Gene Symbol: NOP53
Description: NOP53 ribosome biogenesis factor
Alias: GLTSCR2, PICT-1, PICT1, ribosome biogenesis protein NOP53, glioma tumor suppressor candidate region gene 2 protein, p60, protein interacting with carboxyl terminus 1
Species: human
Products:     NOP53

Top Publications

  1. Okahara F, Itoh K, Nakagawara A, Murakami M, Kanaho Y, Maehama T. Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation. Mol Biol Cell. 2006;17:4888-95 pubmed
    ..Recent study revealed that PICT-1/GLTSCR2 bound to and stabilized PTEN protein in cells, implicating its roles in PTEN-governed PIP(3) signals...
  2. Bruni R, Fineschi B, Ogle W, Roizman B. A novel cellular protein, p60, interacting with both herpes simplex virus 1 regulatory proteins ICP22 and ICP0 is modified in a cell-type-specific manner and Is recruited to the nucleus after infection. J Virol. 1999;73:3810-7 pubmed
    ..We report the identification in the yeast two-hybrid system of a cellular protein designated p60 that interacts with ICP22...
  3. Kim J, Seok K, Kim Y, Bae W, Lee S, Park J. Involvement of GLTSCR2 in the DNA Damage Response. Am J Pathol. 2011;179:1257-64 pubmed publisher
    ..b>GLTSCR2 is a nucleolar protein believed to function as a tumor suppressor, although its exact molecular mechanisms have ..
  4. Lee S, Kim J, Kim Y, Seok K, Kim J, Chang Y, et al. Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses. Cell Death Differ. 2012;19:1613-22 pubmed publisher
    ..In this work, we show that nucleolar protein glioma tumor-suppressor candidate region gene 2 (GLTSCR2) translocates to the nucleoplasm under ribosomal stress, where it interacts with and stabilizes p53 and inhibits ..
  5. Okahara F, Ikawa H, Kanaho Y, Maehama T. Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein. J Biol Chem. 2004;279:45300-3 pubmed
    ..In this study, we have identified a protein, referred to as PICT-1 (protein interacting with carboxyl terminus 1), that binds to the C terminus of PTEN and regulates its phosphorylation and turnover...
  6. Sasaki M, Kawahara K, Nishio M, Mimori K, Kogo R, Hamada K, et al. Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med. 2011;17:944-51 pubmed publisher
    PICT1 (also known as GLTSCR2) is considered a tumor suppressor because it stabilizes phosphatase and tensin homolog (PTEN), but individuals with oligodendrogliomas lacking chromosome 19q13, where PICT1 is located, have better prognoses ..
  7. Kim Y, Cho Y, Kim Y, Kim J, Lee S, Park J. Suppression of putative tumour suppressor gene GLTSCR2 expression in human glioblastomas. J Pathol. 2008;216:218-24 pubmed publisher
    Glioma tumour-suppressor candidate region gene 2 (GLTSCR2/PICT-1) is localized within the well-known 1.4 Mb tumour-suppressive region of chromosome 19q, which is frequently altered in various human tumours, including diffuse gliomas...
  8. Kalt I, Borodianskiy Shteinberg T, Schachor A, Sarid R. GLTSCR2/PICT-1, a putative tumor suppressor gene product, induces the nucleolar targeting of the Kaposi's sarcoma-associated herpesvirus KS-Bcl-2 protein. J Virol. 2010;84:2935-45 pubmed publisher
    ..assays, we identified a novel KS-Bcl-2-interacting protein, referred to as protein interacting with carboxyl terminus 1 (PICT-1), encoded by a candidate tumor suppressor gene, GLTSCR2...
  9. Chen H, Mei L, Zhou L, Zhang X, Guo C, Li J, et al. Moesin-ezrin-radixin-like protein (merlin) mediates protein interacting with the carboxyl terminus-1 (PICT-1)-induced growth inhibition of glioblastoma cells in the nucleus. Int J Biochem Cell Biol. 2011;43:545-55 pubmed publisher
    ..We have identified protein interacting with carboxyl terminus 1 (PICT-1) as a novel merlin-binding partner...

More Information


  1. Smith J, Tachibana I, Pohl U, Lee H, Thanarajasingam U, Portier B, et al. A transcript map of the chromosome 19q-arm glioma tumor suppressor region. Genomics. 2000;64:44-50 pubmed
    ..selection, exon amplification, and genomic sequencing to identify three novel transcripts (EHD2, GLTSCR1, and GLTSCR2) and to map two known genes (SEPW1 and CRX)...
  2. Yim J, Kim Y, Ko J, Cho Y, Kim S, Kim J, et al. The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death. Cell Death Differ. 2007;14:1872-9 pubmed
    Glioma tumor suppressor candidate region gene 2 (GLTSCR2/PICT-1) is localized within the well-known 1.4-Mb tumor suppressive region of chromosome 19q, which is frequently altered in various human tumors, including diffuse gliomas...
  3. Suzuki A, Kogo R, Kawahara K, Sasaki M, Nishio M, Maehama T, et al. A new PICTure of nucleolar stress. Cancer Sci. 2012;103:632-7 pubmed publisher
    ..RPs influence the prognosis of human cancer patients? Our laboratory recently identified the nucleolar protein PICT1 as a novel regulator of nucleolar stress...
  4. Heyne H, Lautenschläger S, NELSON R, Besnier F, Rotival M, Cagan A, et al. Genetic influences on brain gene expression in rats selected for tameness and aggression. Genetics. 2014;198:1277-90 pubmed publisher
    ..rat selection lines, and correlations between gene expression and tameness in F2 animals, we identify the genes Gltscr2, Lgi4, Zfp40, and Slc17a7 as candidate contributors to the strikingly different behavior of the tame and ..
  5. Okamura K, Takayama K, Kawahara K, Harada T, Nishio M, Otsubo K, et al. PICT1 expression is a poor prognostic factor in non-small cell lung cancer. Oncoscience. 2014;1:375-82 pubmed
    b>PICT1 is a key regulator of the MDM2-TP53 pathway. High mRNA expression levels of PICT1 are associated with poor prognosis in several cancers with wild-type TP53...
  6. Porsch R, Merello E, De Marco P, Cheng G, Rodriguez L, So M, et al. Sacral agenesis: a pilot whole exome sequencing and copy number study. BMC Med Genet. 2016;17:98 pubmed publisher
    ..Importantly, predicted damaging mutations in PTEN (heterozygous), in its direct regulator GLTSCR2 (compound heterozygous) and in VANGL1 (heterozygous) were identified...
  7. Thoms M, Thomson E, Baßler J, Gnädig M, Griesel S, Hurt E. The Exosome Is Recruited to RNA Substrates through Specific Adaptor Proteins. Cell. 2015;162:1029-38 pubmed publisher
    ..Nop53, the yeast homolog of the tumor suppressor PICT1, targets Mtr4 to pre-ribosomal particles for exosome-mediated processing, while a second adaptor Utp18 recruits ..
  8. Kim J, Kim H, Lee S, Park J. The expression of GLTSCR2, a candidate tumor suppressor, is reduced in seborrheic keratosis compared to normal skin. Pathol Res Pract. 2010;206:295-9 pubmed publisher
    Glioma tumor-suppressor candidate region gene 2 (GLTSCR2) is a recently identified nuclear protein that interacts with the tumor suppressor PTEN...
  9. Kim J, Cho Y, Park J, Lee S. Expression of GLTSCR2/Pict-1 in squamous cell carcinomas of the skin. Arch Dermatol Res. 2013;305:797-804 pubmed publisher
    ..DNA damage induced by UV irradiation is sensed by early DNA damage response (DDR) proteins. Recently, GLTSCR2 has been suggested to play a role in UV light-induced DDR...
  10. Wang P, Meng W, Han S, Li C, Wang X, Wang X. The nucleolar protein GLTSCR2 is required for efficient viral replication. Sci Rep. 2016;6:36226 pubmed publisher
    b>Glioma tumor suppressor candidate region gene 2 protein (GLTSCR2) is a nucleolar protein...
  11. Rifatbegovic F, Frech C, Abbasi M, Taschner Mandl S, Weiss T, Schmidt W, et al. Neuroblastoma cells undergo transcriptomic alterations upon dissemination into the bone marrow and subsequent tumor progression. Int J Cancer. 2018;142:297-307 pubmed publisher
    ..downregulated genes on chromosome 19, including five tumor suppressor genes: SIRT6, BBC3/PUMA, STK11, CADM4 and GLTSCR2. This first RNA-Seq analysis of neuroblastoma DTCs revealed their unique expression profile in comparison to the ..
  12. Lee S, Cho Y, Kim S, Kim Y, Park J. GLTSCR2 promotes the nucleoplasmic translocation and subsequent degradation of nucleolar ARF. Oncotarget. 2017;8:16293-16302 pubmed publisher
    ..b>GLTSCR2 (also known as PICT-1) is a nucleolar protein involved in both tumor suppression and oncogenesis in concert with ..
  13. Lee S, Cho Y, Kim Y, Park J. c-Jun N-terminal kinase regulates the nucleoplasmic translocation and stability of nucleolar GLTSCR2 protein. Biochem Biophys Res Commun. 2016;472:95-100 pubmed publisher
    Glioblastoma tumor suppressive candidate region gene 2 (GLTSCR2) is a nucleolar protein that participates in critical cellular processes including the DNA damage response, cell cycle regulation, and inhibition of MYC-induced transforming ..
  14. Borodianskiy Shteinberg T, Kalt I, Kipper S, Nachum N, Katz S, Pauker M, et al. The nucleolar PICT-1/GLTSCR2 protein forms homo-oligomers. J Mol Biol. 2014;426:2363-78 pubmed publisher
    The human "protein interacting with carboxyl terminus 1" (PICT-1), also designated as the "glioma tumor suppressor candidate region 2 gene product", GLTSCR2, is a nucleolar protein whose activity is, as yet, unknown...
  15. Sloan K, Bohnsack M, Watkins N. The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress. Cell Rep. 2013;5:237-47 pubmed publisher determined by factors regulating 5S complex formation and ribosome integration, including the tumor suppressor PICT1. The 5S RNP therefore emerges as the critical coordinator of signaling pathways that couple cell proliferation ..
  16. Ishibashi M, Kogo R, Shibata K, Ueo H, Uchi R, Matsumura T, et al. Clinical significance of PICT1 in patients of hepatocellular carcinoma with wild-type TP53. Ann Surg Oncol. 2013;20 Suppl 3:S537-44 pubmed publisher
    ..We previously reported that PICT1, coding a nucleolus protein, regulates TP53 through indirect association...
  17. Uchi R, Kogo R, Kawahara K, Sudo T, Yokobori T, Eguchi H, et al. PICT1 regulates TP53 via RPL11 and is involved in gastric cancer progression. Br J Cancer. 2013;109:2199-206 pubmed publisher
    The TP53 pathway is frequently inactivated in human cancers. PICT1 (also known as GLTSCR2) is a novel regulator of the MDM2-TP53 pathway via its interaction with the ribosomal protein RPL11 in the nucleolus...
  18. Moon A, Lim S, Jo Y, Lee S, Kim J, Lee J, et al. Downregulation of GLTSCR2 expression is correlated with breast cancer progression. Pathol Res Pract. 2013;209:700-4 pubmed publisher
    Glioma tumor-suppressor candidate region gene2 (GLTSCR2) is a recently identified nucleolus-localized protein participating in the regulation of cell cycle progression and apoptosis...
  19. Chen H, Duo Y, Hu B, Wang Z, Zhang F, Tsai H, et al. PICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway. Oncotarget. 2016;7:78747-78763 pubmed publisher
    ..Our data show that PICT-1 triggers pro-death autophagy through inhibition of rRNA transcription and the inactivation of AKT/mTOR/p70S6K pathway, independent of nucleolar disruption and p53 activation. ..
  20. Kim J, Park J, Lee S. GLTSCR2 contributes to the death resistance and invasiveness of hypoxia-selected cancer cells. FEBS Lett. 2012;586:3435-40 pubmed publisher
    ..Our aim in this study was to investigate whether hypoxia-responsive GLTSCR2 contributes to death resistance and increased invasiveness of hypoxia-selected glioblastoma cells...
  21. Kim J, Cho Y, Park J. The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of the Oncogenic Nucleophosmin-MYC Axis. Am J Pathol. 2015;185:2061-8 pubmed publisher
    ..we describe a novel function of the nucleolar protein glioblastoma tumor-suppressive candidate region gene 2 (GLTSCR2) in regulating the transcriptional activity of MYC through an NPM-dependent pathway in SK-BR3 breast cancer cells...
  22. Kim J, Cho Y, Kim G, Lee H, Lee S, Park J. Down-regulation and aberrant cytoplasmic expression of GLTSCR2 in prostatic adenocarcinomas. Cancer Lett. 2013;340:134-40 pubmed publisher
    b>GLTSCR2 is a nuclear/nucleolar protein that translocates to the nucleoplasm, suppressed and mutated in human cancers...
  23. YOON J, Ling A, Isik M, Lee D, Steinbaugh M, Sack L, et al. GLTSCR2/PICT1 links mitochondrial stress and Myc signaling. Proc Natl Acad Sci U S A. 2014;111:3781-6 pubmed publisher
    ..The screen identified 94 candidate mitochondrial regulators including the nuclear protein GLTSCR2, also known as PICT1...
  24. Zhang J, Wang Q, Liu Y, Sun K, Zhang B, Jin Q, et al. The expression of GLTSCR2 in cervical intra-epithelial lesion and cancer. Arch Gynecol Obstet. 2015;291:413-8 pubmed publisher
    b>GLTSCR2 was originally identified as a candidate tumor suppressor in several types of cancers...
  25. Chen H, Han L, Tsai H, Wang Z, Wu Y, Duo Y, et al. PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway. Oncotarget. 2016;7:83241-83257 pubmed publisher
    ..These data indicate that PICT-1 is a major nucleolar sensor of the DNA damage repair response and an important upstream regulator of p53 via the RPL11-MDM2-p53 pathway. ..
  26. Li C, Dong H, Wang P, Meng W, Chi X, Han S, et al. Cellular protein GLTSCR2: A valuable target for the development of broad-spectrum antivirals. Antiviral Res. 2017;142:1-11 pubmed publisher
    Viral infection induces translocation of the nucleolar protein GLTSCR2 from the nucleus to the cytoplasm, resulting in attenuation of the type I interferon IFN-β...
  27. Cho Y, Lee H, Lim S, Kim Y, Choe B, Lee S, et al. Suppression of GLTSCR2 expression in renal cell carcinomas. Pathol Res Pract. 2016;212:120-4 pubmed publisher
    Nucleolar protein PICT-1/GLTSCR2 (GLTSCR2) has both tumor suppressive and oncogenic activities, depending on the types of cancer tissue and its expression level...
  28. Maehama T, Kawahara K, Nishio M, Suzuki A, Hanada K. Nucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1 protein. J Biol Chem. 2014;289:20802-12 pubmed
    The nucleolar protein PICT1 regulates tumor suppressor p53 by tethering ribosomal protein L11 within the nucleolus to repress the binding of L11 to the E3 ligase MDM2...
  29. Kim J, An Y, Park J. Role of GLTSCR2 in the regulation of telomerase activity and chromosome stability. Mol Med Rep. 2016;14:1697-703 pubmed publisher
    ..In the present study, the role of glioma tumor-suppressor candidate region gene 2 (GLTSCR2) in telomerase regulation was analyzed...
  30. Yoshimoto M, Tokuda A, Nishiwaki K, Sengoku K, Yaginuma Y. The protein interacting with carboxyl terminus-1 codon 389 polymorphism impairs protein interacting with carboxyl terminus-1 function and is a risk factor for uterine cervical cancer. Mol Carcinog. 2017;56:1484-1492 pubmed publisher
    ..Therefore, PICT-1 may play a critical role during the pathogenesis of uterine cervical cancers. ..
  31. Kim J, Cho Y, An Y, Kim S, Lee Y, Park J, et al. GLTSCR2 is an upstream negative regulator of nucleophosmin in cervical cancer. J Cell Mol Med. 2015;19:1245-52 pubmed publisher
    ..In this study, we showed that nucleolar protein GLTSCR2/Pict-1 induced nucleoplasmic translocation and enhanced the degradation of NPM via the proteasomal ..
  32. Kalt I, Levy A, Borodianskiy Shteinberg T, Sarid R. Nucleolar localization of GLTSCR2/PICT-1 is mediated by multiple unique nucleolar localization sequences. PLoS ONE. 2012;7:e30825 pubmed publisher
    The human glioma tumor suppressor candidate region 2 gene product, GLTSCR2, also called 'protein interacting with carboxyl terminus 1' (PICT-1), has been implicated in the regulation of two major tumor suppressor proteins, PTEN and p53, ..
  33. Sevinc A, Fung L. Non-erythroid beta spectrin interacting proteins and their effects on spectrin tetramerization. Cell Mol Biol Lett. 2011;16:595-609 pubmed publisher
    ..We also found that the syntaxin binding protein 1 fragment abolished ?II-N and ?II-C interaction, suggesting that this protein may inhibit or regulate non-erythroid spectrin tetramer formation. ..
  34. Yim J, Kim Y, Cho Y, Ko J, Kim S, Kim J, et al. GLTSCR2 sensitizes cells to hypoxic injury without involvement of mitochondrial apoptotic cascades. Pathobiology. 2007;74:301-8 pubmed
    ..Through this process the GLTSCR2 gene was found. The purpose of this work was to investigate the role of GLTSCR2 in hypoxic cell death pathways...