NLRC5

Summary

Gene Symbol: NLRC5
Description: NLR family CARD domain containing 5
Alias: CLR16.1, NOD27, NOD4, protein NLRC5, NOD-like receptor C5, caterpiller protein 16.1, nucleotide-binding oligomerization domain protein 4, nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5, nucleotide-binding oligomerization domains 27
Species: human
Products:     NLRC5

Top Publications

  1. Meissner T, Li A, Liu Y, Gagnon E, Kobayashi K. The nucleotide-binding domain of NLRC5 is critical for nuclear import and transactivation activity. Biochem Biophys Res Commun. 2012;418:786-91 pubmed publisher
    ..A member of the NLR (nucleotide-binding domain, leucine-rich repeat) protein family, NLRC5, has recently been identified as a transcriptional regulator of MHC class I and related genes...
  2. Cui J, Zhu L, Xia X, Wang H, Legras X, Hong J, et al. NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell. 2010;141:483-96 pubmed publisher
    ..Here, we show that NLRC5, a member of the highly conserved NOD-like protein family, can inhibit the IKK complex and RIG-I/MDA5 function...
  3. Neerincx A, Lautz K, Menning M, Kremmer E, Zigrino P, Hösel M, et al. A role for the human nucleotide-binding domain, leucine-rich repeat-containing family member NLRC5 in antiviral responses. J Biol Chem. 2010;285:26223-32 pubmed publisher
    ..Here we report on the characterization of human NLRC5 and provide evidence that this NLR has a function in innate immune responses...
  4. Kuenzel S, Till A, Winkler M, Häsler R, Lipinski S, Jung S, et al. The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses. J Immunol. 2010;184:1990-2000 pubmed publisher
    ..This report describes the genomic organization and regulation of the human NLR family member NLRC5 and aspects of cellular function of the encoded protein...
  5. Benko S, Magalhaes J, Philpott D, Girardin S. NLRC5 limits the activation of inflammatory pathways. J Immunol. 2010;185:1681-91 pubmed publisher
    ..In this study, we present the identification and characterization of NLRC5, a NLR protein whose expression is found predominantly in cells of the myeloid and lymphoid lineages...
  6. Lamkanfi M, Kanneganti T. Regulation of immune pathways by the NOD-like receptor NLRC5. Immunobiology. 2012;217:13-6 pubmed publisher
    ..The NLR family member NLRC5 was recently proposed to function as a positive and negative regulator of antiviral immune responses...
  7. Periyasamy P, Thangaraj A, Bendi V, Buch S. HIV-1 Tat-mediated microglial inflammation involves a novel miRNA-34a-NLRC5-NFκB signaling axis. Brain Behav Immun. 2019;: pubmed publisher
    ..Tat resulted both in a dose- and time-dependent upregulation of miRNA-34a, with concomitant downregulation of NLRC5 (a negative regulator of NFκB signaling) expression...
  8. Kang Y, Biswas A, Field M, Snapper S. STAT1 signaling shields T cells from NK cell-mediated cytotoxicity. Nat Commun. 2019;10:912 pubmed publisher
    ..Mechanistically, Stat1-/- T cells have reduced expression of Nlrc5 and multiple MHC class I molecules that serve to protect cells from NK cell-mediated killing...
  9. Wu Y, Shi T, Li J. NLRC5: A paradigm for NLRs in immunological and inflammatory reaction. Cancer Lett. 2019;451:92-99 pubmed publisher
    ..b>NLRC5, the largest member of the NLR family, is currently receiving an increasing level of attention...

More Information

Publications90

  1. Ding Z, Zhao X, Cui L, Sun Q, Zhang F, Wang J, et al. Novel insights into the immune regulatory effects of ferritins from blunt snout bream, Megalobrama amblycephala. Fish Shellfish Immunol. 2019;87:679-687 pubmed publisher
    ..The results showed that NLRC5 (NOD-like Receptor Family CARD Domain Containing 5) mediated the regulation of MamFers on expression of MHC I (..
  2. Vijayan S, Sidiq T, Yousuf S, van den Elsen P, Kobayashi K. Class I transactivator, NLRC5: a central player in the MHC class I pathway and cancer immune surveillance. Immunogenetics. 2019;71:273-282 pubmed publisher
    ..Recently, another NLR protein, NLRC5 (NLR family, CARD domain-containing 5), was identified as an MHC class I transactivator (CITA)...
  3. Wang Q, Ding H, He Y, Li X, Cheng Y, Xu Q, et al. NLRC5 mediates cell proliferation, migration, and invasion by regulating the Wnt/β-catenin signalling pathway in clear cell renal cell carcinoma. Cancer Lett. 2019;444:9-19 pubmed publisher
    b>NLRC5, a newly discovered member of the NLR family, has been reported to regulate immune responses and promote cell proliferation, migration, and invasion in hepatocellular carcinoma...
  4. Hosseinzadeh N, Mehrabi Y, Daneshpour M, Zayeri F, Guity K, Azizi F. Identifying new associated pleiotropic SNPs with lipids by simultaneous test of multiple longitudinal traits: An Iranian family-based study. Gene. 2019;692:156-169 pubmed publisher
    ..Twenty variants within the AC009035.1, SLC12A3, CETP, NLRC5, ESRP2 and, C16orf95 genes showed strong evidence for association with HDL-C, cholesterol, and triglycerides with ..
  5. Rodino K, Adcox H, Martin R, Patel V, Conrad D, Carlyon J. The Obligate Intracellular Bacterium Orientia tsutsugamushi Targets NLRC5 To Modulate the Major Histocompatibility Complex Class I Pathway. Infect Immun. 2019;87: pubmed publisher
    ..tsutsugamushi reduces cellular levels of NOD-, LRR-, and CARD-containing 5 (NLRC5), a recently identified specific transactivator of major histocompatibility complex class I (MHC-I) component gene ..
  6. Chen Y, Li H, Xiao C, Zeng X, Xiao X, Zhou Q, et al. NLRC5: potential novel non-invasive biomarker for predicting and reflecting the progression of IgA nephritis. J Transl Med. 2018;16:317 pubmed publisher
    The nucleotide oligomerization domain-like receptor subfamily C5 (NLRC5) is primarily expressed in the adaptive and innate immune systems. NLRC5 was recently discovered to regulate immunity and inflammatory responses...
  7. Zhan L, Yao S, Sun S, Su Q, Li J, Wei B. NLRC5 and autophagy combined as possible predictors in patients with endometriosis. Fertil Steril. 2018;110:949-956 pubmed publisher
    To investigate the levels of NLRC5 and autophagy in women with leiomyoma and endometriosis and the correlation between NLRC5 level and autophagy level. Case-control study. Clinics...
  8. Martinez D, Vargas Lagos C, Oyarzun R, Loncoman C, Pontigo J, Yañez A, et al. Temperature modulates the immunological response of the sub-antarctic notothenioid fish Eleginops maclovinus injected with Piscirickettsia salmonis. Fish Shellfish Immunol. 2018;82:492-503 pubmed publisher
    ..Expression of the mRNA related with the innate immune response gene (TLR1, TLR5, TLR8, NLRC3, NLRC5, MyD88 and IL-1β) as well as the adaptive immune response gene (MHCI, MHCII, IgMs and IgD) were measured in ..
  9. Marth C, Firestone S, Hanlon D, Glenton L, Browning G, Young N, et al. Innate immune genes in persistent mating-induced endometritis in horses. Reprod Fertil Dev. 2018;30:533-545 pubmed publisher
    ..Genes for pathogen recognition receptors Toll-like receptor 2 (TLR2) and NLR family CARD domain containing 5 (NLRC5), as well as tissue-specific inhibitor of metalloproteinase 1 (TIMP1), C-X-C motif chemokine ligand (CXCL) 9, ..
  10. Angstetra E, Graham K, Emmett S, Dudek N, Darwiche R, Ayala Perez R, et al. In vivo effects of cytokines on pancreatic beta-cells in models of type I diabetes dependent on CD4(+) T lymphocytes. Immunol Cell Biol. 2009;87:178-85 pubmed publisher
    ..investigated the direct effects of cytokines on beta-cells in perforin-deficient non-obese diabetic (NOD) mice and NOD4.1 TCR transgenic mice, two models in which CD8(+) T cells play a less dominant role...
  11. Rota G, Ludigs K, Siegert S, Tardivel A, Morgado L, Reith W, et al. T Cell Priming by Activated Nlrc5-Deficient Dendritic Cells Is Unaffected despite Partially Reduced MHC Class I Levels. J Immunol. 2016;196:2939-46 pubmed publisher
    b>NLRC5, a member of the NOD-like receptor (NLR) protein family, has recently been characterized as the master transcriptional regulator of MHCI molecules in lymphocytes, in which it is highly expressed...
  12. Braga C, Bittarello A, Padilha C, Leite A, Moraes P, Buzalaf M, et al. Mercury fractionation in dourada (Brachyplatystoma rousseauxii) of the Madeira River in Brazil using metalloproteomic strategies. Talanta. 2015;132:239-44 pubmed publisher
    ..The ESI-MS/MS analysis allowed characterisation of the seven protein spots as the following proteins: protein NLRC5 (molar mass=18.10, pI=6.30); 39S ribosomal protein L36 mitochondrial (molar mass=15.40, pI=8...
  13. Meldrum K, Robertson S, Römer I, Marczylo T, Dean L, Rogers A, et al. Cerium dioxide nanoparticles exacerbate house dust mite induced type II airway inflammation. Part Fibre Toxicol. 2018;15:24 pubmed publisher
    ..Changes in the expression of genes including CCL20, CXCL10, NLRC5, IRF7 and CLEC10A suggest regulation of dendritic cells, macrophage functionality and IRF3 modulation as key early ..
  14. Ludigs K, Seguín Estévez Q, Lemeille S, Ferrero I, Rota G, Chelbi S, et al. NLRC5 exclusively transactivates MHC class I and related genes through a distinctive SXY module. PLoS Genet. 2015;11:e1005088 pubmed publisher
    ..b>NLRC5, another NLR protein, was recently found to control transcription of MHC class I (MHCI) genes...
  15. Li Q, Wang Z, Zhang Y, Zhu J, Li L, Wang X, et al. NLRC5 deficiency protects against acute kidney injury in mice by mediating carcinoembryonic antigen-related cell adhesion molecule 1 signaling. Kidney Int. 2018;94:551-566 pubmed publisher
    There is significant progress in understanding the structure and function of NLRC5, a member of the nucleotide oligomerization domain-like receptor family...
  16. Cao L, Wu X, Hu Y, Xue N, Nie P, Chang M. The discrepancy function of NLRC5 isoforms in antiviral and antibacterial immune responses. Dev Comp Immunol. 2018;84:153-163 pubmed publisher
    ..b>NLRC5, the largest member of NLR family, has been characterized as a regulator of innate immunity and MHC class I ..
  17. Han F, Gao Y, Ding C, Xia X, Wang Y, Xue W, et al. Knockdown of NLRC5 attenuates renal I/R injury in vitro through the activation of PI3K/Akt signaling pathway. Biomed Pharmacother. 2018;103:222-227 pubmed publisher
    b>NLRC5, as the largest member of nucleotide-binding domain and leucine-rich repeat (NLR) family, was involved in various physiological processes, such as inflammation, fibrosis, innate immunity and diabetic nephropathy...
  18. Qiu L, Xu L, Guo X, Li Z, Wan F, Liu X, et al. Gene expression changes in chicken NLRC5 signal pathway associated with in vitro avian leukosis virus subgroup J infection. Genet Mol Res. 2016;15: pubmed publisher
    ..However, the role of NLRC5, which is a member of the NLR family, in NF-?B activation and MHC-I expression remains debatable...
  19. Carretero F, Del Campo A, Flores Martín J, Mendez R, García Lopez C, Cozar J, et al. Frequent HLA class I alterations in human prostate cancer: molecular mechanisms and clinical relevance. Cancer Immunol Immunother. 2016;65:47-59 pubmed publisher
    ..Molecular analysis revealed a reduced expression of B2M, TAP2, tapasin and NLRC5 mRNA in microdissected HLA-I-negative tumors...
  20. Holloway G, Fleming F, Coulson B. MHC class I expression in intestinal cells is reduced by rotavirus infection and increased in bystander cells lacking rotavirus antigen. Sci Rep. 2018;8:67 pubmed publisher
    ..STAT1 activation by interferon can induce NLRC5 expression, promoting MHCI expression...
  21. Zeng Q, Chen X, Ning C, Zhu Q, Yao Y, Zhao Y, et al. Methylation of the genes ROD1, NLRC5, and HKR1 is associated with aging in Hainan centenarians. BMC Med Genomics. 2018;11:7 pubmed publisher
    ..It was also found that hypermethylation of HKR1 and hypomethylation of ROD1 and NLRC5 genes strongly correlated with age in centenarians...
  22. Sinha D, Ghosh A, Mukherjee S, Biswas R, Biswas T. Porin differentiates TLR mediated proinflammatory response of follicular zone B cell from TLR-unresponsive IL-10 expressing marginal zone B cell. Cytokine. 2015;76:193-205 pubmed publisher
    ..of the intracellular pathogen recognition receptor NLR caspase recruitment domain containing protein 5 (NLRC5). The CD1d(hi) MZ B cells released IL-10 unequivocally demonstrating regulatory B cell feature...
  23. Ludigs K, Jandus C, Utzschneider D, Staehli F, Bessoles S, Dang A, et al. NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions. Nat Commun. 2016;7:10554 pubmed publisher
    b>NLRC5 is a transcriptional regulator of MHC class I (MHCI), which maintains high MHCI expression particularly in T cells...
  24. Marth C, Firestone S, Glenton L, Browning G, Young N, Krekeler N. Oestrous cycle-dependent equine uterine immune response to induced infectious endometritis. Vet Res. 2016;47:110 pubmed
    ..The concentrations of mRNAs for Toll-like receptor (TLR)2, TLR4, NOD-like receptor NLRC5, tissue inhibitor of metallopeptidases 1 (TIMP1) and chemokines CCL2, CXCL9, CXCL10 and CXCL11 were all increased ..
  25. Yoshihama S, Vijayan S, Sidiq T, Kobayashi K. NLRC5/CITA: A Key Player in Cancer Immune Surveillance. Trends Cancer. 2017;3:28-38 pubmed publisher
    ..MHC class I transactivator (CITA), NLRC5 [nucleotide-binding domain and leucine-rich repeats containing (NLR) family, caspase activation and recruitment ..
  26. Chelbi S, Dang A, Guarda G. Emerging Major Histocompatibility Complex Class I-Related Functions of NLRC5. Adv Immunol. 2017;133:89-119 pubmed publisher
    ..demonstrates a key role for the nucleotide-binding oligomerization domain-like receptor (NLR) family member NLRC5 (NLR family, CARD domain containing protein 5) in the transcriptional regulation of major histocompatibility ..
  27. Marth C, Young N, Glenton L, Noden D, Browning G, Krekeler N. Deep sequencing of the uterine immune response to bacteria during the equine oestrous cycle. BMC Genomics. 2015;16:934 pubmed publisher
    ..These include pathogen recognition receptors, particularly toll-like receptors TLR2 and 4 and NOD-like receptor NLRC5. In addition, several interleukins including IL1B, IL6, IL8 and IL1ra were significantly up-regulated...
  28. Pontigo J, Agüero M, Sánchez P, Oyarzún R, Vargas Lagos C, Mancilla J, et al. Identification and expressional analysis of NLRC5 inflammasome gene in smolting Atlantic salmon (Salmo salar). Fish Shellfish Immunol. 2016;58:259-265 pubmed publisher
    ..Therefore, this study analyzed the Atlantic salmon (Salmo salar) NLRC5. Structurally, Atlantic salmon NLRC5 presented leucine-rich repeat subfamily genes...
  29. Agudo J, Park E, Rose S, Alibo E, Sweeney R, Dhainaut M, et al. Quiescent Tissue Stem Cells Evade Immune Surveillance. Immunity. 2018;48:271-285.e5 pubmed publisher
    ..the antigen presentation machinery, including MHC class I and TAP proteins, and is mediated by the transactivator NLRC5. This process was reversed upon stem cell entry into the cell cycle...
  30. Zhang X, Hu Y, Justice A, Li B, Wang Z, Zhao H, et al. DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailty. Nat Commun. 2017;8:2243 pubmed publisher
    ..We observe 6 significant CpGs in the promoters of 4 genes, NLRC5, TRIM69, CX3CR1, and BCL9, in the discovery sample and in meta-analysis...
  31. Wang S, Zhao X, Yang S, Chen B, Shi J. Knockdown of NLRC5 inhibits renal fibroblast activation via modulating TGF-β1/Smad signaling pathway. Eur J Pharmacol. 2018;829:38-43 pubmed publisher
    b>NLRC5, the largest member of the Nucleotide-binding domain and leucine-rich repeat (NLR) protein family, is recently proven to be a critical modulator in fibrogenesis. However, the role of NLRC5 in renal fibrosis remains unknown...
  32. Li J, Kong L, Gao Y, Wu C, Xu T. Characterization of NLR-A subfamily members in miiuy croaker and comparative genomics revealed NLRX1 underwent duplication and lose in actinopterygii. Fish Shellfish Immunol. 2015;47:397-406 pubmed publisher
    ..Here we analyzed three NLR-A subfamily members from miiuy croaker: NLRC3, NLRC5, and NLRX1...
  33. Richardson S, Rodríguez Calvo T, Gerling I, Mathews C, Kaddis J, Russell M, et al. Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes. Diabetologia. 2016;59:2448-2458 pubmed publisher
    ..class I isoforms, signal transducer and activator of transcription 1 (STAT1), NLR family CARD domain containing 5 (NLRC5) and islet hormones...
  34. Liu R, Truax A, Chen L, Hu P, Li Z, Chen J, et al. Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: correlation with cancer stages and inflammasome components. Oncotarget. 2015;6:33456-69 pubmed publisher
    ..Genes analyzed include NLRP1, NLRP3, NLRP6, NLRP12, NLRC3, NLRC4, NLRC5, NOD1, NOD2 and AIM2...
  35. Ma S, Xie X. NLRC5 deficiency promotes myocardial damage induced by high fat diet in mice through activating TLR4/NF-κB. Biomed Pharmacother. 2017;91:755-766 pubmed publisher
    ..The NOD-like protein family member, NLRC5, could interact with IKKα to inhibit IKK complex activation...
  36. Yang Q, Chen T, Chen Y, Lan D. Molecular characterization and expression analysis of the NLR family CARD containing five transcripts in the pig. Pol J Vet Sci. 2016;19:753-761 pubmed publisher
    The NOD-like receptor (NLR) family caspase recruitment domain-containing 5 (NLRC5) is one of the newly discovered and largest NLR family members...
  37. Liu X, Wu Y, Yang Y, Li W, Huang C, Meng X, et al. Role of NLRC5 in progression and reversal of hepatic fibrosis. Toxicol Appl Pharmacol. 2016;294:43-53 pubmed publisher
    b>NLRC5, as the largest member of NLRs family, has recently been identified as a critical regulator of immune responses through negatively regulating NF-κB which is associated with the development of hepatic fibrosis...
  38. Qiu L, Ma T, Chang G, Liu X, Guo X, Xu L, et al. Expression patterns of NLRC5 and key genes in the STAT1 pathway following infection with Salmonella pullorum. Gene. 2017;597:23-29 pubmed publisher
    b>NLRC5, a protein belonging to the NOD-like receptor protein family (NLRs), is highly expressed in immune tissues and cells...
  39. Yeung K, Chung B, Choufani S, Mok M, Wong W, Mak C, et al. Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway. PLoS ONE. 2017;12:e0169553 pubmed publisher
    ..and 100 healthy controls by performing bisulfite pyrosequencing of four hypomethylated genes, MX1, IFI44L, NLRC5 and PLSCR1. In addition, loss of DNA methylation in these genes was associated with an increase in mRNA expression...
  40. Lupfer C, Stokes K, Kuriakose T, Kanneganti T. Deficiency of the NOD-Like Receptor NLRC5 Results in Decreased CD8+ T Cell Function and Impaired Viral Clearance. J Virol. 2017;91: pubmed publisher
    ..The NLR family member NLRC5 regulates major histocompatibility complex class I (MHC-I) expression during various types of infections, but its ..
  41. Nyúl Tóth Ã, Kozma M, NagyÅ‘szi P, Nagy K, Fazakas C, Haskó J, et al. Expression of pattern recognition receptors and activation of the non-canonical inflammasome pathway in brain pericytes. Brain Behav Immun. 2017;64:220-231 pubmed publisher
    ..We detected expression of NOD1, NOD2, NLRC5, NLRP1-3, NLRP5, NLRP9, NLRP10 and NLRX mRNA in non-treated cells...
  42. NagyÅ‘szi P, Nyúl Tóth Ã, Fazakas C, Wilhelm I, Kozma M, Molnár J, et al. Regulation of NOD-like receptors and inflammasome activation in cerebral endothelial cells. J Neurochem. 2015;135:551-64 pubmed publisher
    ..First we detected the expression of several NOD-like receptors (NLRs) - including NOD1, NOD2, NLRC4, NLRC5, NLRP1, NLRP3, NLRP5, NLRP9, NLRP10, NLRP12, NLRA, and NLRX - in human brain endothelial cells...
  43. Chang G, Liu X, Ma T, Xu L, Wang H, Li Z, et al. A mutation in the NLRC5 promoter limits NF-κB signaling after Salmonella Enteritidis infection in the spleen of young chickens. Gene. 2015;568:117-23 pubmed publisher
    To date, the functions of the NLRC5 in chickens remain undefined. In the current study, chicken NLRC5 was cloned and an A1017G mutation was detected in its promoter region...
  44. Hu Y. A feedforward loop of NLRC5 (de)ubiquitination keeps IKK-NF-κB in check. J Cell Biol. 2015;211:941-3 pubmed publisher
    ..2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201505091) reveal that the IKK regulator NLRC5 shapes NF-κB activity through a feedforward loop of NLRC5 ubiquitination and deubiquitination, highlighting a ..
  45. Zhou H, Yu X, Zhou G. NLRC5 silencing ameliorates cardiac fibrosis by inhibiting the TGF‑β1/Smad3 signaling pathway. Mol Med Rep. 2017;16:3551-3556 pubmed publisher
    ..As the largest member of the nucleotide‑binding domain and leucine‑rich repeat (NLR) family, NLRC5 has been shown to be pivotal in the development of hepatic fibrosis...
  46. Lin X, Peng C, Greenbaum J, Li Z, Wu K, Ao Z, et al. Identifying potentially common genes between dyslipidemia and osteoporosis using novel analytical approaches. Mol Genet Genomics. 2018;293:711-723 pubmed publisher
    ..Three SNPs (rs2178950, rs9939318, and rs9368716) might be the pleiotropic ones and the corresponding genes NLRC5 (rs2178950) and TRPS1 (rs9939318) were involved in NF-?B signaling pathway and Wnt signaling pathway as well as ..
  47. Alvarez C, Ramírez Cepeda F, Santana P, Torres E, Cortes J, Guzman F, et al. Insights into the diversity of NOD-like receptors: Identification and expression analysis of NLRC3, NLRC5 and NLRX1 in rainbow trout. Mol Immunol. 2017;87:102-113 pubmed publisher
    ..Future studies will focus on gills which could be related with a key sensor mucosal system in one of the most environmentally fish exposed tissues. ..
  48. Guo X, Liu X, Chang G, Xu L, Bi Y, Wang H, et al. Characterization of the NLRC5 promoter in chicken: SNPs, regulatory elements and CpG islands. Anim Genet. 2016;47:579-87 pubmed publisher
    b>NLRC5 plays an important role in the innate immunity and cellular immunity in many species, but the regulatory mechanism of NLRC5 expression in chickens remains unclear...
  49. Liu Y, Yan X, Yu H, Yao Y, Wang J, Li X, et al. NLRC5 promotes cell proliferation via regulating the NF-?B signaling pathway in Rheumatoid arthritis. Mol Immunol. 2017;91:24-34 pubmed publisher
    ..We used complete Freund's adjuvant (CFA) induced rats as animal models for studying the RA pathogenesis. NLRC5 as the largest member of the NLR family has been reported to play a critical role in regulating immune responses...
  50. Luan P, Zhuang J, Zou J, Li H, Shuai P, Xu X, et al. NLRC5 deficiency ameliorates diabetic nephropathy through alleviating inflammation. FASEB J. 2018;32:1070-1084 pubmed publisher
    NOD-like receptor family caspase recruitment domain family domain containing 5 (NLRC5) has important roles in inflammation and innate immunity...
  51. Davis B, Roberts R, Huang M, Willingham S, Conti B, Brickey W, et al. Cutting edge: NLRC5-dependent activation of the inflammasome. J Immunol. 2011;186:1333-7 pubmed publisher
    ..b>NLRC5 is predominantly expressed in hematopoietic cells and has not been studied for inflammasome function...
  52. Dowds T, Masumoto J, Chen F, Ogura Y, Inohara N, Nunez G. Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product. Biochem Biophys Res Commun. 2003;302:575-80 pubmed
    ..These results provide evidence for a cryopyrin signaling pathway activated through the induced proximity of ASC, which is negatively regulated by pyrin. ..
  53. Xu T, Ni M, Huang C, Meng X, He Y, Zhang L, et al. NLRC5 Mediates IL-6 and IL-1β Secretion in LX-2 Cells and Modulated by the NF-κB/Smad3 Pathway. Inflammation. 2015;38:1794-804 pubmed publisher
    ..b>NLRC5 (NLR family, CARD domain containing 5) is the largest member of the NLR family, which has recently been identified ..
  54. Wu X, Hu Y, Xue N, Ren S, Chen S, Nie P, et al. Role of zebrafish NLRC5 in antiviral response and transcriptional regulation of MHC related genes. Dev Comp Immunol. 2017;68:58-68 pubmed publisher
    ..Although the NLR family member NLRC5 is functionally defined, the role of NLRC5 in regulating innate immune signaling has been controversial in mammals,..
  55. Ranjan P, Singh N, Kumar A, Neerincx A, Kremmer E, Cao W, et al. NLRC5 interacts with RIG-I to induce a robust antiviral response against influenza virus infection. Eur J Immunol. 2015;45:758-72 pubmed publisher
    The NLR protein, NLRC5 is an important regulator of MHC class I gene expression, however, the role of NLRC5 in other innate immune responses is less well defined...
  56. Thanasaksiri K, Hirono I, Kondo H. Molecular cloning and expression analysis of NOD-like receptor 5 in Japanese flounder (Paralichthys olivaceus) after injection with two different formalin-killed pathogenic bacteria and poly (I:C). Dev Comp Immunol. 2017;67:481-484 pubmed publisher
    ..Here, we identified a type of NLR with a CARD domain (NLRC5) in Japanese flounder, Paralichthys olivaceus (JfNLRC5)...
  57. Xu T, Ni M, Xing Li -, Li X, Meng X, Huang C, et al. NLRC5 regulates TGF-β1-induced proliferation and activation of hepatic stellate cells during hepatic fibrosis. Int J Biochem Cell Biol. 2016;70:92-104 pubmed publisher
    ..b>NLRC5, the largest member of the NLR protein family, has recently been identified as a critical regulator of immune ..
  58. Staehli F, Ludigs K, Heinz L, Seguín Estévez Q, Ferrero I, Braun M, et al. NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells. J Immunol. 2012;188:3820-8 pubmed publisher
    ..The function of the family member NLR caspase recruitment domain containing protein 5 (NLRC5) remains a matter of debate, particularly with respect to NF-?B activation, type I IFN, and MHC I expression...
  59. Janowski A, Sutterwala F. Atypical Inflammasomes. Methods Mol Biol. 2016;1417:45-62 pubmed publisher
    ..NLRP1, NLRP3, NLRC4, and AIM2, which form well-described inflammasome complexes, IFI16, NLRP6, NLRP7, NLRP12, and NLRC5 have also been proposed to form inflammasomes under specific conditions...
  60. Li J, Yu L, Shen Z, Li Y, Chen B, Wei W, et al. miR-34a and its novel target, NLRC5, are associated with HPV16 persistence. Infect Genet Evol. 2016;44:293-299 pubmed publisher
    ..Through bioinformatics analysis and dual-luciferase assay with site-directed mutagenesis strategy, NLRC5, a negative regulator of NF-κB signaling, was identified to be a novel interactor of miR-34a...
  61. Chen Z, Ding T, Ma C. Dexmedetomidine (DEX) protects against hepatic ischemia/reperfusion (I/R) injury by suppressing inflammation and oxidative stress in NLRC5 deficient mice. Biochem Biophys Res Commun. 2017;493:1143-1150 pubmed publisher
    ..No specific therapeutic strategies are available to attenuate I/R injury. NOD-, LRR-and CARD-containing 5 (NLRC5), a member of the NOD-like protein family, has been suggested to negatively regulate nuclear factor kappa B (NF-?B)..
  62. Ma H, Zhao X, Chen G, Fang R, Zhang F. Silencing NLRC5 inhibits extracellular matrix expression in keloid fibroblasts via inhibition of transforming growth factor-?1/Smad signaling pathway. Biomed Pharmacother. 2016;83:1016-1021 pubmed publisher
    Dermal fibrosis is characterized by collagen accumulation and hyperproliferation of fibroblasts. NLRC5, as the largest member of nucleotide-binding domain and leucine-rich repeat (NLRs) family, has recently been implicated in the ..
  63. Jongsma M, Guarda G, Spaapen R. The regulatory network behind MHC class I expression. Mol Immunol. 2017;: pubmed publisher
    ..The identification of NLRC5 as regulator of MHC class I transcription was a huge step forward in understanding the transcriptional mechanism ..
  64. Catalano C, da Silva Filho M, Frank C, Jiraskova K, Vymetalkova V, Levy M, et al. Investigation of single and synergic effects of NLRC5 and PD-L1 variants on the risk of colorectal cancer. PLoS ONE. 2018;13:e0192385 pubmed publisher
    ..has been reported in colorectal cancer (CRC), leading to a strong CD8+ T cell response through stimulation of NLRC5 expression. Primed CD8+ T cell expansion, however, may be negatively regulated by PD-L1 expression...
  65. Guo X, Liu T, Shi H, Wang J, Ji P, Wang H, et al. Respiratory Syncytial Virus Infection Upregulates NLRC5 and Major Histocompatibility Complex Class I Expression through RIG-I Induction in Airway Epithelial Cells. J Virol. 2015;89:7636-45 pubmed publisher
    ..RSV infection upregulates major histocompatibility complex class I (MHC-I) expression through the induction of NLRC5, a NOD-like, CARD domain-containing intracellular protein that has recently been identified as a class I MHC ..
  66. He Y, Li M, Zhang X, Meng X, Huang C, Li J. NLRC5 promotes cell proliferation via regulating the AKT/VEGF-A signaling pathway in hepatocellular carcinoma. Toxicology. 2016;359-360:47-57 pubmed publisher
    b>NLRC5, a newly found member of the NLR family and the largest member of nucleotide-binding, has been reported to regulate immune responses and is associated with hepatocellular carcinoma (HCC)...
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    ..Here, we identify another member of the NLR protein family, NLRC5, as a transcriptional regulator of MHC class I genes...
  68. Gutte P, Jurt S, Grutter M, Zerbe O. Unusual structural features revealed by the solution NMR structure of the NLRC5 caspase recruitment domain. Biochemistry. 2014;53:3106-17 pubmed publisher
    ..b>NLRC5 contains an unclassified N-terminal effector domain that has been reported to interact downstream with the tandem ..
  69. Meissner T, Liu Y, Lee K, Li A, Biswas A, van Eggermond M, et al. NLRC5 cooperates with the RFX transcription factor complex to induce MHC class I gene expression. J Immunol. 2012;188:4951-8 pubmed publisher
    ..A member of the nucleotide-binding domain, leucine-rich repeat (NLR) protein family, NLRC5, is a newly identified transcriptional regulator of MHC class I genes...
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    b>NLRC5 is an important regulator in innate immune responses. However, the ability of NLRC5 to inhibit NF-κB activation is controversial in different cell types. How dynamic modification of NLRC5 shapes NF-κB signaling remains unknown...
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    ..Recently identified MHC class I transactivator (CITA), or NLRC5, also belongs to the NLR protein family and constitutes a critical regulator for the transcriptional activation of ..
  72. Yoshihama S, Roszik J, Downs I, Meissner T, Vijayan S, Chapuy B, et al. NLRC5/MHC class I transactivator is a target for immune evasion in cancer. Proc Natl Acad Sci U S A. 2016;113:5999-6004 pubmed publisher
    ..MHC class I transactivator (CITA), known as "NLRC5" [NOD-like receptor (NLR) family, caspase recruitment (CARD) domain containing 5], has recently been identified as ..
  73. Kobayashi K, van den Elsen P. NLRC5: a key regulator of MHC class I-dependent immune responses. Nat Rev Immunol. 2012;12:813-20 pubmed publisher
    ..NOD-, LRR- and CARD-containing 5 (NLRC5) was recently identified as a specific transactivator of MHC class I genes (CITA)...
  74. Fanous A, Zhou B, Aggen S, Bergen S, Amdur R, Duan J, et al. Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms. Am J Psychiatry. 2012;169:1309-17 pubmed publisher
    ..The polygenic signal that has been observed in cross-sample analyses of schizophrenia GWAS data sets could be in part related to genetic effects on negative and disorganized symptoms (i.e., core features of chronic schizophrenia). ..
  75. Neerincx A, Rodriguez G, Steimle V, Kufer T. NLRC5 controls basal MHC class I gene expression in an MHC enhanceosome-dependent manner. J Immunol. 2012;188:4940-50 pubmed publisher
    ..In this article, we report that human NLRC5, which we recently showed to be involved in viral-mediated type I IFN responses, shuttles to the nucleus and ..
  76. Peng Y, He Y, Chen C, Xu T, Li L, Ni M, et al. NLRC5 regulates cell proliferation, migration and invasion in hepatocellular carcinoma by targeting the Wnt/β-catenin signaling pathway. Cancer Lett. 2016;376:10-21 pubmed publisher
    b>NLRC5, the largest member of nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR) family, has been reported to regulate immune responses and is associated with chronic inflammatory diseases...
  77. Triantafilou K, Kar S, van Kuppeveld F, Triantafilou M. Rhinovirus-induced calcium flux triggers NLRP3 and NLRC5 activation in bronchial cells. Am J Respir Cell Mol Biol. 2013;49:923-34 pubmed publisher
    ..domain-like receptors (NLRs), we show that the rhinovirus ion channel protein 2B triggers NLRP3 and NLRC5 inflammasome activation and IL-1? secretion in bronchial cells...
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    ..The NOD-like receptor family CARD domain containing 5 (NLRC5) is the largest member of this family that also contains the largest number of leucine-rich repeats (LRRs)...
  79. Zhou Z, Wu Y, Zhang C, Li C, Chen G, Yu X, et al. Suppression of NF-?B signal pathway by NLRC3-like protein in stony coral Acropora aculeus under heat stress. Fish Shellfish Immunol. 2017;67:322-330 pubmed publisher
    ..protein, 5 nucleotide-binding oligomerization domain-containing protein, 29 NLRC3-like protein, 4 NLRC5-like protein, and 3 uncharacterized protein...
  80. Neerincx A, Jakobshagen K, Utermöhlen O, Buning H, Steimle V, Kufer T. The N-terminal domain of NLRC5 confers transcriptional activity for MHC class I and II gene expression. J Immunol. 2014;193:3090-100 pubmed publisher
    ..Recently, another NLR protein, NLRC5, was shown to drive MHC class I expression...
  81. Zupin L, Navarra C, Robino A, Bevilacqua L, Di Lenarda R, Gasparini P, et al. NLRC5 polymorphism is associated with susceptibility to chronic periodontitis. Immunobiology. 2017;222:704-708 pubmed publisher
    ..One polymorphism, namely rs289723, in NLRC5 gene resulted associated with chronic slight and chronic localized periodontitis susceptibility, specifically A/A ..