Noxa

Summary

Gene Symbol: Noxa
Description: phorbol-12-myristate-13-acetate-induced protein 1
Alias: APR, NOXA, phorbol-12-myristate-13-acetate-induced protein 1, PMA-induced protein 1, adult T cell leukemia-derived PMA-responsive, immediate-early-response protein APR, protein Noxa
Species: human
Products:     Noxa

Top Publications

  1. Stankiewicz A, Livingstone A, Mohseni N, Mosser D. Regulation of heat-induced apoptosis by Mcl-1 degradation and its inhibition by Hsp70. Cell Death Differ. 2009;16:638-47 pubmed publisher
    ..Here we show that heat shock causes the loss of Mcl-1 protein. Depletion of Noxa by short hairpin RNA protected cells from hyperthermia by preventing Mcl-1 degradation...
  2. Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, et al. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science. 2000;288:1053-8 pubmed
    ..We report a previously unidentified pro-apoptotic gene, Noxa. Expression of Noxa induction in primary mouse cells exposed to x-ray irradiation was dependent on p53...
  3. Kim J, Ahn H, Ryu J, Suk K, Park J. BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha. J Exp Med. 2004;199:113-24 pubmed
    ..to find genes that are differentially expressed in hypoxia, we identified the BH3-only Bcl-2 family protein Noxa. Noxa is a candidate molecule mediating p53-induced apoptosis...
  4. Suzuki S, Nakasato M, Shibue T, Koshima I, Taniguchi T. Therapeutic potential of proapoptotic molecule Noxa in the selective elimination of tumor cells. Cancer Sci. 2009;100:759-69 pubmed publisher
    ..In the present study, we examined the potential of Noxa, a BH3-only protein with proapoptotic activity that functions downstream of the p53-mediated apoptotic pathway, to ..
  5. Wang Z, Sun Y. Identification and characterization of two splicing variants of human Noxa. Anticancer Res. 2008;28:1667-74 pubmed
    b>Noxa is a pro-apoptotic Bcl-2 homology 3 (BH3)-only containing protein. Here we report the identification of two splicing variants of the human Noxa gene, which consists of three exons and two introns...
  6. Rizzatti E, Mora Jensen H, Weniger M, Gibellini F, Lee E, Daibata M, et al. Noxa mediates bortezomib induced apoptosis in both sensitive and intrinsically resistant mantle cell lymphoma cells and this effect is independent of constitutive activity of the AKT and NF-kappaB pathways. Leuk Lymphoma. 2008;49:798-808 pubmed publisher
    ..At 10 nM, bortezomib induced the proapoptotic BH3-only protein Noxa in sensitive but not resistant cells...
  7. Chen L, Willis S, Wei A, Smith B, Fletcher J, Hinds M, et al. Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell. 2005;17:393-403 pubmed
    ..Bad, however, bound tightly to Bcl-2, Bcl-xL, and Bcl-w but only weakly to A1 and not to Mcl-1. Strikingly, Noxa bound only Mcl-1 and A1...
  8. Gutekunst M, Mueller T, Weilbacher A, Dengler M, Bedke J, Kruck S, et al. Cisplatin hypersensitivity of testicular germ cell tumors is determined by high constitutive Noxa levels mediated by Oct-4. Cancer Res. 2013;73:1460-9 pubmed publisher
    ..We identified Noxa as the only Bcl-2 family protein to be highly correlated with Oct-4 status and cisplatin sensitivity...
  9. Seo Y, Shin J, Ko K, Cha J, Park J, Lee B, et al. The molecular mechanism of Noxa-induced mitochondrial dysfunction in p53-mediated cell death. J Biol Chem. 2003;278:48292-9 pubmed
    ..Although Noxa, a "BH3-only" member of the Bcl-2 family, was shown to be a target of p53-mediated transactivation and to ..

More Information

Publications90

  1. Alves N, Derks I, Berk E, Spijker R, van Lier R, Eldering E. The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells. Immunity. 2006;24:703-16 pubmed
    ..after mitogenic activation, apart from expected protective Bcl-2 members, also rapidly upregulate the BH3-only protein Noxa in a p53-independent fashion...
  2. Obexer P, Geiger K, Ambros P, Meister B, Ausserlechner M. FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells. Cell Death Differ. 2007;14:534-47 pubmed
    ..FKHRL1 induced TRAIL and the BH3-only proteins Noxa and Bim, implicating both extrinsic and intrinsic death pathways...
  3. Willis S, Fletcher J, Kaufmann T, van Delft M, Chen L, Czabotar P, et al. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science. 2007;315:856-9 pubmed
    ..Our results indicate that BH3-only proteins induce apoptosis at least primarily by engaging the multiple pro-survival relatives guarding Bax and Bak. ..
  4. Zhang H, Guttikonda S, Roberts L, Uziel T, Semizarov D, Elmore S, et al. Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines. Oncogene. 2011;30:1963-8 pubmed publisher
    ..Furthermore, we show that Mcl-1 sequesters the BH3-only protein Noxa and Bim and the apoptotic effector Bak...
  5. Hijikata M, Kato N, Sato T, Kagami Y, Shimotohno K. Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line. J Virol. 1990;64:4632-9 pubmed
    ..This induction of the gene was not inhibited by an inhibitor of protein synthesis, cycloheximide. From these findings, we suggest that this gene, named APR, is a member of the cellular immediate-early-response genes.
  6. Zhang L, Lopez H, George N, Liu X, Pang X, Luo X. Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways. Cell Death Differ. 2011;18:864-73 pubmed publisher
    ..Among the 10 BH3-only proteins, Bid and Noxa were found to be critically involved in TRAIL-induced apoptosis, in which Noxa participates by constitutively ..
  7. Hagenbuchner J, Ausserlechner M, Porto V, David R, Meister B, Bodner M, et al. The anti-apoptotic protein BCL2L1/Bcl-xL is neutralized by pro-apoptotic PMAIP1/Noxa in neuroblastoma, thereby determining bortezomib sensitivity independent of prosurvival MCL1 expression. J Biol Chem. 2010;285:6904-12 pubmed publisher
    ..that the proteasome inhibitor bortezomib (PS-341, Velcade) activated the pro-apoptotic BH3-only proteins PMAIP1/Noxa and BBC3/Puma and induced accumulation of anti-apoptotic MCL1 as well as repression of anti-apoptotic BCL2L1/Bcl-xL...
  8. Wang Q, Mora Jensen H, Weniger M, Perez Galan P, Wolford C, Hai T, et al. ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells. Proc Natl Acad Sci U S A. 2009;106:2200-5 pubmed publisher
    ..EerI-induced cytotoxicity requires the up-regulation of the Bcl-2 homology3 (BH3)-only pro-apoptotic protein NOXA. We further demonstrate that both EerI and bortezomib activate NOXA via an unanticipated mechanism that ..
  9. Smith A, Dai H, Correia C, Takahashi R, Lee S, Schmitz I, et al. Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cells. J Biol Chem. 2011;286:17682-92 pubmed publisher
    Previous studies have suggested that the BH3 domain of the proapoptotic Bcl-2 family member Noxa only interacts with the anti-apoptotic proteins Mcl-1 and A1 but not Bcl-2...
  10. Elgendy M, Sheridan C, Brumatti G, Martin S. Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival. Mol Cell. 2011;42:23-35 pubmed publisher
    ..Ras-induced autophagy was associated with upregulation of the BH3-only protein Noxa as well as the autophagy regulator Beclin-1...
  11. Lowman X, McDonnell M, Kosloske A, Odumade O, Jenness C, Karim C, et al. The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose. Mol Cell. 2010;40:823-33 pubmed publisher
    The BH3-only protein, Noxa, is induced in response to apoptotic stimuli, such as DNA damage, hypoxia, and proteasome inhibition in most human cells...
  12. Brinkmann K, Zigrino P, Witt A, Schell M, Ackermann L, Broxtermann P, et al. Ubiquitin C-terminal hydrolase-L1 potentiates cancer chemosensitivity by stabilizing NOXA. Cell Rep. 2013;3:881-91 pubmed publisher
    The BH3-only protein NOXA represents one of the critical mediators of DNA-damage-induced cell death. In particular, its involvement in cellular responses to cancer chemotherapy is increasingly evident...
  13. Hauck P, Chao B, Litz J, Krystal G. Alterations in the Noxa/Mcl-1 axis determine sensitivity of small cell lung cancer to the BH3 mimetic ABT-737. Mol Cancer Ther. 2009;8:883-92 pubmed publisher
    ..Elevated Noxa and Bcl-2 levels directly correlated with sensitivity to ABT-737, whereas Mcl-1 levels were similar in all cell ..
  14. Craxton A, Butterworth M, Harper N, Fairall L, Schwabe J, Ciechanover A, et al. NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1. Cell Death Differ. 2012;19:1424-34 pubmed publisher
    ..We show that the unstructured BH3-only protein, NOXA, is degraded by an Ub-independent mechanism requiring 19S regulatory particle (RP) subunits of the 26S proteasome, ..
  15. Zaher M, Akrout I, Mirshahi M, Kolb J, Billard C. Noxa upregulation is associated with apoptosis of chronic lymphocytic leukemia cells induced by hyperforin but not flavopiridol. Leukemia. 2009;23:594-6 pubmed publisher
  16. Pang X, Zhang J, Lopez H, Wang Y, Li W, O Neill K, et al. The carboxyl-terminal tail of Noxa protein regulates the stability of Noxa and Mcl-1. J Biol Chem. 2014;289:17802-11 pubmed publisher
    The BH3-only protein Noxa is a critical mediator of apoptosis and functions primarily by sequestering/inactivating the antiapoptotic Bcl-2 family protein Mcl-1...
  17. Willis S, Chen L, Dewson G, Wei A, Naik E, Fletcher J, et al. Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev. 2005;19:1294-305 pubmed
    ..Accordingly, the BH3-only protein Noxa could bind to Mcl-1, displace Bak, and promote Mcl-1 degradation, but Bak-mediated cell death also required ..
  18. Flinterman M, Guelen L, Ezzati Nik S, Killick R, Melino G, Tominaga K, et al. E1A activates transcription of p73 and Noxa to induce apoptosis. J Biol Chem. 2005;280:5945-59 pubmed
    ..Importantly, expression of the 13S isoform of E1A substantially induced the p53 apoptotic target Noxa in several p53-deficient cancer cell lines...
  19. Nakajima W, Hicks M, Tanaka N, Krystal G, Harada H. Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small cell lung cancer. Cell Death Dis. 2014;5:e1052 pubmed publisher
    ..We have previously shown that the expression of Noxa, a BH3-only pro-apoptotic BCL-2 family protein, is the critical determinant of ABT-737 sensitivity...
  20. Lopez H, Zhang L, George N, Liu X, Pang X, Evans J, et al. Perturbation of the Bcl-2 network and an induced Noxa/Bcl-xL interaction trigger mitochondrial dysfunction after DNA damage. J Biol Chem. 2010;285:15016-26 pubmed publisher
    ..The pro-apoptotic members Bak, Bad, Bim, and Noxa were required for apoptosis induced by DNA damaging agents camptothecin and UV...
  21. Hassan M, Alaoui A, Feyen O, Mirmohammadsadegh A, Essmann F, Tannapfel A, et al. The BH3-only member Noxa causes apoptosis in melanoma cells by multiple pathways. Oncogene. 2008;27:4557-68 pubmed publisher
    ..In the present study, we examined gene transfer and expression of the proapoptotic BH3-only protein Noxa as an alternative approach to chemotherapy and investigated the molecular mechanisms regulating Noxa-induced ..
  22. Morales A, Gutman D, Lee K, Boise L. BH3-only proteins Noxa, Bmf, and Bim are necessary for arsenic trioxide-induced cell death in myeloma. Blood. 2008;111:5152-62 pubmed publisher
    ..ATO induced up-regulation of 3 proapoptotic BH3-only proteins (Noxa, Bmf, and Puma) and down-regulation of 2 antiapoptotic proteins Mcl-1 and Bcl-X(L)...
  23. Smit L, Hallaert D, Spijker R, de Goeij B, Jaspers A, Kater A, et al. Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity. Blood. 2007;109:1660-8 pubmed
    ..expression was not limited to protective changes but also included increased levels of proapoptotic BH3-only member Noxa. Here, we compare apoptosis gene profiles from peripheral blood B-CLL (n=15) with lymph node B-CLL (>90% CD5+/..
  24. Gomez Bougie P, Menoret E, Juin P, Dousset C, Pellat Deceunynck C, Amiot M. Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1/USP9X interaction. Biochem Biophys Res Commun. 2011;413:460-4 pubmed publisher
    ..Mcl-1 physically interacts with different BH3-only proteins; particularly, Noxa is involved in the modulation of Mcl-1 expression...
  25. Lynch J, Rajendran R, Xenaki G, Berrou I, Demonacos C, Krstic Demonacos M. The role of glucocorticoid receptor phosphorylation in Mcl-1 and NOXA gene expression. Mol Cancer. 2010;9:38 pubmed publisher
    ..putative Glucocorticoid Response Elements (GREs) within the promoter regulatory regions of the Bcl-2 family members NOXA and Mcl-1 indicating that they are direct GR transcriptional targets...
  26. Juliana P, Singh R, Singh P, Poland J, Bergstrom G, Huerta Espino J, et al. Genome-wide association mapping for resistance to leaf rust, stripe rust and tan spot in wheat reveals potential candidate genes. Theor Appl Genet. 2018;131:1405-1422 pubmed publisher
    ..Seedling and adult plant resistance (APR) to YR were associated with several markers at the distal end of chromosome 2AS...
  27. Anasir M, Baxter A, Poon I, Hulett M, Kvansakul M. Structural and Functional Insight into Canarypox Virus CNP058 Mediated Regulation of Apoptosis. Viruses. 2017;9: pubmed publisher
    ..cell pro-death Bcl-2 proteins, including Bak and Bax, as well as several BH3 only-proteins including Bim, Bid, Bmf, Noxa, Puma, and Hrk with high to moderate affinities...
  28. Realdon O, Rossetto F, Nalin M, Baroni I, Cabinio M, Fioravanti R, et al. Technology-enhanced multi-domain at home continuum of care program with respect to usual care for people with cognitive impairment: the Ability-TelerehABILITation study protocol for a randomized controlled trial. BMC Psychiatry. 2016;16:425 pubmed
    ..ClinicalTrials.gov ID: NCT02746484 (registration date: 12/apr/2016 - retrospectively registered).
  29. Suson K, Wolfe Christensen C, Elder J, Lakshmanan Y. Practice patterns and outcomes of pediatric partial nephrectomy in the United States: Comparison between pediatric urology and general pediatric surgery. J Pediatr Urol. 2015;11:171.e1-5 pubmed publisher
    ..included surgeon subspecialty, age, gender, 3Mâ„¢ All Patient Refined Diagnosis Related Groups (3Mâ„¢ APR DRG) code, severity level, mortality risk, length of stay (LOS), and medical/surgical complication flags...
  30. Yakovlev A, Di Giovanni S, Wang G, Liu W, Stoica B, Faden A. BOK and NOXA are essential mediators of p53-dependent apoptosis. J Biol Chem. 2004;279:28367-74 pubmed
    ..new protein synthesis, accumulation of p53 tumor suppressor protein, and p53-dependent induction of BOK and NOXA genes, while a role for BAX in this pathway is not essential...
  31. Hang W, Yin Z, Liu G, Zeng Q, Shen X, Sun Q, et al. Piperlongumine and p53-reactivator APR-246 selectively induce cell death in HNSCC by targeting GSTP1. Oncogene. 2018;37:3384-3398 pubmed publisher
    ..and induction of massive apoptosis-1) and its methylated analogue PRIMA-1Met (also called APR-246) were found to be able to reestablish the DNA-binding activity of p53 mutants and reinstate the functions of WT ..
  32. Blok R, Musters G, Borstlap W, Buskens C, Bemelman W, Tanis P. Snapshot Study on the Value of Omentoplasty in Abdominoperineal Resection with Primary Perineal Closure for Rectal Cancer. Ann Surg Oncol. 2018;25:729-736 pubmed publisher
    Perineal wound complications are often encountered following abdominoperineal resection (APR)...
  33. Alamri Y, Buchwald P, Dixon L, Dobbs B, Eglinton T, McCormick J, et al. Salvage surgery in patients with recurrent or residual squamous cell carcinoma of the anus. Eur J Surg Oncol. 2016;42:1687-1692 pubmed publisher
    ..23 Patients had a R0 resection. 18 Patients had an extended resection (16 R0) while 9 had a routine APR (7 R0). The 30-day post-operative mortality rate was 0%...
  34. Goom T, Malliaras P, Reiman M, Purdam C. Proximal Hamstring Tendinopathy: Clinical Aspects of Assessment and Management. J Orthop Sports Phys Ther. 2016;46:483-93 pubmed publisher
    ..The management outline presented aims to guide clinicians as well as future research. J Orthop Sports Phys Ther 2016;46(6):483-493. Epub 15 Apr 2016. doi:10.2519/jospt.2016.5986.
  35. Tani Y, Kondo N, Takagi D, Saito M, Hikichi H, Ojima T, et al. Combined effects of eating alone and living alone on unhealthy dietary behaviors, obesity and underweight in older Japanese adults: Results of the JAGES. Appetite. 2015;95:1-8 pubmed publisher
    ..Among men who exclusively ate alone, those who lived alone had a higher APR than men who lived with others...
  36. Dabrowska A, Kim N, Aldovini A. Tat-induced FOXO3a is a key mediator of apoptosis in HIV-1-infected human CD4+ T lymphocytes. J Immunol. 2008;181:8460-77 pubmed
    ..The FOXO3a target genes Fas ligand and TRAIL, involved in the extrinsic apoptotic pathway, and PUMA, Noxa, and Bim, which are part of the intrinsic apoptotic pathway, were also up-regulated, indicating that HIV infection ..
  37. Li J, Zhang W. How we do it: repair of large perineal hernia after abdominoperineal resection. Hernia. 2017;21:957-961 pubmed publisher
    Symptomatic perineal hernia is a rare complication after abdominoperineal resection (APR). Management of these hernias is challenging...
  38. Aubrey Bassler K, Cullen R, Simms A, Asghari S, Crane J, Wang P, et al. Outcomes of deliveries by family physicians or obstetricians: a population-based cohort study using an instrumental variable. CMAJ. 2015;187:1125-1132 pubmed publisher
    ..physicians and obstetricians at more than 20 weeks gestational age, with birth weight greater than 500 g, between Apr. 1, 2006, and Mar. 31, 2009...
  39. Jarauta V, Jaime P, Gonzalo O, De Miguel D, Ramírez Labrada A, Martinez Lostao L, et al. Inhibition of autophagy with chloroquine potentiates carfilzomib-induced apoptosis in myeloma cells in vitro and in vivo. Cancer Lett. 2016;382:1-10 pubmed publisher
    ..Carfilzomib induced apoptosis essentially by the intrinsic pathway, through the up-regulation of Puma and Noxa proteins followed by the interaction of Puma, Noxa and Bim with Bax and of Noxa with Bak...
  40. Pallis M, Burrows F, Ryan J, Grundy M, Seedhouse C, Abdul Aziz A, et al. Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cells. Oncotarget. 2017;8:16220-16232 pubmed publisher
    Direct co-operation between sensitiser molecules BAD and NOXA in mediating apoptosis suggests that therapeutic agents which sensitise to BAD may complement agents which sensitise to NOXA...
  41. Dinler C, Ulutas B, Voyvoda H, Ulutas P, Ural K, Karagenc T. Haptoglobin and serum amyloid-A concentrations and their relationship with oocyst count in neonatal lambs experimentally infected with Cryptosporidium parvum. Vet Parasitol. 2017;247:49-56 pubmed publisher
    This study aimed to evaluate the acute phase response (APR) through haptoglobin (Hp) and serum amyloid A (SAA) concentrations in serum and to examine the correlation between these acute phase proteins (APPs) and oocyst shedding using ..
  42. Mendy V, Vargas R, PAYTON M, Cannon Smith G. Association Between Consumption of Sugar-Sweetened Beverages and Sociodemographic Characteristics Among Mississippi Adults. Prev Chronic Dis. 2017;14:E137 pubmed publisher
    ..The likelihood of consuming SSBs at least once daily among respondents aged 18 to 34 years was 2.81 times higher (APR, 2.81; 95% CI, 2.49-3.18) than among those aged 65 years or older. The prevalence among men was 20% higher (APR, 1...
  43. Fahrioğlu U, Dodurga Y, Elmas L, Seçme M. Ferulic acid decreases cell viability and colony formation while inhibiting migration of MIA PaCa-2 human pancreatic cancer cells in vitro. Gene. 2016;576:476-82 pubmed publisher
    ..caspase-9, caspase-8, caspase-10, Bcl-2, BCL-XL,BID, DR4,DR5,FADD,TRADD,PARP, APAF, Bax, Akt, PTEN, PUMA, NOXA, MMP2, MMP9, TIMP1 and TIMP2 were determined by real-time PCR...
  44. Mi Y, Ren K, Pan H, Zhu L, Wu S, You X, et al. Flexible ureterorenoscopy (F-URS) with holmium laser versus extracorporeal shock wave lithotripsy (ESWL) for treatment of renal stone <2 cm: a meta-analysis. Urolithiasis. 2016;44:353-65 pubmed publisher
    ..35, 95 % confidence interval (CI) 1.65-3.34, P < 0.00001], lower auxiliary procedure rate (APR) [odds ratio (OR) 0.33, 95 % CI 0.22-0.50, P < 0.00001] and lower retreatment rate (RR) (OR 0...
  45. Clotet E, Martínez D, Moreno J, Tresanchez M, Palacín J. Assistant Personal Robot (APR): Conception and Application of a Tele-Operated Assisted Living Robot. Sensors (Basel). 2016;16: pubmed publisher
    ..This robotic concept has been named Assistant Personal Robot (or APR for short) and has been designed as a remotely telecontrolled robotic platform built to provide social and ..
  46. Beppu N, Kimura F, Aihara T, Doi H, Tomita N, Yanagi H, et al. Patterns of Local Recurrence and Oncologic Outcomes in T3 Low Rectal Cancer (?5 cm from the Anal Verge) Treated With Short-Course Radiotherapy With Delayed Surgery : Outcomes in T3 Low Rectal Cancer Treated With Short-Course Radiotherapy With Delayed. Ann Surg Oncol. 2017;24:219-226 pubmed publisher
    ..4 %) underwent intersphincteric resection (ISR), and 15 (12.6 %) underwent abdominoperineal resection (APR). Fifty-six patients (47.1 %) were ypT-downstaged, 86 (72.2 %) were ypN0, and 10 (8...
  47. Karpus O, Hsiao C, de Kort H, Tak P, Hamann J. Intracellular delivery of poly(I:C) induces apoptosis of fibroblast-like synoviocytes via an unknown dsRNA sensor. Biochem Biophys Res Commun. 2016;477:343-9 pubmed publisher
    ..of poly(I:C) induced significant cell death, accompanied by upregulation of pro-apoptotic proteins Puma and Noxa, caspase 3 cleavage, and nuclear segregation...
  48. Cook D, Mei W, Smith L, van Niekerk D, Ceballos K, Franco E, et al. Comparison of the Roche cobas® 4800 and Digene Hybrid Capture® 2 HPV tests for primary cervical cancer screening in the HPV FOCAL trial. BMC Cancer. 2015;15:968 pubmed publisher
    HPV FOCAL is a randomized trial (ISRCTN79347302, registered 20 Apr 2007) comparing high-risk (hr) HPV testing vs. liquid-based cytology (LBC) for cervical cancer screening of women aged 25-65...
  49. Dengler M, Weilbacher A, Gutekunst M, Staiger A, Vöhringer M, Horn H, et al. Discrepant NOXA (PMAIP1) transcript and NOXA protein levels: a potential Achilles' heel in mantle cell lymphoma. Cell Death Dis. 2014;5:e1013 pubmed publisher
    ..We here investigated the role of the Bcl-2 homology domain 3-only protein NOXA for life-death decision in MCL...
  50. Eitz Ferrer P, Potthoff S, Kirschnek S, Gasteiger G, Kastenmuller W, Ludwig H, et al. Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-?-dependent induction of pro-apoptotic Noxa. PLoS Pathog. 2011;7:e1002083 pubmed publisher
    ..Of the family of pro-apoptotic BH3-only proteins, only the loss of Noxa provided substantial protection, while the loss of Bim had a minor effect...
  51. Dube C, Mack D, Hunnicutt J, Lapane K. Cognitive Impairment and Pain Among Nursing Home Residents With Cancer. J Pain Symptom Manage. 2018;55:1509-1518 pubmed publisher
    ..Techniques to improve documentation and treatment of pain in nursing home residents with cognitive impairment are needed. ..
  52. Liu B, Sun R, Luo H, Liu X, Jiang M, Yuan C, et al. Both intrinsic and extrinsic apoptotic pathways are involved in Toll-like receptor 4 (TLR4)-induced cell death in monocytic THP-1 cells. Immunobiology. 2017;222:198-205 pubmed publisher
    ..TLR4 activation down-regulated the anti-apoptotic protein bcl-2, and up-regulated the pro-apoptotic proteins Noxa and Puma, suggesting that mitochondrial apoptotic pathway was also involved in LPS-induced cell death...
  53. Zhao H, Liu Q, Wang S, Dai F, Cheng X, Cheng X, et al. In vitro additive antitumor effects of dimethoxycurcumin and 5-fluorouracil in colon cancer cells. Cancer Med. 2017;6:1698-1706 pubmed publisher
    ..Increased production of ROS was accompanied by upregulation of CHOP and Noxa. Combination therapy of DMC and 5-Fu had increased efficacy on the above pathways compared with either drug alone...
  54. Qian C, Jin J, Chen J, Li J, Yu X, Mo H, et al. SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model. Mol Med Rep. 2017;16:9627-9635 pubmed publisher
    ..of the p53 downstream molecules including Bcl?associated X protein, P53 upregulated modulator of apoptosis, Noxa and BH3 interacting?domain death agonist were also investigated...
  55. Schneiders F, Huijts C, Reijm M, Bontkes H, Verheul H, de Gruijl T, et al. The effects of systemic treatment with aminobisphosphonates and statins on circulating V?9V?2-T cells in patients with advanced cancer. Immunobiology. 2018;223:171-177 pubmed publisher
    ..Frequently, patients undergoing NBP-treatment experience side-effects, known as acute phase response (APR), resulting from cytokine production by V?9V?2-T cells...
  56. Zhao Q, Fu C, Yu E, Zhang W, Meng R, Wang H, et al. [Study on the relationship between tumor regression grade and lymph node regression grade]. Zhonghua Wei Chang Wai Ke Za Zhi. 2017;20:1050-1054 pubmed
    ..Transabdominal low anterior resection (LAR) was performed in 118 cases and abdominal-perineal resection(APR) in 47 cases following the principle of total mesorectal excision (TME)...
  57. Case A, Bhavani S, Macharia G, Steffenson B. Genome-wide association study of stem rust resistance in a world collection of cultivated barley. Theor Appl Genet. 2018;131:107-126 pubmed publisher
    ..Research Service National Small Grains Collection was evaluated for adult plant resistance (APR) and seedling resistance to race TTKSK and APR to race QCCJB and the Pgt TTKSK composite of races TTKSK, TTKST, ..
  58. Sarkar H, Das S, Rissanen K, Sahoo P. First chemosensor for selective detection and quantification of L-4-Hydroxyproline in collagen and other bio samples. Anal Chem. 2017;: pubmed publisher
    Amino pyridine-based rhodamine conjugate (APR) has been developed as a first chemosensor for selective detection and quantification of L-4-Hydroxyproline (Hyp)...
  59. Boiani M, Daniel C, Liu X, Hogarty M, Marnett L. The stress protein BAG3 stabilizes Mcl-1 protein and promotes survival of cancer cells and resistance to antagonist ABT-737. J Biol Chem. 2013;288:6980-90 pubmed publisher
    ..These studies identify BAG3-mediated Mcl-1 stabilization as a potential target for cancer drug discovery. ..
  60. Geserick P, Wang J, Feoktistova M, Leverkus M. The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skin. Cell Death Dis. 2014;5:e1412 pubmed publisher
    ..Of note, ABT737 did not prime SCC cells to DR-induced apoptosis. Interestingly, the ratio of Mcl-1 and Noxa determined sensitivity to ABT737: loss of Mcl-1 rendered resistant cells sensitive to ABT737, whereas loss of Noxa ..
  61. Lin K, Chen J, Lin W, Lin X, Zhou Y, Zheng L, et al. [The clinical analysis of corneal interface fluid syndrome after Laser lamellar corneal refractive surgery]. Zhonghua Yan Ke Za Zhi. 2017;53:847-854 pubmed publisher
    ..b>Methods: During Dec. 2010 to Apr. 2016. In total 6 cases(9 eyes), 3 cases were bilateral, 3 cases were unilateral...
  62. Nakajima W, Sharma K, Lee J, Maxim N, Hicks M, Vu T, et al. DNA damaging agent-induced apoptosis is regulated by MCL-1 phosphorylation and degradation mediated by the Noxa/MCL-1/CDK2 complex. Oncotarget. 2016;7:36353-36365 pubmed publisher
    b>Noxa, a BH3-only pro-apoptotic BCL-2 family protein, causes apoptosis by specifically interacting with the anti-apoptotic protein MCL-1 to induce its proteasome-mediated degradation...
  63. Kapali A, Chandramohan K, Jayasudha A. A Prospective Study of Distal Microscopic Spread in Rectal Cancer After Neoadjuvant Chemoradiation in Pinned and Unpinned Specimen. Indian J Surg Oncol. 2017;8:469-473 pubmed publisher
    ..analytical study was conducted from May 2013 through February 2015 in 47 cases of carcinoma rectum (both AR and APR) who had received neoadjuvant CCRT...
  64. Park S, Jeong M, Jang S. In vitro binding properties of tumor suppressor p53 with PUMA and NOXA. Biochem Biophys Res Commun. 2012;420:350-6 pubmed publisher
    The p53-upregulated modulator of apoptosis (Puma) and Noxa, are direct targets in p53-mediated apoptosis localized to the mitochondria...
  65. Cillessen S, Hijmering N, Moesbergen L, Vos W, Verbrugge S, Jansen G, et al. ALK-negative anaplastic large cell lymphoma is sensitive to bortezomib through Noxa upregulation and release of Bax from Bcl-2. Haematologica. 2015;100:e365-8 pubmed publisher
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    ..Decreased expression of pro-apoptotic Bcl-2 family proteins (Noxa and Bid) and increased expression of anti-apoptotic proteins (Bcl-xL, Mcl-1 and XIAP) were observed after combined ..
  67. Yoon D, Bin S, Chan S, Chung C, In Y, Kim H, et al. Effectiveness and tolerability of transdermal buprenorphine patches: a multicenter, prospective, open-label study in Asian patients with moderate to severe chronic musculoskeletal pain. BMC Musculoskelet Disord. 2017;18:337 pubmed publisher
    ..ClinicalTrials.gov NCT01961271 . Registered 7 October 2013 (retrospectively registered; first patient was enrolled on 28 June 2013 and last patient last visit date was 26 Apr 2015).
  68. Ausserlechner M, Salvador C, Deutschmann A, Bodner M, Viola G, Bortolozzi R, et al. Therapy-resistant acute lymphoblastic leukemia (ALL) cells inactivate FOXO3 to escape apoptosis induction by TRAIL and Noxa. Oncotarget. 2013;4:995-1007 pubmed
    ..FOXO3 induces the death ligand TRAIL and the BH3-only protein Noxa implicating extrinsic as well as intrinsic death signaling...
  69. Perez Galan P, Roué G, Villamor N, Campo E, Colomer D. The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak. Blood. 2007;109:4441-9 pubmed
    ..low doses of this proteasome inhibitor, by neutralizing bortezomib-induced Mcl-1 accumulation and cooperating with Noxa to induce Bak displacement from this protein...
  70. de Frias M, Iglesias Serret D, Cosialls A, Coll Mulet L, Santidrian A, González Gironès D, et al. Akt inhibitors induce apoptosis in chronic lymphocytic leukemia cells. Haematologica. 2009;94:1698-707 pubmed publisher
    ..expression profile of genes involved in apoptosis, while A-443654 induced some changes, including an increase in NOXA and PUMA mRNA levels, suggesting the existence of additional targets for A-443654...
  71. Fang X, Lu G, Ha K, Lin H, Du Y, Zuo Q, et al. Acetylation of TIP60 at K104 is essential for metabolic stress-induced apoptosis in cells of hepatocellular cancer. Exp Cell Res. 2018;362:279-286 pubmed publisher
    ..suppressed the acetyltransferase activity of TIP60, and inhibited the expression of pro-apoptotic genes including NOXA and PUMA upon glucose starvation...
  72. Odani S, O Flaherty K, Veatch N, Tynan M, Agaku I. Attitudes toward smokeless tobacco use at all public sports venues among U.S. adults, 2016. Prev Med. 2018;111:397-401 pubmed publisher
    ..Among all adults, the likelihood of opposition was higher among females than males (Adjusted Prevalence Ratio [APR]=1.05; 95%CI=1.01-1.08) and increased with every 10-year increase in age (APR=1.01; 95%CI=1.00-1.02)...
  73. Sun H, Wang P, Zhang Q, He X, Zai G, Wang X, et al. MicroRNA‑21 expression is associated with the clinical features of patients with gastric carcinoma and affects the proliferation, invasion and migration of gastric cancer cells by regulating Noxa. Mol Med Rep. 2016;13:2701-7 pubmed publisher
    ..features, proliferation, invasion and migration of gastric cancer and the underlying mechanisms associated with Noxa. Reverse transcription quantitative polymerase chain reaction (RT‑qPCR) was performed to detect the ..
  74. Reilly K, Neaigus A, Jenness S, Wendel T, Marshall D, Hagan H. Experiences of Discrimination and HIV Risk Among Men Who Have Sex With Men in New York City. Am J Mens Health. 2016;10:505-514 pubmed
    ..7% reported being denied or given lower quality health care. HIV-positive status (adjusted PR [aPR] = 2.9; 95% CI = 1.5, 5.6) and drug use in the past 12 months (aPR = 0.3; 95% CI = 0.1, 0...
  75. Mardiguian S, Ladds E, Turner R, Shepherd H, Campbell S, Anthony D. The contribution of the acute phase response to the pathogenesis of relapse in chronic-relapsing experimental autoimmune encephalitis models of multiple sclerosis. J Neuroinflammation. 2017;14:196 pubmed publisher
    ..Acute brain injury models can be exacerbated by augmenting the hepatic acute phase response (APR). Here, we explored the contribution of the hepatic APR to relapse in two rodent models of MS...
  76. Zang X, Qi X. Association Between PM2.5 Exposure and the Prognosis of Patients with Acute Myocardial Infraction. Arch Med Res. 2017;48:292-296 pubmed publisher
    ..analysis of a total of 598 patients with AMI in TEDA International Cardiovascular Hospital, from Oct 28th, 2013-Apr 30th 2014. All patients were divided into five groups according to the National Air Quality Classification Standard...
  77. van Breda S, Claessen S, van Herwijnen M, Theunissen D, Jennen D, de Kok T, et al. Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018;393:160-170 pubmed publisher
    ..Overall, our integrative data analyses identified novel genes modulated by VPA, which provide more insight into the mechanisms of repeated dose toxicity of VPA, leading to steatosis. ..
  78. Bailey R, Adera F, Mackesy Amiti M, Adipo T, Nordstrom S, Mehta S, et al. Prospective comparison of two models of integrating early infant male circumcision with maternal child health services in Kenya: The Mtoto Msafi Mbili Study. PLoS ONE. 2017;12:e0184170 pubmed publisher
    ..We report adjusted prevalence ratios (aPR)...
  79. Pilchova I, Klacanova K, Dibdiakova K, Saksonova S, Stefániková A, Vidomanová E, et al. Proteasome Stress Triggers Death of SH-SY5Y and T98G Cells via Different Cellular Mechanisms. Neurochem Res. 2017;42:3170-3185 pubmed publisher
    ..caspase 3 in SH-SY5Y cells that was probably a result of increased expression of pro-apoptotic proteins, PUMA and Noxa. In T98G cells, bortezomib-induced expression of caspase 4, documented after 24 h of treatment, with further ..
  80. Park J, Han J, Myung S, Seo Y, Kim T. MTD-like motif of a BH3-only protein, BNIP1, induces necrosis accompanied by an intracellular calcium spike. Biochem Biophys Res Commun. 2018;495:1661-1667 pubmed publisher
    The mitochondrial targeting domain (MTD) of Noxa has necrosis-inducing activity when conjugated with cell-penetrating peptide (CPP)...
  81. Cook S, Stuart K, Gilley R, Sale M. Control of cell death and mitochondrial fission by ERK1/2 MAP kinase signalling. FEBS J. 2017;284:4177-4195 pubmed publisher
    ..However, ERK1/2 can also drive the expression of the prodeath protein NOXA to control 'autophagy or apoptosis' decisions during nutrient starvation...