Notch1

Summary

Gene Symbol: Notch1
Description: notch 1
Alias: AOS5, AOVD1, TAN1, hN1, neurogenic locus notch homolog protein 1, Notch homolog 1, translocation-associated, translocation-associated notch protein TAN-1
Species: human

Top Publications

  1. ncbi Deregulated expression of Notch receptors in human hepatocellular carcinoma
    J Gao
    Department of Digestive Diseases, Wuhan General Hospital, Guangzhou Command PLA, Wuhan, Hubei Province, PR China
    Dig Liver Dis 40:114-21. 2008
  2. pmc Notch1 represses osteogenic pathways in aortic valve cells
    Vishal Nigam
    Gladstone Institute of Cardiovascular Disease and Departments of Pediatrics, University of California, San Francisco, CA 94158, USA
    J Mol Cell Cardiol 47:828-34. 2009
  3. ncbi TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
    L W Ellisen
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Cell 66:649-61. 1991
  4. pmc Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells
    Bin Bao
    Department of Pathology, Wayne State University, Detroit, MI, USA
    Cancer Lett 307:26-36. 2011
  5. ncbi Notch signaling: cell fate control and signal integration in development
    S Artavanis-Tsakonas
    Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Science 284:770-6. 1999
  6. pmc Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia
    Maddalena Paganin
    Institute for Cancer Genetics, Columbia University, NY, USA
    Blood Rev 25:83-90. 2011
  7. ncbi Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
    Andrew P Weng
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 306:269-71. 2004
  8. pmc SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation
    G Wu
    Department of Pathology, Columbia University, New York, New York 10032, USA
    Mol Cell Biol 21:7403-15. 2001
  9. pmc NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
    Teresa Palomero
    Institute for Cancer Genetics and Joint Centers for Systems Biology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:18261-6. 2006
  10. pmc Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches
    Paola Rizzo
    Breast Cancer Program and Skin Cancer Program, Cardinal Bernardin Cancer Center, Loyola University Chicago
    Cancer Res 68:5226-35. 2008

Research Grants

  1. Role of Kruppel-Like Factor 4 in Wnt and Notch Signaling in the Intestinal Tract
    Amr Ghaleb; Fiscal Year: 2010
  2. Role of HES/HEY family of proteins in mammalian spermatogenesis
    MARIE CLAUDE CATHERINE HOFMANN; Fiscal Year: 2012
  3. Domenico Accili; Fiscal Year: 2016
  4. Gadiparthi N Rao; Fiscal Year: 2016
  5. Warren S Pear; Fiscal Year: 2016
  6. UTPAL BHAGIRATH PAJVANI; Fiscal Year: 2015
  7. 14-3-3?? and epithelial differentiation in the eye and other tissues
    Qiutang Li; Fiscal Year: 2012
  8. Physiologic Regulation of Hematopoiesis by Notch
    Nadia Carlesso; Fiscal Year: 2011
  9. John P Manis; Fiscal Year: 2016
  10. Molecular Mechanisms Underlying the Distinct Functions of Notch1 and Notch2
    Matthew R Hass; Fiscal Year: 2010

Detail Information

Publications337 found, 100 shown here

  1. ncbi Deregulated expression of Notch receptors in human hepatocellular carcinoma
    J Gao
    Department of Digestive Diseases, Wuhan General Hospital, Guangzhou Command PLA, Wuhan, Hubei Province, PR China
    Dig Liver Dis 40:114-21. 2008
    ..To address this, the expression of Notch receptors in human hepatocellular carcinoma was examined in both protein and ribonucleic acid levels...
  2. pmc Notch1 represses osteogenic pathways in aortic valve cells
    Vishal Nigam
    Gladstone Institute of Cardiovascular Disease and Departments of Pediatrics, University of California, San Francisco, CA 94158, USA
    J Mol Cell Cardiol 47:828-34. 2009
    ..We reported two families in which heterozygous mutations in NOTCH1 caused bicuspid aortic valve and severe aortic valve calcification...
  3. ncbi TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
    L W Ellisen
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Cell 66:649-61. 1991
    ..These observations suggest that TAN-1 may be important for normal lymphocyte function and that alteration of TAN-1 may play a role in the pathogenesis of some T cell neoplasms...
  4. pmc Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells
    Bin Bao
    Department of Pathology, Wayne State University, Detroit, MI, USA
    Cancer Lett 307:26-36. 2011
    ....
  5. ncbi Notch signaling: cell fate control and signal integration in development
    S Artavanis-Tsakonas
    Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Science 284:770-6. 1999
    ..Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis...
  6. pmc Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia
    Maddalena Paganin
    Institute for Cancer Genetics, Columbia University, NY, USA
    Blood Rev 25:83-90. 2011
    ..However, the identification of activating mutations in the NOTCH1 gene in over 50% of T-ALL cases has come to define aberrant NOTCH signaling as a central player in this disease...
  7. ncbi Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
    Andrew P Weng
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 306:269-71. 2004
    Very rare cases of human T cell acute lymphoblastic leukemia (T-ALL) harbor chromosomal translocations that involve NOTCH1, a gene encoding a transmembrane receptor that regulates normal T cell development...
  8. pmc SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation
    G Wu
    Department of Pathology, Columbia University, New York, New York 10032, USA
    Mol Cell Biol 21:7403-15. 2001
    ..In the case of Notch1, this block leads to an increase in Notch signaling stimulated by either an activated form of the Notch1 receptor ..
  9. pmc NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
    Teresa Palomero
    Institute for Cancer Genetics and Joint Centers for Systems Biology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:18261-6. 2006
    The NOTCH1 signaling pathway directly links extracellular signals with transcriptional responses in the cell nucleus and plays a critical role during T cell development and in the pathogenesis over 50% of human T cell lymphoblastic ..
  10. pmc Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches
    Paola Rizzo
    Breast Cancer Program and Skin Cancer Program, Cardinal Bernardin Cancer Center, Loyola University Chicago
    Cancer Res 68:5226-35. 2008
    ..Our data indicate that combinations of antiestrogens and Notch inhibitors may be effective in ERalpha(+) breast cancers and that Notch signaling is a potential therapeutic target in ERalpha(-) breast cancers...
  11. pmc HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway
    L Qiang
    Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, People s Republic of China
    Cell Death Differ 19:284-94. 2012
    ..These findings enhance our understanding of mechanism of hypoxia-mediated GSC expansion and provide HIF-1α as an attractive target for glioblastoma therapy...
  12. pmc CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7R{alpha} gene expression in early human thymopoiesis and leukemia
    Sara Gonzalez-Garcia
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Spain
    J Exp Med 206:779-91. 2009
    b>Notch1 activation is essential for T-lineage specification of lymphomyeloid progenitors seeding the thymus...
  13. doi Down-regulation of Notch-1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-kappaB signaling pathways
    Zhiwei Wang
    Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    J Cell Biochem 109:726-36. 2010
    ..Our results further suggest that inactivation of Notch signaling pathways by innovative strategies could be a potential targeted approach for the treatment of metastatic prostate cancer...
  14. ncbi Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor
    N Gupta-Rossi
    Unité de Biologie Moléculaire de l Expression Génique, FRE 2364, CNRS, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 276:34371-8. 2001
    ..We report that the nuclear intracellular domain of Notch1 is stabilized by proteasome inhibitors and is a substrate for polyubiquitination in vitro...
  15. pmc Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production
    Tobias Moehlmann
    Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s Disease Research, Ludwig Maximilians University, 80336 Munich, Germany
    Proc Natl Acad Sci U S A 99:8025-30. 2002
    ..Finally, we show that PS1 L166 mutants affect the generation of NICD and AICD in a similar manner, supporting the concept that S3 protease and S3-like gamma-secretase cleavages are mediated by identical proteolytic activities...
  16. ncbi Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover
    Christy J Fryer
    Regulatory Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Mol Cell 16:509-20. 2004
    ..These findings suggest a role for MAM and CycC:CDK8 in the turnover of the Notch enhancer complex at target genes...
  17. ncbi Oxygen concentration determines the biological effects of NOTCH-1 signaling in adenocarcinoma of the lung
    Yuanbin Chen
    Oncology Institute, Loyola University Chicago, Maywood, IL 60153, USA
    Cancer Res 67:7954-9. 2007
    ..Our data strengthen the role of NOTCH in lung cancer and as a therapeutic target for the treatment of lung and other hypoxic tumor types...
  18. doi Localization of the delta-like-1-binding site in human Notch-1 and its modulation by calcium affinity
    Jemima Cordle
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    J Biol Chem 283:11785-93. 2008
    ..This study therefore demonstrates that long range calcium-dependent structural perturbations can influence the affinity of Notch for its ligand, in the absence of any post-translational modifications...
  19. pmc Notch-1 signaling regulates intestinal epithelial barrier function, through interaction with CD4+ T cells, in mice and humans
    Stephanie Dahan
    Immunology Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Gastroenterology 140:550-9. 2011
    ..The absence of LPLs in mice, such as in RAG1(-/-) mice, results in defects in epithelial cell differentiation. We investigated the role of lymphoepithelial interactions in epithelial differentiation and barrier function...
  20. ncbi CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to gamma-secretase inhibitors
    T Palomero
    Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
    Leukemia 20:1279-87. 2006
    Activating mutations in NOTCH1 are present in over 50% of human T-cell lymphoblastic leukemia (T-ALL) samples and inhibition of NOTCH1 signaling with gamma-secretase inhibitors (GSI) has emerged as a potential therapeutic strategy for the ..
  21. ncbi MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors
    L Wu
    Department of Adult Oncology, Dana Farber Cancer Institute and Departments of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 26:484-9. 2000
    ..These studies provide a molecular mechanism to explain the genetic links between mastermind and Notch in Drosophila and indicate that MAML1 functions as a transcriptional co-activator for NOTCH signalling...
  22. ncbi Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms
    Stephen H McKellar
    Department of Surgery Division of Cardiovascular Surgery, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    J Thorac Cardiovasc Surg 134:290-6. 2007
    ..We, therefore, investigated the potential relationship between mutations in regions of NOTCH1 recently reported to be associated with bicuspid aortic valve and the phenotype of bicuspid aortic valve and ..
  23. ncbi Notch signaling in cancer
    Eric J Allenspach
    Departments of Pathology and Laboratory Medicine, Institute for Medicine and Engineering, Abramson Family Cancer Research Institute, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Cancer Biol Ther 1:466-76. 2002
    ..3) chromosomal translocation involving the human Notch1 gene that is found in a small subset of human pre-T-cell acute lymphoblastic leukemias (T-ALL)...
  24. pmc Notch tumor suppressor function
    G P Dotto
    Department of Biochemistry, Lausanne University, Epalinges, Switzerland
    Oncogene 27:5115-23. 2008
    ..The possibility that Notch signaling elicits a duality of signals, involved in growth/differentiation control and cell survival will be discussed, in the context of novel approaches for cancer therapy...
  25. doi NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951
    E Clappier
    Département de génétique, APHP, Hopital Robert Debre, Universite Paris 7 Denis Diderot, Paris, France
    Leukemia 24:2023-31. 2010
    ..We investigated the prognostic implication of hyperactivation of NOTCH pathway resulting from mutations of NOTCH1 or FBXW7 in children with T-ALL enrolled in EORTC-CLG trials...
  26. pmc The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL-BFM 2000 protocol can be separated from FBXW7 loss of function
    C Kox
    Department of Pediatric Oncology, Hematology and Immunology, Angelika Lautenschläger Children s Hospital, University of Heidelberg, Heidelberg, Germany
    Leukemia 24:2005-13. 2010
    ..Activating NOTCH1 mutations signify a favorable prognosis in patients treated on ALL-BFM protocols...
  27. pmc Notch1 is an effector of Akt and hypoxia in melanoma development
    Barbara Bedogni
    Division of Radiation and Cancer Biology, Stanford University, Stanford, California, USA
    J Clin Invest 118:3660-70. 2008
    ..Here we show that Notch1 signaling is elevated in human melanoma samples and cell lines and is required for Akt and hypoxia to transform ..
  28. pmc The Notch pathway in ovarian carcinomas and adenomas
    O Hopfer
    Department of Clinical Research, University of Bern, Bern, Switzerland
    Br J Cancer 93:709-18. 2005
    ..The Notch pathway could be a target for the development of therapies for ovarian cancer...
  29. pmc The significance of Notch1 compared with Notch3 in high metastasis and poor overall survival in hepatocellular carcinoma
    Liang Zhou
    Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi an, Shannxi, People s Republic of China
    PLoS ONE 8:e57382. 2013
    ..The prognosis for patients with hepatocellular carcinoma (HCC) is poor, and the mechanisms underlying the development of HCC remain unclear. Notch1 and Notch3 may be involved in malignant transformation, although their roles remain unknown.
  30. pmc Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness
    P Zhang
    Department of Pediatrics Research, Children s Cancer Hospital, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 29:2916-26. 2010
    ..This mechanism may have important clinical implications for targeting NOTCH signaling in osteosarcoma and other cancers...
  31. pmc Slug is a direct Notch target required for initiation of cardiac cushion cellularization
    Kyle Niessen
    Department of Medical Biophysics, British Columbia Cancer Agency, Vancouver V5Z 1L3, Canada
    J Cell Biol 182:315-25. 2008
    ..Collectively, our data suggest that combined expression of Slug and Snail is required for EMT in cardiac cushion morphogenesis...
  32. pmc Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression
    Klara Balint
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 115:3166-76. 2005
    ..Here we show that the Notch1 pathway is activated in human melanoma...
  33. pmc Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway
    S Eliasz
    Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153, USA
    Oncogene 29:2488-98. 2010
    ..Our data provide a mechanistic explanation for Notch-1-mediated pro-survival function in hypoxic ACL tumor microenvironment. The results identify additional targets that may synergize with Notch-1 inhibition for ACL treatment...
  34. pmc Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia
    Joanna Pancewicz
    Department of Pathology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Proc Natl Acad Sci U S A 107:16619-24. 2010
    ..domain leading to reduced CDC4/Fbw7-mediated degradation and stabilization of the intracellular cleaved form of Notch1 (ICN1)...
  35. doi Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase
    Jung Soon Mo
    Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 500 757, Republic of Korea
    J Cell Sci 124:100-12. 2011
    ..b>Notch1 and Fbw7 mutations both lead the activation of the Notch1 pathway and are found in the majority of patients with ..
  36. ncbi Novel missense mutations (p.T596M and p.P1797H) in NOTCH1 in patients with bicuspid aortic valve
    Salah A Mohamed
    Department of Cardiac Surgery, University of Schleswig Holstein, Campus Luebeck, Germany
    Biochem Biophys Res Commun 345:1460-5. 2006
    ..In a recent report, mutations in NOTCH1 a signaling and transcriptional regulator have been shown to cause BAV in two families...
  37. pmc Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes
    Michael J Malecki
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 26:4642-51. 2006
    The NOTCH1 receptor is cleaved within its extracellular domain by furin during its maturation, yielding two subunits that are held together noncovalently by a juxtamembrane heterodimerization (HD) domain...
  38. pmc Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site
    Yuefeng Tang
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME 04074, USA
    Circ Res 102:661-8. 2008
    ..Using primary human smooth muscle cells, we show that expression of the constitutive active ICD of human Notch1, Notch2, or Notch4 receptors increase SMA levels...
  39. ncbi Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis
    Runzi Qi
    Institute of Immunology, Second Military Medical University, Shanghai, People s Republic of China
    Cancer Res 63:8323-9. 2003
    ..We constitutively overexpressed active Notch1 in human HCC to explore the effects of Notch1 signaling on HCC cell growth and to investigate the underlying ..
  40. pmc The roles of Notch1 expression in the migration of intrahepatic cholangiocarcinoma
    Qi Zhou
    Department of Hepatobiliary Surgery, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou, Guangdong, China
    BMC Cancer 13:244. 2013
    ..In this study, we evaluated the expression and effects of Notch1 on cell migration in ICC.
  41. pmc Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats
    Cheryll Sanchez-Irizarry
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Mol Cell Biol 24:9265-73. 2004
    ..Together, these two contiguous regions of N(EC) impose crucial restraints that prevent premature Notch receptor activation...
  42. pmc Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator
    Bilal Bin Hafeez
    Department of Dermatology, University of Wisconsin, 1300 University Avenue, Medical Science Center, B 25, Madison, WI 53706, USA
    Clin Cancer Res 15:452-9. 2009
    ..Aberrant Notch signaling, found in a wide variety of human cancers, contributes to tumor development. Because Notch1 was found to be overexpressed in prostate cancer (PCa) cells and human PCa tissue, we therefore tested our ..
  43. ncbi Overexpressed active Notch1 induces cell growth arrest of HeLa cervical carcinoma cells
    L Wang
    Department of Obstetrics and Gynecology, Xijing Hospital, The Fourth Military Medical University, Xi an, People s Republic of China
    Int J Gynecol Cancer 17:1283-92. 2007
    ..We now show that Notch1 is detected in all cervical cancer, including advanced diseases...
  44. doi Requirement of Notch activation during regeneration of the intestinal epithelia
    Ryuichi Okamoto
    Dept of Advanced Therapeutics in Gastrointestinal Diseases, Graduate School, Tokyo Medical and Dental Univ, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Am J Physiol Gastrointest Liver Physiol 296:G23-35. 2009
    ..gene expression and microarray analysis, we identified a novel group of genes that are regulated downstream of Notch1 within intestinal epithelial cells, including PLA2G2A, an antimicrobial peptide secreted by Paneth cells...
  45. pmc Notch inhibits expression of the Krüppel-like factor 4 tumor suppressor in the intestinal epithelium
    Amr M Ghaleb
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Mol Cancer Res 6:1920-7. 2008
    ..KLF4 is therefore a potential mediator for the antitumor effect of Notch inhibitors such as dibenzazepine...
  46. doi Association of high levels of Jagged-1 and Notch-1 expression with poor prognosis in head and neck cancer
    Jen Tsun Lin
    Department of Medicine, Chang Gung Memorial Hospital, Chia Yi, Taiwan
    Ann Surg Oncol 17:2976-83. 2010
    ..The aim of this study was to evaluate the prognostic value of the Jagged-1/Notch-1 expression in patients with head and neck carcinoma and to examine the possible role of the Jagged-1/Notch-1 signaling in tumorigenesis...
  47. pmc Specific knockdown of uPA/uPAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of Notch -1 receptor
    Hari Raghu
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine, One Illini Drive, Peoria, IL 61605, USA
    Mol Cancer 10:130. 2011
    ..Previous studies from our lab have also shown that uPA/uPAR down regulation inhibits cancer cell invasion in SNB 19 GBM cells...
  48. ncbi Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor
    N Yamamoto
    Department of Neurobiology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Biol Chem 276:45031-40. 2001
    ..Thus, DTX1 serves as an important signaling component downstream of Notch that regulates transcription in the nucleus...
  49. doi Notch signaling through Jagged-1 is necessary to initiate chondrogenesis in human bone marrow stromal cells but must be switched off to complete chondrogenesis
    Rachel A Oldershaw
    UK Centre for Tissue Engineering, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom
    Stem Cells 26:666-74. 2008
    ..The results thus showed that Jag-1-mediated Notch signaling in hMSC was necessary to initiate chondrogenesis, but it must be switched off for chondrogenesis to proceed...
  50. pmc The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group
    A Larson Gedman
    Graduate Program in Cancer Biology, Wayne State University School of Medicine, Detroit, MI, USA
    Leukemia 23:1417-25. 2009
    We explored the impact of mutations in the NOTCH1, FBW7 and PTEN genes on prognosis and downstream signaling in a well-defined cohort of 47 patients with pediatric T-cell acute lymphoblastic leukemia (T-ALL)...
  51. pmc Notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression
    Chunmei Wang
    National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, Department of Surgery, Changzheng Hospital, Shanghai 200433, China
    J Biol Chem 284:16183-90. 2009
    ..Our previous study showed that overexpression of Notch1 could inhibit human hepatocellular carcinoma (HCC) cell growth by arresting the cell cycle and inducing apoptosis...
  52. ncbi Glycogen synthase kinase-3beta modulates notch signaling and stability
    Daniel R Foltz
    Department of Molecular Pharmacology and Biological Chemistry, Chicago, IL 60611, USA
    Curr Biol 12:1006-11. 2002
    ..Functionally, ligand-activated signaling through the endogenous Notch1 receptor was reduced in GSK3beta null fibroblasts, implying a positive role for GSK3beta in mammalian Notch ..
  53. ncbi Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells
    Xue Ping Zhang
    Department of Medical Genetics and Developmental Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xian, PR China
    Mol Cell Biochem 307:101-8. 2008
    ..BT325, U251, SHG-44, and U87, mRNA encoding different types of Notch receptors were detected, but active form of Notch1 (NIC) was only detected in SHG-44 and U87 by Western blot...
  54. pmc Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia
    Teresa Palomero
    Institute for Cancer Genetics, Columbia University, New York, New York 10032, USA
    Nat Med 13:1203-10. 2007
    Gain-of-function mutations in NOTCH1 are common in T-cell lymphoblastic leukemias and lymphomas (T-ALL), making this receptor a promising target for drugs such as gamma-secretase inhibitors, which block a proteolytic cleavage required for ..
  55. ncbi Cell-cell signaling through NOTCH regulates human embryonic stem cell proliferation
    Victoria Fox
    Centre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
    Stem Cells 26:715-23. 2008
    ..Cleavage of both NOTCH1 and NOTCH2 to yield the intracellular domain responsible for the canonical signaling pathway of NOTCH was detected ..
  56. doi MicroRNA-34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme
    Wen bo Li
    Tianjin Medical University Eye Center, China
    Cancer Biol Ther 12:477-83. 2011
    ..Overexpression of miR-34a could induce apoptosis of glioblastoma cells. Also, we identified notch1 as a direct target gene of miR-34a...
  57. pmc High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling
    Hind Medyouf
    Terry Fox Laboratory Department of Pathology, BC Cancer Agency, Vancouver, BC, V52 1L3 Canada
    J Exp Med 208:1809-22. 2011
    ..lymphoblastic leukemia (T-ALL) is an aggressive cancer of immature T cells that often shows aberrant activation of Notch1 and PI3K-Akt pathways...
  58. ncbi Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription
    J C Aster
    Departments of Pathology, and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:11336-43. 1997
    Truncated forms of the NOTCH1 transmembrane receptor engineered to resemble mutant forms of NOTCH1 found in certain cases of human T cell leukemia/lymphoma (T-ALL) efficiently induce T-ALL when expressed in the bone marrow of mice...
  59. pmc Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis
    Salvatore Pece
    Istituto Europeo di Oncologia, 20141 Milan, Italy
    J Cell Biol 167:215-21. 2004
    ..Thus, the Numb/Notch biological antagonism is relevant to the homeostasis of the normal mammary parenchyma and its subversion contributes to human mammary carcinogenesis...
  60. ncbi Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras
    Philip S Hodkinson
    University of Edinburgh, MRC Centre for Inflammation Research, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4SA, Scotland, United Kingdom
    J Biol Chem 282:28991-9001. 2007
    ..This new CSL-independent Notch/R-Ras pathway provides a molecular mechanism to explain Notch, integrin, and Ras cross-talk during the development of multicellular organisms...
  61. doi The Notch pathway in podocytes plays a role in the development of glomerular disease
    Thiruvur Niranjan
    Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York 10461, USA
    Nat Med 14:290-8. 2008
    ..Expression of the intracellular domain of Notch1 (ICN1) was increased in glomerular epithelial cells in diabetic nephropathy and in focal segmental ..
  62. doi ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor
    C Osipo
    Department of Pathology, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL 60153, USA
    Oncogene 27:5019-32. 2008
    ..These results suggest that Notch-1 might play a novel role in resistance to trastuzumab, which could be prevented or reversed by inhibiting Notch-1...
  63. pmc Notch1 augments NF-kappaB activity by facilitating its nuclear retention
    Hyun Mu Shin
    Molecular and Cellular Biology Program, University of Massachusetts Amherst, Amherst, MA 01003, USA
    EMBO J 25:129-38. 2006
    b>Notch1 specifically upregulates expression of the cytokine interferon-gamma in peripheral T cells through activation of NF-kappaB. However, how Notch mediates NF-kappaB activation remains unclear...
  64. pmc The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
    Benjamin J Thompson
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 204:1825-35. 2007
    Recent studies have shown that activating mutations of NOTCH1 are responsible for the majority of T cell acute lymphoblastic leukemia (T-ALL) cases...
  65. pmc Squamous odontogenic tumor of the mandible: a case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1
    C H Siar
    Department of Oral Pathology, Oral Medicine and Periodontology, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
    Eur J Med Res 15:180-4. 2010
    ..Although Notch receptors and ligands have been shown to play a role in cell fate decisions in ameloblastomas, the role of these cell signaling molecules in SOT is unknown...
  66. ncbi NOTCH1 mutations in T-cell acute lymphoblastic leukemia: prognostic significance and implication in multifactorial leukemogenesis
    Yong Mei Zhu
    State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology, Shanghai Rui Jin Hospital, Medical School of Shanghai Jiao Tong University, Shanghai, China
    Clin Cancer Res 12:3043-9. 2006
    NOTCH signaling pathway is essential in T-cell development and NOTCH1 mutations are frequently present in T-cell acute lymphoblastic leukemia (T-ALL)...
  67. ncbi An activated Notch1 signaling pathway inhibits cell proliferation and induces apoptosis in human esophageal squamous cell carcinoma cell line EC9706
    Zhaoming Lu
    Laboratory for Cell Biology, The First Affiliated Hospital, Zhengzhou University, Henan 450052, PR China
    Int J Oncol 32:643-51. 2008
    Previous studies have demonstrated that Notch1 signaling pathway plays a major role in maintaining the balance of cell proliferation, differentiation and apoptosis, and is closely associated with tumorigenesis...
  68. doi Down-regulation of Notch-dependent transcription by Akt in vitro
    Jieun Song
    Department of Life Science, College of Natural Science, Hanyang University, 17 Haengdang dong, Seongdong Gu, Seoul 133 791, Republic of Korea
    FEBS Lett 582:1693-9. 2008
    ..These results may suggest possible regulation of NICD transcriptional activity by Akt-mediated phosphorylation and subsequent inhibition of proper nuclear localization of NICD...
  69. ncbi Correlation of Notch1 expression and activation to cisplatin-sensitivity of head and neck squamous cell carcinoma
    Zu Ping Zhang
    The First Department of Head and Neck, Tianjin Medical University, Tianjin, PR China
    Ai Zheng 28:100-3. 2009
    b>Notch1 belongs to the Notch family of transmembrane receptors and plays an important role in tumor cell proliferation and apoptosis. Notch1 affects chemosensitivity of tumors...
  70. doi Notch1 mediates visfatin-induced FGF-2 up-regulation and endothelial angiogenesis
    Yun Hee Bae
    Department of Physiology, School of Medicine, Yangsan Campus of Pusan National University, Yangsan 626 870, Republic of Korea
    Cardiovasc Res 89:436-45. 2011
    Our aims were to determine the role of Notch1 in mediating visfatin-induced angiogenesis and to explore potential target genes involved.
  71. pmc Metalloprotease-disintegrin ADAM12 expression is regulated by Notch signaling via microRNA-29
    Hui Li
    Department of Biochemistry, Kansas State University, Manhattan, Kansas 66506, USA
    J Biol Chem 286:21500-10. 2011
    ..Expression of a constitutively active form of Notch1 in murine fibroblasts, myoblasts, or mammary epithelial cells or activation of the endogenous Notch signaling by ..
  72. doi The intracellular domain of Jagged-1 interacts with Notch1 intracellular domain and promotes its degradation through Fbw7 E3 ligase
    Mi Yeon Kim
    Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Republic of Korea
    Exp Cell Res 317:2438-46. 2011
    ..In this study, we have demonstrated that the Jagged-1 intracellular domain (JICD) inhibits Notch1 signaling via a reduction in the protein stability of the Notch1 intracellular domain (Notch1-IC)...
  73. pmc Notch1 binds and induces degradation of Snail in hepatocellular carcinoma
    Seung Oe Lim
    Department of Biological Sciences, Seoul National University, 1 Gwanak ro, Gwanak Gu, Seoul, 151 747, Korea
    BMC Biol 9:83. 2011
    ....
  74. pmc Effect of mesenchymal stem cells and a novel curcumin derivative on Notch1 signaling in hepatoma cell line
    Mohamed Talaat Abdel Aziz
    Unit of Biochemistry and Molecular Biology UBMB, Department of Medical Biochemistry, Faculty of Medicine, Cairo University, Cairo 11956, Egypt
    Biomed Res Int 2013:129629. 2013
    ..and a novel curcumin derivative (NCD) on HepG2 cells (hepatoma cell line) and to investigate their effect on Notch1 signaling pathway target genes...
  75. pmc Noncanonical activation of Notch1 protein by membrane type 1 matrix metalloproteinase (MT1-MMP) controls melanoma cell proliferation
    Jun Ma
    From the Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 and
    J Biol Chem 289:8442-9. 2014
    b>Notch1 is an evolutionarily conserved signaling molecule required for stem cell maintenance that is inappropriately reactivated in several cancers...
  76. ncbi Down-regulation of Notch-1 expression decreases PU.1-mediated myeloid differentiation signaling in acute myeloid leukemia
    Po Min Chen
    Division of Hematology Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan R O C
    Int J Oncol 32:1335-41. 2008
    ..These results suggest that down-regulation of Notch-1 expression decreases PU.1/MCSFR expression and disrupts the Notch-1/PU.1 complex, which may impede the PU.1-mediated myeloid signaling and contribute to the leukemogenesis of AML...
  77. doi Notch-1 associates with IKKalpha and regulates IKK activity in cervical cancer cells
    L L Song
    Breast Cancer Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153, USA
    Oncogene 27:5833-44. 2008
    ..Our data indicate that Notch-1 regulates NF-kappaB in cervical cancer cells at least in part via cytoplasmic and nuclear IKK-mediated pathways...
  78. pmc Notch-1 signalling is activated in brain arteriovenous malformations in humans
    Qichuan ZhuGe
    Department of Neurosurgery, First Affiliated Hospital, Wenzhou Medical College, Wenzhou, China
    Brain 132:3231-41. 2009
    ....
  79. ncbi RNAi-mediated knockdown of Notch-1 leads to cell growth inhibition and enhanced chemosensitivity in human breast cancer
    Shaolei Zang
    Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, PR China
    Oncol Rep 23:893-9. 2010
    ..In addition, the down-regulation of Notch-1 signaling increased chemosensitivity to doxorubicin and docetaxel. Our results suggested that Notch signaling may be a promising target for breast cancer treatment...
  80. ncbi Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis
    N Kishi
    Division of Neuroanatomy, Department of Neuroscience, Biomedical Research Center, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, 565 0871, Osaka, Japan
    Int J Dev Neurosci 19:21-35. 2001
    ..genes were expressed in the central, peripheral nervous system and in the thymus, overlapping with those of mouse Notch1. In mammalian tissue culture cells, overexpression of any of the four mouse deltex homologs suppressed the ..
  81. ncbi Involvement of Notch-1 signaling in bone marrow stroma-mediated de novo drug resistance of myeloma and other malignant lymphoid cell lines
    Yulia Nefedova
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    Blood 103:3503-10. 2004
    ..Thus, this is a first report demonstrating that Notch-1 signaling may be a primary mechanism mediating the BMS influence on hematologic malignant cell growth and survival...
  82. pmc Calcium depletion dissociates and activates heterodimeric notch receptors
    M D Rand
    Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Mol Cell Biol 20:1825-35. 2000
    ..In the current work, we show that the N(EC) and N(TM) subunits of Drosophila Notch and human Notch1 (hN1) interact noncovalently. N(EC)-N(TM) interaction was disrupted by 0...
  83. ncbi Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase
    L Qiu
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 275:35734-7. 2000
    ..Thus, Itch may participate in the regulation of immune responses by modifying Notch-mediated signaling...
  84. ncbi Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma
    Franziska Jundt
    Charite, Robert Rossle Klinik, Humboldt University of Berlin, Germany
    Blood 99:3398-403. 2002
    ..In addition, truncated Notch1 alleles could be associated with 10% of all cases of human T lymphoblastic leukemia and, when introduced into ..
  85. ncbi Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes
    Yunsun Nam
    Biological and Biomedical Sciences Graduate Program in the Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA
    Cell 124:973-83. 2006
    ..here the crystal structure of a Notch transcriptional activation complex containing the ankyrin domain of human Notch1 (ANK), the transcription factor CSL on cognate DNA, and a polypeptide from the coactivator Mastermind-like-1 (MAML-..
  86. pmc FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors
    Jennifer O'Neil
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Exp Med 204:1813-24. 2007
    ..expression of the NOTCH intracellular domain (NICD), but that lacked C-terminal truncating mutations in NOTCH1. Each of the seven cell lines examined and 7 of 81 (8...
  87. pmc A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition
    Jemima Cordle
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Nat Struct Mol Biol 15:849-57. 2008
    ..Our data imply that cis- and trans-regulation may occur through the formation of structurally distinct complexes that, unexpectedly, involve the same surfaces on both ligand and receptor...
  88. pmc Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells
    L Hao
    Breast Cancer Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL, USA
    Oncogene 29:201-13. 2010
    ..Our observations suggest that a hitherto unknown Notch-1/ERalpha chromatin crosstalk mediates Notch signaling effects in ERalpha-positive breast cancer cells and contributes to regulate the transcriptional functions of ERalpha itself...
  89. pmc Interaction of hypoxia-inducible factor-1α and Notch signaling regulates medulloblastoma precursor proliferation and fate
    Francesca Pistollato
    SSD Clinical and Experimental Hematology, Department of Paediatrics, University of Padova, Padova, Italy
    Stem Cells 28:1918-29. 2010
    ..Here, we investigate whether hypoxia, through HIF-1α stabilization, modulates Notch1 signaling in primary MDB-derived cells...
  90. ncbi Aspartyl-asparagyl beta hydroxylase over-expression in human hepatoma is linked to activation of insulin-like growth factor and notch signaling mechanisms
    M Chiara Cantarini
    Department of Medicine, Rhode Island Hospital, Brown Medical School, Providence, RI 02903, USA
    Hepatology 44:446-57. 2006
    ..The functional role of AAH in relation to cell motility has been linked to increased activation of the Notch signaling pathway...
  91. ncbi Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
    C M Blaumueller
    Department of Cell Biology and Biology, Boyer Center for Molecular Medicine, Yale University, New Haven, Connecticut 06536 0812, USA
    Cell 90:281-91. 1997
    ..We provide evidence that these fragments are tethered together on the plasma membrane by a link that is sensitive to reducing conditions, forming a heterodimeric receptor...
  92. pmc The Notch1 receptor is cleaved constitutively by a furin-like convertase
    F Logeat
    Unité de Biologie Moléculaire de l Expression Génique, Unité de Recherche Associée 1773 Centre National de la Recherche Scientifique, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 95:8108-12. 1998
    ..We report here that constitutive processing of murine Notch1 involves a furin-like convertase...
  93. pmc Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing
    Jacques Thélu
    LEDAC, CNRS 5538, Institut A, Bonniot, Université J, Fourier, Grenoble, France
    BMC Dermatol 2:7. 2002
    ..This pathway is characterised by cell-cell interactions between transmembrane proteins and was first implicated in lateral inhibition, patterning and cell binary choices during embryogenesis...
  94. ncbi The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells
    Hadassah Sade
    National Centre for Biological Sciences, University of Agricultural Sciences Gandhi Krishi Vignan Kendra Campus, New Bellary Road, Bangalore 560065, Karnataka, India
    J Biol Chem 279:2937-44. 2004
    ..that endogenous Notch-1 associates with p56(lck) and PI3K but that Akt/PKB does not co-immunoprecipitate with the Notch1.p56(lck).PI3K complex. Finally, we demonstrate that the Notch1.p56(lck)...
  95. pmc Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3
    Andries Blokzijl
    Department of Neuroscience, Karoliska Institute, 17177 Stockholm, Sweden
    J Cell Biol 163:723-8. 2003
    ..regulated transcription from the Hes-1 promoter in a Notch-dependent manner, and the intracellular domain of Notch1 (NICD) cooperated synergistically with Smad3, an intracellular transducer of TGF-beta signals, to induce the ..
  96. pmc Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism
    Ayyakannu Ayyanan
    Swiss Institute for Experimental Cancer Research, National Center of Competence in Research in Molecular Oncology, 155 Chemin des Boveresses, CH 1066 Epalinges Lausanne, Switzerland
    Proc Natl Acad Sci U S A 103:3799-804. 2006
    ....
  97. ncbi Survival signaling by Notch1: mammalian target of rapamycin (mTOR)-dependent inhibition of p53
    Sathish Kumar Mungamuri
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India
    Cancer Res 66:4715-24. 2006
    ..Here, we show that cells expressing intracellular domain of human Notch1 (NIC-1) are chemoresistant in a wild-type p53-dependent manner...
  98. ncbi Zinc-induced downregulation of Notch signaling is associated with cytoplasmic retention of Notch1-IC and RBP-Jk via PI3k-Akt signaling pathway
    Sang Hyun Baek
    Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, 300, Yongbong Dong, Buk Ku, Gwangju, Republic of Korea
    Cancer Lett 255:117-26. 2007
    ..that the inactivation of Notch signaling by zinc is achieved via a PI3K-Akt-dependent, cytoplasmic retention of Notch1-IC and RBP-Jk...
  99. ncbi A role for notch signaling in human corneal epithelial cell differentiation and proliferation
    Aihua Ma
    Cell and Molecular Biology Unit, School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 48:3576-85. 2007
    ..To identify the role of Notch signaling in the human corneal epithelium...
  100. doi FBXW7 and NOTCH1 mutations in childhood T cell acute lymphoblastic leukaemia and T cell non-Hodgkin lymphoma
    Myoung Ja Park
    Department of Haematology Oncology, Gunma Children s Medical Centre, Gunma, Japan
    Br J Haematol 145:198-206. 2009
    Mutation analysis of FBXW7 and NOTCH1 genes was performed in 55 T cell acute lymphoblastic leukaemia (T-ALL) and 14 T cell non-Hodgkin lymphoma (T-NHL) patients who were treated on the Japan Association of Childhood Leukaemia Study (JACLS)..
  101. pmc Prognostic implications of NOTCH1 and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993 protocol
    Marc R Mansour
    Department of Haematology, University College London, UCL Cancer Institute, WC1E 6BT, United Kingdom
    J Clin Oncol 27:4352-6. 2009
    Notch pathway activation by mutations in either NOTCH1 and/or FBXW7 is one of the most common molecular events in T-cell acute lymphoblastic leukemia (T-ALL) and, in pediatric disease, predicts for favorable outcome...

Research Grants71

  1. Role of Kruppel-Like Factor 4 in Wnt and Notch Signaling in the Intestinal Tract
    Amr Ghaleb; Fiscal Year: 2010
    ..Several reports have shown the existence of cross-talk between Notch and Wnt pathways and that Wnt increases Notch1 expression...
  2. Role of HES/HEY family of proteins in mammalian spermatogenesis
    MARIE CLAUDE CATHERINE HOFMANN; Fiscal Year: 2012
    ..However to date, the exact role of Notch signaling in the testis is unknown. The Notch proteins (Notch1-4) are large cell-surface receptors that are activated by contact with membrane-bound ligands on neighboring cells,..
  3. Domenico Accili; Fiscal Year: 2016
    ..We show in preliminary data that Notch1 and Foxo1 cooperate to regulate hepatic glucose metabolism...
  4. Gadiparthi N Rao; Fiscal Year: 2016
    ..of pathological retinal angiogenesis, we have discovered that besides VEGFA, VEGFB, VEGFC, DLL4 and cleaved NOTCH1 induction, hypoxia activates CREB and STAT3 in the mouse retina in a robust and sustained manner...
  5. Warren S Pear; Fiscal Year: 2016
    ..applicant): The long-term goal of the work described in this competitive renewal application is to understand how Notch1 functions in T cell development and differentiation in order to develop new approaches for manipulating Notch ..
  6. UTPAL BHAGIRATH PAJVANI; Fiscal Year: 2015
    ..Through detailed metabolic analyses in compound haploinsufficient (FoxO1:Notch1) mice, Dr...
  7. 14-3-3?? and epithelial differentiation in the eye and other tissues
    Qiutang Li; Fiscal Year: 2012
    ..Accordingly when Notch1 is mutated, progenitors in the cornea, meibomian gland and hair follicles fail to differentiate and they ..
  8. Physiologic Regulation of Hematopoiesis by Notch
    Nadia Carlesso; Fiscal Year: 2011
    ..We have recently identified the molecular mechanism that mediates this effect. We discovered that Notch1 activation induces the transcriptional activation of SKP2, the F-box subunit of the SCFskp2 complex that targets ..
  9. John P Manis; Fiscal Year: 2016
    ..Co-culture of human hematopoietic stem cells (HSCs) with mouse OP9 stromal cells engineered to express the Notch1 ligands Delta-like 1 (Dll1) or Delta-like 4 (Dll4) has been used to study T cell differentiation...
  10. Molecular Mechanisms Underlying the Distinct Functions of Notch1 and Notch2
    Matthew R Hass; Fiscal Year: 2010
    ....
  11. Iannis Aifantis; Fiscal Year: 2014
    ..of ALL patients and induce transformation due to the aberrant stability of several important oncogenes, including Notch1 and c-Myc. We have addressed the role of Fbw7 in HSC function using a novel conditional knock-out mouse model...
  12. John J Laterra; Fiscal Year: 2015
    ..These tumor suppressing effects of KLF9 were found to result in part from the direct repression of Notch1 transcription...
  13. Chia Yang Liu; Fiscal Year: 2015
    ..Herein, we have investigated the effects of Notch1 signaling activation in peri-ocular mesenchymal cells (POMC) which contribute to the formation of the lid-specific ..
  14. Towards a Mouse Model of Classical Hodgkin's Disease and PTLD
    FREDERICK WAYNE ALT; Fiscal Year: 2013
    ..the interference of certain transcription factors (TFs) known to be expressed in HRS cells, namely Id2, ABF1 and Notch1, with the B cell- specific gene expression program...
  15. Anand Venugopal; Fiscal Year: 2015
    ..b>Notch1 is a transmembrane signaling receptor...
  16. The Mechanism of Cryptorchidism in LH Receptor Knockout Animals
    Zhenmin Lei; Fiscal Year: 2012
    ..development, such as Hoxa10, Hoxa11, Wt1, Dll1 and Desrt, were not altered in mutant mice, while Lgr8, Notch1 and Numb mRNA levels were drastically deceased as compared with age-matched wild type siblings...
  17. Yousef Abu-Amer; Fiscal Year: 2016
    ..with these observations, we established that exogenous expression of NUMBL induces degradation of TRAF6, NEMO, NOTCH1-NICD, and inhibits osteoclastogenesis in vitro...
  18. Nadean L Brown; Fiscal Year: 2016
    ..Findings here will also be widely useful to the field of cancer biology, since excess activated Notch1 or Hes1 expression occurs in a variety of human tumors...
  19. Gordon S Huggins; Fiscal Year: 2015
    ..BAV and CAVD are regulated by genetic factors including mutations in the Notch1 gene. We analyzed human genetic datasets to identify gene variants associated with BAV and/or CAVD...
  20. Angelika Doetzlhofer; Fiscal Year: 2016
    ..We will test if induction of an activated form of the Notch1 receptor is sufficient to induce supporting cell fate and whether inhibition of Notch signaling with 3-secretase ..
  21. Jun Dai; Fiscal Year: 2015
    ..We recently showed that the forkhead transcription factor FOXN1 and the Notch1 signaling pathways are functionally linked to suppression of malignant skin tumor formation...
  22. Ernesto Canalis; Fiscal Year: 2016
    ..mouse and cellular models expressing Notch in the osteocyte environment, and models of conditional inactivation of Notch1 and Notch2 in osteocytes...
  23. Stat5b in Lymphomagenesis: Mechanistic and Therapeutic Implications
    John A Kelly; Fiscal Year: 2012
    ..We will determine the contribution of Notch1, growth factors and cytokine signaling to the process...
  24. Rong Wang; Fiscal Year: 2015
    ..Aim 4 Determine the requirement of endothelial Notch1 and Coup-TFII in AV specification of adult parallel artery and vein pairs...
  25. Thomas W Kensler; Fiscal Year: 2015
    ..genes but importantly cross- talk with other adaptive response signaling networks affecting cell fate, such as Notch1. The overall goals of the proposed studies are two-fold: to assess the underlying mechanisms and consequences of ..
  26. Functional study of novel transcriptional regulators of hematopoietic stem cells
    Shannon L McKinney-Freeman; Fiscal Year: 2012
    ..e. VEGF, Stat5, Notch1)...
  27. Mechanisms of Lymphocyte Gene Regulation by E2A and Notch1
    BARBARA LYNNE KEE; Fiscal Year: 2010
    ..abstract_text> ..
  28. Nadean L Brown; Fiscal Year: 2016
    ..Interestingly, Notch1-/-, Notch2-/- and Jagged1 mutant mice each have prenatal eye phenotypes, but little is known about the roles of ..
  29. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford C Berk; Fiscal Year: 2012
    ..data show essential roles for GIT1 in multiple VEGF signaling events, especially those mediated by the Delta4- Notch1 pathway, we propose that GIT1 is a novel mediator of VEGF-dependent signaling (via PLC3, ERK1/2 and Delta4-Notch) ..
  30. A Thomas Look; Fiscal Year: 2014
    ..In Project 2, Harald von Boehmer will identify molecular pathways that cooperate with Notch1 signaling in lymphomagenesis by analyzing the impact of insertional mutagenesis, epigenetic regulation, and miRNA-..
  31. Adolfo A Ferrando; Fiscal Year: 2016
    ..Activating mutations in NOTCH1 have been recently found in 10-15% of CLL cases and are associated with poor prognosis, disease progression, ..
  32. Role of 14-3-3o in development and repair of corneal epithelium
    Qiutang Li; Fiscal Year: 2013
    ..b>Notch1 is essential for corneal epithelial differentiation via its activation of genes important for both differentiation ..
  33. Iannis Aifantis; Fiscal Year: 2016
    ..Recent evidence demonstrated that activating mutations in the Notch1 oncogene are the trigger for cell transformation in the majority of T-ALL patients...
  34. Aleksandar Milosavljevic; Fiscal Year: 2016
    ..leading to copy number variation in the tumors that cause specific driver mutations such as activated NOTCH1 through recombination...
  35. Mechanisms of T-Cell Leukemogenesis Induced by Notch1
    Adolfo A Ferrando; Fiscal Year: 2011
    ..pathogenesis of more than 50% of human T-cell lymphoblastic leukemias (T-ALL), in which activating mutations in NOTCH1 result in constitutive NOTCH signaling...
  36. The role of AKT signaling in NOTCH1 induced leukemias
    Adolfo A Ferrando; Fiscal Year: 2012
    The role of AKT signaling in NOTCH1-induced leukemias Aberrant activation of NOTCH signaling due to the presence of activating mutations in the NOTCH1 receptor play a critical role in the pathogenesis of in more than 50% human T-cell ..
  37. A Novel Modulator of Notch in Acute Lymphoblastic Leukemia
    Chengyu Liang; Fiscal Year: 2012
    ..that approximately 60% of cases of pediatric T-cell ALL (T- ALL) are marked with aberrant activation of the Notch1 receptor...
  38. Kunlin Jin; Fiscal Year: 2014
    ..Recent evidence shows that Notch1 signaling is conserved in the regulation of adult neurogenesis...
  39. Notch Effects on Hematopoietic Repopulating Cells
    Irwin Bernstein; Fiscal Year: 2010
    ..is inhibited when these cells are induced to overexpress the constitutively active cytoplasmic domain of Notch1 or when they are exposed to exogenously presented Notch ligand forms...
  40. Chulan Kwon; Fiscal Year: 2016
    ..I demonstrated that Notch1-deficient CPCs expand dramatically with increased proliferation, similar to the phenotype of CPCs stimulated with ..
  41. ALEXIS CARULLI; Fiscal Year: 2014
    ..My preliminary data suggests that the Olfm4 response is Notch1(N1)- specific, suggesting that N1 is the predominate Notch receptor for the ISC...
  42. Quiescent Dclk1+ stem cells in the mouse intestine
    TIMOTHY CRAGIN WANG; Fiscal Year: 2012
    ..radiation injury? Dclk1 progenitors will be activated by conditional deletion of PTEN or activation of IC-Notch1, followed by analysis of the response to radiation injury. (4)...
  43. Iannis Aifantis; Fiscal Year: 2015
    ..CCR7 gene expression is controlled by the activity of the T- ALL oncogene Notch1, the most central oncogene in this disease, and is expressed in human tumors carrying Notch1 activating mutations...
  44. Jonathan P Katz; Fiscal Year: 2016
    ..mediated predominantly by p21Waf1/Cip1, and KLF5 transcriptionally activates the keratinocyte tumor suppressor NOTCH1 when p53 is mutant but not with wild-type p53...
  45. KURT RICHARD WEISS; Fiscal Year: 2016
    ..He has recently discovered that stem cell-associated factors, specifically aldehyde dehydrogenase (ALDH) and Notch1, are differentially expressed in OS cells with different metastatic phenotypes...
  46. Timothy W King; Fiscal Year: 2016
    ..Aim #1: Investigate the role of the Notch family in cutaneous wound healing utilizing chimeric K14 specific Notch1, 2, or 3 knockout mice...
  47. Asgerally T Fazleabas; Fiscal Year: 2016
    ..Our data also demonstrated for the first time that the evolutionary conserved Notch1 protein, which plays a critical role in cell fate decisions, is regulated by CG and progesterone in endometrial ..
  48. CATHERINE JU YING WU; Fiscal Year: 2016
    ..and proliferation of B cells, and on other pathways that we recently identified as critical to CLL (inflammation, Notch1 and Wnt signaling, DNA damage/repair) (Aim 1)...
  49. Notch3 in generation and maintenance of the T lineage.
    Howard T Petrie; Fiscal Year: 2013
    ..While Notch1 (N1) has been shown to play a key role in T lineage specification, it is inadequate to explain the complex process ..
  50. Nihal Ahmad; Fiscal Year: 2016
    ..target of Plk1 in normal melanocytes and melanoma cells;3) To define the mechanism by which Plk1 regulates Notch1 signaling;and 4) To determine the functional and therapeutic significance of Plk1 in vivo in athymic nude mice ..
  51. MARK REID PHILIPS; Fiscal Year: 2016
    ..Because Notch1 deficiency phenocopies Icmt deficiency in the Pdx-1-Cre;KrasLSL/+ model we will also study the requirement for ..
  52. Spatiotemporal Comparison of Aberrant & Ectopic VDJ Recombination Events In Vivo
    PENNY ELLEN SHOCKETT; Fiscal Year: 2010
    ..aberrant RAG-mediated V(D)J events including a TCR D21 RSS reinsertion event on Chromosome 1, and deletions in the Notch1 oncogene and Rit1/Bcl11b tumor suppressor gene, all observed recently with measurable frequencies by direct PCR in ..
  53. Jun Xu; Fiscal Year: 2015
    ..the causal role of Notch 1/2 in HM M1 activation and the genesis of synergistic SH by alcohol and obesity by using Notch1/2flox/flox:Mx1-Cre chimeric mice...
  54. Robert S Haltiwanger; Fiscal Year: 2016
    ..Notch signaling assays to evaluate the importance of individual O-fucose and O-glucose modification sites in mouse Notch1, we identified two functional regions, the ligand-binding domain (EGF11-12) and the Abruptex region (EGF24-29), ..
  55. Notch1-FoxO1 interaction in regulation of hepatic gluconeogenesis
    UTPAL BHAGIRATH PAJVANI; Fiscal Year: 2010
    ..Through genetic manipulation ofthe Notch pathway in mice, we hope to provide evidence that inhibition of Notch signaling in liver can lead to improved glycemic control. ..
  56. Victor E Velculescu; Fiscal Year: 2016
    ..and breast cancers, ARID1A in ovarian clear cell carcinoma, chromatin remodeling genes in medulloblastoma, and NOTCH1 in head and neck cancers...
  57. COURTNEY JO FLEENOR; Fiscal Year: 2014
    ..cultures, indicate that IR exposure causes stable defects in HSC maintenance that can be reversed by activation of Notch1 signaling. The goal of this research proposal is two-fold. 1...
  58. Function of intramembrane aspartic protease
    Evgeny I Rogaev; Fiscal Year: 2012
    ..PSs are required for Notch1 receptor-mediated signaling in early development...
  59. Simon C Body; Fiscal Year: 2016
    ..In a few families, highly-penetrant dominant mutations of NOTCH1 have been associated with BAV. Additional susceptibility loci have also been identified but not replicated...
  60. Ernesto Canalis; Fiscal Year: 2016
    ..mouse lines over expressing Notch or HES-1 in the bone environment, and mice carrying conditional deletions of notch1 and 2 or hes-1...
  61. Role of RORa in Epidermal Differentiation Control
    YANG SUI BROOKS; Fiscal Year: 2012
    ..Moreover, there are several ROR1 binding elements present in the promoter region of Notch1 gene, which is a direct determinant of keratinocyte entry into differentiation, and increased ROR1 expression ..
  62. Raphael Kopan; Fiscal Year: 2016
    ..We have shown that targeting Notch1 specifically will result in vascular tumors in addition to increasing cancer rates in the skin;if this will occur ..
  63. Molecular Targets in T Lineage Leukemia
    Monique Dail; Fiscal Year: 2012
    ..T-ALL patients frequently have genetic alterations that activate the Ras/PI3K/Akt pathway and Notch1, thus testing inhibitors of these pathways is a high priority...
  64. ENDOTHELIUM REGULATION OF STEM CELL HOMING/PROLIFERATION
    Shahin Rafii; Fiscal Year: 2000
    ..In this regard, we plan to study the role of these ligand pairs including DLL1/Notch1, by using blocking monoclonal antibodies to either ligand pair in blinding, and transmigration studies as well as ..
  65. Molecular Biology of Cardiac Valvuloseptal Morphogenesis
    DAVID GEENAN; Fiscal Year: 2006
    ..of the Notch signaling pathway in Hey2 mutant animals, as well as the expression of Hey2 in animals lacking Jag1, Notch1, or Notch2...
  66. Anaylsis of the spatial control of cytokinesis in plants
    Laurie Smith; Fiscal Year: 2005
    ..During the previous grant period, we cloned the Tangled1 (Tan1) gene of maize and showed that it is required for proper orientation of cytoskeletal arrays involved in plant cell ..