NFE2L1

Summary

Gene Symbol: NFE2L1
Description: nuclear factor, erythroid 2-like 1
Alias: LCR-F1, NRF1, TCF11, NF-E2-related factor 1, NFE2-related factor 1, TCF-11, locus control region-factor 1, nuclear factor (erythroid-derived 2)-like 1, nuclear factor erythroid 2-related factor 1, nuclear factor, erythroid derived 2, like 1, transcription factor 11 (basic leucine zipper type), transcription factor HBZ17, transcription factor LCR-F1
Species: human

Top Publications

  1. pmc Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice
    J Y Chan
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
    EMBO J 17:1779-87. 1998
  2. pmc Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration
    Candy S Lee
    Department of Laboratory Medicine and Pathology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 108:8408-13. 2011
  3. pmc Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells
    Senthil K Radhakrishnan
    Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Mol Cell 38:17-28. 2010
  4. ncbi Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function
    Weiping Wang
    Department of Laboratory Medicine and Pathology, University of California, Irvine, California 92697, USA
    J Biol Chem 281:19676-87. 2006
  5. ncbi The p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription
    Weiping Wang
    Department of Pathology, University of California, Irvine, Irvine, California 92697, USA
    J Biol Chem 282:24670-8. 2007
  6. pmc Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast
    J Y Chan
    Department of Laboratory Medicine, University of California, San Francisco 94143 0724
    Proc Natl Acad Sci U S A 90:11371-5. 1993
  7. doi A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells
    James M McKim
    CeeTox Inc, Kalamazoo, Michigan 49008, USA
    Cutan Ocul Toxicol 29:171-92. 2010
  8. ncbi R-alpha-lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes
    W Shen
    Institute for Nutritional Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Diabetologia 51:165-74. 2008
  9. pmc The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation
    Yiguo Zhang
    Biomedical Research Center, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Biochem J 408:161-72. 2007
  10. ncbi The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development
    S C Farmer
    Department of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, 35294, USA
    Genes Dev 11:786-98. 1997

Research Grants

  1. REGULATION OF NAD(P)H--QUINONE OXIDOREDUCTASES
    ANIL JAISWAL; Fiscal Year: 2000
  2. GLOBIN GENE EXPRESSION DURING DEVELOPMENT
    Tim Townes; Fiscal Year: 2002
  3. NRF1 IN OXIDATIVE STRESS
    Jefferson Chan; Fiscal Year: 2003
  4. REGULATION OF CYCLIN D1 EXPRESSION
    Richard Pestell; Fiscal Year: 2007
  5. REGULATION OF CYCLIN D1 EXPRESSION
    Richard G Pestell; Fiscal Year: 2010
  6. Regulation of NAD(P)H: Quinone Oxidoreductases
    ANIL JAISWAL; Fiscal Year: 2005
  7. GAMMA GCS REGULATION--REGULATORY/CATALYTIC SUBUNIT GENES
    R Mulcahy; Fiscal Year: 2002
  8. Molecular and Metabolic Pathology of CNC-bZIP Knockouts
    Jefferson Y Chan; Fiscal Year: 2010
  9. Regulation of Stress Response in Neurons
    Jefferson Chan; Fiscal Year: 2009
  10. Regulation of Stress Response in Neurons
    Jefferson Y Chan; Fiscal Year: 2011

Scientific Experts

Detail Information

Publications135 found, 100 shown here

  1. pmc Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice
    J Y Chan
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
    EMBO J 17:1779-87. 1998
    ..To determine the function of Nrf-1, targeted disruption of the Nrf-1 gene was carried out. Homozygous Nrf-1 mutant mice are anemic due to a non-cell autonomous defect in definitive erythropoiesis and die in utero...
  2. pmc Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration
    Candy S Lee
    Department of Laboratory Medicine and Pathology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 108:8408-13. 2011
    ..Nuclear factor E2-related factor 1 (Nrf1) transcription factor has been shown to regulate expression of antioxidant and cytoprotective genes...
  3. pmc Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells
    Senthil K Radhakrishnan
    Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Mol Cell 38:17-28. 2010
    ..Here, we report that nuclear factor erythroid-derived 2-related factor 1 (Nrf1), a transcription factor of the cap "n" collar basic leucine zipper family, but not the related Nrf2, is necessary ..
  4. ncbi Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function
    Weiping Wang
    Department of Laboratory Medicine and Pathology, University of California, Irvine, California 92697, USA
    J Biol Chem 281:19676-87. 2006
    ..response elements involves members of the CNC (Cap 'n' Collar) family of basic leucine zipper proteins including Nrf1 and Nrf2. Nrf2 activity is regulated by Keap1-mediated compartmentalization in the cell...
  5. ncbi The p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription
    Weiping Wang
    Department of Pathology, University of California, Irvine, Irvine, California 92697, USA
    J Biol Chem 282:24670-8. 2007
    ..Activation through the ARE involves members of the CNC-subfamily of basic leucine zipper proteins including Nrf1 and Nrf2...
  6. pmc Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast
    J Y Chan
    Department of Laboratory Medicine, University of California, San Francisco 94143 0724
    Proc Natl Acad Sci U S A 90:11371-5. 1993
    ..activators and have used it to identify a human basic leucine-zipper transcription factor that we have designated Nrf1 for NF-E2-related factor 1...
  7. doi A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells
    James M McKim
    CeeTox Inc, Kalamazoo, Michigan 49008, USA
    Cutan Ocul Toxicol 29:171-92. 2010
    ..Three signaling pathways (Keap1/Nrf 2/ARE/EpRE, ARNT/AhR/XRE, and Nrf1/MTF/MRE) that are known to be activated by sensitizing agents were monitored by measuring the relative abundance of ..
  8. ncbi R-alpha-lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes
    W Shen
    Institute for Nutritional Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Diabetologia 51:165-74. 2008
    ..We examined the effect of two mitochondrial nutrients, R-alpha-lipoic acid (LA) and acetyl-L-carnitine (ALC), as well as their combined effect, on mitochondrial biogenesis in 3T3-L1 adipocytes...
  9. pmc The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation
    Yiguo Zhang
    Biomedical Research Center, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Biochem J 408:161-72. 2007
    b>Nrf1 (nuclear factor-erythroid 2 p45 subunit-related factor 1) is negatively controlled by its NTD (N-terminal domain) that lies between amino acids 1 and 124...
  10. ncbi The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development
    S C Farmer
    Department of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, 35294, USA
    Genes Dev 11:786-98. 1997
    ..LCR-F1 and the related bZIP transcription factors NF-E2 p45 and NRF2 must compensate for each other in globin gene regulation...
  11. pmc 4-Hydroxynonenal induces rat gamma-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling
    Hongqiao Zhang
    Department of Environmental Health Science, School of Public Health, University of Alabama at Birmingham, USA
    Am J Respir Cell Mol Biol 34:174-81. 2006
    ..HNE-increased nuclear content of Nrf1, Nrf2, and c-Jun in L2 cells was partially blocked by inhibition of either ERK1/2 or p38MAPK and completely blocked ..
  12. doi Identification of topological determinants in the N-terminal domain of transcription factor Nrf1 that control its orientation in the endoplasmic reticulum membrane
    Yiguo Zhang
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Biochem J 430:497-510. 2010
    b>Nrf1 [NF-E2 (nuclear factor-erythroid 2)-related factor 1] is a CNC (cap'n'collar) bZIP (basic-region leucine zipper) transcription factor that is tethered to ER (endoplasmic reticulum) and nuclear envelope membranes through its N-..
  13. pmc Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1
    Heping Yang
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, Keck School of Medicine USC, Los Angeles, California 90033, USA
    Mol Cell Biol 25:5933-46. 2005
    Glutamate-cysteine ligase catalytic subunit (GCLC) is regulated transcriptionally by Nrf1 and Nrf2. tert-Butylhydroquinone (TBH) induces human GCLC via Nrf2-mediated trans activation of the antioxidant-responsive element (ARE)...
  14. pmc Alpha-melanocyte-stimulating hormone counteracts the suppressive effect of UVB on Nrf2 and Nrf-dependent gene expression in human skin
    Agatha Kokot
    Department of Dermatology, Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Von Esmarch Strasse 58, 48149 Munster, Germany
    Endocrinology 150:3197-206. 2009
    ..Here, we investigated the expression and regulation of Nrf1-3, transcription factors crucially involved in protection against oxidative stress in human skin cells in vitro, ex ..
  15. pmc Increase of mitochondrial DNA content and transcripts in early bovine embryogenesis associated with upregulation of mtTFA and NRF1 transcription factors
    Pascale May-Panloup
    Biologie de la Reproduction, Labo FIV, Centre Hospitalier Universitaire d Angers, 4 rue Larrey, F 49033 Angers, France
    Reprod Biol Endocrinol 3:65. 2005
    ..However, the expression of the factors controlling mitochondrial biogenesis in early embryogenesis has received little attention so far...
  16. ncbi A new activating role for CO in cardiac mitochondrial biogenesis
    Hagit B Suliman
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Sci 120:299-308. 2007
    ..Mitochondrial biogenesis is activated by gene and protein expression of the nuclear respiratory factor 1 (NRF1) and NRF2, of peroxisome proliferator-activated receptor gamma co-activator-1alpha, and of mitochondrial ..
  17. ncbi Expression of transcription factors during megakaryocytic differentiation of CD34+ cells from human cord blood induced by thrombopoietin
    K Terui
    Department of Pediatrics, Hirosaki University School of Medicine, Japan
    Tohoku J Exp Med 192:259-73. 2000
    ..GATA-1 and GATA-2, a GATA-binding factor, EVI-1, the large subunit of NF-E2 factor, p45 and the related factors, Nrf1, Nrf2, Nrf3, BACH1, BACH2, and the small subunit of NF-E2, MAFK and MAFG has been examined in human megakaryocytic ..
  18. ncbi Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein
    J Y Chan
    Department of Laboratory Medicine, University of California San Francisco, 533 Parnassus Ave Room U442, San Francisco, CA 94143 0793, USA
    Biochim Biophys Acta 1517:19-26. 2000
    ..b>Nrf1 and Nrf2, two widely expressed CNC-bZIP factors, have been implicated in the regulation of genes involved in ..
  19. ncbi In vivo, nucleoside reverse-transcriptase inhibitors alter expression of both mitochondrial and lipid metabolism genes in the absence of depletion of mitochondrial DNA
    Patrick W G Mallon
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, NSW 2010, Australia
    J Infect Dis 191:1686-96. 2005
    ..The effects of this mitochondrial dysfunction on lipid metabolism, at a molecular level in vivo, have not been described...
  20. pmc Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia
    Zhenrong Xu
    Department of Pathology, University of California, D440 Medical Sciences, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 102:4120-5. 2005
    Knockout studies have shown that the transcription factor Nrf1 is essential for embryonic development...
  21. pmc NOS isoform-specific regulation of basal but not exercise-induced mitochondrial biogenesis in mouse skeletal muscle
    G D Wadley
    Department of Physiology, University of Melbourne, Parkville, Victoria, 3010, Australia
    J Physiol 585:253-62. 2007
    ..The basal mitochondrial biogenesis markers NRF1, NRF2alpha and mtTFA mRNA were significantly (P< 0...
  22. pmc Transcriptional co-expression and co-regulation of genes coding for components of the oxidative phosphorylation system
    Corina Van Waveren
    Department of Cell Biology and Anatomy, University of Miami Miller School of Medicine, Miami, FL, USA
    BMC Genomics 9:18. 2008
    ....
  23. pmc Distinct Nrf1/2-independent mechanisms mediate As 3+-induced glutamate-cysteine ligase subunit gene expression in murine hepatocytes
    James A Thompson
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Free Radic Biol Med 46:1614-25. 2009
    ..of Gclc and Gclm was also differentially regulated by the MAPK signaling pathways and occurred independent of the Nrf1/2 transcription factors...
  24. pmc Regionalized pathology correlates with augmentation of mtDNA copy numbers in a patient with myoclonic epilepsy with ragged-red fibers (MERRF-syndrome)
    Anja Brinckmann
    Department of Neuropediatrics, Charite University Medical School, Berlin, Germany
    PLoS ONE 5:e13513. 2010
    ..we further determined the quantity of mitochondrial proteins (COX subunits II and IV), transcription factors (NRF1 and TFAM), and VDAC1 (Porin) as a marker for the mitochondrial mass...
  25. ncbi hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2
    M G Marini
    Istituto di Clinica e Biologia dell Età Evolutiva, Universita di Cagliari, Cagliari 09121, Italy
    J Biol Chem 272:16490-7. 1997
    ..addition to homodimers, hMAF can also form high affinity heterodimers with two members of the NFE2/CNC-bZip family (Nrf1 and Nrf2) but not with a third family member, p45-NFE2...
  26. doi Interferon-stimulated gene ISG12b1 inhibits adipogenic differentiation and mitochondrial biogenesis in 3T3-L1 cells
    Bing Li
    Department of Animal Sciences, The Ohio State University, Columbus, Ohio 43210, USA
    Endocrinology 150:1217-24. 2009
    ..DNA content and gene expression of mitochondrial transcription factor A (mtTFA), nuclear respiratory factor 1 (NRF1), and cytochrome oxidase II, suggesting an inhibitory role of ISG12b1 in mitochondrial biogenesis and function...
  27. ncbi Thioredoxin1 upregulates mitochondrial proteins related to oxidative phosphorylation and TCA cycle in the heart
    Tetsuro Ago
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, UMDNJ, New Jersey Medical School, Newark, 07103, USA
    Antioxid Redox Signal 8:1635-50. 2006
    ..analysis showed that upregulated genes frequently contained binding sites for nuclear respiratory factor 1 (NRF1)...
  28. ncbi Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation
    M Giuseppina Marini
    Istituto di Neurogenetica e Neurofarmacologia, CNR, Cagliari 09121, Italy
    Blood Cells Mol Dis 29:145-58. 2002
    ..MafF can form both homodimers and high affinity heterodimers with Nrf1, Nrf2 and Nf-E2, three members of the CNC-bZip family...
  29. ncbi Isolation of a bi-directional promoter directing expression of the mouse GABPalpha and ATP synthase coupling factor 6 genes
    Y Chinenov
    Department of Biochemistry, University of Missouri at Columbia, MO, Columbia 65212, USA
    Gene 261:311-20. 2000
    ..cDNA sequence including sites for GABP (-86, -104, -169, -257, and -994), YY1 (-57), Sp1 (-242 and -226), and NRF1 (-5). No 'TATA' motif was identified near either the GABPalpha or ATPsynCF6 transcription start sites...
  30. pmc Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis
    Josep A Villena
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:1418-23. 2007
    ..important for mitochondrial function, parallel to other factors controlling mitochondrial gene expression, such as NRF1 and NRF2/GABPA...
  31. doi Nrf3-deficient mice are not protected against acute lung and adipose tissue damages induced by butylated hydroxytoluene
    Gregory Chevillard
    Lady Davis Institute for Medical Research, Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
    FEBS Lett 584:923-8. 2010
    ..In the lung, transcript levels of the transcription factors Nrf1, Nrf2 and Nrf3 were differentially regulated by BHT treatment...
  32. pmc Co-regulation of nuclear respiratory factor-1 by NFkappaB and CREB links LPS-induced inflammation to mitochondrial biogenesis
    Hagir B Suliman
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Sci 123:2565-75. 2010
    The nuclear respiratory factor-1 (NRF1) gene is activated by lipopolysaccharide (LPS), which might reflect TLR4-mediated mitigation of cellular inflammatory damage via initiation of mitochondrial biogenesis...
  33. ncbi Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress
    Laura Leung
    Department of Pathology, University of California, Irvine, Irvine, California 92697, USA
    J Biol Chem 278:48021-9. 2003
    b>Nrf1 and Nrf2 are members of the CNC family of bZIP transcription factors that exhibit structural similarities, and they are co-expressed in a wide range of tissues during development...
  34. pmc Nrf1 is critical for redox balance and survival of liver cells during development
    Linyun Chen
    Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    Mol Cell Biol 23:4673-86. 2003
    The Nrf1 transcription factor belongs to the CNC subfamily of basic leucine zipper proteins. Knockout of Nrf1 is lethal in mouse embryos, but nothing is known about the cell types that absolutely require its function during development...
  35. doi Prolonged Nrf1 overexpression triggers adipocyte inflammation and insulin resistance
    Florence H van Tienen
    Department of Genetics and Cell Biology, Maastricht University, Maastricht, The Netherlands
    J Cell Biochem 111:1575-85. 2010
    ..Although Pgc1α is regarded as the main regulator of mitochondrial function, downstream Nrf1 is the key regulator of mitochondrial biogenesis...
  36. pmc Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes
    Makiko Ohtsuji
    Graduate School of Comprehensive Human Sciences, Japan Science and Technology Corp, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
    J Biol Chem 283:33554-62. 2008
    b>Nrf1 is a member of the vertebrate Cap'n'Collar (CNC) transcription factor family that commonly contains a unique basic-leucine zipper domain...
  37. pmc MCRS2 represses the transactivation activities of Nrf1
    Jia Long Wu
    IBMS, Academia Sinica, Taipei 11529, Taiwan, ROC
    BMC Cell Biol 10:9. 2009
    b>Nrf1 [p45 nuclear factor-erythroid 2 (p45 NF-E2)-related factor 1], a member of the CNC-bZIP (CNC basic region leucine zipper) family, is known to be a transcriptional activator by dimerization with distinct partners, such as Maf, FosB, c-..
  38. ncbi Negative regulation of inducible nitric-oxide synthase expression mediated through transforming growth factor-beta-dependent modulation of transcription factor TCF11
    David T Berg
    Division of Biotechnology Discovery Research, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285 0444, USA
    J Biol Chem 282:36837-44. 2007
    ..We have identified a binding site in the iNOS promoter that interacts with the nuclear heterodimer TCF11/MafG using chromatin immunoprecipitation and mutation analyses...
  39. doi Targeted disruption of nuclear factor erythroid-derived 2-like 1 in osteoblasts reduces bone size and bone formation in mice
    Jonghyun Kim
    Musculoskeletal Disease Center, Jerry L Pettis VA Medical Center, Loma Linda University, Loma Linda, CA 92357, USA
    Physiol Genomics 40:100-10. 2010
    Previous in vitro studies found that nuclear factor erythroid-derived 2-like 1 (NFE2L1) was involved in mediating ascorbic acid-induced osterix expression and osteoblast differentiation via binding to the antioxidant response element of ..
  40. pmc Nuclear respiratory factor 1 controls myocyte enhancer factor 2A transcription to provide a mechanism for coordinate expression of respiratory chain subunits
    Bindu Ramachandran
    Diabetes Research Laboratory, Department of Medicine, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Biol Chem 283:11935-46. 2008
    Nuclear respiratory factors NRF1 and NRF2 regulate the expression of nuclear genes encoding heme biosynthetic enzymes, proteins required for mitochondrial genome transcription and protein import, and numerous respiratory chain subunits...
  41. ncbi Coding sequence, chromosomal localization, and expression pattern of Nrf1: the mouse homolog of Drosophila erect wing
    L Schaefer
    Myogenesis Research Laboratory, Massachusetts General Hospital, Charlestown 02129, USA
    Mamm Genome 11:104-10. 2000
    ..The mouse ewg homolog, termed Nrf1, was mapped to proximal Chr 6...
  42. ncbi Expression profiling following local muscle inactivity in humans provides new perspective on diabetes-related genes
    James A Timmons
    Center for Genomics and Bioinformatics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Genomics 87:165-72. 2006
    ..We studied PPARGC1A (PGC-1alpha), PPARGC1B (PGC-1beta), NRF1, and a variety of mitochondrial DNA (mtDNA) and nuclear-encoded mitochondrial genes critical for oxidative ..
  43. pmc NF-Y, AP2, Nrf1 and Sp1 regulate the fragile X-related gene 2 (FXR2)
    Lata Mahishi
    Gene Structure and Disease Section, NIDDK National Institute of Diabetes and Digestive and Kidney Diseases, NIH National Institutes of Health, Bethesda, MD 20892 0830, USA
    Biochem J 400:327-35. 2006
    ..versions of these factors showed that NF-YA (nuclear transcription factor Yalpha), AP2 (activator protein 2), Nrf1 (nuclear respiratory factor/alpha-Pal) and Sp1 (specificity protein 1) all bind to the FXR2 promoter both in vitro ..
  44. pmc Estradiol and tamoxifen regulate NRF-1 and mitochondrial function in mouse mammary gland and uterus
    Margarita M Ivanova
    Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, 3605 Cullen Blvd, Houston, Texas 77204, USA
    J Mol Endocrinol 51:233-46. 2013
    ..E2 increased NRF-1 protein in the uterus and MG; however, in MG, 4-OHT increased Nrf1 mRNA but not protein...
  45. ncbi Sequence analysis of 5'-flanking region of human pax-5 gene exon 1B
    Mao Lin Liu
    Department of Nephrology and Rheumatology, The Third Affiliated Hospital, Jiangxi Medical College, Nanchang 330008, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 10:100-3. 2002
    ..LMO(2)COM, 5 NFAT, 2 LPOLYA-B, 3 GATA1, 2 AP4, 10 MZF1, 1 ETS1-B, 1 GATA3, 1 NKX25, 2 RORA1, 1 LYF1, 2 Ikaros2, 2 TCF11, 1 GATA-C and 1 FREAC7...
  46. ncbi Analysis of mutations and identification of several polymorphisms in the putative promoter region of the P34CDC2-related CDC2L1 gene located at 1P36 in melanoma cell lines and melanoma families
    Yongmei Feng
    Arizona Cancer Center, Tucson, AZ 85724, USA
    Int J Cancer 99:834-8. 2002
    ..The 4 variants were located within or beside the conserved binding sites of transcription factors TCF11, MZF1 and TAAC box, indicating their potential effects on the regulation of CDC2L1 expression...
  47. ncbi The Nfe2l1 gene maps to distal mouse chromosome 11
    J McKie
    Molecular Medicine Unit, Institute of Child Health, London, UK
    Mamm Genome 7:89. 1996
  48. pmc Characterization of Nrf1b, a novel isoform of the nuclear factor-erythroid-2 related transcription factor-1 that activates antioxidant response element-regulated genes
    Eric K Kwong
    Department of Laboratory Medicine and Pathology, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 7:e48404. 2012
    Nuclear factor E2-related factor 1 (Nrf1) is a basic leucine zipper transcription factor that plays an important role in the activation of cytoprotective genes through the antioxidant response elements...
  49. pmc Protective effects of peroxisome proliferator-activated receptor agonists on human podocytes: proposed mechanisms of action
    Gianluca Miglio
    Dipartimento di Scienza e Tecnologia del Farmaco, Universita degli Studi di Torino, Turin, Italy
    Br J Pharmacol 167:641-53. 2012
    ..We have investigated whether gemfibrozil, GW0742 and pioglitazone protect human podocytes against nutrient deprivation (ND)-induced cell death and the role of mitochondrial biogenesis as a cytoprotective process...
  50. doi Maternal high-fat intake during pregnancy programs metabolic-syndrome-related phenotypes through liver mitochondrial DNA copy number and transcriptional activity of liver PPARGC1A
    Adriana Laura Burgueño
    Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autónoma de Buenos Aires 1427, Argentina
    J Nutr Biochem 24:6-13. 2013
    ....
  51. pmc A proteasome inhibitor-stimulated Nrf1 protein-dependent compensatory increase in proteasome subunit gene expression reduces polycomb group protein level
    Sivaprakasam Balasubramanian
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 287:36179-89. 2012
    ..The increase in proteasome subunit level is associated with increased Nrf1 and Nrf2 level...
  52. ncbi Nrf1 is time-dependently expressed and distributed in the distinct cell types after trauma to skeletal muscles in rats
    Shu Tao Zhang
    Department of Forensic Pathology, China Medical University School of Forensic Medicine Shenyang, Liaoning, PR China
    Histol Histopathol 28:725-35. 2013
    ..the dynamic expression and distribution of the nuclear factor erythroid-derived factor 2-related factor 1 (Nrf1) by immunohistochemistry, Western blotting, and real-time PCR during wound healing of contused skeletal muscle in ..
  53. doi Training-induced alterations of skeletal muscle mitochondrial biogenesis proteins in non-insulin-dependent type 2 diabetic men
    Nana Chung
    Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Cologne, Germany
    Can J Physiol Pharmacol 90:1634-41. 2012
    ..peroxisome proliferator-activated receptor gamma coactivator-1α (PGC1α), nuclear respiratory factor-1 (NRF1), and mitochondrial transcription factor A (TFAM)) in patients suffering from non-insulin-dependent type 2 diabetes ..
  54. pmc p62 links β-adrenergic input to mitochondrial function and thermogenesis
    Timo D Müller
    Institute for Diabetes and Obesity, Helmholtz Zentrum Muenchen and Department of Medicine, Technische Universitat Munchen, Munich, Germany
    J Clin Invest 123:469-78. 2013
    ..p38 targets, affecting signaling molecules that control mitochondrial function, such as ATF2, CREB, PGC1α, DIO2, NRF1, CYTC, COX2, ATP5β, and UCP1...
  55. ncbi Low-dose radiation activates Nrf1/2 through reactive species and the Ca(2+)/ERK1/2 signaling pathway in human skin fibroblast cells
    Eun Kyeong Lee
    Research Center, Dongnam Institute of Radiological and Medical Science, Busan 619 953
    BMB Rep 46:258-63. 2013
    ..05 and 0.5 Gy X-ray irradiated normal human skin fibroblast HS27 cells. The results showed LDR induced Nrf1 and Nrf2 activation and expression of antioxidant genes HO-1, Mn-SOD, and NQO1. In particular, 0...
  56. doi Characteristics of bovine oocytes with different meiotic competence in terms of their mitochondrial status and expression of nuclear-encoded factors
    M Machatkova
    Veterinary Research Institute, Brno, Czech Republic
    Reprod Domest Anim 47:806-14. 2012
    ..ATP) content and expression of mitochondrial transcription factor A (TFAM) and nuclear respiratory factor 1 (NRF1) were assessed before (GV) and after (MII) maturation...
  57. doi Roles of transcriptional corepressor RIP140 and coactivator PGC-1α in energy state of chronically infarcted rat hearts and mitochondrial function of cardiomyocytes
    Yanfang Chen
    Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China
    Mol Cell Endocrinol 362:11-8. 2012
    ..ERRα), peroxisome proliferate activated receptor α and β (PPARα, PPARβ), nuclear respiratory factor 1 (NRF1) and their target genes were repressed by RIP140 and induced by PGC-1α in a dose dependent manner in neonatal rat ..
  58. doi Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop
    Janos Steffen
    Institut für Biochemie CC2, Charite Universitatsmedizin Berlin, Oudenarder Strasse 16, 13347 Berlin, Germany
    Mol Cell 40:147-58. 2010
    ..Here, we report the identification of the transcription factor TCF11 (long isoform of Nrf1) as a key regulator for 26S proteasome formation in human cells to compensate for reduced ..
  59. pmc Mitochondrial gene therapy improves respiration, biogenesis, and transcription in G11778A Leber's hereditary optic neuropathy and T8993G Leigh's syndrome cells
    Shilpa Iyer
    Center for the Study of Biological Complexity, Life Sciences, Virginia Commonwealth University, Richmond, VA 23284 3020, USA
    Hum Gene Ther 23:647-57. 2012
    ..Increased NRF1, TFAMB1, and TFAMA expression alluded to the activation of mitochondrial biogenesis as a mechanism for improving ..
  60. doi Investigation into developmental potential and nuclear/mitochondrial function in early wood and plains bison hybrid embryos
    R P Seaby
    Department of Biomedical Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Reprod Domest Anim 47:644-54. 2012
    ..Among the treatment groups, ATP levels and expression profiles of NRF1, TFAM, MT-CYB, BAX and BCL2 were not significantly different in both 8- to 16-cell stage and blastocyst stage ..
  61. pmc Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism
    Adam Ertel
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 11:253-63. 2012
    ..Using data mining and bioinformatics approaches, we also provide key evidence of a role for PGC1a/NRF1 signaling in the pathogenesis of (1) two-compartment tumor metabolism, and (2) mitochondrial biogenesis in human ..
  62. pmc Nrf2b, novel zebrafish paralog of oxidant-responsive transcription factor NF-E2-related factor 2 (NRF2)
    Alicia R Timme-Laragy
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543, USA
    J Biol Chem 287:4609-27. 2012
    ..zebrafish (Danio rerio), an important developmental model species, possesses six nrf genes, including duplicated nrf1 and nrf2 genes. We cloned a novel zebrafish nrf2 paralog, nrf2b...
  63. doi Dietary restriction increases skeletal muscle mitochondrial respiration but not mitochondrial content in C57BL/6 mice
    Sarah Hempenstall
    Integrative and Environmental Physiology, Institute of Biological and Environmental Sciences, University of Aberdeen, Tillydrone Avenue, Aberdeen, UK
    Mech Ageing Dev 133:37-45. 2012
    ..total and nuclear protein levels of PGC-1α, mRNA levels of several mitochondrial associated proteins (Pgc-1α, Nrf1, Core 1, Cox IV, Atps) and cytochrome c oxidase content were increased in skeletal muscle of DR mice...
  64. pmc Apolipoprotein E genotype affects tissue metallothionein levels: studies in targeted gene replacement mice
    Anne Christin Graeser
    Institute of Human Nutrition and Food Science, Christian Albrechts University Kiel, Hermann Rodewald Strasse 6, 24118, Kiel, Germany
    Genes Nutr 7:247-55. 2012
    ..The decrease in hepatic MT protein levels in APOE4 as compared to APOE3 mice was accompanied by lower nuclear Nrf1, a protein partly controlling MT gene expression...
  65. pmc The cytochrome c gene proximal enhancer drives activity-dependent reporter gene expression in hippocampal neurons
    Jary Y Delgado
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego CA, USA
    Front Mol Neurosci 5:31. 2012
    ..contains binding sites for both cAMP response element binding proteins (CREB) and Nuclear Respiratory Factor 1 (NRF1)...
  66. pmc NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes
    Yosuke Hirotsu
    Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan
    Mol Cell Biol 32:2760-70. 2012
    ..NF-E2-related factor 1 (Nrf1) is a member of the cap'n'collar (CNC) transcription factor family...
  67. doi The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle
    Zoltan Bori
    Research Institute of Sport Science, Semmelweis University, Budapest, Hungary
    Exp Gerontol 47:417-24. 2012
    ..05). Aging increased and a single exercise bout decreased the expression of nuclear respiratory factor-1 (NRF1), while the transcription factor A (TFAM) expression showed a strong relationship with VO(2max) and increased ..
  68. pmc Cross-regulations among NRFs and KEAP1 and effects of their silencing on arsenic-induced antioxidant response and cytotoxicity in human keratinocytes
    Rui Zhao
    School of Forensic Medicine, China Medical University, Shenyang, China
    Environ Health Perspect 120:583-9. 2012
    Nuclear factor E2-related factors (NRFs), including NRF2 and NRF1, play critical roles in mediating the cellular adaptive response to oxidative stress...
  69. doi cAMP/Ca2+ response element-binding protein plays a central role in the biogenesis of respiratory chain proteins in mammalian cells
    Domenico De Rasmo
    Department of Medical Biochemistry, Biology and Physics, University of Bari, P zza G Cesare, 70124 Bari, Italy
    IUBMB Life 62:447-52. 2010
    ..a down-stream cascade of transcriptional complexes, which involve in sequence, the nuclear factors TORCs, PGC-1, NRF1 and NRF2, and the mitochondrial factor mitochondrial transcriptional factor A...
  70. doi Quercetin induces the expression of peroxiredoxins 3 and 5 via the Nrf2/NRF1 transcription pathway
    Naoya Miyamoto
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan
    Invest Ophthalmol Vis Sci 52:1055-63. 2011
    ..The purpose of this study was to investigate whether quercetin can activate transcription factors and induce the expression of the PRDX family...
  71. pmc Low-Frequency Electroacupuncture Improves Insulin Sensitivity in Obese Diabetic Mice through Activation of SIRT1/PGC-1α in Skeletal Muscle
    Fengxia Liang
    Department of Acupuncture and Moxibustion, Hubei University of Chinese Medicine, Wuhan 430061, China
    Evid Based Complement Alternat Med 2011:735297. 2011
    ..of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), nuclear respiratory factor 1 (NRF1), and acyl-CoA oxidase (ACOX)...
  72. ncbi Chromosomal localization of the human NF-E2 family of bZIP transcription factors by fluorescence in situ hybridization
    J Y Chan
    Department of Laboratory Medicine, University of California, San Francisco 94143 0724
    Hum Genet 95:265-9. 1995
    A family of human genes encoding basic-leucine zipper (bZIP) transcription factors, p45-NF-E2, Nrf1 and Nrf2, have been isolated independently...
  73. doi Estrogen-induced reactive oxygen species-mediated signalings contribute to breast cancer
    Victor Okoh
    Department of Environmental and Occupational Health, Florida International University, Miami, FL, USA
    Biochim Biophys Acta 1815:115-33. 2011
    ..g., AP-1, NRF1, E2F, NF-kB and CREB of non-genomic pathways which are responsive to both oxidants and estrogen...
  74. pmc Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis
    Hyun Seok Kim
    Genetics of Development and Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 12:224-36. 2010
    ..Here, we show that SIRT1 forms a complex with FOXO3a and NRF1 on the SIRT6 promoter and positively regulates expression of SIRT6, which, in turn, negatively regulates glycolysis,..
  75. pmc Long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytes
    Rui Zhao
    School of Forensic Medicine, China Medical University, Shenyang, China
    Environ Health Perspect 119:56-62. 2011
    ..Nuclear factor-erythroid 2-related factor 1 (NRF1, also called NFE2L1) plays a critical role in regulating the expression of many antioxidant response element (ARE)-dependent genes.
  76. pmc Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation
    Rajnish K Chaturvedi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Hum Mol Genet 19:3190-205. 2010
    ..In the striatum of the HD mice, the baseline levels of PGC-1alpha, NRF1, NRF2, Tfam, COX-II, PPARdelta, CREB and ERRalpha mRNA and mitochondrial DNA (mtDNA), were significantly reduced...
  77. pmc Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins
    K Itoh
    Department of Biochemistry, Tohoku University School of Medicine, Sendai, Japan
    Mol Cell Biol 15:4184-93. 1995
    ..zipper domain which is well conserved among members of the CNC family proteins (Cap 'n' collar, p45 NF-E2, LCR-F1, Nrf1, and Nrf2). Hence, we named this protein ECH (erythroid cell-derived protein with CNC homology)...
  78. pmc Tamoxifen increases nuclear respiratory factor 1 transcription by activating estrogen receptor beta and AP-1 recruitment to adjacent promoter binding sites
    Margarita M Ivanova
    Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    FASEB J 25:1402-16. 2011
    ..NRF-1 expression by recruiting ERβ, cJun, cFos, CBP, and RNA polymerase II to and dismissing NCoR from the NRF1 promoter...
  79. pmc KPNA6 (Importin {alpha}7)-mediated nuclear import of Keap1 represses the Nrf2-dependent antioxidant response
    Zheng Sun
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA
    Mol Cell Biol 31:1800-11. 2011
    ..The nuclear import of Keap1 requires its C-terminal Kelch domain and is independent of Nrf1 and Nrf2...
  80. ncbi Involvement of the electrophile responsive element and p53 in the activation of hepatic stellate cells as a response to electrophile menadione
    Vasilis Vasiliou
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, P O Box C238, Denver, CO 80262, USA
    Arch Biochem Biophys 413:164-71. 2003
    ..supershift analysis revealed that, although Nrf2 is a member of the EPRE-binding complex in both NFSC and CFSC, Nrf1 was identified as a part of the protein/DNA complex only in CFSC...
  81. ncbi Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex
    N Lenka
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Prog Nucleic Acid Res Mol Biol 61:309-44. 1998
    ..activity of the promoter in most of the ubiquitous genes is regulated by factors binding to the 5' upstream Sp1, NRF1, GABP (NRF2), and YY1 sites...
  82. doi The anthocyanin cyanidin-3-O-β-glucoside, a flavonoid, increases hepatic glutathione synthesis and protects hepatocytes against reactive oxygen species during hyperglycemia: Involvement of a cAMP-PKA-dependent signaling pathway
    Wei Zhu
    Department of Toxicology, Guangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong, People s Republic of China
    Free Radic Biol Med 52:314-27. 2012
    ..upregulation of glutamate-cysteine ligase catalytic subunit (Gclc) expression by C3G occurred independent of the Nrf1/2 transcription factors...
  83. pmc Mitochondrial biogenesis and the development of diabetic retinopathy
    Julia M Santos
    Kresge Eye Institute, Wayne State University, Detroit, MI 48201, USA
    Free Radic Biol Med 51:1849-60. 2011
    ..Damage of mtDNA, copy number, and biogenesis (PGC1, NRF1, TFAM) were analyzed in the retinas from streptozotocin-diabetic wild-type (WT) and MnSOD transgenic (Tg) mice...
  84. doi NOR1 is an HSF1- and NRF1-regulated putative tumor suppressor inactivated by promoter hypermethylation in nasopharyngeal carcinoma
    Wenjuan Li
    Cancer Research Institute, Xiangya School of Medicine, Central South University, Xiangya Road, Changsha, Hunan 410078, China
    Carcinogenesis 32:1305-14. 2011
    ..Frequent epigenetic inactivation of the NOR1 gene in NPC suggests that it may be a critical tumor suppressor involved in the development of NPC...
  85. doi IL-6 induces lipolysis and mitochondrial dysfunction, but does not affect insulin-mediated glucose transport in 3T3-L1 adipocytes
    Chenbo Ji
    Department of Pediatrics, Nanjing Maternal and Child Health Hospital of Nanjing Medical University, Nanjing, China
    J Bioenerg Biomembr 43:367-75. 2011
    ..However, insulin-stimulated glucose transport was unaltered. PGC-1α, NRF1, and mtTFA mRNA levels were markedly increased, and the mitochondrial contents were also increased...
  86. pmc Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity
    Xuan Li
    Joslin Diabetes Center, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1002119. 2011
    SKN-1, the Caenorhabditis elegans Nrf1/2/3 ortholog, promotes both oxidative stress resistance and longevity...
  87. doi Transcription factor binding sites and other features in human and Drosophila proximal promoters
    Charles Vinson
    Laboratory of Metabolism, NCI, NIH, Bethesda, MD, 20892, USA
    Subcell Biochem 52:205-22. 2011
    ..The TFBSs that are enriched in proximal promoters (-200 bps to the TSS) are CCAAT, ETS, NRF1, SP1, E-Box, CRE, BoxA, and TATA. Only TATA occurs in a DNA strand dependent manner...
  88. doi NARP mutation and mtDNA depletion trigger mitochondrial biogenesis which can be modulated by selenite supplementation
    Marta Wojewoda
    Laboratory of Bioenergetics and Biomembranes, Department of Biochemistry, Nencki Institute of Experimental Biology, 3 Pasteur St, 02 993 Warsaw, Poland
    Int J Biochem Cell Biol 43:1178-86. 2011
    ..Selenite supplementation increased the level of NRF1 and nuclear accumulation of NRF2, but we did not detect any major changes in the levels of investigated respiratory ..
  89. pmc Erect Wing facilitates context-dependent Wnt/Wingless signaling by recruiting the cell-specific Armadillo-TCF adaptor Earthbound to chromatin
    Nan Xin
    Department of Genetics and Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, NH 03755, USA
    Development 138:4955-67. 2011
    ..the fly homolog of the human sequence-specific DNA-binding transcriptional activator nuclear respiratory factor 1 (NRF1), in promoting contextual regulation of Wingless signaling...
  90. ncbi Regional differences in oxidative capacity of rat white adipose tissue are linked to the mitochondrial content of mature adipocytes
    Catherine Deveaud
    Institut de Biochimie et de Génétique Cellulaires, UMR 5095 CNRS Université Victor Segalen, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Mol Cell Biochem 267:157-66. 2004
    ..Moreover, NRF1 protein, which belongs to the transcriptional activator family and is thought to be involved in mitochondrial ..
  91. ncbi Effect of four genes (ALDH1, NRF1, JAM and KBL) on proliferation arrest in a non-small cell bronchopulmonary cancer line
    C Jacquot
    ISOMER Laboratory of Marine Pharmacology, Faculty of Pharmacy, Nantes, France
    Anticancer Res 22:2229-35. 2002
    ..An antisense strategy showed that amino-ketobutyrate ligase is involved in the proliferation arrest of NSCLC-N6 cells in the G1-phase after VT1 treatment...
  92. ncbi Mechanisms of HDAC inhibitor-induced thrombocytopenia
    Hideaki Matsuoka
    Pharmacology Research Laboratories, Astellas Pharma Inc, 2 1 6 Kashima, Yodogawa ku, Osaka 532 8514, Japan
    Eur J Pharmacol 571:88-96. 2007
    ..1, Fli-1, AML1, and TCF11) are transcriptionally repressed by HDAC inhibitors in a similar pattern (R>0...
  93. ncbi Structure, expression, and functional characterization of the mouse CLP-1 gene
    Facan Huang
    Department of Anatomy and Cell Biology, Center for Cardiovascular and Muscle Research, Box 5, State University of New York, Health Science Center at Brooklyn, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Gene 292:245-59. 2002
    ..CLP-1 may be a transcriptional mediator capable of interacting with and potentiating cell-specific transcription factors...
  94. ncbi Cloning and analysis of the rat glutamate-cysteine ligase modifier subunit promoter
    H Yang
    Division of Gastroenterology and Liver Diseases, USC Liver Disease Research Center, University of Southern California, Los Angeles, CA 90033, USA
    Biochem Biophys Res Commun 285:476-82. 2001
    ..binding sites for many transcription factors including activator protein 1 (AP-1), transcription factor 11 (TCF11), heat shock transcription factor (HSF), and nuclear factor kappa B (NFkappaB)...
  95. pmc Effects of hepatocyte growth factor on glutathione synthesis, growth, and apoptosis is cell density-dependent
    Heping Yang
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine USC, Los Angeles, CA 90033, USA
    Exp Cell Res 314:398-412. 2008
    ..This correlated with increased protein levels and nuclear binding activities of c-Jun, c-Fos, p65, p50, Nrf1 and Nrf2 to the promoter region of these genes...
  96. ncbi Regulation of genes encoding NAD(P)H:quinone oxidoreductases
    A K Jaiswal
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
    Free Radic Biol Med 29:254-62. 2000
    ..In addition to Nrf2 and c-Jun, other nuclear transcription factors including Nrf1, Jun-B, and Jun-D also bind to the ARE and regulate expression and induction of NQO1 gene...
  97. ncbi Genetic variation and association analyses of the nuclear respiratory factor 1 (nRF1) gene in Chinese patients with type 2 diabetes
    Yang Liu
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China
    Diabetes 57:777-82. 2008
    Nuclear respiratory factor 1 (NRF1) is a strong biological and positional candidate to contribute to type 2 diabetes susceptibility...
  98. ncbi Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators
    Bruce M Spiegelman
    Dana Farber Cancer Institute, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Novartis Found Symp 287:60-3; discussion 63-9. 2007
    ..ERRalpha, NRF1 and NRF2 are key targets of the PGC1s in mitochondrial biogenesis...
  99. ncbi Nuclear factor-E2-related factor-1 mediates ascorbic acid induction of osterix expression via interaction with antioxidant-responsive element in bone cells
    Weirong Xing
    Musculoskeletal Disease Center, Jerry L Pettis Memorial Veterans Affairs Medical Center, Loma Linda, CA 92357, USA
    J Biol Chem 282:22052-61. 2007
    ..mechanisms by which AA regulates osteoblast differentiation, we examined the effect of AA on osterix expression via Nrf1 (NF-E2-related factor-1) binding to antioxidant-responsive element (ARE) in bone marrow stromal (BMS) cells...
  100. ncbi Structural organization and mapping of the human TCF11 gene
    L Luna
    Biotechnology Centre of Oslo, University of Oslo, Blindern, Norway
    Genomics 27:237-44. 1995
    We recently cloned human cDNA representing several mRNA isoforms of human TCF11, a transcription factor of the basic-region, leucine-zipper (bZIP) family located on chromosome 17q22 as well as a genomic clone of this gene...
  101. ncbi Regulation and co-ordination of nuclear gene expression during mitochondrial biogenesis
    S Goffart
    Institute of Vegetative Physiology, University of Koln, Robert Koch Strase 39, 50931 Koln, Germany
    Exp Physiol 88:33-40. 2003
    ..Sp1 or YY1, as well as transcription factors specific for mitochondrial genes like the nuclear respiratory factors NRF1 and 2...

Research Grants63

  1. REGULATION OF NAD(P)H--QUINONE OXIDOREDUCTASES
    ANIL JAISWAL; Fiscal Year: 2000
    ..1) a 24-bp antioxidant response element (ARE) between nucleotides -470 and -447 and nuclear transcription factors Nrf1 and Nrf2, which are required both for the high level of NQO1 gene transcription in tumor cells and for induction in ..
  2. GLOBIN GENE EXPRESSION DURING DEVELOPMENT
    Tim Townes; Fiscal Year: 2002
    ..The investigator has recently described a new erythroid-specific transcription factor, LCR-F1, that modulates globin gene expression. ..
  3. NRF1 IN OXIDATIVE STRESS
    Jefferson Chan; Fiscal Year: 2003
    ..Since these same pathways are affected in cancer cells, it is hoped that these studies will also contribute to a better understanding of malignancy and provide insights into novel therapeutics. ..
  4. REGULATION OF CYCLIN D1 EXPRESSION
    Richard Pestell; Fiscal Year: 2007
    ..Cyclin D1 inhibits mitochondrial metabolism. Cyclin D1 phosphorylates and inactivates a transcription factor NRF1 that in turn regulates mitochondrial gene expression...
  5. REGULATION OF CYCLIN D1 EXPRESSION
    Richard G Pestell; Fiscal Year: 2010
    ..Cyclin D1 inhibits mitochondrial metabolism. Cyclin D1 phosphorylates and inactivates a transcription factor NRF1 that in turn regulates mitochondrial gene expression...
  6. Regulation of NAD(P)H: Quinone Oxidoreductases
    ANIL JAISWAL; Fiscal Year: 2005
    ..The nuclear factors Nrf2 and Nrf1 heterodimerize with Jun proteins and bind to the ARE...
  7. GAMMA GCS REGULATION--REGULATORY/CATALYTIC SUBUNIT GENES
    R Mulcahy; Fiscal Year: 2002
    ..dimeric transcription factors composed of small Maf proteins and various other bZIP family members, including Nrf1, Nrf2, Fos and Jun...
  8. Molecular and Metabolic Pathology of CNC-bZIP Knockouts
    Jefferson Y Chan; Fiscal Year: 2010
    b>Nrf1 and Nrf2 are members of the CNC family of bZIP transcription factors that exhibit structural similarities, and both are expressed in a wide range of tissues...
  9. Regulation of Stress Response in Neurons
    Jefferson Chan; Fiscal Year: 2009
    ..Members of the CNC subfamily of basic-leucine zipper transcription factors including Nrf1 and Nrf2 have been implicated to mediate ARE function...
  10. Regulation of Stress Response in Neurons
    Jefferson Y Chan; Fiscal Year: 2011
    ..Members of the CNC subfamily of basic-leucine zipper transcription factors including Nrf1 and Nrf2 have been implicated to mediate ARE function...
  11. Nrf1 function by conditional knockout
    Jefferson Chan; Fiscal Year: 2003
    This grant proposal is in response to PAR-98-087, and is linked to K08-DK02603, which focuses on the role of Nrf1 in oxidative stress...
  12. Molecular and Metabolic Pathology of CNC-bZIP Knockouts
    Jefferson Chan; Fiscal Year: 2006
    ..Two members of the CNC-basic-leucine zipper transcription factor family, Nrf1 and Nrf2, are expressed at high levels in various organs such as the liver, kidney and muscle...
  13. Molecular and Metabolic Pathology of CNC-bZIP Knockouts
    Jefferson Chan; Fiscal Year: 2003
    ..Two members of the CNC-basic-leucine zipper transcription factor family, Nrf1 and Nrf2, are expressed at high levels in various organs such as the liver, kidney and muscle...
  14. Delineating the Huntington's disease mechanism by manipulating the mouse HD
    Marcy MacDonald; Fiscal Year: 2007
    ..the immediate early gene response in striatum to the HD CAG repeat that causes the majority of HD cases, including Nrf1/E2F senescence target genes...
  15. Delineating the Huntington's disease mechanism by manipulating the mouse HD
    Marcy MacDonald; Fiscal Year: 2009
    ..the immediate early gene response in striatum to the HD CAG repeat that causes the majority of HD cases, including Nrf1/E2F senescence target genes...
  16. Delineating the Huntington's disease mechanism by manipulating the mouse HD
    Marcy MacDonald; Fiscal Year: 2010
    ..the immediate early gene response in striatum to the HD CAG repeat that causes the majority of HD cases, including Nrf1/E2F senescence target genes...
  17. DNA SEQUENCES IMPACT ESTROGEN AND ANTIESTROGEN ACTIVITY
    CAROLYN KLINGE; Fiscal Year: 2009
    ....
  18. REGULATION OF METHIONINE ADENOSYLTRANSFERASE IN LIVER
    SHELLY CHI LOO LU; Fiscal Year: 2010
    ..Our overall goals are to better understand regulation and function of hepatic MAT genes, and to develop novel therapies against abnormal liver growth. ..
  19. Role of MAT and SAMe in Colon Cancer Pathogenesis and Treatment
    SHELLY CHI LOO LU; Fiscal Year: 2010
    ....
  20. ALTERED METHIONINE METABOLISM IN ALCOHOLIC LIVER INJURY
    Shelly Lu; Fiscal Year: 2005
    ....
  21. Gene Expression in Prediabetes: Potential Role of PGC-1
    MARY PATTI; Fiscal Year: 2006
    ..abstract_text> ..
  22. DNA SEQUENCES IMPACT ESTROGEN AND ANTIESTROGEN ACTIVITY
    CAROLYN KLINGE; Fiscal Year: 2002
    ....
  23. Summer Endocrine Research Training Program
    CAROLYN KLINGE; Fiscal Year: 2007
    ..years the University of Louisville has increased its commitment to health science research and infrastructure, graduate education, and minority recruitment, making this short-term training program for medical students particularly timely ..