NFE2L1

Summary

Gene Symbol: NFE2L1
Description: nuclear factor, erythroid 2 like 1
Alias: LCR-F1, NRF1, TCF11, NF-E2-related factor 1, NFE2-related factor 1, TCF-11, locus control region-factor 1, nuclear factor (erythroid-derived 2)-like 1, nuclear factor, erythroid 2-like 1, nuclear factor, erythroid derived 2, like 1, transcription factor 11 (basic leucine zipper type), transcription factor HBZ17, transcription factor LCR-F1
Species: human

Top Publications

  1. pmc Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells
    Senthil K Radhakrishnan
    Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Mol Cell 38:17-28. 2010
  2. doi Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop
    Janos Steffen
    Institut für Biochemie CC2, Charite Universitatsmedizin Berlin, Oudenarder Strasse 16, 13347 Berlin, Germany
    Mol Cell 40:147-58. 2010
  3. pmc Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration
    Candy S Lee
    Department of Laboratory Medicine and Pathology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 108:8408-13. 2011
  4. pmc Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice
    J Y Chan
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
    EMBO J 17:1779-87. 1998
  5. ncbi The p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription
    Weiping Wang
    Department of Pathology, University of California, Irvine, Irvine, California 92697, USA
    J Biol Chem 282:24670-8. 2007
  6. pmc Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast
    J Y Chan
    Department of Laboratory Medicine, University of California, San Francisco 94143 0724
    Proc Natl Acad Sci U S A 90:11371-5. 1993
  7. ncbi Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function
    Weiping Wang
    Department of Laboratory Medicine and Pathology, University of California, Irvine, California 92697, USA
    J Biol Chem 281:19676-87. 2006
  8. doi A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells
    James M McKim
    CeeTox Inc, Kalamazoo, Michigan 49008, USA
    Cutan Ocul Toxicol 29:171-92. 2010
  9. ncbi R-alpha-lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes
    W Shen
    Institute for Nutritional Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Diabetologia 51:165-74. 2008
  10. ncbi The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development
    S C Farmer
    Department of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, 35294, USA
    Genes Dev 11:786-98. 1997

Research Grants

  1. GLOBIN GENE EXPRESSION DURING DEVELOPMENT
    Tim Townes; Fiscal Year: 2002
  2. NRF1 IN OXIDATIVE STRESS
    Jefferson Chan; Fiscal Year: 2003
  3. Metabolic mechanisms of antiestrogen resistance in breast cancer
    UBALDO EMILIO MARTINEZ OUTSCHOORN; Fiscal Year: 2013
  4. Pathogenesis of Oxidative Stress in Chagas Disease
    Nisha Jain Garg; Fiscal Year: 2013
  5. Nrf1 Molecular Pathway, Vitamin C Deficiency, and Spontaneous Fractures
    Subburaman Mohan; Fiscal Year: 2013
  6. SIRT1 as a regulator of health and lifespan of mammals
    David A Sinclair; Fiscal Year: 2013
  7. Redox Regulation of Lung Mitochondrial Biogenesis in Sepsis/Pneumonia
    Claude A Piantadosi; Fiscal Year: 2013
  8. REGULATION OF CYCLIN D1 EXPRESSION
    Richard G Pestell; Fiscal Year: 2010
  9. Functional Definition of MYC Acetylation
    MATTHEW THOMAS HURD; Fiscal Year: 2013
  10. Regulation of C. elegans SKN-1/Nrf activity by the unfolded protein response
    THOMAS KEITH BLACKWELL; Fiscal Year: 2013

Scientific Experts

Detail Information

Publications170 found, 100 shown here

  1. pmc Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells
    Senthil K Radhakrishnan
    Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Mol Cell 38:17-28. 2010
    ..Here, we report that nuclear factor erythroid-derived 2-related factor 1 (Nrf1), a transcription factor of the cap "n" collar basic leucine zipper family, but not the related Nrf2, is necessary ..
  2. doi Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop
    Janos Steffen
    Institut für Biochemie CC2, Charite Universitatsmedizin Berlin, Oudenarder Strasse 16, 13347 Berlin, Germany
    Mol Cell 40:147-58. 2010
    ..Here, we report the identification of the transcription factor TCF11 (long isoform of Nrf1) as a key regulator for 26S proteasome formation in human cells to compensate for reduced ..
  3. pmc Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration
    Candy S Lee
    Department of Laboratory Medicine and Pathology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 108:8408-13. 2011
    ..Nuclear factor E2-related factor 1 (Nrf1) transcription factor has been shown to regulate expression of antioxidant and cytoprotective genes...
  4. pmc Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice
    J Y Chan
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
    EMBO J 17:1779-87. 1998
    ..To determine the function of Nrf-1, targeted disruption of the Nrf-1 gene was carried out. Homozygous Nrf-1 mutant mice are anemic due to a non-cell autonomous defect in definitive erythropoiesis and die in utero...
  5. ncbi The p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription
    Weiping Wang
    Department of Pathology, University of California, Irvine, Irvine, California 92697, USA
    J Biol Chem 282:24670-8. 2007
    ..Activation through the ARE involves members of the CNC-subfamily of basic leucine zipper proteins including Nrf1 and Nrf2...
  6. pmc Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast
    J Y Chan
    Department of Laboratory Medicine, University of California, San Francisco 94143 0724
    Proc Natl Acad Sci U S A 90:11371-5. 1993
    ..activators and have used it to identify a human basic leucine-zipper transcription factor that we have designated Nrf1 for NF-E2-related factor 1...
  7. ncbi Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function
    Weiping Wang
    Department of Laboratory Medicine and Pathology, University of California, Irvine, California 92697, USA
    J Biol Chem 281:19676-87. 2006
    ..response elements involves members of the CNC (Cap 'n' Collar) family of basic leucine zipper proteins including Nrf1 and Nrf2. Nrf2 activity is regulated by Keap1-mediated compartmentalization in the cell...
  8. doi A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells
    James M McKim
    CeeTox Inc, Kalamazoo, Michigan 49008, USA
    Cutan Ocul Toxicol 29:171-92. 2010
    ..Three signaling pathways (Keap1/Nrf 2/ARE/EpRE, ARNT/AhR/XRE, and Nrf1/MTF/MRE) that are known to be activated by sensitizing agents were monitored by measuring the relative abundance of ..
  9. ncbi R-alpha-lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes
    W Shen
    Institute for Nutritional Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Diabetologia 51:165-74. 2008
    ..We examined the effect of two mitochondrial nutrients, R-alpha-lipoic acid (LA) and acetyl-L-carnitine (ALC), as well as their combined effect, on mitochondrial biogenesis in 3T3-L1 adipocytes...
  10. ncbi The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development
    S C Farmer
    Department of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, 35294, USA
    Genes Dev 11:786-98. 1997
    ..LCR-F1 and the related bZIP transcription factors NF-E2 p45 and NRF2 must compensate for each other in globin gene regulation...
  11. pmc The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation
    Yiguo Zhang
    Biomedical Research Center, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Biochem J 408:161-72. 2007
    b>Nrf1 (nuclear factor-erythroid 2 p45 subunit-related factor 1) is negatively controlled by its NTD (N-terminal domain) that lies between amino acids 1 and 124...
  12. pmc 4-Hydroxynonenal induces rat gamma-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling
    Hongqiao Zhang
    Department of Environmental Health Science, School of Public Health, University of Alabama at Birmingham, USA
    Am J Respir Cell Mol Biol 34:174-81. 2006
    ..HNE-increased nuclear content of Nrf1, Nrf2, and c-Jun in L2 cells was partially blocked by inhibition of either ERK1/2 or p38MAPK and completely blocked ..
  13. doi Identification of topological determinants in the N-terminal domain of transcription factor Nrf1 that control its orientation in the endoplasmic reticulum membrane
    Yiguo Zhang
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Biochem J 430:497-510. 2010
    b>Nrf1 [NF-E2 (nuclear factor-erythroid 2)-related factor 1] is a CNC (cap'n'collar) bZIP (basic-region leucine zipper) transcription factor that is tethered to ER (endoplasmic reticulum) and nuclear envelope membranes through its N-..
  14. pmc Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1
    Heping Yang
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, Keck School of Medicine USC, Los Angeles, California 90033, USA
    Mol Cell Biol 25:5933-46. 2005
    Glutamate-cysteine ligase catalytic subunit (GCLC) is regulated transcriptionally by Nrf1 and Nrf2. tert-Butylhydroquinone (TBH) induces human GCLC via Nrf2-mediated trans activation of the antioxidant-responsive element (ARE)...
  15. pmc Alpha-melanocyte-stimulating hormone counteracts the suppressive effect of UVB on Nrf2 and Nrf-dependent gene expression in human skin
    Agatha Kokot
    Department of Dermatology, Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Von Esmarch Strasse 58, 48149 Munster, Germany
    Endocrinology 150:3197-206. 2009
    ..Here, we investigated the expression and regulation of Nrf1-3, transcription factors crucially involved in protection against oxidative stress in human skin cells in vitro, ex ..
  16. ncbi A new activating role for CO in cardiac mitochondrial biogenesis
    Hagit B Suliman
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Sci 120:299-308. 2007
    ..Mitochondrial biogenesis is activated by gene and protein expression of the nuclear respiratory factor 1 (NRF1) and NRF2, of peroxisome proliferator-activated receptor gamma co-activator-1alpha, and of mitochondrial ..
  17. ncbi Expression of transcription factors during megakaryocytic differentiation of CD34+ cells from human cord blood induced by thrombopoietin
    K Terui
    Department of Pediatrics, Hirosaki University School of Medicine, Japan
    Tohoku J Exp Med 192:259-73. 2000
    ..GATA-1 and GATA-2, a GATA-binding factor, EVI-1, the large subunit of NF-E2 factor, p45 and the related factors, Nrf1, Nrf2, Nrf3, BACH1, BACH2, and the small subunit of NF-E2, MAFK and MAFG has been examined in human megakaryocytic ..
  18. ncbi hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2
    M G Marini
    Istituto di Clinica e Biologia dell Età Evolutiva, Universita di Cagliari, Cagliari 09121, Italy
    J Biol Chem 272:16490-7. 1997
    ..addition to homodimers, hMAF can also form high affinity heterodimers with two members of the NFE2/CNC-bZip family (Nrf1 and Nrf2) but not with a third family member, p45-NFE2...
  19. ncbi In vivo, nucleoside reverse-transcriptase inhibitors alter expression of both mitochondrial and lipid metabolism genes in the absence of depletion of mitochondrial DNA
    Patrick W G Mallon
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, NSW 2010, Australia
    J Infect Dis 191:1686-96. 2005
    ..The effects of this mitochondrial dysfunction on lipid metabolism, at a molecular level in vivo, have not been described...
  20. pmc NOS isoform-specific regulation of basal but not exercise-induced mitochondrial biogenesis in mouse skeletal muscle
    G D Wadley
    Department of Physiology, University of Melbourne, Parkville, Victoria, 3010, Australia
    J Physiol 585:253-62. 2007
    ..The basal mitochondrial biogenesis markers NRF1, NRF2alpha and mtTFA mRNA were significantly (P< 0...
  21. pmc Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia
    Zhenrong Xu
    Department of Pathology, University of California, D440 Medical Sciences, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 102:4120-5. 2005
    Knockout studies have shown that the transcription factor Nrf1 is essential for embryonic development...
  22. ncbi Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein
    J Y Chan
    Department of Laboratory Medicine, University of California San Francisco, 533 Parnassus Ave Room U442, San Francisco, CA 94143 0793, USA
    Biochim Biophys Acta 1517:19-26. 2000
    ..b>Nrf1 and Nrf2, two widely expressed CNC-bZIP factors, have been implicated in the regulation of genes involved in ..
  23. doi Interferon-stimulated gene ISG12b1 inhibits adipogenic differentiation and mitochondrial biogenesis in 3T3-L1 cells
    Bing Li
    Department of Animal Sciences, The Ohio State University, Columbus, Ohio 43210, USA
    Endocrinology 150:1217-24. 2009
    ..DNA content and gene expression of mitochondrial transcription factor A (mtTFA), nuclear respiratory factor 1 (NRF1), and cytochrome oxidase II, suggesting an inhibitory role of ISG12b1 in mitochondrial biogenesis and function...
  24. pmc Regionalized pathology correlates with augmentation of mtDNA copy numbers in a patient with myoclonic epilepsy with ragged-red fibers (MERRF-syndrome)
    Anja Brinckmann
    Department of Neuropediatrics, Charite University Medical School, Berlin, Germany
    PLoS ONE 5:e13513. 2010
    ..we further determined the quantity of mitochondrial proteins (COX subunits II and IV), transcription factors (NRF1 and TFAM), and VDAC1 (Porin) as a marker for the mitochondrial mass...
  25. pmc Distinct Nrf1/2-independent mechanisms mediate As 3+-induced glutamate-cysteine ligase subunit gene expression in murine hepatocytes
    James A Thompson
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Free Radic Biol Med 46:1614-25. 2009
    ..of Gclc and Gclm was also differentially regulated by the MAPK signaling pathways and occurred independent of the Nrf1/2 transcription factors...
  26. ncbi Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation
    M Giuseppina Marini
    Istituto di Neurogenetica e Neurofarmacologia, CNR, Cagliari 09121, Italy
    Blood Cells Mol Dis 29:145-58. 2002
    ..MafF can form both homodimers and high affinity heterodimers with Nrf1, Nrf2 and Nf-E2, three members of the CNC-bZip family...
  27. ncbi Isolation of a bi-directional promoter directing expression of the mouse GABPalpha and ATP synthase coupling factor 6 genes
    Y Chinenov
    Department of Biochemistry, University of Missouri at Columbia, MO, Columbia 65212, USA
    Gene 261:311-20. 2000
    ..cDNA sequence including sites for GABP (-86, -104, -169, -257, and -994), YY1 (-57), Sp1 (-242 and -226), and NRF1 (-5). No 'TATA' motif was identified near either the GABPalpha or ATPsynCF6 transcription start sites...
  28. ncbi Thioredoxin1 upregulates mitochondrial proteins related to oxidative phosphorylation and TCA cycle in the heart
    Tetsuro Ago
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, UMDNJ, New Jersey Medical School, Newark, 07103, USA
    Antioxid Redox Signal 8:1635-50. 2006
    ..analysis showed that upregulated genes frequently contained binding sites for nuclear respiratory factor 1 (NRF1)...
  29. doi Nrf3-deficient mice are not protected against acute lung and adipose tissue damages induced by butylated hydroxytoluene
    Gregory Chevillard
    Lady Davis Institute for Medical Research, Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
    FEBS Lett 584:923-8. 2010
    ..In the lung, transcript levels of the transcription factors Nrf1, Nrf2 and Nrf3 were differentially regulated by BHT treatment...
  30. pmc Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis
    Josep A Villena
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:1418-23. 2007
    ..important for mitochondrial function, parallel to other factors controlling mitochondrial gene expression, such as NRF1 and NRF2/GABPA...
  31. pmc Nrf1 is critical for redox balance and survival of liver cells during development
    Linyun Chen
    Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    Mol Cell Biol 23:4673-86. 2003
    The Nrf1 transcription factor belongs to the CNC subfamily of basic leucine zipper proteins. Knockout of Nrf1 is lethal in mouse embryos, but nothing is known about the cell types that absolutely require its function during development...
  32. pmc Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes
    Makiko Ohtsuji
    Graduate School of Comprehensive Human Sciences, Japan Science and Technology Corp, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
    J Biol Chem 283:33554-62. 2008
    b>Nrf1 is a member of the vertebrate Cap'n'Collar (CNC) transcription factor family that commonly contains a unique basic-leucine zipper domain...
  33. doi Prolonged Nrf1 overexpression triggers adipocyte inflammation and insulin resistance
    Florence H van Tienen
    Department of Genetics and Cell Biology, Maastricht University, Maastricht, The Netherlands
    J Cell Biochem 111:1575-85. 2010
    ..Although Pgc1α is regarded as the main regulator of mitochondrial function, downstream Nrf1 is the key regulator of mitochondrial biogenesis...
  34. ncbi Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress
    Laura Leung
    Department of Pathology, University of California, Irvine, Irvine, California 92697, USA
    J Biol Chem 278:48021-9. 2003
    b>Nrf1 and Nrf2 are members of the CNC family of bZIP transcription factors that exhibit structural similarities, and they are co-expressed in a wide range of tissues during development...
  35. doi Targeted disruption of nuclear factor erythroid-derived 2-like 1 in osteoblasts reduces bone size and bone formation in mice
    Jonghyun Kim
    Musculoskeletal Disease Center, Jerry L Pettis VA Medical Center, Loma Linda University, Loma Linda, CA 92357, USA
    Physiol Genomics 40:100-10. 2010
    Previous in vitro studies found that nuclear factor erythroid-derived 2-like 1 (NFE2L1) was involved in mediating ascorbic acid-induced osterix expression and osteoblast differentiation via binding to the antioxidant response element of ..
  36. pmc MCRS2 represses the transactivation activities of Nrf1
    Jia Long Wu
    IBMS, Academia Sinica, Taipei 11529, Taiwan, ROC
    BMC Cell Biol 10:9. 2009
    b>Nrf1 [p45 nuclear factor-erythroid 2 (p45 NF-E2)-related factor 1], a member of the CNC-bZIP (CNC basic region leucine zipper) family, is known to be a transcriptional activator by dimerization with distinct partners, such as Maf, FosB, c-..
  37. ncbi Coding sequence, chromosomal localization, and expression pattern of Nrf1: the mouse homolog of Drosophila erect wing
    L Schaefer
    Myogenesis Research Laboratory, Massachusetts General Hospital, Charlestown 02129, USA
    Mamm Genome 11:104-10. 2000
    ..The mouse ewg homolog, termed Nrf1, was mapped to proximal Chr 6...
  38. pmc Nuclear respiratory factor 1 controls myocyte enhancer factor 2A transcription to provide a mechanism for coordinate expression of respiratory chain subunits
    Bindu Ramachandran
    Diabetes Research Laboratory, Department of Medicine, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Biol Chem 283:11935-46. 2008
    Nuclear respiratory factors NRF1 and NRF2 regulate the expression of nuclear genes encoding heme biosynthetic enzymes, proteins required for mitochondrial genome transcription and protein import, and numerous respiratory chain subunits...
  39. pmc Role of Nrf1 in antioxidant response element-mediated gene expression and beyond
    Madhurima Biswas
    Department of Pathology and Laboratory Medicine, University of California, Irvine, D440 Medical Sciences 1, Irvine, CA 92697, USA
    Toxicol Appl Pharmacol 244:16-20. 2010
    ..Members of the Cap-N-Collar family of transcription factors, including Nrf1 and Nrf2, that bind ARE have been identified...
  40. doi Improvement of mitochondrial function in muscle of genetically obese rats after chronic supplementation with proanthocyanidins
    David Pajuelo
    Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Tarragona, Spain
    J Agric Food Chem 59:8491-8. 2011
    ..administration decreased citrate synthase activity, the amount of oxidative phosphorylation complexes I and II, and Nrf1 gene expression, without any effects on the mitochondrial oxidative capacity...
  41. pmc Increase of mitochondrial DNA content and transcripts in early bovine embryogenesis associated with upregulation of mtTFA and NRF1 transcription factors
    Pascale May-Panloup
    Biologie de la Reproduction, Labo FIV, Centre Hospitalier Universitaire d Angers, 4 rue Larrey, F 49033 Angers, France
    Reprod Biol Endocrinol 3:65. 2005
    ..However, the expression of the factors controlling mitochondrial biogenesis in early embryogenesis has received little attention so far...
  42. ncbi Pattern discovery of multivariate phenotypes by association rule mining and its scheme for genome-wide association studies
    Sung Hee Park
    Department of Bioinformatics and Life Sciences, Soongsil University, Seoul 156 743, South Korea
    Int J Data Min Bioinform 6:505-20. 2012
    ..We identified 13 SNPs for four genes (CSMD1, NFE2L1, CBX1, and SKAP1) associated with a new multivariate phenotype defined as low levels of low density lipoprotein ..
  43. pmc Transcriptional co-expression and co-regulation of genes coding for components of the oxidative phosphorylation system
    Corina Van Waveren
    Department of Cell Biology and Anatomy, University of Miami Miller School of Medicine, Miami, FL, USA
    BMC Genomics 9:18. 2008
    ....
  44. pmc Co-regulation of nuclear respiratory factor-1 by NFkappaB and CREB links LPS-induced inflammation to mitochondrial biogenesis
    Hagir B Suliman
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Sci 123:2565-75. 2010
    The nuclear respiratory factor-1 (NRF1) gene is activated by lipopolysaccharide (LPS), which might reflect TLR4-mediated mitigation of cellular inflammatory damage via initiation of mitochondrial biogenesis...
  45. pmc Sphingosine 1-phosphate (S1P) promotes mitochondrial biogenesis in Hep G2 cells by activating Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α)
    Zhixin Shen
    Clinical Hospital of Weifang Medical University, Weifang, China
    Cell Stress Chaperones 19:541-8. 2014
    ..a master regulator of mitochondrial biogenesis, as well as its downstream targets: nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (TFAM)...
  46. pmc Mitochondrial biogenesis contributes to ischemic neuroprotection afforded by LPS pre-conditioning
    R Anne Stetler
    State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Shanghai, China
    J Neurochem 123:125-37. 2012
    ..of critical components of the mitochondrial transcriptional machinery, including nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (TFAM), as well as mtDNA copy number, mitochondrial protein levels, and ..
  47. doi Positive effect of curcumin on inflammation and mitochondrial dysfunction in obese mice with liver steatosis
    Jong Jen Kuo
    Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan, R O C
    Int J Mol Med 30:673-9. 2012
    ..biogenesis genes decreased in the obese mice, including mitochondrial DNA (mtDNA), nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (Tfam), which are responsible for the lower mitochondrial respiratory ..
  48. doi PPARgamma stimulation promotes mitochondrial biogenesis and prevents glucose deprivation-induced neuronal cell loss
    Gianluca Miglio
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Italy
    Neurochem Int 55:496-504. 2009
    ..biogenesis of functional mitochondria, as indicated by the up-regulation of PPARgamma coactivator (PGC)-1alpha, NRF1, TFAM, cytochrome c oxidase subunit (CO) I and CO IV, and the increased level of mtDNA, while did not significantly ..
  49. ncbi Differential expression of Fmr-1 mRNA and FMRP in female mice brain during aging
    Kanchan Singh
    Biochemistry and Molecular Biology Laboratory, CAS in Zoology, Banaras Hindu University, Varanasi, 221005, India
    Mol Biol Rep 35:677-84. 2008
    ..increases during aging having significantly highest intensity in old age mouse whereas the intensity of alpha-Pal/Nrf1- GC-Box complex gradually decreases as a function of age...
  50. pmc The casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expression
    Yoshiki Tsuchiya
    Laboratory for Genetic Code, Graduate School of Life and Medical Sciences, Doshisha University, Kyotanabe, Japan
    Mol Cell Biol 33:3461-72. 2013
    ..Here we show that the protein kinase casein kinase 2 (CK2) regulates the transcriptional activity of Nrf1 to control the expression of the proteasome genes and thus the clearance of ubiquitinated proteins...
  51. pmc Inhibition of APE1/Ref-1 redox activity rescues human retinal pigment epithelial cells from oxidative stress and reduces choroidal neovascularization
    Y Li
    Department of Ophthalmology, Henry Ford Health System, 1 Ford Place 5D, Detroit, MI, United States Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi an, Shanxi, People s Republic of China
    Redox Biol 2:485-94. 2014
    ..responsive transcription factors that were significantly upregulated by oxLDL was restored by E3330, including Nrf2/Nrf1, p53, NF-κB, HIF1, CBF/NF-Y/YY1, and MTF-1...
  52. pmc Astragalus polysaccharide suppresses palmitate-induced apoptosis in human cardiac myocytes: the role of Nrf1 and antioxidant response
    Ji Zhang
    Department of Cardiology, Shanghai Tenth People s Hospital of Tongji University Shanghai 200072, China
    Int J Clin Exp Pathol 8:2515-24. 2015
    ..However, the mechanism by which APS mediate this effect is unclear. In the present study, the effects of APS, which suppressed ROS-mediated apoptosis through Nrf1 accumulation in human cardiac myocytes (HCMs), was investigated.
  53. doi Rosiglitazone promotes neurite outgrowth and mitochondrial function in N2A cells via PPARgamma pathway
    Ming Chang Chiang
    Department of Life Science, Fu Jen Catholic University, New Taipei City 242, Taiwan Electronic address
    Mitochondrion 14:7-17. 2014
    ..1α (PGC1α), as well as the mRNA level its downstream genes, including nuclear respiratory factors 1 and 2 (NRF1 and NRF2) and mitochondrial transcription factor A (Tfam) were induced by Rosi treatments...
  54. doi PGC-related gene variants and elite endurance athletic status in a Chinese cohort: a functional study
    Z H He
    Biology Centre, China Institute of Sport Science, Beijing, China
    Scand J Med Sci Sports 25:184-95. 2015
    ..Genotype distributions of 133 SNPs in PPARGC1A, PPARGC1B, PPRC1, TFAM, TFB1M, TFB2M, NRF1, GABPA, GABPB1, ERRα, and SIRT1 genes were compared between 235 elite Chinese (Han) endurance runners (127 women) ..
  55. ncbi Comprehensive bioinformation analysis of the mRNA profile of fascin knockdown in esophageal squamous cell carcinoma
    Bing Li Wu
    Department of Biochemistry and Molecular Biology, Shantou University Medical College, Guangzhou, China E mail
    Asian Pac J Cancer Prev 14:7221-7. 2013
    ..Previously we conducted a microarray experiment to analyze fascin knockdown by RNAi in ESCC...
  56. pmc Comparison of mitochondrial-related transcriptional levels of TFAM, NRF1 and MT-CO1 genes in single human oocytes at various stages of the oocyte maturation
    Marefat Ghaffari Novin
    Dept of Biology and Anatomical Sciences, Shahid Beheshti University of Medical Sciences, Velenjak, Tehran, Iran
    Iran Biomed J 19:23-8. 2015
    ..aim of the current study was to assess the mRNA levels of two mitochondria-related genes, including nuclear-encoded NRF1 (nuclear respiratory factor 1), mitochondrial transcription factor A (TFAM), and mitochondrial-encoded cytochrome c ..
  57. pmc Icariin induces synoviolin expression through NFE2L1 to protect neurons from ER stress-induced apoptosis
    Fei Li
    Department of Pharmacology and the Key Laboratory of Basic Pharmacology of Guizhou Province, Zunyi Medical College, Zunyi, China Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 303 E Chicago Ave, Chicago, IL, 60611, United States of America
    PLoS ONE 10:e0119955. 2015
    ..The nuclear factor erythroid 2-related factor 1 (NFE2L1) is responsible for Icariin-mediated Synoviolin gene expression...
  58. pmc mTORC1 signaling activates NRF1 to increase cellular proteasome levels
    Yinan Zhang
    a Department of Genetics and Complex Diseases Harvard T H Chan School of Public Health Boston, MA, USA
    Cell Cycle 14:2011-7. 2015
    ..element binding protein 1 (SREBP1) and nuclear factor erythroid-derived 2-related factor 1 (NRF1; also known as NFE2L1) transcription factors leading to an increase in cellular proteasome content...
  59. pmc Transcription factor Nrf1 is topologically repartitioned across membranes to enable target gene transactivation through its acidic glucose-responsive domains
    Yiguo Zhang
    The NSFC funded Laboratory of Cell Biochemistry and Gene Regulation, College of Medical Bioengineering and Faculty of Life Sciences, Chongqing University, Chongqing, China Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Scotland, United Kingdom
    PLoS ONE 9:e93458. 2014
    The membrane-bound Nrf1 transcription factor regulates critical homeostatic and developmental genes...
  60. doi Genetic loci that regulate ectopic calcification in response to knee trauma in LG/J by SM/J advanced intercross mice
    Muhammad Farooq Rai
    Department of Orthopaedic Surgery, Musculoskeletal Research Center, Washington University School of Medicine at Barnes Jewish Hospital, 425 S Euclid Avenue MS 8233, St Louis, Missouri, 63110
    J Orthop Res 33:1412-23. 2015
    ..relevant to angiogenesis (Myo1e, Kif26b, Nprl3, Stab2, Fam105b), bone metabolism/calcification (Tle3, Tgfb2, Lipc, Nfe2l1, Ank, Fam105b), arthritis (Stab2, Tbx21, Map4k4, Hoxb9, Larp6, Col1a2, Adam10, Timp3, Nfe2l1, Trpm3), and ..
  61. ncbi Expression of the Avirulence gene Avr9 of the fungal tomato pathogen Cladosporium fulvum is regulated by the global nitrogen response factor NRF1
    A Perez-Garcia
    Laboratory of Phytopathology, Wageningen University, The Netherlands
    Mol Plant Microbe Interact 14:316-25. 2001
    Here we describe the role of the Cladosporium fulvum nitrogen response factor 1 (Nrf1) gene in regulation of the expression of avirulence gene Avr9 and virulence on tomato...
  62. pmc Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis
    Wen Liu
    Authors Affiliations Department of Cancer Biology The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, Kansas and Department of Pathology, University of Alabama Birmingham, Birmingham, Alabama
    Cancer Res 74:954-63. 2014
    ..and β-oxidation) are differentially regulated by KISS1, apparently reliant upon direct KISS1 interaction with NRF1, a major transcription factor involved in mitochondrial biogenesis...
  63. ncbi Cloning and mapping of murine Nfe2l1
    J McKie
    Molecular Medicine Unit, Institute of Child Health, London, United Kingdom
    Genomics 25:716-9. 1995
    The murine homologue of the human NFE2L1 basic leucine-zipper gene was isolated from an early embryo library. The deduced amino acid sequence shows 97% identity between the two proteins...
  64. doi Redox regulation by Pitx2 and Pitx3 is critical for fetal myogenesis
    Aurore L'honoré
    Department of Developmental and Stem Cell Biology, CNRS URA 2578, 28 rue du Dr Roux, 75015 Paris, France Electronic address
    Dev Cell 29:392-405. 2014
    ..This is a consequence of downregulation of Nrf1 and genes for antioxidant enzymes, direct targets of Pitx2/3, leading to decreased expression of antioxidant ..
  65. pmc Kidney-Specific Reduction of Oxidative Phosphorylation Genes Derived from Spontaneously Hypertensive Rat
    Jason A Collett
    Department of Biology, University of Kentucky, Lexington, KY, The United States of America
    PLoS ONE 10:e0136441. 2015
    ..Kidney cortex but not liver mRNA expression of the nuclear transcription factors Tfam, NRF1, NRF2 and Pgc1α were also decreased in HT BN/SHR-mtSHR...
  66. pmc Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes
    Tadayuki Tsujita
    Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Mol Cell Biol 34:3800-16. 2014
    Liver-specific Nrf1 (NF-E2-p45-related factor 1) knockout mice develop nonalcoholic steatohepatitis...
  67. pmc Dietary restriction involves NAD⁺ -dependent mechanisms and a shift toward oxidative metabolism
    Natalie Moroz
    Department of Genetics and Complex Diseases, Division of Biological Sciences, Harvard School of Public Health, Boston, MA, USA Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Genetics, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA, USA
    Aging Cell 13:1075-85. 2014
    ..stress responses and mTOR signaling, and have been implicated in DR by some other regimens [DAF-16 (FOXO), SKN-1 (Nrf1/2/3), PHA-4 (FOXA), AAK-2 (AMPK)]. Complete DR lifespan extension required the sirtuin SIR-2...
  68. doi Regulation and function of the NFE2 transcription factor in hematopoietic and non-hematopoietic cells
    Jadwiga J Gasiorek
    Lady Davis Institute for Medical Research, McGill University, 3755 chemin de la Cote Sainte Catherine, Montreal, QC, H3T 1E2, Canada
    Cell Mol Life Sci 72:2323-35. 2015
    ..In contrast to other CNC transcription family members including NFE2L1 (NRF1), NFE2L2 (NRF2) and NFE2L3 (NRF3), which are widely expressed, earlier studies had suggested that the major ..
  69. doi Transcription factor Nrf1 is negatively regulated by its O-GlcNAcylation status
    Jiayu Chen
    Laboratory of Cell Biochemistry and Gene Regulation, College of Medical Bioengineering and Faculty of Life Sciences, University of Chongqing, No 174 Shazheng Street, Shapingba District, Chongqing 400044, China Department of Biochemistry and Molecular Biology, Zunyi Medical College, Zunyi 563000, China State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi an 710032, China
    FEBS Lett 589:2347-58. 2015
    ..The putative O-GlcNAcylation negatively regulates Nrf1/TCF11 to reduce both its protein stability and transactivation activity of target gene expression...
  70. doi Extensive temporal transcriptome and microRNA analyses identify molecular mechanisms underlying mitochondrial dysfunction induced by multi-walled carbon nanotubes in human lung cells
    Penny Nymark
    Department of Toxicogenomics, Maastricht University, Maastricht, The Netherlands
    Nanotoxicology 9:624-35. 2015
    ..was found to be regulated by two transcription factors strongly involved in mitochondrial homeostasis, APP and NRF1. In addition, four miRNAs were correlated with MMP↓ and one of them, miR-1275, was found to negatively correlate ..
  71. pmc Abnormal mitochondrial function and impaired granulosa cell differentiation in androgen receptor knockout mice
    Ruey Sheng Wang
    Graduate Institute of Clinical Medicine and Department of Obstetrics and Gynecology, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
    Int J Mol Sci 16:9831-49. 2015
    ..receptor γ (PPARγ) co-activator 1-β (PGC1-β) and its sequential downstream genes, nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (TFAM), in controlling mitochondrial biogenesis...
  72. pmc Oncogene PKCε controls INrf2-Nrf2 interaction in normal and cancer cells through phosphorylation of INrf2
    Suryakant K Niture
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA
    J Cell Sci 126:5657-69. 2013
    ..In conclusion, phosphorylation of INrf2 by PKCε leads to regulation of Nrf2, with significant implications for the survival of cancer cells, which often express lower levels of PKCε...
  73. doi Identification of transcription regulatory relationships in rheumatoid arthritis and osteoarthritis
    Guofeng Li
    Department of Traumatology, East Hospital, Tongji University School of Medicine, Number 150 Jimo Road, Pudong New District, Shanghai 200120, China
    Clin Rheumatol 32:609-15. 2013
    ..After regulatory network construction and regulatory impact factor analysis, we found that EGR1, NFE2L1, and NFYA were crucial TFs in the regulatory network of RA and NFYA, CBFB, CREB1, YY1 and PATZ1 were crucial TFs ..
  74. doi Induction of Herpud1 expression by ER stress is regulated by Nrf1
    Daniel V Ho
    Department of Laboratory Medicine and Pathology, University of California, Irvine, D440 Medical Sciences, Irvine, CA 92697, USA
    FEBS Lett 589:615-20. 2015
    ..The Nrf1 transcription factor is important in cellular stress pathways...
  75. doi Nebivolol stimulates mitochondrial biogenesis in 3T3-L1 adipocytes
    Chenglin Huang
    State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Vascular Biology, Department of Hypertension, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, PR China
    Biochem Biophys Res Commun 438:211-7. 2013
    ..PGC-1α), Sirtuin 3 (Sirt3), mitochondrial transcription factor A (Tfam) and nuclear related factor 1 (Nrf1)...
  76. pmc The role of Nrf1 and Nrf2 in the regulation of copper-responsive transcription
    Min Ok Song
    Department of Biology, College of Natural Sciences, Gangneung Wonju National University, Gangwon do 210 702, Republic of Korea Electronic address
    Exp Cell Res 322:39-50. 2014
    Recent evidences indicated Nrf2 is more potent than Nrf1 in the activation of antioxidant genes. However, the roles of Nrf proteins in the regulation of copper-responsive transcription have not been well addressed...
  77. ncbi Negative regulation of inducible nitric-oxide synthase expression mediated through transforming growth factor-beta-dependent modulation of transcription factor TCF11
    David T Berg
    Division of Biotechnology Discovery Research, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285 0444, USA
    J Biol Chem 282:36837-44. 2007
    ..We have identified a binding site in the iNOS promoter that interacts with the nuclear heterodimer TCF11/MafG using chromatin immunoprecipitation and mutation analyses...
  78. ncbi Expression profiling following local muscle inactivity in humans provides new perspective on diabetes-related genes
    James A Timmons
    Center for Genomics and Bioinformatics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Genomics 87:165-72. 2006
    ..We studied PPARGC1A (PGC-1alpha), PPARGC1B (PGC-1beta), NRF1, and a variety of mitochondrial DNA (mtDNA) and nuclear-encoded mitochondrial genes critical for oxidative ..
  79. ncbi Sequence analysis of 5'-flanking region of human pax-5 gene exon 1B
    Mao Lin Liu
    Department of Nephrology and Rheumatology, The Third Affiliated Hospital, Jiangxi Medical College, Nanchang 330008, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 10:100-3. 2002
    ..LMO(2)COM, 5 NFAT, 2 LPOLYA-B, 3 GATA1, 2 AP4, 10 MZF1, 1 ETS1-B, 1 GATA3, 1 NKX25, 2 RORA1, 1 LYF1, 2 Ikaros2, 2 TCF11, 1 GATA-C and 1 FREAC7...
  80. ncbi The Nfe2l1 gene maps to distal mouse chromosome 11
    J McKie
    Molecular Medicine Unit, Institute of Child Health, London, UK
    Mamm Genome 7:89. 1996
  81. ncbi Analysis of mutations and identification of several polymorphisms in the putative promoter region of the P34CDC2-related CDC2L1 gene located at 1P36 in melanoma cell lines and melanoma families
    Yongmei Feng
    Arizona Cancer Center, Tucson, AZ 85724, USA
    Int J Cancer 99:834-8. 2002
    ..The 4 variants were located within or beside the conserved binding sites of transcription factors TCF11, MZF1 and TAAC box, indicating their potential effects on the regulation of CDC2L1 expression...
  82. pmc NF-Y, AP2, Nrf1 and Sp1 regulate the fragile X-related gene 2 (FXR2)
    Lata Mahishi
    Gene Structure and Disease Section, NIDDK National Institute of Diabetes and Digestive and Kidney Diseases, NIH National Institutes of Health, Bethesda, MD 20892 0830, USA
    Biochem J 400:327-35. 2006
    ..versions of these factors showed that NF-YA (nuclear transcription factor Yalpha), AP2 (activator protein 2), Nrf1 (nuclear respiratory factor/alpha-Pal) and Sp1 (specificity protein 1) all bind to the FXR2 promoter both in vitro ..
  83. pmc Estradiol and tamoxifen regulate NRF-1 and mitochondrial function in mouse mammary gland and uterus
    Margarita M Ivanova
    Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, 3605 Cullen Blvd, Houston, Texas 77204, USA
    J Mol Endocrinol 51:233-46. 2013
    ..E2 increased NRF-1 protein in the uterus and MG; however, in MG, 4-OHT increased Nrf1 mRNA but not protein...
  84. pmc Low-dose radiation activates Nrf1/2 through reactive species and the Ca(2+)/ERK1/2 signaling pathway in human skin fibroblast cells
    Eun Kyeong Lee
    Research Center, Dongnam Institute of Radiological and Medical Science, Busan 619 953
    BMB Rep 46:258-63. 2013
    ..05 and 0.5 Gy X-ray irradiated normal human skin fibroblast HS27 cells. The results showed LDR induced Nrf1 and Nrf2 activation and expression of antioxidant genes HO-1, Mn-SOD, and NQO1. In particular, 0...
  85. pmc Characterization of Nrf1b, a novel isoform of the nuclear factor-erythroid-2 related transcription factor-1 that activates antioxidant response element-regulated genes
    Eric K Kwong
    Department of Laboratory Medicine and Pathology, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 7:e48404. 2012
    Nuclear factor E2-related factor 1 (Nrf1) is a basic leucine zipper transcription factor that plays an important role in the activation of cytoprotective genes through the antioxidant response elements...
  86. pmc Protective effects of peroxisome proliferator-activated receptor agonists on human podocytes: proposed mechanisms of action
    Gianluca Miglio
    Dipartimento di Scienza e Tecnologia del Farmaco, Universita degli Studi di Torino, Turin, Italy
    Br J Pharmacol 167:641-53. 2012
    ..We have investigated whether gemfibrozil, GW0742 and pioglitazone protect human podocytes against nutrient deprivation (ND)-induced cell death and the role of mitochondrial biogenesis as a cytoprotective process...
  87. pmc A proteasome inhibitor-stimulated Nrf1 protein-dependent compensatory increase in proteasome subunit gene expression reduces polycomb group protein level
    Sivaprakasam Balasubramanian
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 287:36179-89. 2012
    ..The increase in proteasome subunit level is associated with increased Nrf1 and Nrf2 level...
  88. ncbi Nrf1 is time-dependently expressed and distributed in the distinct cell types after trauma to skeletal muscles in rats
    Shu Tao Zhang
    Department of Forensic Pathology, China Medical University School of Forensic Medicine Shenyang, Liaoning, PR China
    Histol Histopathol 28:725-35. 2013
    ..the dynamic expression and distribution of the nuclear factor erythroid-derived factor 2-related factor 1 (Nrf1) by immunohistochemistry, Western blotting, and real-time PCR during wound healing of contused skeletal muscle in ..
  89. doi Training-induced alterations of skeletal muscle mitochondrial biogenesis proteins in non-insulin-dependent type 2 diabetic men
    Nana Chung
    Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Cologne, Germany
    Can J Physiol Pharmacol 90:1634-41. 2012
    ..peroxisome proliferator-activated receptor gamma coactivator-1α (PGC1α), nuclear respiratory factor-1 (NRF1), and mitochondrial transcription factor A (TFAM)) in patients suffering from non-insulin-dependent type 2 diabetes ..
  90. pmc p62 links β-adrenergic input to mitochondrial function and thermogenesis
    Timo D Müller
    Institute for Diabetes and Obesity, Helmholtz Zentrum Muenchen and Department of Medicine, Technische Universitat Munchen, Munich, Germany
    J Clin Invest 123:469-78. 2013
    ..p38 targets, affecting signaling molecules that control mitochondrial function, such as ATF2, CREB, PGC1α, DIO2, NRF1, CYTC, COX2, ATP5β, and UCP1...
  91. doi Maternal high-fat intake during pregnancy programs metabolic-syndrome-related phenotypes through liver mitochondrial DNA copy number and transcriptional activity of liver PPARGC1A
    Adriana Laura Burgueño
    Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autónoma de Buenos Aires 1427, Argentina
    J Nutr Biochem 24:6-13. 2013
    ....
  92. doi Characteristics of bovine oocytes with different meiotic competence in terms of their mitochondrial status and expression of nuclear-encoded factors
    M Machatkova
    Veterinary Research Institute, Brno, Czech Republic
    Reprod Domest Anim 47:806-14. 2012
    ..ATP) content and expression of mitochondrial transcription factor A (TFAM) and nuclear respiratory factor 1 (NRF1) were assessed before (GV) and after (MII) maturation...
  93. doi Roles of transcriptional corepressor RIP140 and coactivator PGC-1α in energy state of chronically infarcted rat hearts and mitochondrial function of cardiomyocytes
    Yanfang Chen
    Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China
    Mol Cell Endocrinol 362:11-8. 2012
    ..ERRα), peroxisome proliferate activated receptor α and β (PPARα, PPARβ), nuclear respiratory factor 1 (NRF1) and their target genes were repressed by RIP140 and induced by PGC-1α in a dose dependent manner in neonatal rat ..
  94. pmc Mitochondrial gene therapy improves respiration, biogenesis, and transcription in G11778A Leber's hereditary optic neuropathy and T8993G Leigh's syndrome cells
    Shilpa Iyer
    Center for the Study of Biological Complexity, Life Sciences, Virginia Commonwealth University, Richmond, VA 23284 3020, USA
    Hum Gene Ther 23:647-57. 2012
    ..Increased NRF1, TFAMB1, and TFAMA expression alluded to the activation of mitochondrial biogenesis as a mechanism for improving ..
  95. pmc The cytochrome c gene proximal enhancer drives activity-dependent reporter gene expression in hippocampal neurons
    Jary Y Delgado
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego CA, USA
    Front Mol Neurosci 5:31. 2012
    ..contains binding sites for both cAMP response element binding proteins (CREB) and Nuclear Respiratory Factor 1 (NRF1)...
  96. doi Investigation into developmental potential and nuclear/mitochondrial function in early wood and plains bison hybrid embryos
    R P Seaby
    Department of Biomedical Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Reprod Domest Anim 47:644-54. 2012
    ..Among the treatment groups, ATP levels and expression profiles of NRF1, TFAM, MT-CYB, BAX and BCL2 were not significantly different in both 8- to 16-cell stage and blastocyst stage ..
  97. pmc Nrf2b, novel zebrafish paralog of oxidant-responsive transcription factor NF-E2-related factor 2 (NRF2)
    Alicia R Timme-Laragy
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543, USA
    J Biol Chem 287:4609-27. 2012
    ..zebrafish (Danio rerio), an important developmental model species, possesses six nrf genes, including duplicated nrf1 and nrf2 genes. We cloned a novel zebrafish nrf2 paralog, nrf2b...
  98. pmc NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes
    Yosuke Hirotsu
    Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan
    Mol Cell Biol 32:2760-70. 2012
    ..NF-E2-related factor 1 (Nrf1) is a member of the cap'n'collar (CNC) transcription factor family...
  99. pmc Cross-regulations among NRFs and KEAP1 and effects of their silencing on arsenic-induced antioxidant response and cytotoxicity in human keratinocytes
    Rui Zhao
    School of Forensic Medicine, China Medical University, Shenyang, China
    Environ Health Perspect 120:583-9. 2012
    Nuclear factor E2-related factors (NRFs), including NRF2 and NRF1, play critical roles in mediating the cellular adaptive response to oxidative stress...
  100. doi The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle
    Zoltan Bori
    Research Institute of Sport Science, Semmelweis University, Budapest, Hungary
    Exp Gerontol 47:417-24. 2012
    ..05). Aging increased and a single exercise bout decreased the expression of nuclear respiratory factor-1 (NRF1), while the transcription factor A (TFAM) expression showed a strong relationship with VO(2max) and increased ..
  101. pmc Apolipoprotein E genotype affects tissue metallothionein levels: studies in targeted gene replacement mice
    Anne Christin Graeser
    Institute of Human Nutrition and Food Science, Christian Albrechts University Kiel, Hermann Rodewald Strasse 6, 24118, Kiel, Germany
    Genes Nutr 7:247-55. 2012
    ..The decrease in hepatic MT protein levels in APOE4 as compared to APOE3 mice was accompanied by lower nuclear Nrf1, a protein partly controlling MT gene expression...

Research Grants26

  1. GLOBIN GENE EXPRESSION DURING DEVELOPMENT
    Tim Townes; Fiscal Year: 2002
    ..The investigator has recently described a new erythroid-specific transcription factor, LCR-F1, that modulates globin gene expression. ..
  2. NRF1 IN OXIDATIVE STRESS
    Jefferson Chan; Fiscal Year: 2003
    ..Since these same pathways are affected in cancer cells, it is hoped that these studies will also contribute to a better understanding of malignancy and provide insights into novel therapeutics. ..
  3. Metabolic mechanisms of antiestrogen resistance in breast cancer
    UBALDO EMILIO MARTINEZ OUTSCHOORN; Fiscal Year: 2013
    ..with high OXPHOS metabolism via upregulation of monocarboxylate transporter 1 (MCT1), nuclear respiration factor 1 (NRF1) and mitoNEET and stromal cells with low OXPHOS metabolism and high catabolism via upregulation of monocarboxylate ..
  4. Pathogenesis of Oxidative Stress in Chagas Disease
    Nisha Jain Garg; Fiscal Year: 2013
    ..cells, and establish an environment conducive to fibrosis, (2) Test the hypothesis that PARP-1/PAR deregulates Nrf1/2 pathway and play a key role in chronic oxidative/inflammatory state of chagasic heart, and (3) Test the ..
  5. Nrf1 Molecular Pathway, Vitamin C Deficiency, and Spontaneous Fractures
    Subburaman Mohan; Fiscal Year: 2013
    ....
  6. SIRT1 as a regulator of health and lifespan of mammals
    David A Sinclair; Fiscal Year: 2013
    ..to a novel SIRT1-mediated pathway that does not involve the canonical factors PGC- 1[unreadable]/[unreadable] or NRF1/2...
  7. Redox Regulation of Lung Mitochondrial Biogenesis in Sepsis/Pneumonia
    Claude A Piantadosi; Fiscal Year: 2013
    ..Our Specific Aims are: Aim 1: Determine whether Nfe2l2 and NRF1 induction of lung mitochondrial biogenesis in murine S...
  8. REGULATION OF CYCLIN D1 EXPRESSION
    Richard G Pestell; Fiscal Year: 2010
    ..Cyclin D1 inhibits mitochondrial metabolism. Cyclin D1 phosphorylates and inactivates a transcription factor NRF1 that in turn regulates mitochondrial gene expression...
  9. Functional Definition of MYC Acetylation
    MATTHEW THOMAS HURD; Fiscal Year: 2013
    ..g. Nrf1) and in Aim 2 will be analyzed to tes the possible role of acetylation at K158 (or K149) in regulating MYC ..
  10. Regulation of C. elegans SKN-1/Nrf activity by the unfolded protein response
    THOMAS KEITH BLACKWELL; Fiscal Year: 2013
    ..elegans that the transcription factor SKN-1 (mammalian Nrf1/2/3) is also central to the UPR...
  11. Regulation of Stress Response in Neurons
    Jefferson Y Chan; Fiscal Year: 2013
    ..Members of the CNC subfamily of basic-leucine zipper transcription factors including Nrf1 and Nrf2 have been implicated to mediate ARE function...
  12. Molecular and Metabolic Pathology of CNC-bZIP Knockouts
    Jefferson Y Chan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Nrf1 and Nrf2 are members of the CNC family of bZIP transcription factors that exhibit structural similarities, and both are expressed in a wide range of tissues...
  13. Understanding and targeting Nrf1-mediated proteasome recovery pathway in cancer
    SENTHIL KUMAR RADHAKRISHNAN; Fiscal Year: 2012
    ..Preliminary studies indicated that this response was mediated by the transcription factor Nrf1 (also called Nfe2l1) and that knockdown of this factor sensitized cancer cells to proteasome inhibitor treatments...
  14. MKK3 is a Mediator of Sepsis and Lung Injury in the Elderly
    Praveen Mannam; Fiscal Year: 2013
    ..In the process, we found that MKK3 modulates key pathways associated with aging such as Nrf1, Sirt1, mitochondrial health and mitophagy...
  15. C/EBP Regulation of Dentinogenesis
    John Harrison; Fiscal Year: 2009
    ..electron microscopy, and immunohistochemical localization of endogenous C/EBP and its dimerization partner Nrf1. 2) To assess cell autonomy of the odontoblast phenotype using ex vivo dental pulp cultures and heterologous pulp ..
  16. Investigation of the Function and Regulationof Peroxiredoxins Prdx1 and Prdx6 in
    SHELLEY PHELAN; Fiscal Year: 2009
    ..lines for binding activity of candidate regulatory transcription factors (Sp1, AP1, Egr1, SRF, E2F, c-myc, p53, Nrf1 and Nrf2) and binding to putative binding sites in the Prdx1 and Prdx6 promoters...
  17. GAMMA GCS REGULATION--REGULATORY/CATALYTIC SUBUNIT GENES
    R Mulcahy; Fiscal Year: 2002
    ..dimeric transcription factors composed of small Maf proteins and various other bZIP family members, including Nrf1, Nrf2, Fos and Jun...
  18. STRUCTURE AND FUNCTION OF THE LCR-F1 GENE
    SUSAN FARMER; Fiscal Year: 1999
    ..research project is to characterize the structure and function of the gene for a transcription factor, locus control region factor 1 (LCR-F1)...
  19. Nrf1 function by conditional knockout
    Jefferson Chan; Fiscal Year: 2003
    This grant proposal is in response to PAR-98-087, and is linked to K08-DK02603, which focuses on the role of Nrf1 in oxidative stress...
  20. MOLECULAR ANALYSIS OF TRISTETRAPROLIN FUNCTION
    Thomas Blackwell; Fiscal Year: 2005
    ..abstract_text> ..
  21. MAT1A NULL MOUSE: MODEL FOR ALCOHOLIC TISSUE INJURY
    Shelly Lu; Fiscal Year: 2007
    ....
  22. REGULATION OF HEPATIC GLUTATHIONE SYNTHESIS
    Shelly Lu; Fiscal Year: 2008
    ..Our ultimate goal is to utilize this information to improve the treatment and prevent complications that may result from altered hepatic GSH synthesis. [unreadable] [unreadable]..
  23. FUNCTIONS OF A CONSERVED GERMLINE HELICASE IN C.ELEGANS
    Thomas Blackwell; Fiscal Year: 2005
    ..At the same time, they will elucidate post-transcriptional gene regulation mechanisms that may be of conserved importance during gametogenesis, and possibly for proliferation or survival of other stem cell types. ..
  24. ALTERED METHIONINE METABOLISM IN ALCOHOLIC LIVER INJURY
    Shelly Lu; Fiscal Year: 2005
    ....
  25. Gene Expression in Prediabetes: Potential Role of PGC-1
    MARY PATTI; Fiscal Year: 2006
    ..abstract_text> ..