Gene Symbol: NFKBIL1
Description: NFKB inhibitor like 1
Alias: IKBL, LST1, NFKBIL, NF-kappa-B inhibitor-like protein 1, I-kappa-B-like protein, ikappaBL, inhibitor of kappa B-like protein, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
Species: human
Products:     NFKBIL1

Top Publications

  1. de la Concha E, Fernandez Arquero M, Lopez Nava G, Martin E, Allcock R, Conejero L, et al. Susceptibility to severe ulcerative colitis is associated with polymorphism in the central MHC gene IKBL. Gastroenterology. 2000;119:1491-5 pubmed
    b>IKBL gene lies telomeric of the tumor necrosis factor cluster in the central major histocompatibility complex and carries a structural polymorphism at position +738...
  2. Shichi D, Kikkawa E, Ota M, Katsuyama Y, Kimura A, Matsumori A, et al. The haplotype block, NFKBIL1-ATP6V1G2-BAT1-MICB-MICA, within the class III-class I boundary region of the human major histocompatibility complex may control susceptibility to hepatitis C virus-associated dilated cardiomyopathy. Tissue Antigens. 2005;66:200-8 pubmed
    ..We mapped HCV-DCM susceptibility to a non-HLA gene locus spanning from NFKBIL1 to MICA gene loci within the MHC class III-class I boundary region...
  3. Owecki M, Kowal P, Kaczmarek Ryśs M, Hoppe Gołebiewska J, Nikisch E, Tokarz Kupczyk E, et al. [Association study between exon 4 NFKBIL1 polymorphism and multiple sclerosis]. Pol Merkur Lekarski. 2010;28:366-70 pubmed
    ..3). NFKBIL1 gene (locus 6p21.31) is one of candidate genes...
  4. Albertella M, Campbell R. Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins. Hum Mol Genet. 1994;3:793-9 pubmed
    ..It contains one partial and two full ANK repeats, which bear a marked similarity to those in the I kappa B family of proteins, suggesting that the protein encoded by the novel gene could represent a divergent member of this family. ..
  5. Lin C, Cho C, Tsai W, Ou T, Wu C, Yen J, et al. Inhibitors of kB-like gene polymorphisms in rheumatoid arthritis. Immunol Lett. 2006;105:193-7 pubmed
    To investigate the role of inhibitor of kB-like (IkBL) gene polymorphisms in the pathogenesis of rheumatoid arthritis (RA) in Taiwan. One hundred and twenty-nine patients with RA and 110 healthy controls were enrolled in this study...
  6. Allcock R, Christiansen F, Price P. The central MHC gene IKBL carries a structural polymorphism that is associated with HLA-A3,B7,DR15. Immunogenetics. 1999;49:660-5 pubmed
    ..Here we address the IKBL gene, which lies near the TNF cluster at the telomeric end of the central MHC...
  7. Okamoto K, Makino S, Yoshikawa Y, Takaki A, Nagatsuka Y, Ota M, et al. Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis. Am J Hum Genet. 2003;72:303-12 pubmed
    ..Therefore, the MHC may harbor RA genetic determinants affecting the innate and adaptive arms of the immune system. ..
  8. Weidle U, Rohwedder I, Birzele F, Weiss E, Schiller C. LST1: A multifunctional gene encoded in the MHC class III region. Immunobiology. 2018;: pubmed publisher
    The LST1 gene is located in the MHC class III cluster between the MHC class I and II regions...
  9. Nikamo P, Lysell J, Ståhle M. Association with Genetic Variants in the IL-23 and NF-κB Pathways Discriminates between Mild and Severe Psoriasis Skin Disease. J Invest Dermatol. 2015;135:1969-1976 pubmed publisher
    ..onset and gender, revealed significant differences between the two groups for SNPs in IL23R, NFKB1, IL21, IL12B, NFKBIL1 and IL23A. HLA-C*06 associated equally in the mild and severe disease cohorts...

More Information


  1. Leist S, Kollmus H, Hatesuer B, Lambertz R, Schughart K. Lst1 deficiency has a minor impact on course and outcome of the host response to influenza A H1N1 infections in mice. Virol J. 2016;13:17 pubmed publisher
    ..We found Lst1 (leukocyte specific transcript 1) as one of the most promising candidate genes in the Qivr17-2 locus because it is ..
  2. Fritsch Stork R, Silva Cardoso S, Groot Koerkamp M, Broen J, Lafeber F, Bijlsma J. Expression of ERAP2 and LST1 is increased before start of therapy in rheumatoid arthritis patients with good clinical response to glucocorticoids. Clin Exp Rheumatol. 2016;34:685-9 pubmed
    ..increased in CD4+T-cells of GC-responders; expression of ERAP2 (endoplasmic reticulum aminopeptidase 2), LST1 (leucocyte-specific transcript 1) and FAM26F (Family With Sequence Similarity 26, Member F) was confirmed by ..
  3. Chen Y, Shen C, Guha D, Ding M, Kulich S, Ashimkhanova A, et al. Identification of the transcripts associated with spontaneous HCV clearance in individuals co-infected with HIV and HCV. BMC Infect Dis. 2016;16:693 pubmed
    ..Importantly, a number of these 12 genes and their upstream regulators (such as CCL3, IL17D, LBP, SOCS3, NFKBIL1, IRF) are associated with innate immune response functions...
  4. Yang W, Chen X, Zhao H, Niu C, Zhang B, Xu Y, et al. Postmortem Study of Validation of Low Signal on Fat-Suppressed T1-Weighted Magnetic Resonance Imaging as Marker of Lipid Core in Middle Cerebral Artery Atherosclerosis. Stroke. 2016;47:2299-304 pubmed publisher
    ..However, the underlying plaque component of low signal on T1-weighted fat-suppressed images (LST1) has never been explored...
  5. Shibata H, Yasunami M, Obuchi N, Takahashi M, Kobayashi Y, Numano F, et al. Direct determination of single nucleotide polymorphism haplotype of NFKBIL1 promoter polymorphism by DNA conformation analysis and its application to association study of chronic inflammatory diseases. Hum Immunol. 2006;67:363-73 pubmed
    ..susceptibility genes for Takayasu's arteritis (TA) was mapped between TNFA and MICB loci and that -63T allele of NFKBIL1, which is between TNFA and MICB loci, was associated with rheumatoid arthritis (RA) in the Japanese population...
  6. Iris F, Bougueleret L, Prieur S, Caterina D, Primas G, Perrot V, et al. Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment. Nat Genet. 1993;3:137-45 pubmed
    ..The most telomeric 3.8 kb contains three potential exons, one of which bears strong homology to the ankyrin domain of the DNA binding factors NF kappa B and I kappa B. ..
  7. An J, Nakajima T, Shibata H, Arimura T, Yasunami M, Kimura A. A novel link of HLA locus to the regulation of immunity and infection: NFKBIL1 regulates alternative splicing of human immune-related genes and influenza virus M gene. J Autoimmun. 2013;47:25-33 pubmed publisher
    ..Inhibitor of ?B-like protein (I?BL), encoded by HLA-linked NFKBIL1, is a protein of unknown function, while genetic variations in NFKBIL1 are known to associate with the ..
  8. Oliveira L, Porta G, Marin M, Bittencourt P, Kalil J, Goldberg A. Autoimmune hepatitis, HLA and extended haplotypes. Autoimmun Rev. 2011;10:189-93 pubmed publisher
    ..genotyped 107 AIH-1 children and up to 326 healthy subjects for TNFA G-308A, TNFA G-238A, LTA A+252G, LTA A+80C, NFKBIL1 T-63A, BAT1 C-348T, BAT1 G-22C, MICA, and HLA-B polymorphisms...
  9. Tan J, Price P, Gut I, Stacey M, Warrington N, Wallace H. Characterization of tumor necrosis factor-? block haplotypes associated with susceptibility to chronic venous leg ulcers in Caucasian patients. Hum Immunol. 2010;71:1214-9 pubmed publisher
    ..FV16 appears to be the best MHC and TNF block marker of susceptibility. After disease onset, an individual's TNF block haplotype does not modulate CVLU severity. ..
  10. Greetham D, Ellis C, Mewar D, Fearon U, an Ultaigh S, Veale D, et al. Functional characterization of NF-kappaB inhibitor-like protein 1 (NFkappaBIL1), a candidate susceptibility gene for rheumatoid arthritis. Hum Mol Genet. 2007;16:3027-36 pubmed
    Several studies have implicated the NF-kappaB inhibitor-like protein 1 (NFkBIL1) gene located in the class III region of the major histocompatibility complex (MHC) as a possible susceptibility locus for rheumatoid arthritis (RA)...
  11. Glas J, Török H, Tonenchi L, Muller Myhsok B, Mussack T, Wetzke M, et al. Role of the NFKB1 -94ins/delATTG promoter polymorphism in IBD and potential interactions with polymorphisms in the CARD15/NOD2, IKBL, and IL-1RN genes. Inflamm Bowel Dis. 2006;12:606-11 pubmed
    ..Furthermore, potential interactions of the -94ins/delATTG polymorphism with the IKBL and the IL-1RN genes should be determined...
  12. Koch W, Hoppmann P, Michou E, Jung V, Pfeufer A, Müller J, et al. TaqMan assays for genotyping of single nucleotide polymorphisms present at a disease susceptibility locus on chromosome 6. Clin Chem Lab Med. 2005;43:167-72 pubmed
    Multiple single-nucleotide polymorphisms in the BAT1-NFKBIL1-LTA region on the short arm of chromosome 6 have been found to be associated with susceptibility to myocardial infarction in a recent case-control study including individuals ..
  13. Ota M, Katsuyama Y, Hamano H, Umemura T, Kimura A, Yoshizawa K, et al. Two critical genes (HLA-DRB1 and ABCF1)in the HLA region are associated with the susceptibility to autoimmune pancreatitis. Immunogenetics. 2007;59:45-52 pubmed
    ..that of single nucleotide polymorphism within the 5'-flanking regions of the TNFA and IkBLI (also known as NFKBIL1) as well as HLA class I and II genes...
  14. Shiina T, Tamiya G, Oka A, Yamagata T, Yamagata N, Kikkawa E, et al. Nucleotide sequencing analysis of the 146-kilobase segment around the IkBL and MICA genes at the centromeric end of the HLA class I region. Genomics. 1998;47:372-82 pubmed
    ..human major histocompatibility complex on chromosome 6, a YAC clone (745D12) covering the 146-kb segment around the IkBL and MICA loci was isolated from a YAC library constructed from the B-cell line, BOLETH...
  15. D Aloia A, Berruti G, Costa B, Schiller C, Ambrosini R, Pastori V, et al. RalGPS2 is involved in tunneling nanotubes formation in 5637 bladder cancer cells. Exp Cell Res. 2018;362:349-361 pubmed publisher
    ..we found that RalGPS2 interacts with the transmembrane MHC class III protein leukocyte specific transcript 1 (LST1) and RalA, leading to the formation of a complex which promotes TNTs generation...
  16. Neville M, Campbell R. A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC. J Immunol. 1999;162:4745-54 pubmed
    ..inflammatory factor 1, G1, 1C7, leukocyte-specific transcript 1 (B144), lymphotoxin B, TNF, lymphotoxin A, NB6, IKBL, BAT1 (centromere to telomere), and their genomic structures have been defined...
  17. Gichohi Wainaina W, Melse Boonstra A, Swinkels D, Zimmermann M, Feskens E, Towers G. Common Variants and Haplotypes in the TF, TNF-α, and TMPRSS6 Genes Are Associated with Iron Status in a Female Black South African Population. J Nutr. 2015;145:945-53 pubmed publisher
    ..both in tumor necrosis factor-α (TNF-α) and rs2071592 in nuclear factor κB inhibitor-like protein 1 (NFKBIL1) was associated with higher odds for low SF concentrations (SF < 15 μg/L; OR: 1.86; 95% CI: 1.23, 2...
  18. Yamashita T, Hamaguchi K, Kusuda Y, Kimura A, Sakata T, Yoshimatsu H. IKBL promoter polymorphism is strongly associated with resistance to type 1 diabetes in Japanese. Tissue Antigens. 2004;63:223-30 pubmed
    ..We investigated the possibility of the inhibitor of kappaB-like (IKBL, also known as 'NFKBIL1') gene as one of these candidates...
  19. Chinoy H, Li C, Platt H, Fertig N, Varsani H, Gunawardena H, et al. Genetic association study of NF-κB genes in UK Caucasian adult and juvenile onset idiopathic inflammatory myopathy. Rheumatology (Oxford). 2012;51:794-9 pubmed publisher
    ..A significant allele association was observed in the overall IIM group vs controls for the IKBL-62T allele (rs2071592, odds ratio 1.5, 95% CI 1.21, 1.89, corrected P = 0...
  20. Cordeiro Q, Cappi C, Sampaio A, Palácios S, Pereira C, Shavitt R, et al. Association study between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder. Rev Bras Psiquiatr. 2009;31:131-5 pubmed
    ..The nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 (NFKBIL1) has been suggested as a modulator of the immunological system...
  21. Gomez L, Camargo J, Castiblanco J, Ruiz Narvaez E, Cadena J, Anaya J. Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis. Tissue Antigens. 2006;67:290-6 pubmed
    ..Interleukin-1 beta (IL-1beta) and the inhibitor of kB-like (IkBL) are important molecules that participate in the inflammatory response required for the immunological control of a ..
  22. Ryan A, O Brien E, Shields D, McManus R. Lack of association between NFKBIL1/LTA polymorphisms and hypertension, myocardial infarct, unstable angina and stable angina in a large Irish population sample. Atherosclerosis. 2008;197:465-6 pubmed
  23. Valdes A, Thomson G. Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1. Diabetes Obes Metab. 2009;11 Suppl 1:46-52 pubmed publisher
    ..Our data confirm that the class III region is involved in T1D susceptibility and suggest that more than one gene in the region is involved. ..
  24. Koch W, Hoppmann P, Michou E, Jung V, Pfeufer A, Mueller J, et al. Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans. Hum Mol Genet. 2007;16:1821-7 pubmed
    Single-nucleotide polymorphisms within the BAT1-NFKBIL1-LTA genomic region (6p21.3) and the LGALS2 gene (22q13...
  25. Eike M, Olsson M, Undlien D, Dahl Jørgensen K, Joner G, Rønningen K, et al. Genetic variants of the HLA-A, HLA-B and AIF1 loci show independent associations with type 1 diabetes in Norwegian families. Genes Immun. 2009;10:141-50 pubmed publisher
    ..Our results illustrate the importance of a comprehensive adjustment for LD effects when performing association studies in this complex. ..
  26. Miterski B, Drynda S, Böschow G, Klein W, Oppermann J, Kekow J, et al. Complex genetic predisposition in adult and juvenile rheumatoid arthritis. BMC Genet. 2004;5:2 pubmed
    ..genotyped for HLA-DRB1, TNFa, TNFA -238a/g, TNFA -308a/g, TNFA -857c/t, TNFR1 -609g/t, TNFR1 P12P, TNFR2 del 15bp, IKBL -332a/g, IKBL -132t/a, IKBL C224R, CTLA4 -318c/t, CTLA4 T17A, PTPRC P57P, MIF -173g/c, the MIF and IFNG ..
  27. Prasad S, Bhatia T, Kukshal P, Nimgaonkar V, Deshpande S, Thelma B. Attempts to replicate genetic associations with schizophrenia in a cohort from north India. NPJ Schizophr. 2017;3:28 pubmed publisher
    ..07); rs3130615, MICB (p?=?0.08); rs6916921, NFKBIL1 (p?=?0.08) and rs9273012, HLA-DQA1 (p?=?0.06) and haplotypic associations (p?=?0.01-0...
  28. Ramasawmy R, Fae K, Cunha Neto E, Borba S, Ianni B, Mady C, et al. Variants in the promoter region of IKBL/NFKBIL1 gene may mark susceptibility to the development of chronic Chagas' cardiomyopathy among Trypanosoma cruzi-infected individuals. Mol Immunol. 2008;45:283-8 pubmed
    ..The human inhibitory kappaB-like gene (IKBL/NFKBIL1), homologous to the IkappaB family of proteins that regulate the NFkappaB family of transcription factors, is ..
  29. Sato H, Grutters J, Pantelidis P, Mizzon A, Ahmad T, van Houte A, et al. HLA-DQB1*0201: a marker for good prognosis in British and Dutch patients with sarcoidosis. Am J Respir Cell Mol Biol. 2002;27:406-12 pubmed
  30. Martinez A, Pascual M, Pascual Salcedo D, Balsa A, Martin J, de la Concha E. Genetic polymorphisms in Spanish rheumatoid arthritis patients: an association and linkage study. Genes Immun. 2003;4:117-21 pubmed
    ..IL-6 -622 promoter SNP, FcgammaRIIIA Val/Phe-158 polymorphism, IL-1 receptor antagonist VNTR, and the IKBL+738 T/C mutation. The analysis has been performed on a case-control study and also on RA trios...
  31. Kariz S, Milutinovic A, Bregar D, Terzic I, Terzić R, Lovrecic L, et al. The interleukin-1 receptor antagonist gene and the inhibitor of kappa B-like protein gene polymorphisms are not associated with myocardial infarction in Slovene population with type 2 diabetes. Coll Antropol. 2007;31:503-7 pubmed
    ..gene variable number tandem repeat (IL1RN VNTR) polymorphism and of the inhibitor of kappa B-like protein (IKBL) gene polymorphism with myocardial infarction (MI) in a group of patients with type 2 diabetes...
  32. Watanabe Y, Nunokawa A, Kaneko N, Muratake T, Arinami T, Ujike H, et al. Two-stage case-control association study of polymorphisms in rheumatoid arthritis susceptibility genes with schizophrenia. J Hum Genet. 2009;54:62-5 pubmed publisher
    ..Recently, extensive studies have identified some RA susceptibility genes, including NFKBIL1, SLC22A4, RUNX1, FCRL3 and PADI4, in the Japanese population...
  33. Castiblanco J, Anaya J. The IkappaBL gene polymorphism influences risk of acquiring systemic lupus erythematosus and Sjögren's syndrome. Hum Immunol. 2008;69:45-51 pubmed publisher
    The human inhibitory kappaB-like gene (IkappaBL) maps to a chromosomal region approximately 25 kb telomeric of the TNF gene at 6p21.3...
  34. Migita O, Noguchi E, Koga M, Jian Z, Shibasaki M, Migita T, et al. Haplotype analysis of a 100 kb region spanning TNF-LTA identifies a polymorphism in the LTA promoter region that is associated with atopic asthma susceptibility in Japan. Clin Exp Allergy. 2005;35:790-6 pubmed
    ..We screened for mutations in the coding and promoter regions of genes in the TNF-LTA region, including BAT1, NFKBIL1, LTA, TNF, LTB, AIF, and BAT2, and conducted a transmission disequilibrium test of 41 polymorphisms in 137 ..
  35. Atzei P, Gargan S, Curran N, Moynagh P. Cactin targets the MHC class III protein IkappaB-like (IkappaBL) and inhibits NF-kappaB and interferon-regulatory factor signaling pathways. J Biol Chem. 2010;285:36804-17 pubmed publisher
    ..This study thus defines hCactin as a novel negative regulator of TLR signaling and reveals its capacity to target MHC Class III genes at the molecular and functional level. ..
  36. Clancy R, Marion M, Kaufman K, Ramos P, Adler A, Harley J, et al. Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus. Arthritis Rheum. 2010;62:3415-24 pubmed publisher
    ..These results suggest that variation near genes related to inflammatory and apoptotic responses may promote cardiac injury initiated by passively acquired autoantibodies. ..
  37. Kurylowicz A, Miskiewicz P, Bar Andziak E, Nauman J, Bednarczuk T. Association of polymorphism in genes encoding kappaB inhibitors (IkappaB) with susceptibility to and phenotype of Graves' disease: a case-control study. Thyroid Res. 2009;2:10 pubmed publisher
    ..aim of this study was to investigate an association of polymorphisms in two genes encoding NF-kappaB inhibitors: IKBL (encoding inhibitor of kappaB-like) and NFKBIA (encoding kappaB inhibitor alpha), withsusceptibility to and ..
  38. Read R, Teare D, Pridmore A, Naylor S, Timms J, Kaczmarski E, et al. The tumor necrosis factor polymorphism TNF (-308) is associated with susceptibility to meningococcal sepsis, but not with lethality. Crit Care Med. 2009;37:1237-43 pubmed publisher
    ..genotyped at eight other markers in strong linkage disequilibrium with TNF (-308); these markers were IkappaBL (-62), BAT3, LST1, NOTCH4 (+1297), NOTCH4 (+3061), CCHCR1 (+436), CCHCR1 (+2271), and LTalpha...
  39. Kominami S, Tanabe N, Ota M, Naruse T, Katsuyama Y, Nakanishi N, et al. HLA-DPB1 and NFKBIL1 may confer the susceptibility to chronic thromboembolic pulmonary hypertension in the absence of deep vein thrombosis. J Hum Genet. 2009;54:108-14 pubmed publisher
    ..characteristics of patients stratified by the presence of susceptibility genes implied that the DPB1 gene controlled the severity of the vascular lesion, whereas the IKBL gene (NFKBIL1) was associated with a relatively mild phenotype.
  40. Yau A, Tuncel J, Haag S, Norin U, Houtman M, Padyukov L, et al. Conserved 33-kb haplotype in the MHC class III region regulates chronic arthritis. Proc Natl Acad Sci U S A. 2016;113:E3716-24 pubmed publisher
    ..haplotype consists of five polymorphic immunoregulatory genes: Lta (lymphotoxin-?), Tnf, Ltb (lymphotoxin-?), Lst1 (leukocyte-specific transcript 1), and Ncr3 (natural cytotoxicity-triggering receptor 3)...