NPTX2

Summary

Gene Symbol: NPTX2
Description: neuronal pentraxin 2
Alias: NARP, NP-II, NP2, neuronal pentraxin-2, apexin, neuronal activity-regulated pentaxin, neuronal pentraxin II
Species: human
Products:     NPTX2

Top Publications

  1. Hsu Y, Perin M. Human neuronal pentraxin II (NPTX2): conservation, genomic structure, and chromosomal localization. Genomics. 1995;28:220-7 pubmed
    ..This pentraxin, which we propose to name neuronal pentraxin II (NPII; gene symbol NPTX2), shows 54% amino acid identity to rat neuronal pentraxin (NPI) with 69% identity ..
  2. Kirkpatrick L, Matzuk M, Dodds D, Perin M. Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2. J Biol Chem. 2000;275:17786-92 pubmed
    Neuronal pentraxin 1 (NP1), neuronal pentraxin 2 (NP2), and neuronal pentraxin receptor (NPR) are members of a new family of proteins identified through interaction with a presynaptic snake venom toxin taipoxin...
  3. Cazanave C, de Barbeyrac B. [Pelvic inflammatory diseases: Microbiologic diagnosis - CNGOF and SPILF Pelvic Inflammatory Diseases Guidelines]. Gynecol Obstet Fertil Senol. 2019;: pubmed publisher
    ..Since these sites are sterile, any bacteria present will be considered pathogenic (NP2). C...
  4. Cai M, Zhu Y, Li Z, Josephs Spaulding J, Zhou Y, Hu Y, et al. Profiling the Gene Expression and DNA Methylation in the Mouse Brain after Ischemic Preconditioning. Neuroscience. 2019;406:249-261 pubmed publisher
    ..Genes induced by IPC, including Arid5a, Nptx2 and Stc2, demonstrated a neuroprotective effect against oxygen-glucose deprivation induced neurotoxicity in vitro...
  5. Niro J, Panel P. [Interest of hysterectomy with or without bilateral oophorectomy in the surgical treatment of endometriosis: CNGOF-HAS Endometriosis Guidelines]. Gynecol Obstet Fertil Senol. 2018;46:314-318 pubmed publisher
    ..Taking into account the multiple adverse effects of early menopause on expectancy and quality of life (NP2), ovarian preservation should be discussed with the patient in case of hysterectomy for deep endometriosis (Expert ..
  6. Rocchi S, Caretti F, Gentili A, Curini R, Perret D, Perez Fernandez V. Quantitative profiling of retinyl esters in milk from different ruminant species by using high performance liquid chromatography-diode array detection-tandem mass spectrometry. Food Chem. 2016;211:455-64 pubmed publisher
    ..accomplished by fully separating the analytes on a tandem C18/C30 column system under non-aqueous reversed phase (NARP) chromatography conditions...
  7. Reddy P, Ocampo A, Suzuki K, Luo J, Bacman S, Williams S, et al. Selective elimination of mitochondrial mutations in the germline by genome editing. Cell. 2015;161:459-469 pubmed publisher
    ..for Leber's hereditary optic neuropathy (LHOND), and neurogenic muscle weakness, ataxia, and retinitis pigmentosa (NARP), in mammalian oocytes using mitochondria-targeted TALEN (mito-TALENs)...
  8. Gammage P, Gaude E, Van Haute L, Rebelo Guiomar P, Jackson C, Rorbach J, et al. Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs. Nucleic Acids Res. 2016;44:7804-16 pubmed publisher
    ..8993T>G mtDNA, associated with neuropathy, ataxia, and retinitis pigmentosa (NARP)...
  9. Attali L. [Psychological aspects of abortion]. J Gynecol Obstet Biol Reprod (Paris). 2016;45:1552-1567 pubmed publisher
    ..There is no relationship between an increase in psychiatric disorders and induced abortion (NP2). Meetings for professionals are useful and should, to the extent possible, be established (professional agreement)...

More Information

Publications122 found, 100 shown here

  1. Beccaria M, Moret E, Purcaro G, Pizzale L, Cotroneo A, Dugo P, et al. Reliability of the ΔECN42 limit and global method for extra virgin olive oil purity assessment using different analytical approaches. Food Chem. 2016;190:216-225 pubmed publisher
    ..The global method algorithm returned "correct" results for all the samples analysed (except two that gave no results) with LC-MS; on the other hand, 10 false positives were obtained elaborating data deriving from NARP-LC-RID analysis.
  2. Xu C, Tian G, Jiang C, Xue H, Kuerbanjiang M, Sun L, et al. NPTX2 promotes colorectal cancer growth and liver metastasis by the activation of the canonical Wnt/β-catenin pathway via FZD6. Cell Death Dis. 2019;10:217 pubmed publisher
    ..The expression of neuronal pentraxin 2 (NPTX2) is absent in Alzheimer's disease, anxiety, and depression...
  3. Mitra C, Gummadidala P, Merrifield R, Omebeyinje M, Jesmin R, Lead J, et al. Size and coating of engineered silver nanoparticles determine their ability to growth-independently inhibit aflatoxin biosynthesis in Aspergillus parasiticus. Appl Microbiol Biotechnol. 2019;: pubmed publisher
    ..this study, we demonstrate that three differently sized citrated-coated silver nanoparticles denoted here as NP1, NP2, and NP3 (where, sizes of NP1 < NP2 < NP3) inhibit aflatoxin biosynthesis at different effective doses in ..
  4. D Aurelio M, Vives Bauza C, Davidson M, Manfredi G. Mitochondrial DNA background modifies the bioenergetics of NARP/MILS ATP6 mutant cells. Hum Mol Genet. 2010;19:374-86 pubmed publisher
    ..associated with variable disease expression, ranging from adult onset neuropathy, ataxia and retinitis pigmentosa (NARP) to fatal childhood maternally inherited Leigh's syndrome (MILS)...
  5. Kara B, Arikan M, Maraş H, Abaci N, Cakiris A, Ustek D. Whole mitochondrial genome analysis of a family with NARP/MILS caused by m.8993T>C mutation in the MT-ATP6 gene. Mol Genet Metab. 2012;107:389-93 pubmed publisher
    Mutations in mitochondrial DNA (mtDNA) encoded nucleotide 8993 can cause NARP syndrome (neuropathy, ataxia, and retinitis pigmentosa) or MILS (maternally inherited Leigh syndrome)...
  6. Tang C, Zhang D, Yang J, Liu Q, Wang Y, Wang W. Overexpression of microRNA-301b accelerates hippocampal microglia activation and cognitive impairment in mice with depressive-like behavior through the NF-κB signaling pathway. Cell Death Dis. 2019;10:316 pubmed publisher
    ..Microarray-based prediction identified the differentially expressed gene neuronal pentraxin II (NPTX2) related to mental depression...
  7. Rocha W, Silva R, da Silva F, de Carvalho G, da Silva A, Silva J, et al. Intake, digestibility, and growth performance of Girolando bulls supplemented on pasture in Bahia, Brazil. Trop Anim Health Prod. 2019;: pubmed publisher
    ..design was repeated measurements, in a 2 × 3 factorial arrangement, with two nutritional planes (NP1 and NP2) and three seasons of the year, with 11 replicates per treatment...
  8. Beconcini D, Fabiano A, Zambito Y, Berni R, Santoni T, Piras A, et al. Chitosan-Based Nanoparticles Containing Cherry Extract from Prunus avium L. to Improve the Resistance of Endothelial Cells to Oxidative Stress. Nutrients. 2018;10: pubmed publisher
    ..CE-loaded NPs based on quaternary ammonium chitosan (NP1) and an S-protected thiolated derivative thereof (NP2) were prepared. The mean particle size (NP1 344.9 ± 17.8, NP2 339.9 ± 68...
  9. Filosto M, Cotti Piccinelli S, Lamperti C, Mongini T, Servidei S, Musumeci O, et al. Muscle pain in mitochondrial diseases: a picture from the Italian network. J Neurol. 2019;266:953-959 pubmed publisher
    ..cPEO, but also-although less frequently-in multisystem phenotypes such as MELAS, MERFF, Kearns Sayre syndrome, NARP, MNGIE and Leigh syndrome...
  10. Kucharczyk R, Dautant A, Godard F, Tribouillard Tanvier D, di Rago J. Functional investigation of an universally conserved leucine residue in subunit a of ATP synthase targeted by the pathogenic m.9176 T>G mutation. Biochim Biophys Acta Bioenerg. 2019;1860:52-59 pubmed publisher
    ..residue into arginine at amino acid position 217 of human subunit a (aL217R) has been associated to NARP (Neuropathy, Ataxia and Retinitis Pigmentosa) and MILS (Maternally Inherited Leigh's Syndrome) diseases...
  11. Pelkey K, Barksdale E, Craig M, Yuan X, Sukumaran M, Vargish G, et al. Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons. Neuron. 2015;85:1257-72 pubmed publisher
    ..upregulate GluA4 during the second postnatal week coincident with increases in the AMPAR clustering proteins NPTX2 and NPTXR...
  12. Gentili A, Dal Bosco C, Fanali S, Fanali C. Large-scale profiling of carotenoids by using non aqueous reversed phase liquid chromatography - photodiode array detection - triple quadrupole linear ion trap mass spectrometry: Application to some varieties of sweet pepper (Capsicum annuum L.). J Pharm Biomed Anal. 2019;164:759-767 pubmed publisher
    ..Separation was realized by means of Non-Aqueous Reversed Phase (NARP) chromatography on a triacontyl stationary phase kept at subambient temperature, using a mobile phase compatible ..
  13. Delorme P, Garabedian C. [Modalities of birth in case of uncomplicated preterm premature rupture of membranes: CNGOF Preterm Premature Rupture of Membranes Guidelines]. Gynecol Obstet Fertil Senol. 2018;46:1068-1075 pubmed publisher
    ..management for pPROM is not associated with neonatal sepsis (NP1) but is associated to intra-uterine infection (NP2)...
  14. Pienkowski C, Cartault A. [Contraception for adolescent : CNGOF Contraception guidelines]. Gynecol Obstet Fertil Senol. 2018;46:858-864 pubmed publisher
    ..them the choice of contraceptive method and provide objective information on the different contraceptive methods (NP2)...
  15. Mori M, Mytinger J, Martin L, Bartholomew D, Hickey S. m.8993T>G-Associated Leigh Syndrome with Hypocitrullinemia on Newborn Screening. JIMD Rep. 2014;17:47-51 pubmed publisher
    ..been diagnosed with cerebral palsy, was concurrently diagnosed with neuropathy, ataxia, and retinitis pigmentosa (NARP) due to heteroplasmy of the same mutation. She had progressive muscle weakness, ataxia, and speech dyspraxia. The m...
  16. Tiwari V, Patel M, Chaturvedi A, Mishra A, Jha B. Cloning and functional characterization of the Na+/H+ antiporter (NHX1) gene promoter from an extreme halophyte Salicornia brachiata. Gene. 2018;683:233-242 pubmed publisher
    ..with a transcriptional fusion of GUS with the full SbNHX1 promoter (NP1) or any of its five deletion fragments (NP2 to NP6), showed that the deletion of two enhancer motifs resulted in the sudden decrease in GUS expression in ..
  17. Thatipamula S, Hossain M. Critical role of extracellularly secreted neuronal pentraxin 1 in ischemic neuronal death. BMC Neurosci. 2014;15:133 pubmed publisher
    ..Most strikingly, in contrast to NP1-KO CM, incubation of normal cortical cultures with CM from OGD exposed NP2-KO cultures showed neurotoxicity similar to that observed with CM from OGD exposed WT neuronal cultures...
  18. Picone O. [Genital herpes and pregnancy: Epidemiology, clinical manifestations, prevention and screening. Guidelines for clinical practice from the French College of Gynecologists and Obstetrician (CNGOF)]. Gynecol Obstet Fertil Senol. 2017;45:642-654 pubmed publisher
    ..The symptomatology of herpes genital rash is often atypical (NP2) and not different during pregnancy (Professional consensus). It is most often due to HSV2 (NP2)...
  19. Cui K, Tai W, Shan X, Hao J, Li G, Yu G. Structural characterization and anti-thrombotic properties of fucoidan from Nemacystus decipiens. Int J Biol Macromol. 2018;120:1817-1822 pubmed publisher
    The sulfated polysaccharide NP2 was isolated and purified from Nemacystus decipiens, the structure and antithrombotic activity of NP2 was further studied...
  20. Pariona N, Martínez A, Hernandez Flores H, Clark Tapia R. Effect of magnetite nanoparticles on the germination and early growth of Quercus macdougallii. Sci Total Environ. 2017;575:869-875 pubmed publisher
    ..Two types of Fe3O4-NPs were synthetized and characterized, being denominated NP1 and NP2. The synthesis was performed by the co-precipitation method and partial reduction of iron(II), respectively...
  21. Wojewoda M, Walczak J, Duszyński J, Szczepanowska J. Selenite activates the ATM kinase-dependent DNA repair pathway in human osteosarcoma cells with mitochondrial dysfunction. Biochem Pharmacol. 2015;95:170-6 pubmed publisher
    ..findings that ROS level was higher in human osteosarcoma cybrids--Neuropathy, Ataxia and Retinitis Pigmentosa (NARP) and was reduced by selenite treatment, this study was designed to elucidate the effects of selenite administration ..
  22. Liu H, Luo K, Luo D. Guanosine monophosphate reductase 1 is a potential therapeutic target for Alzheimer's disease. Sci Rep. 2018;8:2759 pubmed publisher
    ..Here, we conducted analysis to identify age-independent, AD-specific genes. We found that the MET, WIF1, and NPTX2 genes are downregulated in AD...
  23. Elbaz I, Lerer Goldshtein T, Okamoto H, Appelbaum L. Reduced synaptic density and deficient locomotor response in neuronal activity-regulated pentraxin 2a mutant zebrafish. FASEB J. 2015;29:1220-34 pubmed publisher
    Neuronal-activity-regulated pentraxin (NARP/NPTX2/NP2) is a secreted synaptic protein that regulates the trafficking of glutamate receptors and mediates learning, memory, and drug addiction...
  24. Botlagunta M. Neuronal pentraxin 1 expression is regulated by hypoxia inducible factor-1α. Biochem Biophys Res Commun. 2015;456:662-5 pubmed publisher
    ..pentraxins (NPs) are belong to sub family of long pentraxin proteins consist of neuronal pentraxin 1 (NP1), neuronal pentraxin 2 (NP2), and neuronal pentraxin receptor (NPR)...
  25. Chang M, Park J, Pelkey K, Grabenstatter H, Xu D, Linden D, et al. Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons. Nat Neurosci. 2010;13:1090-7 pubmed publisher
    ..The immediate-early gene Narp (neuronal activity-regulated pentraxin) encodes a secreted synaptic protein that can bind to and induce clustering ..
  26. Aretini P, Mazzanti C, La Ferla M, Franceschi S, Lessi F, De Gregorio V, et al. Next generation sequencing technologies for a successful diagnosis in a cold case of Leigh syndrome. BMC Neurol. 2018;18:99 pubmed publisher
    ..Genetic analyses of the whole mtDNA for maternally inherited LS (MILS) and neuropathy ataxia retinitis pigmentosa (NARP) syndrome failed to reveal any pathogenic mutations...
  27. Rezanka T, Kolouchová I, Nedbalová L, Sigler K. Enantiomeric separation of triacylglycerols containing very long chain fatty acids. J Chromatogr A. 2018;1557:9-19 pubmed publisher
    ..liquid chromatography/high resolution atmospheric pressure chemical ionization-tandem mass spectrometry (NARP-HPLC/HRMS2-APCI) and chiral liquid chromatography were used for the separation and identification of ..
  28. Hao Y, Updegrove T, Livingston N, Storz G. Protection against deleterious nitrogen compounds: role of ?S-dependent small RNAs encoded adjacent to sdiA. Nucleic Acids Res. 2016;44:6935-48 pubmed publisher
    ..Low temperature, rich nitrogen sources and the Crl and NarP transcription factors differentially affect the levels of the SdsN transcripts...
  29. Chang S, Bok P, Tsai C, Sun C, Liu H, Deussing J, et al. NPTX2 is a key component in the regulation of anxiety. Neuropsychopharmacology. 2018;43:1943-1953 pubmed publisher
    ..Previous studies have suggested that the expression of the Nptx2 gene is associated with anxiety, but the neurobiological processes underlying this association remain unclear...
  30. Clark I, Melnyk R, Youngblut M, Carlson H, Iavarone A, Coates J. Synthetic and Evolutionary Construction of a Chlorate-Reducing Shewanella oneidensis MR-1. MBio. 2015;6:e00282-15 pubmed publisher
    ..polymorphism (SNP) upstream of cld enabled growth on chlorate and was epistatic to a second base pair change in the NarP binding sequence between narQP and nrfA that enhanced growth...
  31. Gelfand J, Duncan J, Racine C, Gillum L, Chin C, Zhang Y, et al. Heterogeneous patterns of tissue injury in NARP syndrome. J Neurol. 2011;258:440-8 pubmed publisher
    ..8993T>G of the mtDNA ATPase 6 gene cause the neurogenic weakness, ataxia and retinitis pigmentosa (NARP) syndrome, a mitochondrial disorder characterized by retinal, central and peripheral neurodegeneration...
  32. Kuttappan V, Bielke L, Wolfenden A, Berghman L, Tellez G, Hargis B, et al. Comparison of different ELISA protocols for the detection of IgA against influenza nucleoproteins in trachea of vaccinated chickens. Poult Sci. 2015;94:181-4 pubmed publisher
    ..Positive control tracheas were obtained through hyperimmunization of birds with adjuvated NP1 and NP2 peptide conjugated with keyhole limpet hemocyanin administered both orally and parenterally; negative birds ..
  33. Maisonneuve E. [Lifestyle recommendations for prevention of spontaneous preterm birth in asymptomatic pregnant women]. J Gynecol Obstet Biol Reprod (Paris). 2016;45:1231-1246 pubmed publisher
    ..Smoking is associated with spontaneous preterm birth (NP2)...
  34. Huynh T, Chen L, Stewart V. Sensor-response regulator interactions in a cross-regulated signal transduction network. Microbiology. 2015;161:1504-15 pubmed publisher
    ..for a cross-regulation network, in which the paralogous sensor-response regulator pairs, NarX-NarL and NarQ-NarP, exhibit both cognate (e.g. NarX-NarL) and non-cognate (e.g. NarQ-NarL) interactions to control output...
  35. Valero T. Mitochondrial biogenesis: pharmacological approaches. Curr Pharm Des. 2014;20:5507-9 pubmed
    ..hereditary optic neuropathy (LHON), the syndrome of neurogenic muscle weakness, ataxia and retinitis pigmentosa (NARP), and Leigh's syndrome...
  36. Dumitrescu R. Early Epigenetic Markers for Precision Medicine. Methods Mol Biol. 2018;1856:3-17 pubmed publisher
    ..Similarly, in pancreatic cancers, abnormal DNA methylation of several genes including NPTX2, have been suggested as a diagnostic biomarker...
  37. Lu Y, Zhao H, Zhang C, Xing X. Insights into the global regulation of anaerobic metabolism for improved biohydrogen production. Bioresour Technol. 2016;200:35-41 pubmed publisher
    ..Two cellular global regulators FNR and NarP were overexpressed in two model organisms: facultatively anaerobic Enterobacter aerogenes (Ea) and strictly ..
  38. Kowalski A, Huang Y. Predicting and priming thematic roles: Flexible use of verbal and nonverbal cues during relative clause comprehension. J Exp Psychol Learn Mem Cogn. 2017;43:1341-1351 pubmed publisher
    ..are distinguished from subject-relative clauses (SRCs) after the second noun phrase (NP2; e.g., SRCs: "The bear that pushed . . ."), role assignments are often delayed until the embedded verb (e.g., ". . ...
  39. Charbonnier Beaupel F, Malerbi M, Alcacer C, Tahiri K, Carpentier W, Wang C, et al. Gene expression analyses identify Narp contribution in the development of L-DOPA-induced dyskinesia. J Neurosci. 2015;35:96-111 pubmed publisher
    ..The intersection list identified five genes: FosB, Th, Nptx2, Nedd4l, and Ccrn4l. Nptx2 encodes neuronal pentraxin II (or neuronal activity-regulated pentraxin, Narp), which is involved in the clustering of glutamate ..
  40. Berti V, Murray J, Davies M, Spector N, Tsui W, Li Y, et al. Nutrient patterns and brain biomarkers of Alzheimer's disease in cognitively normal individuals. J Nutr Health Aging. 2015;19:413-23 pubmed publisher
    ..Five NPs were identified: NP1 was characterized by most B-vitamins and several minerals [VitB and Minerals]; NP2 by monounsaturated and polyunsaturated fats, including ω-3 and ω-6 PUFA, and vitamin E [VitE and PUFA]; NP3 ..
  41. Jebali A, Anvari Tafti M. Hybridization of different antisense oligonucleotides on the surface of gold nanoparticles to silence zinc metalloproteinase gene after uptake by Leishmania major. Colloids Surf B Biointerfaces. 2015;129:107-13 pubmed publisher
    ..NP1) were separately hybridized with three types of antisense oligonucleotide from coding reign of GP63 gene (NP2), non-coding reign of GP63 gene (NP3), and both coding and non-coding reigns of GP63 (NP4). Then, 1mL of L...
  42. García Orza J, Gavilán J, Fraga I, Ferré P. Testing the online reading effects of emotionality on relative clause attachment. Cogn Process. 2017;18:543-553 pubmed publisher
    ..g.,: Someone shot the servant (the first noun phrase, NP1) of the actress (the second noun phrase, NP2) who was on the balcony] (Fraga et al. in Q J Exp Psychol 65:1740-1759, 2012)...
  43. Mizurini D, Francischetti I, Andersen J, Monteiro R. Nitrophorin 2, a factor IX(a)-directed anticoagulant, inhibits arterial thrombosis without impairing haemostasis. Thromb Haemost. 2010;104:1116-23 pubmed publisher
    Nitrophorin 2 (NP2) is a 20 kDa lipocalin identified in the salivary gland of the blood sucking insect, Rhodnius prolixus. It functions as a potent inhibitor of the intrinsic pathway of coagulation upon binding to factor IX (FIX) or FIXa...
  44. Thatipamula S, Al Rahim M, Zhang J, Hossain M. Genetic deletion of neuronal pentraxin 1 expression prevents brain injury in a neonatal mouse model of cerebral hypoxia-ischemia. Neurobiol Dis. 2015;75:15-30 pubmed publisher
    ..To further delineate the specificity of NPs, we found that NP1 but not the NP2 induction is specifically involved in brain injury mechanisms and that knockdown of NP1 only results in ..
  45. Schrödter S, Braun M, Syring I, Klümper N, Deng M, Schmidt D, et al. Identification of the dopamine transporter SLC6A3 as a biomarker for patients with renal cell carcinoma. Mol Cancer. 2016;15:10 pubmed publisher
    ..expression of fourteen mRNAs, yet not studied in ccRCC in depth, was confirmed using qPCR (upregulation: SLC6A3, NPTX2, TNFAIP6, NDUFA4L2, ENPP3, FABP6, SPINK13; downregulation: FXYD4, SLC12A1, KNG1, NPHS2, SLC13A3, GCGR, PLG)...
  46. Thomassin Naggara I, Bendifallah S, Rousset P, Bazot M, Ballester M, Darai E. [Diagnostic performance of MR imaging, coloscan and MRI/CT enterography for the diagnosis of pelvic endometriosis: CNGOF-HAS Endometriosis Guidelines]. Gynecol Obstet Fertil Senol. 2018;46:177-184 pubmed publisher
    ..exists according the location considered, the risk of misdiagnosis is lower than 10% for trained teams (NP2)...
  47. Hmida D, Abderrabba M, Tchapla A, Héron S, Moussa F. Comparison of iso-eluotropic mobile phases at different temperatures for the separation of triacylglycerols in Non-Aqueous Reversed Phase Liquid Chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;990:45-51 pubmed publisher
    ..Their analyses in Non-Aqueous Reversed Phase Liquid Chromatography (NARP) require a mixture of weak solvent (mostly acetonitrile) and strong solvent...
  48. Barr M, Gray S, Gately K, Hams E, Fallon P, Davies A, et al. Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer. Mol Cancer. 2015;14:45 pubmed publisher
    ..Inhibition of the VEGF pathway with anti-VEGF and anti-VEGFR-2 antibodies or siRNA to VEGF, NP1 and NP2 resulted in growth inhibition of NP1 positive tumor cell lines associated with down-regulation of PI3K and MAPK ..
  49. Huang Y, Yan J, Hou J, Fu X, Li L, Hou Y. Developing a DNA methylation assay for human age prediction in blood and bloodstain. Forensic Sci Int Genet. 2015;17:129-136 pubmed publisher
    ..The model included four AR-CpG markers in three gene fragments ASPA, ITGA2B and NPTX2 and enabled the age prediction with R(2)=0.819...
  50. Tang X, Sun J, Du L, Du H, Wang L, Mai J, et al. Neuropilin-2 contributes to LPS-induced corneal inflammatory lymphangiogenesis. Exp Eye Res. 2016;143:110-9 pubmed publisher
    Neuropilin-2 (NP2), a high-affinity kinase-deficient co-receptor for vascular endothelial growth factor (VEGF)-C, is involved in embryonic vessel development, tumor growth, tumor lymphangiogenesis and metastasis...
  51. Tamba Sompila A, Heron S, Hmida D, Tchapla A. Fast non-aqueous reversed-phase liquid chromatography separation of triacylglycerol regioisomers with isocratic mobile phase. Application to different oils and fats. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1041-1042:151-157 pubmed publisher
    ..mobile phase composition and analysis temperature) using Non-Aqueous Reversed Phase Liquid Chromatography (NARP-LC)...
  52. Mawlood S, Dennany L, Watson N, Pickard B. The EpiTect Methyl qPCR Assay as novel age estimation method in forensic biology. Forensic Sci Int. 2016;264:132-8 pubmed publisher
    ..promoter regions of a number of age related genes, of which four successfully showed changes across the lifespan (NPTX2, KCNQ1DN, GRIA2 and TRIM58)...
  53. Rasmussen S, Krarup H, Sunesen K, Johansen M, Stender M, Pedersen I, et al. Hypermethylated DNA, a circulating biomarker for colorectal cancer detection. PLoS ONE. 2017;12:e0180809 pubmed publisher
    ..However, seven hypermethylated promoter regions (ALX4, BMP3, NPTX2, RARB, SDC2, SEPT9, and VIM) along with the covariates sex and age yielded an optimism corrected AUC of 0...
  54. Sakry D, Yigit H, Dimou L, Trotter J. Oligodendrocyte precursor cells synthesize neuromodulatory factors. PLoS ONE. 2015;10:e0127222 pubmed publisher
    ..that OPC express two well-characterized neuromodulatory proteins: Prostaglandin D2 synthase (PTGDS) and neuronal Pentraxin 2 (Nptx2/Narp)...
  55. Lee S, Wei M, Zhang C, Maxeiner S, Pak C, Calado Botelho S, et al. Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and Inhibitory Synapses. J Neurosci. 2017;37:1062-1080 pubmed publisher
    ..are expressed in brain, the membrane-bound "neuronal pentraxin receptor" (NPR) and the secreted proteins NP1 and NARP (i.e., NP2)...
  56. Gómez Chacón B, Gámiz F, Foster T, Gallo M. Increased N-Ethylmaleimide-Sensitive Factor Expression in Amygdala and Perirhinal Cortex during Habituation of Taste Neophobia. Neural Plast. 2016;2016:2726745 pubmed publisher
    ..In addition the expression of the synaptic plasticity related immediate early genes, Homer 1 and Narp, was also assessed...
  57. Isohanni P, Carroll C, Jackson C, Pohjanpelto M, Lonnqvist T, Suomalainen A. Defective mitochondrial ATPase due to rare mtDNA m.8969G>A mutation-causing lactic acidosis, intellectual disability, and poor growth. Neurogenetics. 2018;19:49-53 pubmed publisher
    Mutations in mitochondrial ATP synthase 6 (MT-ATP6) are a frequent cause of NARP (neurogenic muscle weakness, ataxia, and retinitis pigmentosa) or Leigh syndromes, especially a point mutation at nucleotide position 8993. M...
  58. Huchon C, Aubry G, Ploteau S, Fauconnier A. [Specific clinical signs suggestive of endometriosis (excluding adenomyosis) and questionnaires of symptoms, pain and quality of life: CNGOF-HAS Endometriosis Guidelines]. Gynecol Obstet Fertil Senol. 2018;46:168-176 pubmed publisher
    ..The main symptoms suggestive of endometriosis are: severe dysmenorrhea (NP2), deep dyspareunia (NP2), painful defecation during menstruation (NP2), urinary tract symptoms during menstruation (..
  59. Řezanka T, Lukavský J, Vítová M, Nedbalová L, Sigler K. Lipidomic analysis of Botryococcus (Trebouxiophyceae, Chlorophyta) - Identification of lipid classes containing very long chain fatty acids by offline two-dimensional LC-tandem MS. Phytochemistry. 2018;148:29-38 pubmed publisher
    ..Using non-aqueous reversed-phase liquid chromatography tandem mass spectrometry (NARP-LC/MS2) of the appropriate collected fractions, molecular species of triacylglycerols containing one or ..
  60. Rezanka T, Nedbalová L, Sigler K. Enantiomeric separation of triacylglycerols containing polyunsaturated fatty acids with 18 carbon atoms. J Chromatogr A. 2016;1467:261-269 pubmed publisher
    ..organic liquid chromatography/high resolution atmospheric pressure chemical ionization-tandem mass spectrometry (NARP-LC/HRMS2-APCI) and chiral liquid chromatography were used for the separation and identification of ..
  61. Marret S, Ancel P. [Neuroprotection for preterm infants with antenatal magnesium sulphate]. J Gynecol Obstet Biol Reprod (Paris). 2016;45:1418-1433 pubmed publisher
    ..age, or depending on the type of pregnancy (single or multiple pregnancy) or with the cause of preterm birth (NP2)...
  62. Cayrac M, Warembourg S, Le Normand L, Fatton B. [Does hysterectomy modifies the anatomical and functional outcomes of prolapse surgery?: Clinical Practice Guidelines]. Prog Urol. 2016;26 Suppl 1:S73-88 pubmed publisher
    ..retrospective comparative studies and in a meta-analysis with reduced operating time, blood loss and recovery time (NP2)...
  63. Kimoto S, Zaki M, Bazmi H, Lewis D. Altered Markers of Cortical γ-Aminobutyric Acid Neuronal Activity in Schizophrenia: Role of the NARP Gene. JAMA Psychiatry. 2015;72:747-56 pubmed publisher
    ..To quantify in individuals with schizophrenia the expression of immediate early genes (NARP, ARC, and SGK1) regulating glutamate synaptic neurotransmission...
  64. Borghese B, Santulli P, Marcellin L, Chapron C. [Definition, description, clinicopathological features, pathogenesis and natural history of endometriosis: CNGOF-HAS Endometriosis Guidelines]. Gynecol Obstet Fertil Senol. 2018;46:156-167 pubmed publisher
    ..The pelvic factor can be fixed by surgical excision of the lesions that improves the chance of natural conception (NP2)...
  65. Song Y, Wang J, Gao Y. Effects of epiphytic algae on biomass and physiology of Myriophyllum spicatum L. with the increase of nitrogen and phosphorus availability in the water body. Environ Sci Pollut Res Int. 2017;24:9548-9555 pubmed publisher
    ..5-0.05, NP2 2.5-0.25, NP3 4.5-0.45) and two levels of epiphytic algae (the epiphytic algae group and the control group)...
  66. Peng Y, Tso C, Tsai Y, Zhuang C, Shih Y. The effect of electrolytes on the aggregation kinetics of three different ZnO nanoparticles in water. Sci Total Environ. 2015;530-531:183-190 pubmed publisher
    ..on the stabilities of three ZnO NPs were compared: the commercial powder (NP1), the lab synthesized suspension (NP2) and the commercial suspension (NP3)...
  67. Eikrem O, Beisland C, Hjelle K, Flatberg A, Scherer A, Landolt L, et al. Transcriptome Sequencing (RNAseq) Enables Utilization of Formalin-Fixed, Paraffin-Embedded Biopsies with Clear Cell Renal Cell Carcinoma for Exploration of Disease Biology and Biomarker Development. PLoS ONE. 2016;11:e0149743 pubmed publisher
    ..transcripts with the highest fold changes in both datasets were carbonic anhydrase 9 (CA9), neuronal pentraxin-2 (NPTX2) and uromodulin (UMOD) that were confirmed by immunohistochemistry...
  68. Nedbalová L, Střížek A, Sigler K, Rezanka T. Effect of salinity on the fatty acid and triacylglycerol composition of five haptophyte algae from the genera Coccolithophora, Isochrysis and Prymnesium determined by LC-MS/APCI. Phytochemistry. 2016;130:64-76 pubmed publisher
    Non-aqueous reversed-phase high-performance liquid chromatography (NARP-HPLC) with atmospheric pressure chemical ionization (APCI) was used for separation of triacylglycerols from five strains of haptophyte algae (genera Coccolithophora, ..
  69. Dingle G, Williams E, Jetten J, Welch J. Choir singing and creative writing enhance emotion regulation in adults with chronic mental health conditions. Br J Clin Psychol. 2017;56:443-457 pubmed publisher
    ..044, p < .001, np2 = .319; and a decrease in negative emotions during the arts-based activity: F (2.637, 155.597) = 21...
  70. Mariga A, Glaser J, Mathias L, Xu D, Xiao M, Worley P, et al. Definition of a Bidirectional Activity-Dependent Pathway Involving BDNF and Narp. Cell Rep. 2015;13:1747-56 pubmed publisher
    ..The immediate early gene neuronal-activity-regulated pentraxin (NPTX2 or Narp) encodes a protein that has been associated with excitatory synaptogenesis, AMPA receptor aggregation, and ..
  71. Southern T, Racsa L, Albariño C, Fey P, Hinrichs S, Murphy C, et al. Comparison of FilmArray and Quantitative Real-Time Reverse Transcriptase PCR for Detection of Zaire Ebolavirus from Contrived and Clinical Specimens. J Clin Microbiol. 2015;53:2956-60 pubmed publisher
    ..of ZEBOV nucleic acids, including the BioFire FilmArray BioThreat (BT) panel, the FilmArray BT-E panel, and the NP2 and VP40 quantitative real-time reverse transcriptase (qRT) PCR assays from the Centers for Disease Control and ..
  72. Maradonna F, Nozzi V, Santangeli S, Traversi I, Gallo P, Fattore E, et al. Xenobiotic-contaminated diets affect hepatic lipid metabolism: Implications for liver steatosis in Sparus aurata juveniles. Aquat Toxicol. 2015;167:257-64 pubmed publisher
    ..Pepck mRNA was significantly overexpressed in fish exposed to NP2 and both t-OP doses...
  73. Legendre G, Delbos L, Hudon E, Chabbert Buffet N, Geoffron S, Sauvan M, et al. [New medical treatments for painful endometriosis: CNGOF-HAS Endometriosis Guidelines]. Gynecol Obstet Fertil Senol. 2018;46:256-263 pubmed publisher
    ..Dienogest is effective compared to placebo in short term (NP2) and long term (NP4) for the treatment of painful endometriosis...
  74. Borm K, Jakobsen M, Cashin K, Flynn J, Ellenberg P, Ostergaard L, et al. Frequency and Env determinants of HIV-1 subtype C strains from antiretroviral therapy-naive subjects that display incomplete inhibition by maraviroc. Retrovirology. 2016;13:74 pubmed
    ..Specifically, when pseudotyped onto luciferase reporter viruses, 16 Envs exhibited MPIs below 98% in NP2-CCR5 cells (range 79.7-97...
  75. Ji P, Schachtschneider K, Schook L, Walker F, Johnson R. Peripheral viral infection induced microglial sensome genes and enhanced microglial cell activity in the hippocampus of neonatal piglets. Brain Behav Immun. 2016;54:243-251 pubmed publisher
    ..g., IL1R1, TLR2, and TLR4), whereas 15 genes associated with the synaptosome and synaptic receptors (e.g., NPTX2, GABRA2, and SLC5A7) were down-regulated...
  76. Kone M, Pullen T, Sun G, Ibberson M, Martinez Sanchez A, Sayers S, et al. LKB1 and AMPK differentially regulate pancreatic β-cell identity. FASEB J. 2014;28:4972-85 pubmed publisher
    ..0-12-fold, E<0.01) increased the expression of subsets of hepatic (Alb, Iyd, Elovl2) and neuronal (Nptx2, Dlgap2, Cartpt, Pdyn) genes, enhancing glutamate signaling...
  77. Lee Y, Lewis J, Ippolito D, Hussainzada N, Lein P, Jackson D, et al. Repeated exposure to neurotoxic levels of chlorpyrifos alters hippocampal expression of neurotrophins and neuropeptides. Toxicology. 2016;340:53-62 pubmed publisher
    ..Differential expression of six of these genes (Bdnf, Cort, Crhbp, Nptx2, Npy and Pnoc) was verified in an independent CPF exposure study; immunohistochemistry demonstrated that CRHBP and ..
  78. Lopez C, Rivera Chávez F, Byndloss M, Bäumler A. The Periplasmic Nitrate Reductase NapABC Supports Luminal Growth of Salmonella enterica Serovar Typhimurium during Colitis. Infect Immun. 2015;83:3470-8 pubmed publisher
    ..Inactivation of narP, encoding a response regulator that activates napABC transcription in response to low nitrate concentrations, ..
  79. Kytövuori L, Lipponen J, Rusanen H, Komulainen T, Martikainen M, Majamaa K. A novel mutation m.8561C>G in MT-ATP6/8 causing a mitochondrial syndrome with ataxia, peripheral neuropathy, diabetes mellitus, and hypergonadotropic hypogonadism. J Neurol. 2016;263:2188-2195 pubmed
    ..in MT-ATP6 are associated with the Leigh syndrome, the syndrome of neuropathy, ataxia, and retinitis pigmentosa (NARP), as well as with non-classical phenotypes, while MT-ATP8 is less frequently mutated in patients with mitochondrial ..
  80. Benoist G. [Prediction of preterm delivery in symptomatic women (preterm labor)]. J Gynecol Obstet Biol Reprod (Paris). 2016;45:1346-1363 pubmed publisher
    ..of the cervix (Bishop score) by vaginal examination is an effective parameter for the prediction of preterm birth (NP2). The higher the Bishop score, the higher the risk of preterm birth (NP3)...
  81. Park J, Ryu J, Lee K, Lee J, Yoon W, Lee S, et al. Quantitative analysis of NPTX2 hypermethylation is a promising molecular diagnostic marker for pancreatic cancer. Pancreas. 2007;35:e9-15 pubmed
    ..The ERCP-guided pancreatic duct brush cytology samples were obtained. Genomic DNA was extracted, and NPTX2 CpG island hypermethylation was examined quantitatively by real-time polymerase chain reaction amplification after ..
  82. Zhang L, Gao J, Li Z, Gong Y. Neuronal pentraxin II (NPTX2) is frequently down-regulated by promoter hypermethylation in pancreatic cancers. Dig Dis Sci. 2012;57:2608-14 pubmed
    Gene silencing via promoter hypermethylation plays a crucial role in the pathogenesis of cancers. Neuronal pentraxin II (NPTX2) has been observed to be hypermethylated in pancreatic cancers...
  83. Gu Y, Huang S, Chang M, Worley P, Kirkwood A, Quinlan E. Obligatory role for the immediate early gene NARP in critical period plasticity. Neuron. 2013;79:335-46 pubmed publisher
    The immediate early gene neuronal activity-regulated pentraxin (NARP) is an ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) binding protein that is specifically enriched at excitatory synapses onto fast-spiking ..
  84. Lemoine S, Panaye M, Rabeyrin M, Errazuriz Cerda E, Mousson de Camaret B, Petiot P, et al. Renal Involvement in Neuropathy, Ataxia, Retinitis Pigmentosa (NARP) Syndrome: A Case Report. Am J Kidney Dis. 2018;71:754-757 pubmed publisher
    ..a case of a patient who had the mitochondrial cytopathy complex of neuropathy, ataxia, and retinitis pigmentosa (NARP) syndrome diagnosed at age 11 years with a biopsy-proven kidney involvement that progressed to end-stage renal ..
  85. Skiriute D, Vaitkiene P, Asmoniene V, Steponaitis G, Deltuva V, Tamasauskas A. Promoter methylation of AREG, HOXA11, hMLH1, NDRG2, NPTX2 and Tes genes in glioblastoma. J Neurooncol. 2013;113:441-9 pubmed publisher
    ..AREG gene might be valuable marker for glioblastoma patient survival prognosis, however further analysis is needed to clarify the independence and appropriateness of the marker. ..
  86. Shukla S, Pia Patric I, Thinagararjan S, Srinivasan S, Mondal B, Hegde A, et al. A DNA methylation prognostic signature of glioblastoma: identification of NPTX2-PTEN-NF-?B nexus. Cancer Res. 2013;73:6563-73 pubmed publisher
    ..Promoter hypermethylation of neuronal pentraxin II (NPTX2), a risky methylated gene, was confirmed by bisulfite sequencing in GBMs...
  87. Walczak J, Partyka M, Duszynski J, Szczepanowska J. Implications of mitochondrial network organization in mitochondrial stress signalling in NARP cybrid and Rho0 cells. Sci Rep. 2017;7:14864 pubmed publisher
    ..model subjected to specifically designed chronic mitochondrial stress: WT human osteosarcoma cells as controls, NARP cybrid cells as mild chronic stress and Rho0 as severe chronic stress...
  88. Poulsen T, Pedersen N, Perin M, Hansen C, Poulsen H. Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin. Lung Cancer. 2005;50:329-37 pubmed
    ..expressed in neurons, where it associates with the homologous proteins neuronal pentraxins 1 and 2 (NP1 and NP2) in complexes capable of binding the snake venom neurotoxin taipoxin...
  89. Zhang L, Gao J, Li L, Li Z, Du Y, Gong Y. The neuronal pentraxin II gene (NPTX2) inhibit proliferation and invasion of pancreatic cancer cells in vitro. Mol Biol Rep. 2011;38:4903-11 pubmed publisher
    The neuronal pentraxin II gene (NPTX2) is expressed in numerous tissues, such as the pancreas and the liver. While its activity in the brain is known to be regulated by neuronal activity, its function in the pancreas is unclear...
  90. Yao F, Sun M, Dong M, Jing F, Chen B, Xu H, et al. NPTX2 hypermethylation in pure pancreatic juice predicts pancreatic neoplasms. Am J Med Sci. 2013;346:175-80 pubmed publisher
    The neuronal pentraxin II (NPTX2) gene is methylated in over 90% primary pancreatic cancer tissues but rarely in normal pancreatic ductal epithelia...
  91. Manchia M, Piras I, Huentelman M, Pinna F, Zai C, Kennedy J, et al. Pattern of gene expression in different stages of schizophrenia: Down-regulation of NPTX2 gene revealed by a meta-analysis of microarray datasets. Eur Neuropsychopharmacol. 2017;27:1054-1063 pubmed publisher
    ..b>Neuronal pentraxin 2 (NPTX2) gene was consistently down-regulated across all datasets, with highly significant association in ..