NPEPPS

Summary

Gene Symbol: NPEPPS
Description: aminopeptidase puromycin sensitive
Alias: AAP-S, MP100, PSA, puromycin-sensitive aminopeptidase, cytosol alanyl aminopeptidase, metalloproteinase MP100
Species: human
Products:     NPEPPS

Top Publications

  1. Constam D, Tobler A, Rensing Ehl A, Kemler I, Hersh L, Fontana A. Puromycin-sensitive aminopeptidase. Sequence analysis, expression, and functional characterization. J Biol Chem. 1995;270:26931-9 pubmed
    ..Here we report on the analysis of a novel mouse cDNA encoding the puromycin-sensitive aminopeptidase (PSA) and on its expression in COS cells and 3T3 fibroblasts...
  2. Stoltze L, Schirle M, Schwarz G, Schroter C, Thompson M, Hersh L, et al. Two new proteases in the MHC class I processing pathway. Nat Immunol. 2000;1:413-8 pubmed
    ..Our data provide evidence for the existence of redundant systems acting downstream of the proteasome in the antigen-processing pathway for MHC class I molecules. ..
  3. Beninga J, Rock K, Goldberg A. Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase. J Biol Chem. 1998;273:18734-42 pubmed
    ..This enzyme appears to catalyze the trimming of the N terminus of this and presumably other proteasome-derived precursors. Thus, susceptibility to LAP may be an important influence on the generation on immunodominant epitopes. ..
  4. Michaelsen F, Saeed M, Schwarzkopf J, Efferth T. Activity of Artemisia annua and artemisinin derivatives, in prostate carcinoma. Phytomedicine. 2015;22:1223-31 pubmed publisher
    ..A patient with prostate carcinoma (pT3bN1M1, Gleason score 8 (4+4)) presented with a prostate specific antigen (PSA) level >800 µg/l...
  5. Chang W, Tsai Y, Wang J, Chen H, Yang W, Lee C. Sex hormones and oxidative stress mediated phthalate-induced effects in prostatic enlargement. Environ Int. 2019;126:184-192 pubmed publisher
    ..ratios, inducible nitric oxide synthetase (iNOS), 8-hydroxy-2'-deoxyguanosine (8-OHdG), prostate specific antigen (PSA), and prostate volume (PV) (p < 0.05)...
  6. Nickerson M, Das S, Im K, Turan S, Berndt S, Li H, et al. TET2 binds the androgen receptor and loss is associated with prostate cancer. Oncogene. 2017;36:2172-2183 pubmed publisher
    ..AR) and AR-coactivator proteins in LNCaP cell extracts, and TET2 KD increases prostate-specific antigen (KLK3/PSA) expression. Published data reveal TET2 binding sites and hydroxymethylcytosine proximal to KLK3...
  7. Traish A, Haider K, Doros G, Haider A. Long-term dutasteride therapy in men with benign prostatic hyperplasia alters glucose and lipid profiles and increases severity of erectile dysfunction. Horm Mol Biol Clin Investig. 2017;30: pubmed publisher
    ..significant improvements in LUTS, as assessed by reduction in prostate volume, IPSS and prostate specific antigen (PSA)...
  8. Kawamoto Y, Kondo H, Hasegawa M, Kurimoto C, Ishii Y, Kato C, et al. Inhibition of mast cell degranulation by melanin. Biochem Pharmacol. 2019;163:178-193 pubmed publisher
    ..In vivo experiments using passive systemic anaphylaxis (PSA) and passive cutaneous anaphylaxis (PCA) mouse models demonstrated that oral administration of melanin accelerated ..
  9. Du F, Fan J, Wang T, Wu Y, Grierson D, Gao Z, et al. Identification of differentially expressed genes in flower, leaf and bulb scale of Lilium oriental hybrid 'Sorbonne' and putative control network for scent genes. BMC Genomics. 2017;18:899 pubmed publisher
    ..starch branching enzyme (SBE), ADP-glucose pyrophosphorylase (AGP) and?-amylase (BAM) and photosynthesis genes (Psa, Psb, Pet and ATP) were also identified...

More Information

Publications155 found, 100 shown here

  1. Ub Wijerathne C, Park H, Jeong H, Song J, Moon O, Seo Y, et al. Quisqualis indica Improves Benign Prostatic Hyperplasia by Regulating Prostate Cell Proliferation and Apoptosis. Biol Pharm Bull. 2017;40:2125-2133 pubmed publisher
    ..were treated with QI plus testosterone propionate (TP), and androgen receptor (AR) and prostate specific antigen (PSA) expression levels were assessed by Western blotting...
  2. de Andrade A, Arruda R, Torres M, Pieri N, Leite T, Celeghini E, et al. Nitric oxide in frozen-thawed equine sperm: Effects on motility, membrane integrity and sperm capacitation. Anim Reprod Sci. 2018;: pubmed publisher
    ..and other analyses [plasma and acrosomal membranes used the propidium iodide (PI) and Pisum sativum agglutinin (PSA), detection of tyrosine residues phosphorylation in the membrane (F0426), nitric oxide (DAF-2/DA), lipid ..
  3. Chen K, Sung S, Lin Y, Hsieh C, Shen K, Peng C, et al. Benign prostatic hyperplasia complicated with T1DM can be alleviated by treadmill exercise-evidences revealed by the rat model. BMC Urol. 2015;15:113 pubmed publisher
    ..As contrast, EX upregulated insulin, IGF, Ts, NO, 5αRd, AR, and DHT, and substantially reduced PSA. In BPH + DM + EX, EX maintained BW at a subnormal level, slightly suppressed prostate stromal inflammation,..
  4. Gómez Martín A, Martinez Gonzalez L, Puche Sanz I, Cozar J, Lorente J, Hernandez A, et al. GSTM1 gene expression and copy number variation in prostate cancer patients-Effect of chemical exposures and physical activity. Urol Oncol. 2019;37:290.e9-290.e15 pubmed publisher
    ..Individuals were classified in each group based on histological analysis of tissue biopsy, along with data on PSA level, Gleason score and T stage in patients with biopsies positive for CaP...
  5. Takuwa H, Tsuji W, Shintaku M, Yotsumoto F. Hormone signaling via androgen receptor affects breast cancer and prostate cancer in a male patient: A case report. BMC Cancer. 2018;18:1282 pubmed publisher
    ..revealed that the patient had cT3N0M0, stage III primary prostate cancer with a prostate-specific antigen (PSA) level of 40.5 ng/mL. Germline mutations in the BRCA1 and BRCA2 genes were not tested...
  6. Detering M, Steels E, Koyyalamudi S, Allifranchini E, Bocchietto E, Vitetta L. Ageratum conyzoides L. inhibits 5-alpha-reductase gene expression in human prostate cells and reduces symptoms of benign prostatic hypertrophy in otherwise healthy men in a double blind randomized placebo controlled clinical study. Biofactors. 2017;: pubmed publisher
    ..globulin (SHBG), Dehydroepiandrosterone sulfate (DHEA-S) and cortisol levels, and prostate specific antigen (PSA), lipids, blood glucose, the Aging Male's Symptom (AMS) Score and sexual function assessed by Derogatis Interview ..
  7. Smirnova S, Barilo A, Smolnikova M. [Hepatobiliary System Diseases as the Predictors of Psoriasis Progression]. Vestn Ross Akad Med Nauk. 2016;:102-8 pubmed
    ..matched by sex and age: Group 1--patients with psoriasis (PS, n = 77), group 2--patients with psoriatic arthritis (PsA, n = 98), group 3--control...
  8. Demark Wahnefried W, Nix J, Hunter G, Rais Bahrami S, Desmond R, Chacko B, et al. Feasibility outcomes of a presurgical randomized controlled trial exploring the impact of caloric restriction and increased physical activity versus a wait-list control on tumor characteristics and circulating biomarkers in men electing prostatectomy. BMC Cancer. 2016;16:61 pubmed publisher
    ..activated caspase-3, insulin and androgen receptors, VEGF, TNFβ, NFκB, and 4E-BP1), circulating biomarkers (PSA, insulin, glucose, VEGF, TNFβ, leptin, SHBG, and testosterone), lymphocytic gene expression of corresponding ..
  9. Seoane Mato D, Sánchez Piedra C, Silva Fernández L, Sivera F, Blanco F, Perez Ruiz F, et al. Prevalence of rheumatic diseases in adult population in Spain (EPISER 2016 study): Aims and methodology. Reumatol Clin. 2019;15:90-96 pubmed publisher
    ..The aim of this study is to estimate the prevalence of rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), osteoarthritis (knee, ..
  10. Wolke C, Teumer A, Endlich K, Endlich N, Rettig R, Stracke S, et al. Serum protease activity in chronic kidney disease patients: The GANI_MED renal cohort. Exp Biol Med (Maywood). 2017;242:554-563 pubmed publisher
    ..The data add to our understanding of pathomechanisms underlying development and progression of CKD and indicate that both enzymes might represent potential pharmacological targets for the preservation of renal function...
  11. Alonge S, Melandri M, Aiudi G, Lacalandra G. Advances in Prostatic Diagnostics in Dogs: The Role of Canine Prostatic Specific Esterase in the Early Diagnosis of Prostatic Disorders. Top Companion Anim Med. 2018;33:105-108 pubmed publisher
    ..biomarker to be included in a prostate health screening program, following the model of prostate-specific antigen (PSA) in human medicine...
  12. Henning S, Galet C, Gollapudi K, Byrd J, Liang P, Li Z, et al. Phase II prospective randomized trial of weight loss prior to radical prostatectomy. Prostate Cancer Prostatic Dis. 2018;21:212-220 pubmed publisher
    ..radical prostatectomy tissue, body weight, body mass index (BMI), waist to hip ratio, body composition, and serum PSA, insulin, triglyceride, cholesterol, testosterone, estradiol, leptin, adiponectin, interleukin 6, interleukin 8, ..
  13. Malemud C. Matrix Metalloproteinases and Synovial Joint Pathology. Prog Mol Biol Transl Sci. 2017;148:305-325 pubmed publisher
    ..in the destruction of articular cartilage in rheumatoid arthritis (RA), osteoarthritis (OA), psoriatic arthritis (PsA), and the spondyloarthropathies...
  14. Fujio K, Watanabe M, Ueki H, Li S, Kinoshita R, Ochiai K, et al. A vaccine strategy with multiple prostatic acid phosphatase-fused cytokines for prostate cancer treatment. Oncol Rep. 2015;33:1585-92 pubmed publisher
    ..effects of multiple PAP-fused cytokines in a mouse prostate cancer model bearing prostate-specific antigen (PSA)- and PAP-expressing tumors...
  15. Zhang W, Zhao R, Li X, Cui X, Zhao Z, Mao Y, et al. Effect of Yi-nao-jie-yu decoction on ?-aminobutyric acid type A receptor in the hippocampus and serum inflammatory factors in a rat model of poststroke anxiety. Neuropsychiatr Dis Treat. 2016;12:2827-2837 pubmed
    ..Chinese medicine and has been recently used as an important new therapeutic agent in poststroke anxiety (PSA)...
  16. Żołnierczyk A, Mączka W, Grabarczyk M, Wińska K, Woźniak E, Anioł M. Isoxanthohumol--Biologically active hop flavonoid. Fitoterapia. 2015;103:71-82 pubmed publisher
    ..It also inhibits the production of prostate specific antigen (PSA)...
  17. Fonager R, Zacho H, Langkilde N, Petersen L. (18)F-fluoride positron emission tomography/computed tomography and bone scintigraphy for diagnosis of bone metastases in newly diagnosed, high-risk prostate cancer patients: study protocol for a multicentre, diagnostic test accuracy study. BMC Cancer. 2016;16:10 pubmed publisher
    ..Eligibility criteria comprise the following: 1) biopsy-proven prostate cancer, 2) PSA ≥ 50 ng/ml (equals a prevalence of bone metastasis of ≈ 50% in the study population on bone ..
  18. Kleinclauss F, Thuret R, Murez T, Timsit M. [Urologic malignancies in renal transplant candidates and recipients]. Prog Urol. 2016;26:1094-1113 pubmed publisher
    ..Lymph nodes dissection needs to be discussed; systematic screening using PSA level and digital rectal examination should be offered in this specific population...
  19. Xiang B, Dong D, Shi N, Gao W, Yang Z, Cui Y, et al. PSA-responsive and PSMA-mediated multifunctional liposomes for targeted therapy of prostate cancer. Biomaterials. 2013;34:6976-91 pubmed publisher
    In the hormone-refractory stage of prostate cancer (PC), the expression of prostate-specific antigen (PSA) and prostate-specific membrane antigen (PSMA) often remains highly active...
  20. Sánchez B, Aguayo A, Martinez B, Rodríguez F, Marmolejo M, Svyryd Y, et al. Using Genetic and Epigenetic Markers to Improve Differential Diagnosis of Prostate Cancer and Benign Prostatic Hyperplasia by Noninvasive Methods in Mexican Patients. Clin Genitourin Cancer. 2018;16:e867-e877 pubmed publisher
    Prostate cancer (PCa) is the most common malignancy in Mexican men. Serum prostate-specific antigen (PSA) is the usual noninvasive biomarker used for its detection...
  21. Gómez Mejia A, Gámez G, Hirschmann S, Kluger V, Rath H, Bohm S, et al. Pneumococcal Metabolic Adaptation and Colonization Are Regulated by the Two-Component Regulatory System 08. mSphere. 2018;3: pubmed publisher
    ..Striking examples are genes for fatty acid biosynthesis, genes of the arginine deiminase system, and the psa operon encoding the manganese ABC transport system...
  22. Barquet A, Gelink A, Giannoudis P. Proximal femoral fractures and vascular injuries in adults: Incidence, aetiology and outcomes. Injury. 2015;46:2297-313 pubmed publisher
    ..with thrombosis, laceration with haemorrhage, and puncture or progressive erosion leading to a pseudoaneurysm (PSA) or arteriovenous fistula (AVF), with high prevalence for PSA, followed by lacerations...
  23. Ciccia F, Guggino G, Ferrante A, Raimondo S, Bignone R, Rodolico V, et al. Interleukin-9 Overexpression and Th9 Polarization Characterize the Inflamed Gut, the Synovial Tissue, and the Peripheral Blood of Patients With Psoriatic Arthritis. Arthritis Rheumatol. 2016;68:1922-31 pubmed publisher
    To investigate the expression and tissue distribution of Th9-related cytokines in patients with psoriatic arthritis (PsA)...
  24. Davis S, Martyn St James M, Sanderson J, Stevens J, Goka E, Rawdin A, et al. A systematic review and economic evaluation of bisphosphonates for the prevention of fragility fractures. Health Technol Assess. 2016;20:1-406 pubmed
    ..Probabilistic sensitivity analysis (PSA) and scenario analyses were used to assess uncertainty...
  25. Cindolo L, Ruggera L, Destefanis P, Dadone C, Ferrari G. Vaporize, anatomically vaporize or enucleate the prostate? The flexible use of the GreenLight laser. Int Urol Nephrol. 2017;49:405-411 pubmed publisher
    ..We evaluate 367 consecutive patients (mean age 69.1 years). Median prostate size and PSA were 68 ml (IQR 50-90) and 2.8 ng/ml (IQR 1.7-4.3), respectively...
  26. Yazdani N, Matthews Branch S. Daily subcutaneous testosterone for management of testosterone deficiency. Front Biosci (Elite Ed). 2018;10:334-343 pubmed
    ..hormone (FSH), dihydrotestosterone (DHT), dehydroepiandrosterone sulfate (DHEA-S), prostate-specific antigen (PSA), pregnenolone, and hemoglobin were determined...
  27. Xuan D, Chen G, Wang C, Yao X, Yin H, Zhang L, et al. A Cost-effectiveness Analysis of Rabbit Antithymocyte Globulin Versus Antithymocyte Globulin-fresenius as Induction Therapy for Patients With Kidney Transplantation From Donation After Cardiac Death in China. Clin Ther. 2018;40:1741-1751 pubmed publisher
    ..5%. Univariate sensitivity analysis and probability sensitivity analysis (PSA) were conducted to assess the impact of uncertainty of the variables on the results...
  28. Efstathiou E, Titus M, Wen S, Hoang A, Karlou M, Ashe R, et al. Molecular characterization of enzalutamide-treated bone metastatic castration-resistant prostate cancer. Eur Urol. 2015;67:53-60 pubmed publisher
    ..Maximal prostate-specific antigen (PSA) decline ≥ 50% and ≥ 90% occurred in 27 (45%) and 13 (22%) patients, respectively...
  29. Przepiera Bedzak H, Fischer K, Brzosko M. Serum Interleukin-18, Fetuin-A, Soluble Intercellular Adhesion Molecule-1, and Endothelin-1 in Ankylosing Spondylitis, Psoriatic Arthritis, and SAPHO Syndrome. Int J Mol Sci. 2016;17: pubmed publisher
    ..adhesion molecule-1 (sICAM-1), and endothelin-1 (ET-1) levels in ankylosing spondylitis (AS), psoriatic arthritis (PsA), and Synovitis Acne Pustulosis Hyperostosis Osteitis syndrome (SAPHO)...
  30. Campi R, Brookman May S, Subiela Henríquez J, Akdoğan B, Brausi M, Klatte T, et al. Impact of Metabolic Diseases, Drugs, and Dietary Factors on Prostate Cancer Risk, Recurrence, and Survival: A Systematic Review by the European Association of Urology Section of Oncological Urology. Eur Urol Focus. 2018;: pubmed publisher
    ..Moreover, most studies on PCa risk factors did not consider the impact of prostate-specific antigen (PSA) testing on PCa diagnosis...
  31. Lubrano E, Cantini F, Costanzo A, Girolomoni G, Prignano F, Olivieri I, et al. Measuring psoriatic disease in clinical practice. An expert opinion position paper. Autoimmun Rev. 2015;14:864-74 pubmed publisher
    ..Up to one third of patients with psoriasis are diagnosed with psoriatic arthritis (PsA)...
  32. Liu J, Liu B, Jing Y, Zhao G. Design, Synthesis and Biological Evaluation of Thiohydantoin Derivatives as Novel Anti-prostate Cancer Agents. Anticancer Agents Med Chem. 2016;16:740-6 pubmed
    ..were synthesized and evaluated for the abilities of inhibiting cell proliferation and prostate specific antigen (PSA) expression in prostate cancer cells...
  33. Belala R, Briand Amirat L, Vinciguerra L, Tainturier D, Kaidi R, Thorin C, et al. Effect of equilibration time on the motility and functional integrity of canine spermatozoa frozen in three different extenders. Res Vet Sci. 2016;106:66-73 pubmed publisher
    ..4%; SYBR14/IP: 63.6% vs 57.9% vs 64.8%); acrosome integrity (FITC-PSA: 79.4% vs 74% vs 76.2%) and DNA integrity (Acridine-orange: 98.9% vs 98.5% vs 98.7%) respectively for LDL vs...
  34. Bouzayani B, Meijide J, Pazos M, Elaoud S, Sanromán M. Removal of polyvinylamine sulfonate anthrapyridone dye by application of heterogeneous electro-Fenton process. Environ Sci Pollut Res Int. 2017;24:18309-18319 pubmed publisher
    ..Thus, this work investigates the removal of polyvinylamine sulfonate anthrapyridone (PSA) dye which complex structure makes difficult its degradation by conventional technologies...
  35. Vickers A, Savage C, Lilja H. Finasteride to prevent prostate cancer: should all men or only a high-risk subgroup be treated?. J Clin Oncol. 2010;28:1112-6 pubmed publisher
    ..We sought to determine whether prostate-specific antigen (PSA) levels could identify a high-risk subgroup for which the benefits of finasteride treatment outweigh the potential ..
  36. Renard Penna R, Roupret M, Compérat E, Rozet F, Granger B, Barkatz J, et al. Relationship between non-suspicious MRI and insignificant prostate cancer: results from a monocentric study. World J Urol. 2016;34:673-8 pubmed publisher
    ..Median PSA level was 7.15 ng/mL, with a median PSA density of 0.15...
  37. Nilsson E, Laursen K, Whitchurch J, McWilliam A, Ødum N, Persson J, et al. MiR137 is an androgen regulated repressor of an extended network of transcriptional coregulators. Oncotarget. 2015;6:35710-25 pubmed publisher
    ..Finally we show functional inhibition of miR137 function enhanced androgen induction of PSA/KLK3 expression...
  38. Wright J, Chéry L, Holt S, Lin D, Luedeke M, Rinckleb A, et al. Aspirin and NSAID use in association with molecular subtypes of prostate cancer defined by TMPRSS2:ERG fusion status. Prostate Cancer Prostatic Dis. 2016;19:53-6 pubmed publisher
    ..Logistic regression, controlling for age, race, PCa family history and PSA screening, was used to evaluate the association of T2E fusion status according to medication use...
  39. Hellgren K, Dreyer L, Arkema E, Glintborg B, Jacobsson L, Kristensen L, et al. Cancer risk in patients with spondyloarthritis treated with TNF inhibitors: a collaborative study from the ARTIS and DANBIO registers. Ann Rheum Dis. 2017;76:105-111 pubmed publisher
    ..here defined as ankylosing spondylitis (AS), undifferentiated spondarthropaties (SpA UNS), psoriatic arthritis (PsA)) are scarce...
  40. Ingrosso G, Trippa F, Maranzano E, Carosi A, Ponti E, Arcidiacono F, et al. Stereotactic body radiotherapy in oligometastatic prostate cancer patients with isolated lymph nodes involvement: a two-institution experience. World J Urol. 2017;35:45-49 pubmed publisher
    ..9 %) lesions and 5 × 8 Gy in 13 (27.7 %) lesions. Response to treatment was assessed with periodical PSA evaluation. Toxicity was registered according to RTOG/EORTC criteria. With a mean follow-up of 30...
  41. Fedtke C, Sha J, Thomas V, Ehrmann K, Bakaraju R. Impact of Spherical Aberration Terms on Multifocal Contact Lens Performance. Optom Vis Sci. 2017;94:197-207 pubmed publisher
    To investigate the impact of the primary (PSA) and secondary (SSA) spherical aberration terms on visual performance (VP) in presbyopes, as measured using multifocal (MFCL) soft contact lenses on eye. Seventeen presbyopes (age: 55.1 ± 6...
  42. van Dodewaard De Jong J, de Klerk J, Bloemendal H, Oprea Lager D, Hoekstra O, van den Berg H, et al. A randomised, phase II study of repeated rhenium-188-HEDP combined with docetaxel and prednisone versus docetaxel and prednisone alone in castration-resistant prostate cancer (CRPC) metastatic to bone; the Taxium II trial. Eur J Nucl Med Mol Imaging. 2017;44:1319-1327 pubmed publisher
    ..Primary endpoint was progression-free survival (PFS), defined as either PSA, radiographic or clinical progression. Patients were stratified by extent of bone metastases and hospital...
  43. Taha S, Gadalla S. Development of an efficient method for multi residue analysis of 160 pesticides in herbal plant by ethyl acetate hexane mixture with direct injection to GC-MS/MS. Talanta. 2017;174:767-779 pubmed publisher
    ..hexane (6:4) with a cleanup step using florisil/ PSA mixture...
  44. Barcelos A, Ambrósio C, Pereira Da Silva J, McKenna S, Wilburn J, Lopes Ferreira P. Psoriatic Arthritis Quality of Life questionnaire: translation, cultural adaptation and validation into Portuguese language. Rheumatol Int. 2018;38:249-254 pubmed publisher
    Psoriatic arthritis (PsA) has a strong negative impact on the quality of life of patients...
  45. Park H, Lee S, Song G, Kang T, Jung J, Chung H, et al. Diagnostic Performance of %[-2]proPSA and Prostate Health Index for Prostate Cancer: Prospective, Multi-institutional Study. J Korean Med Sci. 2018;33:e94 pubmed publisher
    ..Diagnostic accuracy of tPSA, free-to-total PSA ratio (%fPSA), p2PSA, %p2PSA, and the Beckman Coulter prostate health index (PHI) was assessed by receiver ..
  46. Quivrin M, Loffroy R, Cormier L, Mazoyer F, Bertaut A, Chambade D, et al. Multiparametric MRI and post implant CT-based dosimetry after prostate brachytherapy with iodine seeds: The higher the dose to the dominant index lesion, the lower the PSA bounce. Radiother Oncol. 2015;117:258-61 pubmed publisher
    ..post-implant MRI-based dosimetry of the Dominant Intra-prostatic Lesion (DIL) could best predict the occurrence of PSA bounce after prostate brachytherapy...
  47. Michaelis M, Leopold C. A measurement system analysis with design of experiments: Investigation of the adhesion performance of a pressure sensitive adhesive with the probe tack test. Int J Pharm. 2015;496:448-56 pubmed publisher
    The tack of a pressure sensitive adhesive (PSA) is not an inherent material property and strongly depends on the measurement conditions...
  48. Li C, Zhang Y, Yang C, Hao F, Chen S, Hao Q, et al. Intraventricular administration of endoneuraminidase-N facilitates ectopic migration of subventricular zone-derived neural progenitor cells into 6-OHDA lesioned striatum of mice. Exp Neurol. 2016;277:139-149 pubmed publisher
    Polysialic acid (PSA), a carbohydrate polymer associated with the neural cell adhesion molecule (NCAM), plays an important role in the migration, differentiation and maturation of neuroblasts...
  49. Cristea O, Lavallée L, Montroy J, Stokl A, Cnossen S, Mallick R, et al. Active surveillance in Canadian men with low-grade prostate cancer. CMAJ. 2016;188:E141-E147 pubmed publisher
    ..to the Ottawa regional Prostate Cancer Assessment Clinic with abnormal results for prostate-specific antigen (PSA) or prostate examination between Apr. 1, 2008, and Jan. 31, 2013...
  50. Tonry C, Leacy E, Raso C, Finn S, Armstrong J, Pennington S. The Role of Proteomics in Biomarker Development for Improved Patient Diagnosis and Clinical Decision Making in Prostate Cancer. Diagnostics (Basel). 2016;6: pubmed publisher
    ..Although increased expression of prostate-specific antigen (PSA) is an effective indicator for the recurrence of PCa, its intended use as a screening marker for PCa is of ..
  51. Arslan B, Onuk O, Hazar I, Aydin M, Cilesiz N, Eroglu A, et al. Prognostic value of endocan in prostate cancer: clinicopathologic association between serum endocan levels and biochemical recurrence after radical prostatectomy. Tumori. 2017;103:204-208 pubmed publisher
    ..who were referred to the urology outpatient clinic with normal rectal examination and prostate-specific antigen (PSA) levels. The patients' characteristics, baseline PSA value, and serum endocan levels were recorded...
  52. Lowenstein L, Mohile S, Gil H, Pandya C, Hemmerich J, Rodin M, et al. Which better predicts mortality among older men, a prostate cancer (PCa) diagnosis or vulnerability on the Vulnerable Elders Survey (VES-13)? A retrospective cohort study. J Geriatr Oncol. 2016;7:437-443 pubmed publisher
    ..9years and 76.1years, respectively. Of those with a PCa diagnosis, 74.6% had no active disease or a rising PSA only...
  53. Stavrinides V, Parker C, Moore C. When no treatment is the best treatment: Active surveillance strategies for low risk prostate cancers. Cancer Treat Rev. 2017;58:14-21 pubmed publisher
    Although the incidence of prostate cancer is rising due to PSA screening and increased life expectancy, the metastatic potential of low-grade, organ-confined disease remains low...
  54. Ghai S, van der Kwast T. Suspicious findings on micro-ultrasound imaging and early detection of prostate cancer. Urol Case Rep. 2018;16:98-100 pubmed publisher
    ..This prompted PSA testing, biopsy and eventual diagnosis of significant prostate cancer.
  55. Chen Z, Gulzar Z, St Hill C, Walcheck B, Brooks J. Increased expression of GCNT1 is associated with altered O-glycosylation of PSA, PAP, and MUC1 in human prostate cancers. Prostate. 2014;74:1059-67 pubmed publisher
    ..ELISA was used to measure core 2 O-linked glycan sialyl Lewis X (sLe(x) ) of prostate specific antigen (PSA), Mucin1 (MUC1), and prostatic acidic phosphatase (PAP) proteins...
  56. Wong L, Reers A, Currier H, Williams T, Cox M, Elliott J, et al. The Effects of the Organic Flame-Retardant 1,2-Dibromo-4-(1,2-dibromoethyl) Cyclohexane (TBECH) on Androgen Signaling in Human Prostate Cancer Cell Lines. J Biochem Mol Toxicol. 2016;30:239-42 pubmed publisher
    ..While γ-/δ-TBECH alone led to a significant increase in prostate-specific antigen (PSA) mRNA accumulation, both the α-/-TBECH and γ-/δ-TBECH mixtures repressed androgen-inducible PSA mRNA and protein ..
  57. Bucay N, Sekhon K, Yang T, Majid S, Shahryari V, Hsieh C, et al. MicroRNA-383 located in frequently deleted chromosomal locus 8p22 regulates CD44 in prostate cancer. Oncogene. 2017;36:2667-2679 pubmed publisher
    ..Importantly, we identified miR-383 as a novel PCa tissue diagnostic biomarker with a potential that outperforms that of serum PSA.
  58. Panter Brick C, Dajani R, Eggerman M, Hermosilla S, Sancilio A, Ager A. Insecurity, distress and mental health: experimental and randomized controlled trials of a psychosocial intervention for youth affected by the Syrian crisis. J Child Psychol Psychiatry. 2017;: pubmed publisher
    ..We tested the impacts of an 8-week programme of structured activities informed by a profound stress attunement (PSA) framework (Advancing Adolescents), delivered in group-format to 12-18 year-olds in communities heavily affected by ..
  59. Hatzichristodoulou G, Wagenpfeil S, Weirich G, Autenrieth M, Maurer T, Thalgott M, et al. Intraoperative frozen section monitoring during nerve-sparing radical prostatectomy: evaluation of partial secondary resection of neurovascular bundles and its effect on oncologic and functional outcome. World J Urol. 2016;34:229-36 pubmed publisher
    ..BCR was the oncologic endpoint (PSA ≥ 0.2 ng/ml)...
  60. Oji V, Luger T. The skin in psoriasis: assessment and challenges. Clin Exp Rheumatol. 2015;33:S14-9 pubmed
    The coexistence of psoriasis arthritis (PsA) and psoriasis vulgaris in about 20% of patients with psoriasis leads to a need for rheumatologic-dermatologic team work...
  61. Fallahi P, Ferrari S, Ruffilli I, Elia G, Miccoli M, Sedie A, et al. Increased incidence of autoimmune thyroid disorders in patients with psoriatic arthritis: a longitudinal follow-up study. Immunol Res. 2017;65:681-686 pubmed publisher
    ..about the prevalence of thyroid autoimmunity (AT) and dysfunction (TD) in patients with psoriatic arthritis (PsA)...
  62. Kavya K, Kumar M, Patil R, Hegde S, Kiran Kumar K, Nagesh R, et al. Differential expression of AP-1 transcription factors in human prostate LNCaP and PC-3 cells: role of Fra-1 in transition to CRPC status. Mol Cell Biochem. 2017;433:13-26 pubmed publisher
    ..Expression studies on AR, marker genes-PSA, TMPRSS2, and different AP-1 factors were analyzed by semi-quantitative RT-PCR and expressions of AR and Fra-1 ..
  63. Bautista Herrera L, De la Cruz Mosso U, Morales Zambrano R, Villanueva Quintero G, Hernández Bello J, Ramírez Dueñas M, et al. Expression of MIF and TNFA in psoriatic arthritis: relationship with Th1/Th2/Th17 cytokine profiles and clinical variables. Clin Exp Med. 2018;18:229-235 pubmed publisher
    Psoriatic arthritis (PsA) is an autoimmune inflammatory disease associated with psoriasis. The cause of this pathology is still unknown, but research suggests the diseases are caused by a deregulated cytokine production...
  64. Yilmaz H, Ciftci S, Yavuz U, Ustuner M, Saribacak A, Dillioglugil O. Percentage of free prostate-specific antigen (PSA) is a useful method in deciding to perform prostate biopsy with higher core numbers in patients with low PSA cut-off values. Kaohsiung J Med Sci. 2015;31:315-9 pubmed publisher
    ..of free prostate-specific antigen (%fPSA) cut-points in prostate cancer (PCa) detection in patients with total PSA (tPSA) levels between 2.5 ng/mL and 10.0 ng/mL...
  65. Mortezavi M, Thiele R, Ritchlin C. The joint in psoriatic arthritis. Clin Exp Rheumatol. 2015;33:S20-5 pubmed
    Psoriatic arthritis (PsA), a chronic inflammatory joint disease associated with psoriasis, is notable for diversity in disease presentation, course and response to treatment...
  66. Huang J, Reilly K, Zhang H, Wang H. Clinical evaluation of prostate cancer gene 3 score in diagnosis among Chinese men with prostate cancer and benign prostatic hyperplasia. BMC Urol. 2015;15:118 pubmed publisher
    ..Formalin-fixed, paraffin-embedded tissue blocks were used to test PCA3 and prostate-specific antigen (PSA) mRNA...
  67. Bewley A, Fowler J, Schöfer H, Kerrouche N, Rives V. Erythema of Rosacea Impairs Health-Related Quality of Life: Results of a Meta-analysis. Dermatol Ther (Heidelb). 2016;6:237-47 pubmed publisher
    ..Subjects with a patient self-assessment (PSA) of severe erythema of rosacea had a worse mean DLQI score than moderate PSA subjects (8.6 vs 6.0)...
  68. Xu X, Ryan C, Stuyckens K, Smith M, Saad F, Griffin T, et al. Modeling the Relationship Between Exposure to Abiraterone and Prostate-Specific Antigen Dynamics in Patients with Metastatic Castration-Resistant Prostate Cancer. Clin Pharmacokinet. 2017;56:55-63 pubmed publisher
    Recent analysis revealed strong associations between prostate-specific antigen (PSA) dynamics and overall survival (OS) in metastatic castration-resistant prostate cancer (mCRPC) and supported PSA dynamics as bridging surrogacy endpoints ..
  69. Lawal I, Ankrah A, Mokgoro N, Vorster M, Maes A, Sathekge M. Diagnostic sensitivity of Tc-99m HYNIC PSMA SPECT/CT in prostate carcinoma: A comparative analysis with Ga-68 PSMA PET/CT. Prostate. 2017;77:1205-1212 pubmed publisher
    ..The mean age of patients was 67.21?±?8.15 years and the median PSA level was 45.18?ng/mL (range?=?1.51-687?ng/mL)...
  70. Stoll K, Swift E, Fairbrother N, Nethery E, Janssen P. A systematic review of nonpharmacological prenatal interventions for pregnancy-specific anxiety and fear of childbirth. Birth. 2017;: pubmed publisher
    ..the number of publications that report on treatment options for pregnancy-specific anxiety and fear of childbirth (PSA/FoB), no systematic review of nonpharmacological prenatal interventions for PSA/FoB has been published...
  71. Pavani T, Rao K, Chakra C, Prabhu Y. Synthesis and characterization of γ-ferric oxide nanoparticles and their effect on Solanum lycopersicum. Environ Sci Pollut Res Int. 2016;23:9373-80 pubmed publisher
    ..transmission electron microscopy (TEM), vibrating sample magnetometry (VSM), and particle size analysis (PSA) to identify the purification step's influence on the structural, optical, morphological, magnetic, and particle ..
  72. Cornu J, Cancel Tassin G, Cox D, Roupret M, Koutlidis N, Bigot P, et al. Impact of Body Mass Index, Age, Prostate Volume, and Genetic Polymorphisms on Prostate-specific Antigen Levels in a Control Population. Eur Urol. 2016;70:6-8 pubmed publisher
    Prostate-specific antigen (PSA) is still the cornerstone of prostate cancer (PCa) screening and diagnosis in both research and current clinical practice...
  73. Hung J, Taylor A, Divine G, Hafron J, Hwang C. The Effect of Time to Castration Resistance on Outcomes With Abiraterone and Enzalutamide in Metastatic Prostate Cancer. Clin Genitourin Cancer. 2016;14:381-388 pubmed publisher
    ..026), respectively. However, the time to castration resistance was not an independent predictor of survival or the PSA response with novel AR-targeting therapy on multivariate analysis...
  74. Alberts A, Roobol M, Drost F, van Leenders G, Bokhorst L, Bangma C, et al. Risk-stratification based on magnetic resonance imaging and prostate-specific antigen density may reduce unnecessary follow-up biopsy procedures in men on active surveillance for low-risk prostate cancer. BJU Int. 2017;120:511-519 pubmed publisher
    ..the value of risk-stratification based on magnetic resonance imaging (MRI) and prostate-specific antigen density (PSA-D) in reducing unnecessary biopsies without missing Gleason pattern 4 prostate cancer in men on active surveillance ..
  75. Kanekura T, Seishima M, Honma M, Etou T, Eto H, Okuma K, et al. Therapeutic depletion of myeloid lineage leukocytes by adsorptive apheresis for psoriatic arthritis: Efficacy of a non-drug intervention for patients refractory to pharmacologics. J Dermatol. 2017;44:1353-1359 pubmed publisher
    Psoriatic arthritis (PsA), a chronic inflammatory arthropathy associated with psoriasis, is an intractable immune disorder and refractory to pharmacological intervention...
  76. Chen Y, Li J, Hu Y, Zhang H, Yang X, Jiang Y, et al. Multi-factors including Inflammatory/Immune, Hormones, Tumor-related Proteins and Nutrition associated with Chronic Prostatitis NIH IIIa+b and IV based on FAMHES project. Sci Rep. 2017;7:9143 pubmed publisher
    ..Further discriminant analysis revealed that ferritin (p = 0.002) and prostate-specific antigen (PSA) (p = 0.010) were significantly associated with NIH-IIIa and NIH-IV prostatitis, respectively...
  77. Kehr E, Masry P, Lis R, Loda M, Taplin M, Hirsch M. Detecting metastatic prostate carcinoma in pelvic lymph nodes following neoadjuvant hormone therapy: the eyes have it!. Histopathology. 2016;68:303-7 pubmed publisher
    ..alone or combined with leuprolide, were stained with antibodies against keratin AE1/AE3, prostate-specific antigen (PSA), prostate-specific acid phosphatase (PrAP), androgen receptor (AR), and NKX3.1...
  78. Baraliakos X, Coates L, Braun J. The involvement of the spine in psoriatic arthritis. Clin Exp Rheumatol. 2015;33:S31-5 pubmed
    Although different classification criteria have been developed for psoriatic arthritis (PsA) and spondyloarthritis (SpA), a clear distinction is still not always possible in daily practice...
  79. de Wit M, Campbell W, Coates L, Gladman D, James J, Lindsay C, et al. Let's Talk about Inclusion: A Report on Patient Research Partner Involvement in the GRAPPA 2015 Annual Meeting. J Rheumatol. 2016;43:970-3 pubmed publisher
    ..Arthritis (GRAPPA) have worked since 2012 to include the patient perspective in their psoriatic arthritis (PsA) research as well as in their annual meetings...
  80. DI Carlo M, Becciolini A, Lato V, Crotti C, Favalli E, Salaffi F. The 12-item Psoriatic Arthritis Impact of Disease Questionnaire: Construct Validity, Reliability, and Interpretability in a Clinical Setting. J Rheumatol. 2017;44:279-285 pubmed publisher
    ..of the 12-item Psoriatic Arthritis Impact of Disease (PsAID-12) questionnaire in patients with psoriatic arthritis (PsA). In 144 consecutive patients with PsA (81 men and 63 women, mean age of 51.4 ± 12...
  81. Liu Y, Liu Y, Yuan B, Yin L, Peng Y, Yu X, et al. FOXM1 promotes the progression of prostate cancer by regulating PSA gene transcription. Oncotarget. 2017;8:17027-17037 pubmed publisher
    Androgen/AR is the primary contributor to prostate cancer (PCa) progression by regulating Prostate Specific Antigen (PSA) gene transcription. The disease inevitably evolves to androgen-independent (AI) status...
  82. Westphal N, Theis T, Loers G, Schachner M, Kleene R. Nuclear fragments of the neural cell adhesion molecule NCAM with or without polysialic acid differentially regulate gene expression. Sci Rep. 2017;7:13631 pubmed publisher
    The neural cell adhesion molecule (NCAM) is the major carrier of polysialic acid (PSA) which modulates NCAM functions of neural cells at the cell surface...
  83. Halpern J, Oromendia C, Shoag J, Mittal S, Cosiano M, Ballman K, et al. Use of Digital Rectal Examination as an Adjunct to Prostate Specific Antigen in the Detection of Clinically Significant Prostate Cancer. J Urol. 2018;199:947-953 pubmed publisher
    ..These findings support the restriction of digital rectal examination to men with higher prostate specific antigen as a reflex test to improve specificity. It should not be used as a primary screening modality to improve sensitivity. ..
  84. Seitz A, Rauscher I, Haller B, Krönke M, Luther S, Heck M, et al. Preliminary results on response assessment using 68Ga-HBED-CC-PSMA PET/CT in patients with metastatic prostate cancer undergoing docetaxel chemotherapy. Eur J Nucl Med Mol Imaging. 2018;45:602-612 pubmed publisher
    ..A decrease in serum PSA level of ≥50% was defined as biochemical PR...
  85. Thorwarth D, Notohamiprodjo M, Zips D, Müller A. Personalized precision radiotherapy by integration of multi-parametric functional and biological imaging in prostate cancer: A feasibility study. Z Med Phys. 2017;27:21-30 pubmed publisher
    ..tumour load (cT3b cN0 cM0) indicated by subtotal involvement of prostate including the right seminal vesicle and by PSA-level >100...
  86. Pohle M, Magheli A, Fischer T, Kempkensteffen C, Busch J, Cash H, et al. The Effect of Evolving Strategies in the Surgical Management of Organ-Confined Prostate Cancer: Comparison of Data from 2005 to 2014 in a Multicenter Setting. Adv Ther. 2017;34:576-585 pubmed publisher
    ..Data from 44 German prostate cancer centers were included in the study. Patients' characteristics (age, initial PSA value), surgical techniques (open vs...
  87. Lundqvist J, Tringali C, Oskarsson A. Resveratrol, piceatannol and analogs inhibit activation of both wild-type and T877A mutant androgen receptor. J Steroid Biochem Mol Biol. 2017;174:161-168 pubmed publisher
    ..Further, we studied the effects of resveratrol, piceatannol and analogs on the levels of prostate-specific antigen (PSA) in LNCaP cells and found that all studied compounds decreased the level of PSA and that the synthetic analogs ..
  88. Agrawal N, Brown M. Genetic associations and functional characterization of M1 aminopeptidases and immune-mediated diseases. Genes Immun. 2014;15:521-7 pubmed publisher
    ..aminopeptidase 1 (ERAP1), endoplasmic reticulum aminopeptidase 2 (ERAP2) and puromycin-sensitive aminopeptidase (NPEPPS) are key zinc metallopeptidases that belong to the oxytocinase subfamily of M1 aminopeptidase family...
  89. Lebre M, Vieira P, Tang M, Aarrass S, Helder B, Newsom Davis T, et al. Synovial IL-21/TNF-producing CD4+ T cells induce joint destruction in rheumatoid arthritis by inducing matrix metalloproteinase production by fibroblast-like synoviocytes. J Leukoc Biol. 2017;101:775-783 pubmed publisher
    ..T cells in patients with RA was significantly higher compared with patients with psoriatic arthritis (PsA)...
  90. Zeng Q, Li H, Jiang H, Yu J, Wang Y, Ke H, et al. Tailoring polymeric hybrid micelles with lymph node targeting ability to improve the potency of cancer vaccines. Biomaterials. 2017;122:105-113 pubmed publisher
    ..copolymers, poly-(ethylene glycol) phosphorethanolamine (PEG-PE) and polyethylenimine-stearic acid conjugate (PSA) via hydrophobic and electrostatic interactions...
  91. Manara M, Caporali R, Favalli E, Grosso V, Atzeni F, Sarzi Puttini P, et al. Two-year retention rate of golimumab in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis: data from the LORHEN registry. Clin Exp Rheumatol. 2017;35:804-809 pubmed
    We aimed to provide data on golimumab real-life use in rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) from a multicentre observational registry of Northern Italy...
  92. Douven E, Kohler S, Rodriguez M, Staals J, Verhey F, Aalten P. Imaging Markers of Post-Stroke Depression and Apathy: a Systematic Review and Meta-Analysis. Neuropsychol Rev. 2017;27:202-219 pubmed publisher
    ..brain imaging markers have been studied in the development of post-stroke depression (PSD) and post-stroke apathy (PSA), but inconsistent associations have been reported...