Gene Symbol: NKX2-1
Description: NK2 homeobox 1
Alias: BCH, BHC, NK-2, NKX2.1, NKX2A, NMTC1, T/EBP, TEBP, TITF1, TTF-1, TTF1, homeobox protein Nkx-2.1, NK-2 homolog A, homeobox protein NK-2 homolog A, thyroid nuclear factor 1, thyroid transcription factor 1, thyroid-specific enhancer-binding protein
Species: human
Products:     NKX2-1

Top Publications

  1. Klingen T, Chen Y, Gundersen M, Aas H, Westre B, Sauer T. Thyroid transcription factor-1 positive primary breast cancer: a case report with review of the literature. Diagn Pathol. 2010;5:37 pubmed publisher
    ..On PET scan and CT follow up there were no other tumours found in this patient. We are not aware of any previously reported TTF-1 positive primary breast carcinoma with ductal differentiation. ..
  2. Ersahin C, Bandyopadhyay S, Bhargava R. Thyroid transcription factor-1 and "basal marker"--expressing small cell carcinoma of the breast. Int J Surg Pathol. 2009;17:368-72 pubmed publisher
    ..An unequivocal in situ component was identified intimately admixed with the invasive carcinoma. To the authors' knowledge, this is the first report of breast small cell carcinoma showing the expression of "basal markers."..
  3. Berghmans T, Paesmans M, Mascaux C, Martin B, Meert A, Haller A, et al. Thyroid transcription factor 1--a new prognostic factor in lung cancer: a meta-analysis. Ann Oncol. 2006;17:1673-6 pubmed
    The aim of this study was to determine the prognostic role for survival of thyroid transcription factor 1 (TTF-1) in lung cancer...
  4. Kolla V, Gonzales L, Gonzales J, Wang P, Angampalli S, Feinstein S, et al. Thyroid transcription factor in differentiating type II cells: regulation, isoforms, and target genes. Am J Respir Cell Mol Biol. 2007;36:213-25 pubmed
    ..In addition, knockdown of TTF-1 inhibited 72 of 274 other genes induced by hormones. We conclude that 42-kD TTF-1 is required for induction of a subset of regulated genes during type II cell differentiation. ..
  5. Guazzi S, Price M, De Felice M, Damante G, Mattei M, Di Lauro R. Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity. EMBO J. 1990;9:3631-9 pubmed
  6. Mukhopadhyay S, Katzenstein A. Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6. Am J Surg Pathol. 2011;35:15-25 pubmed publisher
    ..Discrepancies in immunohistochemical staining between biopsies and resections are uncommon. ..
  7. Cao Y, Vo T, Millien G, Tagne J, Kotton D, Mason R, et al. Epigenetic mechanisms modulate thyroid transcription factor 1-mediated transcription of the surfactant protein B gene. J Biol Chem. 2010;285:2152-64 pubmed publisher
    ..b>Thyroid transcription factor 1 (Nkx2-1) regulates Sftpb gene expression in various species...
  8. Breedveld G, van Dongen J, Danesino C, Guala A, Percy A, Dure L, et al. Mutations in TITF-1 are associated with benign hereditary chorea. Hum Mol Genet. 2002;11:971-9 pubmed
    Benign hereditary chorea (BHC) (MIM 118700) is an autosomal dominant movement disorder...
  9. Fujita J, Ohtsuki Y, Bandoh S, Ueda Y, Kubo A, Tojo Y, et al. Expression of thyroid transcription factor-1 in 16 human lung cancer cell lines. Lung Cancer. 2003;39:31-6 pubmed
    ..Our present study demonstrates that the frequency of TTF-1 expression in the nucleus was very low in human lung cancer cell lines; however, their cytoplasmic positivities should be further investigated. ..

More Information


  1. Maeda Y, Hunter T, Loudy D, Dave V, Schreiber V, Whitsett J. PARP-2 interacts with TTF-1 and regulates expression of surfactant protein-B. J Biol Chem. 2006;281:9600-6 pubmed
    b>Thyroid transcription factor 1 (TTF-1/Nkx-2.1) plays a critical role in lung morphogenesis and regulates the expression of lung-specific genes, including the surfactant proteins required for pulmonary function after birth...
  2. Ye J, Findeis Hosey J, Yang Q, McMahon L, Yao J, Li F, et al. Combination of napsin A and TTF-1 immunohistochemistry helps in differentiating primary lung adenocarcinoma from metastatic carcinoma in the lung. Appl Immunohistochem Mol Morphol. 2011;19:313-7 pubmed publisher
  3. Kwei K, Kim Y, Girard L, Kao J, Pacyna Gengelbach M, Salari K, et al. Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer. Oncogene. 2008;27:3635-40 pubmed publisher
    ..The smallest region of recurrent amplification spanned the homeobox transcription factor TITF1 (thyroid transcription factor 1; also called NKX2-1), previously linked to normal lung development and function...
  4. Liu D, Yi M, Smith M, Mendelson C. TTF-1 response element is critical for temporal and spatial regulation and necessary for hormonal regulation of human surfactant protein-A2 promoter activity. Am J Physiol Lung Cell Mol Physiol. 2008;295:L264-71 pubmed publisher
  5. Kubba L, McCluggage W, Liu J, Malpica A, Euscher E, Silva E, et al. Thyroid transcription factor-1 expression in ovarian epithelial neoplasms. Mod Pathol. 2008;21:485-90 pubmed publisher
    ..30 mucinous neoplasms of low malignant potential, and 10 clear cell carcinomas were stained with anti-TTF1-antibody...
  6. Garcia Barcelo M, Lau D, Ngan E, Leon T, Liu T, So M, et al. Evaluation of the thyroid transcription factor-1 gene (TITF1) as a Hirschsprung's disease locus. Ann Hum Genet. 2007;71:746-54 pubmed
    ..We previously showed that RET transcription was decreased due to alteration of the TITF1 binding site by two HSCR-associated RET promoter single nucleotide polymorphisms (SNPs)...
  7. Furuya F, Shimura H, Miyazaki A, Taki K, Ohta K, Haraguchi K, et al. Adenovirus-mediated transfer of thyroid transcription factor-1 induces radioiodide organification and retention in thyroid cancer cells. Endocrinology. 2004;145:5397-405 pubmed
    ..These results indicate that AdTTF-1 specifically induces iodide organification and retards iodide efflux in thyroid cancer cells in vitro and in vivo...
  8. Myong N. Thyroid transcription factor-1 (TTF-1) expression in human lung carcinomas: its prognostic implication and relationship with wxpressions of p53 and Ki-67 proteins. J Korean Med Sci. 2003;18:494-500 pubmed
  9. Ikeda K, Clark J, Shaw White J, Stahlman M, Boutell C, Whitsett J. Gene structure and expression of human thyroid transcription factor-1 in respiratory epithelial cells. J Biol Chem. 1995;270:8108-14 pubmed
    ..The conservation and distribution of TTF-1 in the human respiratory tract support its role in the regulation of lung development and surfactant homeostasis. ..
  10. Garcia Barcelo M, Ganster R, Lui V, Leon T, So M, Lau A, et al. TTF-1 and RET promoter SNPs: regulation of RET transcription in Hirschsprung's disease. Hum Mol Genet. 2005;14:191-204 pubmed
    ..We also present a detailed profile of the RET gene in our population, which provides an insight into the higher incidence of the disease in China. ..
  11. Krude H, Schütz B, Biebermann H, von Moers A, Schnabel D, Neitzel H, et al. Choreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsufficiency. J Clin Invest. 2002;109:475-80 pubmed
    ..Moreover, the association of symptoms in the patients with NKX2-1 mutations points to an important role of human NKX2-1 in the development and function of thyroid, basal ganglia, and lung, as already described for rodents. ..
  12. Provenzano C, Veneziano L, Appleton R, Frontali M, Civitareale D. Functional characterization of a novel mutation in TITF-1 in a patient with benign hereditary chorea. J Neurol Sci. 2008;264:56-62 pubmed
    Benign hereditary chorea (BHC) is an autosomal dominant disorder of early onset characterised by non progressive choreic movements with normal cognitive function occasionally associated with hypothyroidism and respiratory problems...
  13. Homminga I, Pieters R, Langerak A, de Rooi J, Stubbs A, Verstegen M, et al. Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia. Cancer Cell. 2011;19:484-97 pubmed publisher
    ..We propose NKX2-1, NKX2-2, and MEF2C as T-ALL oncogenes that are activated by various rearrangements. ..
  14. Gudmundsson J, Sulem P, Gudbjartsson D, Jonasson J, Sigurdsson A, Bergthorsson J, et al. Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations. Nat Genet. 2009;41:460-4 pubmed publisher
    ..3 (OR = 1.37; P = 2.0 x 10(-9)). The gene nearest to the 9q22.33 locus is FOXE1 (TTF2) and NKX2-1 (TTF1) is among the genes located at the 14q13.3 locus...
  15. Lettre G, Jackson A, Gieger C, Schumacher F, Berndt S, Sanna S, et al. Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet. 2008;40:584-91 pubmed publisher
    ..These results expand the picture of the biological regulation of human height and of the genetic architecture of this classical complex trait. ..
  16. Perner S, Wagner P, Soltermann A, Lafargue C, Tischler V, Weir B, et al. TTF1 expression in non-small cell lung carcinoma: association with TTF1 gene amplification and improved survival. J Pathol. 2009;217:65-72 pubmed publisher
    ..3, which contains the TTF1 gene...
  17. Yamaguchi T, Yanagisawa K, Sugiyama R, Hosono Y, Shimada Y, Arima C, et al. NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma. Cancer Cell. 2012;21:348-61 pubmed publisher
    We and others previously identified NKX2-1, also known as TITF1 and TTF-1, as a lineage-survival oncogene in lung adenocarcinomas...
  18. Sun P, Seol H, Lee H, Yoo S, Kim H, Xu X, et al. High incidence of EGFR mutations in Korean men smokers with no intratumoral heterogeneity of lung adenocarcinomas: correlation with histologic subtypes, EGFR/TTF-1 expressions, and clinical features. J Thorac Oncol. 2012;7:323-30 pubmed publisher
    ..In addition, relatively high incidence of EGFR mutations in Korean men who smoked with adenocarcinoma histology suggests that these patients should not be left behind EGFR mutation test. ..
  19. Li C, Zhu N, Tan R, Ballard P, Derynck R, Minoo P. Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors. J Biol Chem. 2002;277:38399-408 pubmed
    ..1 was not affected. We conclude that SMAD3 interactions with the positive regulators NKX2.1 and HNF-3 underlie the molecular basis for TGF-beta-induced repression of Sp-B gene transcription. ..
  20. Watanabe H, FRANCIS J, Woo M, Etemad B, Lin W, Fries D, et al. Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target. Genes Dev. 2013;27:197-210 pubmed publisher
    ..Our findings provide new insight into the transcriptional regulatory network of NKX2-1 and suggest that LMO3 is a transcriptional signal transducer in NKX2-1-amplified lung adenocarcinomas. ..
  21. Siami K, McCluggage W, Ordonez N, Euscher E, Malpica A, Sneige N, et al. Thyroid transcription factor-1 expression in endometrial and endocervical adenocarcinomas. Am J Surg Pathol. 2007;31:1759-63 pubmed
    ..It should also be taken into consideration in the evaluation of adenocarcinomas involving the lung in patients with a history of a gynecologic malignancy. ..
  22. Winslow M, Dayton T, Verhaak R, Kim Kiselak C, Snyder E, Feldser D, et al. Suppression of lung adenocarcinoma progression by Nkx2-1. Nature. 2011;473:101-4 pubmed publisher
    ..Cross-species analysis identified the NK2-related homeobox transcription factor Nkx2-1 (also called Ttf-1 or Titf1) as a candidate suppressor of malignant progression...
  23. Tanaka H, Yanagisawa K, Shinjo K, Taguchi A, Maeno K, Tomida S, et al. Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1. Cancer Res. 2007;67:6007-11 pubmed
  24. Liu X, Li W, Zhao X, Gao C, Zhao W, Jiang J, et al. [Clinical Characteristics and Treatment Efficacy of Children with SIL/TAL1 Positive T-Cell Acute Lymphoblastic Leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016;24:681-6 pubmed publisher
    ..The treatment efficacy in children with SIL-TAL1 positive T-ALL was compared between BCH-2003 and CCLG-2008 protocol. Out of 101 cases, 22 cases (21.9%) of T-ALL carried SIL-TAL1 fusion gene...
  25. Song D, Ko G, Lee J, Lee J, Lee G, Kim H, et al. Myoferlin expression in non-small cell lung cancer: Prognostic role and correlation with VEGFR-2 expression. Oncol Lett. 2016;11:998-1006 pubmed
    ..As VEGFR-2 is a significant target for novel anticancer therapies, it is anticipated that myoferlin may also possess the potential to become a novel clinical target for the treatment of NSCLC. ..
  26. Vicario A, Abellán A, Medina L. Embryonic Origin of the Islet1 and Pax6 Neurons of the Chicken Central Extended Amygdala Using Cell Migration Assays and Relation to Different Neuropeptide-Containing Cells. Brain Behav Evol. 2015;85:139-69 pubmed publisher
  27. Yan C, Naltner A, Conkright J, Ghaffari M. Protein-protein interaction of retinoic acid receptor alpha and thyroid transcription factor-1 in respiratory epithelial cells. J Biol Chem. 2001;276:21686-91 pubmed
    ..Previous studies demonstrated that retinoic acid receptors (RARs) and thyroid transcription factor 1 (TTF-1) stimulated SP-B gene expression in respiratory epithelial cells...
  28. Sohail A, Faraz M, Arif H, Bhat S, Siddiqui A, Bano B. Deciphering the interaction of bovine heart cystatin with ZnO nanoparticles: Spectroscopic and thermodynamic approach. Int J Biol Macromol. 2017;95:1056-1063 pubmed publisher
    ..study zinc oxide nanoparticles (ZnO-NPs) were synthesized and subjected to interact with buffalo heart cystatin (BHC), purified from buffalo heart, to assess the effect(s) of ZnO-NPs on the structure and function of BHC...
  29. Stoll L, Johnson M, Gabrielson E, Askin F, Clark D, Li Q. The utility of napsin-A in the identification of primary and metastatic lung adenocarcinoma among cytologically poorly differentiated carcinomas. Cancer Cytopathol. 2010;118:441-9 pubmed publisher
    ..The current results indicate that the dual use of both markers may be necessary to improve diagnostic accuracy. ..
  30. Vyas M, Harigopal M. Metastatic thyroid carcinoma presenting as malignant pleural effusion: A cytologic review of 5 cases. Diagn Cytopathol. 2016;44:1085-1089 pubmed publisher
    ..Diagn. Cytopathol. 2016;44:1085-1089. © 2016 Wiley Periodicals, Inc. ..
  31. Cao Z, Zhao L, Kuang J, Chen Q, Zhu G, Zhang K, et al. Vehicles as outdoor BFR sources: Evidence from an investigation of BFR occurrence in road dust. Chemosphere. 2017;179:29-36 pubmed publisher
    The distribution of brominated flame retardants (BFRs) including ?8PBDEs, DBDPE, BTBPE, EH-TBB, BEH-TEBP and PBEB in road dust (RD) collected in Xinxiang, China was characterized...
  32. Acosta A, Hamedani F, Meeks J, Wu S. Primary Ureteral Thyroid Transcription Factor 1-Positive Small Cell Neuroendocrine Carcinoma: Case Report and Review of the Literature. Int J Surg Pathol. 2015;23:472-7 pubmed publisher
    ..Besides the usual neuroendocrine immunomarkers, this tumor showed intense positivity for TTF-1 (thyroid transcription factor-1), a phenomenon that has been described for extrapulmonary SmCC of other locations. ..
  33. Wei W, Mao N, Ning S, Li J, Liu H, Xie T, et al. An Analysis of EGFR Mutations among 1506 Cases of Non-Small Cell Lung Cancer Patients in Guangxi, China. PLoS ONE. 2016;11:e0168795 pubmed publisher
    ..Up to now, there are only very limited data on the association of TTF1/EGFR protein positivity and EGFR mutation status in NSCLC...
  34. Fernández Aceñero M, Córdova S, Manzarbeitia F, Medina C. Immunohistochemical profile of urothelial and small cell carcinomas of the bladder. Pathol Oncol Res. 2011;17:519-23 pubmed publisher
    ..of different organs has been shown to express markers of neuroendocrine differentiation, and also thyroid transcription factor 1 (TTF-1)...
  35. Zhao X, Zhou Y, Kong W, Gong B, Chen D, Wei J, et al. Multi-residue analysis of 26 organochlorine pesticides in Alpinia oxyphylla by GC-ECD after solid phase extraction and acid cleanup. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1017-1018:211-220 pubmed publisher
    ..3 samples were found to be positive with four pesticides (α-BHC, quintozene, trans-chlordane and op'-DDD), which were confirmed by gas chromatography-mass spectrometry (GC-MS) in ..
  36. Wei W, Chen X, Zou Y, Chang L, An W, Wan Y, et al. Prediction of outcomes by early treatment responses in childhood T-cell acute lymphoblastic leukemia: a retrospective study in China. BMC Pediatr. 2015;15:80 pubmed publisher
    ..2003 to December 2012, 74 consecutive patients aged ≤ 15 years with newly diagnosed T-ALL were treated with BCH-2003 protocol or CCLG-2008 protocol in the Department of Pediatric, Institute of Hematology and Blood Diseases ..
  37. Shomura S, Suzuki H, Yada M, Kondo C. [Surgical Case of Pulmonary Enteric Adenocarcinoma]. Kyobu Geka. 2017;70:779-781 pubmed
    ..Immunohistochemical staining was positive for TTF-1, CK-7 and CK-20. Postoperative screening of the abdomen revealed no suspicious primary lesion in the colon and the tumor was diagnosed as a pulmonary enteric adenocarcinoma...
  38. Yoshimura K, Inoue Y, Mori K, Iwashita Y, Kahyo T, Kawase A, et al. Distinct prognostic roles and heterogeneity of TTF1 copy number and TTF1 protein expression in non-small cell lung cancer. Genes Chromosomes Cancer. 2017;56:570-581 pubmed publisher
    b>Thyroid transcription factor 1 (TTF1) located on chromosome band 14q13.3 is an oncogene and a suppressor gene in non-small cell lung cancer (NSCLC)...
  39. Amin S, Beattie A, Ling X, Jennings L, Guitart J. Primary Cutaneous Mammary Analog Secretory Carcinoma With ETV6-NTRK3 Translocation. Am J Dermatopathol. 2016;38:842-845 pubmed
    ..performed, including estrogen receptor, progesterone receptor, HER2/neu, paired box 8 (PAX8), and thyroid transcription factor 1 (TTF1)...
  40. Asa S, Mete O. What's new in pituitary pathology?. Histopathology. 2018;72:133-141 pubmed publisher
    ..The remaining challenge is clarification of the pathogenetic mechanisms underlying the development of many of these disorders...
  41. Anastasiades P, Marques Smith A, Lyngholm D, Lickiss T, Raffiq S, Kätzel D, et al. GABAergic interneurons form transient layer-specific circuits in early postnatal neocortex. Nat Commun. 2016;7:10584 pubmed publisher
    ..The innervation patterns of immature cortical interneuron circuits are thus neither static nor progressively strengthened but follow a layer-specific choreography of transient connections that differ from those of the adult brain. ..
  42. Vuong H, Kondo T, Tran T, Oishi N, Nakazawa T, Mochizuki K, et al. Spindle cell oncocytoma of adenohypophysis: Report of a case and immunohistochemical review of literature. Pathol Res Pract. 2016;212:222-5 pubmed publisher
    ..Immunohistochemical examination revealed expression of anti-mitochondria antibody (AMA), vimentin, thyroid transcription factor 1 (TTF-1), epithelial membrane antigen (EMA) and galectin-3...
  43. Iwamoto M, Nakatani Y, Fugo K, Kishimoto T, Kiyokawa T. Napsin A is frequently expressed in clear cell carcinoma of the ovary and endometrium. Hum Pathol. 2015;46:957-62 pubmed publisher
    ..7%) of 15 EM-CCC cases but was rare in O-EC and EM-EC (7.7% and 4.5%) and undetectable in HGSC cases. Thyroid transcription factor 1 was not expressed in O-CCC but was detected in 1 (6.7%) of 15 EM-CCC, 3 (23.1%) of 13 O-EC, 2 (5...
  44. Dupain C, Ali H, Mouhoub T, Urbinati G, Massaad Massade L. Induction of TTF-1 or PAX-8 expression on proliferation and tumorigenicity in thyroid carcinomas. Int J Oncol. 2016;49:1248-58 pubmed publisher
    ..It will also be important to study the two thyroid transcription factors as part of a duo. This could open in the long-term, new therapeutic perspectives for thyroid carcinomas. ..
  45. Pohlenz J, Dumitrescu A, Zundel D, Martine U, Schönberger W, Koo E, et al. Partial deficiency of thyroid transcription factor 1 produces predominantly neurological defects in humans and mice. J Clin Invest. 2002;109:469-73 pubmed
    Three genes, TTF1, TTF2, and PAX8, involved in thyroid gland development and migration have been identified. Yet systematic screening for defects in these genes in thyroid dysgenesis gave essentially negative results...
  46. Duodu G, Goonetilleke A, Ayoko G. Optimization of in-cell accelerated solvent extraction technique for the determination of organochlorine pesticides in river sediments. Talanta. 2016;150:278-85 pubmed publisher
    ..5 g of silica gel, 105 °C, and 4:3 v/v DCM: hexane mixture. With the exception of two compounds (α-BHC and Aldrin) whose recoveries were low (59.73 and 47...
  47. Otsubo K, Goto H, Nishio M, Kawamura K, Yanagi S, Nishie W, et al. MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation. Oncogene. 2017;36:4201-4211 pubmed publisher
    ..Thus, a MOB1-YAP1/TAZ-NKX2.1 axis is essential for normal lung homeostasis and expression of the collagen XVII protein necessary for alveolar stem cell maintenance in the lung niche. ..
  48. Steiner F, Hauser Kronberger C, Rendl G, Rodrigues M, Pirich C. Expression of Tenascin C, EGFR, E-Cadherin, and TTF-1 in Medullary Thyroid Carcinoma and the Correlation with RET Mutation Status. Int J Mol Sci. 2016;17: pubmed publisher
    ..EGFR is low, and tumors expressing EGFR do not exhibit higher proliferation. TTF-1 does not correlate with RET mutation status and has a weak correlation with tenascin C, E-cadherin, and EGFR expression. ..
  49. Sekine A, Kuroki Y, Urata T, Mori N, Fukuwatari T. Inhibition of Large Neutral Amino Acid Transporters Suppresses Kynurenic Acid Production Via Inhibition of Kynurenine Uptake in Rodent Brain. Neurochem Res. 2016;41:2256-66 pubmed publisher
    ..was investigated in vitro and in vivo using an LATs inhibitor, 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH)...
  50. Sandberg M, Flandin P, Silberberg S, Su Feher L, Price J, Hu J, et al. Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons. Neuron. 2016;91:1260-1275 pubmed publisher
    ..Our integrated approach provides a foundation for elucidating transcriptional networks guiding the development of the MGE and its descendants. ..
  51. Warth A, Penzel R, Lindenmaier H, Brandt R, Stenzinger A, Herpel E, et al. EGFR, KRAS, BRAF and ALK gene alterations in lung adenocarcinomas: patient outcome, interplay with morphology and immunophenotype. Eur Respir J. 2014;43:872-83 pubmed publisher
    ..b>TTF1 expression (hazard ratio (HR) for overall survival 0.61, p=0...
  52. Shah A, Wheeler L, Sessions K, Kuule Y, Agaba E, Merry S. Community perceptions of mental illness in rural Uganda: An analysis of existing challenges facing the Bwindi Mental Health Programme. Afr J Prim Health Care Fam Med. 2017;9:e1-e9 pubmed publisher
    To assess community perceptions of mental illness in the Bwindi Community Hospital (BCH) catchment area: to recognise beliefs about the causes and the treatments for mental illness...
  53. Soares da Silva P, Serrao M. Molecular modulation of inward and outward apical transporters of L-dopa in LLC-PK(1) cells. Am J Physiol Renal Physiol. 2000;279:F736-46 pubmed
    ..to N-(methylamino)-isobutyric acid but competitively inhibited by 2-aminobicyclo(2,2, 1)-heptane-2-carboxylic acid (BHC; IC(50) = 251 microM)...
  54. Maeda Y, Tsuchiya T, Hao H, Tompkins D, Xu Y, Mucenski M, et al. Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung. J Clin Invest. 2012;122:4388-400 pubmed publisher
    ..NKX2-1 inhibited both AP-1 activity and tumor colony formation in vitro. These data demonstrate that NKX2-1 functions in a context-dependent manner in lung tumorigenesis and inhibits Kras(G12D)-driven mucinous pulmonary adenocarcinoma. ..
  55. Hsu D, Acharya C, Balakumaran B, Riedel R, Kim M, Stevenson M, et al. Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer. Proc Natl Acad Sci U S A. 2009;106:5312-7 pubmed publisher
    ..This suggests that the cohort of patients with coactivation of TTF-1 and NKX2-8 pathways appears to be resistant to standard cisplatin therapy, suggesting the need for alternative therapies in this cohort of high-risk patients. ..
  56. Yaman B, Nart D, Ekren P, Çok G, Veral A. Expression of p63, TTF-1 and Maspin in Non-Small Cell Lung Carcinoma and Their Effect on the Prognosis and Differential Diagnosis. Turk Patoloji Derg. 2015;31:163-74 pubmed publisher
    ..Maspin has been identified as a prognostic marker in adenocarcinoma. However, more studies are required to elucidate the significance of maspin. ..
  57. Acebron A, Aza Blanc P, Rossi D, Lamas L, Santisteban P. Congenital human thyroglobulin defect due to low expression of the thyroid-specific transcription factor TTF-1. J Clin Invest. 1995;96:781-5 pubmed
    ..Moreover, these data suggest that TTF-1 and Pax-8 would be differentially regulating thyroglobulin and thyroperoxidase gene transcription. ..
  58. Pournourmohammadi S, Grimaldi M, Stridh M, Lavallard V, Waagepetersen H, Wollheim C, et al. Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state?. Int J Biochem Cell Biol. 2017;88:220-225 pubmed publisher
    ..by EGCG upon glucose stimulation and blocked in response to glutamine combined with the allosteric GDH activator BCH (2-aminobicyclo-[2,2,1] heptane-2-carboxylic acid)...
  59. Ferrara A, De Michele G, Salvatore E, Di Maio L, Zampella E, Capuano S, et al. A novel NKX2.1 mutation in a family with hypothyroidism and benign hereditary chorea. Thyroid. 2008;18:1005-9 pubmed publisher
    ..The aim of this study was to establish the genetic defects that cause that phenotype and study the molecular mechanisms of the pathology...
  60. McCluggage W, Kennedy K, Busam K. An immunohistochemical study of cervical neuroendocrine carcinomas: Neoplasms that are commonly TTF1 positive and which may express CK20 and P63. Am J Surg Pathol. 2010;34:525-32 pubmed publisher
    ..Cases were stained with AE1/3, chromogranin, CD56, synaptophysin, PGP9.5, TTF1, p16, p63, CK7, CK20, neurofilament, and CD99...
  61. Srisodsai A, Kurotani R, Chiba Y, Sheikh F, Young H, Donnelly R, et al. Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1. J Biol Chem. 2004;279:54358-68 pubmed
    ..1-dependent pathway. The results further suggest that UGRP1 might be a target for IL-10 anti-inflammatory activities in the lung. ..
  62. Choi D, Kim D, Kanai Y, Wempe M, Endou H, Kim J. JPH203, a selective L-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells. Korean J Physiol Pharmacol. 2017;21:599-607 pubmed publisher
    ..JPH203 and BCH, a non-selective L-type amino acid transporter inhibitor, potently inhibited L-leucine uptake in Saos2 cells...
  63. Maeda Y, Chen G, Xu Y, Haitchi H, Du L, Keiser A, et al. Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation. Am J Respir Crit Care Med. 2011;184:421-9 pubmed publisher
    ..The present data demonstrate a novel function for NKX2-1 in a gene network regulating mucous cell metaplasia and allergic inflammation in the respiratory epithelium. ..
  64. Ragogna P, Graham C, Millet C, Price A, Valijus J, Cowley M, et al. Preparation and characterization of P2BCh ring systems (Ch = S, Se) and their reactivity with N-heterocyclic carbenes. Chemistry. 2017;: pubmed publisher
  65. Rosai J. Immunohistochemical markers of thyroid tumors: significance and diagnostic applications. Tumori. 2003;89:517-9 pubmed
    ..At the practical level, cell type-related markers are much more useful than disease-related markers. Markers said to be of prognostic value in medullary carcinomas are calcitonin, bcl-2, and N-myc...
  66. Zhang H, Fan T, Li W, Li X. Expressions and significances of TTF-1 and PTEN in early endometrial cancer. Eur Rev Med Pharmacol Sci. 2017;21:20-26 pubmed
    ..010. TTF-1 and PTEN can be used as molecular markers for the early diagnosis of endometrial cancer, which are closely related to clinical features and may affect tumor progression by regulating the proliferation activity of tumor cells. ..
  67. Henry G, Malewska A, Mauck R, Gahan J, Hutchinson R, Torrealba J, et al. Molecular pathogenesis of human prostate basal cell hyperplasia. Prostate. 2017;77:1344-1355 pubmed publisher
    ..and luminal epithelia for relief of lower urinary tract symptoms (LUTS) due to BPH, but basal cell hyperplasia (BCH) remains untargeted...
  68. Clarke N, Biscocho J, Kwei K, Davidson J, Sridhar S, Gong X, et al. Integrative Genomics Implicates EGFR as a Downstream Mediator in NKX2-1 Amplified Non-Small Cell Lung Cancer. PLoS ONE. 2015;10:e0142061 pubmed publisher
  69. Cardnell R, Li L, Sen T, Bara R, Tong P, Fujimoto J, et al. Protein expression of TTF1 and cMYC define distinct molecular subgroups of small cell lung cancer with unique vulnerabilities to aurora kinase inhibition, DLL3 targeting, and other targeted therapies. Oncotarget. 2017;8:73419-73432 pubmed publisher
    ..we found two major proteomic subtypes of SCLC characterized by either high thyroid transcription factor-1 (TTF1)/low cMYC protein expression or high cMYC/low TTF1...
  70. Srbecka K, Michalova K, Curcikova R, Michal M, Dubova M, Svajdler M, et al. Spectrum of lesions derived from branchial arches occurring in the thyroid: from solid cell nests to tumors. Virchows Arch. 2017;471:393-400 pubmed publisher
    ..We suggest that the common denominator of these structures is that they all arise due to activation of inflammatory cells around the vestigial structures, which leads to cystic dilatation and proliferation of the epithelial component. ..
  71. Li M, Zheng W, Wei J, Hou C, Yang Y, Sun L, et al. Thyroid transcription factor-1 promotes lymph node metastasis by inducing lymphangiogenesis in ovarian carcinoma. Pathol Res Pract. 2017;213:1054-1058 pubmed publisher
    ..We examined the incidence of thyroid transcription factor 1 expression (clone SPT24) and lymph vessel density (LVD) quantified through D2-40 by ..
  72. Argon A, Nart D, Veral A. The Value of Cytokeratin 5/6, p63 and Thyroid Transcription Factor-1 in Adenocarcinoma, Squamous Cell Carcinoma and Non-Small-Cell Lung Cancer of the Lung. Turk Patoloji Derg. 2015;31:81-8 pubmed publisher
    ..Different staining patterns can be seen with CK5/6 and p63; however, if they are used together with TTF-1 and interpreted correctly, they can be of help for the final diagnosis even in cases in which the morphology is unclear. ..
  73. Kuang J, Abdallah M, Harrad S. Brominated flame retardants in black plastic kitchen utensils: Concentrations and human exposure implications. Sci Total Environ. 2018;610-611:1138-1146 pubmed publisher
    ..EH-TBB), 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE), bis(2-ethylhexyl)-3,4,5,6-tetrabromo-phthalate (BEH-TEBP) and decabromodiphenyl ethane (DBDPE)...
  74. Shalin S, Cifarelli C, Suen J, Gao L. Loss of cytokeratin 20 and acquisition of thyroid transcription factor-1 expression in a merkel cell carcinoma metastasis to the brain. Am J Dermatopathol. 2014;36:904-6 pubmed publisher
    ..Likewise, thyroid transcription factor-1 was initially negative in the tumor but expression was present in metastatic lesions. ..
  75. Stinchcombe T. Current Treatments for Surgically Resectable, Limited-Stage, and Extensive-Stage Small Cell Lung Cancer. Oncologist. 2017;22:1510-1517 pubmed publisher
    ..This review will provide an update on the standard therapies for surgically resected limited-stage small cell lung cancer and extensive-stage small cell lung cancer that have been investigated in recent clinical trials. ..
  76. Rosati A, Berti B, Melani F, Cellini E, Procopio E, Guerrini R. Recurrent drop attacks in early childhood as presenting symptom of benign hereditary chorea caused by TITF1 gene mutations. Dev Med Child Neurol. 2015;57:777-9 pubmed publisher
    ..A heterozygous mutation of the TITF1/NKX2-1 gene (14q13) was detected in both patients, allowing the diagnosis of benign hereditary chorea (BHC)...
  77. Matsubara D, Soda M, Yoshimoto T, Amano Y, Sakuma Y, Yamato A, et al. Inactivating mutations and hypermethylation of the NKX2-1/TTF-1 gene in non-terminal respiratory unit-type lung adenocarcinomas. Cancer Sci. 2017;108:1888-1896 pubmed publisher
    ..Functional assays with the NK2 homeobox 1 (NKX2-1)/thyroid transcription factor 1 (TTF-1) mutants revealed that none of them retain the activity as a transcriptional factor...
  78. Qi J, Rice S, Salzberg A, Runkle E, Liao J, Zander D, et al. MiR-365 regulates lung cancer and developmental gene thyroid transcription factor 1. Cell Cycle. 2012;11:177-86 pubmed publisher
    b>Thyroid transcription factor 1 (TTF-1 or NKX2-1) is an essential fetal lung developmental factor, which can be recurrently activated by gene amplification in adult lung cancer. We have discovered the first microRNA (i.e...
  79. Kondo T, Nakazawa T, Ma D, Niu D, Mochizuki K, Kawasaki T, et al. Epigenetic silencing of TTF-1/NKX2-1 through DNA hypermethylation and histone H3 modulation in thyroid carcinomas. Lab Invest. 2009;89:791-9 pubmed publisher
    ..Our data suggest that epigenetics is involved with inactivation of TTF-1 in thyroid carcinomas, and provide a possible means of using TTF-1 as a target for differentiation-inducing therapy through epigenetic modification. ..
  80. Chen C, Plocik A, Anderson N, Moakley D, Boyi T, Dundes C, et al. Transcriptome and in Vitro Differentiation Profile of Human Embryonic Stem Cell Derived NKX2.1-Positive Neural Progenitors. Stem Cell Rev. 2016;12:744-756 pubmed
    ..These data provide information on the potential origin of interneurons in the human brain. ..