norepinephrine transporter

Summary

Gene Symbol: norepinephrine transporter
Description: solute carrier family 6 member 2
Alias: NAT1, NET, NET1, SLC6A5, sodium-dependent noradrenaline transporter, neurotransmitter transporter, norepinephrine transporter, solute carrier family 6 (neurotransmitter transporter), member 2, solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2, solute carrier family 6 member 5
Species: human
Products:     norepinephrine transporter

Top Publications

  1. Barr C, Kroft J, Feng Y, Wigg K, Roberts W, Malone M, et al. The norepinephrine transporter gene and attention-deficit hyperactivity disorder. Am J Med Genet. 2002;114:255-9 pubmed
    ..This study tested the gene for the norepinephrine transporter (NET1) as a susceptibility factor in ADHD using three polymorphisms located in exon 9, intron 9, and ..
  2. Mata S, Urbina M, Manzano E, Ortiz T, Lima L. Noradrenaline transporter and its turnover rate are decreased in blood lymphocytes of patients with major depression. J Neuroimmunol. 2005;170:134-40 pubmed
  3. Porzgen P, Bonisch H, Bruss M. Molecular cloning and organization of the coding region of the human norepinephrine transporter gene. Biochem Biophys Res Commun. 1995;215:1145-50 pubmed
    ..The organization of the gene is highly homologous to other known neurotransmitter transporter genes...
  4. Kim B, Kim J, Hong S, Cho S, Shin M, Yoo H. Possible association of norepinephrine transporter -3081(A/T) polymorphism with methylphenidate response in attention deficit hyperactivity disorder. Behav Brain Funct. 2010;6:57 pubmed publisher
    ..Methylphenidate (MPH) has been shown to block the norepinephrine transporter (NET), and genetic investigations have demonstrated that the norepinephrine transporter gene (SLC6A2) is ..
  5. McEvoy B, Hawi Z, Fitzgerald M, Gill M. No evidence of linkage or association between the norepinephrine transporter (NET) gene polymorphisms and ADHD in the Irish population. Am J Med Genet. 2002;114:665-6 pubmed
  6. Kooij J, Boonstra A, Vermeulen S, Heister A, Burger H, Buitelaar J, et al. Response to methylphenidate in adults with ADHD is associated with a polymorphism in SLC6A3 (DAT1). Am J Med Genet B Neuropsychiatr Genet. 2008;147B:201-8 pubmed
    ..conditions, and polymorphisms in the genes encoding the dopamine transporter, SLC6A3 (DAT1), the norepinephrine transporter, SLC6A2 (NET), and the dopamine receptor D4, DRD4...
  7. Kim C, Hahn M, Joung Y, Anderson S, Steele A, Mazei Robinson M, et al. A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder. Proc Natl Acad Sci U S A. 2006;103:19164-9 pubmed
    The norepinephrine transporter critically regulates both neurotransmission and homeostasis of norepinephrine in the nervous system...
  8. Inoue K, Itoh K, Yoshida K, Shimizu T, Suzuki T. Positive association between T-182C polymorphism in the norepinephrine transporter gene and susceptibility to major depressive disorder in a japanese population. Neuropsychobiology. 2004;50:301-4 pubmed
    ..system appears to have a major impact on the symptomatology in major depressive disorder and the human norepinephrine transporter (NET) gene is one of the key candidates for genetic studies in major depressive disorder...
  9. Renner T, Nguyen T, Romanos M, Walitza S, Roser C, Reif A, et al. No evidence for association between a functional promoter variant of the Norepinephrine Transporter gene SLC6A2 and ADHD in a family-based sample. Atten Defic Hyperact Disord. 2011;3:285-9 pubmed publisher
    ..The norepinephrine transporter facilitates the reuptake of norepinephrine and dopamine in the prefrontal cortex and represents the main ..

More Information

Publications87

  1. Joung Y, Kim C, Moon J, Jang W, Yang J, Shin D, et al. Association studies of -3081(A/T) polymorphism of norepinephrine transporter gene with attention deficit/hyperactivity disorder in Korean population. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:691-694 pubmed publisher
    ..It is revealed that the norepinephrine transporter gene (SLC6A2) is a possible candidate gene directly related to ADHD...
  2. Ramoz N, Boni C, Downing A, Close S, Peters S, Prokop A, et al. A haplotype of the norepinephrine transporter (Net) gene Slc6a2 is associated with clinical response to atomoxetine in attention-deficit hyperactivity disorder (ADHD). Neuropsychopharmacology. 2009;34:2135-42 pubmed publisher
    Atomoxetine is a specific inhibitor of the norepinephrine transporter (NET) that has demonstrated efficacy in the treatment of children with attention-deficit hyperactivity disorder (ADHD)...
  3. Mick E, Neale B, Middleton F, McGough J, Faraone S. Genome-wide association study of response to methylphenidate in 187 children with attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1412-8 pubmed publisher
    ..Among the 102 available SNPs covering previously studied candidate genes, two SNPs within the norepinephrine transporter gene (NET, SLC6A2) were significant at P < or = 1 x 10(-2)...
  4. Distelmaier F, Wiedemann P, Bruss M, Bonisch H. Functional importance of the C-terminus of the human norepinephrine transporter. J Neurochem. 2004;91:537-46 pubmed
    Three C-terminal variants of the human norepinephrine transporter (hNET) are known: the wild-type hNET in which exon 14 encodes the last seven amino acids and two variants with either three or 18 amino acids encoded by an alternatively ..
  5. Bobb A, Addington A, Sidransky E, Gornick M, Lerch J, Greenstein D, et al. Support for association between ADHD and two candidate genes: NET1 and DRD1. Am J Med Genet B Neuropsychiatr Genet. 2005;134B:67-72 pubmed
    ..Multiple candidate genes have been studied in ADHD, including the norepinephrine transporter (NET1) and dopamine D1 receptor (DRD1)...
  6. Sogawa C, Kumagai K, Sogawa N, Morita K, Dohi T, Kitayama S. C-terminal region regulates the functional expression of human noradrenaline transporter splice variants. Biochem J. 2007;401:185-95 pubmed
    The NET [noradrenaline (norepinephrine) transporter], an Na+/Cl--dependent neurotransmitter transporter, has several isoforms produced by alternative splicing in the C-terminal region, each differing in expression and function...
  7. Ryu S, Lee S, Lee H, Cha J, Ham B, Han C, et al. Association between norepinephrine transporter gene polymorphism and major depression. Neuropsychobiology. 2004;49:174-7 pubmed
    ..It is suggested that the dysfunction of the norepinephrine transporter (NET) may be related to major depression...
  8. Hahn M, Robertson D, Blakely R. A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters. J Neurosci. 2003;23:4470-8 pubmed
    The norepinephrine transporter (NET) mediates reuptake of norepinephrine released from neurons, and, as such, it is an important regulator of noradrenergic neurotransmission...
  9. Cho S, Kim J, Kim B, Hwang J, Park M, Kim S, et al. No evidence of an association between norepinephrine transporter gene polymorphisms and attention deficit hyperactivity disorder: a family-based and case-control association study in a Korean sample. Neuropsychobiology. 2008;57:131-8 pubmed publisher
    ..Previous studies have demonstrated that the norepinephrine transporter gene (SLC6A2) is associated with ADHD...
  10. Retz W, Rosler M, Kissling C, Wiemann S, Hünnerkopf R, Coogan A, et al. Norepinephrine transporter and catecholamine-O-methyltransferase gene variants and attention-deficit/hyperactivity disorder symptoms in adults. J Neural Transm (Vienna). 2008;115:323-9 pubmed
    ..version of the WRAADDS, WRI) with haplotypes of the catechol-O-methyltransferase (COMT) and the norepinephrine transporter (SLC6A2) genes...
  11. Kim C, Waldman I, Blakely R, Kim K. Functional gene variation in the human norepinephrine transporter: association with attention deficit hyperactivity disorder. Ann N Y Acad Sci. 2008;1129:256-60 pubmed publisher
    The norepinephrine (NE) transporter (NET) is responsible for the re-uptake of NE into presynaptic nerve terminals, thus critically regulating noradrenergic signaling and homeostasis...
  12. Song D, Jhung K, Song J, Cheon K. The 1287 G/A polymorphism of the norepinephrine transporter gene (NET) is involved in commission errors in Korean children with attention deficit hyperactivity disorder. Behav Brain Funct. 2011;7:12 pubmed publisher
    Previous evidence supports the role of noradrenergic systems in ADHD, and norepinephrine transporter (NET) is critical in regulating the noradrenergic system...
  13. Lee S, Kim S, Lee M, Yook K, Greenhill L, Fradin K, et al. Lack of association between response of OROS-methylphenidate and norepinephrine transporter (SLC6A2) polymorphism in Korean ADHD. Psychiatry Res. 2011;186:338-44 pubmed publisher
    ..between the five common polymorphisms (rs2242446, rs5568, rs5569, rs998424, and rs1616905) in the norepinephrine transporter (NET) gene and the OROS-methylphenidate response in a medication-naïve Korean attention-deficit ..
  14. Kollins S, Anastopoulos A, Lachiewicz A, Fitzgerald D, Morrissey Kane E, Garrett M, et al. SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1580-8 pubmed publisher
    ..errors and SNPs in the DRD2 gene (rs2075654, rs1079596), and between reaction time variability and a SNP in the NET gene (rs3785155)...
  15. Yoshida K, Takahashi H, Higuchi H, Kamata M, Ito K, Sato K, et al. Prediction of antidepressant response to milnacipran by norepinephrine transporter gene polymorphisms. Am J Psychiatry. 2004;161:1575-80 pubmed
    ..The purpose of the present study was to determine whether norepinephrine transporter gene (NET) and serotonin transporter gene (5-HTT) polymorphisms are associated with the antidepressant ..
  16. Yang L, Wang Y, Li J, Faraone S. Association of norepinephrine transporter gene with methylphenidate response. J Am Acad Child Adolesc Psychiatry. 2004;43:1154-8 pubmed
    This study aimed to explore the association between alleles of the norepinephrine transporter gene and the methylphenidate response...
  17. McGough J, McCracken J, Loo S, Manganiello M, Leung M, Tietjens J, et al. A candidate gene analysis of methylphenidate response in attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2009;48:1155-64 pubmed publisher
  18. Bauman P, Blakely R. Determinants within the C-terminus of the human norepinephrine transporter dictate transporter trafficking, stability, and activity. Arch Biochem Biophys. 2002;404:80-91 pubmed
    The function of the human norepinephrine transporter (hNET) depends on its presence at the cell surface...
  19. Kocabas A, Rudnick G, Kilic F. Functional consequences of homo- but not hetero-oligomerization between transporters for the biogenic amine neurotransmitters. J Neurochem. 2003;85:1513-20 pubmed
    Before this study, the human norepinephrine transporter (hNET) was the only member of the biogenic amine neurotransmitter transporter family that had not been demonstrated to be a functional homo-oligomer...
  20. Kim J, Biederman J, McGrath C, Doyle A, Mick E, Fagerness J, et al. Further evidence of association between two NET single-nucleotide polymorphisms with ADHD. Mol Psychiatry. 2008;13:624-30 pubmed
    The norepinephrine transporter (NET) gene is an attractive candidate gene for attention-deficit hyperactivity disorder (ADHD)...
  21. Bruss M, Kunz J, Lingen B, Bonisch H. Chromosomal mapping of the human gene for the tricyclic antidepressant-sensitive noradrenaline transporter. Hum Genet. 1993;91:278-80 pubmed
    ..2. In addition, evidence is presented for an intron-exon structure of the gene. ..
  22. Torres G, Yao W, Mohn A, Quan H, Kim K, Levey A, et al. Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. Neuron. 2001;30:121-34 pubmed
    ..These findings indicate a role for PDZ-mediated protein interactions in the localization, expression, and function of monoamine transporters. ..
  23. Porzgen P, Bonisch H, Hammermann R, Bruss M. The human noradrenaline transporter gene contains multiple polyadenylation sites and two alternatively spliced C-terminal exons. Biochim Biophys Acta. 1998;1398:365-70 pubmed
  24. Pacholczyk T, Blakely R, Amara S. Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature. 1991;350:350-4 pubmed
    ..identity with the Na+/gamma-aminobutyric acid transporter, thus identifying a new gene family for neurotransmitter transporter proteins...
  25. Takano A, Varrone A, Gulyas B, Karlsson P, Tauscher J, Halldin C. Mapping of the norepinephrine transporter in the human brain using PET with (S,S)-[18F]FMeNER-D2. Neuroimage. 2008;42:474-82 pubmed publisher
    We have evaluated the detailed mapping of the norepinephrine transporter (NET) in the human brain with (S,S)-[(18)F]FMeNER-D(2) using a template method and the generation of functional ROIs based on the PET information...
  26. Zhang Y, Xia P, Zhang W, Yan M, Xiong X, Yu W, et al. Short interfering RNA targeting Net1 reduces the angiogenesis and tumor growth of in vivo cervical squamous cell carcinoma through VEGF down-regulation. Hum Pathol. 2017;65:113-122 pubmed publisher
    b>Net1, a guanine nucleotide exchange factor, is implicated in cancer cell invasion through activation of RhoA. However, there is still no report on the association between Net1 and cancer angiogenesis...
  27. Browne C, Fletcher P, Zeeb F. Responding for a conditioned reinforcer or unconditioned sensory reinforcer in mice: interactions with environmental enrichment, social isolation, and monoamine reuptake inhibitors. Psychopharmacology (Berl). 2016;233:983-93 pubmed publisher
    ..Administration of citalopram, a serotonin transporter blocker, or atomoxetine, a norepinephrine transporter blocker, decreased responding for the CRf and USRf in all groups...
  28. Gizer I, Ficks C, Waldman I. Candidate gene studies of ADHD: a meta-analytic review. Hum Genet. 2009;126:51-90 pubmed publisher
    ..g., ADHD subtype diagnoses, gender, exposure to environmental risk factors). We conclude with a discussion of these findings in relation to emerging themes relevant to future studies of the genetics of ADHD. ..
  29. Imai T, Tanaka K, Yonemitsu T, Yakushiji Y, Ohura K. Elucidation of the Intestinal Absorption of para-Aminobenzoic Acid, a Marker for Dietary Intake. J Pharm Sci. 2017;106:2881-2888 pubmed publisher
    ..N-Acetyl-PABA is formed by human arylamine N-acetyltransferase 1 (NAT1) in liver and intestine...
  30. Yang L, Qian Q, Liu L, Li H, Faraone S, Wang Y. Adrenergic neurotransmitter system transporter and receptor genes associated with atomoxetine response in attention-deficit hyperactivity disorder children. J Neural Transm (Vienna). 2013;120:1127-33 pubmed publisher
    Atomoxetine, a selective inhibitor of the norepinephrine transporter, exerts its therapeutic effect for attention-deficit hyperactivity disorder (ADHD) by increasing the concentration of synaptic norepinephrine...
  31. Ham B, Choi M, Lee H, Kang R, Lee M. Reward dependence is related to norepinephrine transporter T-182C gene polymorphism in a Korean population. Psychiatr Genet. 2005;15:145-7 pubmed
    ..study was to investigate a relationship between personality traits and the T-182C polymorphism in the norepinephrine transporter gene...
  32. Zhang H, Huang R, Cheung N, Guo H, Zanzonico P, Thaler H, et al. Imaging the norepinephrine transporter in neuroblastoma: a comparison of [18F]-MFBG and 123I-MIBG. Clin Cancer Res. 2014;20:2182-91 pubmed publisher
    The norepinephrine transporter (NET) is a critical regulator of catecholamine uptake in normal physiology and is expressed in neuroendocrine tumors like neuroblastoma...
  33. Sugiyama H, Takahashi K, Yamamoto T, Iwasaki M, Narita M, Nakamura M, et al. Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells. Proc Natl Acad Sci U S A. 2017;114:340-345 pubmed publisher
    Novel APOBEC1 target 1 (Nat1) (also known as "p97," "Dap5," and "Eif4g2") is a ubiquitously expressed cytoplasmic protein that is homologous to the C-terminal two thirds of eukaryotic translation initiation factor 4G (Eif4g1)...
  34. Al Shaqha W, Alkharfy K, Al Daghri N, Mohammed A. N-acetyltransferase 1 and 2 polymorphisms and risk of diabetes mellitus type 2 in a Saudi population. Ann Saudi Med. 2015;35:214-21 pubmed publisher
    ..Therefore, the main objective of this study was to identify whether the genetic polymorphisms of NAT1 and NAT2 play a role in susceptibility to T2DM in the Saudi population...
  35. Moriguchi S, Kimura Y, Ichise M, Arakawa R, Takano H, Seki C, et al. PET Quantification of the Norepinephrine Transporter in Human Brain with (S,S)-18F-FMeNER-D2. J Nucl Med. 2017;58:1140-1145 pubmed publisher
    b>Norepinephrine transporter (NET) in the brain plays important roles in human cognition and the pathophysiology of psychiatric disorders...
  36. Rippel C, Kobets A, Yoon D, Williams P, Shugart Y, Bridges D, et al. Norepinephrine transporter polymorphisms in Tourette syndrome with and without attention deficit hyperactivity disorder: no evidence for significant association. Psychiatr Genet. 2006;16:179-80 pubmed
    ..hyperactivity disorder were evaluated for association with two single nucleotide polymorphisms of the norepinephrine transporter gene (SLC6A2); a T-182C single nucleotide polymorphism located in the 5' flanking promoter region and a ..
  37. Xu Y, Li F, Huang X, Sun N, Zhang F, Liu P, et al. The norepinephrine transporter gene modulates the relationship between urban/rural residency and major depressive disorder in a Chinese population. Psychiatry Res. 2009;168:213-7 pubmed publisher
    The norepinephrine transporter (NET), which is involved in the neurotransmission of norepinephrine (NE), may play an important role in the development of major depressive disorder (MDD)...
  38. Sigurdardottir H, Kranz G, Rami Mark C, James G, Vanicek T, Gryglewski G, et al. Effects of norepinephrine transporter gene variants on NET binding in ADHD and healthy controls investigated by PET. Hum Brain Mapp. 2016;37:884-95 pubmed publisher
    ..The norepinephrine transporter (NET) is a key target for ADHD treatment and the NET gene has been of high interest as a possible ..
  39. Hahn M, Blackford J, Haman K, Mazei Robison M, English B, Prasad H, et al. Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression. Genes Brain Behav. 2008;7:487-95 pubmed
    ..MPT analyses show significant associations of the norepinephrine transporter (NET, SLC6A2) -182 T/C (rs2242446) with recurrent depression [odds ratio, OR = 4.15 (1.91-9...
  40. Kim H, Camilleri M, Carlson P, Cremonini F, Ferber I, Stephens D, et al. Association of distinct alpha(2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders. Gut. 2004;53:829-37 pubmed
    ..Our aims were: (1) to compare the prevalence of polymorphisms of alpha 2 (alpha(2)) adrenoceptors, norepinephrine transporter, and serotonin transporter protein (soluble carrier protein member 4 (SLC6A4)) promoter in patients with ..
  41. Alba Delgado C, Cebada Aleu A, Mico J, Berrocoso E. Comorbid anxiety-like behavior and locus coeruleus impairment in diabetic peripheral neuropathy: A comparative study with the chronic constriction injury model. Prog Neuropsychopharmacol Biol Psychiatry. 2016;71:45-56 pubmed publisher
    ..However, the nociceptive sensitivity time-course, as well as the LC functions, showed distinct features compared to the CCI model, indicating that specific neuroplastic mechanisms are at play in every model. ..
  42. Webster S, O Rourke K, Fletcher C, Pimlott S, Sutherland A, Lee A. Rapid Iododeboronation with and without Gold Catalysis: Application to Radiolabelling of Arenes. Chemistry. 2017;: pubmed publisher
    ..This has been exemplified with an effective synthesis of radiolabelled meta-[125I]iodobenzylguanidine, a radiopharmaceutical used for the imaging and therapy of human norepinephrine transporter-expressing tumours.
  43. Sloan K, Marquez H, Li J, Cao Y, Hinds A, O Hara C, et al. Increased PEA3/E1AF and decreased Net/Elk-3, both ETS proteins, characterize human NSCLC progression and regulate caveolin-1 transcription in Calu-1 and NCI-H23 NSCLC cell lines. Carcinogenesis. 2009;30:1433-42 pubmed publisher
    ..Conversely, Net, a known ETS repressor, is expressed at high levels in the nucleus of well-differentiated primary tumor cells...
  44. Pandit Taskar N, Modak S. Norepinephrine Transporter as a Target for Imaging and Therapy. J Nucl Med. 2017;58:39S-53S pubmed publisher
    The norepinephrine transporter (NET) is essential for norepinephrine uptake at the synaptic terminals and adrenal chromaffin cells. In neuroendocrine tumors, NET can be targeted for imaging as well as therapy...
  45. Wu C, Wu H, Tsai Y, Huang Y, Tsai H. Use of antidepressants and risk of hospitalization for acute myocardial infarction: A nationwide case-crossover study. J Psychiatr Res. 2017;94:7-14 pubmed publisher
    ..88-1.24). Likewise, neither the class, dose, nor the binding affinity of serotonin transporter or norepinephrine transporter was associated with AMI risks, and there was no modifying effect of age, gender, or comorbid medical ..
  46. Al Dera H, Brock J. Changes in sympathetic neurovascular function following spinal cord injury. Auton Neurosci. 2018;209:25-36 pubmed publisher
  47. Werner R, Rischpler C, Onthank D, Lapa C, Robinson S, Samnick S, et al. Retention Kinetics of the 18F-Labeled Sympathetic Nerve PET Tracer LMI1195: Comparison with 11C-Hydroxyephedrine and 123I-MIBG. J Nucl Med. 2015;56:1429-33 pubmed publisher
    ..99 ± 0.12 (desipramine chase) vs. 2.05 ± 0.16 (controls), not statistically significant). In vivo norepinephrine transporter (NET) blockade with desipramine confirmed specific neural uptake of (18)F-LMI1195, (11)C-..
  48. Gonia S, Berman J, Gale C. Generation of Fluorescent Protein Fusions in Candida Species. J Vis Exp. 2017;: pubmed publisher
    ..Plasmids containing the nourseothricin resistance transformation marker gene (NAT1) along with sequences for either green, yellow, or cherry FPs (GFP, YFP, mCherry) are used along with primers that ..
  49. Hohoff C, Domschke K, Schwarte K, Spellmeyer G, Vogele C, Hetzel G, et al. Sympathetic activity relates to adenosine A(2A) receptor gene variation in blood-injury phobia. J Neural Transm (Vienna). 2009;116:659-62 pubmed publisher
    ..in the candidate genes adenosine A(2A) receptor (A(2A)R), catechol-O-methyl-transferase (COMT), and norepinephrine transporter (NET) has been suggested to influence vulnerability to panic disorder...
  50. Vizeli P, Meyer zu Schwabedissen H, Liechti M. No major role of norepinephrine transporter gene variations in the cardiostimulant effects of MDMA. Eur J Clin Pharmacol. 2018;74:275-283 pubmed publisher
    ..MDMA produces cardiovascular and subjective stimulant effects that were shown to partially depend on the norepinephrine transporter (NET)-mediated release of norepinephrine and stimulation of α1-adrenergic receptors...
  51. Freissmuth M, Stockner T, Sucic S. SLC6 Transporter Folding Diseases and Pharmacochaperoning. Handb Exp Pharmacol. 2018;245:249-270 pubmed publisher
    ..mutations in the transporters for dopamine (DAT, SLC6A3), for creatine (CT1, SLC6A8), and for glycine (GlyT2, SLC6A5), which result in infantile dystonia, mental retardation, and hyperekplexia, respectively...
  52. Wang P, Shehu A, Lu J, Joshi R, Venkataramanan R, Sugamori K, et al. Deficiency of N-acetyltransferase increases the interactions of isoniazid with endobiotics in mouse liver. Biochem Pharmacol. 2017;145:218-225 pubmed publisher
    ..The current study used Nat1/2(-/-) mice to mimic NAT slow metabolizers and to investigate INH metabolism in the liver...
  53. Uher R, Huezo Diaz P, Perroud N, Smith R, Rietschel M, Mors O, et al. Genetic predictors of response to antidepressants in the GENDEP project. Pharmacogenomics J. 2009;9:225-33 pubmed publisher
    ..1% of variance (P=0.0016). Variants in the norepinephrine transporter gene (SLC6A2) predicted response to nortriptyline, and variants in the glucocorticoid receptor gene (..
  54. Proft F, Kopf J, Olmes D, Hempel S, Schmidt B, Riederer P, et al. SLC6A2 and SLC6A4 variants interact with venlafaxine serum concentrations to influence therapy outcome. Pharmacopsychiatry. 2014;47:245-50 pubmed publisher
    ..The observed association is consistent with findings of some previous studies, whereas others showed differing results highlighting the need for further investigations. ..
  55. Rami Mark C, Eberherr N, Berroterán Infante N, Vanicek T, Nics L, Lanzenberger R, et al. [(18)F]FMeNER-D2: A systematic in vitro analysis of radio-metabolism. Nucl Med Biol. 2016;43:490-5 pubmed publisher
    The norepinephrine transporter (NET) presents an important target for therapy and diagnosis of ADHD and other neurodegenerative and psychiatric diseases...
  56. Paczkowski F, Bryan Lluka L. Tyrosine residue 271 of the norepinephrine transporter is an important determinant of its pharmacology. Brain Res Mol Brain Res. 2001;97:32-42 pubmed
    The aim was to examine the functional importance in the norepinephrine transporter (NET) of (i) the phenylalanine residue at position 531 in transmembrane domain (TMD) 11 by mutating it to tyrosine in the rat (rF531Y) and human (hF531Y) ..
  57. Kautto M, Kampman O, Mononen N, Lehtimäki T, Haraldsson S, Koivisto P, et al. Serotonin transporter (5-HTTLPR) and norepinephrine transporter (NET) gene polymorphisms: susceptibility and treatment response of electroconvulsive therapy in treatment resistant depression. Neurosci Lett. 2015;590:116-20 pubmed publisher
    Serotonin transporter (5-HTTLPR) and norepinephrine transporter (NET182C) polymorphisms are associated with susceptibility and treatment response in major depressive disorder (MDD)...
  58. Zhang H, Smith G, Liu X, Holden J. Association of MAOA, 5-HTT, and NET promoter polymorphisms with gene expression and protein activity in human placentas. Physiol Genomics. 2010;42:85-92 pubmed publisher
    Monoamine oxidase A (MAOA) and the transporters for serotonin (5-HTT) and norepinephrine (NET) may play important roles in regulating maternal monoamine neurotransmitters transferred across the placenta to the fetus...
  59. Zhou Y, Su H, Song J, Guo L, Sun Y. Association between norepinephrine transporter T-182C polymorphism and major depressive disorder: a meta-analysis. Neurosci Lett. 2014;561:64-8 pubmed publisher
    The human norepinephrine transporter (NET) gene is one of the key candidates for genetic studies in major depressive disorder (MDD)...
  60. Tang L, Morris J, Wan J, Moore C, Fujita Y, Gillaspie S, et al. Competition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide. Nucleic Acids Res. 2017;45:11941-11953 pubmed publisher
    ..Consistently, eIF5 increases, whereas 5MP decreases translation of NAT1/EIF4G2/DAP5, whose sole start codon is GUG...
  61. Cauley A, Wilson J. Functionalized lignin biomaterials for enhancing optical properties and cellular interactions of dyes. Biomater Sci. 2017;5:2114-2121 pubmed publisher
    ..Lignin functionalized with short chain carboxylic acids interacts with ligands directed at the norepinephrine transporter (NET), suggesting applications in sequestration of neuroactive compounds.
  62. Xu X, Knight J, Brookes K, Mill J, Sham P, Craig I, et al. DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: no evidence for association. Am J Med Genet B Neuropsychiatr Genet. 2005;134B:115-8 pubmed
    ..This study set out to investigate whether common polymorphisms within the norepinephrine transporter gene (NET1) are associated with DSM-IV ADHD combined subtype, using a sample that has previously shown ..
  63. Bayles R, Harikrishnan K, Lambert E, Baker E, Agrotis A, Guo L, et al. Epigenetic modification of the norepinephrine transporter gene in postural tachycardia syndrome. Arterioscler Thromb Vasc Biol. 2012;32:1910-6 pubmed publisher
    ..Previous research has implicated dysfunction of the norepinephrine transporter. A coding mutation in the norepinephrine transporter gene (SLC6A2) sequence has been reported in 1 ..
  64. Paczkowski F, Bonisch H, Bryan Lluka L. Pharmacological properties of the naturally occurring Ala(457)Pro variant of the human norepinephrine transporter. Pharmacogenetics. 2002;12:165-73 pubmed
    Recently, another research group has reported an almost complete loss of function of the human norepinephrine transporter (hNET) in patients who had orthostatic intolerance and who were heterozygous for a guanine to cytosine exchange, ..
  65. Urwin R, Bennetts B, Wilcken B, Lampropoulos B, Beumont P, Clarke S, et al. Anorexia nervosa (restrictive subtype) is associated with a polymorphism in the novel norepinephrine transporter gene promoter polymorphic region. Mol Psychiatry. 2002;7:652-7 pubmed
    ..Since this may reflect altered reuptake by the norepinephrine transporter (NET), we hypothesised that the NET gene was involved in the genetic component of AN...
  66. Park S, Park J, Cho S, Kim B, Shin M, Kim J, et al. No association of the norepinephrine transporter gene (SLC6A2) and cognitive and behavioural phenotypes of patients with autism spectrum disorder. Eur Arch Psychiatry Clin Neurosci. 2014;264:507-15 pubmed publisher
    We examined the association between the norepinephrine transporter (SLC6A2) gene and autism spectrum disorder (ASD) in a Korean population. In addition, we investigated which phenotypes of ASD are best attributed to the genotype of SLC6A2...
  67. Müller P, Asher N, Heled M, Cohen S, Risch A, Rund D. Polymorphisms in transporter and phase II metabolism genes as potential modifiers of the predisposition to and treatment outcome of de novo acute myeloid leukemia in Israeli ethnic groups. Leuk Res. 2008;32:919-29 pubmed publisher
    ..We analyzed: ABCC3 (MRP3) C-211T; ABCG2 (BCRP) C421A; CNT1 (SLC28A1) G565A and NAT1, NAT2, and GSTT1 and GSTM1 null alleles for influence on predisposition, as well as treatment response and survival...
  68. Okkerse P, Hay J, Sitsen E, Dahan A, Klaassen E, Houghton W, et al. Pharmacokinetics and pharmacodynamics of intrathecally administered Xen2174, a synthetic conopeptide with norepinephrine reuptake inhibitor and analgesic properties. Br J Clin Pharmacol. 2017;83:751-763 pubmed publisher
    Xen2174 is a synthetic 13-amino acid peptide that binds specifically to the norepinephrine transporter, which results in inhibition of norepinephrine uptake...
  69. Chang C, Lu R, Ma K, Chang H, Chen C, Huang C, et al. Association study of the norepinephrine transporter gene polymorphisms and bipolar disorder in Han Chinese population. World J Biol Psychiatry. 2007;8:188-95 pubmed
    Many studies have indicated that the norepinephrine transporter (NET) may play an important role in the mechanisms underlying affective disorders...
  70. Tsai S, Wang Y, Hong C. Norepinephrine transporter and alpha(2c) adrenoceptor allelic variants and personality factors. Am J Med Genet. 2002;114:649-51 pubmed
    ..investigation, 190 normal young Han Chinese were examined, with genetic polymorphisms determined for the norepinephrine transporter (1287G/A) and the alpha(2c)-adrenoceptor (Del322-325) to test the association with TPQ personality ..
  71. Sogawa C, Mitsuhata C, Kumagai Morioka K, Sogawa N, Ohyama K, Morita K, et al. Expression and function of variants of human catecholamine transporters lacking the fifth transmembrane region encoded by exon 6. PLoS ONE. 2010;5:e11945 pubmed publisher
    The transporters for dopamine (DAT) and norepinephrine (NET) are members of the Na+- and Cl--dependent neurotransmitter transporter family SLC6...
  72. Schlessinger A, Geier E, Fan H, Irwin J, Shoichet B, Giacomini K, et al. Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET. Proc Natl Acad Sci U S A. 2011;108:15810-5 pubmed publisher
    The norepinephrine transporter (NET) transports norepinephrine from the synapse into presynaptic neurons, where norepinephrine regulates signaling pathways associated with cardiovascular effects and behavioral traits via binding to ..
  73. Gelernter J, Kruger S, Pakstis A, Pacholczyk T, Sparkes R, Kidd K, et al. Assignment of the norepinephrine transporter protein (NET1) locus to chromosome 16. Genomics. 1993;18:690-2 pubmed
    The norepinephrine transporter protein (NET) is the presynaptic reuptake site for norepinephrine and a site of action for several drugs with CNS effects, some of which are therapeutically useful and some of which are drugs of abuse...
  74. Baffa A, Hohoff C, Baune B, Muller Tidow C, Tidow N, Freitag C, et al. Norepinephrine and serotonin transporter genes: impact on treatment response in depression. Neuropsychobiology. 2010;62:121-31 pubmed publisher
    The norepinephrine transporter (NET) and serotonin transporter (5-HTT) genes constitute promising candidate genes in major depression...
  75. Whelan R, Conrod P, Poline J, Lourdusamy A, Banaschewski T, Barker G, et al. Adolescent impulsivity phenotypes characterized by distinct brain networks. Nat Neurosci. 2012;15:920-5 pubmed publisher
    ..inhibition process (n = 826) and use of illegal substances and associated with genetic variation in a norepinephrine transporter gene (n = 819)...
  76. Feki Tounsi M, Khlifi R, Louati I, Fourati M, Mhiri M, Hamza Chaffai A, et al. Polymorphisms in XRCC1, ERCC2, and ERCC3 DNA repair genes, CYP1A1 xenobiotic metabolism gene, and tobacco are associated with bladder cancer susceptibility in Tunisian population. Environ Sci Pollut Res Int. 2017;24:22476-22484 pubmed publisher
    ..of BC with environmental agents and polymorphisms in XRCC1, ERCC2, and ERCC3 DNA repair genes and CYP1A1, CYP2D6, NAT1, and NAT2 xenobiotic metabolism genes through a hospital-based case-control study in Tunisia...
  77. Lambert E, Eikelis N, Esler M, Dawood T, Schlaich M, Bayles R, et al. Altered sympathetic nervous reactivity and norepinephrine transporter expression in patients with postural tachycardia syndrome. Circ Arrhythm Electrophysiol. 2008;1:103-9 pubmed publisher
    ..suggest abnormal sympathetic nervous system activity and a dysfunction of the norepinephrine (NE) transporter (NET)...
  78. Huang S, Lu R, Ma K, Shy M, Lin W. Norepinephrine transporter polymorphisms T-182C and G1287A are not associated with alcohol dependence and its clinical subgroups. Drug Alcohol Depend. 2008;92:20-6 pubmed
    Several studies have suggested that the norepinephrine transporter (NET) may play an important role in the pathogenesis of alcohol dependence...