NOTCH2

Summary

Gene Symbol: NOTCH2
Description: notch 2
Alias: AGS2, HJCYS, hN2, neurogenic locus notch homolog protein 2, Notch homolog 2
Species: human

Top Publications

  1. ncbi The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation
    C Larsson
    Department of Clinical Genetics, Karolinska Hospital, Stockholm, Sweden
    Genomics 24:253-8. 1994
  2. pmc Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2
    K Shimizu
    Departments of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Japan
    Mol Cell Biol 20:6913-22. 2000
  3. ncbi Notch sensitivity of titanium alloy, commercially pure titanium, and stainless steel spinal implants
    J C Dick
    Midwest Orthopaedic Research Foundation, Minneapolis, Minnesota, USA
    Spine (Phila Pa 1976) 26:1668-72. 2001
  4. ncbi The Tat protein of the human immunodeficiency virus type 1 (HIV-1) interacts with the EGF-like repeats of the Notch proteins and the EGF precursor
    Nitza Shoham
    Department of Human Microbiology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Virus Res 98:57-61. 2003
  5. doi A clinically relevant in vitro model for evaluating the effects of aerosolized vesicants
    Claudia Karacsonyi
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, United States
    Toxicol Lett 185:38-44. 2009
  6. pmc Constitutive expression of the AP-1 transcription factors c-jun, junD, junB, and c-fos and the marginal zone B-cell transcription factor Notch2 in splenic marginal zone lymphoma
    Gunhild Trøen
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello N 0310, Oslo, Norway
    J Mol Diagn 6:297-307. 2004
  7. pmc Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site
    Yuefeng Tang
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME 04074, USA
    Circ Res 102:661-8. 2008
  8. pmc Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL
    Cristina Del Bianco
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 5:e15034. 2010
  9. ncbi F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation
    Qi Dong Hu
    Department of Clinical Research, Singapore General Hospital, 169608, Singapore, Singapore
    Cell 115:163-75. 2003
  10. pmc Whole-genome sequencing identifies recurrent somatic NOTCH2 mutations in splenic marginal zone lymphoma
    Mark J Kiel
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Exp Med 209:1553-65. 2012

Research Grants

  1. The role of ADAM10 in B cell development and humoral immunity
    NATALIA SOL CHAIMOWITZ; Fiscal Year: 2013
  2. Molecular mechanisms of Bile Duct Proliferation in Mice with Glycosylation Defect
    MATTHEW JOSEPH RYAN; Fiscal Year: 2012
  3. Molecular Mechanisms Underlying the Distinct Functions of Notch1 and Notch2
    Matthew R Hass; Fiscal Year: 2010
  4. Ernesto Canalis; Fiscal Year: 2016
  5. Nadean L Brown; Fiscal Year: 2016
  6. Robert S Haltiwanger; Fiscal Year: 2016
  7. Ulf Klein; Fiscal Year: 2014
  8. MECHANISM OF CYCLOPHOSPHAMIDE TOXICITY
    JAMES KEHRER; Fiscal Year: 1999
  9. INTERACTION OF AMINOTHIOLS AND ALKYLATING AGENTS
    Frederick Valeriote; Fiscal Year: 1990
  10. Timothy W King; Fiscal Year: 2016

Detail Information

Publications252 found, 100 shown here

  1. ncbi The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation
    C Larsson
    Department of Clinical Genetics, Karolinska Hospital, Stockholm, Sweden
    Genomics 24:253-8. 1994
    ..to human metaphase chromosomes, and the results, combined with data from somatic cell hybrid panels, show that the NOTCH2 and 3 genes are located at positions 1p13-p11 and 19p13.2-p13...
  2. pmc Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2
    K Shimizu
    Departments of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Japan
    Mol Cell Biol 20:6913-22. 2000
    ..In this report, we investigated these issues for Notch2. All of the three DSL proteins bound to endogenous Notch2 on the surface of BaF3 cells, although characteristics ..
  3. ncbi Notch sensitivity of titanium alloy, commercially pure titanium, and stainless steel spinal implants
    J C Dick
    Midwest Orthopaedic Research Foundation, Minneapolis, Minnesota, USA
    Spine (Phila Pa 1976) 26:1668-72. 2001
    ..This is a biomechanical study comparing the fatigue life of stainless steel (SS), titanium alloy (TI), and commercially pure titanium (CP) rods that were notched using techniques essential to spine surgery...
  4. ncbi The Tat protein of the human immunodeficiency virus type 1 (HIV-1) interacts with the EGF-like repeats of the Notch proteins and the EGF precursor
    Nitza Shoham
    Department of Human Microbiology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Virus Res 98:57-61. 2003
    ..virus (HIV) was shown to interact with a region spanning the EGF-like repeats 1-6 of the mouse Notch1, the human Notch2 and the Drosophila Notch...
  5. doi A clinically relevant in vitro model for evaluating the effects of aerosolized vesicants
    Claudia Karacsonyi
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, United States
    Toxicol Lett 185:38-44. 2009
    ..of exposure of differentiated human respiratory epithelial cells in air-liquid interface to mechlorethamine (HN2), an HD functional analog...
  6. pmc Constitutive expression of the AP-1 transcription factors c-jun, junD, junB, and c-fos and the marginal zone B-cell transcription factor Notch2 in splenic marginal zone lymphoma
    Gunhild Trøen
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello N 0310, Oslo, Norway
    J Mol Diagn 6:297-307. 2004
    ..The AP-1 transcription factors c-jun, junD, junB, and c-fos as well as Notch2 were found to be specifically up-regulated...
  7. pmc Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site
    Yuefeng Tang
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME 04074, USA
    Circ Res 102:661-8. 2008
    ..Using primary human smooth muscle cells, we show that expression of the constitutive active ICD of human Notch1, Notch2, or Notch4 receptors increase SMA levels...
  8. pmc Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL
    Cristina Del Bianco
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 5:e15034. 2010
    ....
  9. ncbi F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation
    Qi Dong Hu
    Department of Clinical Research, Singapore General Hospital, 169608, Singapore, Singapore
    Cell 115:163-75. 2003
    ..This can be blocked by dominant negative Notch1, Notch2, and two Deltex1 mutants lacking the RING-H2 finger motif, but not by dominant-negative RBP-J or Hes1 antisense ..
  10. pmc Whole-genome sequencing identifies recurrent somatic NOTCH2 mutations in splenic marginal zone lymphoma
    Mark J Kiel
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Exp Med 209:1553-65. 2012
    ..In particular, we identified recurrent somatic gain-of-function mutations in NOTCH2, a gene encoding a protein required for marginal zone B cell development, in 25 of 99 (∼25%) cases of SMZL and ..
  11. ncbi Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
    C M Blaumueller
    Department of Cell Biology and Biology, Boyer Center for Molecular Medicine, Yale University, New Haven, Connecticut 06536 0812, USA
    Cell 90:281-91. 1997
    ..We provide evidence that these fragments are tethered together on the plasma membrane by a link that is sensitive to reducing conditions, forming a heterodimeric receptor...
  12. ncbi Notch signaling: cell fate control and signal integration in development
    S Artavanis-Tsakonas
    Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Science 284:770-6. 1999
    ..Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis...
  13. ncbi MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors
    L Wu
    Department of Adult Oncology, Dana Farber Cancer Institute and Departments of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 26:484-9. 2000
    ..These studies provide a molecular mechanism to explain the genetic links between mastermind and Notch in Drosophila and indicate that MAML1 functions as a transcriptional co-activator for NOTCH signalling...
  14. ncbi Notch signaling induces cell cycle arrest in small cell lung cancer cells
    V Sriuranpong
    Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Res 61:3200-5. 2001
    ..Recombinant adenoviruses were used to overexpress active forms of Notch1, Notch2, or the Notch effector protein human hairy enhancer of split-1 (HES1) in DMS53 and NCI-H209 SCLC cells...
  15. ncbi Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways
    Lluis Espinosa
    Centre Oncologia Molecular, Institut de Recerca Oncologica, Hospitalet, Barcelona 08907, Spain
    J Biol Chem 278:32227-35. 2003
    ..In this study, we show that GSK-3 beta is able to bind and phosphorylate Notch2 in vitro and in vivo...
  16. ncbi Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells
    Franziska Jundt
    Department of Hematology and Oncology, Charite, Campus Virchow Klinikum, University Medicine Berlin, Berlin, Germany
    Blood 103:3511-5. 2004
    ..Functional data indicate that ligand-induced Notch signaling is a growth factor for MM cells and suggest that these interactions contribute to myelomagenesis in vivo...
  17. ncbi The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer
    C Parr
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff CF4 4XN, UK
    Int J Mol Med 14:779-86. 2004
    ..These results support the notion that suppression of Notch-1 activity may represent a novel therapeutic strategy...
  18. ncbi Structural basis for autoinhibition of Notch
    Wendy R Gordon
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 77 Ave Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Struct Mol Biol 14:295-300. 2007
    ..We present here the X-ray structure of the human NOTCH2 NRR, which adopts an autoinhibited conformation...
  19. pmc Loss of NOTCH2 positively predicts survival in subgroups of human glial brain tumors
    Jean Louis Boulay
    Laboratory of Molecular Neuro Oncology, Department of Research, University Hospital, Basel, Switzerland
    PLoS ONE 2:e576. 2007
    ..We found that loss of 1p centromeric marker D1S2696 within NOTCH2 intron 12 was associated with favorable prognosis in OD (P = 0.0007) as well as in GBM (P = 0...
  20. pmc Notch2 signaling induces apoptosis and inhibits human MDA-MB-231 xenograft growth
    Christine F O'Neill
    Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Dr, Scarborough, ME 04076, USA
    Am J Pathol 171:1023-36. 2007
    Notch functions as an oncogene or tumor inhibitor in various cancers, and decreases in Notch2 expression are associated with increasing grade of human breast cancer...
  21. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
    ..2 x 10(-10)), TSPAN8-LGR5 (P = 1.1 x 10(-9)), THADA (P = 1.1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions...
  22. doi NOTCH2 mutations in marginal zone lymphoma
    Gunhild Trøen
    Haematologica 93:1107-9. 2008
  23. pmc Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes
    Niels Grarup
    Steno Diabetes Center, Copenhagen, Denmark
    Diabetes 57:2534-40. 2008
    ..variants in the JAZF1 (rs864745), CDC123/CAMK1D (rs12779790), TSPAN8 (rs7961581), THADA (rs7578597), ADAMTS9 (rs4607103), and NOTCH2 (rs10923931) loci, which were recently identified by meta-analysis of genome-wide association data.
  24. pmc Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk
    Hana Lango
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Diabetes 57:3129-35. 2008
    ..Here, we assess the ability of 18 confirmed type 2 diabetes variants to differentiate between type 2 diabetic case and control subjects...
  25. pmc Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes
    Harald Staiger
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tubingen, Tubingen, Germany
    PLoS ONE 3:e3019. 2008
    ..e., obesity, impaired insulin secretion, and insulin resistance...
  26. pmc Genotype score in addition to common risk factors for prediction of type 2 diabetes
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 359:2208-19. 2008
    ..We tested the hypothesis that knowledge of these loci allows better prediction of risk than knowledge of common phenotypic risk factors alone...
  27. doi Clinical risk factors, DNA variants, and the development of type 2 diabetes
    Valeriya Lyssenko
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    N Engl J Med 359:2220-32. 2008
    ..Type 2 diabetes mellitus is thought to develop from an interaction between environmental and genetic factors. We examined whether clinical or genetic factors or both could predict progression to diabetes in two prospective cohorts...
  28. doi Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study
    X Lin
    Discovery Analytics, GlaxoSmithKline, Collegeville, PA, USA
    Diabetologia 52:600-8. 2009
    ....
  29. doi Tenascin-C is a novel RBPJkappa-induced target gene for Notch signaling in gliomas
    Balasubramanian Sivasankaran
    Department of Research, Laboratory of Molecular Neuro Oncology, University Hospital, Basel, Switzerland
    Cancer Res 69:458-65. 2009
    ..In these malignant gliomas as well as in GBM cell lines, we found Notch2 protein to be strongly expressed...
  30. pmc A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)
    Gilles Thomas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Nat Genet 41:579-84. 2009
    ..10(-10) adjusted genotype test, 2 degrees of freedom) resides in a large linkage disequilibrium block neighboring NOTCH2 and FCGR1B; this signal was stronger for estrogen-receptor-positive tumors. A second SNP on chromosome 14q24...
  31. ncbi Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma
    Suk young Lee
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo 113 8655, Japan
    Cancer Sci 100:920-6. 2009
    ..b>Notch2, another member of the Notch gene family, is preferentially expressed in mature B cells and is essential for ..
  32. pmc Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men
    Alena Stancakova
    Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Diabetes 58:2129-36. 2009
    ..We investigated the effects of 18 confirmed type 2 diabetes risk single nucleotide polymorphisms (SNPs) on insulin sensitivity, insulin secretion, and conversion of proinsulin to insulin...
  33. doi Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis
    Bertrand Isidor
    CHU Nantes, Service de Genetique Medicale, Nantes, France
    Nat Genet 43:306-8. 2011
    ..of six unrelated individuals with this syndrome and identified heterozygous nonsense and frameshift mutations in NOTCH2 in five of them...
  34. doi Expression patterns of Notch receptors and their ligands Jagged and Delta in human placenta
    F Herr
    Department of Obstetrics and Gynecology, University of Greifswald, Greifswald, Germany
    Placenta 32:554-63. 2011
    ..The receptors Notch2, -3, -4 and their ligands Jagged1, -2 and Delta1, -4 were detected at both the mRNA and protein level in early and ..
  35. pmc Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma
    Nicholas J Wang
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 108:17761-6. 2011
    ..We identified NOTCH1 or NOTCH2 mutations in ~75% of cutaneous SCCs and in a lesser fraction of lung SCCs, defining a spectrum for the most ..
  36. doi Profiling immunohistochemical expression of NOTCH1-3, JAGGED1, cMET, and phospho-MAPK in 100 carcinomas of unknown primary
    Dimitrios Krikelis
    Department of Medical Oncology, Medical School, Aristotle University of Thessaloniki, Papageorgiou Hospital, Thessaloniki, Greece
    Clin Exp Metastasis 29:603-14. 2012
    ..001). Our study points to the MAPK and cMET axes as crucial in defining cancer progression and outcome in CUP patients and, if validated, could justify attempts at their therapeutic modulation...
  37. pmc The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development
    Davide Rossi
    Division of Hematology and 9 Laboratory of Medical Informatics, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, 28100 Novara, Italy
    J Exp Med 209:1537-51. 2012
    ..Mutations in NOTCH2, a gene required for marginal-zone (MZ) B cell development, represent the most frequent lesion in SMZL, accounting ..
  38. pmc The different role of Notch1 and Notch2 in astrocytic gliomas
    Peng Xu
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, People s Republic of China
    PLoS ONE 8:e53654. 2013
    ..However, in our previous study, we found that Notch1 was overexpressed while Notch2 downregulated in the majority of astrocytic gliomas with different grades as well as in glioblastoma cell lines ..
  39. pmc Notch2 controls prolactin and insulin-like growth factor binding protein-1 expression in decidualizing human stromal cells of early pregnancy
    Gerlinde R Otti
    Department of Obstetrics and Fetal Maternal Medicine, Reproductive Biology Unit, Medical University of Vienna, Vienna, Austria
    PLoS ONE 9:e112723. 2014
    ..Immunofluorescence of first trimester decidual tissues revealed expression of Notch2 receptor and its putative, membrane-anchored interaction partners Jagged1, Delta-like (DLL) 1 and DLL4 in stromal ..
  40. ncbi Paralogy mapping: identification of a region in the human MHC triplicated onto human chromosomes 1 and 9 allows the prediction and isolation of novel PBX and NOTCH loci
    N Katsanis
    Department of Biochemistry and Molecular Genetics, Imperial College of Medicine at St Mary s, London, W2 1PG, United Kingdom
    Genomics 35:101-8. 1996
    ....
  41. ncbi Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease
    O Berezovska
    Alzheimer Research Unit, Massachusetts General Hospital, Charlestown 02129, USA
    J Neuropathol Exp Neurol 57:738-45. 1998
    ..We found that Notch1, Notch2, and a Notch ligand, Jagged1, are expressed in adult brain in mouse and in human, with strongest expression in the ..
  42. ncbi Associations between Notch-2, Akt-1 and HER2/neu expression in invasive human breast cancer: a tissue microarray immunophenotypic analysis on 98 patients
    Ada Maria Florena
    Dipartimento di Patologia Umana, Universita degli Studi di Palermo, Palermo, Italia
    Pathobiology 74:317-22. 2007
    ..We aimed to investigate the existence of associations between well-established and newly recognized biological and phenotypic features of breast cancer involved in tumor progression and prognosis...
  43. doi Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias
    Sung Hak Lee
    Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea
    APMIS 115:1357-63. 2007
    NOTCH proteins (NOTCH1, NOTCH2, NOTCH3 and NOTCH4) play crucial roles in embryonic development. Also, mounting evidence indicates that NOTCH contributes to the pathogenesis of hematopoietic and solid malignancies...
  44. pmc NOTCH2 is neither rearranged nor mutated in t(1;19) positive oligodendrogliomas
    Magdalena Benetkiewicz
    INSERM, Unité 830, Paris, France
    PLoS ONE 4:e4107. 2009
    ..Recent studies of 1p/19q co-deleted OD suggest that the NOTCH2 gene is implicated in oligodendrocyte differentiation and may be involved in this rearrangement...
  45. doi Testing the association of novel meta-analysis-derived diabetes risk genes with type II diabetes and related metabolic traits in Asian Indian Sikhs
    Dharambir K Sanghera
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Hum Genet 54:162-8. 2009
    A recent meta-analysis on three genome-wide association (GWA) scans identified six loci (NOTCH2, THADA, ADAMTS9, JAZF1, CDC123/CAMKID and TSPAN8/LGRS) highly associated with type II diabetes (T2D) in Caucasians...
  46. doi Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss
    Michael A Simpson
    Division of Genetics and Molecular Medicine, King s College London School of Medicine, Guy s Hospital, London, UK
    Nat Genet 43:303-5. 2011
    We used an exome-sequencing strategy and identified an allelic series of NOTCH2 mutations in Hajdu-Cheney syndrome, an autosomal dominant multisystem disorder characterized by severe and progressive bone loss...
  47. doi Notch2 and immune function
    Mamiko Sakata-Yanagimoto
    Department of Hematology, Faculty of Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Curr Top Microbiol Immunol 360:151-61. 2012
    b>Notch2 is expressed in many cell types of most lineages in the hematolymphoid compartment and has specific roles in differentiation and function of various immune cells...
  48. doi Netrin-1-induced activation of Notch signaling mediates glioblastoma cell invasion
    Irene Ylivinkka
    Department of Pathology, The Haartman Institute, Translational Cancer Biology Research Program and Helsinki University Hospital, University of Helsinki, Finland
    J Cell Sci 126:2459-69. 2013
    ..purification and mass spectrometry protein identification we found that netrin-1 forms a complex with both Notch2 and Jagged1...
  49. ncbi G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently
    P M O'Connor
    Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 268:8298-308. 1993
    ..temporal regulation of cyclin A- and B1-dependent kinases in human lymphoma cells treated with nitrogen mustard (HN2) and pentoxifylline, to determine whether the activity of these complexes correlated with cell cycle arrest induced ..
  50. ncbi Differential inhibition of the DNA binding of transcription factors NF kappa B and OTF-1 by nitrogen mustard and quinacrine mustard: transcriptional implications
    S Fabbri
    Laboratory of Cancer Chemotherapy, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Carcinogenesis 14:1963-7. 1993
    Nitrogen mustard (HN2) and quinacrine mustard (QM) both inhibited the binding of NF kappa B to the GC-rich consensus sequence in the HIV long terminal repeat (LTR), as assessed by gel-shift assays...
  51. ncbi Overexpression of GSTA2 protects against cell cycle arrest and apoptosis induced by the DNA inter-strand crosslinking nitrogen mustard, mechlorethamine
    Jingping Xie
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 5310, USA
    J Cell Biochem 95:339-51. 2005
    ..were characterized in human hematopoietic cells occurring in response to the nitrogen mustard, mechlorethamine (HN2), but not in response to monofunctional analogs...
  52. ncbi Efficient protection of human bronchial epithelial cells against sulfur and nitrogen mustard cytotoxicity using drug combinations
    S Rappeneau
    Laboratoire de Cytophysiologie et Toxicologie Cellulaire, université Paris VII Denis Diderot, Tour 53 54, E3 case 7073, 2 place Jussieu, 75251 Paris Cedex 05, France
    Toxicol Sci 58:153-60. 2000
    ..study was to test the efficacy of several candidate molecules against sulfur mustard (SM) and nitrogen mustard (HN2) using a human bronchial-epithelial cell line (16HBE14o-)...
  53. ncbi Delta-notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation
    T A Mitsiadis
    Faculté d Odontologie, Universite de la Mediterranee, Marseille Cedex 20, 13916, France
    Dev Biol 204:420-31. 1998
    ..The expression pattern of Delta1 in ameloblasts and odontoblasts is complementary to Notch1, Notch2, and Notch3 expression in adjacent epithelial and mesenchymal cells...
  54. ncbi Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality
    Y Hamada
    National Institute for Basic Biology, Okazaki, Aichi 444 8585, Japan
    Development 126:3415-24. 1999
    ..Using gene targeting procedures, we disrupted the mouse Notch2 gene by replacing all but one of the ankyrin repeat sequences in the cytoplasmic domain with the E...
  55. ncbi The role of notch signaling in the development of intrahepatic bile ducts
    Yuzo Kodama
    Department of Gastroenterology and Hepatology, Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Gastroenterology 127:1775-86. 2004
    ..The mechanism underlying the contribution of the Notch signaling pathway to IHBD formation, however, remains unknown. Here we investigated the role of Notch signaling in IHBD development...
  56. ncbi Chemosensitivity of primary human fibroblasts with defective unhooking of DNA interstrand cross-links
    Peter H Clingen
    Cancer Research UK Drug DNA Interactions Research Group, Department of Oncology, Royal Free and University College Medical School, 91 Riding House Street, London, W1W 7BS, UK
    Exp Cell Res 313:753-60. 2007
    ..In clonogenic survival assays, primary fibroblasts from XP-F patients were moderately sensitive to both UVC and HN2 compared to normal cells (2- to 3-fold and 3- to 5-fold, respectively)...
  57. ncbi Ebselen protects brain, skin, lung and blood cells from mechlorethamine toxicity
    Diane Hardej
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, NY 11439, USA
    Toxicol Ind Health 23:209-21. 2007
    ..The purpose of this study was to investigate the in vitro toxicity of the nitrogen mustard mechlorethamine (HN2) in four cell models: CEM-SS human T cells, A431 human skin epithelial cells, rat hippocampal astrocytes and rat ..
  58. ncbi Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions
    Yuji Seta
    Department of Cellular and Structural Biology and the Rocky Mountain Taste and Smell Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Comp Neurol 464:49-61. 2003
    ..All of the genes examined (except Notch2) are also expressed in subsets of cells within circumvallate taste buds in adult mice, although Notch1 is ..
  59. pmc Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard
    B Poon
    Department of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Virol 71:3961-71. 1997
    ..We previously reported that Vpr mimicked some of the effects of a DNA alkylating agent known as nitrogen mustard (HN2)...
  60. ncbi Characterization and developmental expression of the amphioxus homolog of Notch (AmphiNotch): evolutionary conservation of multiple expression domains in amphioxus and vertebrates
    L Z Holland
    Marine Biology Research Division, University of California at San Diego, La Jolla, California 92093 0202, USA
    Dev Biol 232:493-507. 2001
    ..AmphiNotch, like Drosophila Notch and vertebrate Notch1 and Notch2, has 36 EGF repeats, 3 Notch/lin-12 repeats, a transmembrane region, and 6 ankyrin repeats...
  61. ncbi PSO4: a novel gene involved in error-prone repair in Saccharomyces cerevisiae
    J A Henriques
    Universidade Federal do Rio Grande do Sul, Departamento de Fisiologia, Farmacologia e Bioquímica, RS, Brasil
    Mutat Res 218:111-24. 1989
    ..Regarding inactivation, the pso4-1 mutant is also sensitive to mono- (HN1) or bi-functional (HN2) nitrogen mustards, it is slightly sensitive to 254 nm UV radiation (UV), and shows nearly normal sensitivity to 3-..
  62. pmc Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice
    Erin E Sparks
    Department of Cell and Developmental Biology and Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, TN, USA
    Hepatology 51:1391-400. 2010
    ..Although Notch2 has a dominant role in IHBD formation, there is also a redundant role for other Notch receptors in determining the ..
  63. doi Cloning, characterization and expression of the extracellular lipase gene from Aureobasidium pullulans HN2-3 isolated from sea saltern
    Zhiqiang Liu
    UNESCO Chinese Center of Marine Biotechnology, Ocean University of China, Yushan Road, No 5, Qingdao, China
    Antonie Van Leeuwenhoek 94:245-55. 2008
    The extracellular lipase structural gene was isolated from cDNA of Aureobasidium pullulans HN2-3 by using SMART(TM) RACE cDNA amplification kit. The gene had an open reading frame of 1245 bp long encoding a lipase...
  64. pmc DNA polymerase II (polB) is involved in a new DNA repair pathway for DNA interstrand cross-links in Escherichia coli
    M Berardini
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Bacteriol 181:2878-82. 1999
    ..A plasmid with a single nitrogen mustard (HN2) interstrand cross-link (inter-HN2-pTZSV28) was constructed and transformed into Escherichia coli, and its ..
  65. ncbi [Phyllanthus urinaria extract promotes N-cadherin expression in nitrogen mustard-disrupted testicular tissues in vivo]
    De ying Zhang
    Department of Urology, Children s Hospital, Chongqing Medical University, Chongqing 400014, China
    Zhonghua Nan Ke Xue 14:396-400. 2008
    To explore the protective effect of the Phyllanthus Urinaria (PU) extract on the N-cadherin expression in the testicular tissues disrupted by nitrogen mustard (HN2) in vivo.
  66. doi Reduction of vesicant toxicity by butylated hydroxyanisole in A-431 skin cells
    Maria A Pino
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, New York, USA
    Cutan Ocul Toxicol 27:161-72. 2008
    Mechlorethamine (HN2) and 2-chloroethylethyl sulfide (CEES) are mustard vesicants. Butylated hydroxyanisole (BHA) is a phenolic antioxidant...
  67. pmc DNA repair modulates the vulnerability of the developing brain to alkylating agents
    G E Kisby
    Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, OR 97239, United States
    DNA Repair (Amst) 8:400-12. 2009
    ..sulfate (DMS) and the mono- and bifunctional alkylating agents chloroethylamine (CEA) and nitrogen mustard (HN2), in granule cell neurons derived from the cerebellum of neonatal wild type mice and three transgenic DNA repair ..
  68. ncbi Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the notch-2 pathway
    H Nakayama
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Dev Genet 21:21-30. 1997
    ..These data suggest that Notch signaling through activation of HES transcriptional repressors may play a role in murine placental development...
  69. ncbi Protection from cytotoxic effects induced by the nitrogen mustard mechlorethamine on human bronchial epithelial cells in vitro
    S Rappeneau
    Laboratoire de Cytophysiologie et Toxicologie Cellulaire, université Paris VII Denis Diderot, France
    Toxicol Sci 54:212-21. 2000
    The present study was undertaken to find potent molecules against the toxicity of nitrogen mustard mechlorethamine (HN2) on respiratory epithelial cells, using a human bronchial epithelial cell line (16HBE14o-) as an in vitro model...
  70. ncbi A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency
    Brent McCright
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Development 129:1075-82. 2002
    ..1999) HUM: Mol. Genet. 8, 723-730). Here we report that mice doubly heterozygous for the Jag1 null allele and a Notch2 hypomorphic allele exhibit developmental abnormalities characteristic of Alagille syndrome...
  71. pmc Glycogene expression in conjunctiva of patients with dry eye: downregulation of Notch signaling
    Flavio Mantelli
    Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 50:2666-72. 2009
    ..This study aimed to identify the repertoire of genes (glycogenes) involved in biosynthesis of glycoconjugates in conjunctiva of normal subjects and patients with dry eye...
  72. ncbi Mitochondrial inside-out signalling during alkylating agent-induced anoikis
    Matthieu Sourdeval
    Laboratoire de Genetique et Biologie Cellulaire, UMR 8159, Universite de Versailles St Quentin en Yvelines, Batiment Buffon, 45 Avenue des Etats Unis, 78035 Versailles Cedex, France
    Front Biosci (Landmark Ed) 14:1917-31. 2009
    Exposure of epithelial respiratory cells to the alkylating agent, mechlorethamine (HN2), induces anoikis initiated by mitochondrial depolarization and caspase-2 activation...
  73. doi How the NOTCH pathway contributes to the ability of osteosarcoma cells to metastasize
    Dennis P M Hughes
    Children s Cancer Hospital, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
    Cancer Treat Res 152:479-96. 2009
    ..Better understanding of Notch's role and its regulation will be essential in planning therapies with other agents, especially the use of valproic acid and other HDAC inhibitors...
  74. ncbi Elucidation of correspondence between swine chromosome 4 and human chromosome 1 by assigning 27 genes to the ImpRH map, and development of microsatellites in the proximity of 14 genes
    H Hiraiwa
    New Energy and Industrial Technology Development Organization, Toshima, Tokyo, Japan
    Cytogenet Genome Res 101:84-9. 2003
    ..27 genes, PTGFR, GBP1, GBP2, GFI1, GCLM, ABCD3, EXTL2, KCNA3, ADORA3, KCND3, WNT2B, NRAS, SYCP1, PTGFRN, IGSF2, NOTCH2, S100A10, SHC1, SSR2, LMNA, CCT3, CD5L, PEA15, FCER1G, EAT2, DDR2, and LAMB3, located in the HSA1 region ..
  75. doi Alkaline protease gene cloning from the marine yeast Aureobasidium pullulans HN2-3 and the protease surface display on Yarrowia lipolytica for bioactive peptide production
    Xiumei Ni
    UNESCO Chinese Center of Marine Biotechnology, Ocean University of China, Yushan Road, No 5, Qingdao, China
    Mar Biotechnol (NY) 11:81-9. 2009
    ..ALP2 gene) were amplified from complementary DNA (cDNA) and genomic DNA of the marine yeast Aureobasidium pullulans HN2-3, respectively...
  76. doi Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice
    Jan S Tchorz
    Department of Biomedicine, Institute of Physiology, University of Basel, Switzerland
    Hepatology 50:871-9. 2009
    ..Alagille syndrome patients, who suffer from bile duct paucity, carry Jagged1 and Notch2 mutations, indicating that Notch2 signaling is important for IHBD development...
  77. pmc A large-scale screen for mutagen-sensitive loci in Drosophila
    Anne Laurencon
    Section of Molecular and Cellular Biology, University of California, Davis, California 95616, USA
    Genetics 167:217-31. 2004
    ..Zuker) for hypersensitivity to methyl methanesulfonate (MMS) and nitrogen mustard (HN2)...
  78. ncbi Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration
    Jan Nygaard Jensen
    Barbara Davis Center for Childhood Diabetes, U Colorado, HSC, 4200 E 9th Avenue, B140, Denver, Colorado 80262 USA
    Gastroenterology 128:728-41. 2005
    ..To define cell differentiation changes associated with pancreatic regeneration in adult mice, we compared regeneration following caerulein-induced pancreatitis to that of normal pancreatic development...
  79. ncbi Aquatic toxicity of nitrogen mustard to Ceriodaphina dubia, Daphnia magna, and Pimephales promelas
    Cheng Hang Lan
    Department of Industrial Safety and Hygiene, Chung Hwa College of Medical Technology, 89 Wen hwai 1st St Jen te hsiang, Tainan, Hsien, Taiwan
    Ecotoxicol Environ Saf 61:273-9. 2005
    ..In this study, the 48-h LC50 values of nitrogen mustard (HN2) are reported for two aquatic invertebrate species (Daphnia magna and Ceriodaphnia dubia) and for one fish species (..
  80. ncbi Alkalibacillus silvisoli sp. nov., an alkaliphilic moderate halophile isolated from non-saline forest soil in Japan
    Ron Usami
    Department of Applied Chemistry, Faculty of Engineering, and Bio Nano Electronics Research Centre, Toyo University, 2100 Kujirai, Kawagoe, Saitama 350 8585, Japan
    Int J Syst Evol Microbiol 57:770-4. 2007
    Two alkaliphilic, moderately halophilic bacteria, designated BM2(T) and HN2, were isolated from non-saline forest soil in Japan. The cells of strain BM2(T) were motile, aerobic, rod-shaped and Gram-positive...
  81. doi Ectopic germinal centers are rare in Sjogren's syndrome salivary glands and do not exclude autoreactive B cells
    Laetitia Le Pottier
    Equipe d Accueil 2216 and Institut Fédératif de Recherche 418, Science et Ingénierie en Biologie Santé, Universite de Brest, Brest, and Universite europeenne de Bretagne, Brest, France
    J Immunol 182:3540-7. 2009
    ..Interestingly, both types of B cell aggregates include autoreactive B cells...
  82. pmc Microarray analysis of oxidative stress regulated genes in mesencephalic dopaminergic neuronal cells: relevance to oxidative damage in Parkinson's disease
    Vellareddy Anantharam
    Parkinson s Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011 1250, USA
    Neurochem Int 50:834-47. 2007
    ..mesencephalon-derived N27 cell line, the GABAergic striatum-derived M213-20 cell line, and the hippocampal HN2-5 cell line. N27 cells were more sensitive to H2O2-induced cell death than M213-20 and HN2-5 cells...
  83. pmc Jagged1 functions downstream of Twist1 in the specification of the coronal suture and the formation of a boundary between osteogenic and non-osteogenic cells
    Hai Yun Yen
    Department of Biochemistry and Molecular Biology, Norris Cancer Hospital, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089 9176, USA
    Dev Biol 347:258-70. 2010
    ..These changes, surprisingly, are associated with increased expression of Notch2 and the Notch effector, Hes1, in the sutural mesenchyme...
  84. doi A genetic strategy involving a glycosyltransferase promoter and a lipid translocating enzyme to eliminate cancer cells
    Kelly Levano
    CUNY Doctoral Program in Biochemistry, City University of New York at the College of Staten Island, Staten Island, NY 10314, USA
    Glycoconj J 26:739-48. 2009
    ..that the P-type ATPase Atp8a1 is the plasma membrane APLT of the tumorigenic N18 cells, but not the non-tumorigenic HN2 (hippocampal neuron x N18) cells...
  85. doi Notch ligands expressed by follicular dendritic cells protect germinal center B cells from apoptosis
    Sun Ok Yoon
    Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    J Immunol 183:352-8. 2009
    ..dendritic cells (FDC) but not by B cells in the GC, while GC-B cells express the Notch receptors, Notch1 and Notch2. The blockade of Notch signaling pathways using a gamma-secretase inhibitor, DAPT (N-[N-(3,5-difluorophenacetyl-l-..
  86. ncbi The PSO4 gene is responsible for an error-prone recombinational DNA repair pathway in Saccharomyces cerevisiae
    H H de Andrade
    Universidade Federal do Rio Grande do Sul, Departamento de Genetica, Porto Alegre, Brazil
    Mol Gen Genet 217:419-26. 1989
    ..induced by photoaddition of mono- and bifunctional psoralen derivatives as well as by mono- (HN1) and bifunctional (HN2) nitrogen mustards or 254 nm UV radiation in both stationary and exponential phases of growth...
  87. ncbi Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth
    Tuija Mustonen
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Helsinki FIN 00014, Finland
    Dev Biol 248:281-93. 2002
    ..The Lunatic fringe expression domains overlapped only partly with the expression of Notch1 and Notch2, which were coexpressed with Hes1...
  88. ncbi Molecular characterization of two distinct begomoviruses from Papaya in China
    Xiangyang Wang
    Institute of Biotechnology, Zhejiang University, Hangzhou 310029, People s Republic of China
    Virus Genes 29:303-9. 2004
    ..showed that the DNA-A of G2 and GD2 were most closely related to that of Ageratum yellow vein China virus- [Hn2] and Ageratum yellow vein virus , respectively, with 83.4 and 75...
  89. pmc Isolation, sequencing, and functional analysis of the TATA-less murine ATPase II promoter and structural analysis of the ATPase II gene
    Tomasz Sobocki
    Department of Chemistry and the CSI IBR Center for Developmental Neuroscience, City University of New York at the College of Staten Island, Staten Island, NY 10314, USA
    Biochim Biophys Acta 1769:61-75. 2007
    ..In the neuronal HN2, N18, SN48 cells and the NIH3T3 fibroblast cells, but not in the B16F10 melanoma cells, the core promoter (-318/+..
  90. pmc Notch activation is associated with tetraploidy and enhanced chromosomal instability in meningiomas
    Gilson S Baia
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
    Neoplasia 10:604-12. 2008
    ..Activated Notch1 and Notch2 receptors induced endogenous HES1 expression and were associated with tetraploidy in meningiomas...
  91. ncbi Properties of alkaline protease genetically engineered on cell surface of the yeast Yarrowia lipolytica
    Xiumei Ni
    UNESCO Chinese Center of Marine Biotechnology, Ocean University of China, Yushan Road, No 5, Qingdao, China
    Indian J Biochem Biophys 46:294-8. 2009
    ALP2 gene encoding alkaline protcase cloned from Aureobasidium pullulans HN2-3 was ligated into the surface display plasmid and expressed in the cells of the yeast Yarrowia lipolytica...
  92. doi Genetic diversity of Potato virus Y infecting tobacco crops in China
    Y P Tian
    Department of Plant Pathology, Shandong Agricultural University, Shandong, People s Republic of China
    Phytopathology 101:377-87. 2011
    ..helper component proteinase (HC-pro) and, in this respect, were similar to the PVY(N-Wi), PVY(N:O), and PVY-HN2 isolates characterized from potato in Europe, the United States, and China, respectively; two isolates contained a ..
  93. doi Quantitative assessment of neurite outgrowth in human embryonic stem cell-derived hN2 cells using automated high-content image analysis
    Joshua A Harrill
    Systems Biology Branch, Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Neurotoxicology 31:277-90. 2010
    ..The present study characterizes the molecular phenotype of hN2 human embryonic stem cell (hESC)-derived neural cells and uses automated high-content image analysis to measure ..
  94. ncbi Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation
    B McCright
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Development 128:491-502. 2001
    ..To assess the in vivo role of the Notch2 gene, we constructed a targeted mutation, Notch2(del1)...
  95. pmc Activated Notch2 potentiates CD8 lineage maturation and promotes the selective development of B1 B cells
    Colleen M Witt
    Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 3300, USA
    Mol Cell Biol 23:8637-50. 2003
    Although studies have shown that the Notch2 family member is critical for embryonic development, little is known concerning its role in hematopoiesis...
  96. doi Expression and clinical significance of Notch receptors in human renal cell carcinoma
    Shiren Sun
    State Key Laboratory of Cancer Biology, Xijing Hospital, The Fourth Military Medical University, Xi an, Shaanxi, China
    Pathology 41:335-41. 2009
    ..Therefore, in this study, we examined the patterns of expression and clinical significance of Notch receptors in RCC...
  97. doi Molecular characterization and detection of recombinant isolates of potato virus Y from China
    Xinxi Hu
    Hunan Provincial Engineering Research Center for Potatoes, College of Horticulture and Landscape, Hunan Agricultural University, Changsha, Hunan 410128, China
    Arch Virol 154:1303-12. 2009
    ..The complete genome of a representative isolate, PVY-HN2, from the second type was subsequently sequenced...
  98. ncbi Ab initio study of alkylation of guanine-cytosine base pair by sulfur and nitrogen mustards
    Dan Vasilescu
    UNSA, ParcValrose 06108 Nice cedex 2, France
    J Biomol Struct Dyn 27:465-76. 2010
    Quantum modeling of the N7(G) alkylation of guanine-cytosine (G-C) base pair by sulfur (HD) and nitrogen mustard (HN2) was performed by using the Density Functional Theory (DFT) BPW91/6-31G++DP procedure...
  99. doi Liquiritigenin attenuates the learning and memory deficits in an amyloid protein precursor transgenic mouse model and the underlying mechanisms
    Rui Ting Liu
    Key Laboratory of Particle and Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing, China
    Eur J Pharmacol 669:76-83. 2011
    ..These findings provide evidence for beneficial activity of liquiritigenin in a mouse model of Alzheimer's disease and support the continued investigation of Notch signaling pathway as a target for treatment of Alzheimer's disease...
  100. pmc Notch signaling mediates TNF-α-induced IL-6 production in cultured fibroblast-like synoviocytes from rheumatoid arthritis
    Zhijun Jiao
    Key Laboratory of Medical Immunology and Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China
    Clin Dev Immunol 2012:350209. 2012
    ..Our data confirm the functional involvement of Notch pathway in the pathophysiology of RA FLSs which may provide a new target for RA therapy...
  101. doi c-Jun N-terminal kinase has a pivotal role in the maintenance of self-renewal and tumorigenicity in glioma stem-like cells
    C H Yoon
    Department of Chemistry, Research Institute for Natural Sciences, Hanyang University, Seoul, Korea
    Oncogene 31:4655-66. 2012
    ....

Research Grants45

  1. The role of ADAM10 in B cell development and humoral immunity
    NATALIA SOL CHAIMOWITZ; Fiscal Year: 2013
    ..Subsequent studies determined that ADAM10 is required for the proteolytic activation of Notch2 signaling...
  2. Molecular mechanisms of Bile Duct Proliferation in Mice with Glycosylation Defect
    MATTHEW JOSEPH RYAN; Fiscal Year: 2012
    ..Alagille syndrome (ALGS) is an autosomal dominant multi-system disorder caused by mutations in either the JAG1 or NOTCH2 genes and characterized by a paucity of bile ducts in the liver with resultant cholestasis...
  3. Molecular Mechanisms Underlying the Distinct Functions of Notch1 and Notch2
    Matthew R Hass; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Project summary: Notchl and Notch2 are redundantly required during mammalian development and stem cell differentiation in different tissues, yet each protein has acquired the ability to perform unique ..
  4. Ernesto Canalis; Fiscal Year: 2016
    ..models expressing Notch in the osteocyte environment, and models of conditional inactivation of Notch1 and Notch2 in osteocytes...
  5. Nadean L Brown; Fiscal Year: 2016
    ..Interestingly, Notch1-/-, Notch2-/- and Jagged1 mutant mice each have prenatal eye phenotypes, but little is known about the roles of these genes ..
  6. Robert S Haltiwanger; Fiscal Year: 2016
    ..Here we will refine and test our model by examining whether glycosylation of the same regions also affect Notch2, which is essential for development but plays distinct non-redundant roles with Notch1...
  7. Ulf Klein; Fiscal Year: 2014
    ..that IRF4-deficiency causes aberrant migration and homing of mature B cells, possibly due to hyperactivation of NOTCH2 signaling...
  8. MECHANISM OF CYCLOPHOSPHAMIDE TOXICITY
    JAMES KEHRER; Fiscal Year: 1999
    ..6) to determine if and how nor-HN2 can enhance the bladder toxicity induced by these conjugates...
  9. INTERACTION OF AMINOTHIOLS AND ALKYLATING AGENTS
    Frederick Valeriote; Fiscal Year: 1990
    ..project is to define the cellular and molecular basis for the potentiation of the cytotoxicity of nitrogen mustard (HN2) to leukemia cells observed following aminothiol pretreatment...
  10. Timothy W King; Fiscal Year: 2016
    ..Our working hypothesis is that activating notch will increase the rate of closure and improve the barrier function of the wounded skin. ..
  11. Regulation of ATPase II and Clearance of Cancer Cells
    Probal Banerjee; Fiscal Year: 2004
    ..of ATPase II causes appearance of mixed, voltage-gated calcium channels in a hippocampal neuron-derived cell line, HN2, which normally does not display any calcium current...
  12. Genetic Modifiers of Liver Disease Severity in Alagille Syndrome
    Nancy Bettina Spinner; Fiscal Year: 2013
    ..Mutations in Jagged1 (JAG1) are found in 95% of patients and mutations in Notch2 in less than 1%. AGS causes significant morbidity associated with liver, cardiac, renal and vascular malformations...
  13. Cux-1 and cell cycle regulation in kidney development
    Gregory Vanden Heuvel; Fiscal Year: 2009
    ..2. Evaluate the interaction between TLE proteins and Cux-1. 3. Define the relationship between Cux-1 and Notch2 in kidney development in vivo. 4...
  14. Sonia Caprio; Fiscal Year: 2014
    ..aims are: Aim 1: A) To examine the relationships between a panel of 16 gene variants (TCF7L2, PPARG, FTO, KCNJ11, NOTCH2, WFS1, CDKAL1, IGF2BP2, SLC30A8, JAZF1, HHEX, CDC123/CAMK1D, WFS1, TSPAN8/LGR5, THADA, ADAMTS9) and measures of ..
  15. Gian Paolo Dotto; Fiscal Year: 2016
    ..gene, the key effector of Notch signaling, results in cell senescence and assess to what extent the Notch1 and/or Notch2 genes are involved...
  16. Role of Notch and Kidney Development
    Raphael Kopan; Fiscal Year: 2012
    ..The first essential function of Notch is during nephron segmentation. Notch2 signals block distal identities and promote proximal tubule (PT) and podocyte (POD) identities either cell ..
  17. Robert E Maxson; Fiscal Year: 2014
    ..Moreover, conditional inactivation of Jagged1 in these cells results in synostosis, and to an upregulation of Notch2 and Hes1 in the suture...
  18. Molecular Biology of Cardiac Valvuloseptal Morphogenesis
    DAVID GEENAN; Fiscal Year: 2006
    ..signaling pathway in Hey2 mutant animals, as well as the expression of Hey2 in animals lacking Jag1, Notch1, or Notch2. Furthermore we will test for genetic interactions between the Hey2 and Jag, Notch1, or Notch2 mutant alleles...
  19. Notch function in myocardial development and homeostasis
    Mark Mercola; Fiscal Year: 2010
    ..Notch transcriptional mediator CSL/RBPJ/Su(H) revealed defects that, combined with expression data, indicate that Notch2 activity is essential for ventricular myocardial proliferation and morphogenesis...
  20. Fanxin Long; Fiscal Year: 2016
    ..Hyperactivation of NOTCH2 has recently been discover to cause Hajdu-Cheney syndrome (HCS) characterized by childhood osteoporosis, ..
  21. Cell Fate By Notch Ligands
    IRWIN A BERNSTEIN; Fiscal Year: 2011
    ..Since effects of ligands depend upon the particular receptor interactions, we will use Notchl and Notch2 conditional knockout mouse models and RNA interference to determine how interactions of Deltal with different ..
  22. The Role of Notch Signaling in Tcell Function
    Barbara A Osborne; Fiscal Year: 2010
    ..At least three of these proteins, Notch1, Notch2 and Notch3, are expressed at various times during lymphoid development...
  23. Molecular Analysis of Alagille Syndrome
    NANCY SPINNER; Fiscal Year: 2006
    ..What factors modify disease expressivity? Is disease gene variability caused by polymorphisms in JAG1 itself? in Notch2? or in other members of the Notch signaling pathway? 5) Can genetic analysis of mouse mutants reveal genes that ..
  24. A Model for Olfactory Epithelial Neurodegeneration in Alzheimer's Disease
    David M Lin; Fiscal Year: 2010
    ..We demonstrate that the Notch2 receptor plays a key role in maintaining normal glial function in the olfactory epithelium...
  25. Correlative Genetic Markers in Childhood Hepatoblastoma
    Gail Tomlinson; Fiscal Year: 2009
    ..array comparative genomic hybridization (oaCGH) that the translocation breakpoint lies in the vicinity of NOTCH2, a gene involved in liver development and specifically in hepatoblast differentiation...
  26. NOTCH2 AND B LYMPHOCYTE DEVELOPMENT
    Christian Kuhr; Fiscal Year: 2003
    ..The specific aims are: (1) To direct expression of a constitutively- activated or dominant-negative Notch2 in B lymphocytes during lymphopoiesis in mice, (2) To define the phenotypic alterations cause by manipulations of ..
  27. INVESTIGATING A ROLE FOR NOTCH SIGNALING IN ANGIOGENESIS
    GERALDINE WEINMASTER; Fiscal Year: 2001
    ..with a role for Notch signaling during vascularization of the CAM, we have detected the expression of Notch1, Notch2, Jagged1 and Delta1 during development of this membrane and we are currently determining the CAM cell types that ..
  28. Pathogenesis of Notch Leukemia
    Jon Aster; Fiscal Year: 2007
    ..cell lines, suggesting a role for Notch1 in leukemia cell growth and survival; and 3), constitutively active Notch2 and Notch3 also cause T-ALL in our murine model, whereas Notch4 does not...
  29. Conf. on Research Education & Training in Otolaryngology
    Jennifer Grandis; Fiscal Year: 2005
    ..abstract_text> ..
  30. P53 Based Vaccine for Small Cell Lung Cancer
    Dmitry Gabrilovich; Fiscal Year: 2007
    ..Specific Aim 2. Determine the immune modifying effect of immunization and chemotherapy on p53-specific immunity. [unreadable] [unreadable] [unreadable]..
  31. MEMBRANE IMMUNOGLOBULIN ASSEMBLY AND FUNCTION
    Shiv Pillai; Fiscal Year: 2002
    ..Since the majority of human lymphomas develop form activated B-cells, these signaling mechanisms are likely to be of direct relevance for a significant proportion of human cancers. ..
  32. Molecular identification of a sialyl 9-O-acetyl transferase
    Shiv Pillai; Fiscal Year: 2008
    ..The gene that codes for an enzyme that controls the strength of the immune response will be studied. This gene may be an important target for the treatment of lupus and other related diseases. [unreadable] [unreadable] [unreadable]..
  33. Marginal zone B lymphocytes and blood borne pathogens
    Shiv Pillai; Fiscal Year: 2004
    ..Finally we will attempt to determine whether antigen-specific MZ B cells, as opposed to follicuar B cells, can readily capture and present blood borne antigens, and thus activate na'fve T cells. ..
  34. SIGNALING MOLECULES IN BILE DUCT DEVELOPMENT
    Kathleen Loomes; Fiscal Year: 2004
    ..abstract_text> ..
  35. Imaging of EGFR Targeting in Head and Neck Cancer
    Jennifer Grandis; Fiscal Year: 2004
    ..abstract_text> ..
  36. THE ROLE OF NOTCH SIGNALING IN BILE DUCT DEVELOPMENT
    Kathleen Loomes; Fiscal Year: 2004
    ..A compound heterozygous mouse for mutations in Jag1, encoding a ligand in the Notch pathway, and Notch2, encoding one of the Notch cell surface receptors, exhibits many features seen in patients affected with Alagille ..
  37. Studies on human peripheral B lymphocytes
    Shiv Pillai; Fiscal Year: 2005
    ....
  38. The role of PKK in NFkappa B activation
    Shiv Pillai; Fiscal Year: 2007
    ..PKK represents a novel enzyme that may be critical in pathways that are important in cancer, inflammation, cell survival, and differentiation. ..
  39. ATRA effect on myeloid cell differentiation in cancer
    Dmitry Gabrilovich; Fiscal Year: 2005
    ..In the proposed clinical trial we will test the hypothesis that ATRA eliminates immature myeloid cells and improves differentiation of DC in cancer patients. If proven this approach can be used to enhance the effects of cancer vaccines. ..
  40. Phenotype-Genotype Interactions and Type 2 Diabetes
    James Meigs; Fiscal Year: 2005
    ..Results will provide a foundation for future laboratory efforts and will increase understanding of phenotype-genotype interactions in diabetes pathogenesis. ..
  41. Conference on immune suppression in cancer
    Dmitry Gabrilovich; Fiscal Year: 2007
    ..tumor escape of immune system control; [unreadable] Review and discuss how our knowledge of new mechanisms of tumor associated immune suppression can be translated into new therapeutics [unreadable] [unreadable] [unreadable] [unreadable]..
  42. Stat3 as a Therapeutic Target in Head and Neck Cancer
    Jennifer Grandis; Fiscal Year: 2008
    ..abstract_text> ..
  43. Somatomedin: Autologous Regulator of Bone Formation
    Ernesto Canalis; Fiscal Year: 2008
    ..These investigations should clarify the role of CHOP in bone cell differentiation and function. [unreadable] [unreadable]..
  44. The Role of the Notch Pathway in Bile Duct Development
    KATHLEEN MARY LOOMES; Fiscal Year: 2010
    ..We will assess their response to defined stimuli, and rescue the phenotype by transfecting with activated Notch ..
  45. Transformation of Epithelial Cell by E6 Oncogene
    Lizi Wu; Fiscal Year: 2007
    ..The proposed research will advance our understanding of the molecular mechanisms of transformation of cervical cancers, as well as provide insight into the novel MAML family and the Notch signaling pathway. [unreadable] [unreadable]..