NR1H2

Summary

Gene Symbol: NR1H2
Description: nuclear receptor subfamily 1 group H member 2
Alias: LXR-b, LXRB, NER, NER-I, RIP15, UNR, oxysterols receptor LXR-beta, LX receptor beta, liver X nuclear receptor beta, nuclear orphan receptor LXR-beta, nuclear receptor NER, steroid hormone-nuclear receptor NER, ubiquitously-expressed nuclear receptor
Species: human
Products:     NR1H2

Top Publications

  1. Janowski B, Grogan M, Jones S, Wisely G, Kliewer S, Corey E, et al. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc Natl Acad Sci U S A. 1999;96:266-71 pubmed
    ..These results support the hypothesis that naturally occurring oxysterols are physiological ligands for LXRs and show that a rational, structure-based approach can be used to design potent LXR ligands for pharmacologic use. ..
  2. Blaschke F, Leppanen O, Takata Y, Caglayan E, Liu J, Fishbein M, et al. Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries. Circ Res. 2004;95:e110-23 pubmed
    ..The full text of this article is available online at http://circres.ahajournals.org. ..
  3. Dahlman I, Nilsson M, Jiao H, Hoffstedt J, Lindgren C, Humphreys K, et al. Liver X receptor gene polymorphisms and adipose tissue expression levels in obesity. Pharmacogenet Genomics. 2006;16:881-9 pubmed
    LXRA and LXRB genes regulate adiposity, energy dissipation, as well as glucose and lipid homeostasis in mice. We investigated the LXR genes in human obesity...
  4. Blaschke F, Takata Y, Caglayan E, Collins A, Tontonoz P, Hsueh W, et al. A nuclear receptor corepressor-dependent pathway mediates suppression of cytokine-induced C-reactive protein gene expression by liver X receptor. Circ Res. 2006;99:e88-99 pubmed
    ..Our observations identify a novel mechanism of inflammatory gene regulation by LXR ligands. Thus, inhibition of CRP expression by LXR agonists may provide a promising approach to impact initiation and progression of atherosclerosis. ..
  5. Ghisletti S, Huang W, Ogawa S, Pascual G, Lin M, Willson T, et al. Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. Mol Cell. 2007;25:57-70 pubmed
    ..These studies define parallel but functionally distinct pathways that are utilized by PPARgamma and LXRs to differentially regulate complex programs of gene expression that control immunity and homeostasis. ..
  6. Nilsson M, Dahlman Wright K, Karelmo C, Ebeling M, Gustafsson J, Steffensen K. Elk1 and SRF transcription factors convey basal transcription and mediate glucose response via their binding sites in the human LXRB gene promoter. Nucleic Acids Res. 2007;35:4858-68 pubmed
    The nuclear receptors LXRalpha (NR1H3) and LXRbeta (NR1H2) are attractive drug targets for the treatment of diabetes and cardiovascular disease due to their established role as regulators of cholesterol and lipid metabolism...
  7. Infante J, Rodriguez Rodriguez E, Mateo I, Llorca J, Vázquez Higuera J, Berciano J, et al. Gene-gene interaction between heme oxygenase-1 and liver X receptor-beta and Alzheimer's disease risk. Neurobiol Aging. 2010;31:710-4 pubmed publisher
    ..75) had a higher risk of developing AD than subjects without these risk genotypes. Considering synergistic effects between polymorphisms in cellular cholesterol efflux-related genes may help in determining the risk profile for AD. ..
  8. Dahlman I, Nilsson M, Gu H, Lecoeur C, Efendic S, Ostenson C, et al. Functional and genetic analysis in type 2 diabetes of liver X receptor alleles--a cohort study. BMC Med Genet. 2009;10:27 pubmed publisher
    Liver X receptor alpha (LXRA) and beta (LXRB) regulate glucose and lipid homeostasis in model systems but their importance in human physiology is poorly understood...
  9. Venteclef N, Jakobsson T, Ehrlund A, Damdimopoulos A, Mikkonen L, Ellis E, et al. GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response. Genes Dev. 2010;24:381-95 pubmed publisher

More Information

Publications140 found, 100 shown here

  1. Moslehi R, Signore C, Tamura D, Mills J, DiGiovanna J, Tucker M, et al. Adverse effects of trichothiodystrophy DNA repair and transcription gene disorder on human fetal development. Clin Genet. 2010;77:365-73 pubmed publisher
    ..frequency of 10(-6)) recessive disorder caused by mutations in genes involved in nucleotide excision repair (NER) pathway and in transcription...
  2. Sarasin A, Bounacer A, Lepage F, Schlumberger M, Suarez H. Mechanisms of mutagenesis in mammalian cells. Application to human thyroid tumours. C R Acad Sci III. 1999;322:143-9 pubmed
    ..adducts produced by chemical carcinogens or UV-irradiation are usually repaired by the nucleotide excision repair (NER) pathway which is able to detect structural distortion in the normal double-strand DNA backbone...
  3. Cuce M, Gallo Cantafio M, Siciliano M, Riillo C, Caracciolo D, Scionti F, et al. Trabectedin triggers direct and NK-mediated cytotoxicity in multiple myeloma. J Hematol Oncol. 2019;12:32 pubmed publisher
    ..for the first time, the direct and immune-mediated anti-MM activity of the nucleotide excision repair (NER)-dependent agent trabectedin. Gene-expression profiling (GEP) was carried out with HTA2.0 Affymetrix array...
  4. Khan S, Oh K, Emmert S, Imoto K, Tamura D, DiGiovanna J, et al. XPC initiation codon mutation in xeroderma pigmentosum patients with and without neurological symptoms. DNA Repair (Amst). 2009;8:114-25 pubmed publisher
    ..without neurological abnormalities, respectively, had identical defects in the XPC DNA nucleotide excision repair (NER) gene. Patient XP21BE, a 27-year-old woman, had developmental delay and early onset of sensorineural hearing loss...
  5. Gorgun M, Zhuo M, Englander E. Cisplatin Toxicity in Dorsal Root Ganglion Neurons Is Relieved by Meclizine via Diminution of Mitochondrial Compromise and Improved Clearance of DNA Damage. Mol Neurobiol. 2017;54:7883-7895 pubmed publisher
    ..Crosslinks are repairable primarily via the nucleotide excision repair (NER) pathway, which is present in nuclei but absent from mitochondrial compartment...
  6. Kurihara C, Tanaka T, Yamanouchi D. Hyperglycemia attenuates receptor activator of NF-κB ligand-induced macrophage activation by suppressing insulin signaling. J Surg Res. 2017;214:168-175 pubmed publisher
    ..suppressed by inhibiting mimicking hyperglycemia (HG) through upregulation of glucose-sensing nuclear receptor, Nr1h2. Here in this study, we focused on the role of HG-induced altered glucose uptake on macrophage activation. RAW264...
  7. Ban E, Lye M, Chong P, Yap Y, Lim S, Abdul Rahman H. Haplotype CGC from XPD, hOGG1 and ITGA2 polymorphisms increases the risk of nasopharyngeal carcinoma in Malaysia. PLoS ONE. 2017;12:e0187200 pubmed publisher
    ..XPD gene encodes DNA helicase enzyme that is involved in nucleotide excision repair (NER)...
  8. Santos Escobar F, Leyva Sánchez H, Ramírez Ramírez N, Obregón Herrera A, Pedraza Reyes M. Roles of Bacillus subtilis RecA, Nucleotide Excision Repair, and Translesion Synthesis Polymerases in Counteracting Cr(VI)-Promoted DNA Damage. J Bacteriol. 2019;201: pubmed publisher
    ..subtilis strains deficient in homologous recombination (RecA) and nucleotide excision repair (NER) (UvrA), components of the SOS response, were significantly more sensitive to Cr(VI) treatment than were cells of ..
  9. He Q, Pu J, Yuan A, Lau W, Gao E, Koch W, et al. Activation of liver-X-receptor α but not liver-X-receptor β protects against myocardial ischemia/reperfusion injury. Circ Heart Fail. 2014;7:1032-41 pubmed publisher
    Liver-X-receptors, LXRα (NR1H3) and LXRβ (NR1H2), encode 2 different but highly homologous isoforms of transcription factors belonging to the nuclear receptor superfamily...
  10. Long J, Zhu J, Liu Y, Fu K, Tian Y, Li P, et al. Helicase POLQ-like (HELQ) as a novel indicator of platinum-based chemoresistance for epithelial ovarian cancer. Gynecol Oncol. 2018;149:341-349 pubmed publisher
    ..resistance to cisplatin, DNA repair activity, and expression of DNA repair proteins of Nucleotide excision repair (NER) pathway...
  11. Zhang G, Guan Y, Zhao Y, van der Straaten T, Xiao S, Xue P, et al. ERCC2/XPD Lys751Gln alter DNA repair efficiency of platinum-induced DNA damage through P53 pathway. Chem Biol Interact. 2017;263:55-65 pubmed publisher
    ..The platinum-induced DNA damage is recognized and repaired by the nucleotide excision repair (NER) system of which ERCC2/XPD is a critical enzyme...
  12. Elbialy A, Asakawa S, Watabe S, Kinoshita S. A Zebrafish Acromegaly Model Elevates DNA Damage and Impairs DNA Repair Pathways. Biology (Basel). 2018;7: pubmed publisher
    ..break (DSB), homologous recombination repair (HRR), non-homologous end joining (NHEJ), nucleotide excision repair (NER), and translesion synthesis (TLS)...
  13. Wang Y, Li F, Zhang G, Kang L, Guan H. Ultraviolet-B induces ERCC6 repression in lens epithelium cells of age-related nuclear cataract through coordinated DNA hypermethylation and histone deacetylation. Clin Epigenetics. 2016;8:62 pubmed publisher
    ..factor for pathogenesis of ARNC, is induced by UVB, and is generally resolved by the nucleotide excision repair (NER) repair mechanism...
  14. Yu S, Tang S, Mayer G, Cobb G, Maul J. Interactive effects of ultraviolet-B radiation and pesticide exposure on DNA photo-adduct accumulation and expression of DNA damage and repair genes in Xenopus laevis embryos. Aquat Toxicol. 2015;159:256-66 pubmed publisher
    ..13 genes that are, collectively, involved in stress defense, cell cycle arrest, nucleotide excision repair (NER), base excision repair, mismatch repair, DNA repair regulation, and apoptosis. We exposed X...
  15. Chesner L, Campbell C. A quantitative PCR-based assay reveals that nucleotide excision repair plays a predominant role in the removal of DNA-protein crosslinks from plasmids transfected into mammalian cells. DNA Repair (Amst). 2018;62:18-27 pubmed publisher
    ..as plasmids harboring lesions that are selectively repaired by the base excision or nucleotide excision repair (NER) pathways...
  16. Edifizi D, Schumacher B. Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms. Biomolecules. 2015;5:1855-69 pubmed publisher
    DNA damage causally contributes to aging and cancer. Congenital defects in nucleotide excision repair (NER) lead to distinct cancer-prone and premature aging syndromes...
  17. Mullenders L. DNA damage mediated transcription arrest: Step back to go forward. DNA Repair (Amst). 2015;36:28-35 pubmed publisher
    ..R-loops are processed into DNA single and double strand breaks by NER factors depending on TC-NER factors leading to genome instability...
  18. Conca P, Cafaro G, De Renzo A, Coppola A, Cimino E, Tarantino G. Successful and Safe Long-Term Standard Antiviral Therapy in a Patient with "Explosive" Immune Response in Course of HCV-Related Liver Cirrhosis. Int J Mol Sci. 2015;16:14075-85 pubmed publisher
    ..e., RF beyond three thousand times the upper of normal range (unr), type II cryoglobulinemia with cryocrit 40% and monoclonal gammopathy IgM-k, has been successfully and safely ..
  19. Wang J, Keisala T, Solakivi T, Minasyan A, Kalueff A, Tuohimaa P. Serum cholesterol and expression of ApoAI, LXRbeta and SREBP2 in vitamin D receptor knock-out mice. J Steroid Biochem Mol Biol. 2009;113:222-6 pubmed publisher
    ..Although VDR seems to regulate some of the genes involved in cholesterol metabolism, its role in the regulation of serum cholesterol seems to be minimal...
  20. Riemslagh F, Lans H, Seelaar H, Severijnen L, Melhem S, Vermeulen W, et al. HR23B pathology preferentially co-localizes with p62, pTDP-43 and poly-GA in C9ORF72-linked frontotemporal dementia and amyotrophic lateral sclerosis. Acta Neuropathol Commun. 2019;7:39 pubmed publisher
    ..HR23B binding partners XPC, 20S and ataxin-3, which are involved in nucleotide excision repair (NER) and the ubiquitin-proteasome system (UPS), did not show an aberrant distribution...
  21. Repa J, Li H, Frank Cannon T, Valasek M, Turley S, TANSEY M, et al. Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse. J Neurosci. 2007;27:14470-80 pubmed
    ..Thus, LXR activation resulted in increased cholesterol excretion from the brain, decreased neuroinflammation, and deactivation of microglia to slow neurodegeneration and extend the lifespan of the NPC1 mouse...
  22. Dai Y, Miao Y, Wu W, Li Y, D Errico F, Su W, et al. Ablation of Liver X receptors ? and ? leads to spontaneous peripheral squamous cell lung cancer in mice. Proc Natl Acad Sci U S A. 2016;113:7614-9 pubmed publisher
    ..develops in mice in which the genes for two oxysterol receptors, Liver X Receptor (LXR) ? (Nr1h3) and ? (Nr1h2), are inactivated. By 1 y of age, most of these mice have to be euthanized because of severe dyspnea...
  23. Barnhoorn S, Uittenboogaard L, Jaarsma D, Vermeij W, Tresini M, Weymaere M, et al. Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency. PLoS Genet. 2014;10:e1004686 pubmed publisher
    As part of the Nucleotide Excision Repair (NER) process, the endonuclease XPG is involved in repair of helix-distorting DNA lesions, but the protein has also been implicated in several other DNA repair systems, complicating genotype-..
  24. Kim H, Fan X, Gabbi C, Yakimchuk K, Parini P, Warner M, et al. Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia. Proc Natl Acad Sci U S A. 2008;105:2094-9 pubmed publisher
    ..These include activation of microglia, accumulation of protein aggregates in the cytoplasm of large motor neurons, and depletion of brain cholesterol...
  25. Tomaszowski K, Aasland D, Margison G, Williams E, Pinder S, Modesti M, et al. The bacterial alkyltransferase-like (eATL) protein protects mammalian cells against methylating agent-induced toxicity. DNA Repair (Amst). 2015;28:14-20 pubmed publisher
    ..The Chinese hamster cell line CHO-9, the nucleotide excision repair (NER) deficient derivative 43-3B and the DNA mismatch repair (MMR) impaired derivative Tk22-C1 were transfected with ..
  26. Moschall R, Strauss D, Garcia Bayert M, Gebauer F, Medenbach J. Drosophila Sister of Sex-lethal is a repressor of translation. RNA. 2017;: pubmed publisher
    ..open reading frame, 3' UTR-mediated regulation strictly requires the co-repressor protein Upstream of N-ras (Unr) which is recruited to the msl-2 mRNA by Sxl...
  27. Tanaka T, Takei Y, Yamanouchi D. Hyperglycemia Suppresses Calcium Phosphate-Induced Aneurysm Formation Through Inhibition of Macrophage Activation. J Am Heart Assoc. 2016;5:e003062 pubmed publisher
    ..We hypothesized that high glucose suppresses aneurysm by inhibiting macrophage activation via activation of Nr1h2 (also known as liver X receptor ?), recently characterized as a glucose-sensing nuclear receptor...
  28. Karthikeyan R, Kanimozhi G, Prasad N, Agilan B, Ganesan M, Srithar G. Alpha pinene modulates UVA-induced oxidative stress, DNA damage and apoptosis in human skin epidermal keratinocytes. Life Sci. 2018;212:150-158 pubmed publisher
    ..Modulatory role of AP against UVA-mediated inflammatory markers expression, nucleotide excision repair (NER) proteins and apoptotic markers expression during AP and/or UVA treatment were studied by western blot...
  29. Musich P, Li Z, Zou Y. Xeroderma Pigmentosa Group A (XPA), Nucleotide Excision Repair and Regulation by ATR in Response to Ultraviolet Irradiation. Adv Exp Med Biol. 2017;996:41-54 pubmed publisher
    ..These studies also have served to elucidate the nucleotide excision repair (NER) process, especially the critical role played by the XPA protein...
  30. Guo J, Ito S, Nguyen H, Yamamoto K, Tanoue R, Kunisue T, et al. Effects of prenatal exposure to triclosan on the liver transcriptome in chicken embryos. Toxicol Appl Pharmacol. 2018;347:23-32 pubmed publisher
    ..in relation to these TCS-induced signaling and phenotypes were found, including activated SREBF1, PPARa, LXRa, and LXRb in males and activated GLI2 in females; COUP-TFII was predicted to be suppressed in both genders...
  31. Beresova L, Vesela E, Chamrad I, Voller J, Yamada M, Furst T, et al. Role of DNA Repair Factor Xeroderma Pigmentosum Protein Group C in Response to Replication Stress As Revealed by DNA Fragile Site Affinity Chromatography and Quantitative Proteomics. J Proteome Res. 2016;15:4505-4517 pubmed
    ..XPC is a key factor in the DNA repair pathway known as global genomic nucleotide excision repair (GG-NER), a mechanism whose several components were enriched at the FRA16D fragment in our screen...
  32. Wyatt L, Luz A, Cao X, Maurer L, Blawas A, Aballay A, et al. Effects of methyl and inorganic mercury exposure on genome homeostasis and mitochondrial function in Caenorhabditis elegans. DNA Repair (Amst). 2017;52:31-48 pubmed publisher
    ..Genotoxic outcomes measured included DNA damage, DNA damage repair (nucleotide excision repair, NER; base excision repair, BER), and genomic copy number following MeHg and HgCl2 exposure alone and in ..
  33. Huang Y, Wang X, Niu X, Wang X, Jiang R, Xu T, et al. EZH2 suppresses the nucleotide excision repair in nasopharyngeal carcinoma by silencing XPA gene. Mol Carcinog. 2017;56:447-463 pubmed publisher
    ..XPA plays a pivot role in nucleotide excision repair (NER)...
  34. Weedon Fekjær M, Johnsen G, Anthonisen E, Sugulle M, Nebb H, Duttaroy A, et al. Expression of liver X receptors in pregnancies complicated by preeclampsia. Placenta. 2010;31:818-24 pubmed publisher
    ..Our results suggest a possible role for LXRbeta as a transcriptional regulator in preeclampsia. ..
  35. Gómez Marroquín M, Martin H, Pepper A, Girard M, Kidman A, Vallin C, et al. Stationary-Phase Mutagenesis in Stressed Bacillus subtilis Cells Operates by Mfd-Dependent Mutagenic Pathways. Genes (Basel). 2016;7: pubmed publisher
    ..These results suggest that Mfd promotes mutagenic events that required the participation of NER pathway and PolI...
  36. Portich J, dos Santos R, Kersting N, Jorge K, Casagrande P, Dos Santos Costa G, et al. DNA damage response in patients with pediatric Acute Lymphoid Leukemia during induction therapy. Leuk Res. 2017;54:59-65 pubmed publisher
    ..caused by antitumor therapies evokes different repair mechanisms responses, such as Nucleotide Excision Repair (NER), whose components are being studied as prognosis biomarkers and target therapies...
  37. Shi Q, Boots A, Maas L, Veith C, van Kuijk K, Haenen G, et al. Effect of interleukin (IL)-8 on benzo[a]pyrene metabolism and DNA damage in human lung epithelial cells. Toxicology. 2017;381:64-74 pubmed publisher
    ..B[a]P and B[a]P combined with IL-8, and this might be due to a 3-fold increase in nucleotide excision repair (NER) after IL-8 treatment...
  38. Merolla F, Mascolo M, Ilardi G, Siano M, Russo D, Graziano V, et al. Nucleotide Excision Repair and head and neck cancers. Front Biosci (Landmark Ed). 2016;21:55-69 pubmed
    ..Nucleotide Excision Repair (NER) removes a broad spectrum of DNA damages, mainly bulky DNA lesions...
  39. McAdam E, Brem R, Karran P. Oxidative Stress-Induced Protein Damage Inhibits DNA Repair and Determines Mutation Risk and Therapeutic Efficacy. Mol Cancer Res. 2016;14:612-22 pubmed publisher
    ..Solar UV (wavelength 280-400 nm) is firmly implicated in skin cancer development. Nucleotide excision repair (NER) protects against cancer by removing potentially mutagenic DNA lesions induced by UVB (280-320 nm)...
  40. Kahnamouei S, Narouie B, Sotoudeh M, Mollakouchekian M, Simforoosh N, Ziaee S, et al. Association of XPC Gene Polymorphisms with Prostate Cancer Risk. Clin Lab. 2016;62:1009-15 pubmed
    ..One of the major repair pathways is Nucleotide Excision Repair (NER)...
  41. Lee J, Kim H, Park S, Woo J, Joe E, Jou I. Small heterodimer partner SHP mediates liver X receptor (LXR)-dependent suppression of inflammatory signaling by promoting LXR SUMOylation specifically in astrocytes. Sci Signal. 2016;9:ra78 pubmed publisher
  42. Nagel Z, Kitange G, Gupta S, Joughin B, Chaim I, Mazzucato P, et al. DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme. Cancer Res. 2017;77:198-206 pubmed publisher
    ..DNA methyltransferase (MGMT) activity, small changes in mismatch repair (MMR), nucleotide excision repair (NER), and homologous recombination (HR) capacity contributed to acquired temozolomide resistance in PDX models and led ..
  43. Crichton G, Pyysalo S, Chiu B, Korhonen A. A neural network multi-task learning approach to biomedical named entity recognition. BMC Bioinformatics. 2017;18:368 pubmed publisher
    Named Entity Recognition (NER) is a key task in biomedical text mining. Accurate NER systems require task-specific, manually-annotated datasets, which are expensive to develop and thus limited in size...
  44. Zhang R, Jia M, Xu Y, Qian D, Wang M, Zhu M, et al. An ERCC4 regulatory variant predicts grade-3 or -4 toxicities in patients with advanced non-small cell lung cancer treated by platinum-based therapy. Int J Cancer. 2017;: pubmed publisher
    ..Nucleotide excision repair (NER) pathway is the main mechanism of removing platinum-induced DNA adducts that contribute to the toxicity and outcome ..
  45. Whitney K, Watson M, Goodwin B, Galardi C, Maglich J, Wilson J, et al. Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages. J Biol Chem. 2001;276:43509-15 pubmed
    The nuclear oxysterol receptors LXRalpha (NR1H3) and LXRbeta (NR1H2) coordinately regulate the expression of genes involved in the transport and catabolism of cholesterol...
  46. Walczak R, Joseph S, Laffitte B, Castrillo A, Pei L, Tontonoz P. Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors. J Biol Chem. 2004;279:9905-11 pubmed
    ..These observations identify VEGF as an LXR target gene and point to a previously unrecognized role for LXRs in vascular biology. ..
  47. Ishikawa T, Yuhanna I, Umetani J, Lee W, Korach K, Shaul P, et al. LXR?/estrogen receptor-? signaling in lipid rafts preserves endothelial integrity. J Clin Invest. 2013;123:3488-97 pubmed publisher
    ..These studies demonstrate that LXR? has nonnuclear function in EC caveolae/lipid rafts that entails crosstalk with ER?, which promotes NO production and maintains endothelial monolayer integrity in vivo. ..
  48. Bhasuran B, Murugesan G, Abdulkadhar S, Natarajan J. Stacked ensemble combined with fuzzy matching for biomedical named entity recognition of diseases. J Biomed Inform. 2016;64:1-9 pubmed publisher
    Biomedical Named Entity Recognition (Bio-NER) is the crucial initial step in the information extraction process and a majorly focused research area in biomedical text mining...
  49. He J, Zhu Q, Wani G, Wani A. UV-induced proteolysis of RNA polymerase II is mediated by VCP/p97 segregase and timely orchestration by Cockayne syndrome B protein. Oncotarget. 2017;8:11004-11019 pubmed publisher
    RNA polymerase II (RNAPII) acts as a damage sensor for transcription-coupled nucleotide excision repair (TC-NER) and undergoes proteolytic clearance from damaged chromatin by the ubiquitin-proteasome system (UPS)...
  50. Owiti N, Lopez C, Singh S, Stephenson A, Kim N. Def1 and Dst1 play distinct roles in repair of AP lesions in highly transcribed genomic regions. DNA Repair (Amst). 2017;55:31-39 pubmed publisher
    ..We have demonstrated that transcription-coupled nucleotide excision repair (NER) pathway can functionally replace BER to repair those AP sites located on the transcribed strand much like the ..
  51. Zhang W, Shi E, Zhao Y, Yang B. Modulation effect of double strand DNA on the self-assembly of N-terminal domain of Euplotes octocarinatus centrin. J Inorg Biochem. 2018;180:15-25 pubmed publisher
    ..proteins, which can behave as a part of damage detector initiated the initiation of nucleotide excision repair (NER)...
  52. Rodriguez Rodriguez E, Llorca J, Mateo I, Infante J, Sánchez Quintana C, Garcia Gorostiaga I, et al. No association of genetic variants of liver X receptor-beta with Alzheimer's disease risk. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:650-3 pubmed
    ..The current study does not demonstrate an association between LXRbeta genotypes or haplotypes and AD, neither in the total sample nor when the populations were stratified for the presence or absence of the APOE epsilon4 allele. ..
  53. Zhou Z, Humphryes N, van Eijk P, Waters R, Yu S, Kraehenbuehl R, et al. UV induced ubiquitination of the yeast Rad4-Rad23 complex promotes survival by regulating cellular dNTP pools. Nucleic Acids Res. 2015;43:7360-70 pubmed publisher
    ..We demonstrate that this regulatory mechanism, which is dependent on the ubiquitination of Rad4 by the GG-NER E3 ligase, promotes UV survival in yeast cells...
  54. Kim M, Joo E, Lee S, Lee D, Srinivasan S, Jung H. Complete genome sequence of Hymenobacter sp. DG25B, a novel bacterium with gamma-radiation resistance isolated from soil in South Korea. J Biotechnol. 2016;217:98-9 pubmed publisher
    ..gamma ray irradiated soil and contains the genomic features of enzymes involved in the nucleotide excision repair (NER) pathway that protect the damaged DNA...
  55. Malottki K, Popat S, Deeks J, Riley R, Nicholson A, Billingham L. Problems of variable biomarker evaluation in stratified medicine research--A case study of ERCC1 in non-small-cell lung cancer. Lung Cancer. 2016;92:1-7 pubmed publisher
    ..chain reaction (nine studies), immunohistochemistry (five studies) and other methods (multiple methods-two studies, NER polymorphism-one study). In five studies ERCC1 use was planned, but not undertaken...
  56. Delespierre T, Denormandie P, Bar Hen A, Josseran L. Empirical advances with text mining of electronic health records. BMC Med Inform Decis Mak. 2017;17:127 pubmed publisher
    ..a normalized physiotherapy problem list, text mining through information extraction (IE), named entity recognition (NER) and data mining (DM) can provide a real advantage to describe health care, adding new medical material and helping ..
  57. Lin S, Lei K, Du W, Yang L, Shi H, Gao Y, et al. Enhancement of oxaliplatin sensitivity in human colorectal cancer by hypericin mediated photodynamic therapy via ROS-related mechanism. Int J Biochem Cell Biol. 2016;71:24-34 pubmed publisher
    ..and down-regulated the expression of ERCC1 and XPF, two critical enzymes involved in nucleotide excision repair (NER) pathway. GSH monoethyl ester (GSH-EE) antagonized HY-PDT-induced ROS and repressed sensitization to platinum...
  58. Zhang X, Crawford E, Blomquist T, Khuder S, Yeo J, Levin A, et al. Haplotype and diplotype analyses of variation in ERCC5 transcription cis-regulation in normal bronchial epithelial cells. Physiol Genomics. 2016;48:537-43 pubmed publisher
    ..alter ERCC5 regulation, and that C allele at SNP rs17655 downregulates ERCC5 Variation in ERCC5 transcript abundance associated with allelic variation at these SNPs could result in variation in NER function in NBEC and lung cancer risk.
  59. Sidorenko J, Jatsenko T, Kivisaar M. Ongoing evolution of Pseudomonas aeruginosa PAO1 sublines complicates studies of DNA damage repair and tolerance. Mutat Res. 2017;797-799:26-37 pubmed publisher
    ..Moreover, the functions of specialized DNA polymerase IV and nucleotide excision repair (NER) in 4-NQO-induced DNA damage tolerance appeared to be masked in MPAO1, while were easily detectable in other ..
  60. Buñay J, Larriba E, Moreno R, del Mazo J. Chronic low-dose exposure to a mixture of environmental endocrine disruptors induces microRNAs/isomiRs deregulation in mouse concomitant with intratesticular estradiol reduction. Sci Rep. 2017;7:3373 pubmed publisher
    ..analysis showed altered spermatogenesis, germ cell apoptosis and negative correlation of miR-18a-5p with Nr1h2 involved in the deregulation of the steroidogenesis pathway...
  61. Bobin Dubigeon C, Chauvin A, Brillaud Meflah V, Boiffard F, Joalland M, Bard J. Liver X Receptor (LXR)-regulated Genes of Cholesterol Trafficking and Breast Cancer Severity. Anticancer Res. 2017;37:5495-5498 pubmed
    Liver X receptor [LXR; nuclear receptor subfamily 1, group H, member 2 (NR1H2, alias LXRB)] can inhibit proliferation and induce apoptosis of cancer cells. Its relationship with disease severity is not known.
  62. Lewinski N, Jiménez I, McInnes B. An annotated corpus with nanomedicine and pharmacokinetic parameters. Int J Nanomedicine. 2017;12:7519-7527 pubmed publisher
    ..the use of the corpus by evaluating two state-of-the-art named entity extraction systems, OpenNLP and Stanford NER. The annotated corpus is available open source and, based on these results, guidelines and suggestions for future ..
  63. Nilsson M, Stulnig T, Lin C, Yeo A, Nowotny P, Liu E, et al. Liver X receptors regulate adrenal steroidogenesis and hypothalamic-pituitary-adrenal feedback. Mol Endocrinol. 2007;21:126-37 pubmed
    The nuclear hormone receptors liver X receptor alpha (LXRalpha) (NR1H3) and LXRbeta (NR1H2) are established regulators of cholesterol, lipid, and glucose metabolism and are attractive drug targets for the treatment of diabetes and ..
  64. Marwarha G, Rhen T, Schommer T, Ghribi O. The oxysterol 27-hydroxycholesterol regulates ?-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors--relevance to Parkinson's disease. J Neurochem. 2011;119:1119-36 pubmed publisher
    ..Concomitant activation of ER? and inhibition of LXR? prevent 27-OHC effects and may therefore reduce the progression of Parkinson's disease by precluding TH reduction and ?-synuclein accumulation. ..
  65. Courtaut F, Derangère V, Chevriaux A, Ladoire S, Cotte A, Arnould L, et al. Liver X receptor ligand cytotoxicity in colon cancer cells and not in normal colon epithelial cells depends on LXRβ subcellular localization. Oncotarget. 2015;6:26651-62 pubmed publisher
    ..This study strengthens the hypothesis that LXRβ could be a promising target in cancer therapy. ..
  66. Sin Y, Tanaka K, Saijo M. The C-terminal Region and SUMOylation of Cockayne Syndrome Group B Protein Play Critical Roles in Transcription-coupled Nucleotide Excision Repair. J Biol Chem. 2016;291:1387-97 pubmed publisher
    ..CS) is a recessive disorder that results in deficiencies in transcription-coupled nucleotide excision repair (TC-NER), a subpathway of nucleotide excision repair, and cells from CS patients exhibit hypersensitivity to UV light...
  67. Murata Y, Osakabe M. Photo-enzymatic repair of UVB-induced DNA damage in the two-spotted spider mite Tetranychus urticae. Exp Appl Acarol. 2017;71:15-34 pubmed publisher
    ..XPA is a core factor in nucleotide excision repair (NER), which is a repair system unrelated to photo energy...
  68. Bokharaeian B, Diaz A, Taghizadeh N, Chitsaz H, Chavoshinejad R. SNPPhenA: a corpus for extracting ranked associations of single-nucleotide polymorphisms and phenotypes from literature. J Biomed Semantics. 2017;8:14 pubmed publisher
    ..They include automatic Named Entity Recognition (NER) followed by the manual annotation of SNP and phenotype names, annotation of the SNP-phenotype associations and ..
  69. Van Bostelen I, Tijsterman M. Combined loss of three DNA damage response pathways renders C. elegans intolerant to light. DNA Repair (Amst). 2017;54:55-62 pubmed publisher
    ..C. elegans mutants that lack nucleotide excision repair (NER), translesion synthesis (TLS) and alternative end joining (altEJ) grow undisturbed in the dark, but become sterile ..
  70. Guintini L, Charton R, Peyresaubes F, Thoma F, Conconi A. Nucleosome positioning, nucleotide excision repair and photoreactivation in Saccharomyces cerevisiae. DNA Repair (Amst). 2015;36:98-104 pubmed publisher
    ..Since CPDs are removed by nucleotide excision repair (NER) and photolyase repair, it is of paramount importance to understand how DNA damage and repair are tempered by the ..
  71. Liu X, Gao J, Xia Q, Lu T, Wang F. Increased mortality and aggravation of heart failure in liver X receptor-α knockout mice after myocardial infarction. Heart Vessels. 2016;31:1370-9 pubmed publisher
    Liver X receptors, LXRα (NR1H3) and LXRβ (NR1H2), are best known as nuclear oxysterol receptors and physiological master regulators of lipid and cholesterol metabolism...
  72. Rajput P, Pandey V, Kumar V. Stimulation of ribosomal RNA gene promoter by transcription factor Sp1 involves active DNA demethylation by Gadd45-NER pathway. Biochim Biophys Acta. 2016;1859:953-63 pubmed publisher
    ..More importantly, Sp1 also orchestrated the site-specific binding of Gadd45a-nucleotide excision repair (NER) complex resulting in active demethylation and transcriptional activation of rDNA...
  73. Yang Y, He S, Wang Q, Li F, Kwak M, Chen S, et al. Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase. Mol Cell. 2016;62:507-19 pubmed publisher
    UV-induced DNA damage, a major risk factor for skin cancers, is primarily repaired by nucleotide excision repair (NER). UV radiation resistance-associated gene (UVRAG) is a tumor suppressor involved in autophagy...
  74. Hemmateenejad B, Mehdipour A, Deeb O, Sanchooli M, Miri R. Toward an Optimal Approach for Variable Selection in Counter-Propagation Neural Networks: Modeling Protein-Tyrosine Kinase Inhibitory of Flavanoids Using Substituent Electronic Descriptors. Mol Inform. 2011;30:939-49 pubmed publisher
    ..algorithms including F score-based ranking, eigenvalue ranking of PCs obtained from data set, Non-Error-Rate (NER) ranking of both descriptors and PCs, and 3-way handling of data, Parallel Factor Analysis (PARAFAC), was evaluated ..
  75. Bhat A, Qin Z, Wang G, Chen W, Xiao W. Rev7, the regulatory subunit of Polζ, undergoes UV-induced and Cul4-dependent degradation. FEBS J. 2017;284:1790-1803 pubmed publisher
    ..We also show that the nucleotide excision repair (NER) pathway protein HR23B physically interacts and colocalizes with Rev7 in the nuclear foci after UV irradiation and ..
  76. Jarrett S, Carter K, Shelton B, D Orazio J. The melanocortin signaling cAMP axis accelerates repair and reduces mutagenesis of platinum-induced DNA damage. Sci Rep. 2017;7:11708 pubmed publisher
    ..damage was dependent on PKA-mediated phosphorylation of ATR on S435 which promoted ATR's interaction with the key NER factor xeroderma pigmentosum A (XPA) and facilitated recruitment of an XPA-ATR-pS435 complex to sites of cisplatin ..
  77. Kostiv U, Lobaz V, Kucka J, Svec P, Sedlacek O, Hruby M, et al. A simple neridronate-based surface coating strategy for upconversion nanoparticles: highly colloidally stable 125I-radiolabeled NaYF4:Yb3+/Er3+@PEG nanoparticles for multimodal in vivo tissue imaging. Nanoscale. 2017;9:16680-16688 pubmed publisher
    ..buffered saline (PBS), they were modified by using in-house synthesized poly(ethylene glycol)-neridronate (PEG-Ner), a bisphosponate...
  78. Shi E, Zhang W, Zhao Y, Yang B. Modulation of XPC peptide on binding Tb3+ to Euplotes octocarinatus centrin. Metallomics. 2017;9:1796-1808 pubmed publisher
    ..Xeroderma pigmentosum group C protein (XPC), a dominant component of the nuclear excision repair (NER) pathway, is a critical target protein of centrins...
  79. Le Beau M, Song C, Davis E, Hiipakka R, Kokontis J, Liao S. Assignment of the human ubiquitous receptor gene (UNR) to 19q13.3 using fluorescence in situ hybridization. Genomics. 1995;26:166-8 pubmed
  80. Huang W, Ghisletti S, Saijo K, Gandhi M, Aouadi M, Tesz G, et al. Coronin 2A mediates actin-dependent de-repression of inflammatory response genes. Nature. 2011;470:414-8 pubmed publisher
  81. Yoon C, Kwon Y, Lee S, Park Y, Lee S, Park M. Activation of liver X receptors suppresses inflammatory gene expressions and transcriptional corepressor clearance in rheumatoid arthritis fibroblast like synoviocytes. J Clin Immunol. 2013;33:190-9 pubmed publisher
    ..These data suggest that LXR activation can be used as a therapeutic approach to reduce the synovial inflammation in RA. ..
  82. Hanusova V, Caltová K, Svobodová H, Ambroz M, Skarka A, Murínová N, et al. The effects of ?-caryophyllene oxide and trans-nerolidol on the efficacy of doxorubicin in breast cancer cells and breast tumor-bearing mice. Biomed Pharmacother. 2017;95:828-836 pubmed publisher
    ..g. sesquiterpenes. In our previous study, sesquiterpenes ?-caryophyllene oxide (CAO) and trans-nerolidol (NER) improved the anti-proliferative effect of doxorubicin (DOX) in intestinal cancer cell lines...
  83. Han C, Zhao R, Kroger J, He J, Wani G, Wang Q, et al. UV radiation-induced SUMOylation of DDB2 regulates nucleotide excision repair. Carcinogenesis. 2017;38:976-985 pubmed publisher
    Subunit 2 of DNA damage-binding protein complex (DDB2) is an early sensor of nucleotide excision repair (NER) pathway for eliminating DNA damage induced by UV radiation (UVR) and cisplatin treatments of mammalian cells...
  84. Huuskonen J, Vishnu M, Fielding P, Fielding C. Activation of ATP-binding cassette transporter A1 transcription by chromatin remodeling complex. Arterioscler Thromb Vasc Biol. 2005;25:1180-5 pubmed
    ..In this study, we investigated the activation of ABCA1 by brahma-related gene 1 (BRG-1) and brahma, members of the SWI/SNF (mating type switching/sucrose nonfermenting) chromatin remodeling complex...
  85. Rigamonti E, Helin L, Lestavel S, Mutka A, Lepore M, Fontaine C, et al. Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages. Circ Res. 2005;97:682-9 pubmed
  86. Delvecchio C, Bilan P, Radford K, Stephen J, Trigatti B, Cox G, et al. Liver X receptor stimulates cholesterol efflux and inhibits expression of proinflammatory mediators in human airway smooth muscle cells. Mol Endocrinol. 2007;21:1324-34 pubmed
    ..Our findings reveal biological roles for LXR in ASM cells and suggest that modulation of LXR activity offers prospects for new therapeutic approaches in the treatment of asthma and other inflammatory respiratory diseases...
  87. Schmuth M, Jiang Y, Dubrac S, Elias P, Feingold K. Thematic review series: skin lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology. J Lipid Res. 2008;49:499-509 pubmed publisher
    ..Because of their broad profile of beneficial effects on skin homeostasis, PPAR and LXR have great potential to serve as drug targets for common skin diseases such as psoriasis, atopic dermatitis, and skin cancer. ..
  88. Mouzat K, Mercier E, Polge A, Evrard A, Baron S, Balducchi J, et al. A common polymorphism in NR1H2 (LXRbeta) is associated with preeclampsia. BMC Med Genet. 2011;12:145 pubmed publisher
    ..Liver X receptors alpha (NR1H3, also known as LXRalpha) and beta (NR1H2, also known as LXRbeta) play a key role in lipid metabolism...
  89. Noghero A, Perino A, Seano G, Saglio E, Lo Sasso G, Veglio F, et al. Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2. Arterioscler Thromb Vasc Biol. 2012;32:2280-8 pubmed publisher
    ..In the endothelium, perturbations of cell cholesterol have an impact on fundamental processes. We, therefore, assessed the effects of LXR activation on endothelial functions related to angiogenesis in vitro and in vivo...
  90. Kim J, Mouw K, Polak P, Braunstein L, Kamburov A, Kwiatkowski D, et al. Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors. Nat Genet. 2016;48:600-606 pubmed publisher
    ..however, a specific mutational signature associated with somatic alterations in the nucleotide- excision repair (NER) pathway has not yet been identified...
  91. Le H, Tran M, Dang T, Ha Q, Collier N. Sieve-based coreference resolution enhances semi-supervised learning model for chemical-induced disease relation extraction. Database (Oxford). 2016;2016: pubmed publisher
    ..DNER) phase, our system employed joint inference (decoding) with a perceptron-based named entity recognizer (NER) and a back-off model with Semantic Supervised Indexing and Skip-gram for named entity normalization...
  92. Rasouly A, Pani B, Nudler E. A Magic Spot in Genome Maintenance. Trends Genet. 2017;33:58-67 pubmed publisher
    Nucleotide excision repair (NER) is the key DNA repair system that eliminates the majority of DNA helix-distorting lesions...