NKX2-8

Summary

Gene Symbol: NKX2-8
Description: NK2 homeobox 8
Alias: NKX2.8, NKX2H, Nkx2-9, NK-2 homolog 8, NK-2 homolog H, NK2 transcription factor related, locus 8, homeobox protein NK-2 homolog H, homeobox protein Nkx-2.8
Species: human

Top Publications

  1. pmc Genome-wide association mapping in dogs enables identification of the homeobox gene, NKX2-8, as a genetic component of neural tube defects in humans
    Noa Safra
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California, USA
    PLoS Genet 9:e1003646. 2013
  2. ncbi A dynamic switch in the replication timing of key regulator genes in embryonic stem cells upon neural induction
    Pascale Perry
    Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Cell Cycle 3:1645-50. 2004
  3. pmc Genomewide expression profiling in the zebrafish embryo identifies target genes regulated by Hedgehog signaling during vertebrate development
    Jun Xu
    Institute of Molecular and Cell Biology, Singapore
    Genetics 174:735-52. 2006
  4. pmc Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer
    David S Hsu
    Institute for Genome Sciences and Policy, Department of Medicine, and Institute for Statistics and Decision Sciences, Duke University, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 106:5312-7. 2009
  5. doi The tumor-suppressor gene Nkx2.8 suppresses bladder cancer proliferation through upregulation of FOXO3a and inhibition of the MEK/ERK signaling pathway
    Chunping Yu
    State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou 510060, China
    Carcinogenesis 33:678-86. 2012
  6. pmc Motor axon exit from the mammalian spinal cord is controlled by the homeodomain protein Nkx2.9 via Robo-Slit signaling
    Arlene Bravo-Ambrosio
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Development 139:1435-46. 2012
  7. doi Nkx2-8 downregulation promotes angiogenesis and activates NF-κB in esophageal cancer
    Chuyong Lin
    State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Departments of Biochemistry, Microbiology, and Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat Sen University, Guangzhou, Guangdong, China
    Cancer Res 73:3638-48. 2013
  8. doi Methylation-specific digital karyotyping of HPV16E6E7-expressing human keratinocytes identifies novel methylation events in cervical carcinogenesis
    Renske D M Steenbergen
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    J Pathol 231:53-62. 2013
  9. ncbi Identification of 27 5' CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers
    Atsushi Hagihara
    Carcinogenesis Division, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Oncogene 23:8705-10. 2004
  10. doi Regulatory interactions specifying Kolmer-Agduhr interneurons
    Lixin Yang
    Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany
    Development 137:2713-22. 2010

Research Grants

Scientific Experts

  • Renske Dm Steenbergen
  • James Mack
  • Robert Schwartz
  • Thomas Jessell
  • Joseph Locker
  • Cindy Yee
  • KEVIN ANTHONY PETERSON
  • Kevin Peterson
  • JOSEPH LOCKER LOCKER
  • Paul Krieg
  • Susanne Gollin
  • Jianmin Tian
  • Hans Henning Arnold
  • Chuyong Lin
  • Noa Safra
  • Jun Li
  • Libing Song
  • Arlene Bravo-Ambrosio
  • Chunping Yu
  • Joel W Neal
  • Thomas Harris
  • Luca Mazzarella
  • Lixin Yang
  • Andreas Holz
  • David S Hsu
  • Nicholas Genethliou
  • Zaven Kaprielian
  • David Mu
  • O Pabst
  • Scott Powers
  • Matthias Merkenschlager
  • Amanda G Fisher
  • Heike Kollmus
  • Jude Kendall
  • Burcu Guner
  • Jun Xu
  • Allison K Dillon
  • Pascale Perry
  • Ryuji Hamamoto
  • Atsushi Hagihara
  • Fabio Santagati
  • Oliver Pabst
  • Yasuo Kajiyama
  • Aibin Liu
  • Polly J Ferguson
  • Xi Lin
  • Peter J Dickinson
  • Karen M Vernau
  • Mengfeng Li
  • Nicholas Thomas
  • Jueheng Wu
  • Danika L Bannasch
  • Alexander G Bassuk
  • Zena T Wolf
  • Miriam Aguilar
  • Rochelle L Coulson
  • Peta L Hitchens
  • Hui Gong
  • Kun Chen
  • Wenting Liao
  • Yanheng Wu
  • Zhiling Zhang
  • Yonghong Li
  • Zhuowei Liu
  • Fangjian Zhou
  • Liping Liu
  • F Santagati
  • Yi Zhong
  • GRANT MASTICK
  • Xiaohui Zhao
  • Dionne Lutz
  • Jana Sapkar
  • Jorge Soza-Ried
  • Valerie Kouskoff
  • Helle F Jørgensen
  • Stella Pearson
  • Georges Lacaud
  • Juan Sironi
  • Roman Perez-Soler
  • Anna V Terry
  • Alice T Shaw
  • Qiulu Pan
  • Steven Keller
  • Uwe Strahle
  • Sepand Rastegar
  • Ole Kiehn
  • Jesper Ryge
  • Johan Ericson
  • Jose Dias
  • Vera Niederkofler

Detail Information

Publications28

  1. pmc Genome-wide association mapping in dogs enables identification of the homeobox gene, NKX2-8, as a genetic component of neural tube defects in humans
    Noa Safra
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California, USA
    PLoS Genet 9:e1003646. 2013
    ..036). This is the first documentation of a potential role for NKX2-8 in the etiology of NTDs, made possible by investigating the molecular basis of naturally occurring mutations in dogs...
  2. ncbi A dynamic switch in the replication timing of key regulator genes in embryonic stem cells upon neural induction
    Pascale Perry
    Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Cell Cycle 3:1645-50. 2004
    ..These results show that loss of pluripotency (and lineage choice) is associated with extensive and predictable changes in the replication timing of key regulator genes...
  3. pmc Genomewide expression profiling in the zebrafish embryo identifies target genes regulated by Hedgehog signaling during vertebrate development
    Jun Xu
    Institute of Molecular and Cell Biology, Singapore
    Genetics 174:735-52. 2006
    ..Our data also demonstrate for the first time the functionality of the Gli-binding motif in the control of Hedgehog signaling-induced gene expression in the zebrafish embryo...
  4. pmc Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer
    David S Hsu
    Institute for Genome Sciences and Policy, Department of Medicine, and Institute for Statistics and Decision Sciences, Duke University, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 106:5312-7. 2009
    ..This suggests that the cohort of patients with coactivation of TTF-1 and NKX2-8 pathways appears to be resistant to standard cisplatin therapy, suggesting the need for alternative therapies in this cohort of high-risk patients...
  5. doi The tumor-suppressor gene Nkx2.8 suppresses bladder cancer proliferation through upregulation of FOXO3a and inhibition of the MEK/ERK signaling pathway
    Chunping Yu
    State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou 510060, China
    Carcinogenesis 33:678-86. 2012
    ..These findings suggest that Nkx2.8 plays a potential tumor suppressor role in bladder cancer progression and represents a valuable clinical prognostic marker of this disease...
  6. pmc Motor axon exit from the mammalian spinal cord is controlled by the homeodomain protein Nkx2.9 via Robo-Slit signaling
    Arlene Bravo-Ambrosio
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Development 139:1435-46. 2012
    ..Our studies support the view that Nkx2.9 controls SACMN axon exit from the mammalian spinal cord by regulating Robo-Slit signaling...
  7. doi Nkx2-8 downregulation promotes angiogenesis and activates NF-κB in esophageal cancer
    Chuyong Lin
    State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Departments of Biochemistry, Microbiology, and Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat Sen University, Guangzhou, Guangdong, China
    Cancer Res 73:3638-48. 2013
    ..Taken together, our results showed that Nkx2-8 functions as a tumor suppressor in ESCCs, the downregulation of which contributes to NF-κB activation and ESCC angiogenesis...
  8. doi Methylation-specific digital karyotyping of HPV16E6E7-expressing human keratinocytes identifies novel methylation events in cervical carcinogenesis
    Renske D M Steenbergen
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    J Pathol 231:53-62. 2013
    ..These genes may provide promising triage markers to assess the presence of (pre)cancerous cervical lesions in hrHPV-positive women...
  9. ncbi Identification of 27 5' CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers
    Atsushi Hagihara
    Carcinogenesis Division, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Oncogene 23:8705-10. 2004
    ..MSP of 24 primary pancreatic cancers showed that all these genes, except for THBD, were methylated in at least one cancer. Some of those were suggested to be potentially involved in pancreatic cancer development and progression...
  10. doi Regulatory interactions specifying Kolmer-Agduhr interneurons
    Lixin Yang
    Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany
    Development 137:2713-22. 2010
    ..Instead, olig2 and gata3 are required for the differentiation of gad67-expressing KA' cells. This suggests that the layout of regulatory networks is crucially dependent on the lineage that differs between KA' and KA' cells...
  11. doi Embryonic stem cell-derived hemangioblasts remain epigenetically plastic and require PRC1 to prevent neural gene expression
    Luca Mazzarella
    Lymphocyte Development Group, Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom
    Blood 117:83-7. 2011
    ..These data reinforce the importance of PRC1 for normal hematopoietic differentiation and reveal an unexpected epigenetic plasticity of mesoderm-committed hemangioblasts...
  12. pmc The transcription factors Nkx2.2 and Nkx2.9 play a novel role in floor plate development and commissural axon guidance
    Andreas Holz
    Cell and Molecular Biology, University of Braunschweig, Spielmannstrasse 7, 38106 Braunschweig, Germany
    Development 137:4249-60. 2010
    ..As both factors affect floor plate development, control of commissural axon trajectories might be the underlying mechanism...
  13. pmc Both gene amplification and allelic loss occur at 14q13.3 in lung cancer
    Thomas Harris
    Department of Pathology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York 10461, USA
    Clin Cancer Res 17:690-9. 2011
    ..Because loss of Nkx2-8 increases lung cancer in the mouse, we studied suppressive mechanisms in human lung cancer...
  14. pmc One allele's loss is another's gain: alterations of NKX2-8 in non-small cell lung cancer
    Joel W Neal
    Stanford Cancer Center, Stanford, California, USA
    Clin Cancer Res 17:638-9. 2011
    ..Recent technological advances in genomic profiling have allowed quantitative detection of gene copy numbers, leading to identification of the 14q13.3 gene locus as functionally important in non-small cell lung cancers...
  15. doi Spatially distinct functions of PAX6 and NKX2.2 during gliogenesis in the ventral spinal cord
    Nicholas Genethliou
    The Cyprus Institute of Neurology and Genetics, Airport Avenue, No 6, Agios Dometios 2370, Nicosia, Cyprus
    Biochem Biophys Res Commun 382:69-73. 2009
    ..These data provide important insights into specific functions of PAX6 and NKX2.2 during glial cell specification that have so far remained largely unexplored...
  16. pmc Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer
    Jude Kendall
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 104:16663-8. 2007
    ....
  17. pmc Cloning of zebrafish nkx6.2 and a comprehensive analysis of the conserved transcriptional response to Hedgehog/Gli signaling in the zebrafish neural tube
    Burcu Guner
    Biology Department, University of Massachusetts, Amherst, MA 01003 9297, USA
    Gene Expr Patterns 7:596-605. 2007
    ....
  18. ncbi Nkx2-9 is a novel homeobox transcription factor which demarcates ventral domains in the developing mouse CNS
    O Pabst
    Department of Cell and Molecular Biology, Technical University of Braunschweig, Spielmannstrasse 7, 38106, Braunschweig, Germany
    Mech Dev 73:85-93. 1998
    ..The dynamic expression pattern of Nkx2-9 in ventral domains of the CNS is consistent with a possible role in the specification of a distinct subset of neurons...
  19. ncbi tinman-related genes expressed during heart development in Xenopus
    C S Newman
    Institute for Cellular and Molecular Biology, University of Texas at Austin 78712, USA
    Dev Genet 22:230-8. 1998
    ..Preliminary characterization reveals that Nkx2-9 is expressed in the cardiogenic region of the embryo prior to differentiation, but transcript levels decrease rapidly, in the heart, at about the time that differentiation commences...
  20. ncbi NKX2 gene expression in neuroectoderm but not in mesendodermally derived structures depends on sonic hedgehog in mouse embryos
    O Pabst
    Department of Cell and Molecular Biology, Technical University of Braunschweig, Spielmannstrasse 7, D 38106 Braunschweig, Germany
    Dev Genes Evol 210:47-50. 2000
    ..We found that expression of NKX2.1, NKX2.2, and NKX2.9 in neural domains requires Shh signaling, whereas NKX2.3, NKX2.5 and NKX2.6 expression in endoderm and mesoderm is independent of Shh...
  21. ncbi Comparative analysis of the genomic organization of Pax9 and its conserved physical association with Nkx2-9 in the human, mouse, and pufferfish genomes
    F Santagati
    GSF Research Center for Health and Environment, Institute of Mammalian Genetics, Neuherberg, Germany
    Mamm Genome 12:232-7. 2001
    ..Our results suggest that transcription of Pax9 may be initiated at two alternative start sites and driven by TATA-less promoters...
  22. pmc Regulation of alpha-fetoprotein expression by Nkx2.8
    Yasuo Kajiyama
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Cell Biol 22:6122-30. 2002
    ..8 bound to the active AFP promoter, and antisense inhibition of Nkx2.8 mRNA translation selectively reduced expression of both the endogenous human AFP gene and transfected reporters containing the rat AFP promoter...
  23. ncbi Targeted disruption of the homeobox gene Nkx2.9 reveals a role in development of the spinal accessory nerve
    Oliver Pabst
    Department of Cell and Molecular Biology, Institute of Biochemistry and Biotechnology, Technical University of Braunschweig, 38106 Braunschweig, Germany
    Development 130:1193-202. 2003
    ..Like other Nkx genes expressed in the CNS, Nkx2.9 seems to be involved in converting positional information into cell fate decisions...
  24. pmc Identification of Cis-regulatory elements in the mouse Pax9/Nkx2-9 genomic region: implication for evolutionary conserved synteny
    Fabio Santagati
    GSF National Research Center for Environment and Health, Institute of Developmental Genetics, D 85764 Neuherberg, Germany
    Genetics 165:235-42. 2003
    ..We propose such an intersecting organization of cis-regulatory sequences in multigenic regions as a possible mechanism that maintains evolutionary conserved synteny...
  25. ncbi SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells
    Ryuji Hamamoto
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nat Cell Biol 6:731-40. 2004
    ..Furthermore, activation of SMYD3 may be a key factor in human carcinogenesis...
  26. ncbi Molecular control of spinal accessory motor neuron/axon development in the mouse spinal cord
    Allison K Dillon
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 25:10119-30. 2005
    ..Furthermore, in the absence of the transcription factor Nkx2.9, SACMN axons fail to exit the CNS. Together, these findings suggest molecular mechanisms that are likely to regulate key steps in SACMN development...
  27. ncbi Loss of Nkx2.8 deregulates progenitor cells in the large airways and leads to dysplasia
    Jianmin Tian
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 66:10399-407. 2006
    ..8-/- mice. Increased proliferation and an altered progenitor relationship caused progressive bronchial pathology, which manifested as widespread dysplasia in the large airways of 1-year-old Nkx2.8-/- mice...
  28. ncbi A novel nk-2-related transcription factor associated with human fetal liver and hepatocellular carcinoma
    G A Apergis
    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 273:2917-25. 1998
    ..Moreover, the nk-2-related genes are developmental regulators, and nkx-2.8 is the first such factor associated with liver development...

Research Grants27

  1. The role of Nkx genes in hypothalamic & NAc development
    Cindy Yee; Fiscal Year: 2006
    ..I will analyze Nkx2.1 function in dorsoventral patterning, specification and differentiation of NPY+/GABA+ neurons in the hypothalamus and NAc using cre recombinase-mediated gene inactivation technology in mice. ..
  2. A mouse model of stem cell deregulation and lung cancer
    Joseph Locker; Fiscal Year: 2007
    ..8 expression in human lung cancer cells. Expression profiles from these cells will be com- pared to those obtained from mouse bronchial cell fractions, to determine specific relationships between tumor and stem cell regulation. ..
  3. A mouse model of stem cell deregulation and lung cancer
    JOSEPH LOCKER LOCKER; Fiscal Year: 2010
    ..8 expression in human lung cancer cells. Expression profiles from these cells will be com- pared to those obtained from mouse bronchial cell fractions, to determine specific relationships between tumor and stem cell regulation. ..