NGF

Summary

Gene Symbol: NGF
Description: nerve growth factor
Alias: Beta-NGF, HSAN5, NGFB, beta-nerve growth factor, nerve growth factor (beta polypeptide), nerve growth factor, beta subunit
Species: human
Products:     NGF

Top Publications

  1. Mercader J, Saus E, Aguera Z, Bayés M, Boni C, Carreras A, et al. Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders. Hum Mol Genet. 2008;17:1234-44 pubmed publisher
    ..We have performed a family-based association study with 151 TagSNPs covering 10 neurotrophin signaling genes: NGFB, BDNF, NTRK1, NGFR/p75, NTF4/5, NTRK2, NTF3, NTRK3, CNTF and CNTFR in 371 ED trios of Spanish, French and German ..
  2. Sanico A, Stanisz A, Gleeson T, Bora S, Proud D, Bienenstock J, et al. Nerve growth factor expression and release in allergic inflammatory disease of the upper airways. Am J Respir Crit Care Med. 2000;161:1631-5 pubmed
    ..We thus hypothesized that nerve growth factor (NGF), which is expressed by inflammatory cells and effects changes that lead to increased neural responsiveness, could ..
  3. Jiang Y, Liu H, Kuo H. Decrease of urinary nerve growth factor but not brain-derived neurotrophic factor in patients with interstitial cystitis/bladder pain syndrome treated with hyaluronic acid. PLoS ONE. 2014;9:e91609 pubmed publisher
    To investigate urinary nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) levels in interstitial cystitis/bladder pain syndrome (IC/BPS) patients after hyaluronic acid (HA) therapy...
  4. Liu H, Kuo H. Increased urine and serum nerve growth factor levels in interstitial cystitis suggest chronic inflammation is involved in the pathogenesis of disease. PLoS ONE. 2012;7:e44687 pubmed publisher
    ..This study investigated the nerve growth factor (NGF) levels in serum and urine in patients with IC/BPS...
  5. Fauchais A, Boumediene A, Lalloue F, Gondran G, Loustaud Ratti V, Vidal E, et al. Brain-derived neurotrophic factor and nerve growth factor correlate with T-cell activation in primary Sjogren's syndrome. Scand J Rheumatol. 2009;38:50-7 pubmed publisher
    ..Samples from 18 pSS patients and 12 control subjects were studied to determine serum levels of nerve-growth factor (NGF) and brain-derived neurotrophic factor (BDNF), and their relationships with T- and B-cell activation and disease ..
  6. Lee B, Chul B, Choi I, Kim Y, Ham B, Yang B, et al. Relation between plasma brain-derived neurotrophic factor and nerve growth factor in the male patients with alcohol dependence. Alcohol. 2009;43:265-9 pubmed publisher
    Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are thought to be related to neuroprotection in cell culture and animal studies...
  7. Adriaenssens E, Vanhecke E, Saule P, Mougel A, Page A, Romon R, et al. Nerve growth factor is a potential therapeutic target in breast cancer. Cancer Res. 2008;68:346-51 pubmed publisher
    We show here that nerve growth factor (NGF), the prototypic neurotrophin, can be targeted in breast cancer to inhibit tumor cell proliferation, survival, and metastasis...
  8. Sigala S, Bodei S, Missale C, Zani D, Simeone C, Cunico S, et al. Gene expression profile of prostate cancer cell lines: effect of nerve growth factor treatment. Mol Cell Endocrinol. 2008;284:11-20 pubmed publisher
    A dysregulation of the nerve growth factor (NGF)-mediated control of prostate cell growth is associated with the malignant progression of prostate epithelial cells...
  9. Lang U, Hellweg R, Bajbouj M, Gaus V, Sander T, Gallinat J. Gender-dependent association of a functional NGF polymorphism with anxiety-related personality traits. Pharmacopsychiatry. 2008;41:196-9 pubmed publisher
    Nerve growth factor (NGF) has been shown to be involved in anxiety behaviour and the expression of conditioned fear in mice. We have tested a total of 337 (age: 39.2 +/- 14...

More Information

Publications82

  1. He X, Garcia K. Structure of nerve growth factor complexed with the shared neurotrophin receptor p75. Science. 2004;304:870-5 pubmed
    ..We have determined the 2.4 A crystal structure of the prototypic neurotrophin, nerve growth factor (NGF), complexed with the extracellular domain of p75...
  2. Larsson E, Kuma R, Norberg A, Minde J, Holmberg M. Nerve growth factor R221W responsible for insensitivity to pain is defectively processed and accumulates as proNGF. Neurobiol Dis. 2009;33:221-8 pubmed publisher
    We have previously identified a homozygous missense (R221W) mutation in the NGFB gene in patients with loss of deep pain perception...
  3. Fitzgibbon G, Kingston H, Needham M, Gaunt L. Haploinsufficiency of the nerve growth factor beta gene in a 1p13 deleted female child with an insensitivity to pain. Dev Med Child Neurol. 2009;51:833-7 pubmed publisher
    ..The human nerve growth factor beta gene (NGFB) located on chromosome 1p13...
  4. Dissen G, Garcia Rudaz C, Paredes A, Mayer C, Mayerhofer A, Ojeda S. Excessive ovarian production of nerve growth factor facilitates development of cystic ovarian morphology in mice and is a feature of polycystic ovarian syndrome in humans. Endocrinology. 2009;150:2906-14 pubmed publisher
    Although ovarian nerve growth factor (NGF) facilitates follicular development and ovulation, an excess of the neurotrophin in the rodent ovary reduces ovulatory capacity and causes development of precystic follicles...
  5. Huang E, Reichardt L. Trk receptors: roles in neuronal signal transduction. Annu Rev Biochem. 2003;72:609-42 pubmed
    ..receptor tyrosine kinases, each of which can be activated by one or more of four neurotrophins-nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophins 3 and 4 (NT3 and NT4)...
  6. Richardson S, Doyle P, Minogue B, Gnanalingham K, Hoyland J. Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc. Arthritis Res Ther. 2009;11:R126 pubmed publisher
    ..pro-inflammatory cytokines interleukin-1 (IL-1) and tumour necrosis factor-alpha (TNF-alpha), nerve growth factor (NGF) and the pain-associated neuropeptide substance P were also analysed...
  7. Yamauchi K, Inoue G, Koshi T, Yamashita M, Ito T, Suzuki M, et al. Nerve growth factor of cultured medium extracted from human degenerative nucleus pulposus promotes sensory nerve growth and induces substance p in vitro. Spine (Phila Pa 1976). 2009;34:2263-9 pubmed publisher
    ..The average length of growing axons in the NP was significantly shortened after anti-nerve growth factor (NGF)beta treatment (P < 0.005); however, that in the AF was not (P > 0.05)...
  8. Kaplan D, Miller F. Signal transduction by the neurotrophin receptors. Curr Opin Cell Biol. 1997;9:213-21 pubmed
    ..These differing responses point to a complex interplay between neurotrophin-stimulated survival, differentiation, and apoptosis pathways. ..
  9. Othumpangat S, Gibson L, Samsell L, Piedimonte G. NGF is an essential survival factor for bronchial epithelial cells during respiratory syncytial virus infection. PLoS ONE. 2009;4:e6444 pubmed publisher
    ..Expression of neurotrophic factors (nerve growth factor, NGF; brain-derived neurotrophic factor, BDNF) and receptors (trkA, trkB, p75) was analyzed at the protein level by ..
  10. Minde J, Andersson T, Fulford M, Aguirre M, Nennesmo I, Remahl I, et al. A novel NGFB point mutation: a phenotype study of heterozygous patients. J Neurol Neurosurg Psychiatry. 2009;80:188-95 pubmed publisher
    ..to hereditary sensory and autonomic neuropathy type V having a point mutation in the nerve growth factor beta (NGFB) gene was recently described. The homozygous genotype gives disabling symptoms...
  11. Meloni M, Caporali A, Graiani G, Lagrasta C, Katare R, Van Linthout S, et al. Nerve growth factor promotes cardiac repair following myocardial infarction. Circ Res. 2010;106:1275-84 pubmed publisher
    Nerve growth factor (NGF) promotes angiogenesis and cardiomyocyte survival, which are both desirable for postinfarction myocardial healing. Nonetheless, the NGF potential for cardiac repair has never been investigated...
  12. Wiesmann C, Ultsch M, Bass S, de Vos A. Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor. Nature. 1999;401:184-8 pubmed
    Nerve growth factor (NGF) is involved in a variety of processes involving signalling, such as cell differentiation and survival, growth cessation and apoptosis of neurons...
  13. Liu H, Kuo H. Intravesical botulinum toxin A injections plus hydrodistension can reduce nerve growth factor production and control bladder pain in interstitial cystitis. Urology. 2007;70:463-8 pubmed
    To investigate the level of nerve growth factor (NGF) mRNA in bladder tissue and the effect of botulinum toxin A (BTX-A) treatment in patients with interstitial cystitis (IC).
  14. Lee R, Kermani P, Teng K, Hempstead B. Regulation of cell survival by secreted proneurotrophins. Science. 2001;294:1945-8 pubmed
    ..proneurotrophins have been considered inactive precursors, we show here that the proforms of nerve growth factor (NGF) and the proforms of brain derived neurotrophic factor (BDNF) are secreted and cleaved extracellularly by the ..
  15. Reichardt L. Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci. 2006;361:1545-64 pubmed
  16. Kobayashi H, Gleich G, Butterfield J, Kita H. Human eosinophils produce neurotrophins and secrete nerve growth factor on immunologic stimuli. Blood. 2002;99:2214-20 pubmed
    Neurotrophins, such as nerve growth factor (NGF) and neurotrophin-3 (NT-3), are essential for development, function, and survival of peripheral sympathetic and sensory neurons...
  17. Chaldakov G, Fiore M, Stankulov I, Hristova M, Antonelli A, Manni L, et al. NGF, BDNF, leptin, and mast cells in human coronary atherosclerosis and metabolic syndrome. Arch Physiol Biochem. 2001;109:357-60 pubmed
    ..implicated in cardiovascular tissue development and in lipid and glucose metabolism, the role of the neurotrophins NGF and BDNF and also the adipokine leptin in human coronary atherosclerosis and related disorders, such as metabolic ..
  18. Aalto K, Korhonen L, Lahdenne P, Pelkonen P, Lindholm D. Nerve growth factor in serum of children with systemic lupus erythematosus is correlated with disease activity. Cytokine. 2002;20:136-9 pubmed
    Nerve growth factor (NGF) is a neurotrophic factor, which is expressed both in the nervous system and in peripheral organs...
  19. Rotthier A, Baets J, De Vriendt E, Jacobs A, Auer Grumbach M, Levy N, et al. Genes for hereditary sensory and autonomic neuropathies: a genotype-phenotype correlation. Brain. 2009;132:2699-711 pubmed publisher
    ..for autosomal dominant (SPTLC1 and RAB7) and five genes for autosomal recessive forms of HSAN (WNK1/HSN2, NTRK1, NGFB, CCT5 and IKBKAP)...
  20. Sornelli F, Lambiase A, Mantelli F, Aloe L. NGF and NGF-receptor expression of cultured immortalized human corneal endothelial cells. Mol Vis. 2010;16:1439-47 pubmed
    Several growth factors, including nerve growth factor (NGF) and vascular endothelial growth factor (VEGF), play an important role in the homeostasis of the ocular surface...
  21. Xu L, Liu C, Gao G, Yu X, Zhang R, Wang J. Nerve growth factor-beta expression is associated with lymph node metastasis and nerve infiltration in human hilar cholangiocarcinoma. World J Surg. 2010;34:1039-45 pubmed publisher
    ..Previous studies have shown that nerve growth factor-beta (NGF-beta) can promote the initiation and progression of many tumors...
  22. Covaceuszach S, Capsoni S, Marinelli S, Pavone F, Ceci M, Ugolini G, et al. In vitro receptor binding properties of a "painless" NGF mutein, linked to hereditary sensory autonomic neuropathy type V. Biochem Biophys Res Commun. 2010;391:824-9 pubmed publisher
    ..Recently, a missense point mutation was found in the NGFB gene (C661T, leading to the aminoacid substitution R100W) of individuals affected by a form of hereditary loss of ..
  23. Barthel C, Yeremenko N, Jacobs R, Schmidt R, Bernateck M, Zeidler H, et al. Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis. Arthritis Res Ther. 2009;11:R82 pubmed publisher
    ..we investigated the presence of the corresponding nerve growth factors, with special focus on nerve growth factor (NGF)...
  24. Alam M, Pravica V, Fryer A, Hawkins C, Hutchinson I. Novel polymorphism in the promoter region of the human nerve growth-factor gene. Int J Immunogenet. 2005;32:379-82 pubmed
    ..We describe a novel T to C transition at position -198 from the transcription start of the human nerve growth-factor (NGF) gene. In British Caucasoid healthy control group that we have genotyped, T and C allele frequencies are 0...
  25. Purmessur D, Freemont A, Hoyland J. Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc. Arthritis Res Ther. 2008;10:R99 pubmed publisher
    The neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) have been identified in the human intervertebral disc (IVD) and have been implicated in the mechanisms associated with nerve ingrowth and ..
  26. Nykjaer A, Willnow T, Petersen C. p75NTR--live or let die. Curr Opin Neurobiol. 2005;15:49-57 pubmed
    ..Here, we review recent progress in delineating the molecular networks that enable p75(NTR) to dictate life and death. ..
  27. Pedraza C, Podlesniy P, Vidal N, Arevalo J, Lee R, Hempstead B, et al. Pro-NGF isolated from the human brain affected by Alzheimer's disease induces neuronal apoptosis mediated by p75NTR. Am J Pathol. 2005;166:533-43 pubmed
    The pro-form of nerve growth factor (pro-NGF) has been shown to be a high affinity ligand for p75NTR and to induce apoptosis through this receptor...
  28. Nykjaer A, Lee R, Teng K, Jansen P, Madsen P, Nielsen M, et al. Sortilin is essential for proNGF-induced neuronal cell death. Nature. 2004;427:843-8 pubmed
    ..Sortilin is expressed during embryogenesis in areas where nerve growth factor (NGF) and its precursor, proNGF, have well-characterized effects...
  29. Frank P, Barrientos G, Tirado Gonzalez I, Cohen M, Moschansky P, Peters E, et al. Balanced levels of nerve growth factor are required for normal pregnancy progression. Reproduction. 2014;148:179-89 pubmed publisher
    Nerve growth factor (NGF), the first identified member of the family of neurotrophins, is thought to play a critical role in the initiation of the decidual response in stress-challenged pregnant mice...
  30. Jee D, Lee W. Inhibitory effect of intravitreal injection of bevacizumab on nerve growth factor. Curr Eye Res. 2012;37:408-15 pubmed publisher
    ..the inhibitory effect of intravitreal injection of bevacizumab on the expression of nerve growth factor (NGF) in rabbit retina. The right eyes of 40 New Zealand white rabbits were injected with 1.25 mg (0...
  31. Capsoni S, Giannotta S, Cattaneo A. Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice. Proc Natl Acad Sci U S A. 2002;99:12432-7 pubmed
    Phenotypic knockout of nerve growth factor (NGF) activity in transgenic anti-NGF mice (AD11 mice) results in a progressive neurodegenerative phenotype resembling Alzheimer's disease...
  32. Einarsdottir E, Carlsson A, Minde J, Toolanen G, Svensson O, Solders G, et al. A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception. Hum Mol Genet. 2004;13:799-805 pubmed
    ..genes in the disease critical region revealed a mutation in the coding region of the nerve growth-factor beta (NGFB) gene specific for the disease haplotype...
  33. Shalom D, Pillalamarri N, Xue X, Kohn N, Lind L, Winkler H, et al. Sacral nerve stimulation reduces elevated urinary nerve growth factor levels in women with symptomatic detrusor overactivity. Am J Obstet Gynecol. 2014;211:561.e1-5 pubmed publisher
    ..These findings support a larger study to validate the use of uNGF as an objective tool to assess therapeutic outcome in patients undergoing PNE for sacral neuromodulation. ..
  34. Lam D. Emerging factors in the progression of cancer-related pain. Pain Manag. 2016;6:487-96 pubmed publisher
    ..various peripheral mediators, including ATP, formaldehyde, protons, proteases, endothelin, bradykinin, TNF and NGF, that result in the activation and/or sensitization of peripheral and central neurons, that contribute to the ..
  35. Yamakita S, Matsuda M, Yamaguchi Y, Sawa T, Amaya F. Dexmedetomidine prolongs levobupivacaine analgesia via inhibition of inflammation and p38 MAPK phosphorylation in rat dorsal root ganglion. Neuroscience. 2017;361:58-68 pubmed publisher
    ..Macrophage accumulation, NGF, and TNF-? in the DRG and plantar tissue were measured using immunohistochemistry, real-time PCR and ELISA...
  36. Duarte J, Nascimento R, Martins P, d Avila Reis D. Evaluation of the immunoreactivity of nerve growth factor and tropomyosin receptor kinase A in the esophagus of noninfected and infected individuals with Trypanosoma cruzi. Parasitol Res. 2018;117:1647-1655 pubmed publisher
    ..In this study, we evaluated the immunoreactivity of nerve growth factor (NGF), and of its receptor tropomyosin receptor kinase A (TrkA), molecules that are well known for having a relevant ..
  37. Marte A, Messa M, Benfenati F, Onofri F. Synapsins Are Downstream Players of the BDNF-Mediated Axonal Growth. Mol Neurobiol. 2017;54:484-494 pubmed publisher
    ..neurons from Syn I knockout (KO) and Syn I/II/III KO mice, we studied the effects of BDNF and nerve growth factor (NGF) on axonal growth...
  38. Jensch A, Thomaseth C, Radde N. Sampling-based Bayesian approaches reveal the importance of quasi-bistable behavior in cellular decision processes on the example of the MAPK signaling pathway in PC-12 cell lines. BMC Syst Biol. 2017;11:11 pubmed publisher
    ..profile, which shows a transient response upon stimulation with EGF, while the response is sustained in case of NGF. This behavior was explained by different effective network topologies...
  39. Kitamoto T, Kitamoto A, Yoneda M, Hyogo H, Ochi H, Nakamura T, et al. Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan. Hum Genet. 2013;132:783-92 pubmed publisher
    ..Polymorphisms in the SAMM50 and PARVB genes in addition to those in the PNPLA3 gene were observed to be associated with the development and progression of NAFLD. ..
  40. Sabokbar A, Mahoney D, Hemingway F, Athanasou N. Non-Canonical (RANKL-Independent) Pathways of Osteoclast Differentiation and Their Role in Musculoskeletal Diseases. Clin Rev Allergy Immunol. 2016;51:16-26 pubmed publisher
    ..latter include transforming growth factor beta (TGF-β), interleukin-6 (IL-6), IL-8, IL-11, nerve growth factor (NGF), insulin-like growth factor-I (IGF-I) and IGF-II...
  41. Kwon J, Jo H, Park S, Ku C, Park D. Engraftment and regenerative effects of bone marrow stromal cell transplantation on damaged rat olfactory mucosa. Eur Arch Otorhinolaryngol. 2016;273:2585-90 pubmed publisher
    ..S100 immunohistochemical staining was used to measure nerve sheath regeneration. The increase in NGF (nerve growth factor) level in the olfactory mucosa was measured by Western blot analysis...
  42. Wang Z, Mong M, Yang Y, Yin M. Asiatic acid and maslinic acid attenuated kainic acid-induced seizure through decreasing hippocampal inflammatory and oxidative stress. Epilepsy Res. 2018;139:28-34 pubmed publisher
    ..at 10 and 20μM increased viability and decreased plasma membrane damage in KA treated nerve growth factor (NGF)-differentiated PC12 cells...
  43. Nassenstein C, Braun A, Erpenbeck V, Lommatzsch M, Schmidt S, Krug N, et al. The neurotrophins nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 are survival and activation factors for eosinophils in patients with allergic bronchial asthma. J Exp Med. 2003;198:455-67 pubmed
    Neurotrophins (nerve growth factor [NGF], brain-derived neurotrophic factor [BDNF], neurotrophin [NT]-3, and NT-4) have been observed in elevated concentrations in allergic diseases...
  44. Rupcic Z, Rascher M, Kanaki S, Köster R, Stadler M, Wittstein K. Two New Cyathane Diterpenoids from Mycelial Cultures of the Medicinal Mushroom Hericium erinaceus and the Rare Species, Hericium flagellum. Int J Mol Sci. 2018;19: pubmed publisher
    ..been attributed to the discovery of various terpenoids that can stimulate the production of nerve growth factor (NGF) or (as established more recently) brain-derived neurotrophic factor (BDNF) in cell-based bioassays...
  45. Sepúlveda Martínez A, Garrido M, Caamaño E, Vega M, Romero C, Parra Cordero M. Maternal Plasma Nerve Growth Factor at the 11+0-13+6 Weeks' Scan as a Potential Angiogenic Marker of Preeclampsia: A Pilot Study. Fetal Diagn Ther. 2017;41:202-208 pubmed publisher
    The aim of this study was to determine the role of nerve growth factor (NGF) in the first-trimester screening for preeclampsia (PE). Uterine artery Doppler (UtAD) was determined transvaginally...
  46. Zhang H, Wang K, Xing Y, Yu Q. Lysine-doped polypyrrole/spider silk protein/poly(l-lactic) acid containing nerve growth factor composite fibers for neural application. Mater Sci Eng C Mater Biol Appl. 2015;56:564-73 pubmed publisher
    ..Lysine-doped polypyrrole (PPy)/regenerated spider silk protein (RSSP)/poly(l-lactic) acid (PLLA)/nerve growth factor (NGF) (L-PRPN) composite scaffold was fabricated by co-axial electrospraying and electrospinning...
  47. Portes A, Giestal de Araujo E, Fagundes A, Pandolfo P, de Sá Geraldo A, Lira M, et al. Leishmania amazonensis infection induces behavioral alterations and modulates cytokine and neurotrophin production in the murine cerebral cortex. J Neuroimmunol. 2016;301:65-73 pubmed publisher
    ..4months post-infection, infected mice showed a decrease in IFN-γ, IL-1, IL-6, IL-4, IL-10 cytokines and BDNF and NGF neurotrophins in prefrontal cortex associated with increased anxiety behavior...
  48. Ribases M, Hervas A, Ramos Quiroga J, Bosch R, Bielsa A, Gastaminza X, et al. Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder. Biol Psychiatry. 2008;63:935-45 pubmed publisher
    ..subjects with 183 single nucleotide polymorphisms covering 10 candidate genes that encode four neurotrophins (NGF, BDNF, NTF3, and NTF4/5), a member of the cytokine family of NTFs (CNTF), and their receptors (NTRK1, NTRK2, NTRK3, ..
  49. Raychaudhuri S, Jiang W, Raychaudhuri S. Revisiting the Koebner phenomenon: role of NGF and its receptor system in the pathogenesis of psoriasis. Am J Pathol. 2008;172:961-71 pubmed publisher
    Nerve growth factor (NGF) influences the key pathological events of psoriasis: keratinocyte proliferation, angiogenesis, and T-cell activation...
  50. Shaker O, el Komy M, Tawfic S, Zeidán N, Tomairek R. Possible role of nerve growth factor and interleukin-18 in pathogenesis of eczematous lesions of atopic dermatitis. J Dermatol Sci. 2009;53:153-4 pubmed publisher
  51. Xu L, Li Y, Shi X, Han C, Tao L, Yang Q, et al. Expression, purification, and characterization of recombinant mouse nerve growth factor in Chinese hamster ovary cells. Protein Expr Purif. 2014;104:41-9 pubmed publisher
    Mouse NGF (mNGF) extracted from mouse submaxillary gland has been approved on the market in China for treating nerve damage caused by N-hexane poisoning for over a decade, and many researches showed the clinical effectiveness of mNGF for ..
  52. Duan J, Marcellus K, Qin X, Wang Y, Paudel H. Cystatin C promotes tau protein phosphorylation and causes microtubule instability by inhibiting intracellular turnover of GSK3β in neurons. Mol Cell Neurosci. 2018;89:1-8 pubmed publisher
    ..We demonstrate that CysC does not affect cellular Aβ production. However, when overexpressed in neuron (NGF-differentiated PC12 cells), CysC inhibits turnover of GSK3β, promotes GSK3β-catalyzed tau phosphorylation at Ser<..
  53. Mili B, Das K, Kumar A, Saxena A, Singh P, Ghosh S, et al. Preparation of NGF encapsulated chitosan nanoparticles and its evaluation on neuronal differentiation potentiality of canine mesenchymal stem cells. J Mater Sci Mater Med. 2017;29:4 pubmed publisher
    ..The present study aims to prepare the nerve growth factor (NGF) encapsulated chitosan nanoparticles (NGF-CNPs) and its evaluation on neuronal differentiation potentiality of ..
  54. Cui D, Zhang H, Yang B, Listman J, Li D, Price L, et al. Variation in NGFB is associated with primary affective disorders in women. Am J Med Genet B Neuropsychiatr Genet. 2011;156B:401-12 pubmed publisher
    ..b>NGFB, which encodes nerve growth factor ? and was represented in the array by 15 SNPs, showed the strongest evidence of ..
  55. Stabile A, Pistilli A, Crispoltoni L, Montagnoli C, Tiribuzi R, Casali L, et al. A role for NGF and its receptors TrKA and p75NTR in the progression of COPD. Biol Chem. 2016;397:157-63 pubmed publisher
    ..Our data demonstrate the involvement and modulation of nerve growth factor and its receptors in chronic obstructive pulmonary disease and in its staging. ..
  56. Leugers C, Lee G. Tau potentiates nerve growth factor-induced mitogen-activated protein kinase signaling and neurite initiation without a requirement for microtubule binding. J Biol Chem. 2010;285:19125-34 pubmed publisher
    ..we demonstrate that Tau potentiates AP-1 transcription factor activation in response to nerve growth factor (NGF)...
  57. Yoon J, Choi S, Lee J, Lee S, Lee S. Ocular surface inflammation, and nerve growth factor level in tears in active thyroid-associated ophthalmopathy. Graefes Arch Clin Exp Ophthalmol. 2010;248:271-6 pubmed publisher
    To measure tear nerve growth factor (NGF) concentrations in cases of active thyroid-associated ophthalmopathy (TAO) before and after glucocorticoid treatment, and to correlate NGF levels with disease inflammatory activity and thyroid ..
  58. Chan C, Liu X, Jang S, Hsu S, Williams I, Kang S, et al. NGF inhibits human leukemia proliferation by downregulating cyclin A1 expression through promoting acinus/CtBP2 association. Oncogene. 2009;28:3825-36 pubmed publisher
    ..Here we show that transcription corepressor CtBP2 directly binds acinus, which is regulated by nerve growth factor (NGF), inhibiting its stimulatory effect on cyclin A1, but not cyclin A2, expression in leukemia...
  59. Gentry J, Rutkoski N, Burke T, Carter B. A functional interaction between the p75 neurotrophin receptor interacting factors, TRAF6 and NRIF. J Biol Chem. 2004;279:16646-56 pubmed
    ..These results suggest that NRIF and TRAF6 functionally interact to facilitate neurotrophin signaling through the p75 receptor. ..
  60. Yamaguchi J, Aihara M, Kobayashi Y, Kambara T, Ikezawa Z. Quantitative analysis of nerve growth factor (NGF) in the atopic dermatitis and psoriasis horny layer and effect of treatment on NGF in atopic dermatitis. J Dermatol Sci. 2009;53:48-54 pubmed publisher
    The expression of nerve growth factor (NGF) is known to increase in the skin of patients with atopic dermatitis (AD) and is related to disease aggravation...
  61. Wang R, Yan F, Liao R, Wan P, Little P, Zheng W. Role of brain-derived neurotrophic factor and nerve growth factor in the regulation of Neuropeptide W in vitro and in vivo. Mol Cell Endocrinol. 2017;447:71-78 pubmed publisher
    Nerve growth factor (NGF) and Brain-derived neurotrophic factor (BDNF) are neurotrophic factors involved in the growth, survival and functioning of neurons...
  62. Naderi A, Teschendorff A, Beigel J, Cariati M, Ellis I, Brenton J, et al. BEX2 is overexpressed in a subset of primary breast cancers and mediates nerve growth factor/nuclear factor-kappaB inhibition of apoptosis in breast cancer cell lines. Cancer Res. 2007;67:6725-36 pubmed
    ..Both BEX1 and NGFRAP1 interact with p75NTR and modulate nerve growth factor (NGF) signaling through nuclear factor-kappaB (NF-kappaB) to regulate cell cycle, apoptosis, and differentiation in ..
  63. Gunay G, Sever M, Tekinay A, Guler M. Three-Dimensional Laminin Mimetic Peptide Nanofiber Gels for In Vitro Neural Differentiation. Biotechnol J. 2017;12: pubmed publisher
    ..induction of neural differentiation, even in the absence of a crucial biological inducer in nerve growth factor (NGF)...
  64. Mukai J, Shoji S, Kimura M, Okubo S, Sano H, Suvanto P, et al. Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis. J Biol Chem. 2002;277:13973-82 pubmed
    Nerve growth factor (NGF) can induce apoptosis in neural cells via activation of the low affinity neurotrophin receptor p75NTR...
  65. Aoki Y, Nakajima A, Ohtori S, Takahashi H, Watanabe F, Sonobe M, et al. Increase of nerve growth factor levels in the human herniated intervertebral disc: can annular rupture trigger discogenic back pain?. Arthritis Res Ther. 2014;16:R159 pubmed publisher
    Nerve growth factor (NGF) has an important role in the generation of discogenic pain. We hypothesized that annular rupture is a trigger for discogenic pain through the action of NGF...
  66. Feng L, Xie X, Ding Q, Luo X, He J, Fan F, et al. Spatial regulation of Raf kinase signaling by RKTG. Proc Natl Acad Sci U S A. 2007;104:14348-53 pubmed
    ..RKTG expression inhibits EGF-stimulated ERK and RSK phosphorylation, blocks NGF-mediated PC12 cell differentiation, and antagonizes Ras- and Raf-1-stimulated Elk-1 transactivation...
  67. Amoras E, Gomes S, Freitas F, Santana B, Ishak G, de Araújo M, et al. NGF and P75NTR gene expression is associated with the hepatic fibrosis stage due to viral and non-viral causes. PLoS ONE. 2015;10:e0121754 pubmed publisher
    This study evaluated the relative mRNA expression levels of nerve growth factor (NGF) and the p75 neurothrophin receptor (p75NTR) in different histological stages of human liver disease...
  68. Takai S, Majima T, Reinhart B, Goins W, Funahashi Y, Gotoh M, et al. Effects of herpes simplex virus vectors encoding poreless TRPV1 or protein phosphatase 1? in a rat cystitis model induced by hydrogen peroxide. Gene Ther. 2017;: pubmed publisher
    ..Also, both treatments reduced NGF expression in the bladder mucosa, reduced bladder inflammation characterized by infiltration of inflammatory cells, ..
  69. Zhang X, Wang X, Zhang J, Pan X, Jiang J, Li Y. Effects of Taurine on Alterations of Neurobehavior and Neurodevelopment Key Proteins Expression in Infant Rats by Exposure to Hexabromocyclododecane. Adv Exp Med Biol. 2017;975 Pt 1:119-130 pubmed publisher
    ..The protein expressions of brain derived neurotrophic factor (BDNF), nerve growth factor (NGF) and fibroblast growth factor (FGF) were assayed by Western-blotting...
  70. Bhakta A, Gavini K, Yang E, Lyman Henley L, Parameshwaran K. Chronic traumatic stress impairs memory in mice: Potential roles of acetylcholine, neuroinflammation and corticotropin releasing factor expression in the hippocampus. Behav Brain Res. 2017;335:32-40 pubmed publisher
    ..There were no changes in brain derived neurotrophic factor (BDNF) or nerve growth factor (NGF) levels in the hippocampus of stressed mice...
  71. Chen S, Jiang Y, Kuo H. Urinary biomarkers in patients with detrusor underactivity with and without bladder function recovery. Int Urol Nephrol. 2017;49:1763-1770 pubmed publisher
    ..Urine collection at baseline was performed, and the urinary protein including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and prostaglandin E2 (PGE2) were measured by ELISA...
  72. Ruggeri P, Cappabianca L, Farina A, Gneo L, MacKay A. NGF FLIPs TrkA onto the death TRAIL in neuroblastoma cells. Cell Death Dis. 2016;7:e2139 pubmed publisher
  73. Li C, Zheng L, Wang C, Zhou X. Absence of nerve growth factor and comparison of tyrosine kinase receptor A levels in mature spermatozoa from oligoasthenozoospermic, asthenozoospermic and fertile men. Clin Chim Acta. 2010;411:1482-6 pubmed publisher
    Nerve growth factor (NGF) and the Tyrosine kinase receptor (TrkA) are expressed in mammalian ovaries and testes, where they are involved in oocyte maturation and spermatogenesis...