NOG

Summary

Gene Symbol: NOG
Description: noggin
Alias: SYM1, SYNS1, SYNS1A, noggin, symphalangism 1 (proximal)
Species: human
Products:     NOG

Top Publications

  1. Schwaninger R, Rentsch C, Wetterwald A, van der Horst G, van Bezooijen R, van der Pluijm G, et al. Lack of noggin expression by cancer cells is a determinant of the osteoblast response in bone metastases. Am J Pathol. 2007;170:160-75 pubmed
    ..Their activity is modulated by antagonists such as noggin and dickkopf-1...
  2. Shimizu R, Mitsui N, Mori Y, Cho S, Yamamori S, Osawa M, et al. Cryptic 17q22 deletion in a boy with a t(10;17)(p15.3;q22) translocation, multiple synostosis syndrome 1, and hypogonadotropic hypogonadism. Am J Med Genet A. 2008;146A:1458-61 pubmed publisher
    ..2-3.9 Mb deletion at 17q22. The deletion encompassed NOG, a gene responsible for multiple synostosis syndrome 1...
  3. Oxley C, Rashid R, Goudie D, Stranks G, Baty D, Lam W, et al. Growth and skeletal development in families with NOGGIN gene mutations. Horm Res. 2008;69:221-6 pubmed publisher
    There is a scarcity of data on height as well as bone densitometry in humans with NOGGIN mutations.
  4. Lucotte G, Houzet A, Hubans C, Lagarde J, Lenoir G. Mutations of the noggin (NOG) and of the activin A type I receptor (ACVR1) genes in a series of twenty-seven French fibrodysplasia ossificans progressiva (FOP) patients. Genet Couns. 2009;20:53-62 pubmed
    ..Two genes, the noggin (NOG) gene and the activin A type I receptor (ACVRI) gene, are involved in FOP...
  5. Brown D, Kim T, Petty E, Downs C, Martin D, Strouse P, et al. Autosomal dominant stapes ankylosis with broad thumbs and toes, hyperopia, and skeletal anomalies is caused by heterozygous nonsense and frameshift mutations in NOG, the gene encoding noggin. Am J Hum Genet. 2002;71:618-24 pubmed
    ..SYM1) or multiple-synostoses syndrome (SYNS1), both of which are caused by mutations in NOG, the gene encoding noggin. We describe a family that was ascertained to have nonsyndromic otosclerosis but was subsequently found to have a ..
  6. Lucotte G, Lagarde J. Mutations of the noggin and of the activin A type I receptor genes in fibrodysplasia ossificans progressiva (FOP). Genet Couns. 2007;18:349-52 pubmed
  7. Feeley B, Krenek L, Liu N, Hsu W, Gamradt S, Schwarz E, et al. Overexpression of noggin inhibits BMP-mediated growth of osteolytic prostate cancer lesions. Bone. 2006;38:154-66 pubmed
    ..vivo, PC-3 cells were injected alone, with an empty retroviral vector, or with a retroviral vector overexpressing noggin, into the tibias of SCID mice...
  8. Declau F, van den Ende J, Baten E, Mattelaer P. Stapes ankylosis in a family with a novel NOG mutation: otologic features of the facioaudiosymphalangism syndrome. Otol Neurotol. 2005;26:934-40 pubmed
    To report the phenotype-genotype correlation in a Belgian family that was ascertained to have a novel missense mutation in the NOG gene mapping to chromosome 17q22.
  9. Lehmann K, Seemann P, Silan F, Goecke T, Irgang S, Kjaer K, et al. A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN. Am J Hum Genet. 2007;81:388-96 pubmed
    ..point mutations (P35A, P35S, A36P, E48K, R167G, and P187S) in the bone morphogenetic protein (BMP) antagonist NOGGIN (NOG)...

More Information

Publications100

  1. Gong Y, Krakow D, Marcelino J, Wilkin D, Chitayat D, Babul Hirji R, et al. Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis. Nat Genet. 1999;21:302-4 pubmed
    The secreted polypeptide noggin (encoded by the Nog gene) binds and inactivates members of the transforming growth factor beta superfamily of signalling proteins (TGFbeta-FMs), such as BMP4 (ref. 1)...
  2. Brunet L, McMahon J, McMahon A, Harland R. Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science. 1998;280:1455-7 pubmed
    b>Noggin is a bone morphogenetic protein (BMP) antagonist expressed in Spemann's organizer. Murine Noggin is expressed in condensing cartilage and immature chondrocytes, as are many BMPs...
  3. Mangino M, Flex E, Digilio M, Giannotti A, Dallapiccola B. Identification of a novel NOG gene mutation (P35S) in an Italian family with symphalangism. Hum Mutat. 2002;19:308 pubmed
    ..A different mutation in the same codon (P35R) has been previously described. Comparison between different noggin gene hortologs shows that codon 35 is conserved...
  4. Debeer P, Fryns J, Devriendt K, Baten E, Huysmans C, Van de Ven W. A novel NOG mutation Pro37Arg in a family with tarsal and carpal synostoses. Am J Med Genet A. 2004;128A:439-40 pubmed
  5. Li W, LoTurco J. Noggin is a negative regulator of neuronal differentiation in developing neocortex. Dev Neurosci. 2000;22:68-73 pubmed
    ..b>Noggin binds to BMP-2/4 with high affinity, and prevents binding to cell surface receptors...
  6. Takahashi T, Takahashi I, Komatsu M, Sawaishi Y, Higashi K, Nishimura G, et al. Mutations of the NOG gene in individuals with proximal symphalangism and multiple synostosis syndrome. Clin Genet. 2001;60:447-51 pubmed
    ..Recently, it was reported that both disorders were caused by heterozygous mutations of the human noggin gene (NOG)...
  7. Dawson K, Seeman P, Sebald E, King L, Edwards M, Williams J, et al. GDF5 is a second locus for multiple-synostosis syndrome. Am J Hum Genet. 2006;78:708-12 pubmed
    ..Heterozygosity for functional null mutations in the NOGGIN gene has been shown to be responsible for the disorder...
  8. Keller S, Nickel J, Zhang J, Sebald W, Mueller T. Molecular recognition of BMP-2 and BMP receptor IA. Nat Struct Mol Biol. 2004;11:481-8 pubmed
    ..binding only, whereas its overall structure and its binding to type II receptors and modulator proteins, such as noggin, were unchanged. Thus, the L51P substitution converts BMP-2 into a receptor-inactive inhibitor of noggin...
  9. Dixon M, Armstrong P, Stevens D, Bamshad M. Identical mutations in NOG can cause either tarsal/carpal coalition syndrome or proximal symphalangism. Genet Med. 2001;3:349-53 pubmed
    ..To identify the gene causing tarsal/carpal coalition syndrome (TCC)...
  10. Song K, Krause C, Shi S, Patterson M, Suto R, Grgurevic L, et al. Identification of a key residue mediating bone morphogenetic protein (BMP)-6 resistance to noggin inhibition allows for engineered BMPs with superior agonist activity. J Biol Chem. 2010;285:12169-80 pubmed publisher
    ..Here we show that BMP-6 is more resistant to noggin inhibition and more potent in promoting osteoblast differentiation in vitro and inducing bone regeneration in vivo ..
  11. Schwaerzer G, Hiepen C, Schrewe H, Nickel J, Ploeger F, Sebald W, et al. New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance. J Bone Miner Res. 2012;27:429-42 pubmed publisher
    ..Antagonists such as noggin counteract BMP signaling by covering the ligand's BMP type I (BMPRI) and type II (BMPRII, ActRII, ActRIIB) ..
  12. Potti T, Petty E, Lesperance M. A comprehensive review of reported heritable noggin-associated syndromes and proposed clinical utility of one broadly inclusive diagnostic term: NOG-related-symphalangism spectrum disorder (NOG-SSD). Hum Mutat. 2011;32:877-86 pubmed publisher
    The NOG gene encodes noggin, a secreted polypeptide that is important for regulating multiple signaling pathways during human development, particularly in cartilage and bone...
  13. Zimmerman L, De Jesús Escobar J, Harland R. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell. 1996;86:599-606 pubmed
    ..The secreted polypeptide noggin mimics these activities and is expressed at the appropriate time and place to participate in the organizer signal...
  14. Groppe J, Greenwald J, Wiater E, Rodriguez Leon J, Economides A, Kwiatkowski W, et al. Structural basis of BMP signalling inhibition by the cystine knot protein Noggin. Nature. 2002;420:636-42 pubmed
    ..Here we report the crystal structure of the antagonist Noggin bound to BMP-7, which shows that Noggin inhibits BMP signalling by blocking the molecular interfaces of the ..
  15. McMahon J, Takada S, Zimmerman L, Fan C, Harland R, McMahon A. Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev. 1998;12:1438-52 pubmed
    ..We show that Noggin, which encodes a bone morphogenetic protein (BMP) antagonist expressed in the node, notochord, and dorsal somite, ..
  16. Kondo Y, Kimura O, Tanaka Y, Ninomiya M, Iwata T, Kogure T, et al. Differential Expression of CX3CL1 in Hepatitis B Virus-Replicating Hepatoma Cells Can Affect the Migration Activity of CX3CR1+ Immune Cells. J Virol. 2015;89:7016-27 pubmed publisher
    ..In addition to in vitro study, the analysis of immunohistochemistry with human samples and NOG mice with human lymphocytes and hepatoma cells supports this phenomenon...
  17. Merchant R, Bhatt N, Merchant M. Surgical Considerations for Massive Tarsal Coalitions in Multiple Synostosis Syndrome: A Case Report. J Foot Ankle Surg. 2015;54:1162-5 pubmed publisher
    ..coalition syndrome has been included in the spectrum of heritable disorders related to mutations in the NOG gene...
  18. Keytsman C, Eijnde B, Hansen D, Verboven K, Wens I. Elevated cardiovascular risk factors in multiple sclerosis. Mult Scler Relat Disord. 2017;17:220-223 pubmed publisher
    ..1.7 ± 0.2) were significantly (p < 0.05) elevated. Total cholesterol, blood HDL and LDL concentrations did nog differ between groups (p < 0.05)...
  19. Yu W, Qu H, Cao G, Liu C, Deng H, Zhang Z. MtHsp70-CLIC1-pulsed dendritic cells enhance the immune response against ovarian cancer. Biochem Biophys Res Commun. 2017;494:13-19 pubmed publisher
    ..and the antitumor effect of human cytotoxic T lymphocytes (CTLs) stimulated by autologous DCs was assessed in NOG mice...
  20. van der Maarel Wierink C, de Baat C. [Preventive dentistry 6. Prevention of caries in frail older people]. Ned Tijdschr Tandheelkd. 2017;124:303-307 pubmed publisher
    ..Tandpasta met 5.000 ppm is in Nederland (nog) niet verkrijgbaar. Op dit moment is het advies ‘Preventie van wortelcariës’ de enige richtlijn...
  21. Wazir U, Orakzai M, Martin T, Jiang W, Mokbel K. Correlation of TERT and Stem Cell Markers in the Context of Human Breast Cancer. Cancer Genomics Proteomics. 2019;16:121-127 pubmed publisher
    ..001), cluster of differentiation antigen 24 (CD24; n=88, p=0.0114), MET proto-oncogene (MET; n=78, p<0.001) and noggin (NOG; n=88, p<0.001)...
  22. Jin B, Wang C, Li J, Du X, Ding K, Pan J. Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/β-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia. Clin Cancer Res. 2017;23:789-803 pubmed publisher
    ..Niclosamide decreased the long-term engraftment of human CML LSCs in NOD-SCID IL2Rγ chain-deficient (NOG) mice, and prolonged the survival of CML mice...
  23. Guerrero J, Oliveira H, Aid R, Bareille R, Siadous R, Letourneur D, et al. Influence of the three-dimensional culture of human bone marrow mesenchymal stromal cells within a macroporous polysaccharides scaffold on Pannexin 1 and Pannexin 3. J Tissue Eng Regen Med. 2017;: pubmed publisher
    ..we evaluated Panx1 and Panx3 expression within the cellularized scaffolds upon subcutaneous implantation in NOG mice, where we could observe a more intense expression in the constructs than in the surrounding tissues in vivo...
  24. Ohshima S, Mori S, Shigenari A, Miyamoto A, Takasu M, Imaeda N, et al. Differentiation ability of multipotent hematopoietic stem/progenitor cells detected by a porcine specific anti-CD117 monoclonal antibody. Biosci Trends. 2014;8:308-15 pubmed publisher
    ..When the swine BM CD117+ cells were transplanted in vivo into immunodeficient NOG (NOD/SCID/IL-2gc-null) mice, a significant amount of swine CD45+ leukocytes, including CD3 positive T cells, were ..
  25. Huysmans M. [Preventive dentistry 10. Erosive tooth wear]. Ned Tijdschr Tandheelkd. 2018;125:217-222 pubmed publisher
    ..en fluoridemaatregelen, worden aanbevolen maar het wetenschappelijke bewijs voor hun effectiviteit is nog steeds beperkt...
  26. Wen X, Li X, Tang Y, Tang J, Zhou S, Xie Y, et al. Chondrocyte FGFR3 Regulates Bone Mass by Inhibiting Osteogenesis. J Biol Chem. 2016;291:24912-24921 pubmed
    ..osteoblasts by up-regulating the expressions of Ihh, Bmp2, Bmp4, Bmp7, Wnt4, and Tgf-?1, as well as down-regulating Nog expression...
  27. Kunihiro M, Fujii H, Miyagi T, Takahashi Y, Tanaka R, Fukushima T, et al. Heat Shock Enhances the Expression of the Human T Cell Leukemia Virus Type-I (HTLV-I) Trans-Activator (Tax) Antigen in Human HTLV-I Infected Primary and Cultured T Cells. Viruses. 2016;8: pubmed publisher
    ..and gp46 antigen expression in primary human CD4? T cells isolated from HTLV-I-infected humanized NOD/SCID/?c null (NOG) mice and HTLV-I carriers...
  28. Nambu J, Kobayashi T, Hashimoto M, Tashiro H, Sugino K, Shimamoto F, et al. h-prune affects anaplastic thyroid cancer invasion and metastasis. Oncol Rep. 2016;35:3445-52 pubmed publisher
    ..decreased expression of h-prune suppressed tumor invasion and pulmonary metastasis in a NOD/Shi-scid, IL-2R?null (NOG) mouse orthotopic thyroid cancer model...
  29. Yamada D, Iyoda T, Vizcardo R, Shimizu K, Sato Y, Endo T, et al. Efficient Regeneration of Human Vα24+ Invariant Natural Killer T Cells and Their Anti-Tumor Activity In Vivo. Stem Cells. 2016;34:2852-2860 pubmed publisher
    ..activity in tumor-bearing mice and can activate autologous NK cells upon activation by ligand-pulsed DCs in the NOG mouse model in vivo, further extending their therapeutic potential...
  30. Wei X, Lai Y, Li B, Qin L, Xu Y, Lin S, et al. CRISPR/Cas9-Mediated Deletion of Foxn1 in NOD/SCID/IL2rg-/- Mice Results in Severe Immunodeficiency. Sci Rep. 2017;7:7720 pubmed publisher
    ..but also exhibited improved capacity to graft both leukemic and solid tumor cells compared with NSI, NOG, and NDG mice...
  31. Nagase Zembutsu A, Hirotani K, Yamato M, Yamaguchi J, Takata T, Yoshida M, et al. Development of DS-5573a: A novel afucosylated mAb directed at B7-H3 with potent antitumor activity. Cancer Sci. 2016;107:674-81 pubmed publisher
    ..SCID mice (which have functional natural killer cells and macrophages), but little antitumor efficacy in NOG mice (which lack natural killer cells and have reduced macrophage function)...
  32. Li X, Xia C, Wang T, Liu L, Zhao Q, Yang D, et al. Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells. Stem Cell Res. 2017;21:32-39 pubmed publisher
    ..In our protocol, the derived hematopoietic progenitors failed to engraft in NOG mice, indicating the absence of long-term HSC from these progenitors...
  33. Adamová E, Janečková E, Kleparnik K, Matalova E. Caspases and osteogenic markers--in vitro screening of inhibition impact. In Vitro Cell Dev Biol Anim. 2016;52:144-8 pubmed publisher
    ..of several genes after caspase inhibition (Bmp1, Bmp5, Bmp6, Col10a1, Col2a1, Comp, Egf, Fgfr2, Gli1, Igf1, Nog, Phex, Sox9, Spp1)...
  34. Wang L, Su Z, Tai W, Zou Y, Xu X, Zhang C. The p53 Pathway Controls SOX2-Mediated Reprogramming in the Adult Mouse Spinal Cord. Cell Rep. 2016;17:891-903 pubmed publisher
    ..A neurotrophic milieu supported by BDNF and NOG can robustly enhance maturation of these iANBs into diverse but predominantly glutamatergic neurons...
  35. Bayat A, Fijalkowski I, Andersen T, Abdulmunem S, van den Ende J, Van Hul W. Further delineation of facioaudiosymphalangism syndrome: Description of a family with a novel NOG mutation and without hearing loss. Am J Med Genet A. 2016;170:1479-84 pubmed publisher
    Mutations in the NOG gene give rise to a wide range of clinical phenotypes. Noggin, the protein encoded by this gene is a secreted modulator of multiple pathways involved in both bone and joint development...
  36. Urshansky N, Mausner Fainberg K, Auriel E, Regev K, Bornstein N, Karni A. Reduced production of noggin by immune cells of patients with relapsing-remitting multiple sclerosis. J Neuroimmunol. 2011;232:171-8 pubmed publisher
    ..Recent studies revealed a putative role for noggin in both neurogenesis and oligodenrocytes development...
  37. Liu F, Huang Y, Liu L, Liang B, Qu Z, Huang G, et al. Identification of a novel NOG mutation in a Chinese family with proximal symphalangism. Clin Chim Acta. 2014;429:129-33 pubmed publisher
    Proximal symphalangism (SYM1) is an autosomal dominant disorder, mainly characterized by variable fusion of the proximal interphalangeal joints of the hands and feet...
  38. Akiyama Y, Nonomura C, Ashizawa T, Iizuka A, Kondou R, Miyata H, et al. The anti-tumor activity of the STAT3 inhibitor STX-0119 occurs via promotion of tumor-infiltrating lymphocyte accumulation in temozolomide-resistant glioblastoma cell line. Immunol Lett. 2017;190:20-25 pubmed publisher
    ..In the present study, an immune-deficient NOG mouse with the deletion of both MHC-class I and class II genes, an MHC-double knockout mouse (dKO-NOG), was ..
  39. Laurell T, Lundin J, Anderlid B, Gorski J, Grigelioniene G, Knight S, et al. Molecular and clinical delineation of the 17q22 microdeletion phenotype. Eur J Hum Genet. 2013;21:1085-92 pubmed publisher
    ..24 Mb and two genes; NOG and C17ORF67. The function of C17ORF67 is not known, whereas Noggin, the product of NOG, is essential for correct joint development...
  40. Hauburger A, von Einem S, Schwaerzer G, Buttstedt A, Zebisch M, Schräml M, et al. The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding. FEBS J. 2009;276:6386-98 pubmed publisher
    ..The data presented here suggest that the pro-domain of BMP-2 can alter the signalling properties of the growth factor by modulating the ability of the mature part to interact with the receptors. ..
  41. Li K, Lo S, Sung L, Liao Y, Chang Y, Hu Y. Improved calvarial bone repair by hASCs engineered with Cre/loxP-based baculovirus conferring prolonged BMP-2 and MiR-148b co-expression. J Tissue Eng Regen Med. 2016;: pubmed publisher
    ..Here it is revealed that miR-148b directly targets NOG, whose gene product (noggin) is an antagonist to BMPs and negatively regulates BMP-induced osteogenic differentiation and bone formation...
  42. Kwong F, Hoyland J, Evans C, Freemont A. Regional and cellular localisation of BMPs and their inhibitors' expression in human fractures. Int Orthop. 2009;33:281-8 pubmed publisher
    The objective of this study was to determine whether BMP-2 and -14, noggin, and chordin could be detected in human fractures and to assess their regional and cellular distribution...
  43. White K, Sabatino J, He M, Davis N, Tang N, Bearer C. Toluene disruption of the functions of L1 cell adhesion molecule at concentrations associated with occupational exposures. Pediatr Res. 2016;80:145-50 pubmed publisher
    ..L1 mediates neurite outgrowth (NOG) via signaling through ERK1/2, which require trafficking of L1 through lipid rafts...
  44. Chan S, Tekari A, Benneker L, Heini P, Gantenbein B. Osteogenic differentiation of bone marrow stromal cells is hindered by the presence of intervertebral disc cells. Arthritis Res Ther. 2015;18:29 pubmed publisher
    ..that secrete factors preventing disc calcification, such as bone morphogenetic protein (BMP) antagonists including noggin and members of the DAN (differential screening selected gene aberrative in neuroblastoma) family...
  45. Gerhart J, Hayes C, Scheinfeld V, Chernick M, Gilmour S, George Weinstein M. Myo/Nog cells in normal, wounded and tumor-bearing skin. Exp Dermatol. 2012;21:466-8 pubmed publisher
    ..presence of Myo/Nog cells that were originally discovered in the chick embryo by their expression of MyoD mRNA, noggin and the G8 antigen. Myo/Nog cells are the primary source of noggin in telogen hair follicles...
  46. Fajardo M, Liu C, Egol K. Levels of expression for BMP-7 and several BMP antagonists may play an integral role in a fracture nonunion: a pilot study. Clin Orthop Relat Res. 2009;467:3071-8 pubmed publisher
    ..of BMP-2, BMP-4, BMP-5, BMP-6, BMP-7, BMP-8; BMP receptor Types IA, IB, and II; and the BMP inhibitors chordin, Noggin, Drm (Gremlin), and follistatin were determined in the nonunion (fibrous tissue) and healing bone (callus tissue) ..
  47. Bittermann A, Wegner I, Noordman B, Vincent R, van der Heijden G, Grolman W. An introduction of genetics in otosclerosis: a systematic review. Otolaryngol Head Neck Surg. 2014;150:34-9 pubmed publisher
    ..These high-quality studies show that otosclerosis in Japanese patients is not linked to the NOG gene and that a polymorphism in the Sp1 binding site located on the COL1A1 gene is associated with otosclerosis as ..
  48. Maeda N, Ohashi T, Chagan Yasutan H, Hattori T, Takahashi Y, Harigae H, et al. Osteopontin-integrin interaction as a novel molecular target for antibody-mediated immunotherapy in adult T-cell leukemia. Retrovirology. 2015;12:99 pubmed publisher
    ..the possible application of anti-OPN monoclonal antibody (mAb) for ATL immunotherapy in NOD/Shi-scid,IL-2Rg (null) (NOG) mice...
  49. Tekari A, May R, Frauchiger D, Chan S, Benneker L, Gantenbein B. The BMP2 variant L51P restores the osteogenic differentiation of human mesenchymal stromal cells in the presence of intervertebral disc cells. Eur Cell Mater. 2017;33:197-210 pubmed publisher
    ..Endogenous expression of major BMP antagonists, namely Gremlin (GREM1), Noggin (NOG) and Chordin (CHRD) was detected in IVD-derived cells, with abundance in nucleus pulposus cells...
  50. Yang X, Yuan Q, Zheng Y, Ma H, Chen T, Zhao X. An engineered non-oxidative glycolysis pathway for acetone production in Escherichia coli. Biotechnol Lett. 2016;38:1359-65 pubmed publisher
    ..Escherichia coli genome-scale metabolic network suggested that the introduction of a non-oxidative glycolysis (NOG) pathway would improve the theoretical acetone yield from 1 to 1.5 mol acetone/mol glucose...
  51. Kai Y, Hikita H, Tatsumi T, Nakabori T, Saito Y, Morishita N, et al. Emergence of hepatitis C virus NS5A L31V plus Y93H variant upon treatment failure of daclatasvir and asunaprevir is relatively resistant to ledipasvir and NS5B polymerase nucleotide inhibitor GS-558093 in human hepatocyte chimeric mice. J Gastroenterol. 2015;50:1145-51 pubmed publisher
    ..TK-NOG human hepatocyte chimeric mice were inoculated with sera from a patient with treatment failure of asunaprevir/..
  52. Degenkolbe E, König J, Zimmer J, Walther M, Reißner C, Nickel J, et al. A GDF5 point mutation strikes twice--causing BDA1 and SYNS2. PLoS Genet. 2013;9:e1003846 pubmed publisher
    ..On the one hand insensitivity to the main GDF5 antagonist NOGGIN (NOG) leads to a GDF5 gain of function and subsequent SYNS2 phenotype...
  53. Ito R, Katano I, Kawai K, Yagoto M, Takahashi T, Ka Y, et al. A Novel Xenogeneic Graft-Versus-Host Disease Model for Investigating the Pathological Role of Human CD4+ or CD8+ T Cells Using Immunodeficient NOG Mice. Am J Transplant. 2017;17:1216-1228 pubmed publisher
    ..were purified from peripheral blood and were transplanted into immunodeficient NOD/Shi-scid IL2rgnull (NOG) mice. Human CD8+ T cells did not induce major GVHD symptoms in conventional NOG mice...
  54. Mangold E, Ludwig K, Birnbaum S, Baluardo C, Ferrian M, Herms S, et al. Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate. Nat Genet. 2010;42:24-6 pubmed publisher
    ..07 x 10(-8), relative risk in homozygotes = 1.84, 95% CI 1.34-2.53) and 10q25.3 (rs7078160, combined P = 1.92 x 10(-8), relative risk in homozygotes = 2.17, 95% CI 1.32-3.56). ..
  55. Pang X, Wang Z, Chai Y, Chen H, Li L, Sun L, et al. A Novel Missense Mutation of NOG Interferes With the Dimerization of NOG and Causes Proximal Symphalangism Syndrome in a Chinese Family. Ann Otol Rhinol Laryngol. 2015;124:745-51 pubmed publisher
    b>NOG is an antagonist to bone morphogenetic proteins and plays an important role in proper bone and joint development. Dominant mutations in NOG may lead to a series of symphalangism spectrum disorders...
  56. Zheng Y, Yuan Q, Yang X, Ma H. Engineering Escherichia coli for poly-(3-hydroxybutyrate) production guided by genome-scale metabolic network analysis. Enzyme Microb Technol. 2017;106:60-66 pubmed publisher
    ..coli, we found that the introduction of non-oxidative glycolysis pathway (NOG), a previously reported pathway enabling complete carbon conservation, can increase the theoretical carbon yield ..
  57. Aydin H, Altunoglu U, Uyguner Z, Ozkan T, Kayserili H. Multiple synostoses syndrome in three members of a family displaying a novel mutation in NOGGIN gene. J Plast Reconstr Aesthet Surg. 2013;66:e287-9 pubmed publisher
  58. Marcelino J, Sciortino C, Romero M, Ulatowski L, Ballock R, Economides A, et al. Human disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein binding. Proc Natl Acad Sci U S A. 2001;98:11353-8 pubmed
    Secreted noggin protein regulates bone morphogenetic protein activity during development...
  59. Chen D, Zhao M, Mundy G. Bone morphogenetic proteins. Growth Factors. 2004;22:233-41 pubmed
    ..A significant advancement about the understanding of in vivo functions of BMP ligands, receptors and signaling molecules has been achieved in recent years. ..
  60. Abe E, Yamamoto M, Taguchi Y, Lecka Czernik B, O Brien C, Economides A, et al. Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin. J Bone Miner Res. 2000;15:663-73 pubmed
    ..To do this, we took advantage of the properties of noggin, a recently discovered protein that binds BMP-2 and -4 and blocks their action...
  61. Masuda S, Namba K, Mutai H, Usui S, Miyanaga Y, Kaneko H, et al. A mutation in the heparin-binding site of noggin as a novel mechanism of proximal symphalangism and conductive hearing loss. Biochem Biophys Res Commun. 2014;447:496-502 pubmed publisher
    ..access of bone morphogenetic protein (BMP) to the BMP receptors on the cell surface is regulated by its antagonist noggin, which binds to heparan-sulfate proteoglycans on the cell surface...
  62. Brown D, Kim T, Petty E, Downs C, Martin D, Strouse P, et al. Characterization of a stapes ankylosis family with a NOG mutation. Otol Neurotol. 2003;24:210-5 pubmed
    ..family with autosomal dominant stapes ankylosis, hyperopia, and skeletal abnormalities caused by a mutation in the noggin gene (NOG). Case series. Academic tertiary care center. Eight affected and 3 unaffected family members...
  63. Liu W, Feng X, Ren C, Shi J, Yang X, Zhao M, et al. Critical role of Cys168 in noggin protein's biological function. Acta Biochim Biophys Sin (Shanghai). 2005;37:181-5 pubmed
    Previous studies have indicated that noggin exerts its neural inducing effect by binding and antagonizing bone morphogenetic protein 4 (BMP4)...
  64. Tarragona M, Pavlović M, Arnal Estapé A, Urosevic J, Morales M, Guiu M, et al. Identification of NOG as a specific breast cancer bone metastasis-supporting gene. J Biol Chem. 2012;287:21346-55 pubmed publisher
    ..We provide molecular evidence showing that the BMP inhibitor, NOG, provides metastatic breast cancer cells with the ability to colonize the bone...
  65. Sharov A, Mardaryev A, Sharova T, Grachtchouk M, Atoyan R, Byers H, et al. Bone morphogenetic protein antagonist noggin promotes skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways. Am J Pathol. 2009;175:1303-14 pubmed publisher
    ..To study the role of BMPs in skin tumorigenesis, BMP antagonist noggin was used to generate keratin 14-targeted transgenic mice...
  66. Das Bhowmik A, Salem Ramakumaran V, Dalal A. Tarsal-carpal coalition syndrome: Report of a novel missense mutation in NOG gene and phenotypic delineation. Am J Med Genet A. 2017;: pubmed publisher
    ..Sanger sequencing revealed a novel heterozygous missense mutation in NOG gene (NM_005450.4:c.611G>A) in all the affected individuals of the family...
  67. CHALAZONITIS A, Pham T, Li Z, Roman D, Guha U, Gomes W, et al. Bone morphogenetic protein regulation of enteric neuronal phenotypic diversity: relationship to timing of cell cycle exit. J Comp Neurol. 2008;509:474-92 pubmed publisher
    ..signaling on enteric neuron development were examined in transgenic mice overexpressing either the BMP inhibitor, noggin, or BMP4 under control of the neuron specific enolase (NSE) promoter...
  68. Kwong F, Hoyland J, Freemont A, Evans C. Altered relative expression of BMPs and BMP inhibitors in cartilaginous areas of human fractures progressing towards nonunion. J Orthop Res. 2009;27:752-7 pubmed publisher
    ..samples were examined by immunohistochemistry to determine the expression of BMP-2, BMP-14, and the BMP inhibitors noggin and chordin...
  69. Song T, Shi J, Guo Q, Lv K, Jiao X, Hu T, et al. Association between NOGGIN and SPRY2 polymorphisms and nonsyndromic cleft lip with or without cleft palate. Am J Med Genet A. 2015;167A:137-41 pubmed publisher
    ..The objective of this study was to investigate association of SNPs of noggin (NOG) and sprouty homolog 2 (SPRY2) with NSCLP risk...
  70. Westergaard Nielsen M, Amstrup T, Wanscher J, Brusgaard K, Ousager L. Autosomal dominant stapes fixation, syndactyly, and symphalangism in a family with NOG mutation: Long term follow-up on surgical treatment. Int J Pediatr Otorhinolaryngol. 2018;108:208-212 pubmed publisher
    ..Main outcome measure was audiologic results after stapedectomy. Sanger DNA sequencing of NOG was performed on peripheral blood...
  71. Gazzerro E, Canalis E. Bone morphogenetic proteins and their antagonists. Rev Endocr Metab Disord. 2006;7:51-65 pubmed
    ..Both intracellular and extracellular antagonists are regulated by BMPs, indicating the existence of local feedback mechanisms to modulate BMP cellular activities. ..
  72. Polymeropoulos M, Poush J, Rubenstein J, Francomano C. Localization of the gene (SYM1) for proximal symphalangism to human chromosome 17q21-q22. Genomics. 1995;27:225-9 pubmed
    ..We have established linkage for this disorder to markers on chromosome 17 (17q21-q22), with Zmax = 6.98 at theta = 0.05 with marker D17S790...
  73. Gutiérrez S, Gomez M, Rey J, Ochoa M, Gutiérrez S, Prieto J. Polymorphisms of the noggin gene and mandibular micrognathia: a first approximation. Acta Odontol Latinoam. 2010;23:13-9 pubmed
    ..Studies show that mutant mice for chd (chordin) and nog (noggin) genes, which are modulators of the Bone Morphogenic Protein (BMP), had mandibular defects ranging from mandibular ..
  74. Felder B, Stegmann K, Schultealbert A, Geller F, Strehl E, Ermert A, et al. Evaluation of BMP4 and its specific inhibitor NOG as candidates in human neural tube defects (NTDs). Eur J Hum Genet. 2002;10:753-6 pubmed
    ..Studies on animal models have shown that BMP4 and NOG are involved in the patterning of the neural tube...
  75. Srivastava K, Hu P, Solomon B, Ming J, Roessler E, Muenke M. Molecular analysis of the Noggin (NOG) gene in holoprosencephaly patients. Mol Genet Metab. 2012;106:241-3 pubmed publisher
    ..A recent report in mice described Noggin (NOG) as a candidate gene involved in the etiogenesis of microform HPE...
  76. Jespersen H, Lindberg M, Donia M, Söderberg E, Andersen R, Keller U, et al. Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model. Nat Commun. 2017;8:707 pubmed publisher
    ..patient are transplanted sequentially in non-obese diabetic/severe combined immune-deficient/common gamma chain (NOG/NSG) knockout mouse. Key to T-cell survival/effect in this model is the continuous presence of interleukin-2 (IL-2)...
  77. Andrieux J, Roche Lestienne C, Geffroy S, Desterke C, Grardel N, Plantier I, et al. Bone morphogenetic protein antagonist gene NOG is involved in myeloproliferative disease associated with myelofibrosis. Cancer Genet Cytogenet. 2007;178:11-6 pubmed
    ..All three cases exhibited a split of BACs containing NOG. The protein encoded by NOG, noggin, acts as an antagonist to bone morphogenetic secreted protein 2 and 4 (BMP2 and BMP4)...
  78. Lamb T, Harland R. Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern. Development. 1995;121:3627-36 pubmed
    ..Induction of anterior neural tissue could be mediated by noggin, a secreted polypeptide found in dorsal mesoderm...
  79. Peiris D, Pacheco I, Spencer C, Macleod R. The extracellular calcium-sensing receptor reciprocally regulates the secretion of BMP-2 and the BMP antagonist Noggin in colonic myofibroblasts. Am J Physiol Gastrointest Liver Physiol. 2007;292:G753-66 pubmed
    ..CaSR stimulation of T-84 epithelia and colonic myofibroblasts downregulated the BMP family antagonist Noggin, as assessed by RT-PCR and Western blot analysis...
  80. Chmielnicki E, Benraiss A, Economides A, Goldman S. Adenovirally expressed noggin and brain-derived neurotrophic factor cooperate to induce new medium spiny neurons from resident progenitor cells in the adult striatal ventricular zone. J Neurosci. 2004;24:2133-42 pubmed
    ..Here, we show that the overexpression of noggin, by acting to inhibit glial differentiation by subependymal progenitor cells, can potentiate adenoviral BDNF-..
  81. Murphy A, Li Y, Pietsch J, Chiang C, Lovvorn H. Mutational analysis of NOG in esophageal atresia and tracheoesophageal fistula patients. Pediatr Surg Int. 2012;28:335-40 pubmed publisher
    The NOG protein is a secretory antagonist of bone morphogenetic proteins (BMPs)...
  82. Krakow D, Reinker K, Powell B, Cantor R, Priore M, Garber A, et al. Localization of a multiple synostoses-syndrome disease gene to chromosome 17q21-22. Am J Hum Genet. 1998;63:120-4 pubmed
    ..These data provide evidence that multiple synostoses syndrome and proximal symphalangism may be allelic disorders. ..
  83. Ganaha A, Kaname T, Akazawa Y, Higa T, Shinjou A, Naritomi K, et al. Identification of two novel mutations in the NOG gene associated with congenital stapes ankylosis and symphalangism. J Hum Genet. 2015;60:27-34 pubmed publisher
    ..who were diagnosed with proximal symphalangism (SYM1), atypical multiple synostosis syndrome (atypical SYNS1) and stapes ankylosis with broad thumb and toes (SABTT), respectively, based on the clinical features...
  84. Chen C, Uludag H, Wang Z, Jiang H. Noggin suppression decreases BMP-2-induced osteogenesis of human bone marrow-derived mesenchymal stem cells in vitro. J Cell Biochem. 2012;113:3672-80 pubmed publisher
    Numerous studies with rodent cells and animal models indicate that noggin inhibits osteogenesis by antagonizing bone morphogenetic proteins (BMPs); however, the effect of noggin on osteogenesis of human cells remains ambiguous...
  85. Secondini C, Wetterwald A, Schwaninger R, Thalmann G, Cecchini M. The role of the BMP signaling antagonist noggin in the development of prostate cancer osteolytic bone metastasis. PLoS ONE. 2011;6:e16078 pubmed publisher
    ..Lack of expression of the BMP antagonist noggin by osteoinductive, carcinoma-derived cell lines is a determinant of the osteoblast response induced by their bone ..
  86. Al Chawa T, Ludwig K, Fier H, Pötzsch B, Reich R, Schmidt G, et al. Nonsyndromic cleft lip with or without cleft palate: Increased burden of rare variants within Gremlin-1, a component of the bone morphogenetic protein 4 pathway. Birth Defects Res A Clin Mol Teratol. 2014;100:493-8 pubmed publisher
    The genes Gremlin-1 (GREM1) and Noggin (NOG) are components of the bone morphogenetic protein 4 pathway, which has been implicated in craniofacial development...
  87. Yuen H, McCrudden C, Grills C, Zhang S, Huang Y, Chan K, et al. Combinatorial use of bone morphogenetic protein 6, noggin and SOST significantly predicts cancer progression. Cancer Sci. 2012;103:1145-54 pubmed publisher
    ..The signaling of BMP family members is tightly regulated by their antagonists, including noggin and SOST, which are, in turn, positively regulated by BMP, thereby forming a negative feedback loop...
  88. Usami S, Abe S, Nishio S, Sakurai Y, Kojima H, Tono T, et al. Mutations in the NOG gene are commonly found in congenital stapes ankylosis with symphalangism, but not in otosclerosis. Clin Genet. 2012;82:514-20 pubmed publisher
    Human noggin (NOG) is a responsible gene for multiple synostosis syndrome (SYNS1) and proximal symphalangism (SYM1), two conditions that are recently known to be within a wider range of clinical manifestations of stapes ankylosis with ..
  89. Beck H, Drahushuk K, Jacoby D, Higgins D, Lein P. Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons. BMC Neurosci. 2001;2:12 pubmed
    ..The dendrite-promoting activity of BMP-5 is significantly inhibited by the BMP antagonists noggin and follistatin and by a BMPR-IA-Fc chimeric protein...
  90. MacLeod A, Treuting P, Carlson C. Proliferative Cartilaginous Lesions in the Calcaneal Tendons of huNOG Mice. Toxicol Pathol. 2017;45:952-956 pubmed publisher
    NOD/Shi-scid/IL-2R?null (NOG) mice are humanized with CD34+ hematopoietic cells (huNOG mice) and are commonly utilized for biological or medical research on human therapeutics...
  91. Choi M, Stottmann R, Yang Y, Meyers E, Klingensmith J. The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis. Circ Res. 2007;100:220-8 pubmed
    ..Here we address the functions of Noggin, a dedicated BMP antagonist, in the developing mouse heart...