NKX2-1

Summary

Gene Symbol: NKX2-1
Description: NK2 homeobox 1
Alias: BCH, BHC, NK-2, NKX2.1, NKX2A, TEBP, TITF1, TTF-1, TTF1, NK-2 homolog A, homeobox protein NK-2 homolog A, homeobox protein Nkx-2.1, thyroid nuclear factor 1, thyroid transcription factor 1
Species: human

Top Publications

  1. pmc Suppression of lung adenocarcinoma progression by Nkx2-1
    Monte M Winslow
    David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 473:101-4. 2011
  2. doi Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma
    Justin A Bishop
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Hum Pathol 41:20-5. 2010
  3. doi Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6
    Sanjay Mukhopadhyay
    Department of Pathology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    Am J Surg Pathol 35:15-25. 2011
  4. pmc Thyroid transcription factor in differentiating type II cells: regulation, isoforms, and target genes
    Venkatadri Kolla
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA
    Am J Respir Cell Mol Biol 36:213-25. 2007
  5. pmc Foxp2 inhibits Nkx2.1-mediated transcription of SP-C via interactions with the Nkx2.1 homeodomain
    Beiyun Zhou
    Will Rogers Institute Pulmonary Research Center, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Southern California, 2020 Zonal Avenue, Los Angeles, CA 90033, USA
    Am J Respir Cell Mol Biol 38:750-8. 2008
  6. doi NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma
    Tomoya Yamaguchi
    Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Cancer Cell 21:348-61. 2012
  7. pmc Clinical significance of TTF-1 protein expression and TTF-1 gene amplification in lung adenocarcinoma
    Justine A Barletta
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Cell Mol Med 13:1977-86. 2009
  8. doi Thyroid transcription factor-1 inhibits transforming growth factor-beta-mediated epithelial-to-mesenchymal transition in lung adenocarcinoma cells
    Roy Akira Saito
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Cancer Res 69:2783-91. 2009
  9. doi A targeted NKX2.1 human embryonic stem cell reporter line enables identification of human basal forebrain derivatives
    Adam L Goulburn
    Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Victoria, Australia
    Stem Cells 29:462-73. 2011
  10. pmc Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation
    Yutaka Maeda
    Perinatal Institute, Divisions of Neonatology, Perinatal, and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Respir Crit Care Med 184:421-9. 2011

Research Grants

Detail Information

Publications214 found, 100 shown here

  1. pmc Suppression of lung adenocarcinoma progression by Nkx2-1
    Monte M Winslow
    David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 473:101-4. 2011
    ..Cross-species analysis identified the NK2-related homeobox transcription factor Nkx2-1 (also called Ttf-1 or Titf1) as a candidate suppressor of malignant progression...
  2. doi Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma
    Justin A Bishop
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Hum Pathol 41:20-5. 2010
    ..The combined use of napsin A and thyroid transcription factor-1 results in improved sensitivity and specificity for identifying pulmonary adenocarcinoma in primary lung tumors and in a metastatic setting...
  3. doi Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6
    Sanjay Mukhopadhyay
    Department of Pathology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    Am J Surg Pathol 35:15-25. 2011
    ..Discrepancies in immunohistochemical staining between biopsies and resections are uncommon...
  4. pmc Thyroid transcription factor in differentiating type II cells: regulation, isoforms, and target genes
    Venkatadri Kolla
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA
    Am J Respir Cell Mol Biol 36:213-25. 2007
    ..In addition, knockdown of TTF-1 inhibited 72 of 274 other genes induced by hormones. We conclude that 42-kD TTF-1 is required for induction of a subset of regulated genes during type II cell differentiation...
  5. pmc Foxp2 inhibits Nkx2.1-mediated transcription of SP-C via interactions with the Nkx2.1 homeodomain
    Beiyun Zhou
    Will Rogers Institute Pulmonary Research Center, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Southern California, 2020 Zonal Avenue, Los Angeles, CA 90033, USA
    Am J Respir Cell Mol Biol 38:750-8. 2008
    ..1 inhibits Nkx2.1 DNA-binding and transcriptional activity and suggest a mechanism for down-regulation of SP-C (and probably other AT2 cell genes) during transition of AT2 cells to an AT1 cell phenotype...
  6. doi NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma
    Tomoya Yamaguchi
    Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Cancer Cell 21:348-61. 2012
    We and others previously identified NKX2-1, also known as TITF1 and TTF-1, as a lineage-survival oncogene in lung adenocarcinomas...
  7. pmc Clinical significance of TTF-1 protein expression and TTF-1 gene amplification in lung adenocarcinoma
    Justine A Barletta
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Cell Mol Med 13:1977-86. 2009
    ..Patients with no TTF-1 expression or TTF-1 expression and TTF-1 gene amplification tend to have a significantly worse prognosis than patients with TTF-1 expression and no TTF-1 gene amplification...
  8. doi Thyroid transcription factor-1 inhibits transforming growth factor-beta-mediated epithelial-to-mesenchymal transition in lung adenocarcinoma cells
    Roy Akira Saito
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Cancer Res 69:2783-91. 2009
    ....
  9. doi A targeted NKX2.1 human embryonic stem cell reporter line enables identification of human basal forebrain derivatives
    Adam L Goulburn
    Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Victoria, Australia
    Stem Cells 29:462-73. 2011
    ..These studies highlight the diversity of cell types that can be generated from human NKX2.1(+) progenitors and demonstrate the utility of NKX2.1(GFP/w) hESCs for investigating human forebrain development and neuronal differentiation...
  10. pmc Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation
    Yutaka Maeda
    Perinatal Institute, Divisions of Neonatology, Perinatal, and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Respir Crit Care Med 184:421-9. 2011
    ..Elucidation of the molecular mechanisms regulating mucous metaplasia and hypersecretion provides the scientific basis for diagnostic and therapeutic opportunities to improve the care of chronic pulmonary diseases...
  11. doi Combination of napsin A and TTF-1 immunohistochemistry helps in differentiating primary lung adenocarcinoma from metastatic carcinoma in the lung
    Jiqing Ye
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Appl Immunohistochem Mol Morphol 19:313-7. 2011
    ....
  12. ncbi Thyroid transcription factor-1 expression in endometrial and endocervical adenocarcinomas
    Koushan Siami
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Am J Surg Pathol 31:1759-63. 2007
    ..It should also be taken into consideration in the evaluation of adenocarcinomas involving the lung in patients with a history of a gynecologic malignancy...
  13. doi Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia
    Irene Homminga
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Cancer Cell 19:484-97. 2011
    ..We propose NKX2-1, NKX2-2, and MEF2C as T-ALL oncogenes that are activated by various rearrangements...
  14. doi Transcription expression and clinical significance of TTF-1 mRNA in pleural effusion of patients with lung cancer
    Bing Jiang
    Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang 110001, China
    Diagn Cytopathol 36:849-54. 2008
    The aim of this study was to evaluate diagnostic utility of thyroid transcription factor 1 (TTF-1) mRNA in pleural effusions (PEs) of patients with lung cancer, especially primary pulmonary adenocarcinoma (PPA)...
  15. ncbi Role of CBP/p300 and SRC-1 in transcriptional regulation of the pulmonary surfactant protein-A (SP-A) gene by thyroid transcription factor-1 (TTF-1)
    Ming Yi
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9038, USA
    J Biol Chem 277:2997-3005. 2002
    ..cAMP stimulation of SP-A gene expression is mediated by protein kinase A (PKA) phosphorylation of thyroid transcription factor 1 (TTF-1), expressed selectively in developing lung epithelium...
  16. ncbi Thyroid transcription factor 1--a new prognostic factor in lung cancer: a meta-analysis
    T Berghmans
    Department of Intensive Care and Thoracic Oncology, Institut Jules Bordet, Centre des Tumeurs de l Universite Libre de Bruxelles, Belgium
    Ann Oncol 17:1673-6. 2006
    The aim of this study was to determine the prognostic role for survival of thyroid transcription factor 1 (TTF-1) in lung cancer.
  17. ncbi Expression of thyroid transcription factor-1(TTF-1) in fetal and neonatal human lung
    M T Stahlman
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Histochem Cytochem 44:673-8. 1996
    ....
  18. ncbi Expression of thyroid transcription factor-1 in the spectrum of neuroendocrine cell lung proliferations with special interest in carcinoids
    Nathalie Sturm
    Laboratoire de Pathologie Cellulaire, Service de Chirurgie Thoracique and the Lung Cancer Research Group, INSERM 9924, Centre Hospitalo Universitaire Albert Michallon, Grenoble, France
    Hum Pathol 33:175-82. 2002
    ..This challenges the concept of a spectrum of NE proliferations and tumors and lends credence to the alternative hypothesis of a common derivation for SCLC and non-SCLC including LCNEC, with carcinoids deriving from a different stem cell...
  19. pmc Thyroid transcription factor-1 (TTF-1) expression in human lung carcinomas: its prognostic implication and relationship with wxpressions of p53 and Ki-67 proteins
    Na Hye Myong
    Department of Pathology, Dankook University College of Medicine, Cheonan, Korea
    J Korean Med Sci 18:494-500. 2003
    ....
  20. doi Thyroid transcription factor-1 and "basal marker"--expressing small cell carcinoma of the breast
    Cagatay Ersahin
    Department of Pathology, Loyola University Medical Center, Maywood, Illinois, USA
    Int J Surg Pathol 17:368-72. 2009
    ..An unequivocal in situ component was identified intimately admixed with the invasive carcinoma. To the authors' knowledge, this is the first report of breast small cell carcinoma showing the expression of "basal markers."..
  21. doi TTF1 expression in non-small cell lung carcinoma: association with TTF1 gene amplification and improved survival
    S Perner
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical Center, New York, NY, USA
    J Pathol 217:65-72. 2009
    ..3, which contains the TTF1 gene...
  22. pmc Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer
    K A Kwei
    Department of Pathology, Stanford University, Stanford, CA 94305 5176, USA
    Oncogene 27:3635-40. 2008
    ..The smallest region of recurrent amplification spanned the homeobox transcription factor TITF1 (thyroid transcription factor 1; also called NKX2-1), previously linked to normal lung development and function...
  23. ncbi PARP-2 interacts with TTF-1 and regulates expression of surfactant protein-B
    Yutaka Maeda
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 281:9600-6. 2006
    b>Thyroid transcription factor 1 (TTF-1/Nkx-2.1) plays a critical role in lung morphogenesis and regulates the expression of lung-specific genes, including the surfactant proteins required for pulmonary function after birth...
  24. ncbi The synergistic activity of thyroid transcription factor 1 and Pax 8 relies on the promoter/enhancer interplay
    Stefania Miccadei
    Laboratory of Immunology, Regina Elena Cancer Institute, Rome 00158, Italy
    Mol Endocrinol 16:837-46. 2002
    The transcription factors, thyroid transcription factor 1 (TTF-1) and Pax 8, play a pivotal role in the transcriptional regulation of the thyroid differentiation marker genes and in the differentiation of the thyroid follicular cells...
  25. ncbi Nuclear factor of activated T cells regulates transcription of the surfactant protein D gene (Sftpd) via direct interaction with thyroid transcription factor-1 in lung epithelial cells
    Vrushank Dave
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Biol Chem 279:34578-88. 2004
    ..Components of the calcineurin/NFAT pathway were identified in respiratory epithelial cells of the lung that potentially augment rapid assembly of a multiprotein transcription complex on Sftpd promoter inducing SP-D expression...
  26. ncbi Glucocorticoid inhibition of SP-A gene expression in lung type II cells is mediated via the TTF-1-binding element
    Joseph L Alcorn
    Dept of Biochemistry, Univ of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9038, USA
    Am J Physiol Lung Cell Mol Physiol 286:L767-76. 2004
    ..Our finding that Dex increased expression of the NF-kappaB inhibitory partner IkappaB-alpha suggests that the decrease in TBE-binding activity may be caused, in part, by GR inhibition of NF-kappaB interaction with this site...
  27. doi Expression of thyroid transcription factor-1 in colorectal carcinoma
    Bo Xu
    Department of Pathology and Laboratory Medicine, State University of New York at Buffalo, Buffalo, NY, USA
    Appl Immunohistochem Mol Morphol 18:244-9. 2010
    ..Positive nuclear TTF-1 in a metastatic carcinoma does not rule out CRC primary. Clinicopathologic correlation, tumor morphology, and a panel of immunohistochemical markers are essential to render the correct diagnosis...
  28. pmc Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target
    Hideo Watanabe
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA
    Genes Dev 27:197-210. 2013
    ..Our findings provide new insight into the transcriptional regulatory network of NKX2-1 and suggest that LMO3 is a transcriptional signal transducer in NKX2-1-amplified lung adenocarcinomas...
  29. doi Thyroid transcription factor-1 expression in ovarian epithelial neoplasms
    Lena A Kubba
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Mod Pathol 21:485-90. 2008
    ..30 mucinous neoplasms of low malignant potential, and 10 clear cell carcinomas were stained with anti-TTF1-antibody...
  30. doi Opposite roles of FOXA1 and NKX2-1 in lung cancer progression
    Lena Deutsch
    Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Germany
    Genes Chromosomes Cancer 51:618-29. 2012
    ..039). These results suggest that both FOXA1 and NKX2-1 may act as lineage-specific target genes within the 14q amplicon with opposite functions in lung cancer...
  31. doi Psychosis, short stature in benign hereditary chorea: a novel thyroid transcription factor-1 mutation
    Amir Glik
    Department of Neurology and The Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Israel
    Mov Disord 23:1744-7. 2008
    Benign hereditary chorea (BHC) is a rare autosomal dominant nonprogressive movement disorder...
  32. pmc Genome-wide analyses of Nkx2-1 binding to transcriptional target genes uncover novel regulatory patterns conserved in lung development and tumors
    Jean Bosco Tagne
    Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 7:e29907. 2012
    ....
  33. doi Frequent ALK rearrangement and TTF-1/p63 co-expression in lung adenocarcinoma with signet-ring cell component
    Akihiko Yoshida
    Clinical Laboratory Division, National Cancer Center Hospital, Japan
    Lung Cancer 72:309-15. 2011
    ..The characteristic histology, immunoprofile, frequent ALK translocation, and total lack of EGFR or KRAS mutations, may suggest that Ad-SRCC forms a histologically/molecularly coherent subgroup of adenocarcinoma...
  34. doi Thyroid transcription factor-1 amplification and expressions in lung adenocarcinoma tissues and pleural effusions predict patient survival and prognosis
    Xiao Li
    Department of Emergency, Guangdong Provincial Institute of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People s Republic of China
    J Thorac Oncol 7:76-84. 2012
    Thyroid transcription factor-1 (TTF1) plays a role in lung adenocarcinoma development. We investigated the significance of TTF1 in primary lung adenocarcinomas, lymph node metastases, and malignant pleural effusions (MPEs).
  35. ncbi Calreticulin enhances the transcriptional activity of thyroid transcription factor-1 by binding to its homeodomain
    L Perrone
    Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Napoli, Italy
    J Biol Chem 274:4640-5. 1999
    ..We also demonstrate that calreticulin mRNA levels in thyroid cells are under strict control by the thyroid-stimulating hormone, thus implicating calreticulin in the modulation of thyroid gene expression by thyroid-stimulating hormone...
  36. pmc HOXB5 cooperates with NKX2-1 in the transcription of human RET
    Jiang Zhu
    Department of Surgery, Development and Growth, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    PLoS ONE 6:e20815. 2011
    ..Therefore, defects in cis- or trans-regulation of RET by HOXB5 could lead to reduction of RET expression and contribute to the manifestation of the HSCR phenotype...
  37. pmc Induction of sodium iodide symporter gene and molecular characterisation of HNF3 beta/FoxA2, TTF-1 and C/EBP beta in thyroid carcinoma cells
    T Akagi
    Division of Hematology and Oncology, Department of Medicine, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Br J Cancer 99:781-8. 2008
    ..contained binding sites for hepatocyte nuclear factor 3 beta (HNF3 beta)/forkhead box A2 (FoxA2), thyroid transcription factor 1 (TTF-1), and CCAAT/enhancer binding protein (C/EBP beta)...
  38. ncbi Retinoic acid stimulation of the human surfactant protein B promoter is thyroid transcription factor 1 site-dependent
    A Naltner
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 275:56-62. 2000
    ..These findings support a model in which RAR/retinoid X receptor, TTF-1, coactivators, and CBP form a transcription activation complex in the upstream enhancer region of the hSP-B gene...
  39. pmc Thyroid transcription factor-1 (TTF-1) gene: identification of ZBP-89, Sp1, and TTF-1 sites in the promoter and regulation by TNF-α in lung epithelial cells
    Aparajita Das
    Center for Biomedical Research, The University of Texas Health Center at Tyler, 75708 3154, USA
    Am J Physiol Lung Cell Mol Physiol 301:L427-40. 2011
    Thyroid transcription factor-1 (TTF-1/Nkx2.1/TITF1) is a homeodomain-containing transcription factor essential for the morphogenesis and differentiation of the lung...
  40. pmc Epigenetic mechanisms modulate thyroid transcription factor 1-mediated transcription of the surfactant protein B gene
    YuXia Cao
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 285:2152-64. 2010
    ..b>Thyroid transcription factor 1 (Nkx2-1) regulates Sftpb gene expression in various species...
  41. pmc TTF-1 response element is critical for temporal and spatial regulation and necessary for hormonal regulation of human surfactant protein-A2 promoter activity
    Dongyuan Liu
    Department of Biochemistry, North Texas March of Dimes Birth Defects Center, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75235 9038, USA
    Am J Physiol Lung Cell Mol Physiol 295:L264-71. 2008
    ....
  42. pmc Physical and functional interactions between homeodomain NKX2.1 and winged helix/forkhead FOXA1 in lung epithelial cells
    Parviz Minoo
    Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Mol Cell Biol 27:2155-65. 2007
    ..These findings suggest a novel mode of selective gene regulation by proximo-distal gradient distribution of and functional interactions between forkhead and homeodomain transcription factors...
  43. pmc Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer
    David S Hsu
    Institute for Genome Sciences and Policy, Department of Medicine, and Institute for Statistics and Decision Sciences, Duke University, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 106:5312-7. 2009
    ..This suggests that the cohort of patients with coactivation of TTF-1 and NKX2-8 pathways appears to be resistant to standard cisplatin therapy, suggesting the need for alternative therapies in this cohort of high-risk patients...
  44. ncbi The paired domain-containing factor Pax8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription
    Tina Di Palma
    Istituto di Endocrinologia ed Oncologia Sperimentale, CNR and Department Biologia e Patologia Cellulare e Molecolare, Via Pansini 5, 80131 Naples, Italy
    J Biol Chem 278:3395-402. 2003
    ....
  45. ncbi Mutational analysis of thyroid transcription factor-1 gene (TTF-1) in lung carcinomas
    Xiao Yan Bai
    Department of Pathology, School of Basic Medical Science, Southern Medical University, Guangzhou, Guangdong Province, People s Republic of China
    In Vitro Cell Dev Biol Anim 44:17-25. 2008
    ..The analyses of TTF-1 gene missense mutation and synonymous mutation and the loss of TTF-1 protein and mRNA can be regarded as the important indexes of molecular pathology of lung carcinoma...
  46. ncbi Expression of thyroid transcription factor-1 in 16 human lung cancer cell lines
    J Fujita
    First Department of Internal Medicine, Kagawa Medical University, 1750 1, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Lung Cancer 39:31-6. 2003
    ..Our present study demonstrates that the frequency of TTF-1 expression in the nucleus was very low in human lung cancer cell lines; however, their cytoplasmic positivities should be further investigated...
  47. ncbi Erm/thyroid transcription factor 1 interactions modulate surfactant protein C transcription
    Sui Lin
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Biol Chem 281:16716-26. 2006
    ..which is restricted to alveolar type II epithelial cells of the adult lung, is critically dependent on thyroid transcription factor 1 (TTF-1)...
  48. doi Lethal respiratory failure and mild primary hypothyroidism in a term girl with a de novo heterozygous mutation in the TITF1/NKX2.1 gene
    Emilie Maquet
    IRIBHM and Genetics Service, Erasme Hospital, Free University of Brussels ULB, B 1070 Brussels, Belgium
    J Clin Endocrinol Metab 94:197-203. 2009
    b>Thyroid transcription factor 1 (TITF1/NKX2.1) is expressed in the thyroid, lung, ventral forebrain, and pituitary. In the lung, TITF1/NKX2.1 activates the expression of genes critical for lung development and function. Titf/Nkx2...
  49. pmc Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity
    S Guazzi
    European Molecular Biology Laboratory EMBL, Heidelberg, FRG
    EMBO J 9:3631-9. 1990
    ....
  50. doi Epigenetic silencing of TTF-1/NKX2-1 through DNA hypermethylation and histone H3 modulation in thyroid carcinomas
    Tetsuo Kondo
    Department of Pathology, University of Yamanashi, Yamanashi, Japan
    Lab Invest 89:791-9. 2009
    ..Our data suggest that epigenetics is involved with inactivation of TTF-1 in thyroid carcinomas, and provide a possible means of using TTF-1 as a target for differentiation-inducing therapy through epigenetic modification...
  51. doi Five new TTF1/NKX2.1 mutations in brain-lung-thyroid syndrome: rescue by PAX8 synergism in one case
    Aurore Carre
    University Paris Descartes, INSERM U845, 75270 Paris, France
    Hum Mol Genet 18:2266-76. 2009
    b>Thyroid transcription factor 1 (NKX2-1/TITF1) mutations cause brain-lung-thyroid syndrome, characterized by congenital hypothyroidism (CH), infant respiratory distress syndrome (IRDS) and benign hereditary chorea (BHC)...
  52. ncbi Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1
    Achara Srisodsai
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:54358-68. 2004
    ..1-dependent pathway. The results further suggest that UGRP1 might be a target for IL-10 anti-inflammatory activities in the lung...
  53. doi TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation
    Tina Di Palma
    Istituto di Endocrinologia e Oncologia Sperimentale G Salvatore CNR and Dpt Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Via S Pansini 5, 80131 Napoli, Italy
    Exp Cell Res 315:162-75. 2009
    ....
  54. doi Thyroid transcription factor 1 expression in sellar tumors: a histogenetic marker?
    Edward B Lee
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19106, USA
    J Neuropathol Exp Neurol 68:482-8. 2009
    ..Given the role of thyroid transcription factor 1 (TTF-1) in the developing rodent infundibulum and its expression in the adult rat neurohypophysis, we ..
  55. doi NKX2-1 mutations leading to surfactant protein promoter dysregulation cause interstitial lung disease in "Brain-Lung-Thyroid Syndrome"
    Loic Guillot
    INSERM UMR 938, UPMC, Universite Paris 6, France
    Hum Mutat 31:E1146-62. 2010
    ....
  56. pmc Multiple ras downstream pathways mediate functional repression of the homeobox gene product TTF-1
    C Missero
    Stazione Zoologica A Dohrn Villa Comunale, 80121 Naples, Italy
    Mol Cell Biol 20:2783-93. 2000
    ..Our data indicate that the Raf/MEK/ERK cascade may act in concert with an as-yet-uncharacterized signaling pathway activated by V12N38 Ras to repress TTF-1 function and ultimately to inhibit thyroid cell differentiation...
  57. ncbi The DNA glycosylase T:G mismatch-specific thymine DNA glycosylase represses thyroid transcription factor-1-activated transcription
    C Missero
    Stazione Zoologica A Dohrn, Villa Comunale, 80121 Napoli, Italy
    J Biol Chem 276:33569-75. 2001
    ..These findings reveal a previously unsuspected role for the repair enzyme TDG as a transcriptional repressor and open new routes toward the understanding of the regulation of TTF-1 transcriptional activity...
  58. ncbi Structure of the human Nkx2.1 gene
    H Hamdan
    Department of Pediatrics, Women s and Children s Hospital, University of Southern California, School of Medicine, Los Angeles 90033, USA
    Biochim Biophys Acta 1396:336-48. 1998
    ..Analysis of Nkx2.1 genomic DNA fragments suggest that at least two independent regions, one within the first intron and the other 5' of the first exon may mediate the basal promoter activity of the Nkx2.1 gene in lung epithelial cells...
  59. pmc Partial deficiency of thyroid transcription factor 1 produces predominantly neurological defects in humans and mice
    Joachim Pohlenz
    Children s Hospital of Johannes Gutenberg, University of Mainz, Mainz, Germany
    J Clin Invest 109:469-73. 2002
    Three genes, TTF1, TTF2, and PAX8, involved in thyroid gland development and migration have been identified. Yet systematic screening for defects in these genes in thyroid dysgenesis gave essentially negative results...
  60. pmc Choreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsufficiency
    Heiko Krude
    Department of Pediatric Endocrinology, Otto Heubner Center for Pediatrics, Berlin, Germany
    J Clin Invest 109:475-80. 2002
    ..Moreover, the association of symptoms in the patients with NKX2-1 mutations points to an important role of human NKX2-1 in the development and function of thyroid, basal ganglia, and lung, as already described for rodents...
  61. ncbi Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1
    Hisaaki Tanaka
    Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Res 67:6007-11. 2007
    ....
  62. ncbi Evaluation of the thyroid transcription factor-1 gene (TITF1) as a Hirschsprung's disease locus
    Maria Mercè Garcia-Barceló
    Division of Paediatric Surgery, Department of Surgery, Li Ka Shing Faculty of Medicine of the University of Hong Kong, Hong Kong SAR, China
    Ann Hum Genet 71:746-54. 2007
    ..We previously showed that RET transcription was decreased due to alteration of the TITF1 binding site by two HSCR-associated RET promoter single nucleotide polymorphisms (SNPs)...
  63. ncbi TTF-1 and RET promoter SNPs: regulation of RET transcription in Hirschsprung's disease
    Merce Garcia-Barcelo
    Department of Surgery, The University of Hong Kong, Hong Kong SAR, China
    Hum Mol Genet 14:191-204. 2005
    ..We also present a detailed profile of the RET gene in our population, which provides an insight into the higher incidence of the disease in China...
  64. ncbi Glyceraldehyde 3-phosphate-induced DNA or protein modifications severely inhibit the protein/DNA interaction
    M Moro
    Dipartimento di Scienze e Tecnologie Biomediche, , Italy
    Horm Metab Res 29:347-50. 1997
    ..e. in diabetes) or after a long time exposure (i.e. in Gzero-arrested cells during aging)...
  65. ncbi Monitoring of pesticide residues and their metabolites in surface and underground waters of Imathia (N. Greece) by means of solid-phase extraction disks and gas chromatography
    T A Albanis
    Department of Chemistry, University of Ioannina, Greece
    J Chromatogr A 823:59-71. 1998
    ..compounds including propazine, trifluralin, malathion, parathion ethyl, lindane, alpha-benzene hexachloride (alpha-BHC), beta-BHC, 4,4'-DDE and heptachlor were determined in river waters...
  66. ncbi Thyroid transcription factor-1, thyroglobulin, cytokeratin 7, and cytokeratin 20 in thyroid neoplasms
    P A Bejarano
    Department of Pathology, University of Miami School of Medicine, Florida 33136, USA
    Appl Immunohistochem Mol Morphol 8:189-94. 2000
    ..Thyroid tumors are CK7+/CK20-. The panel of antibodies for TG, TTF-1, CK7, and CK20 is useful when the thyroid origin of a metastatic tumor is a consideration...
  67. ncbi Use of thyroid transcription factor 1, PE-10, and cytokeratins 7 and 20 in discriminating between primary lung carcinomas and metastatic lesions in fine-needle aspiration biopsy specimens
    D C Chhieng
    Department of Pathology, University of Alabama at Birmingham, 35249 6823, USA
    Cancer 93:330-6. 2001
    ..It has been shown that antibodies to thyroid transcription factor 1 (TTF-1) and PE-10 are fairly specific markers for primary lung tumors in histologic specimens...
  68. ncbi [Determination of organochlorine pesticide residues in nine herbs by solid-phase extraction and capillary gas chromatography]
    Zheng Yan
    College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China
    Se Pu 23:308-11. 2005
    ..was introduced for determining 13 organochlorine pesticide residues including alpha-benzene hexachloride (BHC), betaBHC, gamma-BHC, delta-BHC, p,p'-dichloro-diphenyl-dichloroethylene (pp'-DDE), p,p'-dichloro-di-phenyl-..
  69. doi Thyroid transcription factor 1 expression in ovarian carcinomas is an independent prognostic factor
    Sawako Fujiwara
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Shouwa ku, Nagoya 466 8550, Japan
    Hum Pathol 41:560-5. 2010
    Tthyroid transcription factor 1 is a marker of lung and thyroid carcinomas, but thyroid transcription factor 1 immunoreactivity is seen in other malignancies...
  70. ncbi Residues of endosulfan and other selected organochlorine pesticides in farm areas of the Lower Fraser Valley, British Columbia, Canada
    Michael T Wan
    Environmental Protection Branch, Environment Canada, Pacific and Yukon Region, 201 401 Burrard Street, Vancouver, BC, Canada
    J Environ Qual 34:1186-93. 2005
    ..endrin aldehyde, heptachlor, and heptachlor epoxide), hexachlorocyclohexanes [alpha-benzene-hexachloride (alpha-BHC), beta-BHC, delta-BHC, and gamma-BHC (lindane)], and DDT-related compounds (p,p-DDT, p,p-DDD, p,p-DDE, and ..
  71. pmc Thyroglobulin repression of thyroid transcription factor 1 (TTF-1) gene expression is mediated by decreased DNA binding of nuclear factor I proteins which control constitutive TTF-1 expression
    M Nakazato
    Cell Regulation Section, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 20:8499-512. 2000
    ..the molecular mechanism by which TG suppresses the prototypic thyroid-restricted transcription factor, thyroid transcription factor 1 (TTF-1), in rat FRTL-5 thyrocytes...
  72. ncbi Sterol response element binding protein and thyroid transcription factor-1 (Nkx2.1) regulate Abca3 gene expression
    Valérie Besnard
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1395-405. 2007
    ..Abca3 gene expression is mediated by discrete cis-acting cassettes that mediate pulmonary cell- and lipid-sensitive pathways regulating surfactant homeostasis...
  73. ncbi Determination of low-level agricultural residues in soft drinks and sports drinks by gas chromatography with mass-selective detection: single-laboratory validation
    Nathan Paske
    Covance Laboratories, 3301 Kinsman Blvd, Madison, WI 53704, USA
    J AOAC Int 90:534-43. 2007
    ..with mass selective detection The pesticide residues determined in this validation were alpha-benzenehexachloride (BHC); beta-BHC; gamma-BHC; delta-BHC; methyl parathion; malathion; chlorpyrifos; aldrin; 2,4-..
  74. ncbi Career development among residents completing primary care and traditional residencies in medicine at the Boston City Hospital, 1974-1983
    R A Witzburg
    Department of Medicine, Boston City Hospital, Boston University School of Medicine, Massachusetts 02118
    J Gen Intern Med 3:48-53. 1988
    A primary care (PC) pathway was initiated within the medical residency program at Boston City Hospital (BCH) in 1974...
  75. ncbi Immunohistochemical study of thyroid transcription factor-1 and HER2/neu in non-small cell lung cancer: strong thyroid transcription factor-1 expression predicts better survival
    Abida K Haque
    Department of Pathology, University of Texas Medical Branch, Galveston 77555 0588, USA
    Appl Immunohistochem Mol Morphol 10:103-9. 2002
    ..The results of this study suggest that strong expression of TTF-1 is an independent predictor of better survival and may be a useful prognostic tool for evaluation of patients with NSCLC...
  76. doi Thyroid transcription factor-1 (TTF-1/Nkx2.1/TITF1) gene regulation in the lung
    Vijay Boggaram
    Department of Molecular Biology, The University of Texas Health Science Center at Tyler, 11937 US Highway 271, Tyler, TX 75708 3154, USA
    Clin Sci (Lond) 116:27-35. 2009
    TTF-1 [thyroid transcription factor-1; also known as Nkx2.1, T/EBP (thyroid-specific-enhancer-binding protein) or TITF1] is a homeodomain-containing transcription factor essential for the morphogenesis and differentiation of the thyroid, ..
  77. doi The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors
    Nicolas Jonckheere
    INSERM, U837, Jean Pierre Aubert Research Center, Lille, France
    FEBS J 278:282-94. 2011
    ..The characterization of the structural and functional features of the Muc5b mucin gene will provide us with a strong base to develop studies in murine models aimed at the identification of its biological role in lung pathophysiology...
  78. ncbi Functional inactivation of the transcription factor Pax8 through oligomerization chain reaction
    Barbara D'Andrea
    Istituto di Endocrinologia ed Oncologia Sperimentale Consiglio Nazionale delie Ricerche and Dipartimento di Biologia e Patologia Cellulare e Molecolare, Italy
    Mol Endocrinol 20:1810-24. 2006
    ..in thyroid cells Pax8 interacts biochemically and functionally with the transcription factor TTF-1 (thyroid transcription factor 1), and that such interaction leads to the synergistic activation of thyroglobulin (Tg) gene expression...
  79. ncbi Thyroid transcription factor 1 immunohistochemistry as an intraoperative diagnostic tool at frozen section for distinction between primary and secondary lung tumors
    David N Butcher
    Department of Histopathology, Royal Brompton Hospital, London SW3 6NP, United Kingdom
    Arch Pathol Lab Med 131:582-7. 2007
    ..Intraoperative distinction between primary and metastatic carcinomas in the lung at frozen section remains problematic...
  80. ncbi Utility of tissue-specific transcription factors thyroid transcription factor 1 and Cdx2 in determining the primary site of metastatic adenocarcinomas to the brain
    Leah B Strickland-Marmol
    University of South Florida Department of Pathology, 12901 Bruce B Downs Blvd, MDC Box 11, Tampa, FL 33612, USA
    Arch Pathol Lab Med 131:1686-90. 2007
    ..Recently, attention has turned to tissue-specific transcription factors, such as thyroid transcription factor 1 (TTF-1) and Cdx2, in the appraisal of metastatic adenocarcinomas.
  81. pmc The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins
    S Guazzi
    Department of Biology and Biotechnology, Istituto Scientifico H S Raffaele, Milano, Italy
    EMBO J 13:3339-47. 1994
    ..Some of the DNA-protein complexes formed by the embryonic extracts are indistinguishable from those generated by HOXB3.(ABSTRACT TRUNCATED AT 250 WORDS)..
  82. ncbi Residues of 18 organochlorine pesticides in 30 traditional Chinese medicines
    Jian Xue
    Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100094, China
    Chemosphere 71:1051-5. 2008
    ..We tested for 18 pesticides: benzene hexachloride (BHC, including alpha-BHC, beta-BHC, gamma-BHC, delta-BHC), heptachlor, heptachlor epoxide, tecnazene, ..
  83. ncbi [Quantitative analysis of thyroid transcription factor-1 mRNA expressions in primary lung cancer and its metastatic foci]
    Xiao Yan Bai
    Department of Pathology, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 28:20-5. 2008
    ....
  84. ncbi Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in models of phasic or incisional pain in rats
    Wiliam A Prado
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, 14049 900, Ribeirao Preto, SP, Brazil
    Brain Res 1018:272-82. 2004
    ..used intrathecal administration of drugs to rats to show that muscarinic or nicotinic agonists such as bethanechol (BCh) and dimethylphenylpiperazinium (DM), respectively, dose-dependently increased the tail flick latency and reduced ..
  85. ncbi [A comparative evaluation of immunohistochemical markers for the differential diagnosis between malignant mesothelioma, non-small cell carcinoma involving the pleura, and benign reactive mesothelial cell proliferation]
    Ewa Szczepulska-Wójcik
    Zakład Patomorfologii Instytutu Gruźlicy i Chorób Płuc w Warszawie
    Pneumonol Alergol Pol 75:57-69. 2007
    ..The objective of this study was to evaluate the significance of selected immunohistochemical stains in differentiating MM from non-small cell lung cancers infiltrating the pleura and from benign reactive mesothelial cell proliferation...
  86. ncbi Immunostaining for thyroid transcription factor-1 on fine-needle aspiration specimens of lung tumors: a comparison of direct smears and cell block preparations
    Jing Liu
    Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at Houston Medical School, Houston, Texas 77030, USA
    Cancer 102:109-14. 2004
    ....
  87. ncbi Effects of of habitats and pesticides on aerobic capacity and survival of soil fauna
    G Tripathi
    Department of Zoology, J N Vyas University, Jodhpur 342 001, India
    Biomed Environ Sci 18:169-75. 2005
    ..Faunal health is largely dependent on their soil environment and available litter quality. So the effects of different soil habitats and pesticides on citrate synthase (CS) activity of soil fauna and its population were studied...
  88. ncbi In vitro characterization of the thyroidal uptake of O-(2-[(18)F]fluoroethyl)-L-tyrosine
    Olaf Prante
    Laboratory of Molecular Imaging, Clinic of Nuclear Medicine, Friedrich Alexander University, D 91054 Erlangen, Germany
    Nucl Med Biol 34:305-14. 2007
    ..We therefore studied several factors potentially governing the uptake of FET in the rat thyroid cell line FRTL-5 in comparison with thyroid tumor cell lines of human origin...
  89. ncbi Determination of polychlorinated biphenyls and chlorinated pesticides in human body fluids and tissues
    K A Bucholski
    , Department of Analytical Chemistry, , Germany
    J Chromatogr A 754:479-85. 1996
    ..The method allows the simultaneous determination of chlorinated pesticides such as aldrin, DDT, DDE, BHC and HCB and is also applicable to other biological matrices, such as bone marrow or tissues.
  90. ncbi Inhibition by a nonmetabolized analogue of L-leucine of protein biosynthesis in tumoral pancreatic islet cells
    M Barreto
    , Centro Asociado al Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Horm Metab Res 21:533-6. 1989
    ..metabolite 2-ketoisocaproate and its nonmetabolized analogue b(+/-)2-aminobicyclo[2,2,1]-heptane-2-carboxylic acid (BCH) upon protein labelling was examined in tumoral islet cells (RINm5F line) exposed to L-[4-3H]phenylalanine or L-[3-..
  91. pmc Endocrine disrupting chemicals in Hungarian canned foods
    Masaharu Yamamoto
    Div of Social and Environmental Medicine Dept of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, 951 8510, Niigata City, Japan
    Environ Health Prev Med 6:273-5. 2002
    The aim of this study was to clarify the worldwide residual levels of organochloride compounds, such as BHC and DDT, which were reportedly concentrated in animal tissues by biological food chains...
  92. ncbi Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms
    Daisuke Nonaka
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Mod Pathol 21:192-200. 2008
    ..In differentiated thyroid neoplasms, no significant difference in expression was seen in all the three transcription factors...
  93. ncbi PCBs and organochlorine pesticide residues in eggs of Audouin's gull (Larus audouinii) in the north-eastern Mediterranean
    V Goutner
    Department of Zoology, School of Biology, Aristotelian University of Thessaloniki, GR 54006, Thessaloniki, Macedonia, Greece
    Mar Pollut Bull 42:377-88. 2001
    Levels of eight PCB congeners (IUPAC 8, 20, 28, 52, 101, 118, 138, 180) and 13 organochlorine pesticides (alpha-BHC, beta-BHC, lindane (gamma-BHC), heptachlor, heptachlor epoxide, aldrin, dieldrin, endrin, 2,4'-DDT, 2,4'-DDD, 4,4'-DDT, 4,..
  94. ncbi [Thyroid transcription factor-1 in pulmonary cytology]
    Silvana Smojver-Jezek
    Klinika za plućne bolesti Jordanovac, Zagreb, Hrvatska
    Acta Med Croatica 62:373-8. 2008
    ..Mucinous bronchioloalveolar carcinomas are usually negative. Immunocytochemistry with a panel of cytokeratins (CK) 7 and 20, along with TTF-1, is recommended for identification of the origin of adenocarcinoma in pulmonary cytology...
  95. doi GCDFP-15 positive and TTF-1 negative primary lung neoplasms: a tissue microarray study of 381 primary lung tumors
    Li J Wang
    Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, USA
    Appl Immunohistochem Mol Morphol 17:505-11. 2009
    ..On whole sections, about half (55%) of GCDFP-15 positive cases were negative and one-third (33%) revealed focal TTF1 staining in areas distinct from the tumor regions that expressed GCDFP-15...
  96. doi TTF1 expression in normal lung neuroendocrine cells and related tumors: immunohistochemical study comparing two different monoclonal antibodies
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, 21100 Varese, Italy
    Virchows Arch 457:497-507. 2010
    Thyroid transcription factor-1 (TTF1) regulates lung morphogenesis and differentiation, and its immunohistochemical expression is used for identifying lung neoplasms...
  97. ncbi Glutaminolysis and insulin secretion: from bedside to bench and back
    Andrea Kelly
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes 51:S421-6. 2002
    ..bicarbonate buffer with 2 mmol/l glutamine using 10 mmol/l 2-aminobicyclo[2,2,1]-heptane-2-carboxylic acid (BCH) or a BCH ramp after 50 or 120 min of glucose deprivation...
  98. ncbi Mutations in TITF1 are not relevant to sporadic and familial chorea of unknown cause
    Peter Bauer
    Medical Genetics, University of Tubingen, Tubingen, Germany
    Mov Disord 21:1734-7. 2006
    ..Benign hereditary chorea (BHC; OMIM 118700) is an autosomal dominant movement disorder. Mutations in the thyroid transcription factor 1 (TITF1) gene have been linked with BHC...
  99. pmc Thyroid transcription factor-1 regulates feeding behavior via melanocortin pathway in the hypothalamus
    Jae Geun Kim
    Department of Biological Sciences, College of Natural Sciences, University of Ulsan, Ulsan, South Korea
    Diabetes 60:710-9. 2011
    ..This study aims to identify the function of TTF-1 in the transcriptional regulation of AgRP and α-MSH synthesis for the control of feeding behavior...
  100. ncbi TTF-1, a homeodomain-containing transcription factor, participates in the control of body fluid homeostasis by regulating angiotensinogen gene transcription in the rat subfornical organ
    Young June Son
    Department of Biological Sciences, College of Natural Sciences, University of Ulsan, Ulsan 680 749, South Korea
    J Biol Chem 278:27043-52. 2003
    ..These results demonstrate a novel role for TTF-1 in the regulation of body fluid homeostasis, exerted via the transactivational control of angiotensinogen synthesis in the subfornical organ...
  101. ncbi [Value of thyroid transcription factor-1 in identification of the prognosis of bronchioloalveolar carcinoma]
    Chang Li Wang
    Department of Lung Tumor, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
    Zhonghua Yi Xue Za Zhi 87:2350-4. 2007
    ....

Research Grants66

  1. NKX2-1, A Candidate Lineage Survival Oncogene in Lung Adenocarcinoma
    Matthew L Meyerson; Fiscal Year: 2010
    ..Our hope is that this understanding will lead to improved diagnosis and treatment of lung adenocarcinoma. ..
  2. Genetic Control of Basal Telencephalic Development
    John L R Rubenstein; Fiscal Year: 2010
    ..Disruption of these mechanisms can cause psychiatric and neurological disorders that include mental retardation, autism, schizophrenia, movement disorders and addiction. ..
  3. Genetic Control of Basal Telencephalic Development
    John Rubenstein; Fiscal Year: 2009
    ..Disruption of these mechanisms can cause psychiatric and neurological disorders that include mental retardation, autism, schizophrenia, movement disorders and addiction. ..
  4. MECHANISMS IN THE REGULATION OF SP-A GENE EXPRESSION
    Carole R Mendelson; Fiscal Year: 2010
    ....
  5. MECHANISMS IN THE REGULATION OF SP-A GENE EXPRESSION
    CAROLE MENDELSON; Fiscal Year: 2009
    ....
  6. MECHANISMS IN THE REGULATION OF SP-A GENE EXPRESSION
    Carole R Mendelson; Fiscal Year: 2011
    ....
  7. NEUROENDOCRINOLOGY OF PUBERTY AND SEXUAL DEVELOPMENT
    Sergio Ojeda; Fiscal Year: 2004
    ..abstract_text> ..
  8. The role of Nkx genes in hypothalamic & NAc development
    Cindy Yee; Fiscal Year: 2006
    ..I will analyze Nkx2.1 function in dorsoventral patterning, specification and differentiation of NPY+/GABA+ neurons in the hypothalamus and NAc using cre recombinase-mediated gene inactivation technology in mice. ..
  9. SYNTHESIS & BIOLOGICAL EVALUATION OF ANTI-HIV NUCLEOSIDE
    David Chu; Fiscal Year: 1993
    ..Additionally, new classes of anti-HIV nucleosides, BCH-189 and dioxolane-T analogues and their C- nucleosides will be synthesized and evaluated as potential anti-HIV ..
  10. THE ROLE OF GATA6 IN LUNG DEVELOPMENT
    Edward E Morrisey; Fiscal Year: 2010
    ..Thus, the studies described in our proposal will greatly enhance our knowledge of the pathways that regulate early lung progenitor development as well as airway regeneration in the adult. ..
  11. REGIONAL PATTERNING IN THE VENTRAL TELENCEPHALON
    GORDON J FISHELL; Fiscal Year: 2010
    ..If we can understand how this population is generated, we will take the first step towards assessing whether we can use gene or cell therapies to ameliorate the devasting consequences associated with cortical interneuron dysfunction. ..
  12. Specification of GABergic Interneurons in the developing Cerebral Cortex
    Stewart Anderson; Fiscal Year: 2009
    ..2 to rescue interneuron fate in Nkx2.1-/- slices. Future experiments will test the functions of other genes with enriched expressed in the dorsal or ventral MGE that have been identified through an array based screen. ..
  13. Specification of GABergic Interneurons in the developing Cerebral Cortex
    Stewart Anderson; Fiscal Year: 2007
    ..2 to rescue interneuron fate in Nkx2.1-/- slices. Future experiments will test the functions of other genes with enriched expressed in the dorsal or ventral MGE that have been identified through an array based screen. ..
  14. Specification of GABergic Interneurons in the developing Cerebral Cortex
    Stewart A Anderson; Fiscal Year: 2010
    ..2 to rescue interneuron fate in Nkx2.1-/- slices. Future experiments will test the functions of other genes with enriched expressed in the dorsal or ventral MGE that have been identified through an array based screen. ..
  15. REGULATORY MECHANISMS IN SURFACTANT SYNTHESIS
    CAROLE MENDELSON; Fiscal Year: 2002
    ..abstract_text> ..
  16. NEUROENDOCRINOLOGY OF PUBERTY AND SEXUAL DEVELOPMENT
    Sergio R Ojeda; Fiscal Year: 2010
    ..4) To examine the hypothesis that a novel gene, termed EAP-1 (Enhanced At. Puberty-1) belongs - along with TTF-1 - to the hierarchy of controlling genes involved in the transcriptional regulation of the pubertal process. ..
  17. Specification of Cortical Interneurons
    Stewart Anderson; Fiscal Year: 2007
    ..In addition Shh function will be studied using conditional knockouts that target Shh expression within the ventral forebrain. ..
  18. NUCLEOSIDE ANALOGS AS ANTICANCER COMPOUNDS
    Yung Chi Cheng; Fiscal Year: 2005
    ..on the study of the anticancer action of a novel L-deoxynucleoside analog, L(-)dioxolane cytidine (L(-)OddC or BCH 4664) discovered in this laboratory and currently undergoing Phase II clinical studies...
  19. Specification of Interneurons of the Cerebral Cortex
    Stewart Anderson; Fiscal Year: 2003
    ..The two main factors under investigation, by manipulations in slice cultures followed by transplantation, are the secreted signalling molecule Sonic Hedghog, and the transcription factor Lhx6. ..