Gene Symbol: NFKB2
Description: nuclear factor kappa B subunit 2
Alias: CVID10, H2TF1, LYT-10, LYT10, NF-kB2, p100, p49/p100, p52, nuclear factor NF-kappa-B p100 subunit, DNA-binding factor KBF2, NFKB, p52/p100 subunit, lymphocyte translocation chromosome 10 protein, nuclear factor Kappa-B, subunit 2, nuclear factor NF-kappa-B p52 subunit, nuclear factor of Kappa light chain gene enhancer in B cells 2, nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100), oncogene Lyt-10, transcription factor NFKB2
Species: human
Products:     NFKB2

Top Publications

  1. Neri A, Chang C, Lombardi L, Salina M, Corradini P, Maiolo A, et al. B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappa B p50. Cell. 1991;67:1075-87 pubmed
    ..The lyt-10 gene defines a new subfamily (rel/poly-G/ankyrin) of NF-kappa B-rel transcription factors with potential for oncogenic activation in human cancer. ..
  2. Conant K, Ma M, Nath A, Major E. Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes. J Virol. 1996;70:1384-9 pubmed
    ..These effects include Tat's ability to upregulate the synthesis of specific cytokines and to act as a growth factor. ..
  3. Baldwin A. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol. 1996;14:649-83 pubmed
  4. Xiao G, Harhaj E, Sun S. NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol Cell. 2001;7:401-9 pubmed
    Processing of the nf(kappa)b2 gene product p100 to generate p52 is an important step in NF-kappaB regulation...
  5. Sheng W, Hu S, Lokensgard J, Peterson P. U50,488 inhibits HIV-1 Tat-induced monocyte chemoattractant protein-1 (CCL2) production by human astrocytes. Biochem Pharmacol. 2003;65:9-14 pubmed
    ..These findings suggest that KOR ligands could have an anti-inflammatory effect in the CNS and thereby be beneficial in the treatment of HIV-1-associated brain disease. ..
  6. Derudder E, Laferté A, Ferreira V, Mishal Z, Baud V, Tarantino N, et al. Identification and characterization of p100HB, a new mutant form of p100/NF-kappa B2. Biochem Biophys Res Commun. 2003;308:744-9 pubmed
    b>P100, which is encoded by NF-kappa B2, inhibits Rel dimers. It can also be processed into p52, one of the DNA binding sub-units of NF-kappa B/Rel factors...
  7. Nadiminty N, Lou W, Lee S, Lin X, Trump D, Gao A. Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation. Proc Natl Acad Sci U S A. 2006;103:7264-9 pubmed
    Activation of the noncanonical NF-kappaB signaling pathway involved in the proteolytic processing of NF-kappaB p100 to p52 is tightly regulated, and overproduction of p52 leads to lymphocyte hyperplasia and transformation...
  8. Basak S, Kim H, Kearns J, Tergaonkar V, O Dea E, Werner S, et al. A fourth IkappaB protein within the NF-kappaB signaling module. Cell. 2007;128:369-81 pubmed
    ..We report here the characterization of a fourth inhibitor, nfkappab2/p100, that forms two distinct inhibitory complexes with RelA, one of which mediates developmental NF-kappaB activation...
  9. Migliazza A, Lombardi L, Rocchi M, Trecca D, Chang C, Antonacci R, et al. Heterogeneous chromosomal aberrations generate 3' truncations of the NFKB2/lyt-10 gene in lymphoid malignancies. Blood. 1994;84:3850-60 pubmed
    The NFKB2(lyt-10) gene codes for a protein that is a member of the NK-kappa B/rel family of transcription factors containing a DNA-binding rel domain and a carboxy-terminal ankyrin-like domain...

More Information

Publications180 found, 100 shown here

  1. Liptay S, Schmid R, Nabel E, Nabel G. Transcriptional regulation of NF-kappa B2: evidence for kappa B-mediated positive and negative autoregulation. Mol Cell Biol. 1994;14:7695-703 pubmed
    ..In contrast to other family members, we find that kappa B elements in the NFKB2 promoter can also mediate transcriptional repression in the absence of NF-kappa B...
  2. Thakur S, Lin H, Tseng W, Kumar S, Bravo R, Foss F, et al. Rearrangement and altered expression of the NFKB-2 gene in human cutaneous T-lymphoma cells. Oncogene. 1994;9:2335-44 pubmed
    ..DNA sequence predicted the presence of a truncated 80 kD NFKB-2 precursor protein (p80HT), instead of the normal p100 protein. No wild-type allele was identified...
  3. Chen F, Castranova V, Shi X, Demers L. New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases. Clin Chem. 1999;45:7-17 pubmed
    ..Therefore, development of modulatory strategies targeting this transcription factor may provide a novel therapeutic tool for the treatment or prevention of various diseases. ..
  4. Rocha S, Martin A, Meek D, Perkins N. p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1. Mol Cell Biol. 2003;23:4713-27 pubmed
    ..was dependent on the proximal NF-kappaB binding site of the cyclin D1 promoter, which has been shown to bind the p52 NF-kappaB subunit...
  5. Liang C, Zhang M, Sun S. beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870. Cell Signal. 2006;18:1309-17 pubmed
    Processing of the NF-kappaB2 precursor protein p100 is a major step in noncanonical NF-kappaB signaling. This signaling step requires the NF-kappaB inducing kinase (NIK) and its downstream kinase, IkappaB kinase alpha (IKKalpha)...
  6. Bernal Mizrachi L, Lovly C, Ratner L. The role of NF-{kappa}B-1 and NF-{kappa}B-2-mediated resistance to apoptosis in lymphomas. Proc Natl Acad Sci U S A. 2006;103:9220-5 pubmed
    ..These findings demonstrate an important role of both NF-kappaB pathways in mediating resistance to apoptosis and distinctive antiapoptotic downstream target gene profiles responsible for this effect. ..
  7. Schumm K, Rocha S, Caamano J, Perkins N. Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit. EMBO J. 2006;25:4820-32 pubmed
    The p52/p100 nuclear factor kappa B (NF-kappaB) subunit (NF-kappaB2) is aberrantly expressed in many tumour types and has been implicated as a regulator of cell proliferation...
  8. Vallabhapurapu S, Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol. 2009;27:693-733 pubmed publisher
    ..including RelA, c-Rel, RelB, NF-kappaB1 (p50 and its precursor p105), and NF-kappaB2 (p52 and its precursor p100), plays a central role in the immune system by regulating several processes ranging from the development and ..
  9. Busino L, Millman S, Scotto L, Kyratsous C, Basrur V, O CONNOR O, et al. Fbxw7?- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma. Nat Cell Biol. 2012;14:375-85 pubmed publisher
    ..Using differential purifications and mass spectrometry, we identified p100, an inhibitor of NF-?B signalling, as an interactor of Fbxw7?...
  10. Chen K, Coonrod E, Kumanovics A, Franks Z, Durtschi J, Margraf R, et al. Germline mutations in NFKB2 implicate the noncanonical NF-κB pathway in the pathogenesis of common variable immunodeficiency. Am J Hum Genet. 2013;93:812-24 pubmed publisher
    ..2564delA (p.Lys855Serfs(∗)7), in NFKB2 affecting the C terminus of NF-κB2 (also known as p100/p52 or p100/p49)...
  11. Fracchiolla N, Lombardi L, Salina M, Migliazza A, Baldini L, Berti E, et al. Structural alterations of the NF-kappa B transcription factor lyt-10 in lymphoid malignancies. Oncogene. 1993;8:2839-45 pubmed
    ..This gene, called lyt-10 (NFKB2/p52), is a member of the NF-kappa B family of transcription factors and displays a high degree of homology with ..
  12. Neri A, Fracchiolla N, Migliazza A, Trecca D, Lombardi L. The involvement of the candidate proto-oncogene NFKB2/lyt-10 in lymphoid malignancies. Leuk Lymphoma. 1996;23:43-8 pubmed
    ..Two subunits, NF-kappa B1p50 and NF-kappa B2p52, coded respectively by the NFKB1 and NFKB2 genes, may only have DNA binding activity...
  13. Kim K, Gu C, Thakur S, Vieira E, Lin J, Rabson A. Transcriptional regulatory effects of lymphoma-associated NFKB2/lyt10 protooncogenes. Oncogene. 2000;19:1334-45 pubmed
    C-terminal truncations of the NFKB2 p100 gene product have been observed in a number of cases of human cutaneous T cell lymphomas, as well as human B-cell lymphomas and myelomas...
  14. Wang Y, Cui H, Schroering A, Ding J, Lane W, McGill G, et al. NF-kappa B2 p100 is a pro-apoptotic protein with anti-oncogenic function. Nat Cell Biol. 2002;4:888-93 pubmed
    ..The only NF-kappa B family member known to be mutated in human cancer is NF-kappa B2 p100 (ref. 2), a factor with I kappa B activity...
  15. Qing G, Xiao G. Essential role of IkappaB kinase alpha in the constitutive processing of NF-kappaB2 p100. J Biol Chem. 2005;280:9765-8 pubmed
    Processing of NF-kappaB2 precursor protein p100 to generate p52 is tightly controlled, which is important for proper function of NF-kappaB...
  16. Qing G, Qu Z, Xiao G. Stabilization of basally translated NF-kappaB-inducing kinase (NIK) protein functions as a molecular switch of processing of NF-kappaB2 p100. J Biol Chem. 2005;280:40578-82 pubmed
    The non-canonical pathway based on processing of NF-kappaB2 precursor protein p100 to generate p52 plays a critical role in controlling B cell function and lymphoid organogenesis...
  17. de Wit H, Dokter W, Koopmans S, Lummen C, van der Leij M, Smit J, et al. Regulation of p100 (NFKB2) expression in human monocytes in response to inflammatory mediators and lymphokines. Leukemia. 1998;12:363-70 pubmed
    ..A p100 subunit of NF-kappaB has IkappaB-like properties by sequestering the p65 transactivating subunit in the cytosol of ..
  18. Lee C, Fulcher D, Whittle B, Chand R, Fewings N, Field M, et al. Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100. Blood. 2014;124:2964-72 pubmed publisher
    ..B-cell deficiency associated with partial persistence of serum immunoglobulin arising from a missense mutation in NFKB2. Significantly, this point mutation results in a D865G substitution and causes a failure of p100 phosphorylation ..
  19. Liu P, Li K, Garofalo R, Brasier A. Respiratory syncytial virus induces RelA release from cytoplasmic 100-kDa NF-kappa B2 complexes via a novel retinoic acid-inducible gene-I{middle dot}NF- kappa B-inducing kinase signaling pathway. J Biol Chem. 2008;283:23169-78 pubmed publisher
    ..In this study, we surprisingly found that RIG-I silencing also inhibited p100 processing to 52-kDa NF-kappaB2 ("p52"), suggesting that RIG-I was functionally upstream of the ..
  20. Dorman S, Baranova K, Knoll J, Urquhart B, Mariani G, Carcangiu M, et al. Genomic signatures for paclitaxel and gemcitabine resistance in breast cancer derived by machine learning. Mol Oncol. 2016;10:85-100 pubmed publisher
    ..Expression of 15 genes (ABCC10, BCL2, BCL2L1, BIRC5, BMF, FGF2, FN1, MAP4, MAPT, NFKB2, SLCO1B3, TLR6, TMEM243, TWIST1, and CSAG2) predicted cell line sensitivity to paclitaxel with 82% accuracy...
  21. Alkaissi H, Ekstrand J, Jawad A, Nielsen J, Havarinasab S, Söderkvist P, et al. Genome-Wide Association Study to Identify Genes Related to Renal Mercury Concentrations in Mice. Environ Health Perspect. 2016;124:920-6 pubmed publisher
    ..Candidate genes (Pprc1, Btrc and Nfkb2) verified by fine mapping and QTL were further investigated by real-time polymerase chain reaction...
  22. Kryl skii E, Popova T, Safonova O, Stolyarova A, Razuvaev G, de Carvalho M. Transcriptional Regulation of Antioxidant Enzymes Activity and Modulation of Oxidative Stress by Melatonin in Rats Under Cerebral Ischemia / Reperfusion Conditions. Neuroscience. 2019;: pubmed publisher
    ..activation of apoptotic processes and the accumulation of mRNA of the genes Sod1, Cat, Gpx1, Gsr, Hif-1α, Nrf2, Nfkb2, and Foxo1 in the rats' brains...
  23. Scala G, Ruocco M, Ambrosino C, Mallardo M, Giordano V, Baldassarre F, et al. The expression of the interleukin 6 gene is induced by the human immunodeficiency virus 1 TAT protein. J Exp Med. 1994;179:961-71 pubmed
    ..These results suggest that TAT protein may play a role in the pathogenesis of some HIV1-associated diseases by modulating the expression of host cellular genes. ..
  24. Li Z, Nabel G. A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription. Mol Cell Biol. 1997;17:6184-90 pubmed
    ..I kappaB epsilon interacts with different NF-kappaB proteins, including p65 (RelA), c-Rel, p50, and p52, in vitro and in vivo and inhibits the DNA-binding activity of both p50-p65 and p50-c-Rel complexes effectively...
  25. Wang Y, Xu J, Gao G, Li J, Huang H, Jin H, et al. Tumor-suppressor NFκB2 p100 interacts with ERK2 and stabilizes PTEN mRNA via inhibition of miR-494. Oncogene. 2016;35:4080-90 pubmed publisher
    Emerging evidence from The Cancer Genome Atlas has revealed that nuclear factor κB2 (nfκb2) gene encoding p100 is genetically deleted or mutated in human cancers, implicating NFκB2 as a potential tumor suppressor...
  26. Xu J, Wang Y, Hua X, Xu J, Tian Z, Jin H, et al. Inhibition of PHLPP2/cyclin D1 protein translation contributes to the tumor suppressive effect of NF?B2 (p100). Oncotarget. 2016;7:34112-30 pubmed publisher
    Although the precursor protein of NF?B2 (p100) is thought to act as a tumor suppressor in mammalian cells, the molecular mechanism of its anti-tumor activity is far from clear...
  27. Hong C, Park J, Seo K, Kim J, Im S, Lee J, et al. Expression of MIS in the testis is downregulated by tumor necrosis factor alpha through the negative regulation of SF-1 transactivation by NF-kappa B. Mol Cell Biol. 2003;23:6000-12 pubmed
    ..These results may identify, for the first time, the responsible substance and its action mechanism underlying the repression of MIS expression by meiotic germ cells in the testis. ..
  28. O Neil B, Buzkova P, Farrah H, Kashatus D, Sanoff H, Goldberg R, et al. Expression of nuclear factor-kappaB family proteins in hepatocellular carcinomas. Oncology. 2007;72:97-104 pubmed
    ..NF-kappaB p50 and p52 subunits were frequently localized to tumor cell nuclei (40 and 48%), whereas p65 positivity was infrequent...
  29. Busino L, Millman S, Pagano M. SCF-mediated degradation of p100 (NF-κB2): mechanisms and relevance in multiple myeloma. Sci Signal. 2012;5:pt14 pubmed publisher
    ..analysis of affinity purifications by mass spectrometry, we identified the nuclear factor κB (NF-κB) protein p100 (NF-κB2) as an interactor of the F-box protein FBXW7α...
  30. Mahieux R, Lambert P, Agbottah E, Halanski M, Deng L, Kashanchi F, et al. Cell cycle regulation of human interleukin-8 gene expression by the human immunodeficiency virus type 1 Tat protein. J Virol. 2001;75:1736-43 pubmed
    ..Finally, we demonstrate that the presence of the proteasome inhibitor MG-132 inhibits the induction of NF-kappa B binding, as well as IL-8 expression, supporting the role of NF-kappa B. ..
  31. Savlı H, Akkoyunlu R, Çine N, Gluzman D, Zavelevich M, Sklyarenko L, et al. Deregulated Levels of the NF-κB1, NF-κB2, and Rel Genes in Ukrainian Patients with Leukemia and Lymphoma in the Post-Chernobyl Period. Turk J Haematol. 2016;33:8-14 pubmed publisher
    ..Bu düşünceleri açıklığa kavuşturmak için daha geniş deneyler ve radyasyon maruziyeti olmayan kontrol malign hücre popülasyonlarına ihtiyaç vardır. ..
  32. Grinberg Bleyer Y, Caron R, Seeley J, De Silva N, Schindler C, Hayden M, et al. The Alternative NF-κB Pathway in Regulatory T Cell Homeostasis and Suppressive Function. J Immunol. 2018;200:2362-2371 pubmed publisher
    ..In this article, we show that conditional deletion of the p100 gene, nfkb2, in Tregs, resulted in massive inflammation because of impaired suppressive function of nfkb2-deficient ..
  33. Zhang J, Chang C, Lombardi L, Dalla Favera R. Rearranged NFKB2 gene in the HUT78 T-lymphoma cell line codes for a constitutively nuclear factor lacking transcriptional repressor functions. Oncogene. 1994;9:1931-7 pubmed
    Rearrangements of the NFKB2 gene are associated with lymphoid malignancies, but the functional significance of these alterations is not known...
  34. Amir R, Haecker H, Karin M, Ciechanover A. Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase. Oncogene. 2004;23:2540-7 pubmed
    Processing of the NF-kappa B2 precursor p100 to the mature p52 subunit is regulated via a unique pathway...
  35. Manna S, Aggarwal B. Differential requirement for p56lck in HIV-tat versus TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal kinase, and apoptosis. J Immunol. 2000;164:5156-66 pubmed
    ..Overall, our results demonstrate that p56lck plays a critical role in the activation of NF-kappa B, AP-1, JNK, and apoptosis by HIV-tat protein but has minimal or no role in activation of these responses by TNF. ..
  36. Gustin J, Korgaonkar C, Pincheira R, Li Q, Donner D. Akt regulates basal and induced processing of NF-kappaB2 (p100) to p52. J Biol Chem. 2006;281:16473-81 pubmed
    ..IKKalpha activates a non-canonical NF-kappaB pathway in which p100 (NF-kappaB2) is processed to p52...
  37. Nadiminty N, Lou W, Sun M, Chen J, Yue J, Kung H, et al. Aberrant activation of the androgen receptor by NF-kappaB2/p52 in prostate cancer cells. Cancer Res. 2010;70:3309-19 pubmed publisher
    ..In the present study, we showed that NF-kappaB/p52 can activate the AR, resulting in increased transactivation of AR-responsive genes, such as PSA and NKX3...
  38. Carroll J, Cole S, Seeman T, Breen E, Witarama T, Arevalo J, et al. Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans. Brain Behav Immun. 2016;51:223-9 pubmed publisher
    ..Gene expression changes were also observed from baseline to PSD in NFKB2, NBS1 and CHK2 (all p's<.05)...
  39. Asadikaram G, Noroozi S, Ebrahimi Meimand H, Sanjari M, Zainodini N, Khoramdelazad H, et al. Interferon-β 1a Modulates Expression of RAGE but Not S100A12 and Nuclear Factor-κB in Multiple Sclerosis Patients. Neuroimmunomodulation. 2016;23:345-351 pubmed publisher
    ..NF-κB is produced permanently in the human cells and is inactive in the cytoplasm; therefore, the effects of IFN-β 1a may be related to its functions rather than expressions. ..
  40. Qing G, Qu Z, Xiao G. Endoproteolytic processing of C-terminally truncated NF-kappaB2 precursors at kappaB-containing promoters. Proc Natl Acad Sci U S A. 2007;104:5324-9 pubmed
    The C-terminal, partially truncated forms of the NF-kappaB2/p52 precursor p100, p100DeltaCs, manifest constitutive processing and oncogenic ability, although the responsible mechanisms remain unknown...
  41. Banoth B, Chatterjee B, Vijayaragavan B, Prasad M, Roy P, Basak S. Stimulus-selective crosstalk via the NF-κB signaling system reinforces innate immune response to alleviate gut infection. elife. 2015;4: pubmed publisher
    ..Concomitant LTβR signal targeted TLR4-induced newly synthesized p100, encoded by Nfkb2, for processing into p52 that not only neutralized p100 mediated inhibitions, but potently generated RelA:p52/NF-Î..
  42. Zhu M, Chin R, Christiansen P, Lo J, Liu X, Ware C, et al. NF-kappaB2 is required for the establishment of central tolerance through an Aire-dependent pathway. J Clin Invest. 2006;116:2964-71 pubmed
    ..We further demonstrated that NF-kappaB2 was required for thymic Aire gene transcriptional regulation. The Nfkb2(-/-) thymus had distinct cortical and medullar structures, but reduced Aire and target gene expression of ..
  43. Du J, Huo J, Shi J, Yuan Z, Zhang C, Fu W, et al. Polymorphisms of nuclear factor-?B family genes are associated with development of multiple myeloma and treatment outcome in patients receiving bortezomib-based regimens. Haematologica. 2011;96:729-37 pubmed publisher
    ..In this study we analyzed 26 polymorphism sites of nuclear factor-?B family member genes, IKB?, NFKB2, and TRAF3, in 527 unrelated Chinese Han subjects (252 with multiple myeloma and 275 controls) using a Sequenom ..
  44. Di Stefano V, Wang B, Parobchak N, Roche N, Rosen T. RelB/p52-mediated NF-κB signaling alters histone acetylation to increase the abundance of corticotropin-releasing hormone in human placenta. Sci Signal. 2015;8:ra85 pubmed publisher
    ..Glucocorticoid stimulates CRH expression in full-term human placenta by promoting noncanonical (RelB/p52 heterodimer-mediated) nuclear factor κB (NF-κB) pathway activity...
  45. Mukherjee T, Chatterjee B, Dhar A, Bais S, Chawla M, Roy P, et al. A TNF-p100 pathway subverts noncanonical NF-κB signaling in inflamed secondary lymphoid organs. EMBO J. 2017;36:3501-3516 pubmed publisher
    ..Mechanistically, TNF inactivated NIK in LTβR-stimulated cells and induced the synthesis of Nfkb2 mRNA encoding p100; these together potently accumulated unprocessed p100, which attenuated the RelB activity ..
  46. Dobrzanski P, Ryseck R, Bravo R. Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity. EMBO J. 1994;13:4608-16 pubmed the other members of the family, RelB associates efficiently only with NF-kappa B1 (p105-p50) and NF-kappa B2 (p100-p52), but not with cRel or p65...
  47. Heusch M, Lin L, Geleziunas R, Greene W. The generation of nfkb2 p52: mechanism and efficiency. Oncogene. 1999;18:6201-8 pubmed
    b>nfkb2 encodes two members of the NF-kappa B/Rel family of proteins: p52 and p100. The p100 polypeptide has been proposed to serve as a precursor of p52, which corresponds to the N-terminal half of p100...
  48. Chuong C, Katz J, Pauley K, Bulosan M, Cha S. RAGE expression and NF-kappaB activation attenuated by extracellular domain of RAGE in human salivary gland cell line. J Cell Physiol. 2009;221:430-4 pubmed publisher
    ..More importantly, nuclear translocation of p65 and p52 of NF-kappaB by S100A4 was inhibited in the presence of ex-RAGE, confirming anti-inflammatory function of ex-RAGE...
  49. Krljanac B, Weih D, Jacobsen I, Hu D, Koliesnik I, Reppe K, et al. NF-?B2/p100 deficiency impairs immune responses to T-cell-independent type 2 antigens. Eur J Immunol. 2014;44:662-72 pubmed publisher
    ..Recently, we reported that unrestricted activation of this pathway in NF-?B2/p100-deficient (p100(-/-) ) knock-in mice alters the phenotype of MZ stroma and B cells...
  50. Pan W, Zhang A, Gu W, Gao J, Du D, Zhang L, et al. Identification of haplotype tag single nucleotide polymorphisms within the nuclear factor-κB family genes and their clinical relevance in patients with major trauma. Crit Care. 2015;19:95 pubmed publisher
    ..Tag SNPs (tSNPs) were selected from the NF-κB family genes (NFKB1, NFKB2, RELA, RELB and REL) through construction of haplotype blocks...
  51. Lozhkin A, Vendrov A, Pan H, Wickline S, Madamanchi N, Runge M. NADPH oxidase 4 regulates vascular inflammation in aging and atherosclerosis. J Mol Cell Cardiol. 2017;102:10-21 pubmed publisher
    ..peptide-mediated knockdown of TGFβ-activated kinase 1 (TAK1, also known as Map3k7), Jun, and Rela, but not Nfkb2, downregulated TGFβ1-induced Nox4 expression in VSMCs...
  52. Alcami J, Lain de Lera T, Folgueira L, Pedraza M, Jacque J, Bachelerie F, et al. Absolute dependence on kappa B responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4 T lymphocytes. EMBO J. 1995;14:1552-60 pubmed
    ..abstract truncated at 250 words) ..
  53. Duckett C, Perkins N, Kowalik T, Schmid R, Huang E, Baldwin A, et al. Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappa B-alpha (MAD-3). Mol Cell Biol. 1993;13:1315-22 pubmed
    ..NF-kappa B is composed of distinct subunits; five independent genes, NFKB1(p105), NFKB2(p100), RelA(p65), c-rel and relB, that encode related proteins that bind to kappa B DNA elements have been ..
  54. Cho I, Jeong S, Jhun B, An W, Lee B, Kwak Y, et al. Activation of non-canonical NF-kappaB pathway mediated by STP-A11, an oncoprotein of Herpesvirus saimiri. Virology. 2007;359:37-45 pubmed publisher
    ..We herein report that STP-A11 activates non-canonical NF-kappaB pathway, resulting in p100 processing to p52...
  55. Higuchi M, Tsubata C, Kondo R, Yoshida S, Takahashi M, Oie M, et al. Cooperation of NF-kappaB2/p100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV-1) Tax1 but not HTLV-2 Tax2 is crucial for interleukin-2-independent growth transformation of a T-cell line. J Virol. 2007;81:11900-7 pubmed
    ..In this study, we demonstrate that Tax1 but not Tax2 interacts with NF-kappaB2/p100 and activates it by inducing the cleavage of p100 into the active transcription factor p52...
  56. Thaker K, Chwa M, Atilano S, Coskun P, Cáceres Del Carpio J, Udar N, et al. Increased expression of ApoE and protection from amyloid-beta toxicity in transmitochondrial cybrids with haplogroup K mtDNA. Neurobiol Dis. 2016;93:64-77 pubmed publisher
    ..Other cybrids were demethylated with 5-aza-2'-deoxycytidine (5-aza-dC) and expression levels for APOE and NFkB2 were measured...
  57. Guo X, Koff J, Moffitt A, Cinar M, Ramachandiran S, Chen Z, et al. Molecular impact of selective NFKB1 and NFKB2 signaling on DLBCL phenotype. Oncogene. 2017;36:4224-4232 pubmed publisher
    ..Application of novel gene expression classifiers identified two new DLBCL categories characterized by selective p100 (NF-κB2) and p105 (NF-κB1) signaling...
  58. Westendorp M, Shatrov V, Schulze Osthoff K, Frank R, Kraft M, Los M, et al. HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state. EMBO J. 1995;14:546-54 pubmed
    ..abstract truncated at 250 words) ..
  59. Kundu M, Sharma S, De Luca A, Giordano A, Rappaport J, Khalili K, et al. HIV-1 Tat elongates the G1 phase and indirectly promotes HIV-1 gene expression in cells of glial origin. J Biol Chem. 1998;273:8130-6 pubmed
    ..The significance of these findings relates to the current hypothesis that indirect effects of HIV-1 infection of the CNS may contribute to the neurological complications associated with AIDS dementia complex. ..
  60. Munzert G, Kreitmeier S, Bergmann L. Normal structure of NFKB2, C-REL and BCL-3 gene loci in lymphoproliferative and myeloproliferative disorders. Leuk Lymphoma. 2000;38:395-400 pubmed
    ..Our results demonstrate that structural alterations of NFkappaB2, c-rel and bcl-3 genes at the Southern Blotting level are rare events that do not contribute to lymphoid or myeloid transformation in the majority of NHL or cMPS patients. ..
  61. Fagerlund R, Kinnunen L, Kohler M, Julkunen I, Melen K. NF-{kappa}B is transported into the nucleus by importin {alpha}3 and importin {alpha}4. J Biol Chem. 2005;280:15942-51 pubmed
    ..The present study demonstrates that the nuclear import of NF-kappaB is a highly regulated process mediated by a subset of importin alpha molecules. ..
  62. Lessard L, Saad F, Le Page C, Diallo J, Péant B, Delvoye N, et al. NF-kappaB2 processing and p52 nuclear accumulation after androgenic stimulation of LNCaP prostate cancer cells. Cell Signal. 2007;19:1093-100 pubmed
    ..LNCaP cells with the androgen analogue R1881 appears to positively regulate the non-canonical NF-kappaB pathway as p52 accumulates both in the cytoplasm and nucleus after 48-72 h of stimulation...
  63. Bigildeev A, Zezina E, Drize N. [The effects of interleukin-1 beta and gamma-quantum braking radiation on mesenchymal progenitor cells]. Mol Biol (Mosk). 2017;51:447-459 pubmed publisher
    ..These results indicate an important role of Rel, Rela, Relb, and Nfkb2 genes in the induction of IL-1? signal pathway in murine stromal cells...
  64. Beauparlant P, Kwon H, Clarke M, Lin R, Sonenberg N, Wainberg M, et al. Transdominant mutants of I kappa B alpha block Tat-tumor necrosis factor synergistic activation of human immunodeficiency virus type 1 gene expression and virus multiplication. J Virol. 1996;70:5777-85 pubmed
    ..These experiments suggest a strategy that may contribute to inhibition of HIV-1 gene expression by interfering with the NF-kappa B/Rel signaling pathway. ..
  65. Al Sadi R, Ye D, Said H, Ma T. IL-1beta-induced increase in intestinal epithelial tight junction permeability is mediated by MEKK-1 activation of canonical NF-kappaB pathway. Am J Pathol. 2010;177:2310-22 pubmed publisher
    ..In conclusion, our data show for the first time that MEKK-1 plays an integral role in IL-1? modulation of Caco-2 TJ barrier function by regulating the activation of the canonical NF-?B pathway and the MLCK gene. ..
  66. Liu Y, Hanson S, Gurugama P, Jones A, Clark B, Ibrahim M. Novel NFKB2 mutation in early-onset CVID. J Clin Immunol. 2014;34:686-90 pubmed publisher
    ..Whole exome sequencing revealed 8bp deletion in the C-terminal part of NFKB2 gene associated with disease. The mutation leads to a frameshift (p...
  67. Mao A, Shen J, Zuo Z. Expression and regulation of long noncoding RNAs in TLR4 signaling in mouse macrophages. BMC Genomics. 2015;16:45 pubmed publisher
    ..Crucially, many identified LPS-regulated lncRNAs, such as lncRNA-Nfkb2 and lncRNA-Rel, locate near to immune response protein-coding genes...
  68. Wang J, Qi X, Zhang X, Yan W, You C. [Genetic polymorphisms of ARL15 and HLA-DMA are associated with rheumatoid arthritis in Han population from northwest China]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33:1681-1685 pubmed
    ..15 (ARL15), major histocompatibility complex class II-DM alpha (HLA-DMA ) and nuclear factor kappa B subunit 2 (NFKB2) genes using high resolution melting (HRM) technology, and to explore the association of those SNPs with the ..
  69. Lwin T, Hazlehurst L, Li Z, Dessureault S, Sotomayor E, Moscinski L, et al. Bone marrow stromal cells prevent apoptosis of lymphoma cells by upregulation of anti-apoptotic proteins associated with activation of NF-kappaB (RelB/p52) in non-Hodgkin's lymphoma cells. Leukemia. 2007;21:1521-31 pubmed
    ..This DNA binding activity could be attributed to cell adhesion-mediated proteolysis of the NF-kappaB precursor, p100 (NF-kappaB2)...
  70. Dieguez Gonzalez R, Akar S, Calaza M, Perez Pampin E, Costas J, Torres M, et al. Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. Ann Rheum Dis. 2009;68:579-83 pubmed publisher
    ..uniformly spaced along the genomic sequences of 17 core genes of the NFkappaB pathway (REL, RELA, RELB, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, IKBKA, IKBKB, IKBKE, IKBKAP, KBRAS1, KBRAS2, MAP3K1, MAP3K14, TAX1BP1) were studied by ..
  71. Willmann K, Sacco R, Martins R, Garncarz W, Krolo A, Knapp S, et al. Expanding the Interactome of the Noncanonical NF-?B Signaling Pathway. J Proteome Res. 2016;15:2900-2909 pubmed publisher
    ..interaction network including the noncanonical NF-?B signaling nodes TRAF2, TRAF3, IKK?, NIK, and NF-?B2/p100. The value of the data set was confirmed by the identification of interactions already known to regulate this ..
  72. Wang V, Li Y, Kim D, Zhong X, Du Q, Ghassemian M, et al. Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity. Mol Cell. 2017;67:484-497.e5 pubmed publisher
    ..of NF-κB RelA, cRel, and RelB dimers, the atypical IκB protein Bcl3 is primarily a transcriptional coregulator of p52 and p50 homodimers. Bcl3 exists as phospho-protein in many cancer cells...
  73. Schmid R, Perkins N, Duckett C, Andrews P, Nabel G. Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65. Nature. 1991;352:733-6 pubmed
    ..It is synthesized as approximately 100K protein (p100) that is expressed in different cell types, contains cell cycle motifs and, like p105, must be processed to ..
  74. Nonaka M, Horie R, Itoh K, Watanabe T, Yamamoto N, Yamaoka S. Aberrant NF-kappaB2/p52 expression in Hodgkin/Reed-Sternberg cells and CD30-transformed rat fibroblasts. Oncogene. 2005;24:3976-86 pubmed
    ..Kinetic studies revealed that a proteasome inhibitor MG132 induced p100 accumulation with reduced p52 expression in H-RS cells, suggesting proteasome-dependent processing of p100...
  75. Nadiminty N, Chun J, Lou W, Lin X, Gao A. NF-kappaB2/p52 enhances androgen-independent growth of human LNCaP cells via protection from apoptotic cell death and cell cycle arrest induced by androgen-deprivation. Prostate. 2008;68:1725-33 pubmed publisher
    ..In this study, we employed in vitro as well as in vivo models to examine the role of NF-kappaB2/p52 in prostate cancer growth and androgen independent progression...
  76. Miaskowski C, Cataldo J, Baggott C, West C, Dunn L, Dhruva A, et al. Cytokine gene variations associated with trait and state anxiety in oncology patients and their family caregivers. Support Care Cancer. 2015;23:953-65 pubmed publisher
    ..e., interleukin (IL) 1 beta, IL1 receptor 2 (IL1R2), nuclear factor kappa beta 2 (NFKB2)) were associated with trait anxiety, and variations in two genes (i.e...
  77. Wong S, Chou H, Chao C, Leung J, Chen Y, Hsu C. Distal 10q trisomy with copy number gain in chromosome region 10q23.1-10q25.1: the Wnt signaling pathway is the most pertinent to the gene content in the region of copy number gain: a case report. BMC Res Notes. 2015;8:250 pubmed publisher
    ..A change in the expression levels of some Wnt signaling pathway components and of NFKB2 and PTEN genes due to a gain in their gene copy number may be associated with the patient's clinical outcomes ..
  78. Wood M, Rios D, Williams I. TNF-? augments RANKL-dependent intestinal M cell differentiation in enteroid cultures. Am J Physiol Cell Physiol. 2016;311:C498-507 pubmed publisher
    ..One contributing mechanism is the rapid induction by TNF-? of Relb and Nfkb2 (NF-?B subunit 2), genes encoding the two subunits of the noncanonical NF-?B heterodimer...
  79. Kuehn H, Niemela J, Sreedhara K, Stoddard J, Grossman J, Wysocki C, et al. Novel nonsense gain-of-function NFKB2 mutations associated with a combined immunodeficiency phenotype. Blood. 2017;130:1553-1564 pubmed publisher
    NF-?B signaling through its NFKB1-dependent canonical and NFKB2-dependent noncanonical pathways plays distinctive roles in a diverse range of immune processes...
  80. Beg A, Baldwin A. Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor. Oncogene. 1994;9:1487-92 pubmed
    ..recent studies have led to the identification of other kappa B binding proteins such as c-Rel, RelB and p52 (NFKB2/lyt-10) although their role in gene regulation has been less clear...
  81. Annunziata C, Davis R, Demchenko Y, Bellamy W, Gabrea A, Zhan F, et al. Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell. 2007;12:115-30 pubmed
    ..often associated with genetic or epigenetic alteration of NIK, TRAF3, CYLD, BIRC2/BIRC3, CD40, NFKB1, or NFKB2. These data demonstrate that addiction to the NF-kappaB pathway is frequent in myeloma and suggest that IKKbeta ..
  82. Ledoux A, Sellier H, Gillies K, Iannetti A, James J, Perkins N. NF?B regulates expression of Polo-like kinase 4. Cell Cycle. 2013;12:3052-62 pubmed publisher
    ..Significantly long-term deletion of the NF?B2 (p100/p52) subunit leads to defects in centrosome structure...
  83. Laman A, Lathe R, Savinov G, Shepelyakovskaya A, Boziev K, Baidakova L, et al. Innate immunity: Bacterial cell-wall muramyl peptide targets the conserved transcription factor YB-1. FEBS Lett. 2015;589:1819-24 pubmed publisher
    ..Furthermore, YB-1 knockdown abolished GMDP-induced Nfkb2 expression...
  84. Ott M, Lovett J, Mueller L, Verdin E. Superinduction of IL-8 in T cells by HIV-1 Tat protein is mediated through NF-kappaB factors. J Immunol. 1998;160:2872-80 pubmed
    ..The effect of Tat101 on CD28REs in the IL-8 promoter and the subsequent up-regulation of IL-8 secretion is likely to contribute to the immune dysregulation observed during HIV-1 infection. ..
  85. Liu J, Perkins N, Schmid R, Nabel G. Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription. J Virol. 1992;66:3883-7 pubmed
    ..These findings suggest that the combination of p49(100) and p65 NF-kappa B can act in concert with the tat-I gene product to stimulate the synthesis of HIV RNA. ..
  86. Fong A, Zhang M, Neely J, Sun S. S9, a 19 S proteasome subunit interacting with ubiquitinated NF-kappaB2/p100. J Biol Chem. 2002;277:40697-702 pubmed
    Proteasome-mediated processing of the nfkappab2 gene product p100 is a regulated event that generates the NF-kappaB subunit p52...
  87. Knyazev E, Mal tseva D, Zacharyants A, Zakharova G, Zhidkova O, Poloznikov A. TNF?-Induced Expression of Transport Protein Genes in HUVEC Cells Is Associated with Enhanced Expression of Transcription Factor Genes RELB and NFKB2 of the Non-Canonical NF-?B Pathway. Bull Exp Biol Med. 2018;164:757-761 pubmed publisher
    ..SLC12A2, SLC9B2, SLC25A37, and SLC41A2 genes have binding sites for transcriptional factor RelB that together with NFKB2 is the main effector of the non-canonical NF-?B pathway...
  88. Wang J, Ferreira R, Lu W, Farrow S, Downes K, Jermutus L, et al. TNFR2 ligation in human T regulatory cells enhances IL2-induced cell proliferation through the non-canonical NF-?B pathway. Sci Rep. 2018;8:12079 pubmed publisher
    ..RNA-seq analysis of TNF- or D18-treated human T regs revealed that TNFR2 ligation induces transcription of NFKB2 and RELB, encoding proteins that form the non-canonical NF-?B transcription factor...
  89. Nadiminty N, Tummala R, Liu C, Lou W, Evans C, Gao A. NF-κB2/p52:c-Myc:hnRNPA1 Pathway Regulates Expression of Androgen Receptor Splice Variants and Enzalutamide Sensitivity in Prostate Cancer. Mol Cancer Ther. 2015;14:1884-95 pubmed publisher overexpressed in prostate tumors compared with benign prostates, and its expression is regulated by NF-κB2/p52 and c-Myc. CRPC cells resistant to enzalutamide exhibit higher levels of NF-κB2/p52, c-Myc, hnRNPA1, and AR-V7...
  90. Chauhan A, Hahn S, Gartner S, Pardo C, Netesan S, McArthur J, et al. Molecular programming of endothelin-1 in HIV-infected brain: role of Tat in up-regulation of ET-1 and its inhibition by statins. FASEB J. 2007;21:777-89 pubmed
    ..Our findings suggest that ET-1 may be critical in mediating the neuropathogenesis of HIV dementia and that statins may have therapeutic potential in these patients. ..