NFATC2

Summary

Gene Symbol: NFATC2
Description: nuclear factor of activated T cells 2
Alias: NFAT1, NFATP, nuclear factor of activated T-cells, cytoplasmic 2, NF-ATc2, NFAT pre-existing subunit, NFAT transcription complex, preexisting component, T cell transcription factor NFAT1, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2, nuclear factor of activated T-cells, preexisting component, preexisting nuclear factor of activated T-cells 2
Species: human
Products:     NFATC2

Top Publications

  1. Ho S, Timmerman L, Northrop J, Crabtree G. Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT. Adv Exp Med Biol. 1994;365:167-73 pubmed
    ..Now that these proteins are purified and cloned, the major goals will be to understand their role and the roles of other family members in thymic development. ..
  2. Torgerson T, Genin A, Chen C, Zhang M, Zhou B, Anover Sombke S, et al. FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression. J Immunol. 2009;183:907-15 pubmed publisher
    ..NFAT2 is typically expressed at low levels in resting T cells, but is up-regulated by NFAT1 upon cellular activation...
  3. Neri F, Giolo G, Potestà M, Petrini S, Doria M. The HIV-1 Nef protein has a dual role in T cell receptor signaling in infected CD4+ T lymphocytes. Virology. 2011;410:316-26 pubmed publisher
    ..Our data indicate that Nef has a dual role in the modulation of TCR signaling aimed at favoring HIV-1 replication and spread in both quiescent and metabolically active CD4(+) T lymphocytes. ..
  4. Crabtree G. Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT. Cell. 1999;96:611-4 pubmed
  5. Horsley V, Pavlath G. NFAT: ubiquitous regulator of cell differentiation and adaptation. J Cell Biol. 2002;156:771-4 pubmed
    ..This review addresses the recent data implicating NFAT in the control of gene expression influencing the development and adaptation of numerous mammalian cell types. ..
  6. Wu A, Ericson K, Chao W, Low W. NFAT and AP1 are essential for the expression of a glioblastoma multiforme related IL-13Ra2 transcript. Cell Oncol. 2010;32:313-29 pubmed publisher
    ..This study is the first to characterize the role of NFAT and AP1 in the regulation of IL-13Ra2 expression, and provides insight into understanding the high levels of IL-13Ra2 expressed by GBM cells. ..
  7. Yiu G, Toker A. NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2. J Biol Chem. 2006;281:12210-7 pubmed
    ..Conversely, loss of NFAT1 protein expression using small interfering RNA led to a reduction in COX-2 transcription and reduced invasion...
  8. Chen M, O Connor K. Integrin alpha6beta4 promotes expression of autotaxin/ENPP2 autocrine motility factor in breast carcinoma cells. Oncogene. 2005;24:5125-30 pubmed
    ..We determine that integrin alpha6beta4-dependent overexpression of autotaxin in MDA-MB-435 cells is mediated by NFAT1, but not NFAT5, through the use of siRNAs that specifically target autotaxin, integrin beta4, NFAT1 and NFAT5...
  9. Wilkins B, De Windt L, Bueno O, Braz J, Glascock B, Kimball T, et al. Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth. Mol Cell Biol. 2002;22:7603-13 pubmed
    ..NFATc3-null mice also demonstrated attenuated pressure overload- and angiotensin II-induced cardiac hypertrophy. These results provide genetic evidence that calcineurin-regulated responses require NFAT effectors in vivo. ..

More Information

Publications86

  1. Vázquez Cedeira M, Lazo P. Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2. J Biol Chem. 2012;287:42739-50 pubmed publisher
    ..Invasion by cancer cells has been associated with NFAT1 (nuclear factor of activated T cells) activation and expression of the COX-2 (cyclooxygenase 2) gene...
  2. Okamura H, Aramburu J, Garcia Rodriguez C, Viola J, Raghavan A, Tahiliani M, et al. Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity. Mol Cell. 2000;6:539-50 pubmed
    ..We show by mass spectrometry that NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are ..
  3. Macian F, Rao A. Reciprocal modulatory interaction between human immunodeficiency virus type 1 Tat and transcription factor NFAT1. Mol Cell Biol. 1999;19:3645-53 pubmed
    ..We have investigated the role of a host cell protein, the transcription factor NFAT1, in HIV-1 pathogenesis...
  4. Chen L, Glover J, Hogan P, Rao A, Harrison S. Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA. Nature. 1998;392:42-8 pubmed
    ..The tight association of the three proteins on DNA creates a continuous groove for the recognition of 15 base pairs. ..
  5. Lyakh L, Ghosh P, Rice N. Expression of NFAT-family proteins in normal human T cells. Mol Cell Biol. 1997;17:2475-84 pubmed
    ..Using a panel of specific antisera in immunoprecipitation assays, we found that NFATp (135 kDa) is constitutively expressed in normal human T cells, while synthesis of NFATc (predominant form of 86 ..
  6. Aramburu J, Garcia Cozar F, Raghavan A, Okamura H, Rao A, Hogan P. Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT. Mol Cell. 1998;1:627-37 pubmed
    ..a single residue in this sequence impairs the calcineurin-mediated dephosphorylation and nuclear translocation of NFAT1. Peptides spanning the region inhibit the ability of calcineurin to bind to and dephosphorylate NFAT proteins, ..
  7. Gibson H, Hedgcock C, Aufiero B, Wilson A, Hafner M, Tsokos G, et al. Induction of the CTLA-4 gene in human lymphocytes is dependent on NFAT binding the proximal promoter. J Immunol. 2007;179:3831-40 pubmed
    ..In addition, NFAT1 binds to the promoter of the CTLA-4 gene after stimulation by chromatin immunoprecipitation...
  8. Li X, Ho S, Luna J, Giacalone J, Thomas D, Timmerman L, et al. Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp. Cytogenet Cell Genet. 1995;68:185-91 pubmed
    ..as the pre-existing (p) and cytosolic (c) component of the NFAT transcription complex, NFATc of human and NFATp of murine origin (Northrop et al., 1994; McCaffrey et al., 1993b)...
  9. Northrop J, Ho S, Chen L, Thomas D, Timmerman L, Nolan G, et al. NF-AT components define a family of transcription factors targeted in T-cell activation. Nature. 1994;369:497-502 pubmed
    ..Agents that increase intracellular Ca2+ or activate protein kinase C independently modify NF-ATc, indicating that distinct signalling pathways converge on NF-ATc to regulate its function. ..
  10. Jain J, McCaffrey P, Miner Z, Kerppola T, Lambert J, Verdine G, et al. The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature. 1993;365:352-5 pubmed
    ..NFAT contains a subunit (NFATp) which is present in unstimulated T cells and which forms a complex with Fos and Jun proteins in the nucleus of ..
  11. Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan A, Stroud J, et al. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell. 2006;126:375-87 pubmed
    ..Thus by switching transcriptional partners, NFAT converts the acute T cell activation program into the suppressor program of Tregs. ..
  12. Hidalgo Estévez A, Gonzalez E, Punzon C, Fresno M. Human immunodeficiency virus type 1 Tat increases cooperation between AP-1 and NFAT transcription factors in T cells. J Gen Virol. 2006;87:1603-12 pubmed
    ..HIV-1 Tat interacted with NFAT but not c-Jun. These results indicate that Tat interacts with NFAT, affecting its cooperation with AP-1, without altering independent binding of these transcription factors to DNA. ..
  13. Hodge M, Chun H, Rengarajan J, Alt A, Lieberson R, Glimcher L. NF-AT-Driven interleukin-4 transcription potentiated by NIP45. Science. 1996;274:1903-5 pubmed
    ..The identification of NIP45 advances our understanding of gene activation of cytokines, critical mediators of the immune response. ..
  14. Duque J, Fresno M, Iñiguez M. Expression and function of the nuclear factor of activated T cells in colon carcinoma cells: involvement in the regulation of cyclooxygenase-2. J Biol Chem. 2005;280:8686-93 pubmed
    ..Here we provide evidence that NFATc1 and NFATc2 are expressed in human colon carcinoma cell lines...
  15. Okamura H, Garcia Rodriguez C, Martinson H, Qin J, Virshup D, Rao A. A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. Mol Cell Biol. 2004;24:4184-95 pubmed
    In resting cells, the NFAT1 transcription factor is kept inactive in the cytoplasm by phosphorylation on multiple serine residues...
  16. Mognol G, de Araujo Souza P, Robbs B, Teixeira L, Viola J. Transcriptional regulation of the c-Myc promoter by NFAT1 involves negative and positive NFAT-responsive elements. Cell Cycle. 2012;11:1014-28 pubmed publisher
    ..In this work, we demonstrate that the regulation of c-Myc by NFAT1 is more complex than previously conceived...
  17. Liao Q, Li Z, Chen R, Guo N, Zeng B, Cheng D, et al. [Effect of hepatitis C virus core gene transfection on NFAT1 expression in human intrahepatic cholangiocarcinoma cells]. Nan Fang Yi Ke Da Xue Xue Bao. 2012;32:789-93 pubmed
    To explore whether hepatitis C virus core protein (HCV C) regulates the expression of NFAT1 to participate in the progression and malignant biological behavior of intrahepatic cholangiocarcinoma cells...
  18. Baksh S, Widlund H, Frazer Abel A, Du J, Fosmire S, Fisher D, et al. NFATc2-mediated repression of cyclin-dependent kinase 4 expression. Mol Cell. 2002;10:1071-81 pubmed
    ..Ectopic expression of NFATc2 inhibited the basal activity of the human CDK4 promoter...
  19. Youn H, Chatila T, Liu J. Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis. EMBO J. 2000;19:4323-31 pubmed
    ..We report here that NFATp synergizes with MEF2D to recruit the coactivator p300 for the transcription of Nur77...
  20. Kinoshita S, Chen B, Kaneshima H, Nolan G. Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells. Cell. 1998;95:595-604 pubmed
    ..The host mechanisms regulated by such permissivity factors are potential targets for anti-HIV-1 therapy. ..
  21. Baumgart S, Glesel E, Singh G, Chen N, Reutlinger K, Zhang J, et al. Restricted heterochromatin formation links NFATc2 repressor activity with growth promotion in pancreatic cancer. Gastroenterology. 2012;142:388-98.e1-7 pubmed publisher
    ..Our study uncovered induction of NFATc2 in late-stage pancreatic intraepithelial neoplasia lesions with increased expression in tumor cell nuclei of ..
  22. Zheng J, Fang F, Zeng X, Medler T, Fiorillo A, Clevenger C. Negative cross talk between NFAT1 and Stat5 signaling in breast cancer. Mol Endocrinol. 2011;25:2054-64 pubmed publisher
    ..b>NFAT1 interacts with Stat5 in breast cancer cells, and their physical association is mediated by the DNA binding and ..
  23. Luo C, Burgeon E, Carew J, McCaffrey P, Badalian T, Lane W, et al. Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes. Mol Cell Biol. 1996;16:3955-66 pubmed
    ..We have identified two new isoforms of the transcription factor NFAT1 (previously termed NFATp) that are the predominant isoforms expressed in murine and human T cells...
  24. Rao A, Luo C, Hogan P. Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol. 1997;15:707-47 pubmed
  25. Ding Y, Huang Y, Song N, Gao X, Yuan S, Wang X, et al. NFAT1 mediates placental growth factor-induced myelomonocytic cell recruitment via the induction of TNF-alpha. J Immunol. 2010;184:2593-601 pubmed publisher
    ..In this study, we demonstrate that tumor-derived PlGF activates NFAT1 via vascular endothelial growth factor receptor 1 in both murine and human myelomonocytic cells...
  26. Westhorpe C, Norman M, Hall P, Snelgrove S, Finsterbusch M, Li A, et al. Effector CD4+ T cells recognize intravascular antigen presented by patrolling monocytes. Nat Commun. 2018;9:747 pubmed publisher
    ..Following intravascular deposition of antigen in glomeruli, effector CD4+ T-cell responses, including NFAT1 nuclear translocation and decreased migration, are consistent with antigen recognition...
  27. Mokrani M, Klibi J, Bluteau D, Bismuth G, Mami Chouaib F. Smad and NFAT pathways cooperate to induce CD103 expression in human CD8 T lymphocytes. J Immunol. 2014;192:2471-9 pubmed publisher
    ..Overall, our results explain how TGF-?1 can participate in CD103 expression on locally TCR-engaged Ag-specific CD8 T cells, thus contributing to antitumor CTL responses and cancer cell destruction. ..
  28. Dai S, Gu H, Lin Q, Xing T, Chen M, Zhong T, et al. Disequilibrium in the CD8+CD28+/CD8+CD28- T Lymphocyte Balance Is Related to Prognosis in Rats with Trinitrobenzenesulfonic Acid-Induced Colitis. Dig Dis Sci. 2017;62:639-651 pubmed publisher
    ..Immunohistochemistry and Western blotting were used to detect the colonic expression of JAK3, STAT6, NFATc2, and GATA3...
  29. Jiang Y, Han S, Cheng W, Wang Z, Wu A. NFAT1-regulated IL6 signalling contributes to aggressive phenotypes of glioma. Cell Commun Signal. 2017;15:54 pubmed publisher
    ..The effects of the nuclear factor of activated T cells-1 (NFAT1) on the promoter activities of IL6R and IL6 were also examined...
  30. de la Encarnación A, Alquézar C, Martín Requero Ã. Increased Wnt Signaling and Reduced Viability in a Neuronal Model of Progranulin-Deficient Frontotemporal Lobar Degeneration. Mol Neurobiol. 2016;53:7107-7118 pubmed
    ..nuclear content of β-catenin and higher levels of cyclin D1, or increased levels of the active form of the NFAT1 transcription factor, respectively...
  31. Mognol G, Carneiro F, Robbs B, Faget D, Viola J. Cell cycle and apoptosis regulation by NFAT transcription factors: new roles for an old player. Cell Death Dis. 2016;7:e2199 pubmed publisher
    ..nuclear factor of activated T cells) family of transcription factors consists of four Ca(2+)-regulated members (NFAT1-NFAT4), which were first described in T lymphocytes...
  32. O Rourke F, LaPlante J, Feinstein M. Antisense-mediated loss of calcium homoeostasis endoplasmic reticulum protein (CHERP; ERPROT213-21) impairs Ca2+ mobilization, nuclear factor of activated T-cells (NFAT) activation and cell proliferation in Jurkat T-lymphocytes. Biochem J. 2003;373:133-43 pubmed
    ..These findings provide further evidence that CHERP is an important component of the ER Ca(2+)-mobilizing system in cells, and its loss impairs Ca(2+)-dependent biochemical pathways and progression through the cell cycle. ..
  33. Lund S, Portillo A, Cavagnero K, Baum R, Naji L, Badrani J, et al. Leukotriene C4 Potentiates IL-33-Induced Group 2 Innate Lymphoid Cell Activation and Lung Inflammation. J Immunol. 2017;199:1096-1104 pubmed publisher
    ..CysLTs directly potentiated IL-5 and IL-13 production from purified ILC2s stimulated with IL-33 and resulted in NFAT1 nuclear translocation...
  34. Celil Aydemir A, Lee S, Won Kim D, Gardner T, Prince D, Mok Ahn J, et al. Nuclear factor of activated T cell mediates proinflammatory gene expression in response to mechanotransduction. Ann N Y Acad Sci. 2007;1117:138-42 pubmed
    ..Fluid shear stress (FSS)-induced effect was blocked by the inhibition of the calcineurin-NFATc1 axis, thus implicating a role for nuclear factor of activated T cells (NFAT) signaling in mechanotransduction. ..
  35. Dahiya S, Liu Y, Nonnemacher M, Dampier W, Wigdahl B. CCAAT enhancer binding protein and nuclear factor of activated T cells regulate HIV-1 LTR via a novel conserved downstream site in cells of the monocyte-macrophage lineage. PLoS ONE. 2014;9:e88116 pubmed publisher
    ..b>NFATc2 exhibited a higher relative affinity for DS3 as compared with members of the C/EBP family (C/EBP ? and ?)...
  36. Liu W, Youn H, Zhou X, Lu K, Liu J. Binding and regulation of the transcription factor NFAT by the peptidyl prolyl cis-trans isomerase Pin1. FEBS Lett. 2001;496:105-8 pubmed
    ..These results suggest a possible role for Pin1 in the regulation of NFAT in T cells. ..
  37. Martinez G, Hu J, Pereira R, Crampton J, Togher S, Bild N, et al. Cutting Edge: NFAT Transcription Factors Promote the Generation of Follicular Helper T Cells in Response to Acute Viral Infection. J Immunol. 2016;196:2015-9 pubmed publisher
    ..In this article, we show that deficiency in NFAT1 and NFAT2 in CD4(+) T cells leads to impaired germinal center reactions upon viral infection because of reduced ..
  38. Eriksson J, Le Joncour V, Nummela P, Jahkola T, Virolainen S, Laakkonen P, et al. Gene expression analyses of primary melanomas reveal CTHRC1 as an important player in melanoma progression. Oncotarget. 2016;7:15065-92 pubmed publisher
    ..regulated coordinately with fibronectin and integrin ?3 by the pro-invasive and -angiogenic transcription factor NFATC2. We also found CTHRC1 to be a target of TFG? and BRAF...
  39. Cho J, Han J. Phospholipase D and Its Essential Role in Cancer. Mol Cells. 2017;: pubmed publisher
    ..target of proteins that contribute to inflammation and carcinogenesis such as Sp1, NF?B, TCF4, ATF-2, NFATc2, and EWS-Fli...
  40. Teixeira L, Carrossini N, Sécca C, Kroll J, DaCunha D, Faget D, et al. NFAT1 transcription factor regulates cell cycle progression and cyclin E expression in B lymphocytes. Cell Cycle. 2016;15:2346-59 pubmed publisher
    ..However, the specific role of the NFAT1 family member in naive B cell proliferation remains elusive...
  41. Garcia Rodriguez C, Rao A. Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP). J Exp Med. 1998;187:2031-6 pubmed
    ..The NH2-terminal transactivation domain of NFAT1 and the phospho-CREB- and E1A-binding sites of p300/CBP are involved in the interaction...
  42. Gerçek M, Gerçek M, Kant S, Simsekyilmaz S, Kassner A, Milting H, et al. Cardiomyocyte Hypertrophy in Arrhythmogenic Cardiomyopathy. Am J Pathol. 2017;187:752-766 pubmed publisher
    ..Nfat) signaling, which is linked to pathological hypertrophy, is observed during AC progression, as evidenced by Nfatc2 and Nfatc3 mRNA in cardiomyocytes and increased mRNA of the Nfat target regulator of calcineurin 1...
  43. Bandukwala H, Wu Y, Feuerer M, Chen Y, Barboza B, Ghosh S, et al. Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells. Immunity. 2011;34:479-91 pubmed publisher
    ..of the FOXP3 forkhead domain as a ternary complex with the DNA-binding domain of the transcription factor NFAT1 and a DNA oligonucleotide from the interleukin-2 promoter...
  44. Szeto G, Pomerantz J, Graham D, Clements J. Minocycline suppresses activation of nuclear factor of activated T cells 1 (NFAT1) in human CD4+ T cells. J Biol Chem. 2011;286:11275-82 pubmed publisher
    ..transcriptional activation, a result of increased phosphorylation and reduced nuclear translocation of the isoform NFAT1. Minocycline increased the activity of the NFAT kinase GSK3 and decreased intracellular Ca(2+) flux, both of which ..
  45. Courtwright A, Siamakpour Reihani S, Arbiser J, Banet N, Hilliard E, Fried L, et al. Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway. Cancer Res. 2009;69:4621-8 pubmed publisher
    ..04). In conclusion, SFRP2 is a novel stimulator of angiogenesis that stimulates angiogenesis via a calcineurin/NFAT pathway and may be a favorable target for the inhibition of angiogenesis in solid tumors. ..
  46. Yao J, Zhao Q, Liu D, Chow C, Mei Y. Neuritin Up-regulates Kv4.2 ?-Subunit of Potassium Channel Expression and Affects Neuronal Excitability by Regulating the Calcium-Calcineurin-NFATc4 Signaling Pathway. J Biol Chem. 2016;291:17369-81 pubmed publisher
    ..and IA densities; this effect was sensitive to CaN inhibition and was eliminated in Nfatc4(-/-) mice but not in Nfatc2(-/-) mice...
  47. Shoshan E, Braeuer R, Kamiya T, Mobley A, Huang L, Vasquez M, et al. NFAT1 Directly Regulates IL8 and MMP3 to Promote Melanoma Tumor Growth and Metastasis. Cancer Res. 2016;76:3145-55 pubmed publisher
    Nuclear factor of activated T cell (NFAT1, NFATC2) is a transcription factor that binds and positively regulates IL2 expression during T-cell activation...
  48. Hayashida N, Fujimoto M, Tan K, Prakasam R, Shinkawa T, Li L, et al. Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT. EMBO J. 2010;29:3459-69 pubmed publisher
    ..Among them, we show that one of the nuclear factor of activated T cells (NFAT) proteins, NFATc2, significantly inhibits polyQ aggregation in cells and is required for HSF1-mediated suppression of polyQ ..
  49. Guasch A, Aranguren Ibáñez Ã, Pérez Luque R, Aparicio D, Martínez Høyer S, Mulero M, et al. Calcineurin Undergoes a Conformational Switch Evoked via Peptidyl-Prolyl Isomerization. PLoS ONE. 2015;10:e0134569 pubmed publisher
    ..Alternative conformations in PPPs provide a new perspective on interactions with substrates and other protein partners and may foster development of more specific inhibitors as drug candidates. ..
  50. Bettelli E, Dastrange M, Oukka M. Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proc Natl Acad Sci U S A. 2005;102:5138-43 pubmed
  51. Kądziołka B, Leśniak W, Filipek A. Regulation of CacyBP/SIP expression by NFAT1 transcription factor. Immunobiology. 2017;222:872-877 pubmed publisher
    In this work we have shown that NFAT1 transcription factor is involved in the regulation of CacyBP/SIP expression...
  52. Decker E, Nehmann N, Kampen E, Eibel H, Zipfel P, Skerka C. Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression. Nucleic Acids Res. 2003;31:911-21 pubmed
    ..Using tagged NFATc and NFATp in glutathione S-transferase pull down assays showed interaction and physical complex formation of each NFAT ..
  53. Perotti V, Baldassari P, Bersani I, Molla A, Vegetti C, Tassi E, et al. NFATc2 is a potential therapeutic target in human melanoma. J Invest Dermatol. 2012;132:2652-60 pubmed publisher
    ..Here we show that the calcineurin/nuclear factor of activated T cells c2 (NFATc2) pathway has an antiapoptotic role in melanoma cells...
  54. Vieira L, Vaz A, Matos P, Ambrósio A, Nogueira M, Marques B, et al. Three-way translocation (X;20;16)(p11;q13;q23) in essential thrombocythemia implicates NFATC2 in dysregulation of CSF2 expression and megakaryocyte proliferation. Genes Chromosomes Cancer. 2012;51:1093-108 pubmed publisher
    ..The deletion encompassed the nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (NFATC2) gene that encodes a transcription factor involved in the regulation of hematopoietic cytokines...
  55. Wang P, Mao Y, Razo J, Zhou X, Wong S, Patel S, et al. Using genetic and clinical factors to predict tacrolimus dose in renal transplant recipients. Pharmacogenomics. 2010;11:1389-402 pubmed publisher
    ..Our results highlight the importance of incorporating both genetic and clinical, demographic factors into dose prediction. ..
  56. Gómez Casero E, San Antonio B, Iñiguez M, Fresno M. Cot/Tpl2 and PKCzeta cooperate in the regulation of the transcriptional activity of NFATc2 through the phosphorylation of its amino-terminal domain. Cell Signal. 2007;19:1652-61 pubmed
    ..We have analyzed the regulation of NFATc2 activation by Cot/Tpl2 and protein kinase C zeta (PKCzeta) in T cells...
  57. Walczak Drzewiecka A, Ratajewski M, Wagner W, Dastych J. HIF-1alpha is up-regulated in activated mast cells by a process that involves calcineurin and NFAT. J Immunol. 2008;181:1665-72 pubmed
    ..Thus, accumulation of HIF-1alpha in activated mast cells requires up-regulation of HIF1A gene transcription and depends on the calcineurin-NFAT signaling pathway. ..
  58. Kar P, Mirams G, Christian H, Parekh A. Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca2+ Signals. Mol Cell. 2016;64:746-759 pubmed publisher
    ..Here, we show that two Ca2+-dependent transcription factor isoforms, NFAT1 and NFAT4, require distinct sub-cellular InsP3 and Ca2+ signals for physiologically ..
  59. Zhou Z, Song J, Li W, Liu X, Cao L, Wan L, et al. The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin/NFAT1 axis. J Exp Clin Cancer Res. 2017;36:130 pubmed publisher
    ..Chromatin immunoprecipitation-sequencing was used to uncover the binding sites of NFAT1. Finally, we examined the expression of ASIC2 in CRC tissues using immunohistochemistry...
  60. Ram B, Dolpady J, Kulkarni R, Usha R, Bhoria U, Poli U, et al. Human papillomavirus (HPV) oncoprotein E6 facilitates Calcineurin-Nuclear factor for activated T cells 2 (NFAT2) signaling to promote cellular proliferation in cervical cell carcinoma. Exp Cell Res. 2018;362:132-141 pubmed publisher
    ..The nuclear levels of both NFAT1 and NFAT3 remain unaltered implicating they have little role in cervical carcinogenesis...
  61. Diehl S, Chow C, Weiss L, Palmetshofer A, Twardzik T, Rounds L, et al. Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation. J Exp Med. 2002;196:39-49 pubmed
    ..IL-6 upregulates NFAT transcriptional activity by increasing the levels of NFATc2. The ability of IL-6 to promote Th2 differentiation is impaired in CD4+ T cells that lack NFATc2, demonstrating ..
  62. Jinnin M, Medici D, Park L, Limaye N, Liu Y, Boscolo E, et al. Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma. Nat Med. 2008;14:1236-46 pubmed publisher
  63. Yao X, Yang Y, He H, Wang M, Yin K, Huang M. GATA3 siRNA inhibits the binding of NFAT1 to interleukin-13 promoter in human T cells. Chin Med J (Engl). 2010;123:739-44 pubmed
    ..Transcription factors GATA3 and NFAT1 have been both implicated in the regulation of Th2 cytokines...
  64. Ikeda F, Nishimura R, Matsubara T, Hata K, Reddy S, Yoneda T. Activation of NFAT signal in vivo leads to osteopenia associated with increased osteoclastogenesis and bone-resorbing activity. J Immunol. 2006;177:2384-90 pubmed
    ..Thus, we generated transgenic mice in which constitutively active-NFAT1/NFATc2 (CA-NFAT1) is specifically expressed in the osteoclast lineage, using the tartrate-resistant acid phosphatase gene ..
  65. Singh S, Baumgart S, Singh G, König A, Reutlinger K, Hofbauer L, et al. Disruption of a nuclear NFATc2 protein stabilization loop confers breast and pancreatic cancer growth suppression by zoledronic acid. J Biol Chem. 2011;286:28761-71 pubmed publisher
    ..Here, we demonstrate the existence of a nuclear GSK-3?-NFATc2 stabilization pathway that promotes breast and pancreatic cancer growth in vitro and in vivo and serves as a bona ..
  66. Park K, Park J, Yang W, Lee J, Song M, Kim H. Transcriptional activation of the IL31 gene by NFAT and STAT6. J Leukoc Biol. 2012;91:245-57 pubmed publisher
    ..STAT6 binding sites, calcium responsiveness of IL-31 promoter required NFAT binding sites that bind NFATc1 and NFATc2 in vitro and in vivo...
  67. Lahti A, Manninen A, Saksela K. Regulation of T cell activation by HIV-1 accessory proteins: Vpr acts via distinct mechanisms to cooperate with Nef in NFAT-directed gene expression and to promote transactivation by CREB. Virology. 2003;310:190-6 pubmed
    ..These results provide additional evidence for cell cycle-independent regulation of gene expression by Vpr and implicate CREB as a potentially important target for Vpr action in HIV-infected host cells. ..
  68. Gonzalez Hernandez M, Swanson M, Contreras Galindo R, Cookinham S, King S, Noel R, et al. Expression of human endogenous retrovirus type K (HML-2) is activated by the Tat protein of HIV-1. J Virol. 2012;86:7790-805 pubmed publisher
    ..These studies demonstrate that HIV-1 Tat plays an important role in activating expression of HERV-K (HML-2) in the setting of HIV-1 infection. ..
  69. Goyal A, Poluzzi C, Willis C, Smythies J, Shellard A, Neill T, et al. Endorepellin affects angiogenesis by antagonizing diverse vascular endothelial growth factor receptor 2 (VEGFR2)-evoked signaling pathways: transcriptional repression of hypoxia-inducible factor 1? and VEGFA and concurrent inhibition of nuclear facto. J Biol Chem. 2012;287:43543-56 pubmed publisher
    ..the PKC/JNK/AP1 axis induced by the recruitment of phospholipase ? and attenuated the VEGFA-induced activation of NFAT1, a process dependent on calcineurin activity...
  70. Tie X, Han S, Meng L, Wang Y, Wu A. NFAT1 is highly expressed in, and regulates the invasion of, glioblastoma multiforme cells. PLoS ONE. 2013;8:e66008 pubmed publisher
    ..A prominent member of this family, NFAT1, is associated with tumor cell survival, apoptosis, migration and invasion...
  71. Victoriano A, Okamoto T. Transcriptional control of HIV replication by multiple modulators and their implication for a novel antiviral therapy. AIDS Res Hum Retroviruses. 2012;28:125-38 pubmed publisher
    ..We include recent findings on chromatin remodeling toward HIV transcription and its therapeutic implication is also discussed. The current status of small-molecular-weight compounds that affect HIV transcription is also described. ..
  72. Berglund L, Kotova O, Osmark P, Grufman H, Xing C, Lydrup M, et al. NFAT regulates the expression of AIF-1 and IRT-1: yin and yang splice variants of neointima formation and atherosclerosis. Cardiovasc Res. 2012;93:414-23 pubmed publisher
    ..Inhibition of NFAT signalling, by shifting the AIF-1/IRT-1 ratio, may be an attractive target to regulate the VSMC response to injury and manipulate plaque stability in atherosclerosis. ..
  73. Guo Z, Xu P, Ge S, Zhang C, Zheng X, Xu J, et al. Ubiquitin specific peptidase 4 stabilizes interferon regulatory factor protein and promotes its function to facilitate interleukin-4 expression in T helper type 2 cells. Int J Mol Med. 2017;40:979-986 pubmed publisher
    ..reporter gene constructs were used to analyze the effects of USP4, IRF4 and nuclear factor of activated T cell-2 (NFATc2) on the activation of the interleukin-4 (IL-4) promoter...
  74. Kyttaris V, Wang Y, Juang Y, Weinstein A, Tsokos G. Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus. J Immunol. 2007;178:1960-6 pubmed
    ..The absence of important transcriptional activators (AP-1, NF-kappaBeta) and the presence of transcriptional repressors (cAMP response element modulator) on the IL-2 promoter explain this dichotomous effect. ..
  75. Kipanyula M, Woodhoo A, Rahman M, Payne D, Jessen K, Mirsky R. Calcineurin-nuclear factor of activated T cells regulation of Krox-20 expression in Schwann cells requires elevation of intracellular cyclic AMP. J Neurosci Res. 2013;91:105-15 pubmed publisher
    ..HA-NFAT1 (1-460)-GFP translocated to the nucleus on treatment with dibutyryl cAMP with or without added ionophore...
  76. Lo Y, Wu C, Shih H, Lai M. Selective activation of NFAT by promyelocytic leukemia protein. Oncogene. 2008;27:3821-30 pubmed publisher
    ..The unexpected coupling of PML with NFAT reveals a novel mechanism underlying the diverse physiological functions of PML. ..
  77. Jabado N, Le Deist F, Fisher A, Hivroz C. Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity. Eur J Immunol. 1994;24:2646-52 pubmed