Gene Symbol: NHE3
Description: solute carrier family 9 member A3
Alias: DIAR8, NHE-3, NHE3, sodium/hydrogen exchanger 3, Na(+)/H(+) exchanger 3, solute carrier family 9 (sodium/hydrogen exchanger), solute carrier family 9 (sodium/hydrogen exchanger), member 3, solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
Species: human
Products:     NHE3

Top Publications

  1. Su H, Yeh H, Wang S, Shen M, Chen T, Kiela P, et al. Cell confluence-induced activation of signal transducer and activator of transcription-3 (Stat3) triggers epithelial dome formation via augmentation of sodium hydrogen exchanger-3 (NHE3) expression. J Biol Chem. 2007;282:9883-94 pubmed
    ..Two trans-epithelial transporters, NHE3 and ENaC alpha-subunit, were found to be increased during cell confluence...
  2. Musch M, Arvans D, Walsh Reitz M, Uchiyama K, Fukuda M, Chang E. Synaptotagmin I binds intestinal epithelial NHE3 and mediates cAMP- and Ca2+-induced endocytosis by recruitment of AP2 and clathrin. Am J Physiol Gastrointest Liver Physiol. 2007;292:G1549-58 pubmed
    Apical membrane sodium hydrogen exchanger 3 (NHE3), a major pathway for non-nutrient-dependent intestinal Na(+) absorption, is tightly regulated by second messenger systems that affect its functional activity and membrane trafficking...
  3. Zachos N, Li X, Kovbasnjuk O, Hogema B, Sarker R, Lee L, et al. NHERF3 (PDZK1) contributes to basal and calcium inhibition of NHE3 activity in Caco-2BBe cells. J Biol Chem. 2009;284:23708-18 pubmed publisher
    Elevated intracellular Ca(2+) ([Ca(2+)](i)) inhibition of NHE3 is reconstituted by NHERF2, but not NHERF1, by a mechanism involving the formation of multiprotein signaling complexes...
  4. Dorfman R, Taylor C, Lin F, Sun L, Sandford A, Pare P, et al. Modulatory effect of the SLC9A3 gene on susceptibility to infections and pulmonary function in children with cystic fibrosis. Pediatr Pulmonol. 2011;46:385-92 pubmed publisher
  5. Zachos N, van Rossum D, Li X, Caraveo G, Sarker R, Cha B, et al. Phospholipase C-gamma binds directly to the Na+/H+ exchanger 3 and is required for calcium regulation of exchange activity. J Biol Chem. 2009;284:19437-44 pubmed publisher
    ..studies suggest that phospholipase C-gamma (PLC-gamma) contributes to regulation of sodium/hydrogen exchanger 3 (NHE3) in the small intestine, although the mechanism(s) for this regulation remain unknown...
  6. Oh A, Sohn S, Lee J, Park J, Nam K, Hahm K, et al. ChREBP deficiency leads to diarrhea-predominant irritable bowel syndrome. Metabolism. 2018;85:286-297 pubmed publisher
    ..Moreover the Na+/H+ exchanger NHE3, which is involved in Na+ and water absorption in the intestine, was significantly decreased in HFrD-fed ..
  7. Lang F, Stournaras C. Serum and glucocorticoid inducible kinase, metabolic syndrome, inflammation, and tumor growth. Hormones (Athens). 2013;12:160-71 pubmed
    ..SGK1 up-regulates the Na⁺/K⁺-ATPase, a variety of carriers (e.g. NCC, NKCC, NHE1, NHE3, SGLT1, several amino acid transporters) and many ion channels (e.g...
  8. Li L, Byrd M, Doh K, Dixon P, Lee H, Tiwari S, et al. Absence of renal enlargement in fructose-fed proximal-tubule-select insulin receptor (IR), insulin-like-growth factor receptor (IGF1R) double knockout mice. Physiol Rep. 2016;4: pubmed
    ..of male WT mice led to significantly higher sodium bicarbonate exchanger (NBCe1), sodium hydrogen exchanger (NHE3), sodium phosphate co-transporter (NaPi-2), and transforming growth factor-β (TGF-β) abundances, as compared to ..
  9. Armando I, Asico L, Wang X, Jones J, Serrão M, Cuevas S, et al. Antihypertensive effect of etamicastat in dopamine D2 receptor-deficient mice. Hypertens Res. 2018;41:489-498 pubmed publisher
    ..increased renal protein expressions of ETBR, NADPH oxidase isoenzymes, and urinary 8-isoprostane, as well as renal NHE3 and NCC, and increased the renal expression of D1R but not D5R in D2-/- ..

More Information

Publications133 found, 100 shown here

  1. Wang L, Wang X, Qu H, Jiang S, Zhang J, Fu L, et al. Role of Kidneys in Sex Differences in Angiotensin II-Induced Hypertension. Hypertension. 2017;70:1219-1227 pubmed publisher
    ..II receptor, type 1), AT1R/AT2R, ET-1 (endothelin-1), ETA (endothelin receptor type A), NHE3 (sodium-hydrogen exchanger 3), α-ENaC (α-epithelial sodium channel), and γ-ENaC, were unaltered in same-..
  2. Meliopoulos V, Marvin S, Freiden P, Moser L, Nighot P, Ali R, et al. Oral Administration of Astrovirus Capsid Protein Is Sufficient To Induce Acute Diarrhea In Vivo. MBio. 2016;7: pubmed publisher
    ..changes but was associated with increased intestinal barrier permeability, as well as redistribution of sodium hydrogen exchanger 3 (NHE3) from the membrane to the cytoplasm of the intestinal epithelium...
  3. Lang F, Huang D, Vallon V. SGK, renal function and hypertension. J Nephrol. 2010;23 Suppl 16:S124-9 pubmed
    ..the activity of a variety of ion channels such as ENaC, TRPV5, ROMK, KCNE1/KCNQ1 and ClCKb; carriers such as NHE3, NKCC2, NCC and SGLT1; as well as the Na+/K+-ATPase...
  4. Satoh N, Nakamura M, Suzuki M, Suzuki A, Seki G, Horita S. Roles of Akt and SGK1 in the Regulation of Renal Tubular Transport. Biomed Res Int. 2015;2015:971697 pubmed publisher
    ..Moreover, sodium-proton exchanger 3 (NHE3) in proximal tubules is possibly activated by SGK1...
  5. Sabolic I, Ljubojevic M, Herak Kramberger C, Brown D. Cd-MT causes endocytosis of brush-border transporters in rat renal proximal tubules. Am J Physiol Renal Physiol. 2002;283:F1389-402 pubmed
    ..loss of microvilli; 2) time-dependent loss of megalin, V-ATPase, aquaporin-1 (AQP1), and type 3 Na+/H+ exchanger (NHE3) from the BBM; 3) redistribution of these transporters into vesicles that were randomly scattered throughout the ..
  6. Yao G, Hu S, Yu L, Ru Y, Chen C, Liu Q, et al. Genome-Wide Mapping of In Vivo ER?-Binding Sites in Male Mouse Efferent Ductules. Endocrinology. 2017;158:3724-3737 pubmed publisher
    ..Taken together, our study provides a useful reference set for future work aimed at exploring the mechanism of ER? action in physiological conditions...
  7. Forno E, Wang T, Qi C, Yan Q, Xu C, Boutaoui N, et al. DNA methylation in nasal epithelium, atopy, and atopic asthma in children: a genome-wide study. Lancet Respir Med. 2019;7:336-346 pubmed publisher
    ..Our findings support the feasibility of using the nasal methylome for future clinical applications, such as predicting the development of asthma among wheezing infants. US National Institutes of Health. ..
  8. Polsinelli V, Sinha A, Shah S. Visceral Congestion in Heart Failure: Right Ventricular Dysfunction, Splanchnic Hemodynamics, and the Intestinal Microenvironment. Curr Heart Fail Rep. 2017;14:519-528 pubmed publisher
    ..could result in (1) hypoxia and acidosis in enterocytes, which may lead to enhanced sodium-hydrogen exchanger 3 (NHE3) expression with increased sodium and fluid retention; (2) decreased luminal pH in the intestines, which could lead ..
  9. Xiao F, Jurić M, Li J, Riederer B, Yeruva S, Singh A, et al. Loss of downregulated in adenoma (DRA) impairs mucosal HCO3(-) secretion in murine ileocolonic inflammation. Inflamm Bowel Dis. 2012;18:101-11 pubmed publisher
    ..TNF(+/?ARE) ileocolon, whereas cystic fibrosis transmembrane conductance regulator (CFTR), Na(+) /H(+) exchanger 3 (NHE3), Na(+) /HCO(3)(-) cotransporter (NBC), and epithelial sodium channel (ENaC) expression was not significantly ..
  10. Lou Y, Zhang F, Luo Y, Wang L, Huang S, Jin F. Serum and Glucocorticoid Regulated Kinase 1 in Sodium Homeostasis. Int J Mol Sci. 2016;17: pubmed publisher
    ..5), sodium hydrogen exchangers 1 and 3 (NHE1 and NHE3), sodium-chloride symporter (NCC), and sodium-potassium-chloride cotransporter 2 (NKCC2); as well as the sodium-..
  11. Farah L, Valentini V, Pessoa T, Malnic G, McDonough A, Girardi A. The physiological role of glucagon-like peptide-1 in the regulation of renal function. Am J Physiol Renal Physiol. 2016;310:F123-7 pubmed publisher
    ..Exendin-9 infusion also reduced renal cortical Na(+)/H(+) exchanger isotope 3 (NHE3) phosphorylation at serine 552 (NHE3pS552), a PKA consensus site that correlates with reduced transport activity...
  12. Pavlov T, Levchenko V, Ilatovskaya D, Moreno C, Staruschenko A. Renal sodium transport in renin-deficient Dahl salt-sensitive rats. J Renin Angiotensin Aldosterone Syst. 2016;17: pubmed publisher
    ..Here we found that renin deficiency led to decreased expression of sodium-hydrogen antiporter (NHE3), the Na(+)/H(+) exchanger involved in Na(+) absorption in the proximal tubules, but did not affect the expression ..
  13. Yin L, Menon R, Gupta R, Vaught L, Okunieff P, Vidyasagar S. Glucose enhances rotavirus enterotoxin-induced intestinal chloride secretion. Pflugers Arch. 2017;469:1093-1105 pubmed publisher
    ..b>NHE3 activity increased, and chloride secretory activity decreased with age...
  14. Slawinska A, Plowiec A, Siwek M, Jaroszewski M, Bednarczyk M. Long-Term Transcriptomic Effects of Prebiotics and Synbiotics Delivered In Ovo in Broiler Chickens. PLoS ONE. 2016;11:e0168899 pubmed publisher
    ..This is likely due to its strong bifidogenic effect, which triggers proliferation of indigenous embryonic microflora in ovo, and indirectly influences gene expression regulation in host tissues, especially cecal tonsils. ..
  15. Chen Y, Wu S, Tian Y, Kong J. Phosphorylation and subcellular localization of Na+/H+ exchanger isoform 3 (NHE3) are associated with altered gallbladder absorptive function after formation of cholesterol gallstones. J Physiol Biochem. 2017;73:133-139 pubmed publisher
    ..We conclude that increased phosphorylation of NHE3 following gallstone formation leads to turnover of the exchanger, resulting in decreased gallbladder concentrating function. ..
  16. Wang Y, Pasparakis C, Mager E, Stieglitz J, Benetti D, Grosell M. Ontogeny of urea and ammonia transporters in mahi-mahi (Coryphaena hippurus) early life stages. Comp Biochem Physiol A Mol Integr Physiol. 2019;229:18-24 pubmed publisher
    ..transporters (Rhag, Rhbg, Rhcg1 and Rhcg2), as well as urea transporter (UT) and sodium hydrogen exchangers (NHE3 and NHE2) during mahi development...
  17. Kravtsov D, Ahsan M, Kumari V, Van IJzendoorn S, Reyes Mugica M, Kumar A, et al. Identification of intestinal ion transport defects in microvillus inclusion disease. Am J Physiol Gastrointest Liver Physiol. 2016;311:G142-55 pubmed publisher
    ..approaches to examine the distribution, expression, and function of the major BB ion transporters NHE3 (Na(+)), CFTR (Cl(-)), and SLC26A3 (DRA) (Cl(-)/HCO3 (-)) that control intestinal fluid transport...
  18. Ma L, Liu Y, Landry N, El Achkar T, Lieske J, Wu X. Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in transgenic mice causes progressive renal damage and hyperuricemia. PLoS ONE. 2017;12:e0186769 pubmed publisher
    ..and reabsorptive functions of NKCC2 and ROMK and secondary responses in proximal tubules by upregulating NHE3 and URAT1...
  19. Komnenov D, Levanovich P, Rossi N. Hypertension Associated with Fructose and High Salt: Renal and Sympathetic Mechanisms. Nutrients. 2019;11: pubmed publisher
    ..Several transporters, such as NHE3 and PAT1 are modulated in this milieu and play a crucial role in salt-sensitivity...
  20. Packer M. Role of the Sodium-Hydrogen Exchanger in Mediating the Renal Effects of Drugs Commonly Used in the Treatment of Type 2 Diabetes. Diabetes Obes Metab. 2017;: pubmed publisher
    ..demonstrates that many existing drugs that are commonly prescribed to patients with diabetes act on the NHE1 and NHE3 isoforms in the kidney...
  21. Che H, Ruan Y, Luo T, Chen M. [The regulation of Na+/H+ exchangers by Toll-like receptors under inflammation]. Sheng Li Xue Bao. 2018;70:521-530 pubmed
    ..The activation of TLR5 increases the activity of NHE3. The activity and/or expression of NHE3 in intestinal macrophages in colitis patients and model animals were ..
  22. Nguyen M, Han J, Ralph D, Veiras L, McDonough A. Short-term nonpressor angiotensin II infusion stimulates sodium transporters in proximal tubule and distal nephron. Physiol Rep. 2015;3: pubmed publisher
    ..The 3-day nonpressor AngII infusion significantly increased the abundance of PT Na(+)/H(+) exchanger 3 (NHE3), cortical TALH Na-K-2Cl cotransporter 2 (NKCC2), distal convoluted tubule (DCT) Na-Cl cotransporter (NCC), and ..
  23. Liu T, Konkalmatt P, Yang Y, Jose P. Gastrin decreases Na+,K+-ATPase activity via a PI 3-kinase- and PKC-dependent pathway in human renal proximal tubule cells. Am J Physiol Endocrinol Metab. 2016;310:E565-71 pubmed publisher
    ..Recently, we reported that gastrin induces NHE3 phosphorylation and internalization via phosphatidylinositol (PI) 3-kinase and PKCα...
  24. Hsu C, Lai W, Lin Y, Tain Y. Postnatal high-fat diet sex-specifically exacerbates prenatal dexamethasone-induced hypertension: Mass spectrometry-based quantitative proteomic approach. J Nutr Biochem. 2018;57:268-275 pubmed publisher
    ..Moreover, DEX?+?HF increased renal protein level of type 3 sodium hydrogen exchanger (NHE3) in males but not in females...
  25. Takei Y, Wong M, Pipil S, Ozaki H, Suzuki Y, Iwasaki W, et al. Molecular mechanisms underlying active desalination and low water permeability in the esophagus of eels acclimated to seawater. Am J Physiol Regul Integr Comp Physiol. 2017;312:R231-R244 pubmed publisher
    ..in eel esophagus detected by RNA-seq, dimethyl amiloride-sensitive Na+/H+ exchanger (NHE3) and 4,4'-diisothiocyano-2,2'-disulfonic acid-sensitive Cl-/[Formula: see text] exchanger (AE) coupled ..
  26. Tain Y, Lin Y, Chan J, Lee C, Hsu C. Maternal melatonin or agomelatine therapy prevents programmed hypertension in male offspring of mother exposed to continuous light. Biol Reprod. 2017;97:636-643 pubmed publisher
    ..Our data highlight candidate genes and pathways in renal programming as targets for therapeutic approaches to prevent programmed hypertension caused by early-life disturbance of the circadian rhythm. ..
  27. Dieho K, van Baal J, Kruijt L, Bannink A, Schonewille J, Carreno D, et al. Effect of supplemental concentrate during the dry period or early lactation on rumen epithelium gene and protein expression in dairy cattle during the transition period. J Dairy Sci. 2017;100:7227-7245 pubmed publisher
    ..In the dry period experiment, expression of MCT1, NBC1, DRA, NHE2, NHE3, and UT-B generally decreased after calving...
  28. Udwan K, Abed A, Roth I, Dizin E, Maillard M, Bettoni C, et al. Dietary sodium induces a redistribution of the tubular metabolic workload. J Physiol. 2017;595:6905-6922 pubmed publisher
    ..As expected, LSD did not alter measured GFR and increased the abundance of total and cell-surface NHE3, NKCC2, NCC, α-ENaC and cleaved γ-ENaC compared to NSD...
  29. Busque S, Stange G, Wagner C. Dysregulation of the glutamine transporter Slc38a3 (SNAT3) and ammoniagenic enzymes in obese, glucose-intolerant mice. Cell Physiol Biochem. 2014;34:575-89 pubmed publisher
    ..Ammonium excretion into the proximal tubule is mediated at least in part by the Na(+)/H(+)-exchanger NHE3 and in the collecting duct involving the Rhesus protein RhCG...
  30. Eiam Ong S, Chaipipat M, Manotham K, Eiam Ong S. Rapid Action of Aldosterone on Protein Levels of Sodium-Hydrogen Exchangers and Protein Kinase C Beta Isoforms in Rat Kidney. Int J Endocrinol. 2017;2017:2975853 pubmed publisher
    ..Aldosterone increased NHE1 and NHE3 protein abundance to 152% and 134%, respectively (P < 0.05)...
  31. Jantarajit W, Lertsuwan K, Teerapornpuntakit J, Krishnamra N, Charoenphandhu N. CFTR-mediated anion secretion across intestinal epithelium-like Caco-2 monolayer under PTH stimulation is dependent on intermediate conductance K+ channels. Am J Physiol Cell Physiol. 2017;313:C118-C129 pubmed publisher
    ..In conclusion, PTH requires NHE3 and basolateral K+ channels to induce [Formula: see text] and Cl- secretion, thus explaining ..
  32. Nejsum L, Kwon T, Marples D, Flyvbjerg A, Knepper M, Frøkiaer J, et al. Compensatory increase in AQP2, p-AQP2, and AQP3 expression in rats with diabetes mellitus. Am J Physiol Renal Physiol. 2001;280:F715-26 pubmed
    ..There was a marked increase in urinary sodium excretion in DM. Only Na(+)/H(+) exchanger NHE3 was downregulated (67 +/- 10 vs...
  33. Tain Y, Huang L, Lee C, Chan J, Hsu C. Maternal citrulline supplementation prevents prenatal N(G)-nitro-L-arginine-methyl ester (L-NAME)-induced programmed hypertension in rats. Biol Reprod. 2015;92:7 pubmed publisher
    ..the kidney, increased urinary cGMP levels, and decreased renal protein levels of type 3 sodium hydrogen exchanger (NHE3)...
  34. Xu H, McCoy A, Li J, Zhao Y, Ghishan F. Sodium butyrate stimulates NHE8 expression via its role on activating NHE8 basal promoter activity. Am J Physiol Gastrointest Liver Physiol. 2015;309:G500-5 pubmed publisher
    ..has been shown to stimulate electroneutral sodium absorption through its regulation on sodium/hydrogen exchanger 3 (NHE3)...
  35. Turner J, Black E, Ward J, Tse C, Uchwat F, Alli H, et al. Transepithelial resistance can be regulated by the intestinal brush-border Na(+)/H(+) exchanger NHE3. Am J Physiol Cell Physiol. 2000;279:C1918-24 pubmed
    ..Evaluation using multiple Na(+)/H(+) exchange inhibitors showed that inhibition of the Na(+)/H(+) exchanger 3 (NHE3) isoform was most closely related to TER increases...
  36. Zhu H, Sagnella G, Dong Y, Miller M, Onipinla A, Markandu N, et al. Molecular variants of the sodium/hydrogen exchanger type 3 gene and essential hypertension. J Hypertens. 2004;22:1269-75 pubmed
    ..this study were to identify polymorphic variants within the gene coding for the sodium/hydrogen exchanger type 3 (NHE3) and to examine their relationship with hypertension and biochemical indices of sodium balance...
  37. Liu M, Zhu Y, Sun Y, Wen Z, Huang S, Ding G, et al. MnTBAP therapy attenuates the downregulation of sodium transporters in obstructive kidney disease. Oncotarget. 2018;9:394-403 pubmed publisher
    ..Following unilateral ureteral obstruction (UUO) for 7 days, a global reduction of sodium transporters including NHE3, NCC, NKCC2, and ENaCα was observed as determined by qRT-PCR, Western Blotting or immunohistochemistry...
  38. Hihnala S, Kujala M, Toppari J, Kere J, Holmberg C, Hoglund P. Expression of SLC26A3, CFTR and NHE3 in the human male reproductive tract: role in male subfertility caused by congenital chloride diarrhoea. Mol Hum Reprod. 2006;12:107-11 pubmed
    ..with interacting proteins cystic fibrosis transmembrane conductance regulator (CFTR) and Na(+)/H(+) exchanger 3 (NHE3), was studied using immunohistochemistry in the testis (n = 2) and efferent ducts (ED) (n = 1) of patients with CLD ..
  39. Hatanaka M, Kaimori J, Yamamoto S, Matsui I, Hamano T, Takabatake Y, et al. Azilsartan Improves Salt Sensitivity by Modulating the Proximal Tubular Na+-H+ Exchanger-3 in Mice. PLoS ONE. 2016;11:e0147786 pubmed publisher
    ..Immunofluorescence and western blotting showed lower levels of Na+-H+ exchanger-3 (NHE3) protein (the major sodium transporter in renal proximal tubules) in the azilsartan group, but not in the ..
  40. Kumar A, Anbazhagan A, Coffing H, Chatterjee I, Priyamvada S, Gujral T, et al. Lactobacillus acidophilus counteracts inhibition of NHE3 and DRA expression and alleviates diarrheal phenotype in mice infected with Citrobacter rodentium. Am J Physiol Gastrointest Liver Physiol. 2016;311:G817-G826 pubmed publisher
    ..Intestinal epithelial luminal membrane NHE3 (Na+/H+ exchanger 3) and DRA (Down-Regulated in Adenoma; Cl-/HCO3-<..
  41. Yun C, Tse C, Nath S, Levine S, Brant S, Donowitz M. Mammalian Na+/H+ exchanger gene family: structure and function studies. Am J Physiol. 1995;269:G1-11 pubmed
    ..forms of the exchangers was demonstrated by the recent cloning of four mammalian Na+/H+ exchangers, NHE1, NHE2, NHE3, and NHE4...
  42. Yang J, Sarker R, Singh V, Sarker P, Yin J, Chen T, et al. The NHERF2 sequence adjacent and upstream of the ERM-binding domain affects NHERF2-ezrin binding and dexamethasone stimulated NHE3 activity. Biochem J. 2015;470:77-90 pubmed publisher
    ..Moreover, increased phosphorylation of Ser(303) was functionally significant preventing acute stimulation of NHE3 (Na(+)-H(+) exchanger 3) activity by dexamethasone.
  43. Guo Y, Liu Y, Liu M, Wang J, Xie Z, Chen K, et al. Na+/HCO3- Cotransporter NBCn2 Mediates HCO3- Reclamation in the Apical Membrane of Renal Proximal Tubules. J Am Soc Nephrol. 2017;28:2409-2419 pubmed publisher
    ..However, NHE3 and the proton pump cannot account for all HCO3- reclamation...
  44. Joly F, Mayeur C, Messing B, Lavergne Slove A, Cazals Hatem D, Noordine M, et al. Morphological adaptation with preserved proliferation/transporter content in the colon of patients with short bowel syndrome. Am J Physiol Gastrointest Liver Physiol. 2009;297:G116-23 pubmed publisher
    ..The proliferating and apoptotic cell contents were evaluated by revealing Ki67, PCNA, and caspase-3. NHE2, NHE3, PepT1 mRNAs, and PepT1 protein were quantified by quantitative RT-PCR and Western blot, respectively...
  45. Engevik M, Engevik K, Yacyshyn M, Wang J, Hassett D, Darien B, et al. Human Clostridium difficile infection: inhibition of NHE3 and microbiota profile. Am J Physiol Gastrointest Liver Physiol. 2015;308:G497-509 pubmed publisher
    ..In cell lines, C. difficile toxin B has been shown to inhibit Na(+)/H(+) exchanger 3 (NHE3) and loss of NHE3 in mice results in an altered intestinal environment coupled with a transformed gut microbiota ..
  46. Gibbons T, Rudman S, Schulte P. Responses to simulated winter conditions differ between threespine stickleback ecotypes. Mol Ecol. 2016;25:764-75 pubmed publisher
    ..growth (assessed as final mass) and the expression of an isoform of the electroneutral Na(+)/H(+) exchanger (NHE3) exhibited substantial change with temperature in the marine ecotype that was not observed in the freshwater ..
  47. Lee J, Lee Y, Kim J, Park H, Grinstein S, Orlowski J, et al. BetaPix up-regulates Na+/H+ exchanger 3 through a Shank2-mediated protein-protein interaction. J Biol Chem. 2010;285:8104-13 pubmed publisher
    Na(+)/H(+) exchanger 3 (NHE3) plays an important role in neutral Na(+) transport in mammalian epithelial cells...
  48. Avula L, Chen T, Kovbasnjuk O, Donowitz M. Both NHERF3 and NHERF2 are necessary for multiple aspects of acute regulation of NHE3 by elevated Ca2+, cGMP and lysophosphatidic acid. Am J Physiol Gastrointest Liver Physiol. 2017;:ajpgi.00140.2017 pubmed publisher
    The intestinal epithelial brush border Na+/H+ exchanger NHE3 accounts for a large component of intestinal Na absorption...
  49. Klinger S, Breves G. Resveratrol Inhibits Porcine Intestinal Glucose and Alanine Transport: Potential Roles of Na?/K?-ATPase Activity, Protein Kinase A, AMP-Activated Protein Kinase and the Association of Selected Nutrient Transport Proteins with Detergent Resistant Memb. Nutrients. 2018;10: pubmed publisher
    ..The DRM association of SGLT1, peptide transporter 1 (PEPT1) and (phosphorylated) Na?/H?-exchanger 3 (NHE3) did not change...
  50. Turner J, Black E. NHE3-dependent cytoplasmic alkalinization is triggered by Na(+)-glucose cotransport in intestinal epithelia. Am J Physiol Cell Physiol. 2001;281:C1533-41 pubmed
    ..S-3226, a preferential inhibitor of Na(+)/H(+) exchanger (NHE) isoform 3 (NHE3), prevented cytoplasmic alkalinization after initiation of Na(+)-glucose cotransport with an ED(50) of 0...
  51. Musch M, Lucioni A, Chang E. Aldosterone regulation of intestinal Na absorption involves SGK-mediated changes in NHE3 and Na+ pump activity. Am J Physiol Gastrointest Liver Physiol. 2008;295:G909-19 pubmed publisher
    ..inhibition of the early increase in aldosterone-induced Na(+)-K(+)-ATPase activation blocked most of the apical NHE3 insertion, possibly by inhibiting Na(+)-K(+)-ATPase-induced changes in intracellular sodium concentration ([Na](i))...
  52. Babich V, Di Sole F. The Na+/H+ Exchanger-3 (NHE3) Activity Requires Ezrin Binding to Phosphoinositide and Its Phosphorylation. PLoS ONE. 2015;10:e0129306 pubmed publisher
    Na+/H+ exchanger-3 (NHE3) plays an essential role in maintaining sodium and fluid homeostasis in the intestine and kidney epithelium. Thus, NHE3 is highly regulated and its function depends on binding to multiple regulatory proteins...
  53. He P, Zhao L, Zhu L, Weinman E, De Giorgio R, Koval M, et al. Restoration of Na+/H+ exchanger NHE3-containing macrocomplexes ameliorates diabetes-associated fluid loss. J Clin Invest. 2015;125:3519-31 pubmed publisher
    ..We found that the expression of Na+/H+ exchanger NHE3 and several scaffold proteins, including NHE3 regulatory factors (NHERFs), inositol trisphosphate (IP₃) ..
  54. Alexander R, Dimke H. Effect of diuretics on renal tubular transport of calcium and magnesium. Am J Physiol Renal Physiol. 2017;312:F998-F1015 pubmed publisher
    ..Acetazolamide, osmotic diuretics, Na+/H+ exchanger (NHE3) inhibitors, and antidiabetic Na+/glucose cotransporter type 2 (SGLT) blocking compounds, target the ..
  55. Fenton R, Poulsen S, de la Mora Chavez S, Soleimani M, Dominguez Rieg J, Rieg T. Renal tubular NHE3 is required in the maintenance of water and sodium chloride homeostasis. Kidney Int. 2017;92:397-414 pubmed publisher
    The sodium/proton exchanger isoform 3 (NHE3) is expressed in the intestine and the kidney, where it facilitates sodium (re)absorption and proton secretion...
  56. Rosenbaum D, Yan A, Jacobs J. Pharmacodynamics, Safety, and Tolerability of the NHE3 Inhibitor Tenapanor: Two Trials in Healthy Volunteers. Clin Drug Investig. 2018;38:341-351 pubmed publisher
    Tenapanor, a small molecule with minimal systemic availability, is a first-in-class sodium/hydrogen exchanger 3 (NHE3) inhibitor that acts in the gut. Here, we evaluate the pharmacodynamics and safety of tenapanor in healthy adults...
  57. Ledoussal C, Lorenz J, Nieman M, Soleimani M, Schultheis P, Shull G. Renal salt wasting in mice lacking NHE3 Na+/H+ exchanger but not in mice lacking NHE2. Am J Physiol Renal Physiol. 2001;281:F718-27 pubmed
    To study the role of Na+/H+ exchanger isoform 2 (NHE2) and isoform 3 (NHE3) in sodium-fluid volume homeostasis and renal Na+ conservation, mice with Nhe2 (Nhe2-/-) and/or Nhe3 (Nhe3-/-) null mutations were fed a Na+-restricted diet, and ..
  58. Han W, Kim K, Jo M, Lee J, Yang J, Doctor R, et al. Shank2 associates with and regulates Na+/H+ exchanger 3. J Biol Chem. 2006;281:1461-9 pubmed
    Na+/H+ exchanger 3 (NHE3) plays a pivotal role in transepithelial Na+ and HCO3(-) absorption across a wide range of epithelia in the digestive and renal-genitourinary systems...
  59. Zielińska M, Wasilewski A, Fichna J. Tenapanor hydrochloride for the treatment of constipation-predominant irritable bowel syndrome. Expert Opin Investig Drugs. 2015;24:1093-9 pubmed publisher
    ..Tenapanor is a potent inhibitor of Na(+)/H(+) exchanger 3 [NHE3], localized in the apical membrane of intestinal epithelial cells...
  60. Boudour Boucheker N, Boulo V, Charmantier Daures M, Anger K, Charmantier G, Lorin Nebel C. Osmoregulation in larvae and juveniles of two recently separated Macrobrachium species: Expression patterns of ion transporter genes. Comp Biochem Physiol A Mol Integr Physiol. 2016;195:39-45 pubmed publisher
    ..We therefore investigated the expression patterns of three ion transporters (NKA α-subunit, VHA B-subunit and NHE3) following differential salinity acclimation in different ontogenetic stages (stage-V larvae, juveniles) of both ..
  61. Shawki A, Engevik M, Kim R, Knight P, Baik R, Anthony S, et al. Intestinal brush-border Na+/H+ exchanger-3 drives H+-coupled iron absorption in the mouse. Am J Physiol Gastrointest Liver Physiol. 2016;311:G423-30 pubmed publisher
    ..exchanger (NHE) isoforms by examining iron homeostasis and intestinal iron handling in mice lacking NHE2 or NHE3. We observed modestly depleted liver iron stores in NHE2-null (NHE2(-/-)) mice stressed on a low-iron diet but no ..
  62. Shiue H, Musch M, Wang Y, Chang E, Turner J. Akt2 phosphorylates ezrin to trigger NHE3 translocation and activation. J Biol Chem. 2005;280:1688-95 pubmed
    Initiation of Na(+)-glucose cotransport in intestinal absorptive epithelia causes NHE3 to be translocated to the apical plasma membrane, leading to cytoplasmic alkalinization...
  63. Liu H, Ma Y, He H, Wang J, Jiang J, Shao R. SLC9A3R1 stimulates autophagy via BECN1 stabilization in breast cancer cells. Autophagy. 2015;11:2323-34 pubmed publisher
    ..SLC9A3R1 (solute carrier family 9, subfamily A [NHE3, cation proton antiporter 3], member 3 regulator 1), a multifunctional scaffold protein, is involved in suppressing ..
  64. He P, Zhao L, No Y, Karvar S, Yun C. The NHERF1 PDZ1 domain and IRBIT interact and mediate the activation of Na+/H+ exchanger 3 by ANG II. Am J Physiol Renal Physiol. 2016;311:F343-51 pubmed publisher
    ..receptor-binding protein released with inositol 1,4,5-trisphosphate (IRBIT) mediates ANG II-induced exocytosis of NHE3 in cultured proximal tubule epithelial cells...
  65. Hashimoto H, Nomura N, Shoda W, Isobe K, Kikuchi H, Yamamoto K, et al. Metformin increases urinary sodium excretion by reducing phosphorylation of the sodium-chloride cotransporter. Metabolism. 2018;85:23-31 pubmed publisher
    ..The activity of other renal sodium transporters, such as NKCC2, ENaC, and NHE3 did not show significant changes...
  66. Dietrich V, Szpilbarg N, Damiano A. Reduced expression of Na?/H? exchanger isoform 3 (NHE-3) in preeclamptic placentas. Placenta. 2013;34:828-30 pubmed publisher
    ..Further studies are needed to define whether these alterations play a direct role either in the pathogenesis or in the adaptative response of preeclampsia. ..
  67. Zhang Y, Sun Y, Ding G, Huang S, Zhang A, Jia Z. Inhibition of Mitochondrial Complex-1 Prevents the Downregulation of NKCC2 and ENaCα in Obstructive Kidney Disease. Sci Rep. 2015;5:12480 pubmed publisher
    ..Following unilateral ureteral obstruction (UUO) for 7 days, a global reduction of sodium transporters, including NHE3, α-Na-K-ATPase, NCC, NKCC2, p-NKCC2, ENaCα, and ENaCγ, was observed, as determined via qRT-PCR and/or ..
  68. Shenolikar S, Weinman E. NHERF: targeting and trafficking membrane proteins. Am J Physiol Renal Physiol. 2001;280:F389-95 pubmed
    Vectorial ion transport initiated by Na+/H+ exchanger isoform 3 (NHE3) mediates the reabsorption of NaCl and NaHCO(3) in renal proximal tubule cells. NHE3 activity is modulated by numerous physiological stimuli...
  69. Lee S, Seok Y, Jung H, Oh B, Lee H, Kwon S, et al. Expression of mRNA transcripts of the Na+/H+ and Cl-/HCO3- exchanger isoforms in human nasal mucosa. Acta Otolaryngol. 2002;122:866-71 pubmed
    ..The mRNA for NHE1 was detected in human turbinate mucosa and nasal polyp while the mRNAs for NHE2 and NHE3 could not be detected in any of the samples examined...
  70. Trujillo E, Alvarez de la Rosa D, Mobasheri A, Gonzalez T, Canessa C, Martin Vasallo P. Sodium transport systems in human chondrocytes. II. Expression of ENaC, Na+/K+/2Cl- cotransporter and Na+/H+ exchangers in healthy and arthritic chondrocytes. Histol Histopathol. 1999;14:1023-31 pubmed publisher
    ..Human chondrocytes also possess three isoforms of the Na+/H+ exchanger (NHE), NHE1, NHE2 and NHE3. The NHE system is composed of a single protein and is believed to participate in intracellular pH regulation...
  71. Yoo B, He P, Lee S, Yun C. Lysophosphatidic acid 5 receptor induces activation of Na(+)/H(+) exchanger 3 via apical epidermal growth factor receptor in intestinal epithelial cells. Am J Physiol Cell Physiol. 2011;301:C1008-16 pubmed publisher
    ..fluid absorption in human intestinal epithelial cells and mouse intestine by stimulation of Na(+)/H(+) exchanger 3 (NHE3) via LPA(5) receptor...
  72. Briffa J, Grinfeld E, Poronnik P, McAinch A, Hryciw D. Uptake of leptin and albumin via separate pathways in proximal tubule cells. Int J Biochem Cell Biol. 2016;79:194-198 pubmed publisher
    ..In OK cells, acute exposure to leptin for 2h did not alter NHE3, ClC-5, NHERF1 and NHERF2 mRNA...
  73. Dominguez Rieg J, de la Mora Chavez S, Rieg T. Novel developments in differentiating the role of renal and intestinal sodium hydrogen exchanger 3. Am J Physiol Regul Integr Comp Physiol. 2016;311:R1186-R1191 pubmed publisher
    The Na+/H+ exchanger isoform 3 (NHE3) facilitates Na+ absorption and H+ secretion and is expressed in the intestine, proximal tubule, and thick ascending limb of the kidney...
  74. Weinman E, Minkoff C, Shenolikar S. Signal complex regulation of renal transport proteins: NHERF and regulation of NHE3 by PKA. Am J Physiol Renal Physiol. 2000;279:F393-9 pubmed
    The activity of the sodium/hydrogen exchanger 3 (NHE3) isoform of the sodium/hydrogen exchanger in the brush-border membrane of the renal proximal tubule is tightly regulated...
  75. Kennedy D, Leibach F, Ganapathy V, Thwaites D. Optimal absorptive transport of the dipeptide glycylsarcosine is dependent on functional Na+/H+ exchange activity. Pflugers Arch. 2002;445:139-46 pubmed
    ..is dependent on the existence of a pH gradient (maintained, in part, by the action of the Na(+)/H(+) exchanger NHE3) across the apical membrane of the small intestinal epithelium...
  76. Yeruva S, Chodisetti G, Luo M, Chen M, Cinar A, Ludolph L, et al. Evidence for a causal link between adaptor protein PDZK1 downregulation and Na⁺/H⁺ exchanger NHE3 dysfunction in human and murine colitis. Pflugers Arch. 2015;467:1795-807 pubmed publisher
    A dysfunction of the Na(+)/H(+) exchanger isoform 3 (NHE3) significantly contributes to the reduced salt absorptive capacity of the inflamed intestine...
  77. Mennone A, Biemesderfer D, Negoianu D, Yang C, Abbiati T, Schultheis P, et al. Role of sodium/hydrogen exchanger isoform NHE3 in fluid secretion and absorption in mouse and rat cholangiocytes. Am J Physiol Gastrointest Liver Physiol. 2001;280:G247-54 pubmed
    ..The isoform NHE3 has been localized to apical surfaces of epithelia and in some tissues may facilitate the absorption of NaCl...
  78. Wang T, Hropot M, Aronson P, Giebisch G. Role of NHE isoforms in mediating bicarbonate reabsorption along the nephron. Am J Physiol Renal Physiol. 2001;281:F1117-22 pubmed
    This study assessed the functional role of Na(+)/H(+) exchanger (NHE) isoforms NHE3 and NHE2 in the proximal tubule, loop of Henle, and distal convoluted tubule of the rat kidney by comparing sensitivity of transport to inhibition by Hoe-..
  79. Kira R, Ishizaki Y, Torisu H, Sanefuji M, Takemoto M, Sakamoto K, et al. Genetic susceptibility to febrile seizures: case-control association studies. Brain Dev. 2010;32:57-63 pubmed publisher
    ..003). These data suggest that cytokine genes may act as enhancers or attenuators of FS susceptibility. Genetic association study may be an effective approach to understanding the molecular basis of FS at least in a subgroup of patients. ..
  80. Singh V, Lin R, Yang J, Cha B, Sarker R, Tse C, et al. AKT and GSK-3 are necessary for direct ezrin binding to NHE3 as part of a C-terminal stimulatory complex: role of a novel Ser-rich NHE3 C-terminal motif in NHE3 activity and trafficking. J Biol Chem. 2014;289:5449-61 pubmed publisher
    Basal activity of the BB Na(+)/H(+) exchanger NHE3 requires multiprotein complexes that form on its C terminus...
  81. Ozkucur N, Song B, Bola S, Zhang L, Reid B, Fu G, et al. NHE3 phosphorylation via PKC? marks the polarity and orientation of directionally migrating cells. Cell Mol Life Sci. 2014;71:4653-4663 pubmed publisher
    ..Because protein kinase C (PKC) is required in electrotaxis, we asked whether NHE3 is activated by PKC during wound healing...
  82. Solocinski K, Richards J, All S, Cheng K, Khundmiri S, Gumz M. Transcriptional regulation of NHE3 and SGLT1 by the circadian clock protein Per1 in proximal tubule cells. Am J Physiol Renal Physiol. 2015;309:F933-42 pubmed publisher
    ..Previous work has demonstrated that expression of Na(+)/H(+) exchanger 3 (NHE3) oscillates with a circadian pattern and Na(+)-glucose cotransporter (SGLT)1 has been demonstrated to be a ..
  83. Malakooti J, Sandoval R, Amin M, Clark J, Dudeja P, Ramaswamy K. Transcriptional stimulation of the human NHE3 promoter activity by PMA: PKC independence and involvement of the transcription factor EGR-1. Biochem J. 2006;396:327-36 pubmed
    b>NHE3 (Na+/H+ exchanger 3) is essential for Na+ absorption in the ileum and is expressed in a cell-specific manner in the apical membrane of the intestinal epithelial cells...
  84. Wang D, Zhang H, Lang F, Yun C. Acute activation of NHE3 by dexamethasone correlates with activation of SGK1 and requires a functional glucocorticoid receptor. Am J Physiol Cell Physiol. 2007;292:C396-404 pubmed
    ..stimulate the intestinal absorption of Na(+) and water partly by regulation of the Na(+)/H(+) exchanger 3 (NHE3). Previous studies have shown both genomic and nongenomic regulation of NHE3 by glucocorticoids...
  85. Malakooti J, Memark V, Dudeja P, Ramaswamy K. Molecular cloning and functional analysis of the human Na(+)/H(+) exchanger NHE3 promoter. Am J Physiol Gastrointest Liver Physiol. 2002;282:G491-500 pubmed
    Na(+)/H(+) exchanger (NHE) isoforms NHE2 and NHE3, colocalized to the brush border membrane of the epithelial cells, exhibit differences in their pattern of tissue expression and regulation by various molecular signals...
  86. Amin M, Malakooti J, Sandoval R, Dudeja P, Ramaswamy K. IFN-gamma and TNF-alpha regulate human NHE3 gene expression by modulating the Sp family transcription factors in human intestinal epithelial cell line C2BBe1. Am J Physiol Cell Physiol. 2006;291:C887-96 pubmed
    ..IFN-gamma and TNF-alpha, which have been shown to downregulate the expression of the sodium-hydrogen exchanger-3 (NHE3) gene...
  87. Fonseca Camarillo G, Yamamoto Furusho J. Gene expression of solute carrier family 9 (sodium/hydrogen exchanger) 3, (SLC9A3) is downregulated in patients with ulcerative colitis. Inflamm Bowel Dis. 2012;18:1197-8 pubmed publisher
  88. Pereira S, Ribeiro J, Bertuzzo C, Marson F. Association of clinical severity of cystic fibrosis with variants in the SLC gene family (SLC6A14, SLC26A9, SLC11A1 and SLC9A3). Gene. 2017;629:117-126 pubmed publisher
    ..085-10.24); (viii) rs17563161*GG with lowest age for onset of digestive symptoms (OR=2.564; 95%CI=1.234-5.33). The clinical and laboratory variability of CF were associated with the variants in the genes of SLC family in our sample. ..
  89. Hu M, Bobulescu I, QUINONES H, Gisler S, Moe O. Dopamine reduces cell surface Na+/H+ exchanger-3 protein by decreasing NHE3 exocytosis and cell membrane recycling. Am J Physiol Renal Physiol. 2017;313:F1018-F1025 pubmed publisher
    ..transporters to effect sodium excretion, including the proximal tubule Na+/H+ exchanger-3 (NHE3)...
  90. Ledoussal C, Woo A, Miller M, Shull G. Loss of the NHE2 Na(+)/H(+) exchanger has no apparent effect on diarrheal state of NHE3-deficient mice. Am J Physiol Gastrointest Liver Physiol. 2001;281:G1385-96 pubmed
    The expression of NHE2 and NHE3 on intestinal-brush border membranes suggests that both Na(+)/H(+) exchangers serve absorptive functions...
  91. Muthusamy S, Jeong J, Cheng M, Bonzo J, Kumar A, Gonzalez F, et al. Hepatocyte Nuclear Factor 4? Regulates the Expression of Intestinal Epithelial Na+/H+ Exchanger Isoform-3 (NHE3). Am J Physiol Gastrointest Liver Physiol. 2017;:ajpgi.00225.2017 pubmed publisher
    ..Reduced NHE3 expression or function has been implicated in the pathogenesis of diarrhea associated with IBD or enteric ..
  92. Yang J, Singh V, Cha B, Chen T, Sarker R, Murtazina R, et al. NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells. J Biol Chem. 2013;288:16960-74 pubmed publisher
    ..In addition, this NHERF2 domain was functionally significant in NHE3 regulation, being necessary for stimulation by lysophosphatidic acid of activity and increased mobility of NHE3, as ..