Gene Symbol: NR1
Description: glutamate ionotropic receptor NMDA type subunit 1
Alias: GluN1, MRD8, NDHMSD, NDHMSR, NMD-R1, NMDA1, NMDAR1, NR1, glutamate receptor ionotropic, NMDA 1, N-methyl-D-aspartate receptor channel, subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1, glutamate [NMDA] receptor subunit zeta-1, glutamate receptor, ionotropic, N-methyl D-aspartate 1
Species: human
Products:     NR1

Top Publications

  1. Galehdari H, Pooryasin A, Foroughmand A, Daneshmand S, Saadat M. Association between the G1001C polymorphism in the GRIN1 gene promoter and schizophrenia in the Iranian population. J Mol Neurosci. 2009;38:178-81 pubmed publisher
    ..12, 95% confidence interval (CI) 1.34-3.48, P = 0.001 and CC genotype: OR = 29.10, 95% CI 3.40-565.78, P < 0.001). Furthermore, the C allele is significantly associated with an increasing risk of schizophrenia. ..
  2. Wu S, Wang W, Shyu H, Ho Y, Shieh J, Fu Y, et al. Association analysis of GRIN1 and GRIN2B polymorphisms and Parkinson's disease in a hospital-based case-control study. Neurosci Lett. 2010;478:61-5 pubmed publisher
    ..78, 95%CI=0.59-1.02, P(trend)=0.073). Our results suggest that polymorphisms in the GRIN1 and GRIN2B genes may serve as potential biomarkers for a reduced risk of PD among the Chinese population in Taiwan. ..
  3. Ding Y, Zhang Y, He B, Yue W, Zhang D, Zou L. A possible association of responsiveness to adrenocorticotropic hormone with specific GRIN1 haplotypes in infantile spasms. Dev Med Child Neurol. 2010;52:1028-32 pubmed publisher
    ..G protein-regulated inducer of neurite outgrowth 1 (GRIN1, also known as N-methyl-D-aspartate receptor 1, NMDAR1), a glutamate receptor, is the main component of functional N-methyl-D-aspartic acid receptors that are involved ..
  4. Hahn C, Wang H, Cho D, Talbot K, Gur R, Berrettini W, et al. Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia. Nat Med. 2006;12:824-8 pubmed
    ..Therefore, these findings suggest that enhanced NRG1 signaling may contribute to NMDA hypofunction in schizophrenia. ..
  5. Mori F, Ribolsi M, Kusayanagi H, Siracusano A, Mantovani V, Marasco E, et al. Genetic variants of the NMDA receptor influence cortical excitability and plasticity in humans. J Neurophysiol. 2011;106:1637-43 pubmed publisher
    ..magnetic stimulations of the motor cortex in 77 healthy subjects carrying specific allelic variants of the NR1 subunit gene (GRIN1 rs4880213 and rs6293) or of the NR2B subunit gene (GRIN2B rs7301328, rs3764028, and rs1805247)...
  6. Das S, Sasaki Y, Rothe T, Premkumar L, Takasu M, Crandall J, et al. Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Nature. 1998;393:377-81 pubmed
    ..It is currently believed that the NMDA receptor (NMDAR) is a heteromultimeric channel comprising the ubiquitous NR1 subunit and at least one regionally localized NR2 subunit...
  7. Haughey N, Nath A, Mattson M, Slevin J, Geiger J. HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity. J Neurochem. 2001;78:457-67 pubmed
    ..Together, these findings suggest that NMDA receptors play an important role in Tat neurotoxicity and the mechanisms identified may provide additional therapeutic targets for the treatment of HIV-1 associated dementia. ..
  8. Williams N, Bowen T, Spurlock G, Norton N, Williams H, Hoogendoorn B, et al. Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor. Mol Psychiatry. 2002;7:508-14 pubmed
    ..2). These SNPs will therefore be suitable for studying neuropsychiatric phenotypes that are putatively related to NMDA dysfunction. Pooled analysis provided no support for association between any of the GRIN genes and schizophrenia. ..
  9. Mundo E, Tharmalingham S, Neves Pereira M, Dalton E, Macciardi F, Parikh S, et al. Evidence that the N-methyl-D-aspartate subunit 1 receptor gene (GRIN1) confers susceptibility to bipolar disorder. Mol Psychiatry. 2003;8:241-5 pubmed
    ..The role of the gene variants in predicting the response to mood stabilizers in BP should also be investigated. ..

More Information

Publications118 found, 100 shown here

  1. Qin S, Zhao X, Pan Y, Liu J, Feng G, Fu J, et al. An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray. Eur J Hum Genet. 2005;13:807-14 pubmed
    ..analysis of the NMDA receptors in the Chinese population, we examined 16 reported SNPs across the NMDA receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B), five of which were identified in the Chinese population...
  2. Pilowsky L, Bressan R, Stone J, Erlandsson K, Mulligan R, Krystal J, et al. First in vivo evidence of an NMDA receptor deficit in medication-free schizophrenic patients. Mol Psychiatry. 2006;11:118-9 pubmed
  3. Miglio G, Varsaldi F, Lombardi G. Human T lymphocytes express N-methyl-D-aspartate receptors functionally active in controlling T cell activation. Biochem Biophys Res Commun. 2005;338:1875-83 pubmed
    ..showed that human resting peripheral blood lymphocytes (PBL) and Jurkat T cells express genes encoding for both NR1 and NR2B subunits: phytohemagglutinin (PHA)-activated PBL also expresses both these genes and the NR2A and NR2D ..
  4. Eugenin E, King J, Nath A, Calderon T, Zukin R, Bennett M, et al. HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes. Proc Natl Acad Sci U S A. 2007;104:3438-43 pubmed
    ..These findings implicate the complex in HIV-induced neuronal apoptosis and suggest therapeutic targets for intervention in the pathogenesis of NeuroAIDS. ..
  5. Georgi A, Jamra R, Klein K, Villela A, Schumacher J, Becker T, et al. Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sample. Psychiatr Genet. 2007;17:308-10 pubmed
    ..Although significances did not withstand correction for multiple testing, the results of our exploratory analysis warrant further studies on GRIN1 and schizophrenia. ..
  6. Shin A, Thayer S. Human immunodeficiency virus-1 protein Tat induces excitotoxic loss of presynaptic terminals in hippocampal cultures. Mol Cell Neurosci. 2013;54:22-9 pubmed publisher
    ..Understanding the dynamics of synaptic changes in response to HIV infection of the CNS may lead to the design of improved pharmacotherapies for HAND patients. ..
  7. Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, et al. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science. 1992;256:1217-21 pubmed
    ..than 20% sequence identity, to other excitatory amino acid receptor subunits, including the NMDA receptor subunit NMDAR1 (NR1)...
  8. Eugenin E, D Aversa T, Lopez L, Calderon T, Berman J. MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis. J Neurochem. 2003;85:1299-311 pubmed
    ..treatment of mixed cultures for 24 h resulted in increased extracellular glutamate ([Glu]e) and NMDA receptor 1 (NMDAR1) expression, potential contributors to apoptosis...
  9. Zhao X, Li H, Shi Y, Tang R, Chen W, Liu J, et al. Significant association between the genetic variations in the 5' end of the N-methyl-D-aspartate receptor subunit gene GRIN1 and schizophrenia. Biol Psychiatry. 2006;59:747-53 pubmed
    ..Hence, the SNP is a potential candidate in altering risk for schizophrenia and worthy of further replication and functional study. ..
  10. Gu J, Chen J, Yang N, Hou X, Wang J, Tan X, et al. Combination of Ligusticum chuanxiong and Radix Paeoniae ameliorate focal cerebral ischemic in MCAO rats via endoplasmic reticulum stress-dependent apoptotic signaling pathway. J Ethnopharmacol. 2016;187:313-24 pubmed publisher
    ..PCR (Q-PCR) were applied to examine vascular endothelial growth factor (VEGF) and N-methyl-d-aspartate receptors (NMDAR1) mRNA levels...
  11. Preciados M, Yoo C, Roy D. Estrogenic Endocrine Disrupting Chemicals Influencing NRF1 Regulated Gene Networks in the Development of Complex Human Brain Diseases. Int J Mol Sci. 2016;17: pubmed
  12. Zhou X, Yang H, Song X, Wang J, Shen L, Wang J. Central blockade of the AT1 receptor attenuates pressor effects via reduction of glutamate release and downregulation of NMDA/AMPA receptors in the rostral ventrolateral medulla of rats with stress-induced hypertension. Hypertens Res. 2019;: pubmed publisher
    ..HR), plasma norepinephrine (NE), glutamate, and the expression of N-methyl-D-aspartic acid (NMDA) receptor subunit NR1, and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors in the RVLM increased in the SIH group...
  13. Iyaswamy A, Kammella A, Thavasimuthu C, Wankupar W, Dapkupar W, Shanmugam S, et al. Oxidative stress evoked damages leading to attenuated memory and inhibition of NMDAR-CaMKII-ERK/CREB signalling on consumption of aspartame in rat model. J Food Drug Anal. 2018;26:903-916 pubmed publisher
    ..The animal brain homogenate also revealed the decrease in the phosphorylation of NMDAR1-CaMKII-ERK/CREB signalling pathway, which well documents the inhibition of phosphorylation leads to the ..
  14. Ma S, Zhang Y, Li X, Zhang H, Jia Y. Analgesic effect of Chinese herbal formula Hua-Jian-Ba-Du ointment on visceral pain in mice induced by acetic acid. Integr Cancer Ther. 2015;14:282-90 pubmed publisher
    ..N-methyl-D-aspartic acid receptor (NMDAR1) and c-fos expressions in both rostral ventromedial medulla (RVM) and spinal dorsal horn were determined by ..
  15. Chapp A, Gui L, Huber M, Liu J, Larson R, Zhu J, et al. Sympathoexcitation and pressor responses induced by ethanol in the central nucleus of amygdala involves activation of NMDA receptors in rats. Am J Physiol Heart Circ Physiol. 2014;307:H701-9 pubmed publisher
    ..Double labeling of immune fluorescence showed NMDA NR1 receptor expression in CeA neurons projecting to the RVLM...
  16. Wang X, Yu H, You J, Wang C, Feng C, Liu Z, et al. Memantine can improve chronic ethanol exposure-induced spatial memory impairment in male C57BL/6 mice by reducing hippocampal apoptosis. Toxicology. 2018;406-407:21-32 pubmed publisher
    ..the expression of cleaved caspase-3 and calcium-related proteins, including N-methyl-d-aspartic acid receptor 1 (NR1), 1,4,5-trisphosphate receptor 1 (IP3R1), and sarco/endoplasmic reticulum calcium adenosine triphosphatase 1 (..
  17. Wang C, Zhang X, Liu F, Paule M, Slikker W. Anesthetic-induced oxidative stress and potential protection. ScientificWorldJournal. 2010;10:1473-82 pubmed publisher
    ..agonists cause neuronal cell death are still not completely understood, up-regulation of the NMDA receptor subunit NR1 may be an initiative factor in neuronal cell death...
  18. Cui W, Liu R, Jin H, Lv P, Sun Y, Men X, et al. pH gradient difference around ischemic brain tissue can serve as a trigger for delivering polyethylene glycol-conjugated urokinase nanogels. J Control Release. 2016;225:53-63 pubmed publisher
    ..Moreover, the expression of both NMDAR1 (P<0.001) and Caspase9 (P=0.013) in PEG-UK-treated rats was reduced...
  19. Yawalkar R, Changotra H, Gupta G. Protective influences of N-acetylcysteine against alcohol abstinence-induced depression by regulating biochemical and GRIN2A, GRIN2B gene expression of NMDA receptor signaling pathway in rats. Neurochem Int. 2018;118:73-81 pubmed publisher
  20. Kapolowicz M, Thompson L. Acute high-intensity noise induces rapid Arc protein expression but fails to rapidly change GAD expression in amygdala and hippocampus of rats: Effects of treatment with D-cycloserine. Hear Res. 2016;342:69-79 pubmed publisher
    ..Finally, the ability of D-cycloserine (DCS; an NMDA-receptor NR1 partial agonist) to reduce or prevent the noise trauma-related plastic changes in the biomarker, Arc, was tested...
  21. Liu J, Wu S, Zhang H, Kuang F. Inhibition of MyD88 Signaling Skews Microglia/Macrophage Polarization and Attenuates Neuronal Apoptosis in the Hippocampus After Status Epilepticus in Mice. Neurotherapeutics. 2018;15:1093-1111 pubmed publisher
    ..MyD88 inhibition also augmented glutamate transporter 1 expression and reduced N-methyl-D-aspartate receptor NR1 subunit expression in the hippocampus to protect pyramidal neurons from apoptosis...
  22. Carr H, Alexander T, Groves T, Kiffer F, Wang J, PRICE E, et al. Early effects of 16O radiation on neuronal morphology and cognition in a murine model. Life Sci Space Res (Amst). 2018;17:63-73 pubmed publisher
    ..Exposure to 16O significantly reduced the expression of Nr1 and GluR1 in the hippocampus and modulated spine morphology in the dentate gyrus and cornu Ammon 1 within the ..
  23. Gonzalez B, Torres O, Jayanthi S, Gomez N, Sosa M, Bernardi A, et al. The effects of single-dose injections of modafinil and methamphetamine on epigenetic and functional markers in the mouse medial prefrontal cortex: potential role of dopamine receptors. Prog Neuropsychopharmacol Biol Psychiatry. 2019;88:222-234 pubmed publisher
    ..the protein levels of acetylated histone H3 (H3ac) and H4ac, deacetylases HDAC1 and HDAC2, and of the NMDA subunit GluN1 in the medial PFC (mPFC) of mice euthanized 1 h after drug administration...
  24. Wang H, Huang F, Hu Z, Zhang W, Qiao X, Huang Y, et al. Early-Life Social Isolation-Induced Depressive-Like Behavior in Rats Results in Microglial Activation and Neuronal Histone Methylation that Are Mitigated by Minocycline. Neurotox Res. 2017;31:505-520 pubmed publisher
    ..ESI also decreased expression of hippocampal NMDA receptor subunits, NR1, and AMPA receptor subunits, GluR1 and GluR2, which are involved in synaptic plasticity, but it did not affect ..
  25. Mizuki D, Matsumoto K, Tanaka K, Thi Le X, Fujiwara H, Ishikawa T, et al. Antidepressant-like effect of Butea superba in mice exposed to chronic mild stress and its possible mechanism of action. J Ethnopharmacol. 2014;156:16-25 pubmed publisher
    ..AMP-responsive element binding protein (CREB) and a phosphorylated form of N-methyl-d-aspartate receptor subunit NR1, synaptic plasticity-related signaling proteins...
  26. Słoniecka M, Le Roux S, Boman P, Byström B, Zhou Q, Danielson P. Expression Profiles of Neuropeptides, Neurotransmitters, and Their Receptors in Human Keratocytes In Vitro and In Situ. PLoS ONE. 2015;10:e0134157 pubmed publisher
    ..NK-2R, receptor D2, choline acetyl transferase (ChAT), M3, M4 and M5 muscarinic ACh receptors, glutamate, and NMDAR1, but not catecholamine synthesizing enzyme or the α1 and β2 adrenoreceptors, nor M1 receptor...
  27. Sung C, Wen Z, Feng C, Chen C, Huang S, Chen N, et al. Potentiation of spinal glutamatergic response in the neuron-glia interactions underlies the intrathecal IL-1?-induced thermal hyperalgesia in rats. CNS Neurosci Ther. 2017;23:580-589 pubmed publisher
    ..IL-1? increased phosphorylation of NR-1 (p-NR1) subunit of N-methyl-D-aspartate receptors in neurons and microglia, reduced glutamate transporters (GTs; glutamate/..
  28. Lannuzel A, Lledo P, Lamghitnia H, Vincent J, Tardieu M. HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons. Eur J Neurosci. 1995;7:2285-93 pubmed
    ..The neurotoxicity of picomolar doses of gp120 and gp160 cultures was estimated by immunofluorescence and colorimetric assay. Treatment of cultures with AP5 or nifedipine reduced gp120-induced toxicity by 70 and ..
  29. Dean B, Gibbons A, Boer S, Uezato A, Meador Woodruff J, Scarr E, et al. Changes in cortical N-methyl-D-aspartate receptors and post-synaptic density protein 95 in schizophrenia, mood disorders and suicide. Aust N Z J Psychiatry. 2016;50:275-83 pubmed publisher
    ..These data suggest that differences in cortical NMDAR expression and post-synaptic density protein 95 are present in psychiatric disorders and suicide completion and may contribute to different responses to ketamine. ..
  30. Vandenberghe F, Guidi M, Choong E, von Gunten A, Conus P, Csajka C, et al. Genetics-Based Population Pharmacokinetics and Pharmacodynamics of Risperidone in a Psychiatric Cohort. Clin Pharmacokinet. 2015;54:1259-72 pubmed publisher
    ..150 psychiatric patients (178 observations) treated with risperidone were genotyped for common polymorphisms in NR1/2, POR, PPARα, ABCB1, CYP2D6 and CYP3A genes...
  31. Anderson E, Reeves T, Kapernaros K, Neubert J, Caudle R. Phosphorylation of the N-methyl-d-aspartate receptor is increased in the nucleus accumbens during both acute and extended morphine withdrawal. J Pharmacol Exp Ther. 2015;355:496-505 pubmed publisher
    ..We discovered an increase in phosphorylation of serine 897 in the NR1 subunit of the NMDA receptor (pNR1) during acute morphine withdrawal...
  32. Isaza C, Henao J, Velez J, Rodríguez M, Sierra J, Beltrán L, et al. [Evaluation of the Methadone Maintenance Program of the Risaralda Mental Hospital]. Rev Colomb Psiquiatr. 2014;43:96-105 pubmed publisher
  33. Liu M, Kay J, Shen S, Qiao L. Endogenous BDNF augments NMDA receptor phosphorylation in the spinal cord via PLCγ, PKC, and PI3K/Akt pathways during colitis. J Neuroinflammation. 2015;12:151 pubmed publisher properties, and its activity is modulated by phosphorylation of its subunits including the NMDA receptor 1 (NR1)...
  34. Wang J, Xu W, Shao J, He Z, Ding Z, Huang J, et al. miR-219-5p targets CaMKIIγ to attenuate morphine tolerance in rats. Oncotarget. 2017;8:28203-28214 pubmed publisher
    ..Furthermore, we found that lentiviral-mediated miR-219-5p decreased the expression of NMDA receptor subunit 1 (NR1), leading to attenuation of morphine tolerance...
  35. Liu S, Liu W, Liu Y, Dong H, Henkemeyer M, Xiong L, et al. Blocking EphB1 receptor forward signaling in spinal cord relieves bone cancer pain and rescues analgesic effect of morphine treatment in rodents. Cancer Res. 2011;71:4392-402 pubmed publisher
    ..bone cancer pain behaviors and the associated induction of c-Fos and activation of astrocytes and microglial cells, NR1 and NR2B receptors, Src within the N-methyl-D-aspartate receptor complex, and the subsequent Ca(2+)-dependent ..
  36. Jones G, Soden M, Knakal C, Lee H, Chung A, Merriam E, et al. A genetic link between discriminative fear coding by the lateral amygdala, dopamine, and fear generalization. elife. 2015;4: pubmed publisher
    ..Here, we utilized mice with a selective genetic inactivation functional NMDARs in dopamine neurons (DAT-NR1 KO mice) combined with behavior, in vivo electrophysiology, and ex vivo electrophysiology in LA neurons to ..
  37. Tachibana M, Shinohara M, Yamazaki Y, Liu C, Rogers J, Bu G, et al. Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1. Exp Neurol. 2016;277:1-9 pubmed publisher
    ..While levels of PSD95, glutamate receptor 1 (GluR1), and N-methyl-d-aspartate receptor NR1 subunit (NR1), which are key postsynaptic proteins that regulate synaptic plasticity, were decreased with aging, ..
  38. Mohammed C, Rhee H, Phee B, Kim K, Kim H, Lee H, et al. miR-204 downregulates EphB2 in aging mouse hippocampal neurons. Aging Cell. 2016;15:380-8 pubmed publisher
    ..of synaptic plasticity in hippocampal neurons, in part by regulating the surface expression of the NMDA receptor NR1 subunit. We found that EphB2 is a direct target of miR-204 among miRNAs that were upregulated with age...
  39. Bonavia R, Bajetto A, Barbero S, Albini A, Noonan D, Schettini G. HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons. Biochem Biophys Res Commun. 2001;288:301-8 pubmed
  40. Cheng J, Giguère P, Schmerberg C, Pogorelov V, Rodriguiz R, Huang X, et al. Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models. J Med Chem. 2016;59:578-91 pubmed publisher
    ..prepulse inhibition, it induced cognitive improvements in the novel object recognition memory test in NR1-KD animals, and it produced very little catalepsy relative to haloperidol...
  41. Escamilla Ramírez A, Garcia E, Palencia Hernández G, Colín González A, Galvan Arzate S, Tunez I, et al. URB597 and the Cannabinoid WIN55,212-2 Reduce Behavioral and Neurochemical Deficits Induced by MPTP in Mice: Possible Role of Redox Modulation and NMDA Receptors. Neurotox Res. 2017;31:532-544 pubmed publisher
    ..the striatal protein levels of tyrosine hydroxylase, and increased the striatal protein content of the subunit 1 (NR1) of the N-methyl-D-aspartate receptor (NMDAr). Both URB597 (0.3 mg/kg, i.p...
  42. Sheng M, Cummings J, Roldan L, Jan Y, Jan L. Changing subunit composition of heteromeric NMDA receptors during development of rat cortex. Nature. 1994;368:144-7 pubmed
    ..Several subunits of the NMDA receptor have been cloned: these are NMDAR1 (NR1), and NMDAR2A, 2B, 2C and 2D (NR2A-D)...
  43. Chen Y, Yang W, Li X, Yang H, Xu Z, Yu S. α-Synuclein-induced internalization of NMDA receptors in hippocampal neurons is associated with reduced inward current and Ca(2+) influx upon NMDA stimulation. Neuroscience. 2015;300:297-306 pubmed publisher
    ..In both cases, NMDA receptor NR1 subunits on the cell surface were reduced while the total amount of NR1 was unchanged, indicating an ..
  44. Wang Y, Rao W, Zhang C, Liu M, Han F, Yao L, et al. Scaffolding protein Homer1a protects against NMDA-induced neuronal injury. Cell Death Dis. 2015;6:e1843 pubmed publisher
    ..we found that Homer1a functionally regulated NMDAR channel properties in neurons, but did not regulate recombinant NR1/NR2B receptors in HEK293 cells...
  45. Coronel M, Raggio M, Adler N, De Nicola A, Labombarda F, González S. Progesterone modulates pro-inflammatory cytokine expression profile after spinal cord injury: Implications for neuropathic pain. J Neuroimmunol. 2016;292:85-92 pubmed publisher
    ..spinal expression of IL-1β, its receptors (IL-1RI and IL-1RII) and antagonist (IL-1ra), IL-6 and TNFα, and NR1 subunit of NMDAR...
  46. Chaudhary S, Kaushik M, Kukreti R, Kukreti S. Structural switch from a multistranded G-quadruplex to single strands as a consequence of point mutation in the promoter of the human GRIN1 gene. Mol Biosyst. 2017;13:1805-1816 pubmed publisher
    ..One such gene is GRIN1 encoding the NR1 subunit of the N-methyl-d-aspartate receptor (NMDA)...
  47. Estrada Rojo F, Morales Gomez J, Coballase Urrutia E, Martínez Vargas M, Navarro L. Diurnal variation of NMDA receptor expression in the rat cerebral cortex is associated with traumatic brain injury damage. BMC Res Notes. 2018;11:150 pubmed publisher
    ..We also found that motor cortex N-methyl-D-aspartate receptor subunit NR1 expression exhibited diurnal variation in both control and traumatic brain injury-subjected rats...
  48. Xin K, Hamajima K, Hattori S, Cao X, Kawamoto S, Okuda K. Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system. AIDS Res Hum Retroviruses. 1999;15:1461-7 pubmed
    ..These data suggest that HIV-1 gp120 may directly bind to the NMDA receptor. This evidence enhances our understanding of the mechanism of HIV-1-induced neuronal damage in AIDS patients. ..
  49. Xie P, Kranzler H, Yang C, Zhao H, Farrer L, Gelernter J. Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder. Biol Psychiatry. 2013;74:656-63 pubmed publisher
    ..Genome-wide association study analyses restricted to trauma-exposed individuals yielded very similar results. This study identified TLL1 as a new susceptibility gene for PTSD. ..
  50. Yin H, Wang W, Yu W, Li J, Feng N, Wang L, et al. Changes in Synaptic Plasticity and Glutamate Receptors in Type 2 Diabetic KK-Ay Mice. J Alzheimers Dis. 2017;57:1207-1220 pubmed publisher
    ..The expression levels of NR1, NR2A, and NR2B subunits of N-methyl-d-aspartate receptors (NMDARs) were unchanged while the Tyr-dependent ..
  51. Cho Y, Kim H, Kim W, Chung S, Kim Y, Cho I, et al. Trafficking patterns of NMDA and GABAA receptors in a Mg2+-free cultured hippocampal neuron model of status epilepticus. Epilepsy Res. 2017;136:143-148 pubmed publisher
    ..Biotinylation assay and immunofluorescence staining for GABAR ?2,3 and NMDAR NR1 subunits were performed to quantify and visualize surface GABARs and NMDARs, respectively...
  52. Rodríguez Muñoz M, Cortés Montero E, Pozo Rodrigálvarez A, Sánchez Blázquez P, Garzón Niño J. The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders. Oncotarget. 2015;6:35458-77 pubmed publisher
    ..It was observed that HINT1 protein binds to GPCRs and NMDAR NR1 subunits in a calcium-independent manner, whereas σ1R binding to these proteins increases in the presence of ..
  53. Xi Y, Zhang D, Ding J, Yu H, Yuan L, Ma W, et al. Genistein Inhibits Aβ25-35-Induced Synaptic Toxicity and Regulates CaMKII/CREB Pathway in SH-SY5Y Cells. Cell Mol Neurobiol. 2016;36:1151-9 pubmed publisher
    ..In addition, the down-regulation of NR1 and NR2B induced by Aβ25-35 which are subunits of N-methyl-D-aspartate receptor also could be antagonized by pre-..
  54. Sajjad J, Felice V, Golubeva A, Cryan J, O Mahony S. Sex-dependent activity of the spinal excitatory amino acid transporter: Role of estrous cycle. Neuroscience. 2016;333:311-9 pubmed publisher
    ..The gene expression of EAATs, glutamate receptor subunits NR1 and NR2B and the estrogen receptors ERα & ERβ in the spinal cord were also analyzed...
  55. Zarić M, Drakulic D, Stojanovic I, Mitrović N, Grković I, Martinovic J. Regional-specific effects of cerebral ischemia/reperfusion and dehydroepiandrosterone on synaptic NMDAR/PSD-95 complex in male Wistar rats. Brain Res. 2018;1688:73-80 pubmed publisher
    ..e. signs of neuronal damage in CA1 area was accompanied with hippocampal vGluT1, NR1, NR2B enhancement and PSD-95 decrement, while histological changes observed in layer III were associated with ..
  56. Parkitna J, Solecki W, Gołembiowska K, Tokarski K, Kubik J, Gołda S, et al. Glutamate input to noradrenergic neurons plays an essential role in the development of morphine dependence and psychomotor sensitization. Int J Neuropsychopharmacol. 2012;15:1457-71 pubmed publisher
    ..drug-induced behaviours, we generated a Cre/loxP mouse model in which the essential glutamate NMDA receptor subunit NR1 is ablated in cells expressing dopamine ?-hydroxylase (Dbh)...
  57. Arboleya S, Clemente A, Deng S, Bedmar M, Salvador I, Herbera P, et al. Anti-NMDAR antibodies in new-onset psychosis. Positive results in an HIV-infected patient. Brain Behav Immun. 2016;56:56-60 pubmed publisher
    ..Our goal was to evaluate the prevalence of IgG antibodies against the NMDAR NR1 subunit (NMDAR-Abs) along with five additional NSAs in 61 first psychotic episode patients and 47 matched controls...
  58. Fan C, Qiao Y, Tang M. Notoginsenoside R1 attenuates high glucose-induced endothelial damage in rat retinal capillary endothelial cells by modulating the intracellular redox state. Drug Des Devel Ther. 2017;11:3343-3354 pubmed publisher
    The aim of this study was to examine whether Notoginsenoside R1 (NR1) attenuates high glucose-induced cell damage in rat retinal capillary endothelial cells (RCECs) and to explore the mechanisms involved...
  59. Kenny A, Cousins S, Pinho L, Stephenson F. The integrity of the glycine co-agonist binding site of N-methyl-D-aspartate receptors is a functional quality control checkpoint for cell surface delivery. J Biol Chem. 2009;284:324-33 pubmed publisher
    ..Point mutations in the glycine binding domain of the NR1-1a subunit were generated: D732A, a mutation that results in an approximately 3 x 10(4) decrease in glycine binding ..
  60. Mantuano E, Lam M, Shibayama M, Campana W, Gonias S. The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration. J Cell Sci. 2015;128:3478-88 pubmed publisher
    ..The NR1 (encoded by GRIN1) and NR2b (encoded by GRIN2B) NMDA-R subunits were expressed by cultured Schwann cells and ..
  61. Mullier B, Wolff C, Sands Z, Ghisdal P, Muglia P, Kaminski R, et al. GRIN2B gain of function mutations are sensitive to radiprodil, a negative allosteric modulator of GluN2B-containing NMDA receptors. Neuropharmacology. 2017;123:322-331 pubmed publisher
    ..Consequently, our data suggest that radiprodil may be a valuable therapeutic option for treatment of pediatric epileptic encephalopathies associated with GRIN2B mutations. ..
  62. Kobayashi M, Nishioka K, Takanashi M, Hattori A, Shojima Y, Hayashida A, et al. Anti-NMDA receptor encephalitis due to large-cell neuroendocrine carcinoma of the uterus. J Neurol Sci. 2017;383:72-74 pubmed publisher
    ..The cerebrospinal fluid tested positive for anti-NMDAR antibodies (encoding the NR1 subunit). The patient was diagnosed with paraneoplastic limbic encephalitis due to uterine cancer...
  63. Funk G, Johnson S, Smith J, Dong X, Lai J, Feldman J. Functional respiratory rhythm generating networks in neonatal mice lacking NMDAR1 gene. J Neurophysiol. 1997;78:1414-20 pubmed
    ..generation by comparing the responsiveness of control mice and mutant mice lacking the NMDA receptor R1 subunit (NMDAR1) gene to glutamate receptor agonists and antagonists and comparing endogenous respiratory-related oscillations ..
  64. Rao J, Harry G, Rapoport S, Kim H. Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients. Mol Psychiatry. 2010;15:384-92 pubmed publisher
    ..The changes may account for reported evidence of disease progression in BD and be a target for future therapy. ..
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    ..GluR1/GluR2 expression were significantly reduced in seipin-nKO mice, whereas the NMDA-induced current (INMDA) and NR1/NR2 expression were not altered...
  66. Toggas S, Masliah E, Mucke L. Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine. Brain Res. 1996;706:303-7 pubmed
    ..They also suggest that clinically tolerated NMDA receptor antagonists may be useful in the prevention of neuronal damage in HIV-1-infected patients. ..
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    ..Interestingly, targeted expression of a carboxy-terminally truncated form of EphB2 rescued the EphB2 null phenotype, indicating that EphB2 kinase signaling is not required for these EphB2-mediated functions. ..
  68. Roginski R, Lau C, Santoiemma P, Weaver S, Du P, Soteropoulos P, et al. The human GCOM1 complex gene interacts with the NMDA receptor and internexin-alpha. Gene. 2018;648:42-53 pubmed publisher
    ..We showed that Gcom15 interacts with the NR1 subunit of the NMDA receptor by co-expression in heterologous cells, in which we observed bi-directional co-..
  69. Corasaniti M, Melino G, Navarra M, Garaci E, Finazzi Agro A, Nistico G. Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase. Neurodegeneration. 1995;4:315-21 pubmed
    ..1-10 microM). In conclusion, the present data suggest that death of human CHP100 neuroblastoma cells in culture produced by gp120 involves NO and PGE2 production. ..
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    ..In addition, NMDA spikes may serve as a powerful mechanism for modification of the cortical network by inducing long-term strengthening of co-activated neighbouring inputs. ..
  71. Self R, Mulholland P, Nath A, Harris B, Prendergast M. The human immunodeficiency virus type-1 transcription factor Tat produces elevations in intracellular Ca2+ that require function of an N-methyl-D-aspartate receptor polyamine-sensitive site. Brain Res. 2004;995:39-45 pubmed
    ..Polyamine-sensitive portions of this receptor may then represent novel therapeutic targets in the pharmacologic treatment of HAD-related neurotoxicity. ..
  72. Fischer M, William T, Helmbold P, Wohlrab J, Marsch W. Expression of epidermal N-methyl-D-aspartate receptors (NMDAR1) depends on formation of the granular layer--analysis in diseases with parakeratotic cornification. Arch Dermatol Res. 2004;296:157-62 pubmed
    ..The distribution of NMDAR1 was compared to the immunohistochemical expression of filaggrin...
  73. Xu H, Bae M, Tovar Y Romo L, Patel N, Bandaru V, Pomerantz D, et al. The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains. J Neurosci. 2011;31:17074-90 pubmed publisher
    ..was activated that accelerated the forward traffic of NMDA receptors by a PKA-dependent phosphorylation of the NR1 C-terminal serine 897 (masks an ER retention signal), followed by a PKC-dependent phosphorylation of serine 896 (..
  74. Kaniaková M, Krausova B, Vyklický V, Korinek M, Lichnerova K, Vyklicky L, et al. Key amino acid residues within the third membrane domains of NR1 and NR2 subunits contribute to the regulation of the surface delivery of N-methyl-D-aspartate receptors. J Biol Chem. 2012;287:26423-34 pubmed publisher
    ..The functional NMDA receptors, heterotetramers composed mainly of two NR1 and two NR2 subunits, likely pass endoplasmic reticulum quality control before they are released from the ..
  75. Castillo Gomez E, Oliveira B, Tapken D, Bertrand S, Klein Schmidt C, Pan H, et al. All naturally occurring autoantibodies against the NMDA receptor subunit NR1 have pathogenic potential irrespective of epitope and immunoglobulin class. Mol Psychiatry. 2017;22:1776-1784 pubmed publisher
    Autoantibodies of the IgG class against N-methyl-d-aspartate-receptor subunit NR1 (NMDAR1) were first described in anti-NMDAR encephalitis and seen as disease indicators...
  76. Tang Y, Wang X, Zhang S, Duan S, Qing W, Chen G, et al. Pre-existing weakness is critical for the occurrence of postoperative cognitive dysfunction in mice of the same age. PLoS ONE. 2017;12:e0182471 pubmed publisher
    ..were collected to detect the levels of neuroinflammation, synaptophysin and NMDA receptor subunits NR2A, NR2B and NR1 (by western blot), and oxidative stress (by Dihydroethidium)...
  77. Rong X, Xiong Z, Cao B, Chen J, Li M, Li Z. Case report of anti-N-methyl-D-aspartate receptor encephalitis in a middle-aged woman with a long history of major depressive disorder. BMC Psychiatry. 2017;17:320 pubmed publisher
    Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disease involving antibodies against the NR1 subunits of NMDARs...
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    ..the neonatal C3H/HeN male mice exposed to DE and DE-SOAs, the mRNA expression levels of the NMDA receptor subunits (NR1, NR2B), proinflammatory cytokines, tumor necrosis factor-? and cyclooxygenase-2, oxidative stress marker, heme ..
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    ..We propose that haploinsufficiency of NPAS3 contributes to the cause of mental illness in this family...
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    ..Using quantitative reverse transcriptase-polymerase chain reaction and western blotting, we found NR1 expression begins low prenatally, peaks in adolescence, yet remains high throughout life, suggesting lifelong ..
  82. Mashkina A, Cizkova D, Vanicky I, Boldyrev A. NMDA receptors are expressed in lymphocytes activated both in vitro and in vivo. Cell Mol Neurobiol. 2010;30:901-7 pubmed publisher
    ..We suggest that expression of NMDA receptors in lymphocytes is regulated by central nervous system, which controls the inflammation process. ..
  83. Liu Y, Li C. Inhibition of N-methyl-D-aspartate-activated current by bis(7)-tacrine in HEK-293 cells expressing NR1/NR2A or NR1/NR2B receptors. J Huazhong Univ Sci Technolog Med Sci. 2012;32:793-797 pubmed publisher
    In normal rat forebrain, the NR1/NR2A and NR1/NR2B dimmers are the main constitutional forms of NMDA receptors...
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    ..the localization of LRFN2 at synapses of cerebellar and hippocampal rat neurons, often associated with the NR1 subunit of N-methyl-D-aspartate receptors (NMDARs)...
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    ..Here we show that 3 NMDAR subunits, NR1, NR2A, and NR2B, are expressed in the human cerebral cortex during the second trimester of gestation, a period of ..
  86. Lesept F, Chevilley A, Jezequel J, Ladépêche L, Macrez R, Aimable M, et al. Tissue-type plasminogen activator controls neuronal death by raising surface dynamics of extrasynaptic NMDA receptors. Cell Death Dis. 2016;7:e2466 pubmed publisher
    ..Each obligatory subunit of NMDARs (GluN1 and GluN2) contains two extracellular clamshell-like domains with an agonist-binding domain and a distal N-..
  87. Marins F, Iddings J, Fontes M, Filosa J. Evidence that remodeling of insular cortex neurovascular unit contributes to hypertension-related sympathoexcitation. Physiol Rep. 2017;5: pubmed publisher
    ..Alterations in NVU structure were investigated by immunofluorescence for NMDA receptors (NR1), blood vessels (70 kDa FITC-dextran), astrocytes (GFAP), and microglia (Iba1)...
  88. Ujita W, Kohyama Koganeya A, Endo N, Saito T, Oyama H. Mice lacking a functional NMDA receptor exhibit social subordination in a group-housed environment. FEBS J. 2017;: pubmed publisher
    ..Our findings suggested that Grin1 plays an important role in determining social dominance. This article is protected by copyright. All rights reserved...
  89. Gonzalez B, Jayanthi S, Gomez N, Torres O, Sosa M, Bernardi A, et al. Repeated methamphetamine and modafinil induce differential cognitive effects and specific histone acetylation and DNA methylation profiles in the mouse medial prefrontal cortex. Prog Neuropsychopharmacol Biol Psychiatry. 2018;82:1-11 pubmed publisher
    ..The lack of similar epigenetic effects of chronic modafinil administration supports this notion. ..
  90. Wyszynski M, Lin J, Rao A, Nigh E, Beggs A, Craig A, et al. Competitive binding of alpha-actinin and calmodulin to the NMDA receptor. Nature. 1997;385:439-42 pubmed
    ..alpha-Actinin-2 binds by its central rod domain to the cytoplasmic tail of both NR1 and NR2B subunits of the NMDA receptor, and can be immunoprecipitated with NMDA receptors and PSD-95 from rat brain...
  91. Tingley W, Ehlers M, Kameyama K, Doherty C, Ptak J, Riley C, et al. Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies. J Biol Chem. 1997;272:5157-66 pubmed
    ..To examine the phosphorylation of the NR1 subunit of N-methyl-D-aspartate receptors in situ, we have generated several polyclonal antibodies that recognize ..
  92. Zhou J, Liu T, Cui H, Fan R, Zhang C, Peng W, et al. Xuefu zhuyu decoction improves cognitive impairment in experimental traumatic brain injury via synaptic regulation. Oncotarget. 2017;8:72069-72081 pubmed publisher
    ..analysis revealed that the improvements of XFZYD implied the Long-term potentiation relative proteins including NMDAR1, CaMKII and GAP-43...