Gene Symbol: Notch1
Description: notch 1
Alias: AOS5, AOVD1, TAN1, hN1, neurogenic locus notch homolog protein 1, Notch homolog 1, translocation-associated, translocation-associated notch protein TAN-1
Species: human
Products:     Notch1

Top Publications

  1. Nigam V, Srivastava D. Notch1 represses osteogenic pathways in aortic valve cells. J Mol Cell Cardiol. 2009;47:828-34 pubmed publisher
    ..We reported two families in which heterozygous mutations in NOTCH1 caused bicuspid aortic valve and severe aortic valve calcification...
  2. Agrawal N, Frederick M, Pickering C, Bettegowda C, Chang K, Li R, et al. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science. 2011;333:1154-7 pubmed publisher
    ..addition to previously described mutations in TP53, CDKN2A, PIK3CA, and HRAS, we identified mutations in FBXW7 and NOTCH1. Nearly 40% of the 28 mutations identified in NOTCH1 were predicted to truncate the gene product, suggesting that ..
  3. Pistollato F, Rampazzo E, Persano L, Abbadi S, Frasson C, Denaro L, et al. Interaction of hypoxia-inducible factor-1α and Notch signaling regulates medulloblastoma precursor proliferation and fate. Stem Cells. 2010;28:1918-29 pubmed publisher
    ..Here, we investigate whether hypoxia, through HIF-1α stabilization, modulates Notch1 signaling in primary MDB-derived cells...
  4. Wang N, Sanborn Z, Arnett K, Bayston L, Liao W, Proby C, et al. Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci U S A. 2011;108:17761-6 pubmed publisher
    ..We identified NOTCH1 or NOTCH2 mutations in ~75% of cutaneous SCCs and in a lesser fraction of lung SCCs, defining a spectrum for the ..
  5. McGowan P, Simedrea C, Ribot E, Foster P, Palmieri D, Steeg P, et al. Notch1 inhibition alters the CD44hi/CD24lo population and reduces the formation of brain metastases from breast cancer. Mol Cancer Res. 2011;9:834-44 pubmed publisher
    ..011, Kruskal-Wallis). Notch1 knockdown reduced the expression of CD44(hi)/CD24(lo) phenotype by about 20%...
  6. Abdel Aziz M, Khaled H, El Hindawi A, Roshdy N, Rashed L, Sabry D, et al. Effect of mesenchymal stem cells and a novel curcumin derivative on Notch1 signaling in hepatoma cell line. Biomed Res Int. 2013;2013:129629 pubmed publisher
    ..and a novel curcumin derivative (NCD) on HepG2 cells (hepatoma cell line) and to investigate their effect on Notch1 signaling pathway target genes...
  7. Lin X, Liu B, Yang X, Yue X, Diao L, Wang J, et al. Genetic deletion of Rnd3 results in aqueductal stenosis leading to hydrocephalus through up-regulation of Notch signaling. Proc Natl Acad Sci U S A. 2013;110:8236-41 pubmed publisher
    ..Inhibition of Notch activity rescued the hydrocephalus disorder in the mutant animals. ..
  8. Hassan K, Wang L, Korkaya H, Chen G, Maillard I, Beer D, et al. Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. Clin Cancer Res. 2013;19:1972-80 pubmed publisher
    ..Notch activity can identify lung cancer stem cell-like population and its inhibition may be an appropriate target for treating lung adenocarcinoma. ..
  9. Hristova N, Tagscherer K, Fassl A, Kopitz J, Roth W. Notch1-dependent regulation of p27 determines cell fate in colorectal cancer. Int J Oncol. 2013;43:1967-75 pubmed publisher
    ..Here, we demonstrate that in colorectal carcinoma cells the Notch1-dependent activation of cell cycle and proliferation is mediated by repression of the cyclin-dependent kinase ..

More Information

Publications212 found, 100 shown here

  1. Zhang L, Dong Y, Zhu N, Tsoi H, Zhao Z, Wu C, et al. microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer. Mol Cancer. 2014;13:124 pubmed publisher
    ..001) and invasiveness (P?<?0.001) through the inhibition of matrix metalloproteinases (MMP)7 and MMP9. Oncogene NOTCH1 was revealed to be a putative target of miR-139-5p, which was inversely correlated with miR-139-5p expression (r?=?..
  2. Bu P, Chen K, Chen J, Wang L, Walters J, Shin Y, et al. A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells. Cell Stem Cell. 2013;12:602-15 pubmed publisher
    ..Mechanistically, miR-34a sequesters Notch1 mRNA to generate a sharp threshold response where a bimodal Notch signal specifies the choice between self-renewal ..
  3. Arruga F, Gizdić B, Serra S, Vaisitti T, Ciardullo C, Coscia M, et al. Functional impact of NOTCH1 mutations in chronic lymphocytic leukemia. Leukemia. 2014;28:1060-70 pubmed publisher
    The purpose of this study was to compare the expression and function of NOTCH1 in chronic lymphocytic leukemia (CLL) patients harboring a wild-type (WT) or mutated NOTCH1 gene...
  4. Ma J, Tang X, Wong P, Jacobs B, Borden E, Bedogni B. Noncanonical activation of Notch1 protein by membrane type 1 matrix metalloproteinase (MT1-MMP) controls melanoma cell proliferation. J Biol Chem. 2014;289:8442-9 pubmed publisher
    b>Notch1 is an evolutionarily conserved signaling molecule required for stem cell maintenance that is inappropriately reactivated in several cancers...
  5. Sakamoto K, Fujii T, Kawachi H, Miki Y, Omura K, Morita K, et al. Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms. Lab Invest. 2012;92:688-702 pubmed publisher
    ..Here, we clarified basal-cell dominant expression of NOTCH1 in squamous epithelium...
  6. Zhou Q, Wang Y, Peng B, Liang L, Li J. The roles of Notch1 expression in the migration of intrahepatic cholangiocarcinoma. BMC Cancer. 2013;13:244 pubmed publisher
    ..In this study, we evaluated the expression and effects of Notch1 on cell migration in ICC.
  7. Zhou L, Zhang N, Song W, You N, Li Q, Sun W, et al. The significance of Notch1 compared with Notch3 in high metastasis and poor overall survival in hepatocellular carcinoma. PLoS ONE. 2013;8:e57382 pubmed publisher
    ..b>Notch1 and Notch3 may be involved in malignant transformation, although their roles remain unknown...
  8. García Peydró M, de Yebenes V, Toribio M. Sustained Notch1 signaling instructs the earliest human intrathymic precursors to adopt a gammadelta T-cell fate in fetal thymus organ culture. Blood. 2003;102:2444-51 pubmed
    b>Notch1 activity is essential for the specification of T-lineage fate in hematopoietic progenitors. Once the T-cell lineage is specified, T-cell precursors in the thymus must choose between alphabeta and gammadelta lineages...
  9. Moehlmann T, Winkler E, Xia X, Edbauer D, Murrell J, Capell A, et al. Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production. Proc Natl Acad Sci U S A. 2002;99:8025-30 pubmed
    ..Finally, we show that PS1 L166 mutants affect the generation of NICD and AICD in a similar manner, supporting the concept that S3 protease and S3-like gamma-secretase cleavages are mediated by identical proteolytic activities. ..
  10. Lee C, Simin K, Liu Q, Plescia J, Guha M, Khan A, et al. A functional Notch-survivin gene signature in basal breast cancer. Breast Cancer Res. 2008;10:R97 pubmed publisher
    ..Antagonists of Notch and survivin currently in the clinic may be tested as novel molecular therapy for these recurrence-prone patients. ..
  11. Yeh T, Wu C, Hsu K, Liao W, Yang M, Li A, et al. The activated Notch1 signal pathway is associated with gastric cancer progression through cyclooxygenase-2. Cancer Res. 2009;69:5039-48 pubmed publisher
    ..Herein, we sought to address whether Notch1 signal pathway is involved in the control of progression in gastric cancer...
  12. Eliasz S, Liang S, Chen Y, De Marco M, Machek O, Skucha S, et al. Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway. Oncogene. 2010;29:2488-98 pubmed publisher
    ..Our data provide a mechanistic explanation for Notch-1-mediated pro-survival function in hypoxic ACL tumor microenvironment. The results identify additional targets that may synergize with Notch-1 inhibition for ACL treatment. ..
  13. Siar C, Nakano K, Ng K, Tomida M, Nagatsuka H, Kawakami T. Squamous odontogenic tumor of the mandible: a case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1. Eur J Med Res. 2010;15:180-4 pubmed
    ..evaluation showed positive reactivity of varying intensity in the neoplastic epithelial cells for Notch1, Notch3, Notch4, and their ligands Jagged1 and Delta1. Expression patterns showed considerable overlap...
  14. Xu X, Zhao Y, Xu M, Dai Q, Meng W, Yang J, et al. Activation of Notch signal pathway is associated with a poorer prognosis in acute myeloid leukemia. Med Oncol. 2011;28 Suppl 1:S483-9 pubmed publisher
    ..To address this problem, we investigated the gene expression levels of Notch signal pathway members (Notch1, Jagged1 and Delta1) in bone marrow mononuclear cells by real-time quantitative PCR in a cohort of 100 patients ..
  15. Brabletz S, Bajdak K, Meidhof S, Burk U, Niedermann G, Firat E, et al. The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells. EMBO J. 2011;30:770-82 pubmed publisher
    ..These findings explain increased Notch signalling in some types of cancers, where mutations in Notch pathway genes are rare. Moreover, they indicate an additional way how ZEB1 exerts its tumour progressing functions. ..
  16. Moloney D, Panin V, Johnston S, Chen J, Shao L, Wilson R, et al. Fringe is a glycosyltransferase that modifies Notch. Nature. 2000;406:369-75 pubmed
  17. Jeffries S, Robbins D, Capobianco A. Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line. Mol Cell Biol. 2002;22:3927-41 pubmed
    ..3) translocation and constitutively express N(ic). Taken together, our data indicate that complex formation is likely required for neoplastic transformation by Notch(ic)...
  18. Wang L, Qin H, Chen B, Xin X, Li J, Han H. Overexpressed active Notch1 induces cell growth arrest of HeLa cervical carcinoma cells. Int J Gynecol Cancer. 2007;17:1283-92 pubmed
    ..We now show that Notch1 is detected in all cervical cancer, including advanced diseases...
  19. Arnett K, HASS M, McArthur D, Ilagan M, Aster J, Kopan R, et al. Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nat Struct Mol Biol. 2010;17:1312-7 pubmed publisher
    ..Here we report the X-ray structure of a dimeric human Notch1 transcription complex loaded on the paired site from the human HES1 promoter...
  20. Kishi N, Tang Z, Maeda Y, Hirai A, Mo R, Ito M, et al. Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis. Int J Dev Neurosci. 2001;19:21-35 pubmed
    ..genes were expressed in the central, peripheral nervous system and in the thymus, overlapping with those of mouse Notch1. In mammalian tissue culture cells, overexpression of any of the four mouse deltex homologs suppressed the ..
  21. Liu Z, Teng L, Bailey S, Frost A, Bland K, LoBuglio A, et al. Epithelial transformation by KLF4 requires Notch1 but not canonical Notch1 signaling. Cancer Biol Ther. 2009;8:1840-51 pubmed
    The transcription factors Notch1 and KLF4 specify epithelial cell fates and confer stem cell properties...
  22. Lim S, Park Y, Kim H, Quan X, Yoo J, Park Y, et al. Notch1 differentially regulates oncogenesis by wildtype p53 overexpression and p53 mutation in grade III hepatocellular carcinoma. Hepatology. 2011;53:1352-62 pubmed publisher
    ..Several other pathways have been implicated in HCC and, among these, the role of the Notch1/Snail pathway remains unclear...
  23. Marcet B, Chevalier B, Luxardi G, Coraux C, Zaragosi L, Cibois M, et al. Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway. Nat Cell Biol. 2011;13:693-9 pubmed publisher
    ..We established Notch1 and its ligand Delta-like 1(DLL1) as miR-449 bona fide targets...
  24. Izrailit J, Berman H, Datti A, Wrana J, Reedijk M. High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGF? pathways as fundamental Notch regulators in breast cancer. Proc Natl Acad Sci U S A. 2013;110:1714-9 pubmed publisher
    ..These data demonstrate a dominant role for TRB3 and MAPK-ERK/TGF? pathways as Notch regulators in breast cancer, establishing TRB3 as a potential therapeutic target. ..
  25. Zang S, Ji C, Qu X, Dong X, Ma D, Ye J, et al. A study on Notch signaling in human breast cancer. Neoplasma. 2007;54:304-10 pubmed
    ..Thus, targeting Notch signaling may be of therapeutic value in breast cancers. ..
  26. Logeat F, Bessia C, Brou C, LeBail O, Jarriault S, Seidah N, et al. The Notch1 receptor is cleaved constitutively by a furin-like convertase. Proc Natl Acad Sci U S A. 1998;95:8108-12 pubmed
    ..We report here that constitutive processing of murine Notch1 involves a furin-like convertase...
  27. Del Bianco C, Aster J, Blacklow S. Mutational and energetic studies of Notch 1 transcription complexes. J Mol Biol. 2008;376:131-40 pubmed
  28. Ma Y, Shi C, Zhang Y, Wang L, Liu H, Jia H, et al. The tyrosine kinase c-Src directly mediates growth factor-induced Notch-1 and Furin interaction and Notch-1 activation in pancreatic cancer cells. PLoS ONE. 2012;7:e33414 pubmed publisher
    ..Our findings have implications for the mechanism by which the Notch and growth factor receptor-c-Src signaling pathways regulate carcinogenesis and cancer cell growth. ..
  29. Ehebauer M, Chirgadze D, Hayward P, Martinez Arias A, Blundell T. High-resolution crystal structure of the human Notch 1 ankyrin domain. Biochem J. 2005;392:13-20 pubmed
    ..Based on the Notch 1 ANK structure and analysis of homologous Notch ANK sequences, we predict two possible binding sites on the domain: one on the concave surface of repeat 2 and the other below the hairpins of repeats 6-7. ..
  30. Larson Gedman A, Chen Q, Kugel Desmoulin S, Ge Y, LaFiura K, Haska C, et al. The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group. Leukemia. 2009;23:1417-25 pubmed publisher
    We explored the impact of mutations in the NOTCH1, FBW7 and PTEN genes on prognosis and downstream signaling in a well-defined cohort of 47 patients with pediatric T-cell acute lymphoblastic leukemia (T-ALL)...
  31. Veeraraghavalu K, Pett M, Kumar R, Nair P, Rangarajan A, Stanley M, et al. Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation. J Virol. 2004;78:8687-700 pubmed
    ..Intracellular Notch1 protein is detected in invasive cervical carcinomas (ICC), and truncated Notch1 alleles complement the function of ..
  32. Fabbri G, Rasi S, Rossi D, Trifonov V, Khiabanian H, Ma J, et al. Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation. J Exp Med. 2011;208:1389-401 pubmed publisher
    ..most of these genes were affected at low frequency in an expanded CLL screening cohort, mutational activation of NOTCH1, observed in 8...
  33. Ayyanan A, Civenni G, Ciarloni L, Morel C, Mueller N, Lefort K, et al. Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism. Proc Natl Acad Sci U S A. 2006;103:3799-804 pubmed
  34. Tamura K, Taniguchi Y, Minoguchi S, Sakai T, Tun T, Furukawa T, et al. Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H). Curr Biol. 1995;5:1416-23 pubmed
    ..Furthermore, in the mouse, the phenotypes of homozygous mutant Notch1 embryos are very similar to those of homozygous mutant RBP-J kappa embryos...
  35. Iwai A, Takegami T, Shiozaki T, Miyazaki T. Hepatitis C virus NS3 protein can activate the Notch-signaling pathway through binding to a transcription factor, SRCAP. PLoS ONE. 2011;6:e20718 pubmed publisher
    ..These results suggest that the HCV NS3 protein is involved in the activation of the Notch-signaling pathway through the targeting to both SRCAP and p400. ..
  36. Zhang X, Zheng G, Zou L, Liu H, Hou L, Zhou P, et al. Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells. Mol Cell Biochem. 2008;307:101-8 pubmed
    ..BT325, U251, SHG-44, and U87, mRNA encoding different types of Notch receptors were detected, but active form of Notch1 (NIC) was only detected in SHG-44 and U87 by Western blot...
  37. Lu Z, Liu H, Xu P, Hou G, Xue L. [Expression of Notch1 gene in esophageal squamous cell carcinoma cell line EC9706 and its effect on cell apoptosis]. Ai Zheng. 2007;26:1074-9 pubmed
    b>Notch1 signaling pathway is closely associated with carcinogenesis and plays a key role in cell growth, proliferation, differentiation, and apoptosis...
  38. Ma D, Dai J, Zhu X, Yan S, Zhao P, Zhang J, et al. Aberrant expression of Notch signaling molecules in patients with immune thrombocytopenic purpura. Ann Hematol. 2010;89:155-61 pubmed publisher
    ..b>Notch1 and Notch3 expression elevated, while Notch2 decreased statistically in ITP patients...
  39. Zuurbier L, Homminga I, Calvert V, te Winkel M, Buijs Gladdines J, Kooi C, et al. NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols. Leukemia. 2010;24:2014-22 pubmed publisher
    Aberrant activation of the NOTCH1 pathway by inactivating and activating mutations in NOTCH1 or FBXW7 is a frequent phenomenon in T-cell acute lymphoblastic leukemia (T-ALL)...
  40. Obata Y, Takahashi D, Ebisawa M, Kakiguchi K, Yonemura S, Jinnohara T, et al. Epithelial cell-intrinsic Notch signaling plays an essential role in the maintenance of gut immune homeostasis. J Immunol. 2012;188:2427-36 pubmed publisher
    ..Thus, epithelial cell-intrinsic Notch signaling ensures integrity and homeostasis of IEC, and this mechanism is required for containment of intestinal inflammation. ..
  41. Reschly E, Spaulding C, Vilimas T, Graham W, Brumbaugh R, Aifantis I, et al. Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms. Blood. 2006;107:4115-21 pubmed
    Loss of E2A transcription factor activity or activation of the intracellular form of Notch1 (ICN) leads to the development of leukemia or lymphoma in humans or mice, respectively...
  42. Fox V, Gokhale P, Walsh J, Matin M, Jones M, Andrews P. Cell-cell signaling through NOTCH regulates human embryonic stem cell proliferation. Stem Cells. 2008;26:715-23 pubmed
    ..Cleavage of both NOTCH1 and NOTCH2 to yield the intracellular domain responsible for the canonical signaling pathway of NOTCH was detected ..
  43. Tzoneva G, Ferrando A. Recent advances on NOTCH signaling in T-ALL. Curr Top Microbiol Immunol. 2012;360:163-82 pubmed publisher
    b>NOTCH1 receptor signaling plays a central role in T-cell lineage specification and in supporting the growth and proliferation of immature T-cell progenitors in the thymus during lymphoid development...
  44. Park M, Taki T, Oda M, Watanabe T, Yumura Yagi K, Kobayashi R, et al. FBXW7 and NOTCH1 mutations in childhood T cell acute lymphoblastic leukaemia and T cell non-Hodgkin lymphoma. Br J Haematol. 2009;145:198-206 pubmed publisher
    Mutation analysis of FBXW7 and NOTCH1 genes was performed in 55 T cell acute lymphoblastic leukaemia (T-ALL) and 14 T cell non-Hodgkin lymphoma (T-NHL) patients who were treated on the Japan Association of Childhood Leukaemia Study (JACLS)..
  45. Shen H, McElhinny A, Cao Y, Gao P, Liu J, Bronson R, et al. The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis. Genes Dev. 2006;20:675-88 pubmed
    ..Mechanistically, MAML1 appears to mediate cross-talk between Notch and MEF2 to influence myogenic differentiation. ..
  46. Hodkinson P, Elliott P, Lad Y, McHugh B, Mackinnon A, Haslett C, et al. Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras. J Biol Chem. 2007;282:28991-9001 pubmed
    ..This new CSL-independent Notch/R-Ras pathway provides a molecular mechanism to explain Notch, integrin, and Ras cross-talk during the development of multicellular organisms. ..
  47. Leong K, Niessen K, Kulic I, Raouf A, Eaves C, Pollet I, et al. Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. J Exp Med. 2007;204:2935-48 pubmed
    Aberrant expression of Jagged1 and Notch1 are associated with poor outcome in breast cancer. However, the reason that Jagged1 and/or Notch overexpression portends a poor prognosis is unknown...
  48. Kaether C, Schmitt S, Willem M, Haass C. Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface. Traffic. 2006;7:408-15 pubmed
    ..Similar results were obtained for another gamma-secretase substrate, NotchDeltaE. Our results suggest that intracellular domains are generated by gamma-secretase at the plasma membrane and/or early endosomes. ..
  49. Chappell W, Green T, Spengeman J, McCubrey J, Akula S, Bertrand F. Increased protein expression of the PTEN tumor suppressor in the presence of constitutively active Notch-1. Cell Cycle. 2005;4:1389-95 pubmed
    ..These data indicate that Notch-1 can participate in cross-talk with other signaling pathways such as Ras/Raf/MEK/ERK through the regulation of the PTEN tumor suppressor. ..
  50. Kindler T, Cornejo M, Scholl C, Liu J, Leeman D, Haydu J, et al. K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors. Blood. 2008;112:3373-82 pubmed publisher
    ..With progression of disease, approximately 50% of mice acquired Notch1 mutations within the PEST domain...
  51. Bae Y, Park H, Kim S, Kim J, Kang Y, Kim J, et al. Notch1 mediates visfatin-induced FGF-2 up-regulation and endothelial angiogenesis. Cardiovasc Res. 2011;89:436-45 pubmed publisher
    Our aims were to determine the role of Notch1 in mediating visfatin-induced angiogenesis and to explore potential target genes involved...
  52. Dotto G. Notch tumor suppressor function. Oncogene. 2008;27:5115-23 pubmed publisher
    ..The possibility that Notch signaling elicits a duality of signals, involved in growth/differentiation control and cell survival will be discussed, in the context of novel approaches for cancer therapy. ..
  53. Li H, Solomon E, Duhachek Muggy S, Sun D, Zolkiewska A. Metalloprotease-disintegrin ADAM12 expression is regulated by Notch signaling via microRNA-29. J Biol Chem. 2011;286:21500-10 pubmed publisher
    ..Expression of a constitutively active form of Notch1 in murine fibroblasts, myoblasts, or mammary epithelial cells or activation of the endogenous Notch signaling by ..
  54. Lim S, Kim H, Quan X, Ahn S, Kim H, Hsieh D, et al. Notch1 binds and induces degradation of Snail in hepatocellular carcinoma. BMC Biol. 2011;9:83 pubmed publisher
    ..Immunoprecipitation and subcellular colocalization studies were performed to confirm our identification of the Notch1 intracellular domain (NICD) as a novel Snail-binding partner...
  55. Saxena M, Schroeter E, Mumm J, Kopan R. Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis. J Biol Chem. 2001;276:40268-73 pubmed
    Oncogenic forms of Notch1, Notch2, and Notch4 appear to mimic signaling intermediates of Notch1 and suggest that the role of proteolysis in Notch signaling has been conserved...
  56. Tang Y, Urs S, Boucher J, Bernaiche T, Venkatesh D, Spicer D, et al. Notch and transforming growth factor-beta (TGFbeta) signaling pathways cooperatively regulate vascular smooth muscle cell differentiation. J Biol Chem. 2010;285:17556-63 pubmed publisher
    ..the intracellular domain of Notch4 interacted with phosphoSmad2/3 in SMC, this interaction was not observed with Notch1 or Notch2...
  57. Sjölund J, Johansson M, Manna S, Norin C, Pietras A, Beckman S, et al. Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo. J Clin Invest. 2008;118:217-28 pubmed
    ..These findings indicate that the Notch cascade may represent a novel and therapeutically accessible pathway in CCRCC. ..
  58. Balint K, Xiao M, Pinnix C, Soma A, Veres I, Juhasz I, et al. Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression. J Clin Invest. 2005;115:3166-76 pubmed
    ..Here we show that the Notch1 pathway is activated in human melanoma...
  59. Song J, Park S, Kim M, Shin I. Down-regulation of Notch-dependent transcription by Akt in vitro. FEBS Lett. 2008;582:1693-9 pubmed publisher
    ..These results may suggest possible regulation of NICD transcriptional activity by Akt-mediated phosphorylation and subsequent inhibition of proper nuclear localization of NICD. ..
  60. Lee S, Kumano K, Masuda S, Hangaishi A, Takita J, Nakazaki K, et al. Mutations of the Notch1 gene in T-cell acute lymphoblastic leukemia: analysis in adults and children. Leukemia. 2005;19:1841-3 pubmed
  61. McKellar S, Tester D, Yagubyan M, Majumdar R, Ackerman M, Sundt T. Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms. J Thorac Cardiovasc Surg. 2007;134:290-6 pubmed
    ..We, therefore, investigated the potential relationship between mutations in regions of NOTCH1 recently reported to be associated with bicuspid aortic valve and the phenotype of bicuspid aortic valve and ..
  62. De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm J, et al. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 1999;398:518-22 pubmed
    ..Thus the targeting of gamma-secretase for the treatment of Alzheimer's disease may risk toxicity caused by reduced Notch signalling. ..
  63. Baldus C, Thibaut J, Goekbuget N, Stroux A, Schlee C, Mossner M, et al. Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia. Haematologica. 2009;94:1383-90 pubmed publisher
    b>NOTCH1 mutations have been associated with a favorable outcome in pediatric acute T-lymphoblastic leukemia...
  64. Shutter J, Scully S, Fan W, Richards W, Kitajewski J, Deblandre G, et al. Dll4, a novel Notch ligand expressed in arterial endothelium. Genes Dev. 2000;14:1313-8 pubmed
    ..The activity and expression of Dll4 and the known actions of other members of this family suggest a role for Dll4 in the control of endothelial cell biology. ..
  65. Vooijs M, Schroeter E, Pan Y, Blandford M, Kopan R. Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization. J Biol Chem. 2004;279:50864-73 pubmed
    ..formation, most surface Notch molecules in mammalian cells are monomeric as are constitutively active or inactive Notch1 proteins...
  66. Nam Y, Sliz P, Song L, Aster J, Blacklow S. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell. 2006;124:973-83 pubmed the crystal structure of a Notch transcriptional activation complex containing the ankyrin domain of human Notch1 (ANK), the transcription factor CSL on cognate DNA, and a polypeptide from the coactivator Mastermind-like-1 (MAML-..
  67. Lu Z, Liu H, Xue L, Xu P, Gong T, Hou G. An activated Notch1 signaling pathway inhibits cell proliferation and induces apoptosis in human esophageal squamous cell carcinoma cell line EC9706. Int J Oncol. 2008;32:643-51 pubmed
    Previous studies have demonstrated that Notch1 signaling pathway plays a major role in maintaining the balance of cell proliferation, differentiation and apoptosis, and is closely associated with tumorigenesis...
  68. Bin Hafeez B, Adhami V, Asim M, Siddiqui I, Bhat K, Zhong W, et al. Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator. Clin Cancer Res. 2009;15:452-9 pubmed publisher
    ..Aberrant Notch signaling, found in a wide variety of human cancers, contributes to tumor development. Because Notch1 was found to be overexpressed in prostate cancer (PCa) cells and human PCa tissue, we therefore tested our ..
  69. Yoon J, Kim S, Kwon S, Park J, Park H, Kim Y, et al. 5'-Nitro-indirubinoxime induces G1 cell cycle arrest and apoptosis in salivary gland adenocarcinoma cells through the inhibition of Notch-1 signaling. Biochim Biophys Acta. 2010;1800:352-8 pubmed publisher
    ..This study identifies a new mechanism of 5'-NIO-mediated anti-tumor properties. Thus, 5'-NIO could be used as a candidate for salivary gland adenocarcinoma therapeutics. ..
  70. Du R, Sun W, Xia L, Zhao A, Yu Y, Zhao L, et al. Hypoxia-induced down-regulation of microRNA-34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells. PLoS ONE. 2012;7:e30771 pubmed publisher
    ..Transfection of miRNA-34a in HK-2 cells under hypoxia abolished hypoxia-induced expression of Notch1 and Jagged1 as well as Notch downstream signals, such as snail...
  71. Gray G, Mann R, Mitsiadis E, Henrique D, Carcangiu M, Banks A, et al. Human ligands of the Notch receptor. Am J Pathol. 1999;154:785-94 pubmed
  72. Blokzijl A, Dahlqvist C, Reissmann E, Falk A, Moliner A, Lendahl U, et al. Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3. J Cell Biol. 2003;163:723-8 pubmed
    ..regulated transcription from the Hes-1 promoter in a Notch-dependent manner, and the intracellular domain of Notch1 (NICD) cooperated synergistically with Smad3, an intracellular transducer of TGF-beta signals, to induce the ..
  73. Morrow D, Scheller A, Birney Y, Sweeney C, Guha S, Cummins P, et al. Notch-mediated CBF-1/RBP-J{kappa}-dependent regulation of human vascular smooth muscle cell phenotype in vitro. Am J Physiol Cell Physiol. 2005;289:C1188-96 pubmed
  74. Hopfer O, Zwahlen D, Fey M, Aebi S. The Notch pathway in ovarian carcinomas and adenomas. Br J Cancer. 2005;93:709-18 pubmed
    ..The Notch pathway could be a target for the development of therapies for ovarian cancer. ..
  75. Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, et al. Secretion of the Notch-1 Abeta-like peptide during Notch signaling. J Biol Chem. 2006;281:7890-8 pubmed
    ..We anticipate that this study will open the door to searches for markers of RIP signaling and surrogate markers for Abeta42 production. ..
  76. Guo D, Ye J, Dai J, Li L, Chen F, Ma D, et al. Notch-1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 in T-ALL cell lines. Leuk Res. 2009;33:678-85 pubmed publisher
    ..In addition, our results demonstrated that down-regulation of Notch-1 signaling could sensitize SupT1 cells to adriamycin. Taken together, cell cycle regulatory proteins and Akt signaling may be attractive targets in T-ALL. ..
  77. Villamor N, Conde L, Martínez Trillos A, Cazorla M, Navarro A, Bea S, et al. NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome. Leukemia. 2013;27:1100-6 pubmed publisher
    b>NOTCH1 has been found recurrently mutated in a subset of patients with chronic lymphocytic leukemia (CLL). To analyze biological features and clinical impact of NOTCH1 mutations in CLL, we sequenced this gene in 565 patients...
  78. Sakamoto K, Yamaguchi S, Ando R, Miyawaki A, Kabasawa Y, Takagi M, et al. The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway. J Biol Chem. 2002;277:29399-405 pubmed
    ..NOV associates with the epidermal growth factor-like repeats of Notch1 by the CT (C-terminal cysteine knot) domain...
  79. Bozkulak E, Weinmaster G. Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling. Mol Cell Biol. 2009;29:5679-95 pubmed publisher
    ..Our study provides new insight into this conflict, as we find that although Notch1 (N1) is a substrate for both ADAM10 and ADAM17, the particular ADAM required for receptor activation is context ..
  80. Ohashi S, Natsuizaka M, Yashiro Ohtani Y, Kalman R, Nakagawa M, Wu L, et al. NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network. Gastroenterology. 2010;139:2113-23 pubmed publisher
    ..b>NOTCH1 (N1) was activated at the onset of squamous differentiation in the esophagus...
  81. Matsuno K, Eastman D, Mitsiades T, Quinn A, Carcanciu M, Ordentlich P, et al. Human deltex is a conserved regulator of Notch signalling. Nat Genet. 1998;19:74-8 pubmed
    ..We present evidence linking deltex to the modulation of basic helix-loop-helix (bHLH) transcription factor activity. ..
  82. Fryer C, White J, Jones K. Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol Cell. 2004;16:509-20 pubmed
    ..These findings suggest a role for MAM and CycC:CDK8 in the turnover of the Notch enhancer complex at target genes. ..
  83. Skrtic A, Korac P, Krišto D, Ajduković Stojisavljević R, Ivankovic D, Dominis M. Immunohistochemical analysis of NOTCH1 and JAGGED1 expression in multiple myeloma and monoclonal gammopathy of undetermined significance. Hum Pathol. 2010;41:1702-10 pubmed publisher
    ..Notch signaling is implicated in the pathogenesis of multiple myeloma expressing high level of active Notch proteins NOTCH1 and JAGGED1 in tumor plasma cells...
  84. Thélu J, Rossio P, Favier B. Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing. BMC Dermatol. 2002;2:7 pubmed
    ..The Notch signalling involved in the differentiation programme of normal adult human epidermis is altered under experimental conditions and pathologies which modify this programme. ..
  85. Subramanyam D, Krishna S. c-Myc substitutes for Notch1-CBF1 functions in cooperative transformation with papillomavirus oncogenes. Virology. 2006;347:191-8 pubmed
    ..Here, we show that analogous to activated alleles of Notch1, c-Myc can cooperate with E6/E7 in epithelial transformation and can substitute for CBF1-dependent signals ..
  86. Yao J, Duan L, Fan M, Yuan J, Wu X. Notch1 induces cell cycle arrest and apoptosis in human cervical cancer cells: involvement of nuclear factor kappa B inhibition. Int J Gynecol Cancer. 2007;17:502-10 pubmed
    ..Our studies demonstrated that constitutively overexpressed active Notch1 via stable transfection with exogenous intracellular domain of Notch1 (ICN) resulted in growth inhibition of the ..
  87. Asnafi V, Buzyn A, Le Noir S, Baleydier F, Simon A, Beldjord K, et al. NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study. Blood. 2009;113:3918-24 pubmed publisher
    ..b>NOTCH1 and/or FBXW7 mutations both lead to activation of the NOTCH1 pathway and are among the most frequent mutations in ..
  88. Mamaeva V, Rosenholm J, Bate Eya L, Bergman L, Peuhu E, Duchanoy A, et al. Mesoporous silica nanoparticles as drug delivery systems for targeted inhibition of Notch signaling in cancer. Mol Ther. 2011;19:1538-46 pubmed publisher
    ..The data highlights MSNPs as an attractive platform for targeted drug delivery of anticancer drugs with otherwise restricted clinical application, and as interesting constituents in the quest for more refined Notch therapies. ..
  89. Qiu L, Joazeiro C, Fang N, Wang H, Elly C, Altman Y, et al. Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase. J Biol Chem. 2000;275:35734-7 pubmed
    ..Thus, Itch may participate in the regulation of immune responses by modifying Notch-mediated signaling. ..
  90. Nakano K, Siar C, Tsujigiwa H, Nagatsuka H, Nagai N, Kawakami T. Notch signaling in benign and malignant ameloblastic neoplasms. Eur J Med Res. 2008;13:476-80 pubmed
  91. Kox C, Zimmermann M, Stanulla M, Leible S, Schrappe M, Ludwig W, et al. The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL-BFM 2000 protocol can be separated from FBXW7 loss of function. Leukemia. 2010;24:2005-13 pubmed publisher
    ..Activating NOTCH1 mutations signify a favorable prognosis in patients treated on ALL-BFM protocols...
  92. Kim M, Jung J, Mo J, Ann E, Ahn J, Yoon J, et al. The intracellular domain of Jagged-1 interacts with Notch1 intracellular domain and promotes its degradation through Fbw7 E3 ligase. Exp Cell Res. 2011;317:2438-46 pubmed publisher
    ..In this study, we have demonstrated that the Jagged-1 intracellular domain (JICD) inhibits Notch1 signaling via a reduction in the protein stability of the Notch1 intracellular domain (Notch1-IC)...