NLRP1

Summary

Gene Symbol: NLRP1
Description: NLR family pyrin domain containing 1
Alias: AIADK, CARD7, CIDED, CLR17.1, DEFCAP, DEFCAP-L/S, MSPC, NAC, NALP1, PP1044, SLEV1, VAMAS1, NACHT, LRR and PYD domains-containing protein 1, NACHT, LRR and PYD containing protein 1, NACHT, leucine rich repeat and PYD (pyrin domain) containing 1, NACHT, leucine rich repeat and PYD containing 1, caspase recruitment domain protein 7, caspase recruitment domain-containing protein 7, death effector filament-forming Ced-4-like apoptosis protein, nucleotide-binding domain and caspase recruitment domain, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1
Species: human
Products:     NLRP1

Top Publications

  1. Martinon F, Hofmann K, Tschopp J. The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation. Curr Biol. 2001;11:R118-20 pubmed
  2. Damiano J, Stehlik C, Pio F, Godzik A, Reed J. CLAN, a novel human CED-4-like gene. Genomics. 2001;75:77-83 pubmed
    ..The CARD of the CLAN proteins binds a number of other CARD-containing proteins including caspase-1, BCL10, NOD2, and NAC. Once their physiologic functions are uncovered, CLAN proteins may prove to be valuable therapeutic targets.
  3. Kummer J, Broekhuizen R, Everett H, Agostini L, Kuijk L, Martinon F, et al. Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. J Histochem Cytochem. 2007;55:443-52 pubmed
    ..NALP3 and NALP1 proteins can assemble to inflammasomes that activate caspase-1, resulting in the processing of pro-inflammatory ..
  4. Faustin B, Chen Y, Zhai D, Le Negrate G, Lartigue L, Satterthwait A, et al. Mechanism of Bcl-2 and Bcl-X(L) inhibition of NLRP1 inflammasome: loop domain-dependent suppression of ATP binding and oligomerization. Proc Natl Acad Sci U S A. 2009;106:3935-40 pubmed publisher
    b>NLRP1 (NLR family, pyrin domain-containing 1) is a contributor to innate immunity involved in intracellular sensing of pathogens, as well as danger signals related to cell injury...
  5. Schroder K, Tschopp J. The inflammasomes. Cell. 2010;140:821-32 pubmed publisher
    ..Agonists and activation mechanisms of the NLRP1, NLRP3, IPAF, and AIM2 inflammasomes are discussed...
  6. Damiano J, Oliveira V, Welsh K, Reed J. Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses. Biochem J. 2004;381:213-9 pubmed
    ..CLAN was found to associate with Nod1, Nod2 and NAC [nucleotide-binding domain and CARD-containing protein; NALP1 (NACHT, LRR and PYRIN protein 1)] when co-expressed in HEK-293T (human embryonic kidney) cells...
  7. Witola W, Mui E, Hargrave A, Liu S, Hypolite M, Montpetit A, et al. NALP1 influences susceptibility to human congenital toxoplasmosis, proinflammatory cytokine response, and fate of Toxoplasma gondii-infected monocytic cells. Infect Immun. 2011;79:756-66 pubmed publisher
    b>NALP1 is a member of the NOD-like receptor (NLR) family of proteins that form inflammasomes...
  8. Sui J, Li H, Fang Y, Liu Y, Li M, Zhong B, et al. NLRP1 gene polymorphism influences gene transcription and is a risk factor for rheumatoid arthritis in han chinese. Arthritis Rheum. 2012;64:647-54 pubmed publisher
    The inflammasome-related protein NLRP1/NALP1 has been implicated in the onset and progression of some autoimmune diseases...
  9. Chu Z, Pio F, Xie Z, Welsh K, Krajewska M, Krajewski S, et al. A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis. J Biol Chem. 2001;276:9239-45 pubmed
    ..A novel human protein was identified, NAC, that contains an NB domain and CARD...

More Information

Publications129 found, 100 shown here

  1. Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell. 2002;10:417-26 pubmed
    ..The inflammasome comprises caspase-1, caspase-5, Pycard/Asc, and NALP1, a Pyrin domain-containing protein sharing structural homology with NODs...
  2. Tschopp J, Martinon F, Burns K. NALPs: a novel protein family involved in inflammation. Nat Rev Mol Cell Biol. 2003;4:95-104 pubmed
    ..related apoptotic protease-activating factor-1 (APAF-1), which is responsible for the activation of caspase-9, the NALP1 protein forms a large, signal-induced multiprotein complex, the inflammasome, resulting in the activation of pro-..
  3. Hsu L, Ali S, McGillivray S, Tseng P, Mariathasan S, Humke E, et al. A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc Natl Acad Sci U S A. 2008;105:7803-8 pubmed publisher
    ..MDP challenge induces the association of NOD2 with another NLR protein, NALP1, and gel filtration analysis revealed the formation of a complex consisting of NOD2, NALP1, and caspase-1...
  4. Hlaing T, Guo R, Dilley K, Loussia J, Morrish T, Shi M, et al. Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins. J Biol Chem. 2001;276:9230-8 pubmed
    We report the deduced amino acid sequences of two alternately spliced isoforms, designated DEFCAP-L and -S, that differ in 44 amino acids and encode a novel member of the mammalian Ced-4 family of apoptosis proteins...
  5. Jin Y, Mailloux C, Gowan K, Riccardi S, Laberge G, Bennett D, et al. NALP1 in vitiligo-associated multiple autoimmune disease. N Engl J Med. 2007;356:1216-25 pubmed
    ..Association analyses resulted in our identifying as a candidate gene NALP1, which encodes NACHT leucine-rich-repeat protein 1, a regulator of the innate immune system...
  6. Bruey J, Bruey Sedano N, Luciano F, Zhai D, Balpai R, Xu C, et al. Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1. Cell. 2007;129:45-56 pubmed
    ..We have identified a mammalian analog of this caspase-regulatory system in the NLR-family protein NALP1, a nucleotide-dependent activator of cytokine-processing protease caspase-1, which responds to bacterial ligand ..
  7. Valero T. Mitochondrial biogenesis: pharmacological approaches. Curr Pharm Des. 2014;20:5507-9 pubmed
    ..such as L-carnitine, coenzyme Q10,MitoQ10 and other mitochondria-targeted antioxidants,N-acetylcysteine (NAC), vitamin C, vitamin E vitamin K1, vitamin B, sodium pyruvate or -lipoic acid...
  8. Banerjee S, Aykin Burns N, Krager K, Shah S, Melnyk S, Hauer Jensen M, et al. Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction. Free Radic Biol Med. 2016;99:296-307 pubmed publisher
    ..We further showed that pre-treatment with the GSH precursor, N-acetyl L-cysteine (NAC) prior to irradiation showed a significant reduction of IR-induced cell death and increases in GSH levels, which ..
  9. Ahn S, Kim Y, Kim H, Choi Y, Lee J, Kim C, et al. Neuroprotection and spatial memory enhancement of four herbal mixture extract in HT22 hippocampal cells and a mouse model of focal cerebral ischemia. BMC Complement Altern Med. 2015;15:202 pubmed publisher
    ..PI3K) by glutamate exposure were recovered by pretreatment with either PMC-12 or anti-oxidant N-acetyl-L-cysteine (NAC)...
  10. Al Omairi N, Al Brakati A, Kassab R, Lokman M, Elmahallawy E, Amin H, et al. Soursop fruit extract mitigates scopolamine-induced amnesia and oxidative stress via activating cholinergic and Nrf2/HO-1 pathways. Metab Brain Dis. 2019;: pubmed publisher
    ..Thirty-five rats were randomly allocated into 5 groups: control, SCO, SSFE, SCO, SSFE+SCO and N-acetylcysteine (NAC) + SCO...
  11. Guo Q, Wu Y, Hou Y, Liu Y, Liu T, Zhang H, et al. Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis. Front Immunol. 2018;9:1197 pubmed publisher
    ..Expression of several inflammasome components, the NOD-like receptor (NLR) family pyrin domain containing 1 (NLRP1), NLRP3, CARD-domain containing 4 (NLRC4), absent in melanoma 2 (AIM2), the apoptosis-associated speck-like ..
  12. Manna A, De Sarkar S, De S, Bauri A, Chattopadhyay S, Chatterjee M. The variable chemotherapeutic response of Malabaricone-A in leukemic and solid tumor cell lines depends on the degree of redox imbalance. Phytomedicine. 2015;22:713-23 pubmed publisher
    ..in MAL-A induced cytotoxicity was confirmed by pre-incubating cells with an antioxidant, N-acetyl-L-cysteine (NAC) or a thiol depletor, buthionine sulfoximine (BSO)...
  13. Pan Y, Luo Z, Zhuo M, Wei C, Chen G, Song Y. Oxidative stress and mitochondrial dysfunction mediated Cd-induced hepatic lipid accumulation in zebrafish Danio rerio. Aquat Toxicol. 2018;199:12-20 pubmed publisher
    ..To elucidate the mechanism, reactive oxygen species (ROS) scavenger N-acetylcysteine (NAC) and the mitochondrial permeability transition (MPT) inhibitor cyclosporine A (CsA) were used to verify the role of ..
  14. Adhami N, Starck S, Flores C, Martins Green M. A Health Threat to Bystanders Living in the Homes of Smokers: How Smoke Toxins Deposited on Surfaces Can Cause Insulin Resistance. PLoS ONE. 2016;11:e0149510 pubmed publisher
    ..are due to increase in oxidative stress, we treated mice exposed to THS with the antioxidants N-acetyl cysteine (NAC) and alpha-tocopherol (alpha-toc) and showed that the oxidative stress, the molecular damage, and the insulin ..
  15. Wu J, Zhu Y, Hu Y. Mechanism of feedback regulation of neutrophil inflammation in Henoch-Schönlein purpura. Eur Rev Med Pharmacol Sci. 2016;20:4277-4285 pubmed
    ..In the meantime, N-Acetyl-L-Cysteine (NAC)and hydrogen peroxide (H2O2) treatment was used to manipulate ROS level and determined the changes in ..
  16. Zhao P, Chen L, Li L, Wei Z, Tong B, Jia Y, et al. SC-III3, a novel scopoletin derivative, induces cytotoxicity in hepatocellular cancer cells through oxidative DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation. BMC Cancer. 2014;14:987 pubmed publisher
    ..Pretreatment with N-acetyl-l-cysteine (NAC), a ROS scavenger, could reverse SC-III3-caused ROS accumulation, DNA damage, activation of signal pathways ..
  17. He Y, Zhou L, Fan Z, Liu S, Fang W. Palmitic acid, but not high-glucose, induced myocardial apoptosis is alleviated by N?acetylcysteine due to attenuated mitochondrial-derived ROS accumulation-induced endoplasmic reticulum stress. Cell Death Dis. 2018;9:568 pubmed publisher
    ..This study was designed to investigate precise effects of antioxidant N?acetylcysteine (NAC) in alleviating diabetic cardiomyopathy (DCM)...
  18. Lin C, Hsiao L, Cho R, Yang C. CO-Releasing Molecule-2 Induces Nrf2/ARE-Dependent Heme Oxygenase-1 Expression Suppressing TNF-α-Induced Pulmonary Inflammation. J Clin Med. 2019;8: pubmed publisher
    ..their pharmacological inhibitors, including diphenyleneiodonium (DPI) or apocynin (APO), ROS [N-acetyl-L-cysteine (NAC)], PP1, AG1478, PI3K (LY294002), or Akt (SH-5), and small interfering RNAs (siRNAs)...
  19. So K, Lee B, Oh S. The critical role of autophagy in cadmium-induced immunosuppression regulated by endoplasmic reticulum stress-mediated calpain activation in RAW264.7 mouse monocytes. Toxicology. 2018;393:15-25 pubmed publisher
    ..Treatment with N-acetyl-l-cysteine (NAC) suppressed Cd-induced antioxidant enzyme levels, apoptosis, and autophagy...
  20. Ohtani M, Morisaki K, Sawada Y, Sano R, Uy A, Yamamoto A, et al. Primary Metabolism during Biosynthesis of Secondary Wall Polymers of Protoxylem Vessel Elements. Plant Physiol. 2016;172:1612-1624 pubmed
    ..These processes are regulated by the VASCULAR-RELATED NAC-DOMAIN (VND) transcription factors...
  21. Hsu P, Lin C, Chang J, Wu C, Sia K, Lee I, et al. Participation of NADPH Oxidase-Related Reactive Oxygen Species in Leptin-Promoted Pulmonary Inflammation: Regulation of cPLA2α and COX-2 Expression. Int J Mol Sci. 2019;20: pubmed publisher
    ..Treatment with an ROS scavenger (N-acetylcysteine, NAC), an NADPH oxidase inhibitor (apocynin), or an activating protein (AP)-1 inhibitor (tanshinone IIA) attenuated ..
  22. Köse S, Nazıroğlu M. N-acetyl cysteine reduces oxidative toxicity, apoptosis, and calcium entry through TRPV1 channels in the neutrophils of patients with polycystic ovary syndrome. Free Radic Res. 2015;49:338-46 pubmed publisher
    ..N-acetyl cysteine (NAC) decreases oxidative stress, intracellular free calcium ion [Ca(2+)]i, and apoptosis levels in human neutrophil...
  23. Hu Z, Lv G, Li Y, Li E, Li H, Zhou Q, et al. Enhancement of anti-tumor effects of 5-fluorouracil on hepatocellular carcinoma by low-intensity ultrasound. J Exp Clin Cancer Res. 2016;35:71 pubmed publisher
    ..Such enhanced effects could be partially blocked by the ROS scavenger N-acetylcysteine (NAC)...
  24. Salas Perez R, Saski C, Noorai R, Srivastava S, Lawton Rauh A, Nichols R, et al. RNA-Seq transcriptome analysis of Amaranthus palmeri with differential tolerance to glufosinate herbicide. PLoS ONE. 2018;13:e0195488 pubmed publisher
    ..Glufosinate-tolerant plants had greater induction of ABC transporter, glutathione S-transferase (GST), NAC transcription factor, nitronate monooxygenase (NMO), chitin elicitor receptor kinase (CERK1), heat shock protein 83,..
  25. Zheng S, Zhong Z, Qin S, Chen G, Wu Q, Zeng J, et al. Advanced oxidation protein products induce inflammatory response in fibroblast-like synoviocytes through NADPH oxidase -dependent activation of NF-κB. Cell Physiol Biochem. 2013;32:972-85 pubmed publisher
    ..treatment triggered ROS production in FLSs, which was significantly abolished by ROS scavenger N-acetyl-L-cysteine (NAC), superoxide dismutase (SOD), NADPH oxidase inhibitors diphenyleneiodonium (DPI) and apocynin...
  26. Chen J, Lazarenko O, Shankar K, Blackburn M, Badger T, Ronis M. A role for ethanol-induced oxidative stress in controlling lineage commitment of mesenchymal stromal cells through inhibition of Wnt/beta-catenin signaling. J Bone Miner Res. 2010;25:1117-27 pubmed publisher
    ..Coadministration of the antioxidant N-acetylcysteine (NAC) was able to block bone loss and downregulation of the bone-formation markers alkaline phosphatase and osteocalcin ..
  27. Salazar G, Huang J, Feresin R, Zhao Y, Griendling K. Zinc regulates Nox1 expression through a NF-?B and mitochondrial ROS dependent mechanism to induce senescence of vascular smooth muscle cells. Free Radic Biol Med. 2017;108:225-235 pubmed publisher
    ..of transcription, by inhibition of NF-?B, a known Nox1 transcriptional regulator and by N-acetyl cysteine (NAC) and MitoTEMPO, suggesting that NF-?B and mitochondrial ROS mediate zinc effects...
  28. Lin C, Huang P, Lai C, Chen J, Lin S, Chen J. Simvastatin Attenuates Oxidative Stress, NF-κB Activation, and Artery Calcification in LDLR-/- Mice Fed with High Fat Diet via Down-regulation of Tumor Necrosis Factor-α and TNF Receptor 1. PLoS ONE. 2015;10:e0143686 pubmed publisher
    ..SIM, N-acetyl cysteine (NAC, a ROS scavenger) and apocynin (APO, a NADPH oxidase inhibitor) did not significantly retard the development of ..
  29. Kalyanasundar B, Perez C, Luna A, Solorio J, Moreno M, Elias D, et al. D1 and D2 antagonists reverse the effects of appetite suppressants on weight loss, food intake, locomotion, and rebalance spiking inhibition in the rat NAc shell. J Neurophysiol. 2015;114:585-607 pubmed publisher
    ..The nucleus accumbens (NAc) shell receives dopaminergic inputs and is involved in feeding and motor activity...
  30. Liang Y, Lü B, Chen X, Qin J, Cheng X, Xie X, et al. Prognostic value of pathological response to neoadjuvant chemotherapy in bulky stage Ib2 and IIa cervical squamous cell cancer patients. Virchows Arch. 2016;468:329-36 pubmed publisher
    Neoadjuvant chemotherapy (NAC) is widely used to treat patients with locally advanced cervical cancer...
  31. Schmid R, Hovda L. Acute Hepatic Failure in a Dog after Xylitol Ingestion. J Med Toxicol. 2016;12:201-5 pubmed publisher
    ..N-acetylcysteine (NAC) and S-adensoyl-L-methionine (SAMe) provided hepatic detoxification and support...
  32. Liu J, Quan J, Feng J, Zhang Q, Xu Y, Liu J, et al. High glucose regulates LN expression in human liver sinusoidal endothelial cells through ROS/integrin αvβ3 pathway. Environ Toxicol Pharmacol. 2016;42:231-6 pubmed publisher
    ..were cultured and treated with media containing 25 mM glucose in the presence or absence of N-acetylcysteine (NAC) or clone LM609...
  33. Abdelzaher L, Imaizumi T, Suzuki T, Tomita K, Takashina M, Hattori Y. Astaxanthin alleviates oxidative stress insults-related derangements in human vascular endothelial cells exposed to glucose fluctuations. Life Sci. 2016;150:24-31 pubmed publisher
    ..5mM glucose alternating with 22 mM glucose in the absence or presence of astaxanthin or N-acetyl-L-cysteine (NAC)...
  34. Zhong R, Teng Q, Haghighat M, Yuan Y, Furey S, Dasher R, et al. Cytosol-Localized UDP-Xylose Synthases Provide the Major Source of UDP-Xylose for the Biosynthesis of Xylan and Xyloglucan. Plant Cell Physiol. 2017;58:156-174 pubmed publisher
    ..consistent with the finding that the expression of UXS3, UXS5 and UXS6 was directly activated by the secondary wall NAC master switches...
  35. Singh N, Inoue M, Osawa R, Wagener M, Shinohara M. Inflammasome expression and cytomegalovirus viremia in critically ill patients with sepsis. J Clin Virol. 2017;93:8-14 pubmed publisher
    ..Blood samples to evaluate mRNA levels of genes encoding CASP1, ASC, NLRP1, NLRP3, and NLRP12 were collected at the time of enrollment...
  36. Wan C, Xue R, Zhan Y, Wu Y, Li X, Pei F. Metabolomic Analysis of N-acetylcysteine Protection of Injury from Gadolinium-DTPA Contrast Agent in Rats with Chronic Renal Failure. OMICS. 2017;21:540-549 pubmed
    ..NSF is a systemic disorder characterized by widespread tissue fibrosis that may lead to death. N-acetylcysteine (NAC) protects rats from injury induced by gadolinium-based contrast agents, but the underlying mechanisms remain ..
  37. Sepehrmanesh Z, Heidary M, Akasheh N, Akbari H, Heidary M. Therapeutic effect of adjunctive N-acetyl cysteine (NAC) on symptoms of chronic schizophrenia: A double-blind, randomized clinical trial. Prog Neuropsychopharmacol Biol Psychiatry. 2018;82:289-296 pubmed publisher
    ..Current evidence indicates the roles of glutamatergic system in this disorder. N-acetyl cysteine (NAC) also increases extracellular glutamate...
  38. Polyak E, Ostrovsky J, Peng M, Dingley S, Tsukikawa M, Kwon Y, et al. N-acetylcysteine and vitamin E rescue animal longevity and cellular oxidative stress in pre-clinical models of mitochondrial complex I disease. Mol Genet Metab. 2018;123:449-462 pubmed publisher
    ..Here, lifespan effects of N-acetylcysteine (NAC), vitamin E, vitamin C, coenzyme Q10 (CoQ10), mitochondrial-targeted CoQ10 (MS010), lipoate, and orotate were ..
  39. Yang Y, Zhu K, Wu J, Liu L, Sun G, He Y, et al. Identification and characterization of a novel NAC-like gene in chrysanthemum (Dendranthema lavandulifolium). Plant Cell Rep. 2016;35:1783-98 pubmed publisher
    A NAC -like gene named DlNAC1 was identified in chrysanthemum and characterized; it may be involved in regulation of response to abiotic stressors, especially in tolerance to drought and salinity...
  40. Henderson P, Chang M, Taylor E, Weinreb R, Rohde C. The "Superior Ledge": a Modification of the Standard Superomedial Pedicle Reduction Mammoplasty to Accentuate Nipple-Areola Complex Projection. Aesthetic Plast Surg. 2016;40:733-8 pubmed publisher
    ..to the pedicle, thereby leaving a "superior ledge" of parenchyma on top of which the nipple-areola complex (NAC) rests in a tension-free manner...
  41. Zibara K, Zeidan A, Bjeije H, Kassem N, Badran B, El Zein N. ROS mediates interferon gamma induced phosphorylation of Src, through the Raf/ERK pathway, in MCF-7 human breast cancer cell line. J Cell Commun Signal. 2017;11:57-67 pubmed publisher
    ..in ROS generation, through H2O2 production, whereas pre-treatment with the ROS inhibitor NAC caused ROS inhibition and a significant decrease in the phosphorylation levels of AKT, ERK1/2, p38 and STAT1...
  42. De Santis M, Lian J, Huang X, Deng C. Early Antipsychotic Treatment in Juvenile Rats Elicits Long-Term Alterations to the Dopamine Neurotransmitter System. Int J Mol Sci. 2016;17: pubmed
    ..Olanzapine decreased PFC p-TH levels and increased D? receptor expression in the PFC and nucleus accumbens (NAc) in females only...
  43. Chi Y, Melencion S, Alinapon C, Kim M, Lee E, Paeng S, et al. The membrane-tethered NAC transcription factor, AtNTL7, contributes to ER-stress resistance in Arabidopsis. Biochem Biophys Res Commun. 2017;488:641-647 pubmed publisher
    We screened for endoplasmic reticulum (ER) stress-resistant mutants among 25 mutants of the Arabidopsis NTL (NAC with Transmembrane motif 1-Like) family. We identified a novel mutant, SALK_044777, showing strong resistance to ER stress...
  44. Bhushan B, Chavan H, Borude P, Xie Y, Du K, McGill M, et al. Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice. Toxicol Sci. 2017;155:363-378 pubmed publisher
    ..Treatment with N-acetylcysteine (NAC), 4h post-APAP in mice did not show any protection but treatment of EGFRi in combination with NAC showed decrease ..
  45. Li Z, Duan X, Min X, Zhou Z. Methylglyoxal as a novel signal molecule induces the salt tolerance of wheat by regulating the glyoxalase system, the antioxidant system, and osmolytes. Protoplasma. 2017;254:1995-2006 pubmed publisher
    ..effects of NaCl were alleviated by applying exogenous MG, but aggravated by the MG scavenger N-acetyl-L-cysteine (NAC), suggesting that MG could induce the salt tolerance of wheat...
  46. Chang C, Hseu Y, Thiyagarajan V, Lin K, Way T, Korivi M, et al. Chalcone flavokawain B induces autophagic-cell death via reactive oxygen species-mediated signaling pathways in human gastric carcinoma and suppresses tumor growth in nude mice. Arch Toxicol. 2017;91:3341-3364 pubmed publisher
    ..FKB-triggered ROS generation and ROS inhibition by NAC pre-treatment diminished FKB-induced cell death, LC3 conversion, AVO formation, p62/SQSTM1 activation, ATG4B ..
  47. Nishiyama K, Suzuki H, Harasawa T, Suzuki N, Kurimoto E, Kawai T, et al. FTBMT, a Novel and Selective GPR52 Agonist, Demonstrates Antipsychotic-Like and Procognitive Effects in Rodents, Revealing a Potential Therapeutic Agent for Schizophrenia. J Pharmacol Exp Ther. 2017;363:253-264 pubmed publisher
    ..is a Gs-coupled G protein-coupled receptor that is predominantly expressed in the striatum and nucleus accumbens (NAc) and was recently proposed as a potential therapeutic target for schizophrenia...
  48. Khalil Khalili M, Rashidy Pour A, Bandegi A, Yousefi B, Jorjani H, Miladi Gorji H. Effects of BDNF receptor antagonist on the severity of physical and psychological dependence, morphine-induced locomotor sensitization and the ventral tegmental area-nucleus accumbens BDNF levels in morphine- dependent and withdrawn rats. Neurosci Lett. 2018;668:7-12 pubmed publisher
    ..dependence and morphine-induced locomotor sensitization, the ventral tegmental area (VTA)-nucleus accumbens (NAc) BDNF levels in morphine-dependent and withdrawn rats...
  49. Sasada S, Masumoto N, Goda N, Kajitani K, Emi A, Kadoya T, et al. Dedicated breast PET for detecting residual disease after neoadjuvant chemotherapy in operable breast cancer: A prospective cohort study. Eur J Surg Oncol. 2018;44:444-448 pubmed publisher
    Diagnostic methods to evaluate the response to neoadjuvant chemotherapy (NAC) for breast cancer have not been established...
  50. Karimzadeh I, Khalili H, Sagheb M, Farsaei S. A double-blinded, placebo-controlled, multicenter clinical trial of N-acetylcysteine for preventing amphotericin B-induced nephrotoxicity. Expert Opin Drug Metab Toxicol. 2015;11:1345-55 pubmed publisher
    To evaluate the effectiveness of oral N-acetylcysteine (NAC) co-treatment in preventing amphotericin B (AmB)-induced nephrotoxicity (AIN), including creatinine clearance and biomarkers of renal function (cystatin C [Cys C] and kidney ..
  51. Haider A, Woodward N, Lominac K, Sacramento A, Klugmann M, Bell R, et al. Homer2 within the nucleus accumbens core bidirectionally regulates alcohol intake by both P and Wistar rats. Alcohol. 2015;49:533-42 pubmed publisher
    ..Although chronic alcohol drinking increases Homer2 expression within the core subregion of the nucleus accumbens (NAc) of alcohol-preferring P rats, the relevance of this neuroadaptation for alcohol intake has yet to be determined in ..
  52. Berrios J, Stamatakis A, Kantak P, McElligott Z, Judson M, Aita M, et al. Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation. Nat Commun. 2016;7:10702 pubmed publisher
  53. Moreira M, Irigoyen M, Saad K, Saad P, Koike M, Montero E, et al. N-acetylcysteine reduces the renal oxidative stress and apoptosis induced by hemorrhagic shock. J Surg Res. 2016;203:113-20 pubmed publisher
    ..The objective of this study was to evaluate the effect of combining N-acetylcysteine (NAC) with fluid resuscitation on renal injury in rats that underwent HS...
  54. Kim H, Hesterman J, Call T, Magazu S, Keeley E, Armenta K, et al. SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens. J Neurosci. 2016;36:8441-52 pubmed publisher
    ..stress, an ethologically validated model of depression in mice, increases SIRT1 levels in the nucleus accumbens (NAc), a key brain reward region...
  55. Jiménez Ballvé A, Pérez Castejón M, Delgado Bolton R, Sánchez Enrique C, Vilacosta I, Vivas D, et al. Assessment of the diagnostic accuracy of 18F-FDG PET/CT in prosthetic infective endocarditis and cardiac implantable electronic device infection: comparison of different interpretation criteria. Eur J Nucl Med Mol Imaging. 2016;43:2401-2412 pubmed
    ..with attenuation-correction (AC PET images); (b) visual analysis of both AC PET images and PET images without AC (NAC PET images); (c) qualitative analysis of NAC PET images; and (d) semiquantitative analysis of AC PET images...
  56. Park S, Kim S, Kim K, Yu S, Choi H, Kim Y, et al. Toyocamycin induces apoptosis via the crosstalk between reactive oxygen species and p38/ERK MAPKs signaling pathway in human prostate cancer PC-3 cells. Pharmacol Rep. 2017;69:90-96 pubmed publisher
    ..Pretreatment with N-acetyl-l-cysteine (NAC) recovered the Toyocamycin-induced mitochondrial dysfunction, ROS, and apoptosis...
  57. Keistler C, Hammarlund E, Barker J, Bond C, DiLeone R, Pittenger C, et al. Regulation of Alcohol Extinction and Cue-Induced Reinstatement by Specific Projections among Medial Prefrontal Cortex, Nucleus Accumbens, and Basolateral Amygdala. J Neurosci. 2017;37:4462-4471 pubmed publisher
    ..that the regulation of cue-guided alcohol seeking is mediated by the basolateral amygdala (BLA), nucleus accumbens (NAc), and medial prefrontal cortex (mPFC)...
  58. Zhang B, Zhang Y, Xu T, Yin Y, Huang R, Wang Y, et al. Chronic dexamethasone treatment results in hippocampal neurons injury due to activate NLRP1 inflammasome in vitro. Int Immunopharmacol. 2017;49:222-230 pubmed publisher
    ..GR antagonist, mifepristone (RU486), had protective effects on chronic DEX induced hippocampal neurons injury and NLRP1 inflammasome activation...
  59. Wu B, Tan M, Cai W, Wang B, He P, Zhang X. Arsenic trioxide induces autophagic cell death in osteosarcoma cells via the ROS-TFEB signaling pathway. Biochem Biophys Res Commun. 2018;496:167-175 pubmed publisher
    ..Importantly, ATO triggered the generation of ROS in MG-63 cells. Furthermore, NAC, an ROS scavenger, abrogated the effects of ATO on TFEB-dependent autophagic cell death...
  60. Hossain M, Saha S, Abdal Dayem A, Kim J, Kim K, Yang G, et al. Bax Inhibitor-1 Acts as an Anti-Influenza Factor by Inhibiting ROS Mediated Cell Death and Augmenting Heme-Oxygenase 1 Expression in Influenza Virus Infected Cells. Int J Mol Sci. 2018;19: pubmed publisher
    ..We found that treatment with a ROS scavenging agent, N-acetyl cysteine (NAC), led to a dramatic decrease in virus production and viral gene expression in control MDCK and BI-1 ?C-..
  61. Paydary K, Seraj S, Zadeh M, Emamzadehfard S, Shamchi S, Gholami S, et al. The Evolving Role of FDG-PET/CT in the Diagnosis, Staging, and Treatment of Breast Cancer. Mol Imaging Biol. 2019;21:1-10 pubmed publisher
    ..Numerous studies support the future role of PET/CT in prediction of response to neoadjuvant chemotherapy (NAC)...
  62. D Osualdo A, Weichenberger C, Wagner R, Godzik A, Wooley J, Reed J. CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain. PLoS ONE. 2011;6:e27396 pubmed publisher
    The "Function to Find Domain" (FIIND)-containing proteins CARD8 (Cardinal; Tucan) and NLRP1 (NALP1; NAC) are well known components of inflammasomes, multiprotein complexes responsible for activation of caspase-1, a regulator of ..
  63. Cui Y, Jia F, He J, Xie X, Li Z, Fu M, et al. Ambient Fine Particulate Matter Suppresses In Vivo Proliferation of Bone Marrow Stem Cells through Reactive Oxygen Species Formation. PLoS ONE. 2015;10:e0127309 pubmed publisher
    ..PM-induced ROS in BMSCs population, proliferation, and apotosis, experiments were repeated using N-acetylcysteine (NAC)-treated wild type mice or a triple transgenic mouse line with overexpression of antioxidant network (AON) composed ..
  64. Furfaro L, Spiller O, Keelan J, Payne M. In vitro activity of solithromycin and its metabolites, CEM-214 and N-acetyl-CEM-101, against 100 clinical Ureaplasma spp. isolates compared with azithromycin. Int J Antimicrob Agents. 2015;46:319-24 pubmed publisher
    ..metabolism varies according to species; in pregnant sheep, the bioactive metabolites CEM-214 and N-acetyl-CEM-101 (NAc-CEM-101) have been shown to accumulate in the amniotic cavity following maternal solithromycin administration, ..
  65. Esparza A, Gerdtzen Z, Olivera Nappa A, Salgado J, Núñez M. Iron-induced reactive oxygen species mediate transporter DMT1 endocytosis and iron uptake in intestinal epithelial cells. Am J Physiol Cell Physiol. 2015;309:C558-67 pubmed publisher
    ..Preincubation with the antioxidant N-acetyl-l-cysteine (NAC) resulted in increased DMT1 at the apical membrane before and after addition of iron...
  66. Allameh Z, Karimi A, Rafiei Tabatabaei S, Sharifian M, Salamzadeh J. Effect of N-acetylcysteine on inflammation biomarkers in pediatric acute pyelonephritis: a randomized controlled trial. Iran J Kidney Dis. 2015;9:454-62 pubmed
    This study was designed to investigate the effect of N-acetylcysteine (NAC), as a potent and safe antioxidant, on inflammatory biomarkers of acute pyelonephritis in pediatric patients...
  67. Santos D, Fernandes P, Guedes C, Debs Diniz A. Potential application value of Doppler ultrasonography in neoadjuvant chemotherapy for breast cancer. Minerva Ginecol. 2016;68:405-11 pubmed
    ..the vascular density by Vascularity Index (VI), to predict the pathologic response to neoadjuvant chemotherapy (NAC) for breast cancer (BC)...
  68. Okamoto A, Tanaka M, Sumi C, Oku K, Kusunoki M, Nishi K, et al. The antioxidant N-acetyl cysteine suppresses lidocaine-induced intracellular reactive oxygen species production and cell death in neuronal SH-SY5Y cells. BMC Anesthesiol. 2016;16:104 pubmed
    ..Notably, the antioxidants N-acetyl cysteine (NAC) and Trolox successfully scavenged the mitochondria-derived ROS and suppressed local lidocaine-induced cell death...
  69. Wu S. Molecular dynamics simulation study of the "stay or leave" problem for two magnesium ions in gene transcription. Proteins. 2017;85:1002-1007 pubmed publisher
    Two magnesium ions play important roles in nucleotide addition cycle (NAC) of gene transcription...
  70. Giacoppo D, Gargiulo G, Buccheri S, Aruta P, Byrne R, Cassese S, et al. Preventive Strategies for Contrast-Induced Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Procedures: Evidence From a Hierarchical Bayesian Network Meta-Analysis of 124 Trials and 28 240 Patients. Circ Cardiovasc Interv. 2017;10: pubmed publisher
    ..of 124 trials (28 240 patients) comparing a total of 10 strategies: saline, statin, N-acetylcysteine (NAC), sodium bicarbonate (NaHCO3), NAC+NaHCO3, ascorbic acid, xanthine, dopaminergic agent, ..
  71. Yang Y, Tang X, Hao F, Ma Z, Wang Y, Wang L, et al. Bavachin induces apoptosis through mitochondrial regulated ER stress pathway in HepG2 cells. Biol Pharm Bull. 2017;: pubmed publisher
    ..Additionally, suppression of reactive oxygen species (ROS) by ROS Scavenger (NAC) also reduced Bavachin-induced ER stress...
  72. Eto K, Hiki N, Kumagai K, Shoji Y, Tsuda Y, Kano Y, et al. Prophylactic effect of neoadjuvant chemotherapy in gastric cancer patients with postoperative complications. Gastric Cancer. 2018;21:703-709 pubmed publisher
    ..Recently, neoadjuvant chemotherapy (NAC) was found to improve the prognosis of advanced gastric cancer (GC)...
  73. van Verschuer V, Mureau M, Gopie J, Vos E, Verhoef C, Menke Pluijmers M, et al. Patient Satisfaction and Nipple-Areola Sensitivity After Bilateral Prophylactic Mastectomy and Immediate Implant Breast Reconstruction in a High Breast Cancer Risk Population: Nipple-Sparing Mastectomy Versus Skin-Sparing Mastectomy. Ann Plast Surg. 2016;77:145-52 pubmed publisher
    ..Skin-sparing mastectomy followed by nipple-areola complex (NAC) reconstruction is standard of care, but NSM is increasingly being performed...
  74. Klintman M, Buus R, Cheang M, Sheri A, Smith I, Dowsett M. Changes in Expression of Genes Representing Key Biologic Processes after Neoadjuvant Chemotherapy in Breast Cancer, and Prognostic Implications in Residual Disease. Clin Cancer Res. 2016;22:2405-16 pubmed publisher
    ..or against the clinical importance of several biologic processes in patients treated with neoadjuvant chemotherapy (NAC) by assessing expression of selected genes with prior implications in prognosis or treatment resistance...
  75. Muir J, Lorsch Z, Ramakrishnan C, Deisseroth K, Nestler E, Calipari E, et al. In Vivo Fiber Photometry Reveals Signature of Future Stress Susceptibility in Nucleus Accumbens. Neuropsychopharmacology. 2018;43:255-263 pubmed publisher
    ..Stress-induced alterations in the activity of reward-related brain regions, such as the nucleus accumbens (NAc), are linked to the pathophysiology of depression...
  76. Lei B, Sun S, Xu J, Feng C, Yu Y, Xu G, et al. Low-concentration BPAF- and BPF-induced cell biological effects are mediated by ROS in MCF-7 breast cancer cells. Environ Sci Pollut Res Int. 2018;25:3200-3208 pubmed publisher
    ..These biological effects were attenuated by the ROS scavenger N-acetylcysteine (NAC), indicating that ROS played a key role in the observed biological effects of BPAF and BPF on MCF-7 cells...
  77. Wu W, Deng H, Rao N, You N, Yang Y, Cao M, et al. Neoadjuvant everolimus plus letrozole versus fluorouracil, epirubicin and cyclophosphamide for ER-positive, HER2-negative breast cancer: study protocol for a randomized pilot trial. Trials. 2017;18:497 pubmed publisher
    The response to neoadjuvant chemotherapy (NAC) varies by estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) statuses, with responses being lower in ER-positive, HER2-negative tumors as compared with ER-negative, ..
  78. Liu C, Wang B, Li Z, Peng Z, Zhang J. TsNAC1 Is a Key Transcription Factor in Abiotic Stress Resistance and Growth. Plant Physiol. 2018;176:742-756 pubmed publisher
    b>NAC proteins constitute one of the largest families of plant-specific transcription factors, and a number of these proteins participate in the regulation of plant development and responses to abiotic stress. T...
  79. Spritz R, Gowan K, Bennett D, Fain P. Novel vitiligo susceptibility loci on chromosomes 7 (AIS2) and 8 (AIS3), confirmation of SLEV1 on chromosome 17, and their roles in an autoimmune diathesis. Am J Hum Genet. 2004;74:188-91 pubmed
  80. Chiu D, Jahr C. Extracellular Glutamate in the Nucleus Accumbens Is Nanomolar in Both Synaptic and Non-synaptic Compartments. Cell Rep. 2017;18:2576-2583 pubmed publisher
    ..We used electrophysiology and two-photon Ca2+ imaging to test this hypothesis in the nucleus accumbens (NAc), where it has been proposed that micromolar extracellular glutamate is necessary for normal function...
  81. Camire J, Kim D, Kwon S. Enhanced production of recombinant proteins by a small molecule protein synthesis enhancer in combination with an antioxidant in recombinant Chinese hamster ovary cells. Bioprocess Biosyst Eng. 2017;40:1049-1056 pubmed publisher
    ..4%. Additionally, supplementation of butanoic acid- and pentanoic acid-treated cultures with N-acetyl cysteine (NAC) reduced the population of cells entering early apoptosis by 5.3 and 10...
  82. Hsu S, Jan C, Liang W. Evaluation of cytotoxicity of propofol and its related mechanism in glioblastoma cells and astrocytes. Environ Toxicol. 2017;32:2440-2454 pubmed publisher
    ..by increasing O2- and H2 O2 levels but treatment with the antioxidant N-acetylcysteine (NAC) partially reversed propofol-regulated antioxidative enzyme levels (superoxide dismutase, catalase, and glutathione ..
  83. Nakagawa Y, Suzuki T, Inomata A. Preventive effects of fructose and N-acetyl-L-cysteine against cytotoxicity induced by the psychoactive compounds N-methyl-5-(2-aminopropyl)benzofuran and 3,4-methylenedioxy-N-methamphetamine in isolated rat hepatocytes. J Appl Toxicol. 2018;38:284-291 pubmed publisher
    ..dysfunction and/or oxidative stress in rat hepatocytes, the protective effects of fructose and N-acetyl-l-cysteine (NAC) on 5-MAPB- and MDMA-induced toxicity were studied in rat hepatocytes...
  84. Gregory S, Davis B, West J, Taxman D, Matsuzawa S, Reed J, et al. Discovery of a viral NLR homolog that inhibits the inflammasome. Science. 2011;331:330-4 pubmed publisher
    ..We found that KSHV Orf63 is a viral homolog of human NLRP1. Orf63 blocked NLRP1-dependent innate immune responses, including caspase-1 activation and processing of ..
  85. Levandowski C, Mailloux C, Ferrara T, Gowan K, Ben S, Jin Y, et al. NLRP1 haplotypes associated with vitiligo and autoimmunity increase interleukin-1? processing via the NLRP1 inflammasome. Proc Natl Acad Sci U S A. 2013;110:2952-6 pubmed publisher
    Nuclear localization leucine-rich-repeat protein 1 (NLRP1) is a key regulator of the innate immune system, particularly in the skin where, in response to molecular triggers such as pathogen-associated or damage-associated molecular ..
  86. Dingess P, Darling R, Derman R, Wulff S, Hunter M, Ferrario C, et al. Structural and Functional Plasticity within the Nucleus Accumbens and Prefrontal Cortex Associated with Time-Dependent Increases in Food Cue-Seeking Behavior. Neuropsychopharmacology. 2017;42:2354-2364 pubmed publisher
    ..biochemical, and DiI labeling, we examined functional and structural changes in the nucleus accumbens (NAc) and prefrontal cortex (PFC) associated with time-dependent increases in food craving ('incubation of craving')...
  87. Liang W, Jan C, Hsu S. Cytotoxic effects of gastrodin extracted from the rhizome of Gastrodia elata Blume in glioblastoma cells, but not in normal astrocytes, via the induction of oxidative stress-associated apoptosis that involved cell cycle arrest and p53 activation. Food Chem Toxicol. 2017;107:280-292 pubmed publisher
    ..Treatment with the antioxidant NAC (10 ?M) partially reversed gastrodin-altered antioxidant enzymes levels...
  88. Mett T, Krezdorn N, Luketina R, Boyce M, Henseler H, Ipaktchi R, et al. Optimal Positioning of the Nipple-Areola Complex in Men Using the Mohrenheim-Estimated-Tangential-Tracking-Line (METT-Line): An Intuitive Approach. Aesthetic Plast Surg. 2017;41:1295-1302 pubmed publisher
    ..In particular, the positions of the nipple-areola complexes (NAC) should contribute to the gender-appropriate appearance...
  89. Bernstein D, Badve P, Barson J, Bass C, Espana R. Hypocretin receptor 1 knockdown in the ventral tegmental area attenuates mesolimbic dopamine signaling and reduces motivation for cocaine. Addict Biol. 2018;23:1032-1045 pubmed publisher
    ..examined the effects of HCRTr1 knockdown on cocaine self-administration and DA signaling in the nucleus accumbens (NAc) core...
  90. Fahy R, Exline M, Gavrilin M, Bhatt N, BESECKER B, Sarkar A, et al. Inflammasome mRNA expression in human monocytes during early septic shock. Am J Respir Crit Care Med. 2008;177:983-8 pubmed publisher
    ..Relative copy numbers for the inflammasome mRNAs for ASC, caspase-1, NALP1, and Pypaf-7 were significantly lower in patients with septic shock compared with critically ill control subjects...
  91. Lu B, Nakamura T, Inouye K, Li J, Tang Y, Lundbäck P, et al. Novel role of PKR in inflammasome activation and HMGB1 release. Nature. 2012;488:670-4 pubmed publisher
    ..with several inflammasome components, including NOD-like receptor (NLR) family pyrin domain-containing 3 (NLRP3), NLRP1, NLR family CARD domain-containing protein 4 (NLRC4), absent in melanoma 2 (AIM2), and broadly regulates ..
  92. Hosogoe S, Hatakeyama S, Kusaka A, Hamano I, Iwamura H, Fujita N, et al. Platinum-based Neoadjuvant Chemotherapy Improves Oncological Outcomes in Patients with Locally Advanced Upper Tract Urothelial Carcinoma. Eur Urol Focus. 2018;4:946-953 pubmed publisher
    Neoadjuvant chemotherapy (NAC) use for patients with locally advanced upper tract urothelial carcinoma (UTUC) is debatable. To investigate the efficacy and safety of platinum-based NAC for locally advanced UTUC...