Gene Symbol: NFKB2
Description: nuclear factor kappa B subunit 2
Alias: CVID10, H2TF1, LYT-10, LYT10, NF-kB2, p100, p49/p100, p52, nuclear factor NF-kappa-B p100 subunit, DNA-binding factor KBF2, NFKB, p52/p100 subunit, lymphocyte translocation chromosome 10 protein, nuclear factor Kappa-B, subunit 2, nuclear factor NF-kappa-B p52 subunit, nuclear factor of Kappa light chain gene enhancer in B cells 2, nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100), oncogene Lyt-10, transcription factor NFKB2
Species: human
Products:     NFKB2

Top Publications

  1. Neri A, Chang C, Lombardi L, Salina M, Corradini P, Maiolo A, et al. B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappa B p50. Cell. 1991;67:1075-87 pubmed
    ..The lyt-10 gene defines a new subfamily (rel/poly-G/ankyrin) of NF-kappa B-rel transcription factors with potential for oncogenic activation in human cancer. ..
  2. Conant K, Ma M, Nath A, Major E. Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes. J Virol. 1996;70:1384-9 pubmed
    ..These effects include Tat's ability to upregulate the synthesis of specific cytokines and to act as a growth factor. ..
  3. Baldwin A. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol. 1996;14:649-83 pubmed
  4. Xiao G, Harhaj E, Sun S. NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol Cell. 2001;7:401-9 pubmed
    Processing of the nf(kappa)b2 gene product p100 to generate p52 is an important step in NF-kappaB regulation...
  5. Sheng W, Hu S, Lokensgard J, Peterson P. U50,488 inhibits HIV-1 Tat-induced monocyte chemoattractant protein-1 (CCL2) production by human astrocytes. Biochem Pharmacol. 2003;65:9-14 pubmed
    ..These findings suggest that KOR ligands could have an anti-inflammatory effect in the CNS and thereby be beneficial in the treatment of HIV-1-associated brain disease. ..
  6. Derudder E, Laferté A, Ferreira V, Mishal Z, Baud V, Tarantino N, et al. Identification and characterization of p100HB, a new mutant form of p100/NF-kappa B2. Biochem Biophys Res Commun. 2003;308:744-9 pubmed
    b>P100, which is encoded by NF-kappa B2, inhibits Rel dimers. It can also be processed into p52, one of the DNA binding sub-units of NF-kappa B/Rel factors...
  7. Nadiminty N, Lou W, Lee S, Lin X, Trump D, Gao A. Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation. Proc Natl Acad Sci U S A. 2006;103:7264-9 pubmed
    Activation of the noncanonical NF-kappaB signaling pathway involved in the proteolytic processing of NF-kappaB p100 to p52 is tightly regulated, and overproduction of p52 leads to lymphocyte hyperplasia and transformation...
  8. Basak S, Kim H, Kearns J, Tergaonkar V, O Dea E, Werner S, et al. A fourth IkappaB protein within the NF-kappaB signaling module. Cell. 2007;128:369-81 pubmed
    ..We report here the characterization of a fourth inhibitor, nfkappab2/p100, that forms two distinct inhibitory complexes with RelA, one of which mediates developmental NF-kappaB activation...
  9. Migliazza A, Lombardi L, Rocchi M, Trecca D, Chang C, Antonacci R, et al. Heterogeneous chromosomal aberrations generate 3' truncations of the NFKB2/lyt-10 gene in lymphoid malignancies. Blood. 1994;84:3850-60 pubmed
    The NFKB2(lyt-10) gene codes for a protein that is a member of the NK-kappa B/rel family of transcription factors containing a DNA-binding rel domain and a carboxy-terminal ankyrin-like domain...

More Information

Publications137 found, 100 shown here

  1. Liptay S, Schmid R, Nabel E, Nabel G. Transcriptional regulation of NF-kappa B2: evidence for kappa B-mediated positive and negative autoregulation. Mol Cell Biol. 1994;14:7695-703 pubmed
    ..In contrast to other family members, we find that kappa B elements in the NFKB2 promoter can also mediate transcriptional repression in the absence of NF-kappa B...
  2. Thakur S, Lin H, Tseng W, Kumar S, Bravo R, Foss F, et al. Rearrangement and altered expression of the NFKB-2 gene in human cutaneous T-lymphoma cells. Oncogene. 1994;9:2335-44 pubmed
    ..DNA sequence predicted the presence of a truncated 80 kD NFKB-2 precursor protein (p80HT), instead of the normal p100 protein. No wild-type allele was identified...
  3. Chen F, Castranova V, Shi X, Demers L. New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases. Clin Chem. 1999;45:7-17 pubmed
    ..Therefore, development of modulatory strategies targeting this transcription factor may provide a novel therapeutic tool for the treatment or prevention of various diseases. ..
  4. Rocha S, Martin A, Meek D, Perkins N. p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1. Mol Cell Biol. 2003;23:4713-27 pubmed
    ..was dependent on the proximal NF-kappaB binding site of the cyclin D1 promoter, which has been shown to bind the p52 NF-kappaB subunit...
  5. Liang C, Zhang M, Sun S. beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870. Cell Signal. 2006;18:1309-17 pubmed
    Processing of the NF-kappaB2 precursor protein p100 is a major step in noncanonical NF-kappaB signaling. This signaling step requires the NF-kappaB inducing kinase (NIK) and its downstream kinase, IkappaB kinase alpha (IKKalpha)...
  6. Bernal Mizrachi L, Lovly C, Ratner L. The role of NF-{kappa}B-1 and NF-{kappa}B-2-mediated resistance to apoptosis in lymphomas. Proc Natl Acad Sci U S A. 2006;103:9220-5 pubmed
    ..These findings demonstrate an important role of both NF-kappaB pathways in mediating resistance to apoptosis and distinctive antiapoptotic downstream target gene profiles responsible for this effect. ..
  7. Schumm K, Rocha S, Caamano J, Perkins N. Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit. EMBO J. 2006;25:4820-32 pubmed
    The p52/p100 nuclear factor kappa B (NF-kappaB) subunit (NF-kappaB2) is aberrantly expressed in many tumour types and has been implicated as a regulator of cell proliferation...
  8. Vallabhapurapu S, Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol. 2009;27:693-733 pubmed publisher
    ..including RelA, c-Rel, RelB, NF-kappaB1 (p50 and its precursor p105), and NF-kappaB2 (p52 and its precursor p100), plays a central role in the immune system by regulating several processes ranging from the development and ..
  9. Busino L, Millman S, Scotto L, Kyratsous C, Basrur V, O CONNOR O, et al. Fbxw7?- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma. Nat Cell Biol. 2012;14:375-85 pubmed publisher
    ..Using differential purifications and mass spectrometry, we identified p100, an inhibitor of NF-?B signalling, as an interactor of Fbxw7?...
  10. Chen K, Coonrod E, Kumanovics A, Franks Z, Durtschi J, Margraf R, et al. Germline mutations in NFKB2 implicate the noncanonical NF-?B pathway in the pathogenesis of common variable immunodeficiency. Am J Hum Genet. 2013;93:812-24 pubmed publisher
    ..2564delA (p.Lys855Serfs(?)7), in NFKB2 affecting the C terminus of NF-?B2 (also known as p100/p52 or p100/p49)...
  11. Fracchiolla N, Lombardi L, Salina M, Migliazza A, Baldini L, Berti E, et al. Structural alterations of the NF-kappa B transcription factor lyt-10 in lymphoid malignancies. Oncogene. 1993;8:2839-45 pubmed
    ..This gene, called lyt-10 (NFKB2/p52), is a member of the NF-kappa B family of transcription factors and displays a high degree of homology with ..
  12. Neri A, Fracchiolla N, Migliazza A, Trecca D, Lombardi L. The involvement of the candidate proto-oncogene NFKB2/lyt-10 in lymphoid malignancies. Leuk Lymphoma. 1996;23:43-8 pubmed
    ..Two subunits, NF-kappa B1p50 and NF-kappa B2p52, coded respectively by the NFKB1 and NFKB2 genes, may only have DNA binding activity...
  13. Kim K, Gu C, Thakur S, Vieira E, Lin J, Rabson A. Transcriptional regulatory effects of lymphoma-associated NFKB2/lyt10 protooncogenes. Oncogene. 2000;19:1334-45 pubmed
    C-terminal truncations of the NFKB2 p100 gene product have been observed in a number of cases of human cutaneous T cell lymphomas, as well as human B-cell lymphomas and myelomas...
  14. Wang Y, Cui H, Schroering A, Ding J, Lane W, McGill G, et al. NF-kappa B2 p100 is a pro-apoptotic protein with anti-oncogenic function. Nat Cell Biol. 2002;4:888-93 pubmed
    ..The only NF-kappa B family member known to be mutated in human cancer is NF-kappa B2 p100 (ref. 2), a factor with I kappa B activity...
  15. Qing G, Xiao G. Essential role of IkappaB kinase alpha in the constitutive processing of NF-kappaB2 p100. J Biol Chem. 2005;280:9765-8 pubmed
    Processing of NF-kappaB2 precursor protein p100 to generate p52 is tightly controlled, which is important for proper function of NF-kappaB...
  16. Qing G, Qu Z, Xiao G. Stabilization of basally translated NF-kappaB-inducing kinase (NIK) protein functions as a molecular switch of processing of NF-kappaB2 p100. J Biol Chem. 2005;280:40578-82 pubmed
    The non-canonical pathway based on processing of NF-kappaB2 precursor protein p100 to generate p52 plays a critical role in controlling B cell function and lymphoid organogenesis...
  17. Westendorp M, Shatrov V, Schulze Osthoff K, Frank R, Kraft M, Los M, et al. HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state. EMBO J. 1995;14:546-54 pubmed
    ..abstract truncated at 250 words) ..
  18. Kundu M, Sharma S, De Luca A, Giordano A, Rappaport J, Khalili K, et al. HIV-1 Tat elongates the G1 phase and indirectly promotes HIV-1 gene expression in cells of glial origin. J Biol Chem. 1998;273:8130-6 pubmed
    ..The significance of these findings relates to the current hypothesis that indirect effects of HIV-1 infection of the CNS may contribute to the neurological complications associated with AIDS dementia complex. ..
  19. Munzert G, Kreitmeier S, Bergmann L. Normal structure of NFKB2, C-REL and BCL-3 gene loci in lymphoproliferative and myeloproliferative disorders. Leuk Lymphoma. 2000;38:395-400 pubmed
    ..Our results demonstrate that structural alterations of NFkappaB2, c-rel and bcl-3 genes at the Southern Blotting level are rare events that do not contribute to lymphoid or myeloid transformation in the majority of NHL or cMPS patients. ..
  20. Fagerlund R, Kinnunen L, Kohler M, Julkunen I, Melen K. NF-{kappa}B is transported into the nucleus by importin {alpha}3 and importin {alpha}4. J Biol Chem. 2005;280:15942-51 pubmed
    ..The present study demonstrates that the nuclear import of NF-kappaB is a highly regulated process mediated by a subset of importin alpha molecules. ..
  21. Lessard L, Saad F, Le Page C, Diallo J, Péant B, Delvoye N, et al. NF-kappaB2 processing and p52 nuclear accumulation after androgenic stimulation of LNCaP prostate cancer cells. Cell Signal. 2007;19:1093-100 pubmed
    ..LNCaP cells with the androgen analogue R1881 appears to positively regulate the non-canonical NF-kappaB pathway as p52 accumulates both in the cytoplasm and nucleus after 48-72 h of stimulation...
  22. Bigildeev A, Zezina E, Drize N. [The effects of interleukin-1 beta and gamma-quantum braking radiation on mesenchymal progenitor cells]. Mol Biol (Mosk). 2017;51:447-459 pubmed publisher
    ..These results indicate an important role of Rel, Rela, Relb, and Nfkb2 genes in the induction of IL-1? signal pathway in murine stromal cells...
  23. Beauparlant P, Kwon H, Clarke M, Lin R, Sonenberg N, Wainberg M, et al. Transdominant mutants of I kappa B alpha block Tat-tumor necrosis factor synergistic activation of human immunodeficiency virus type 1 gene expression and virus multiplication. J Virol. 1996;70:5777-85 pubmed
    ..These experiments suggest a strategy that may contribute to inhibition of HIV-1 gene expression by interfering with the NF-kappa B/Rel signaling pathway. ..
  24. Al Sadi R, Ye D, Said H, Ma T. IL-1beta-induced increase in intestinal epithelial tight junction permeability is mediated by MEKK-1 activation of canonical NF-kappaB pathway. Am J Pathol. 2010;177:2310-22 pubmed publisher
    ..In conclusion, our data show for the first time that MEKK-1 plays an integral role in IL-1? modulation of Caco-2 TJ barrier function by regulating the activation of the canonical NF-?B pathway and the MLCK gene. ..
  25. Liu Y, Hanson S, Gurugama P, Jones A, Clark B, Ibrahim M. Novel NFKB2 mutation in early-onset CVID. J Clin Immunol. 2014;34:686-90 pubmed publisher
    ..Whole exome sequencing revealed 8bp deletion in the C-terminal part of NFKB2 gene associated with disease. The mutation leads to a frameshift (p...
  26. Mao A, Shen J, Zuo Z. Expression and regulation of long noncoding RNAs in TLR4 signaling in mouse macrophages. BMC Genomics. 2015;16:45 pubmed publisher
    ..Crucially, many identified LPS-regulated lncRNAs, such as lncRNA-Nfkb2 and lncRNA-Rel, locate near to immune response protein-coding genes...
  27. Wang J, Qi X, Zhang X, Yan W, You C. [Genetic polymorphisms of ARL15 and HLA-DMA are associated with rheumatoid arthritis in Han population from northwest China]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33:1681-1685 pubmed
    ..15 (ARL15), major histocompatibility complex class II-DM alpha (HLA-DMA ) and nuclear factor kappa B subunit 2 (NFKB2) genes using high resolution melting (HRM) technology, and to explore the association of those SNPs with the ..
  28. Lwin T, Hazlehurst L, Li Z, Dessureault S, Sotomayor E, Moscinski L, et al. Bone marrow stromal cells prevent apoptosis of lymphoma cells by upregulation of anti-apoptotic proteins associated with activation of NF-kappaB (RelB/p52) in non-Hodgkin's lymphoma cells. Leukemia. 2007;21:1521-31 pubmed
    ..This DNA binding activity could be attributed to cell adhesion-mediated proteolysis of the NF-kappaB precursor, p100 (NF-kappaB2)...
  29. Dieguez Gonzalez R, Akar S, Calaza M, Perez Pampin E, Costas J, Torres M, et al. Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. Ann Rheum Dis. 2009;68:579-83 pubmed publisher
    ..uniformly spaced along the genomic sequences of 17 core genes of the NFkappaB pathway (REL, RELA, RELB, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, IKBKA, IKBKB, IKBKE, IKBKAP, KBRAS1, KBRAS2, MAP3K1, MAP3K14, TAX1BP1) were studied by ..
  30. Willmann K, Sacco R, Martins R, Garncarz W, Krolo A, Knapp S, et al. Expanding the Interactome of the Noncanonical NF-?B Signaling Pathway. J Proteome Res. 2016;15:2900-2909 pubmed publisher
    ..interaction network including the noncanonical NF-?B signaling nodes TRAF2, TRAF3, IKK?, NIK, and NF-?B2/p100. The value of the data set was confirmed by the identification of interactions already known to regulate this ..
  31. Wang V, Li Y, Kim D, Zhong X, Du Q, Ghassemian M, et al. Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity. Mol Cell. 2017;67:484-497.e5 pubmed publisher
    ..of NF-?B RelA, cRel, and RelB dimers, the atypical I?B protein Bcl3 is primarily a transcriptional coregulator of p52 and p50 homodimers. Bcl3 exists as phospho-protein in many cancer cells...
  32. Schmid R, Perkins N, Duckett C, Andrews P, Nabel G. Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65. Nature. 1991;352:733-6 pubmed
    ..It is synthesized as approximately 100K protein (p100) that is expressed in different cell types, contains cell cycle motifs and, like p105, must be processed to ..
  33. Nonaka M, Horie R, Itoh K, Watanabe T, Yamamoto N, Yamaoka S. Aberrant NF-kappaB2/p52 expression in Hodgkin/Reed-Sternberg cells and CD30-transformed rat fibroblasts. Oncogene. 2005;24:3976-86 pubmed
    ..Kinetic studies revealed that a proteasome inhibitor MG132 induced p100 accumulation with reduced p52 expression in H-RS cells, suggesting proteasome-dependent processing of p100...
  34. Nadiminty N, Chun J, Lou W, Lin X, Gao A. NF-kappaB2/p52 enhances androgen-independent growth of human LNCaP cells via protection from apoptotic cell death and cell cycle arrest induced by androgen-deprivation. Prostate. 2008;68:1725-33 pubmed publisher
    ..In this study, we employed in vitro as well as in vivo models to examine the role of NF-kappaB2/p52 in prostate cancer growth and androgen independent progression...
  35. Miaskowski C, Cataldo J, Baggott C, West C, Dunn L, Dhruva A, et al. Cytokine gene variations associated with trait and state anxiety in oncology patients and their family caregivers. Support Care Cancer. 2015;23:953-65 pubmed publisher
    ..e., interleukin (IL) 1 beta, IL1 receptor 2 (IL1R2), nuclear factor kappa beta 2 (NFKB2)) were associated with trait anxiety, and variations in two genes (i.e...
  36. Wong S, Chou H, Chao C, Leung J, Chen Y, Hsu C. Distal 10q trisomy with copy number gain in chromosome region 10q23.1-10q25.1: the Wnt signaling pathway is the most pertinent to the gene content in the region of copy number gain: a case report. BMC Res Notes. 2015;8:250 pubmed publisher
    ..A change in the expression levels of some Wnt signaling pathway components and of NFKB2 and PTEN genes due to a gain in their gene copy number may be associated with the patient's clinical outcomes ..
  37. Wood M, Rios D, Williams I. TNF-? augments RANKL-dependent intestinal M cell differentiation in enteroid cultures. Am J Physiol Cell Physiol. 2016;311:C498-507 pubmed publisher
    ..One contributing mechanism is the rapid induction by TNF-? of Relb and Nfkb2 (NF-?B subunit 2), genes encoding the two subunits of the noncanonical NF-?B heterodimer...
  38. Kuehn H, Niemela J, Sreedhara K, Stoddard J, Grossman J, Wysocki C, et al. Novel nonsense gain-of-function NFKB2 mutations associated with a combined immunodeficiency phenotype. Blood. 2017;130:1553-1564 pubmed publisher
    NF-?B signaling through its NFKB1-dependent canonical and NFKB2-dependent noncanonical pathways plays distinctive roles in a diverse range of immune processes...
  39. Beg A, Baldwin A. Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor. Oncogene. 1994;9:1487-92 pubmed
    ..recent studies have led to the identification of other kappa B binding proteins such as c-Rel, RelB and p52 (NFKB2/lyt-10) although their role in gene regulation has been less clear...
  40. Annunziata C, Davis R, Demchenko Y, Bellamy W, Gabrea A, Zhan F, et al. Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell. 2007;12:115-30 pubmed
    ..often associated with genetic or epigenetic alteration of NIK, TRAF3, CYLD, BIRC2/BIRC3, CD40, NFKB1, or NFKB2. These data demonstrate that addiction to the NF-kappaB pathway is frequent in myeloma and suggest that IKKbeta ..
  41. Ledoux A, Sellier H, Gillies K, Iannetti A, James J, Perkins N. NF?B regulates expression of Polo-like kinase 4. Cell Cycle. 2013;12:3052-62 pubmed publisher
    ..Significantly long-term deletion of the NF?B2 (p100/p52) subunit leads to defects in centrosome structure...
  42. Laman A, Lathe R, Savinov G, Shepelyakovskaya A, Boziev K, Baidakova L, et al. Innate immunity: Bacterial cell-wall muramyl peptide targets the conserved transcription factor YB-1. FEBS Lett. 2015;589:1819-24 pubmed publisher
    ..Furthermore, YB-1 knockdown abolished GMDP-induced Nfkb2 expression...
  43. Ott M, Lovett J, Mueller L, Verdin E. Superinduction of IL-8 in T cells by HIV-1 Tat protein is mediated through NF-kappaB factors. J Immunol. 1998;160:2872-80 pubmed
    ..The effect of Tat101 on CD28REs in the IL-8 promoter and the subsequent up-regulation of IL-8 secretion is likely to contribute to the immune dysregulation observed during HIV-1 infection. ..
  44. Liu J, Perkins N, Schmid R, Nabel G. Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription. J Virol. 1992;66:3883-7 pubmed
    ..These findings suggest that the combination of p49(100) and p65 NF-kappa B can act in concert with the tat-I gene product to stimulate the synthesis of HIV RNA. ..
  45. Fong A, Zhang M, Neely J, Sun S. S9, a 19 S proteasome subunit interacting with ubiquitinated NF-kappaB2/p100. J Biol Chem. 2002;277:40697-702 pubmed
    Proteasome-mediated processing of the nfkappab2 gene product p100 is a regulated event that generates the NF-kappaB subunit p52...
  46. Knyazev E, Mal tseva D, Zacharyants A, Zakharova G, Zhidkova O, Poloznikov A. TNF?-Induced Expression of Transport Protein Genes in HUVEC Cells Is Associated with Enhanced Expression of Transcription Factor Genes RELB and NFKB2 of the Non-Canonical NF-?B Pathway. Bull Exp Biol Med. 2018;164:757-761 pubmed publisher
    ..SLC12A2, SLC9B2, SLC25A37, and SLC41A2 genes have binding sites for transcriptional factor RelB that together with NFKB2 is the main effector of the non-canonical NF-?B pathway...
  47. Wang J, Ferreira R, Lu W, Farrow S, Downes K, Jermutus L, et al. TNFR2 ligation in human T regulatory cells enhances IL2-induced cell proliferation through the non-canonical NF-?B pathway. Sci Rep. 2018;8:12079 pubmed publisher
    ..RNA-seq analysis of TNF- or D18-treated human T regs revealed that TNFR2 ligation induces transcription of NFKB2 and RELB, encoding proteins that form the non-canonical NF-?B transcription factor...
  48. Nadiminty N, Tummala R, Liu C, Lou W, Evans C, Gao A. NF-κB2/p52:c-Myc:hnRNPA1 Pathway Regulates Expression of Androgen Receptor Splice Variants and Enzalutamide Sensitivity in Prostate Cancer. Mol Cancer Ther. 2015;14:1884-95 pubmed publisher overexpressed in prostate tumors compared with benign prostates, and its expression is regulated by NF-κB2/p52 and c-Myc. CRPC cells resistant to enzalutamide exhibit higher levels of NF-κB2/p52, c-Myc, hnRNPA1, and AR-V7...
  49. Chauhan A, Hahn S, Gartner S, Pardo C, Netesan S, McArthur J, et al. Molecular programming of endothelin-1 in HIV-infected brain: role of Tat in up-regulation of ET-1 and its inhibition by statins. FASEB J. 2007;21:777-89 pubmed
    ..Our findings suggest that ET-1 may be critical in mediating the neuropathogenesis of HIV dementia and that statins may have therapeutic potential in these patients. ..
  50. Nair V, Gevaert O, Davidzon G, Plevritis S, West R. NF-κB protein expression associates with (18)F-FDG PET tumor uptake in non-small cell lung cancer: a radiogenomics validation study to understand tumor metabolism. Lung Cancer. 2014;83:189-96 pubmed publisher
    ..These findings recapitulate radiogenomics profiles previously reported by our group and provide a methodology for studying tumor biology using computational approaches. ..
  51. Sif S, Gilmore T. Interaction of the v-Rel oncoprotein with cellular transcription factor Sp1. J Virol. 1994;68:7131-8 pubmed
    ..Other Rel proteins, such as c-Rel, RelA, p52, and p50, were also able to form a complex with Sp1 in vitro...
  52. Demarchi F, Gutierrez M, Giacca M. Human immunodeficiency virus type 1 tat protein activates transcription factor NF-kappaB through the cellular interferon-inducible, double-stranded RNA-dependent protein kinase, PKR. J Virol. 1999;73:7080-6 pubmed
    ..Activation of NF-kappaB by Tat required integrity of the basic domain of Tat; previous studies have indicated that this domain is necessary for specific Tat-PKR interaction. ..
  53. Lim S, Garzino Demo A. The human immunodeficiency virus type 1 Tat protein up-regulates the promoter activity of the beta-chemokine monocyte chemoattractant protein 1 in the human astrocytoma cell line U-87 MG: role of SP-1, AP-1, and NF-kappaB consensus sites. J Virol. 2000;74:1632-40 pubmed
    ..We postulate that a Tat-mediated increase in SP1 binding activities augments the binding of AP1 and NF-kappaB, leading to synergistic activation of the MCP-1 promoter. ..
  54. Tando T, Ishizaka A, Watanabe H, Ito T, Iida S, Haraguchi T, et al. Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway. J Biol Chem. 2010;285:21951-60 pubmed publisher
    ..Through in vitro binding experiments, REQ was found to bind to several SWI/SNF complex subunits and also to the p52 NF-kappaB subunit through its nuclear localization signal containing the N-terminal region...
  55. Manches O, Fernandez M, Plumas J, Chaperot L, Bhardwaj N. Activation of the noncanonical NF-?B pathway by HIV controls a dendritic cell immunoregulatory phenotype. Proc Natl Acad Sci U S A. 2012;109:14122-7 pubmed publisher
    ..factor-3 to the Toll-like receptor/MyD88 complex, NF-?B-inducing kinase-dependent I?B kinase-? activation, and p52/RelB nuclear translocation...
  56. Hagemeier S, Barlow E, Kleman A, Kenney S. The Epstein-Barr virus BRRF1 protein, Na, induces lytic infection in a TRAF2- and p53-dependent manner. J Virol. 2011;85:4318-29 pubmed publisher
    ..Together these data suggest that Na plays an important role in regulating the switch between latent and lytic infection in epithelial cells and that this effect requires both the TRAF2 and p53 cellular proteins...
  57. Guo Q, Mao X, Zhang Y, Meng S, Xi Y, Ding Y, et al. Guizhi-Shaoyao-Zhimu decoction attenuates rheumatoid arthritis partially by reversing inflammation-immune system imbalance. J Transl Med. 2016;14:165 pubmed publisher
    ..1 (HDAC1) and heat shock protein 90 kDa alpha, class A member 1 (HSP90AA1)] and three known RA-related targets [NFKB2; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (IKBKB); and tumor necrosis factor-..
  58. Alexander K, Conley Y, Levine J, Cooper B, Paul S, Mastick J, et al. Cytokine Gene Polymorphisms Associated With Various Domains of Quality of Life in Women With Breast Cancer. J Pain Symptom Manage. 2018;55:334-350.e3 pubmed publisher
    ..higher body mass index, and receipt of adjuvant chemotherapy) and a number of cytokine gene polymorphisms (CXCL8, NFKB2, TNFSF, IL1B, IL13, and NFKB1) were associated with membership in the lower QOL classes...
  59. Mordmuller B, Krappmann D, Esen M, Wegener E, Scheidereit C. Lymphotoxin and lipopolysaccharide induce NF-kappaB-p52 generation by a co-translational mechanism. EMBO Rep. 2003;4:82-7 pubmed
    ..NF-kappaB-inducing kinase and IKK-alpha-dependent pathway, which stimulates the processing of NF-kappaB2/p100, has recently been suggested...
  60. Yang C, Murti A, Pfeffer L. Interferon induces NF-kappa B-inducing kinase/tumor necrosis factor receptor-associated factor-dependent NF-kappa B activation to promote cell survival. J Biol Chem. 2005;280:31530-6 pubmed
    ..tumor necrosis factor receptor-associated factor-2 (TRAF2) and results in IFNalpha/beta-induced processing of the p100/NF-kappaB2 precursor into p52. IFNalpha/beta stimulates NF-kappaB DNA binding and NF-kappaB-dependent transcription...
  61. Fusco A, Mazumder A, Wang V, Tao Z, Ware C, Ghosh G. The NF-κB subunit RelB controls p100 processing by competing with the kinases NIK and IKK1 for binding to p100. Sci Signal. 2016;9:ra96 pubmed publisher
    ..p52 and RelB is the product of noncanonical signaling in which the key event is the proteolytic processing of p100 to generate p52...
  62. Scheinman R, Beg A, Baldwin A. NF-kappa B p100 (Lyt-10) is a component of H2TF1 and can function as an I kappa B-like molecule. Mol Cell Biol. 1993;13:6089-101 pubmed
    ..We show here that NF-kappa B p100 is a component of the previously identified DNA-binding activity H2TF1. In addition, we show that p100 is localized in the cytoplasm in HeLa cells, where it is associated with c-Rel, ..
  63. Chen C, Chen Y, Tsai F, Chern S, Wang W. NFkappaB2 gene duplication is associated with fetal pyelectasis in partial trisomy 10q (10q24.1 --> qter). Prenat Diagn. 2008;28:364-5 pubmed publisher
  64. Gao C, Xu X, Li F, Gong B, Liu S, Cui Y, et al. Silencing pancreatic adenocarcinoma upregulated factor (PAUF) increases the sensitivity of pancreatic cancer cells to gemcitabine. Tumour Biol. 2016;37:7555-64 pubmed publisher
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    ..MW) IκB:NF-κB complexes that are highly stable, and the precursor IκBs (p105/IκBγ and p100/IκBδ), which form high-MW assemblies, thereby suppressing the activity of nearly half the cellular NF-κB [..
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    ..BAFFR), TNRFSF12 (TWEAK), CD19, CD81, CR2 (CD21), MS4A1 (CD20), (CD27), LRBA, CTLA4, PRKCD, PLCG2, NFKB1, NFKB2, PIK3CD, PIK3R, VAV1, RAC1, BLK, IKZF1 (IKAROS) and IRF2BP2...
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    Processing of the nf-kappab2 gene product p100 to generate p52 is a tightly regulated event, consistent with the fact that the processing product, p52, is hardly detected in most cell types, including T cells, although the precursor p100 ..
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    ..Polymorphisms in C-X-C motif chemokine ligand 8 (CXCL8), interleukin (IL13), and nuclear factor kappa beta 2 (NFKB2) were associated with severity scores for the mood-cognitive symptom cluster...
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    We report a family with a heterozygous NFKB2 mutation in which anti-cytokine autoantibodies were identified in one individual...
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    ..Rather, several Sp-1 sites adjoining the putative NF-kappaB binding site in the promoter region of NOS-3 gene are required for the induction of NOS-3 gene expression by Tat. ..
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    ..These results suggest that HIV-tat induces MMP-9 in human monocytes through activation of PTPase and NF-kappaB. ..
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    Processing of the NF-kappaB2 precursor protein p100 to generate p52 is an important step of NF-kappaB regulation. This proteolytic event is tightly regulated by sequences located at the C-terminal portion of p100...
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    ..Recurrent chimeras combining a transcription factor (NFkB2 or NCOR2) with a tyrosine kinase (ROS1 or TYK2) were also discovered in WT JAK1/STAT3 ALK(-) ALCL...
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    ..We propose that such effect of Tat could be part of the process of microglial activation known to take place in the brain of persons with neuro-AIDS. ..
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    The NF-kappaB2/p100 and bcl-3 genes are involved in chromosomal translocations described in chronic lymphocytic leukemias (CLL) and non-Hodgkin's lymphomas, and nuclear factor kappaB (NF-kappaB) protects cancer cells against apoptosis...
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    ..Congruently, silencing Monarch-1 with shRNA enhances the expression of p52-dependent chemokines.
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    ..TCR stimulation of human CD4+ T cells resulted in an increase in NF-kappaB2/p100 expression with no appreciable increase in p52, its cleavage product...
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    ..encodes a member of the canonical NF-kappaB regulatory pathway, was downregulated, and the transcription of the Nfkb2 gene, which encodes a member of the non-canonical NF-kappaB regulatory pathway, was upregulated in SKM-1/AzaC ..
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    ..We identified genes encoding two surface receptors (CXCR1 and IL17RE) and two TLR signaling mediators (CD86 and NFKB2) that are repressed by the RBL2-E2F4-HDAC1-BRM complex...