetic susceptibility in diphasic and peak-dose dyskinesias in Parkinson's disease
    Jee Young Lee
    Department of Neurology, Seoul National University Boramae Hospital, Seoul, Korea
    Mov Disord 26:73-9. 2011
    ..There may be a genetic susceptibility in the development of DDSK in PD patients on chronic levodopa therapy, and its underlying pathophysiological mechanism might be distinct from that of PDSK...
  11. ncbi Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor
    N M Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Mol Psychiatry 7:508-14. 2002
    ..2). These SNPs will therefore be suitable for studying neuropsychiatric phenotypes that are putatively related to NMDA dysfunction. Pooled analysis provided no support for association between any of the GRIN genes and schizophrenia...
  12. ncbi mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit
    A M Schito
    Institute of Biology and Genetics, University of Genoa, Italy
    Neurosci Lett 239:49-53. 1997
    The expression of the N-methyl-D-aspartate (NMDA) receptor subunit NR2B/epsilon2 (GRIN2B) in the human adult brain was assayed by in situ hybridisation, by using a specific cRNA probe. The full length GRIN2B cDNA was cloned and sequenced...
  13. ncbi Quantitative hypermethylation of NMDAR2B in human gastric cancer
    Jun Wei Liu
    Department of Otolaryngology, Division of Head and Neck Cancer Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J Cancer 121:1994-2000. 2007
    NMDA receptor Type 2B (NMDAR2B) is a candidate TSG first identified in esophageal squamous cell carcinoma (ESCC)...
  14. ncbi NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in a sex-specific manner
    Larissa Arning
    Department of Human Genetics, Ruhr University, 44780 Bochum, Germany
    Hum Genet 122:175-82. 2007
    ..g. variations in the NR2A and NR2B glutamate receptor subunit genes (GRIN2A, GRIN2B)...
  15. ncbi NR2A and NR2B receptor gene variations modify age at onset in Huntington disease
    Larissa Arning
    Department of Human Genetics, Ruhr University Bochum, Universitatsstrasse 150, 44801 Bochum, Germany
    Neurogenetics 6:25-8. 2005
    ..5% to GRIN2A genotype variation. We conclude that these two genes, coding for NR2B and NR2A subtypes mainly expressed in the striatum, may influence the variability in AO of HD...
  16. ncbi Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current
    G Y Liao
    Laboratory of Integrative Neuroscience, Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA
    Mol Pharmacol 59:960-4. 2001
    ..Experiments using chimeras initially indicated that the cytoplasmic C-terminal tails of NR2B (responsive to PKC) and NR2C (unresponsive to PKC) subunits contain the amino acid residues responsible for the ..
  17. ncbi Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex
    K Jo
    Department of Physiology, School of Medicine, University of California at San Francisco, San Francisco, California 94143 0444, USA
    J Neurosci 19:4189-99. 1999
    ..This work suggests a role for MALS proteins in regulating recruitment of neurotransmitter receptors to the PSD...
  18. ncbi Phosphorylation-dependent interaction of the N-methyl-D-aspartate receptor epsilon 2 subunit with phosphatidylinositol 3-kinase
    C Hisatsune
    Department of Oncology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Genes Cells 4:657-66. 1999
    ....
  19. ncbi Striatal neurons but not nigral dopaminergic neurons in neonatal primary cell culture express endogenous functional N-methyl-D-aspartate receptors
    P W Lui
    Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, PR China
    Brain Res Mol Brain Res 120:9-21. 2003
    ..In striatal neurons, NR1, NR2A and NR2B mRNAs and immunoreactivity, and NR2D mRNA were found and the maximal levels of NR1 mRNA and immunoreactivity ..
  20. ncbi Role of N-methyl-D-aspartate receptors in gastric mucosal blood flow induced by histamine
    Li Hsueh Tsai
    Department of Physiology, School of Medicine, Taipei Medical University, Taipei, Taiwan
    J Neurosci Res 77:730-8. 2004
    ..inhibit histamine-stimulated GMBF and to examine the expression patterns of NMDA receptor subunits NR1, NR2A, and NR2B in rat stomach. Laser Doppler flowmetry was used to measure gastric blood flow in anesthetized rats...
  21. ncbi Use of trifluoroperazine isolates a [(3)H]Ifenprodil binding site in rat brain membranes with the pharmacology of the voltage-independent ifenprodil site on N-methyl-D-aspartate receptors containing NR2B subunits
    L L Coughenour
    Department of Neuroscience Therapeutics, Pfizer Global Research and Development, Ann Arbor Laboratories, Ann Arbor, Michigan 48105, USA
    J Pharmacol Exp Ther 296:150-9. 2001
    ..binding to a single high affinity state with the pharmacology of N-methyl-D-aspartate (NMDA) receptors containing NR2B subunits...
  22. doi 3-mercaptopropionic acid-induced seizures decrease NR2B expression in Purkinje cells: cyclopentyladenosine effect
    E Girardi
    Instituto de Biología Celular y Neurociencia, Facultad de Medicina, Universidad de Buenos Aires and Consejo Nacional de Investigaciones Científicas y Técnicas CONICET, Paraguay 2155, Buenos Aires, Argentina
    Cell Mol Neurobiol 30:985-90. 2010
    ..In mature Purkinje cells, the combination of NR1 with NR2B subunits forms functional NMDARs; NR2B subunit may be altered in exocitotoxic events...
  23. ncbi Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors
    S Vicini
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007, USA
    J Neurophysiol 79:555-66. 1998
    ..outside-out membrane patches excised from cells expressing recombinant NR1 subunits in combination with the NR2A, NR2B, NR2C, or NR2D NMDA receptor subunits...
  24. ncbi Selective subunit antagonists suggest an inhibitory relationship between NR2B and NR2A-subunit containing N-methyl-D: -aspartate receptors in hippocampal slices
    Andrew P Mallon
    Institute of Biomedical and Life Sciences, Division of Neuroscience and Biomedical Systems, West Medical Building, University of Glasgow, Glasgow
    Exp Brain Res 162:374-83. 2005
    ..Here, we have examined the effects of selective antagonists of NR2A and NR2B subunits (NVP-AAM07 and Ro25-6981 respectively) on the effects of NMDA in the CA1 field of rat hippocampal slices...
  25. doi Differential roles of NMDA Receptor Subtypes NR2A and NR2B in dendritic branch development and requirement of RasGRF1
    Fernando J Sepulveda
    Dept of Physiopathology, Faculty of Biological Sciences, Univ of Concepción, Concepcion, Chile
    J Neurophysiol 103:1758-70. 2010
    ..However, because NMDARs are abundantly present as tri-heteromers (e.g., NR1/NR2A/NR2B) during development, the precise role of the individual subunits NR2A and NR2B in these processes has not been ..
  26. doi [Expression of NR2B in the spinal dorsal horn and dorsal root ganglia in mice with bone cancer pain]
    Rui Han
    Department of Anesthesiology, Third Xiangya Hospital, Central South University, Changsha, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 35:976-82. 2010
    ..of ethology and the immunohistochemistry results of the 2B Subunits of N-methyl-D-aspartate receptors (NR2B) in the spinal cord dorsal horn and dorsal root ganglia (DRG) in mice with bone cancer pain and their correlation, ..
  27. pmc alpha-Isoform of calcium-calmodulin-dependent protein kinase II and postsynaptic density protein 95 differentially regulate synaptic expression of NR2A- and NR2B-containing N-methyl-d-aspartate receptors in hippocampus
    C S Park
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroscience 151:43-55. 2008
    ..be enhanced, we found a subtle, yet preferential displacement of synaptic N-methyl-d-aspartate receptor subunit 2B (NR2B) subunits in lateral regions of the synapse without affecting changes in the localization of N-methyl-d-aspartate ..
  28. doi The pore region of N-methyl-D-aspartate receptors differentially influences stimulation and block by spermine
    Lihua Jin
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
    J Pharmacol Exp Ther 327:68-77. 2008
    The transmembrane and pore-forming regions of N-methyl-D-aspartate receptors containing the NR1 and NR2B subunits were studied by measuring the effects of various NR1 and NR2B mutants on stimulation and block by spermine...
  29. ncbi NMDA receptor subunit gene expression in the rat brain: a quantitative analysis of endogenous mRNA levels of NR1Com, NR2A, NR2B, NR2C, NR2D and NR3A
    D J Goebel
    Department of Anatomy and Cell Biology, Wayne State University, School of Medicine, 540 E Canfield, Detroit, MI 48201, USA
    Brain Res Mol Brain Res 69:164-70. 1999
    ..Pharmacological properties of recombinant human N-methyl-d-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fiberblast cells, Mol. Pharmacol...
  30. pmc Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential
    Laetitia Mony
    Laboratoire de Neurobiologie, Ecole Normale Superieure, CNRS, Paris, France
    Br J Pharmacol 157:1301-17. 2009
    ..The present review focuses on allosteric modulation of NMDARs containing the NR2B subunit...
  31. pmc In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death
    M A Martel
    Centre for Neuroscience Research, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, UK
    Neuroscience 158:334-43. 2009
    It has been suggested that NR2B-containing N-methyl-d-aspartate (NMDA) receptors have a selective tendency to promote pro-death signaling and synaptic depression, compared with the survival promoting, synapse potentiating properties of ..
  32. doi Structural basis of NR2B-selective antagonist recognition by N-methyl-D-aspartate receptors
    Laetitia Mony
    Laboratoire de Neurobiologie, Centre National de Recherche Scientifique CNRS Unité Mixte de Recherche 8544, Ecole Normale Superieure, Paris, France
    Mol Pharmacol 75:60-74. 2009
    ..are ifenprodil and derivatives, compounds that act as noncompetitive inhibitors selective for NMDARs containing the NR2B subunit...
  33. ncbi Deletion of the C-terminal domain of the NR2B subunit alters channel properties and synaptic targeting of N-methyl-D-aspartate receptors in nascent neocortical synapses
    Ralf Mohrmann
    Lehrstuhl fur Zellphysiologie, Ruhr Universitat Bochum, Bochum, Germany
    J Neurosci Res 68:265-75. 2002
    ..To investigate the involvement of the C-terminal domain of the NR2B subunit in regulating channel properties and synaptic localization, we analyzed gene-targeted mice expressing C-..
  34. ncbi Structural characterization of the intermolecular interactions of synapse-associated protein-97 with the NR2B subunit of N-methyl-D-aspartate receptors
    Lei Wang
    Department of Physics, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    J Biol Chem 280:26992-6. 2005
    ..The molecular scaffold/receptor interaction is mediated by the association of the C terminus of the NR2B subunit of the N-methyl-D-aspartate receptor with the PDZ domains of SAP97...
  35. ncbi Development of NR1, NR2A and NR2B mRNA in NR1 immunoreactive cells of rat visual cortex
    Z Cao
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
    Brain Res 868:296-305. 2000
    ..between the sensitive period for monocular deprivation and the expression of rat NMDAR subunits, NR2A and NR2B. In the rat the sensitive period ends sometime after postnatal day 50 (P50)...
  36. pmc Fear memory impairing effects of systemic treatment with the NMDA NR2B subunit antagonist, Ro 25-6981, in mice: attenuation with ageing
    Poonam Mathur
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, NIH, Rockville, MD 20852 9411, USA
    Pharmacol Biochem Behav 91:453-60. 2009
    ..We characterized pre-conditioning systemic treatment of the NR2B subunit-selective antagonist Ro 25-6981 for effects on multi-trial, one-trial and low-shock Pavlovian fear ..
  37. pmc Inhibition of NR2B phosphorylation restores alterations in NMDA receptor expression and improves functional recovery following traumatic brain injury in mice
    Johanna Schumann
    Department of Pharmacology, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel
    J Neurotrauma 25:945-57. 2008
    ..In the hippocampus, the expression of NR1, NR2A, and NR2B subunits as well as the GluR1 subunit of the AMPA receptor (AMPAR) were increased, while in the cortex at the ..
  38. pmc Specific determinants of conantokins that dictate their selectivity for the NR2B subunit of N-methyl-D-aspartate receptors
    Z Sheng
    W M Keck Center for Transgene Research and Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    Neuroscience 170:703-10. 2010
    ..con)-G, a 17-residue peptide, is selective for NMDARs containing the N-methyl-d-aspartate receptor subunit 2 B (NR2B), whereas the homologous peptides, con-T and con-R, show broader selectivity for NR2 subunits...
  39. ncbi Different trends in modulation of NMDAR1 and NMDAR2B gene expression in cultured cortical and hippocampal neurons after lead exposure
    W K Lau
    Department of Biology and Institute for Natural Resources and Environmental Management, Hong Kong Baptist University, Hong Kong, Kowloon Tong, PR China
    Brain Res 932:10-24. 2002
    ..In order to investigate the effects of Pb(2+) on the gene expression of NR1 and NR2B subunits in neurons, primary cell cultures of rat cortical and hippocampal neurons were employed...
  40. doi Forelimb dyskinesia mediated by high-frequency stimulation of the subthalamic nucleus is linked to rapid activation of the NR2B subunit of N-methyl-D-aspartate receptors
    Adrien Quintana
    Institut National de la Sante et de la Recherche Medicale, Unité 836 INSERM U386, Universite Joseph Fourier, Grenoble, France
    Eur J Neurosci 32:423-34. 2010
    ..in glutamatergic neurotransmission as previously reported for L-DOPA-induced dyskinesias, focusing on the role of NR2B-containing N-methyl-D-aspartate receptors (NR2B/NMDARs)...
  41. doi Association analysis of GRIN1 and GRIN2B polymorphisms and Parkinson's disease in a hospital-based case-control study
    Shey Lin Wu
    Department of Neurology, Chang Hua Christian Hospital, Chang Hua, Taiwan
    Neurosci Lett 478:61-5. 2010
    ..78, 95%CI=0.59-1.02, P(trend)=0.073). Our results suggest that polymorphisms in the GRIN1 and GRIN2B genes may serve as potential biomarkers for a reduced risk of PD among the Chinese population in Taiwan...
  42. ncbi [Anti-nMDA receptor encephalitis--clinical manifestations and pathophysiology]
    Takahiro Iizuka
    Department of Neurology, School of Medicine, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa, 228 8555, Japan
    Brain Nerve 60:1047-60. 2008
    ..Two years later, they identified conformal extracellular epitopes present in the NR1/NR2B heteromers of NMDAR, which are expressed in the hippocampus/forebrain...
  43. ncbi Presynaptic NR2B-containing NMDA autoreceptors mediate gluta-matergic synaptic transmission in the rat visual cortex
    Yan Hai Li
    The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi an Jiaotong University, Xi an, Shaanxi 710049, P R China
    Curr Neurovasc Res 6:104-9. 2009
    ..Using a specific antagonist for NR2B-NMDA-Rs, (alphaR,betaS)-alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidinepropanol hydrochloride (Ro ..
  44. ncbi Decrease in N-methyl-D-aspartic acid receptor-NR2B subunit levels by intrathecal short-hairpin RNA blocks group I metabotropic glutamate receptor-mediated hyperalgesia
    Bichoy H Gabra
    Department of Pharmacology and Toxicology, Virginia Commonwealth University Medical Center, P O Box 980613, Richmond, VA 23298 0613
    J Pharmacol Exp Ther 322:186-94. 2007
    ..antagonist at the glycine-binding site of the NMDAR), ifenprodil and Ro 25-6981 (selective antagonists of the NR2B subunit of the NMDAR), bisindolylmaleimide I and Go-7874 [12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-..
  45. doi Chronic unpredictable stress before pregnancy reduce the expression of brain-derived neurotrophic factor and N-methyl-D-aspartate receptor in hippocampus of offspring rats associated with impairment of memory
    Yuejun Huang
    The Department of Pediatrics, The Second Affiliated Hospital of Medical College of Shantou University, North Dongxia Road, 515041, Shantou, Guangdong Province, China
    Neurochem Res 35:1038-49. 2010
    ..well as the expression of brain-derived neurotrophic factor (BDNF), N-methyl-D-aspartate (NMDA) 2A (NR2A) and 2B (NR2B) receptors in the hippocampus of the offspring rats when they were 2 months postnatally...
  46. ncbi Localization of N-methyl-D-aspartate NR2B subunits on primary sensory neurons that give rise to small-caliber sciatic nerve fibers in rats
    Q P Ma
    Department of Pharmacology, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, CM20 2QR, Harlow, UK
    Neuroscience 101:699-707. 2000
    ..and retrograde tracing techniques to investigate the relationship between the N-methyl-D-aspartate receptor NR2B subunits and small-diameter primary afferent dorsal root ganglion neurons that give rise to the sciatic nerve ..
  47. pmc NR2B subunit of the NMDA receptor in the basolateral amygdala is necessary for the acquisition of conditioned defeat in Syrian hamsters
    Diane E Day
    Department of Biology, Georgia State University, Atlanta, GA 30303, USA
    Behav Brain Res 217:55-9. 2011
    ..heteromeric receptor complex, making it difficult to distinguish the relative contributions of either the NR2A or NR2B receptor subtypes on the acquisition of CD...
  48. ncbi Transient down-regulation of NMDA receptor subunit gene expression in the rat retina following NMDA-induced neurotoxicity is attenuated in the presence of the non-competitive NMDA receptor antagonist MK-801
    D J Goebel
    Department of Anatomy and Cell Biology, Wayne State University, School of Medicine, Canfield, Detroit, MI 48201, USA
    Exp Eye Res 72:547-58. 2001
    ..Following NMDA insult, the mRNA levels for NR1(com ), NR2A, NR2B and, to a lesser extent, the NR2C subunit were substantially reduced within 24 hr post-treatment (PT), and remained ..
  49. doi Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation
    Shan Jing Geng
    Neuroscience Research Institute and Department of Neurobiology, Peking University, 38 Xue Yuan Road, Beijing 100191, PR China
    Exp Neurol 222:256-66. 2010
    ..cord BDNF contributes to the development and maintenance of neuropathic pain by activation of the dorsal horn NR2B-containing NMDA (NMDA-2B) receptors, this study was designed to investigate if alterations in BDNF and its TrkB ..
  50. ncbi Differential modulation of Ca2+/calmodulin-dependent protein kinase II activity by regulated interactions with N-methyl-D-aspartate receptor NR2B subunits and alpha-actinin
    A J Robison
    Department of Molecular Physiology and Biophysics, Center for Molecular Neurosciences and The Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    J Biol Chem 280:39316-23. 2005
    ..The NR2B subunit of N-methyl-d-aspartate (NMDA)-type glutamate receptor, densin-180, and alpha-actinin bind comparable, ..
  51. ncbi Contribution of NR2B subunits to synaptic transmission in amygdaloid interneurons
    Csaba Szinyei
    Institute of Physiology, Medical School, Otto von Guericke University, 39120 Magdeburg, Germany
    J Neurosci 23:2549-56. 2003
    ..time course, with both components being significantly reduced by ifenprodil (10 microm), an antagonist of the NR2B subunit of NMDA receptors...
  52. ncbi Laminar distribution of NMDA receptor subunit (NR1, NR2A, NR2B) expression during the critical period in cat visual cortex
    George D Mower
    Department of Anatomical Sciences and Neurobiology, Health Sciences Center, University of Louisville School of Medicine, 500 South Preston St, A Bldg, Rm 902, Louisville, KY 40202, USA
    Brain Res Mol Brain Res 119:19-27. 2003
    ..to determine developmental changes in the laminar distribution of the three major cortical NMDA subunits (NR2A, NR2B, NR1) during the critical period in cat visual cortex...
  53. pmc Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors
    T R Butler
    Department of Psychology, University of Kentucky, Lexington, KY 40536 0509, USA
    Neuroscience 165:525-34. 2010
    ..of mature neuron density (NeuN); microtubule associated protein-2(a,b) density (MAP-2); and NMDA receptor NR1 and NR2B subunit density in the primary cell layers of the dentate gyrus (DG), CA3, and CA1 regions, was conducted...
  54. doi In vivo neurochemical effects of the NR2B selective NMDA receptor antagonist CR 3394 in 6-hydroxydopamine lesioned rats
    Sophie Sarre
    Department of Pharmaceutical Chemistry and Drug Analysis, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Laarbeeklaan 103, B1090 Brussels, Belgium
    Eur J Pharmacol 584:297-305. 2008
    ..N-[2-(3,5-dimethyl-1-adamantyl)ethyl]acetamidine, an adamantane derivative with preferential selectivity for the NR2B subunit of the NMDA receptor, has dopamine releasing properties in vivo...
  55. ncbi Osmotic activation of the hypothalamo-neurohypophysial system reversibly downregulates the NMDA receptor subunit, NR2B, in the supraoptic nucleus of the hypothalamus
    M C Currás-Collazo
    Department of Neuroscience, University of California at Riverside, Riverside, CA 92521, USA
    Brain Res Mol Brain Res 70:187-96. 1999
    ..we examined the effects of osmotic stimulation on the protein expression of the NMDA receptor subunits, NR1 and NR2B, important in binding glycine and glutamate, respectively...
  56. pmc The site specific demethylation in the 5'-regulatory area of NMDA receptor 2B subunit gene associated with CIE-induced up-regulation of transcription
    Mei Qiang
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 5:e8798. 2010
    ..We recently reported that NMDA receptor 2B (NR2B) gene expression was persistently up-regulated following chronic intermittent ethanol (CIE) treatment...
  57. ncbi Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesia
    Wei Guo
    Department of Biomedical Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 24:9161-73. 2004
    Hindpaw inflammation induces tyrosine phosphorylation (tyr-P) of the NMDA receptor (NMDAR) 2B (NR2B) subunit in the rat spinal dorsal horn that is closely related to the initiation and development of hyperalgesia...
  58. ncbi Reversal of cocaine-induced behavioral sensitization and associated phosphorylation of the NR2B and GluR1 subunits of the NMDA and AMPA receptors
    Xiuwu Zhang
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 32:377-87. 2007
    ..changes were associated with parallel alterations in expression levels and/or phosphorylation changes in the NR2B and GluR1 subunits of the respective NMDA and AMPA receptors...
  59. ncbi The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801
    G Rammes
    Clinical Neuropharmacology, Max Planck Institute of Psychiatry, Kraepelinstr 2, 80804 Munich, Germany
    Neuropharmacology 40:749-60. 2001
    ..5.5mM) and Xenopus oocytes (NR1-1a/NR2A assemblies: IC(50) approx. 350 microM, NR1-1a/NR2B: IC(50) approx...
  60. ncbi Interleukin-1 beta released by gp120 drives neural death through tyrosine phosphorylation and trafficking of NMDA receptors
    Barbara Viviani
    Laboratory of Toxicology and Center of Excellence on Neurodegenerative Diseases, Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    J Biol Chem 281:30212-22. 2006
    ..Increased phosphorylation of NR2B Tyr-1472 was observed after 24 h of exposure of neurons to 600 pm gp120...
  61. pmc N-methyl-D-aspartate receptor subunit phenotypes of vagal afferent neurons in nodose ganglia of the rat
    Krzysztof Czaja
    Programs in Neuroscience and Department of Veterinary, Comparative Anatomy, Pharmacology, and Physiology, College of Veterinary Medicine, Washington State University, Pullman, 99163 6520, USA
    J Comp Neurol 496:877-85. 2006
    ..Although NMDA receptor subunits (NR1, NR2B, NR2C, and NR2D) have been linked to distinct neuronal populations in the brain, the NMDA receptor subunit ..
  62. doi Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices
    Gerhard Rammes
    Dept of Anesthesiology, Technische Universitat Munchen, D 81675 Munich, Germany
    Neuropharmacology 60:982-90. 2011
    ..NMDA receptors containing the NR2B subunit have been proposed to play a particularly important role in excitotoxicity, functioning as extracellular "..
  63. pmc Tonic facilitation of glutamate release by presynaptic NR2B-containing NMDA receptors is increased in the entorhinal cortex of chronically epileptic rats
    Jian Yang
    Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, United Kingdom
    J Neurosci 26:406-10. 2006
    ..R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid] and NR2B [(alphaR, betaS)-alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidinepropanol hydrochloride (Ro 25-..
  64. doi Colon mustard oil instillation induced cross-organ reflex sensitization on the pelvic-urethra reflex activity in rats
    Hsien Yu Peng
    Department of Physiology, College of Medicine, Chung Shan Medical University, No 110, Chang Kuo North Rd Section 1, Taichung 40201, Taiwan
    Pain 142:75-88. 2009
    We investigated the participation of cyclin-dependent kinase-5 (Cdk5)-mediated N-methyl-D-aspartate receptor (NMDAR) NR2B subunit phosphorylation in cross-organ reflex sensitization caused by colon irritation...
  65. pmc Molecular determinants of NMDA receptor function in GABAergic neurones of rat forebrain
    T Plant
    I Physiologisches Institut, Universitat des Saarlandes, Homburg, Germany
    J Physiol 499:47-63. 1997
    ..When tested for NR2A-C, all but one neurone were shown to express mRNA for NR2B. The NR2B subunit mRNA was usually detected together with NR2A or NR2C...
  66. pmc Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma
    Josep Dalmau
    Department of Neurology, Division of Neuro Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Neurol 61:25-36. 2007
    ..To report the autoantigens of a new category of treatment-responsive paraneoplastic encephalitis...
  67. pmc EphrinB2 induces tyrosine phosphorylation of NR2B via Src-family kinases during inflammatory hyperalgesia
    S Slack
    Wolfson Centre for Age Related Diseases, Hodgkin Building, Wolfson Wing, King s College London, London SE1 1UL, UK
    Neuroscience 156:175-83. 2008
    ..In particular, EphB receptor activation would induce phosphorylation of the NR2B subunit of the NMDA receptor by a Src family non-receptor tyrosine kinase...
  68. ncbi Pharmacological heterogeneity of NMDA receptors: characterization of NR1a/NR2D heteromers expressed in Xenopus oocytes
    A L Buller
    Department of Pharmacology, University of Nebraska Medical Center, Omaha 68198 6260, USA
    Eur J Pharmacol 320:87-94. 1997
    ..NMDA receptors expressed in Xenopus oocytes was examined and compared to the pharmacology of NR1a/NR2A, NR1a/NR2B and NR1a/NR2C heteromers...
  69. ncbi Developmental changes in localization of NMDA receptor subunits in primary cultures of cortical neurons
    J H Li
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007, USA
    Eur J Neurosci 10:1704-15. 1998
    ..using antibodies against distinct N-methyl-D-aspartic acid (NMDA) receptor subunits, illustrated that the NR2A and NR2B subunit proteins have developmental profiles in cultured cortical neurons similar to those seen in vivo...
  70. ncbi Virally mediated knock-down of NR2 subunits ipsilateral to the deprived eye blocks ocular dominance plasticity
    Zhiping Cao
    Portland VA Medical Center, PO Box 1034 P3ANES, Portland, OR 97239, USA
    Exp Brain Res 177:64-77. 2007
    NMDA receptors (NMDARs) are important in developmental plasticity in the visual cortex. The NR2A and NR2B subunits of this receptor develop with different time courses, suggesting that they play different roles in plasticity...
  71. ncbi Odorant deprivation reversibly modulates transsynaptic changes in the NR2B-mediated CREB pathway in mouse piriform cortex
    Hyun H Kim
    Department of Anatomy and Neurobiology, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 26:9548-59. 2006
    ..Permanent zinc sulfate lesion of the olfactory epithelium resulted in a selective loss of the NMDA receptor NR2B protein and mRNA expression in pyramidal cells in layer IIb of PC after 2-7 d...
  72. pmc The effects of NR2 subunit-dependent NMDA receptor kinetics on synaptic transmission and CaMKII activation
    David M Santucci
    Department of Neurobiology, Duke University Medical Center, Durham, NC, USA
    PLoS Comput Biol 4:e1000208. 2008
    ..Subtypes of the NMDA receptor NR2 subunit are differentially expressed during development; in the forebrain, the NR2B receptor is dominant early in development, and later both NR2A and NR2B are expressed...
  73. ncbi Effects of an anabolic-androgenic steroid on the regulation of the NMDA receptor NR1, NR2A and NR2B subunit mRNAs in brain regions of the male rat
    P Le Greves
    Department of Pharmaceutical Biosciences, Uppsala University
    Neurosci Lett 226:61-4. 1997
    The expression of the N-methyl-D-aspartate (NMDA) receptor subunits NR1, NR2A and NR2B mRNAs was examined in discrete areas of the male rat brain (including hippocampus, hypothalamus, nucleus accumbens and cortex) following 14 days daily ..
  74. ncbi Human immunodeficiency virus (HIV)-induced neurotoxicity: roles for the NMDA receptor subtypes
    Lauren A O'Donnell
    Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 26:981-90. 2006
    ..Furthermore, brain regions enriched in NMDAR-2A (NR2A) and NMDAR-2B (NR2B) subunits, such as the hippocampus, are particularly vulnerable...
  75. pmc In vivo blockade of N-methyl-D-aspartate receptors induces rapid trafficking of NR2B subunits away from synapses and out of spines and terminals in adult cortex
    S Fujisawa
    Center for Neural Science, New York University, 4 Washington Place, Room 809, New York, NY 10003, USA
    Neuroscience 121:51-63. 2003
    ..the role of in vivo synaptic activity upon trafficking of the N-methyl-D-aspartate (NMDA) receptor subunit, NR2B, at mature synapses by electron microscopic immunocytochemistry...
  76. ncbi Role of NR2B-containing N-methyl-D-aspartate receptors in haloperidol-induced c-Fos expression in the striatum and nucleus accumbens
    J Lee
    Department of Psychiatry, Medical Sciences Building, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Neuroscience 122:739-45. 2003
    ..The striatum expresses mainly NR1/NR2A and NR1/NR2B subtypes of NMDA receptors, each having different functional and pharmacological properties...
  77. ncbi Excitatory amino acid receptors of the electrosensory system: the NR1/NR2B N-methyl-D-aspartate receptor
    Erik Harvey-Girard
    Research Institute of the McGill University Health Center, Montreal, Quebec H3G1A4, Canada
    J Neurophysiol 89:822-32. 2003
    The amino acid sequence of the N-methyl-D-aspartate (NMDA) receptor subunit NR2B from the brown ghost knife fish Apteronotus leptorhynchus has been determined and compared with the sequence of the murine NR2B...
  78. ncbi Differential expression of NMDA and AMPA receptor subunits in rat dorsal and ventral hippocampus
    C Pandis
    Physiology Department, Medical School, University of Patras, 26500 Rio, Patras, Greece
    Neuroscience 140:163-75. 2006
    ..1) transverse slices for examining a) the expression of the AMPA (GluRA, GluRB, GluRC) and NMDA (NR1, NR2A, NR2B) subunits mRNA using in situ hybridization, b) the protein expression of NR2A and NR2B subunits using Western ..
  79. ncbi PKC site mutations reveal differential modulation by insulin of NMDA receptors containing NR2A or NR2B subunits
    Michelle L Jones
    Laboratory of Integrative Neuroscience and Laboratory for Molecular Biology, Department of Biological Sciences, University of Illinois at Chicago, 845 W Taylor Street, Chicago, IL 60607, USA
    J Neurochem 92:1431-8. 2005
    ..Previously we identified two sites in the NR2B C-terminus as targets for direct phosphorylation by C-type protein kinases (PKCs)...
  80. ncbi Differential expression of N-methyl-D-aspartate receptor subunit messenger ribonucleic acids and immunoreactivity in the rat neostriatum during postnatal development
    W K Lau
    Department of Biology, Hong Kong Baptist University, 224 Waterloo Road, Kowloon Tong, Hong Kong, PR China
    Neurochem Int 43:47-65. 2003
    ..The levels of NR2B and NR2C mRNAs were low at PND 1 and their levels increased at PND 7 and remained high in adults...
  81. doi Conantokins derived from the Asprella clade impart conRl-B, an N-methyl d-aspartate receptor antagonist with a unique selectivity profile for NR2B subunits
    Konkallu Hanumae Gowd
    Department of Biology, University of Utah, Salt Lake City, UT, USA
    Biochemistry 51:4685-92. 2012
    ..rolani, including conantokin conRl-B that has shown an unprecedented selectivity for blocking NMDARs that contain NR2B subunits. ConRl-B shares only some sequence similarity with the most studied NR2B selective conantokin, conG...
  82. doi N-methyl-D-aspartate receptor 2B subunit (GRIN2B) gene variation is associated with alerting, but not with orienting and conflicting in the Attention Network Test
    Stefanie Schulz
    Institute for Cognitive Neuroscience, Department of Biopsychology, Faculty of Psychology, Ruhr University Bochum, Germany
    Neuropharmacology 63:259-65. 2012
    ..In the present study, the role of variations in GRIN2B, which encodes the NR2B subunit of N-methyl-d-aspartate (NMDA) receptors, was explored with regard to the regulation of arousal and ..
  83. pmc Inhibition of activated NR2B gene- and caspase-3 protein-expression by glutathione following traumatic brain injury in a rat model
    Muhammad Zafrullah Arifin
    Department of Neurosurgery, Faculty of Medicine, Universitas Padjadjaran Dr Hasan Sadikin Hospital, Bandung, Indonesia
    Asian J Neurosurg 6:72-7. 2011
    ..b>NR2B is a glutamate receptor and its activation is caused by TBI increasing a brain cell death, along with caspase-3 as ..
  84. ncbi The effects of exercise intensity on p-NR2B expression in cerebral ischemic rats
    Anjing Zhang
    Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China
    Can J Neurol Sci 39:613-8. 2012
    The current study explored the effects of treadmill exercise intensity on functional recovery and hippocampal phospho-NR2B (p-NR2B) expression in cerebral ischemic rats, induced by permanent middle cerebral artery occlusion (MCAO) surgery.
  85. pmc A genome-wide association study of aging
    Stefan Walter
    Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurobiol Aging 32:2109.e15-28. 2011
    ..These findings indicate that variation in genes involved in neurological processes may be an important factor in regulating aging free of major disease and achieving longevity...
  86. ncbi Changing subunit composition of heteromeric NMDA receptors during development of rat cortex
    M Sheng
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724
    Nature 368:144-7. 1994
    ..exist in rat neocortex as heteromeric complexes of considerable heterogeneity, some containing both NR2A and NR2B subunits...
  87. doi NMDA receptors are involved in upstream of the spinal JNK activation in morphine antinociceptive tolerance
    Rui Xian Guo
    Department of Physiology, Zhongshan Medical College, Sun Yat Sen University, 74, Zhongshan 2nd Road, Guangzhou 510080, PR China
    Neurosci Lett 467:95-9. 2009
    ..The present study investigated the link between the spinal NMDA receptor NR2B subunit and the JNK activation during morphine antinociceptive tolerance in rats...
  88. doi Selective effects of neonatal handling on rat brain N-methyl-D-aspartate receptors
    A Stamatakis
    Biology Biochemistry Lab, Faculty of Nursing, University of Athens, 11527 Athens, Greece
    Neuroscience 164:1457-67. 2009
    ..of two obligatory, channel forming NR1 subunits and two regulatory subunits, usually a combination of NR2A and NR2B. Since the subunit composition of the NMDA receptor affects brain plasticity, in the present study we investigated ..
  89. pmc Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors
    Cara A Mosley
    Department of Chemistry, Emory University, Atlanta, GA, USA
    Bioorg Med Chem 17:6463-80. 2009
    The synthesis and structure-activity relationship analysis of a novel class of amide-based biaryl NR2B-selective NMDA receptor antagonists are presented...
  90. doi Different expression of NR2B and PSD-95 in rat hippocampal subregions during postnatal development
    Li Rong Chang
    Department of Anatomy, Capital Medical University, Beijing 100069, China
    Microsc Res Tech 72:517-24. 2009
    ..In this study, we used immunofluorescent staining to assess NR2B and PSD-95 expressions and the relationship between them in CA1, CA3, and DG of rat hippocampus on different ..
  91. doi Ifenprodil induced antinociception and decreased the expression of NR2B subunits in the dorsal horn after chronic dorsal root ganglia compression in rats
    Wei Zhang
    Department of Anesthesiology, Drum Tower Hospital, Medical Department of Nanjing University, Nanjing 210008, Jiangsu Province, China
    Anesth Analg 108:1015-20. 2009
    ..Ifenprodil is an antagonist selective for N-methyl D-aspartate receptor 2B (NR2B) subunits. Several researches have reported effective analgesia of ifenprodil in animal models of neuropathic pain...
  92. ncbi Characterisation of N-methyl-D-aspartate receptor-specific [(3)H]Ifenprodil binding to recombinant human NR1a/NR2B receptors compared with native receptors in rodent brain membranes
    S Grimwood
    Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, England
    J Neurochem 75:2455-63. 2000
    ..conditions to provide the first detailed characterisation of the pharmacology of the ifenprodil site on NMDA NR1/NR2B receptors, using recombinant human NR1a/NR2B receptors stably expressed in L(tk-) cells, in comparison with rat ..
  93. doi Lack of association of three GRIN2B polymorphisms with bipolar disorder
    Aleksandra Szczepankiewicz
    Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
    World J Biol Psychiatry 10:469-73. 2009
    ..In linkage disequilibrium analysis we did not find linkage between the three polymorphisms of GRIN2B gene. The polymorphisms of GRIN2B gene analysed in this study are not likely to be associated with bipolar disorder...
  94. pmc NR2B-selective conantokin peptide inhibitors of the NMDA receptor display enhanced antinociceptive properties compared to non-selective conantokins
    Cai Xiao
    Institute of Biotechnology, Beijing 100071, China
    Neuropeptides 42:601-9. 2008
    b>NR2B-selective inhibitors show lower side-effects in preclinical pain models than non-selective NMDA receptor (NMDAR) antagonists, but it is unclear whether the improved safety of NR2B-selective inhibitors is due to their subtype ..
  95. pmc Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression
    Anteneh M Feyissa
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Prog Neuropsychopharmacol Biol Psychiatry 33:70-5. 2009
    ..In this study, we examined the expression of NMDA receptor subunits NR1, NR2A, and NR2B as well as PSD-95 in the anterior prefrontal cortex (PFC) using Western blot method...
  96. pmc The expression of NMDA receptor subunit mRNA in human chronic alcoholics
    Justin P Ridge
    SMMS, University of Queensland, Brisbane, Queensland, Australia
    Ann N Y Acad Sci 1139:10-9. 2008
    ..We used real-time RT-PCR normalized to GAPDH to assay NR1, NR2A, and NR2B subunit mRNA in superior frontal and primary motor cortex tissue obtained at autopsy from chronic alcoholics with ..
  97. ncbi Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain
    Lara Fallon
    Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Biol Chem 277:486-91. 2002
    ..These data implicate for the first time a PDZ-mediated interaction between parkin and CASK in neurodegeneration and possibly in ubiquitination of proteins involved in synaptic transmission and plasticity...
  98. ncbi Association analysis for NMDA receptor subunit 2B (GRIN2B) genetic variants and psychopathology and clozapine response in schizophrenia
    C J Hong
    Department of Psychiatry, Veterans General Hospital Taipei, Taiwan, ROC
    Psychiatr Genet 11:219-22. 2001
    ....
  99. ncbi Two N-methyl-D-aspartate receptors in rat dorsal root ganglia with different subunit composition and localization
    Juan Carlos G Marvizon
    Neuroenteric Disease Program, CURE Digestive Diseases Research Center, Department of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 446:325-41. 2002
    ..Western blots indicated that rat dorsal root ganglia (DRG) contain NR1, NR2B, NR2C, and NR2D but not NR2A...
  100. doi Effect of 5-azacytidine on the methylation aspects of NMDA receptor NR2B gene in the cultured cortical neurons of mice
    C R Marutha Ravindran
    Department of Biology, The University of Texas at San Antonio, One University Circle, San Antonio, TX 78249, USA
    Neurochem Res 34:342-50. 2009
    ..cultured cortical neurons of mice causes demethylation of cytosine residues in the CpG island of the NMDA receptor NR2B gene (Marutha Ravindran and Ticku, Mol Brain Res 121:19-27, 2004)...
  101. ncbi Biochemical evidence for the co-association of three N-methyl-D-aspartate (NMDA) R2 subunits in recombinant NMDA receptors
    L M Hawkins
    Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, 29 39 Brunswick Square, London WC1N 1AX, United Kingdom
    J Biol Chem 274:27211-8. 1999
    ..transfected with the NR1-1a and NR2A NMDA receptor subunits in combination with both FLAG- and c-Myc epitope-tagged NR2B subunits...

Research Grants75

  1. MOLECULAR PHARMACOLOGY OF NMDA RECEPTORS
    Keith Williams; Fiscal Year: 1999
    ..Studies of chimeric NR2 subunits will initially involve NR2A and NR2B but will be expanded to include subunits containing portions of NR2C and NR2D...
  2. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2010
    ..NMDA receptors between D1 and D2 MSNs and will test the hypothesis of the involvement of the triheteromeric NR1/NR2B /NR2D receptors...
  3. Role of LGI1 in Autosomal Dominant Lateral Temporal Lobe Epilepsy
    Matthew P Anderson; Fiscal Year: 2010
    ..We examine: 1) presynaptic glutamate release down-regulation and role of Kv1.1 K+ channel activity;2) postsynaptic NR2B NMDA receptor current and synaptic plasticity down-regulation, PSD95-Src complex formation, and the role of Src ..
  4. Structure and Function of NMDA Receptors
    Hiroyasu Furukawa; Fiscal Year: 2010
    ..by the binding of allosteric modulators, including Zn2+, ifenprodil, proton, and polyamines, to the NR1 and NR2B ATDs...
  5. Mechanism of action of novel subunit-selective NMDA receptor modulators
    Stephen F Traynelis; Fiscal Year: 2010
    ..Since its first description, the NR2B-selective NMDA receptor antagonist ifenprodil and its many analogues have been used in a multitude of studies ..
  6. The Role of Gliotransmission in Cerebral Ischemia
    Shinghua Ding; Fiscal Year: 2010
    ..Specifically, we will determine whether astrocytes stimulate the NR2B- containing NMDAR (NR2B-NMDAR)-mediated neuronal excitation after ischemia...
  7. MOLECULAR STUDIES OF BRAIN NMDA RECEPTORS
    R Suzanne Zukin; Fiscal Year: 2007
    ..extrasynaptic (NR1/NR2B) NMDARs in hippocampal neurons...
  8. MOLECULAR STUDIES OF BRAIN NMDA RECEPTORS
    R Suzanne Zukin; Fiscal Year: 2009
    ..extrasynaptic (NR1/NR2B) NMDARs in hippocampal neurons...
  9. Steroids-Functional Modulators of Amino Acid Receptors
    DAVID FARB; Fiscal Year: 2007
    ..NR2A or NR2B confers PS potentiation, whereas NR2C or NR2D confers PS inhibition...
  10. NEOCORTICAL EPILEPSY DURING DEVELOPMENT
    JOHN HABLITZ; Fiscal Year: 2005
    ..We will examine if NR2B subunit containing NMDARs in lesioned cortex confer hyperexcitability through the prolongation of excitatory ..
  11. Role of NMDA receptor subtypes in visual plasticity
    ASHA BHAKAR; Fiscal Year: 2007
    ..NMDARs are a subtype of glutamate receptor and the ratio of synaptic NMDAR subunits, NR2A to NR2B (NR2A/2B ratio) changes in response to visual experience and deprivation...
  12. Estrogen and hippocampal plasticity
    LORI LYNN MCMAHON; Fiscal Year: 2010
    ..E2 increases the magnitude of LTP by increasing the density of silent synapses which express NMDARs containing NR2B subunits;AIM 2 will test the hypothesis that E2 mediated effects on spine density and synaptic function are not ..
  13. Estrogen and hippocampal plasticity
    Lori McMahon; Fiscal Year: 2009
    ..E2 increases the magnitude of LTP by increasing the density of silent synapses which express NMDARs containing NR2B subunits; AIM 2 will test the hypothesis that E2 mediated effects on spine density and synaptic function are not ..
  14. Remodeling Neuronal Chromatin in Mouse Models for Depression
    Schahram Akbarian; Fiscal Year: 2010
    ..This resulted in decreased levels of the NMDA receptor subunit Grin2b (NR2B) in prefrontal cortex and hippocampus...
  15. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2010
    ..NMDA receptors between D1 and D2 MSNs and will test the hypothesis of the involvement of the triheteromeric NR1/NR2B /NR2D receptors...
  16. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2009
    ..NMDA receptors bewteen D1 and D2 MSNs and will test the hypothesis of the involvement of the triheteromeric NR1/NR2B /NR2D receptors...
  17. HMGB1 and Traumatic Brain Injury
    Krishnan M Dhandapani; Fiscal Year: 2010
    ..The incorporation of NR2A and NR2B knockout mice will determine whether individual NR2 subunits contribute to HMGB1 release, brain swelling, and ..
  18. Blood Coagulation Protein - Metal Ion - Lipid Interactions
    Francis Castellino; Fiscal Year: 2009
    ..HEK293 cells and in primary neurons, testing the hypothesis that the downstream neuroprotective effects of NR2B-specific conantokins are achieved by modulation of steps of the the ERK1/2 pathway...
  19. Blood Coagulation Protein - Metal Ion - Lipid Interactions
    Francis J Castellino; Fiscal Year: 2010
    ..HEK293 cells and in primary neurons, testing the hypothesis that the downstream neuroprotective effects of NR2B-specific conantokins are achieved by modulation of steps of the the ERK1/2 pathway...
  20. Role of LGI1 in Autosomal Dominant Lateral Temporal Lobe Epilepsy
    Matthew Anderson; Fiscal Year: 2009
    ..1 K+ channel activity; 2) postsynaptic NR2B NMDA receptor current and synaptic plasticity down-regulation, PSD95-Src complex formation, and the role of Src ..
  21. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2002
    ..The result of this study will reveal how the relative contribution of the NMDA subunit NR1 and NR2B determines the kinetics of NMDA-mediated synaptic currents in developing rat neocortical and cerebellar neurons...
  22. Macrophages, NR2B-containing NMDA Receptors and HIV Dementia
    HUANGUI HANK XIONG; Fiscal Year: 2010
    ..composed, in large part, of NR2A-containing NMDARs (NR2ARs), promote cell survival, whereas extrasynaptic NMDARs, NR2B-containing NMDARs (NR2BRs), induce cell death...
  23. Immunity to brain Ma proteins: A remote effect of cancer
    Josep Dalmau; Fiscal Year: 2007
    ..these patients had antibodies to cell surface antigens (highly enriched in hippocampus), which we identified as the NR2B (and at a lesser degree NR2A) subunits of the NMDA receptor...
  24. HIV Neural Apoptosis: Mechanisms, Pathways & Protection
    Dennis Kolson; Fiscal Year: 2007
    ..Brain regions enriched in NMDAR expressing the NR2A and NR2B subunits, such as the hippocampus, are particularly vulnerable to HIV...
  25. HIV Neural Apoptosis: Mechanisms, Pathways & Protection
    DENNIS LARRY KOLSON; Fiscal Year: 2010
    ..Brain regions enriched in NMDAR expressing the NR2A and NR2B subunits, such as the hippocampus, are particularly vulnerable to HIV...
  26. HIV Neural Apoptosis: Mechanisms, Pathways & Protection
    Dennis Kolson; Fiscal Year: 2009
    ..Brain regions enriched in NMDAR expressing the NR2A and NR2B subunits, such as the hippocampus, are particularly vulnerable to HIV...
  27. Mechanisms of nicotine-induced neuroplasticity
    Katumi Sumikawa; Fiscal Year: 2010
    ..Our study shows that in vivo exposure to nicotine causes the enhancement of NR2B-containing NMDAR-mediated responses via tyrosine phosphorylation, leading to long-lasting long-term potentiation (..
  28. Roles for gliotransmisssion in seizure-related disorders
    Philip G Haydon; Fiscal Year: 2010
    ..follows status epilepticus, and III: Ca2+-dependent gliotransmission induces neuronal death by the activation of NR2B-containing NMDA receptors...
  29. Roles for gliotransmisssion in seizure-related disorders
    Philip Haydon; Fiscal Year: 2007
    ..follows status epilepticus, and III: Ca2+-dependent gliotransmission induces neuronal death by the activation of NR2B-containing NMDA receptors...
  30. Roles for gliotransmisssion in seizure-related disorders
    Philip Haydon; Fiscal Year: 2006
    ..follows status epilepticus, and III: Ca2+-dependent gliotransmission induces neuronal death by the activation of NR2B-containing NMDA receptors...
  31. CONTROL OF GLUTAMATE RECEPTOR ACTIVATION
    Stephen Traynelis; Fiscal Year: 2006
    ..0 (125 nM H+) or 7.4 (50 nM H+) for recombinant NRI/NR2A and NRI/NR2B receptors...