Gene Symbol: NFATC1
Description: nuclear factor of activated T cells 1
Alias: NF-ATC, NF-ATc1.2, NFAT2, NFATc, nuclear factor of activated T-cells, cytoplasmic 1, NFAT transcription complex cytosolic component, nuclear factor of activated T-cells 'c', nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Species: human
Products:     NFATC1

Top Publications

  1. Northrop J, Ho S, Chen L, Thomas D, Timmerman L, Nolan G, et al. NF-AT components define a family of transcription factors targeted in T-cell activation. Nature. 1994;369:497-502 pubmed
    ..Agents that increase intracellular Ca2+ or activate protein kinase C independently modify NF-ATc, indicating that distinct signalling pathways converge on NF-ATc to regulate its function. ..
  2. Park J, Takeuchi A, Sharma S. Characterization of a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc. J Biol Chem. 1996;271:20914-21 pubmed
    ..The cDNA clone encodes a new isoform, NFATc.beta, of the NFAT gene family member NFATc (designated here NFATc.alpha). The amino acid sequence of NFATc...
  3. Chuvpilo S, Zimmer M, Kerstan A, Glockner J, Avots A, Escher C, et al. Alternative polyadenylation events contribute to the induction of NF-ATc in effector T cells. Immunity. 1999;10:261-9 pubmed
    ..These alternative polyadenylation events ensure the rapid accumulation of high concentrations of NF-ATc necessary to exceed critical threshold levels of NF-ATc for gene induction in effector T cells. ..
  4. Crabtree G. Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT. Cell. 1999;96:611-4 pubmed
  5. Manninen A, Renkema G, Saksela K. Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway. J Biol Chem. 2000;275:16513-7 pubmed
  6. Manninen A, Saksela K. HIV-1 Nef interacts with inositol trisphosphate receptor to activate calcium signaling in T cells. J Exp Med. 2002;195:1023-32 pubmed
  7. Duque J, Fresno M, Iñiguez M. Expression and function of the nuclear factor of activated T cells in colon carcinoma cells: involvement in the regulation of cyclooxygenase-2. J Biol Chem. 2005;280:8686-93 pubmed
    ..Here we provide evidence that NFATc1 and NFATc2 are expressed in human colon carcinoma cell lines...
  8. Shih T, Hsieh S, Hsieh Y, Chen T, Yeh C, Lin C, et al. Aberrant activation of nuclear factor of activated T cell 2 in lamina propria mononuclear cells in ulcerative colitis. World J Gastroenterol. 2008;14:1759-67 pubmed
    To investigate the role of nuclear factor of activated T cell 2 (NFAT2), the major NFAT protein in peripheral T cells, in sustained T cell activation and intractable inflammation in human ulcerative colitis (UC)...
  9. Kinoshita S, Su L, Amano M, Timmerman L, Kaneshima H, Nolan G. The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells. Immunity. 1997;6:235-44 pubmed
    ..These results link regulatory factors critical to T cell commitment directly to HIV-1 replication. ..

More Information

Publications108 found, 100 shown here

  1. Rao A, Luo C, Hogan P. Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol. 1997;15:707-47 pubmed
  2. Kinoshita S, Chen B, Kaneshima H, Nolan G. Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells. Cell. 1998;95:595-604 pubmed
    ..We show that the transcription factor NFATc was sufficient as a cellular factor to induce a highly permissive state for HIV-1 replication in primary CD4+ T ..
  3. Wang J, Kiyokawa E, Verdin E, Trono D. The Nef protein of HIV-1 associates with rafts and primes T cells for activation. Proc Natl Acad Sci U S A. 2000;97:394-9 pubmed
    ..Overall, these data suggest that Nef acts at the level of rafts to prime T cells for activation. Likely consequences of this effect are the promotion of HIV-1 replication and the facilitation of virus spread. ..
  4. Horsley V, Pavlath G. NFAT: ubiquitous regulator of cell differentiation and adaptation. J Cell Biol. 2002;156:771-4 pubmed
    ..This review addresses the recent data implicating NFAT in the control of gene expression influencing the development and adaptation of numerous mammalian cell types. ..
  5. Jauliac S, Lopez Rodriguez C, Shaw L, Brown L, Rao A, Toker A. The role of NFAT transcription factors in integrin-mediated carcinoma invasion. Nat Cell Biol. 2002;4:540-4 pubmed
    ..These observations show that NFATs are targets of alpha(6)beta(4) integrin signalling and are involved in promoting carcinoma invasion, highlighting a novel function for this family of transcription factors in human cancer. ..
  6. Wilkins B, De Windt L, Bueno O, Braz J, Glascock B, Kimball T, et al. Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth. Mol Cell Biol. 2002;22:7603-13 pubmed
    ..NFATc3-null mice also demonstrated attenuated pressure overload- and angiotensin II-induced cardiac hypertrophy. These results provide genetic evidence that calcineurin-regulated responses require NFAT effectors in vivo. ..
  7. Tuosto L, Marinari B, Andreotti M, Federico M, Piccolella E. Vav exchange factor counteracts the HIV-1 Nef-mediated decrease of plasma membrane GM1 and NF-AT activity in T cells. Eur J Immunol. 2003;33:2186-96 pubmed
  8. Rosenkranz A, Rauch B, Freidel K, Schror K. Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT. Cardiovasc Res. 2009;83:778-84 pubmed publisher
    ..The NFAT inhibitor cyclosporin A (CsA) or NFAT2 siRNA both reduced PAR-1 mRNA and protein expression and prevented the stimulatory effects of thrombin or PAR-1 ..
  9. Li X, Ho S, Luna J, Giacalone J, Thomas D, Timmerman L, et al. Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp. Cytogenet Cell Genet. 1995;68:185-91 pubmed
    ..capable of functioning as the pre-existing (p) and cytosolic (c) component of the NFAT transcription complex, NFATc of human and NFATp of murine origin (Northrop et al., 1994; McCaffrey et al., 1993b)...
  10. Beals C, Sheridan C, Turck C, Gardner P, Crabtree G. Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science. 1997;275:1930-4 pubmed
    ..Because GSK-3 responds to signals initiated by Wnt and other ligands, NF-AT family members could be effectors of these pathways. ..
  11. Manninen A, Huotari P, Hiipakka M, Renkema G, Saksela K. Activation of NFAT-dependent gene expression by Nef: conservation among divergent Nef alleles, dependence on SH3 binding and membrane association, and cooperation with protein kinase C-theta. J Virol. 2001;75:3034-7 pubmed
    ..Cotransfection of an activated protein kinase C-theta (PKC-theta) with Nef implicated PKC-theta as a possible physiological cofactor of Nef in promoting NFAT-dependent gene expression and T-cell activation. ..
  12. Bettelli E, Dastrange M, Oukka M. Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proc Natl Acad Sci U S A. 2005;102:5138-43 pubmed
  13. Fenard D, Yonemoto W, de Noronha C, Cavrois M, Williams S, Greene W. Nef is physically recruited into the immunological synapse and potentiates T cell activation early after TCR engagement. J Immunol. 2005;175:6050-7 pubmed
    ..g., activated p21-activated kinase-2) into the immunological synapse may underlie the increased frequency of cells expressing transcriptionally active forms of NF-kappaB and NFAT and the resultant changes in T cell activation. ..
  14. Mirza F, Lorenzo J, Drissi H, Lee F, Soung D. Dried plum alleviates symptoms of inflammatory arthritis in TNF transgenic mice. J Nutr Biochem. 2017;52:54-61 pubmed publisher
    ..and mRNA levels of cathepsin K and MMP9 through inhibition of nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) expression and nuclear factor kappa B (NF-?B) activation...
  15. Choe J, Kim S. Melittin inhibits osteoclast formation through the downregulation of the RANKL-RANK signaling pathway and the inhibition of interleukin-1? in murine macrophages. Int J Mol Med. 2017;39:539-548 pubmed publisher
    ..the p65 subunit of nuclear factor-?B (NF-?B), c-Fos, c-Jun, nuclear factor of activated T cells, cytoplasmic 1 (NFATc1), TNF receptor-associated factor-6 (TRAF6), and interleukin-1? (IL-1?) were assessed by western blot analysis...
  16. Strack J, Heni H, Gilsbach R, Hein L, Aktories K, Orth J. Noncanonical G-protein-dependent modulation of osteoclast differentiation and bone resorption mediated by Pasteurella multocida toxin. MBio. 2014;5:e02190 pubmed publisher
    ..protein kinase pathway results in stimulation of the osteoclastogenic transcription factors AP-1, NF-κB, and NFATc1. In addition, Ca(2+)-dependent calcineurin activation of NFAT is crucial for PMT-induced osteoclastogenesis...
  17. Cary R, Waddell S, Racioppi L, Long F, Novack D, Voor M, et al. Inhibition of Ca²?/calmodulin-dependent protein kinase kinase 2 stimulates osteoblast formation and inhibits osteoclast differentiation. J Bone Miner Res. 2013;28:1599-610 pubmed publisher significantly reduced levels of its transcriptional target, nuclear factor of activated T cells, cytoplasmic (NFATc1)...
  18. Yang J, Park O, Kim J, Baik J, Yun C, Han S. Lipoteichoic Acid of Enterococcus faecalis Inhibits the Differentiation of Macrophages into Osteoclasts. J Endod. 2016;42:570-4 pubmed publisher
    ..The expression of NFATc1 and c-Fos transcription factors was determined by Western blotting...
  19. Yu H, Herbert B, Valerio M, Yarborough L, Hsu L, Argraves K. FTY720 inhibited proinflammatory cytokine release and osteoclastogenesis induced by Aggregatibacter actinomycetemcomitans. Lipids Health Dis. 2015;14:66 pubmed publisher
    ..of osteoclastogenic factors, including nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 (Nfatc1), cathepsin K (Ctsk), acid phosphatase 5 (Acp5), osteoclast-associated receptor (Oscar), and RANKL were quantified ..
  20. Park M, Lee S, Lee S, Kim E, Lee E, Moon Y, et al. GRIM19 ameliorates acute graft-versus-host disease (GVHD) by modulating Th17 and Treg cell balance through down-regulation of STAT3 and NF-AT activation. J Transl Med. 2016;14:206 pubmed publisher
    ..from GRIM19-overexpressing cells downregulated the expression of nuclear factor of activated T cells (NFATc1) but promoted the expression of regulator of calcineurin (RCAN)3 while downregulating NFAT-dependent cytokine gene ..
  21. Ravel Chapuis A, Belanger G, Cote J, Michel R, Jasmin B. Misregulation of calcium-handling proteins promotes hyperactivation of calcineurin-NFAT signaling in skeletal muscle of DM1 mice. Hum Mol Genet. 2017;26:2192-2206 pubmed publisher
    ..Coherent with this, we found that activators of the CnA pathway (MLP, FHL1) are also elevated. Consequently, NFATc1 expression is increased in DM1 muscle and becomes relocalized to myonuclei, together with an up-regulation of its ..
  22. Song J, Jing Z, Hu W, Yu J, Cui X. ?-Linolenic Acid Inhibits Receptor Activator of NF-?B Ligand Induced (RANKL-Induced) Osteoclastogenesis and Prevents Inflammatory Bone Loss via Downregulation of Nuclear Factor-KappaB-Inducible Nitric Oxide Synthases (NF-?B-iNOS) Signaling Pathways. Med Sci Monit. 2017;23:5056-5069 pubmed
    ..ALA suppressed the RANKL-induced osteoclast markers c-Fos, c-Jun and NFATc1 together with transcription factor proteins TRAP, OSCAR, cathepsin K and ?3-integrin...
  23. Thummuri D, Jeengar M, Shrivastava S, Nemani H, Ramavat R, Chaudhari P, et al. Thymoquinone prevents RANKL-induced osteoclastogenesis activation and osteolysis in an in vivo model of inflammation by suppressing NF-KB and MAPK Signalling. Pharmacol Res. 2015;99:63-73 pubmed publisher
    ..RANKL induced phosphorylation of MAPKs and mRNA expression of osteoclastic specific genes such as TRAP, DC-STAMP, NFATc1 and c-Fos. In addition, TQ also decreased the RANKL stimulated ROS generation in macropahges (RAW 264...
  24. Mateu Jimenez M, Cucarull Martínez B, Yelamos J, Barreiro E. Reduced tumor burden through increased oxidative stress in lung adenocarcinoma cells of PARP-1 and PARP-2 knockout mice. Biochimie. 2016;121:278-86 pubmed publisher
    ..reduction in tumor burden most likely through alterations in redox balance (downregulation of antioxidants, NFATc-2 and miR223, and increased oxidative stress), which in turn led to increased apoptosis and autophagy...
  25. Kar P, Samanta K, Kramer H, Morris O, Bakowski D, Parekh A. Dynamic assembly of a membrane signaling complex enables selective activation of NFAT by Orai1. Curr Biol. 2014;24:1361-1368 pubmed publisher
    ..The formation of a store-dependent signaling complex at the plasma membrane provides for selective activation of a fundamental downstream response by Orai1. ..
  26. Mao L, Xia L, Chang J, Liu J, Jiang L, Wu C, et al. The synergistic effects of Sr and Si bioactive ions on osteogenesis, osteoclastogenesis and angiogenesis for osteoporotic bone regeneration. Acta Biomater. 2017;61:217-232 pubmed publisher
    ..stage, but also repressed RANKL-induced osteoclast formation and expression of TRAP, DC-STAMP, V-ATPase a3, and NFATc1. The synergistic effects of Sr and Si ions were further investigated as compared with those of similar ..
  27. Koltsova E, Wiest D, Vavilova T. Transcription factors NFAT2 and Egr1 cooperatively regulate the maturation of T-lymphoma in vitro. Biochemistry (Mosc). 2007;72:954-61 pubmed
    We have demonstrated that transcription factors Egr1 and NFAT2 cooperate in regulation of the early stages of T-lymphocyte development, whereas the related factors Egr2 and Egr3 do not cooperate with NFAT2...
  28. Yarilina A, Xu K, Chen J, Ivashkiv L. TNF activates calcium-nuclear factor of activated T cells (NFAT)c1 signaling pathways in human macrophages. Proc Natl Acad Sci U S A. 2011;108:1573-8 pubmed publisher
    ..TNF-induced NFATc1 activity primed macrophages for enhanced osteoclastogenesis in response to RANKL...
  29. Sengupta S, Jana S, Biswas S, Mandal P, Bhattacharyya A. Cooperative involvement of NFAT and SnoN mediates transforming growth factor-? (TGF-?) induced EMT in metastatic breast cancer (MDA-MB 231) cells. Clin Exp Metastasis. 2013;30:1019-31 pubmed publisher
    ..All of these observations provide a fresh mechanism in which by a twofold involvement of NFAT and SnoN plays a crucial role in TGF-? mediated EMT by recruiting the effector molecules N-cadherin and MMP-2, MMP-9. ..
  30. Kawahara T, Kashiwagi E, Ide H, Li Y, Zheng Y, Ishiguro H, et al. The role of NFATc1 in prostate cancer progression: cyclosporine A and tacrolimus inhibit cell proliferation, migration, and invasion. Prostate. 2015;75:573-84 pubmed publisher
    ..We aim to investigate biological significance of NFATc1, a NFAT isoform shown to function as an oncogene in a sarcoma model, in human prostate cancer...
  31. Witwicka H, Hwang S, Reyes Gutiérrez P, Jia H, Odgren P, Donahue L, et al. Studies of OC-STAMP in Osteoclast Fusion: A New Knockout Mouse Model, Rescue of Cell Fusion, and Transmembrane Topology. PLoS ONE. 2015;10:e0128275 pubmed publisher
    ..Expression levels of other osteoclast markers, such as cathepsin K, carbonic anhydrase II, and NFATc1, were not significantly different compared to wild type...
  32. Pedigo C, Ducasa G, Leclercq F, Sloan A, Mitrofanova A, Hashmi T, et al. Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury. J Clin Invest. 2016;126:3336-50 pubmed publisher cholesterol-dependent apoptosis in podocytes was mediated by nuclear factor of activated T cells 1 (NFATc1)...
  33. Kwon M, Kim J, Lee K, Park S, Lim H, Kim T, et al. Synchronized Cell Cycle Arrest Promotes Osteoclast Differentiation. Int J Mol Sci. 2016;17: pubmed publisher
    ..progenitors into multinucleated osteoclasts expressing high levels of osteoclast marker proteins such as NFATc1, c-Fos, Atp6v0d2, cathepsin K, and integrin ?3 on subsequent exposure to M-CSF and RANKL...
  34. Strålberg F, Kassem A, Kasprzykowski F, Abrahamson M, Grubb A, Lindholm C, et al. Inhibition of lipopolysaccharide-induced osteoclast formation and bone resorption in vitro and in vivo by cysteine proteinase inhibitors. J Leukoc Biol. 2017;101:1233-1243 pubmed publisher
    ..acid phosphatase (TRAP) and cathepsin K and of the osteoclastogenic transcription factors c-Fos and NFATc1. LPS-induced osteoclast formation on bone slices was also inhibited by cystatin C, resulting in decreased pit ..
  35. Kawahara T, Inoue S, Fujita K, Mizushima T, Ide H, Yamaguchi S, et al. NFATc1 Expression as a Prognosticator in Urothelial Carcinoma of the Upper Urinary Tract. Transl Oncol. 2017;10:318-323 pubmed publisher
    We recently found that NFATc1, a member of the NFAT family and a key regulator of the immune response, could induce bladder carcinogenesis and cancer progression...
  36. Kim J, Yang J, Han B, Kwon H, Kim J, Choi S. Protective Role of Apelin Against Cyclosporine-Induced Renal Tubular Injury in Rats. Transplant Proc. 2017;49:1499-1509 pubmed publisher
    ..Western blotting for endothelial nitric oxide synthase and nuclear factor of activated T-cell cytoplasmic 1 (NFATc1) to document the underlying mechanism...
  37. Cheng J, Zhou L, Liu Q, Tickner J, Tan Z, Li X, et al. Cyanidin Chloride inhibits ovariectomy-induced osteoporosis by suppressing RANKL-mediated osteoclastogenesis and associated signaling pathways. J Cell Physiol. 2017;: pubmed publisher
    ..RANKL-induced calcium oscillations, the activation of nuclear factor of activated T cells calcineurin-dependent 1 (NFATc1), and the expression of c-Fos...
  38. Chai R, McDonald M, Terry R, Kovacic N, Down J, Pettitt J, et al. Melphalan modifies the bone microenvironment by enhancing osteoclast formation. Oncotarget. 2017;8:68047-68058 pubmed publisher
    ..the microphthalmia-associated transcription factor (MITF), but not nuclear factor of activated T cells 1 (NFATc1)...
  39. Park K, Gu D, Jin S, Yoon C, Ko W, Kim Y, et al. Pueraria lobate Inhibits RANKL-Mediated Osteoclastogenesis Via Downregulation of CREB/PGC1?/c-Fos/NFATc1 Signaling. Am J Chin Med. 2017;:1-20 pubmed publisher
    ..significantly repressed the expression of c-Fos and the nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), which is a master transcription factor for osteoclastogenesis in vitro and in vivo...
  40. Huang Y, Chen S, Liu R, Chen Y, Lin C, Huang C, et al. CLEC5A is critical for dengue virus-induced osteoclast activation and bone homeostasis. J Mol Med (Berl). 2016;94:1025-37 pubmed publisher
    ..Interestingly, DV-induced cytokine secretion and nuclear translocation of the transcription factor NFATc1 in osteoclast via the Syk-coupled myeloid C-type lectin member 5A (CLEC5A)...
  41. Izawa T, Mori H, Shinohara T, Mino Oka A, Hutami I, Iwasa A, et al. Rebamipide Attenuates Mandibular Condylar Degeneration in a Murine Model of TMJ-OA by Mediating a Chondroprotective Effect and by Downregulating RANKL-Mediated Osteoclastogenesis. PLoS ONE. 2016;11:e0154107 pubmed publisher
    ..Rebamipide also suppressed the activation of transcription factors (e.g., NF-κB, NFATc1) and mitogen-activated protein kinases (MAPK) by receptor activator of nuclear factor kappa-B ligand (RANKL) to ..
  42. Kadlub N, Sessiecq Q, Dainese L, Joly A, Lehalle D, Marlin S, et al. Defining a new aggressiveness classification and using NFATc1 localization as a prognostic factor in cherubism. Hum Pathol. 2016;58:62-71 pubmed publisher evaluate the osteoclastogenesis phenotype by histologic examination of nuclear factor of activated T cells 1 (NFATc1) localization and tartrate-resistant acid phosphatase (TRAP) activity and to correlate the results to disease ..
  43. Müller H, Caballé Serrano J, Lussi A, Gruber R. Inhibitory effect of saliva on osteoclastogenesis in vitro requires toll-like receptor 4 signaling. Clin Oral Investig. 2017;21:2445-2452 pubmed publisher
    ..TAK-242 also supported the expression of NFATc1, the master regulator of osteoclastogenesis, as well as DC-STAMP and Atp6v0d2, both being cell fusion genes...
  44. Weng J, Wang C, Zhong W, Li B, Wang Z, Shao C, et al. Activation of CD137 Signaling Promotes Angiogenesis in Atherosclerosis via Modulating Endothelial Smad1/5-NFATc1 Pathway. J Am Heart Assoc. 2017;6: pubmed publisher
    ..of Smad1/5 and nuclear translocation of p-Smad1/5, which in turn promotes the expression and translocation of NFATc1. Blocking CD137 signaling with inhibitory anti-CD137 antibody could inhibit this activation and attenuated agonist ..
  45. Kum C, Kim E, Kim J, Lee B, Min J, Heo J, et al. Cyperus Rotundus L. extract suppresses RANKL-induced osteoclastogenesis through NFATc1/c-fos downregulation and prevent bone loss in OVX-induced osteoporosis rat. J Ethnopharmacol. 2017;205:186-194 pubmed publisher
    ..of tartrate-resistant acid phosphatase (TRAP) multinucleated cells, pit formation, transcription factors such as NFATc1 and c-Fos, and mRNA expression of osteoclast-associated genes were investigated...
  46. Doraczynska Kowalik A, Nelke K, Pawlak W, Sasiadek M, Gerber H. Genetic Factors Involved in Mandibular Prognathism. J Craniofac Surg. 2017;28:e422-e431 pubmed publisher
    ..On the other hand, MYH1, MYH2, MYH3, MYH7, MYH8, FOXO3, NFATC1, PTGS2, KAT6B, HDAC4, and RUNX2 expression is suspected to be involved in the epigenetic regulations behind the ..
  47. Yang G, Chen X, Yan Z, Zhu Q, Yang C. CD11b promotes the differentiation of osteoclasts induced by RANKL through the spleen tyrosine kinase signalling pathway. J Cell Mol Med. 2017;21:3445-3452 pubmed publisher
    ..the levels of spleen tyrosine kinase (Syk), c-Fos and nuclear factor of activated T cells, cytoplasmic-1 (NFATc1), as well as the activity of extracellular-regulated kinase (Erk), and as a result, osteoclast precursors (OCPs) ..
  48. Miyazaki M, Fujikawa Y, Takita C, Tsumura H. Tacrolimus and cyclosporine A inhibit human osteoclast formation via targeting the calcineurin-dependent NFAT pathway and an activation pathway for c-Jun or MITF in rheumatoid arthritis. Clin Rheumatol. 2007;26:231-9 pubmed
    ..transcription factors, such as TNF receptor-associated factor 6 (TRAF6), nuclear factor of activated T cells c1 (NFATc1), c-Fos, c-Jun, microphthalmia transcription factor (MITF) and PU...
  49. Trifari S, Sitia G, Aiuti A, Scaramuzza S, Marangoni F, Guidotti L, et al. Defective Th1 cytokine gene transcription in CD4+ and CD8+ T cells from Wiskott-Aldrich syndrome patients. J Immunol. 2006;177:7451-61 pubmed
    ..Together, our data indicate that WASP regulates the transcriptional activation of T cells and is required specifically for Th1 cytokine production. ..
  50. Belibasakis G, Emingil G, Saygan B, Turkoglu O, Atilla G, Bostanci N. Gene expression of transcription factor NFATc1 in periodontal diseases. APMIS. 2011;119:167-72 pubmed publisher
    ..T cells is regulated by the induction of transcription factor nuclear factor of activated T cells, cytoplasmic 1 (NFATc1). There is as yet no information on the potential involvement of NFATc1 in periodontal diseases...
  51. Kim J, Min J, Baek J, Ahn S, Jun H, Yoon K, et al. CTRP3 acts as a negative regulator of osteoclastogenesis through AMPK-c-Fos-NFATc1 signaling in vitro and RANKL-induced calvarial bone destruction in vivo. Bone. 2015;79:242-51 pubmed publisher
    ..with CTRP3 significantly inhibited RANKL-induced expression of c-Fos and nuclear factor of activated T-cells (NFATc1), essential transcription factors for osteoclast development...
  52. Nikhil K, Sharan S, Roy P. A pterostilbene derivative suppresses osteoclastogenesis by regulating RANKL-mediated NFκB and MAPK signaling in RAW264.7 cells. Pharmacol Rep. 2015;67:1264-72 pubmed publisher
    ..metalloproteinase 9 (MMP9) and transcription factors c-Fos, and nuclear factor of activated T cells cytoplasmic 1 (NFATc1) were also diminished by PTERC-T...
  53. Li Z, Cao L, Wang Y, Zhang Z, Fan M, Xu Q. Inhibitory effect of 1,25-dihydroxyvitamin D3 on Porphyromonas gingivalis-induced inflammation and bone resorption in vivo. Arch Oral Biol. 2016;72:146-156 pubmed publisher
    ..Real-time PCR was used to assess the mRNA expressions of OPG, RANKL, c-Fos, NFATc1, CTSK and TRAP in calvarial bone and IL-6, IL-10, IL-1?, IL-12p40 and TNF-? in soft tissue...
  54. Kumar R, Raman R, Kotapalli V, Gowrishankar S, Pyne S, Pollack J, et al. Ca2+/nuclear factor of activated T cells signaling is enriched in early-onset rectal tumors devoid of canonical Wnt activation. J Mol Med (Berl). 2018;96:135-146 pubmed publisher
    ..We confirmed the validated genes to be transcriptionally regulated by NFATc1 by (a) evaluating their respective transcript levels and (b) performing promoter-luciferase and chromatin ..
  55. Dankbar B, Fennen M, Brunert D, Hayer S, Frank S, Wehmeyer C, et al. Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice. Nat Med. 2015;21:1085-90 pubmed publisher
    ..formation in vitro through transcription factor SMAD2-dependent regulation of nuclear factor of activated T-cells (NFATC1)...
  56. Di Ceglie I, van den Akker G, Ascone G, Ten Harkel B, Hacker H, van de Loo F, et al. Genetic modification of ER-Hoxb8 osteoclast precursors using CRISPR/Cas9 as a novel way to allow studies on osteoclast biology. J Leukoc Biol. 2017;101:957-966 pubmed publisher
    ..We genetically modified ER-Hoxb8 cells with success, generating NFATc1-/- and DC-STAMP-/- ER-Hoxb8 cells that lack the ability to differentiate into osteoclasts or ..
  57. Baer A, Colon Moran W, Xiang J, Stapleton J, Bhattarai N. Src-family kinases negatively regulate NFAT signaling in resting human T cells. PLoS ONE. 2017;12:e0187123 pubmed publisher
    ..Together, these data identified a novel role of SFKs in preventing aberrant NFAT1 activation in resting T cells, and suggest that maintaining this pool of active SFKs in therapeutic T cells may increase the efficacy of T cell therapies. ..
  58. Grössinger E, Kang M, Bouchareychas L, Sarin R, Haudenschild D, Borodinsky L, et al. Ca2+-Dependent Regulation of NFATc1 via KCa3.1 in Inflammatory Osteoclastogenesis. J Immunol. 2018;200:749-757 pubmed publisher
    ..Ca2+-calmodulin kinase IV (CaMKIV) induces transcriptional regulation of osteoclast-specific genes via NFATc1, which facilitate bone resorption...
  59. San Antonio B, Iñiguez M, Fresno M. Protein kinase Czeta phosphorylates nuclear factor of activated T cells and regulates its transactivating activity. J Biol Chem. 2002;277:27073-80 pubmed
    ..PKCzeta cooperates with calcium ionophore and with NFAT1 or NFAT2 proteins to enhance transcriptional activation of a NFAT reporter construct...
  60. Rainio E, Sandholm J, Koskinen P. Cutting edge: Transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase. J Immunol. 2002;168:1524-7 pubmed
    ..In this study we demonstrate that Pim-1 can physically interact with the NFATc1 transcription factor and phosphorylate it in vitro on several serine residues...
  61. Gitler A, Zhu Y, Ismat F, Lu M, Yamauchi Y, Parada L, et al. Nf1 has an essential role in endothelial cells. Nat Genet. 2003;33:75-9 pubmed
    ..level of ras signaling in Nf1(-/-) endothelial cells and greater nuclear localization of the transcription factor Nfatc1. Inactivation of Nf1 in the neural crest does not cause cardiac defects but results in tumors of neural-crest ..
  62. Matsumoto M, Kogawa M, Wada S, Takayanagi H, Tsujimoto M, Katayama S, et al. Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1. J Biol Chem. 2004;279:45969-79 pubmed
    ..constructs of the cathepsin K gene promoter indicates that limited sets of the transcription factors such as NFATc1, PU...
  63. Puri S, Magenheimer B, Maser R, Ryan E, Zien C, Walker D, et al. Polycystin-1 activates the calcineurin/NFAT (nuclear factor of activated T-cells) signaling pathway. J Biol Chem. 2004;279:55455-64 pubmed
  64. Kaminuma O, Kitamura F, Kitamura N, Hiroi T, Miyoshi H, Miyawaki A, et al. Differential contribution of NFATc2 and NFATc1 to TNF-alpha gene expression in T cells. J Immunol. 2008;180:319-26 pubmed
    ..This study investigated the relative contribution of NFATc2 and NFATc1 to the transactivation of cytokine genes in T cells...
  65. Le Roy C, Deglesne P, Chevallier N, Beitar T, Eclache V, Quettier M, et al. The degree of BCR and NFAT activation predicts clinical outcomes in chronic lymphocytic leukemia. Blood. 2012;120:356-65 pubmed publisher
    ..The calcium-calcineurin-dependent transcription factor NFAT2 is up-regulated and to some extent constitutively activated in all CLL B cells...
  66. Wang S, Kang X, Cao S, Cheng H, Wang D, Geng J. Calcineurin/NFATc1 pathway contributes to cell proliferation in hepatocellular carcinoma. Dig Dis Sci. 2012;57:3184-8 pubmed publisher
    ..Expression of NFATc1 and calcineurin proteins was examined by immunohistochemical analyses in 76 human HCC samples...
  67. Markle T, Philip M, Brockman M. HIV-1 Nef and T-cell activation: a history of contradictions. Future Virol. 2013;8: pubmed publisher
  68. Jin Y, Stohn J, Wang Q, Nagano K, Baron R, Bouxsein M, et al. Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1. Bone. 2017;97:153-167 pubmed publisher
    ..osteoclast activity together with enhanced expression of osteoclastogenic genes such as c-Fos, Rankl, Trap, and Nfatc1. Differentiation of bone marrow-derived monocytes isolated from Cthrc1 null mice differentiated into osteoclasts ..
  69. Guo J, Li W, Wu Y, Jing X, Huang J, Zhang J, et al. Meclizine Prevents Ovariectomy-Induced Bone Loss and Inhibits Osteoclastogenesis Partially by Upregulating PXR. Front Pharmacol. 2017;8:693 pubmed publisher
    ..On the one hand, at the molecular level, meclizine attenuated RANKL-induced activation of c-Fos, NFATc1, nuclear factor-?B (NF-?B) and mitogen-activated protein kinase (MAPKs), including ERK and p38, but not JNK...
  70. Yang Y, Fu Q, Liu Y, Wang X, Dunham R, Liu S, et al. Comparative transcriptome analysis reveals conserved branching morphogenesis related genes involved in chamber formation of catfish swimbladder. Physiol Genomics. 2017;:physiolgenomics.00089.2017 pubmed publisher
    ..Among these DEGs, members of the Wnt signaling pathway (wnt1, wnt2, nfatc1, rac2), Hedgehog signaling pathway (shh), and growth factors (fgf10, igf-1) were identified...
  71. Liu L, Peng Z, Xu Z, Huang H, Wei X. Mouse embryonic fibroblast (MEF)/BMP4-conditioned medium enhanced multipotency of human dental pulp cells. J Mol Histol. 2018;49:17-26 pubmed publisher
    ..Expression of BMP4/NFATc1/LIF in the co-culture medium was evaluated by ELISA and expression of Oct-4/Sox2/c-Myc/NFATc1 in co-cultured DPCs ..
  72. Vacca A, Farina M, Maroder M, Alesse E, Screpanti I, Frati L, et al. Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif. Biochem Biophys Res Commun. 1994;205:467-74 pubmed
    ..Our data suggest that tat links T cell activating signals to the shared IL-2 and HIV regulation. This may play a role in the early phase of HIV infection. ..
  73. Yehya A, Souki R, Bitar F, Nemer G. Differential duplication of an intronic region in the NFATC1 gene in patients with congenital heart disease. Genome. 2006;49:1092-8 pubmed
    ..b>NFATC1 belongs to the Rel family of transcription factors...
  74. Jang G, Park I, Yang J, Bischoff J, Lee Y. Differential functions of genes regulated by VEGF-NFATc1 signaling pathway in the migration of pulmonary valve endothelial cells. FEBS Lett. 2010;584:141-6 pubmed publisher
    ..Here we show that VEGF-A increases the migration of HPVECs through NFATc1 activation, suggesting that VEGF-A/NFATc1 regulates the migration of HPVECs...
  75. Alvarez S, Blanco A, Fresno M, Muñoz Fernandez M. TNF-? contributes to caspase-3 independent apoptosis in neuroblastoma cells: role of NFAT. PLoS ONE. 2011;6:e16100 pubmed publisher
    ..These data demonstrate that TNF-? promotes FasL expression through NFAT activation in neuroblastoma cells and this event leads to increased apoptosis through independent caspase-3 activation. ..
  76. Fujino T, Ide T, Yoshida M, Onitsuka K, Tanaka A, Hata Y, et al. Recombinant mitochondrial transcription factor A protein inhibits nuclear factor of activated T cells signaling and attenuates pathological hypertrophy of cardiac myocytes. Mitochondrion. 2012;12:449-58 pubmed publisher
    ..rhTFAM attenuated subsequent morphological hypertrophy of myocytes as well. rhTFAM would be an attractive molecule in attenuating cardiac pathological hypertrophy. ..
  77. Dong M, Hiwasa T, Cong B, Shi Q, Wang S, Kita K, et al. Protein kinase Cα-mediated cytotoxic activity of ineupatorolide B from Inula cappa DC. in HeLa cells. Int J Oncol. 2015;47:1839-44 pubmed publisher
    ..Knockdown of PKCα using siRNA attenuated the cytotoxic activity of InB. Thus, InB may exhibit growth-inhibitory activity through the activation of PKCα, followed by an increase in NFAT transactivation ability. ..
  78. Kim H, Kang W, Seong S, Kim S, Lim M, Yoon Y. Follistatin-like 1 promotes osteoclast formation via RANKL-mediated NF-?B activation and M-CSF-induced precursor proliferation. Cell Signal. 2016;28:1137-44 pubmed publisher
    ..FSTL1 (rFSTL1) in BMMs enhances the formation of multinuclear osteoclasts and the induction of c-Fos and NFATc1, transcription factors important for osteoclastogenesis...
  79. Baud huin M, Lamoureux F, Jacques C, Rodriguez Calleja L, Quillard T, Charrier C, et al. Inhibition of BET proteins and epigenetic signaling as a potential treatment for osteoporosis. Bone. 2017;94:10-21 pubmed publisher
    ..Mechanistically, JQ1 inhibits expression of the master osteoclast transcription factor NFATc1 and the transcription factor of osteoblast Runx2...
  80. Wang Y, Xiu Y, Bi K, Ou J, Gu W, Wang W, et al. Integrated analysis of mRNA-seq in the haemocytes of Eriocheir sinensis in response to Spiroplasma eriocheiris infection. Fish Shellfish Immunol. 2017;68:289-298 pubmed publisher
    ..We found important immune-related genes (GNPTAB, MASP2, F7, F5, NFATC, TRAF6, MAP3K5, and TRa) in the KEGG pathway, and those genes were confirmed by qRT-PCR analysis...
  81. Zhang H, Liang S, Du Y, Li R, He C, Wang W, et al. Inducible ATF3-NFAT axis aggravates podocyte injury. J Mol Med (Berl). 2018;96:53-64 pubmed publisher
    ..ATF3 directly modulates the regulation of NFATc1 gene promoter activity and alters the expression of Wnt6 and Fzd9, direct target genes of NFATc1 signaling...
  82. Heuser C, Gotot J, Piotrowski E, Philipp M, Courrèges C, Otte M, et al. Prolonged IKK? Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells. Cell Rep. 2017;21:578-586 pubmed publisher
    ..were resistant to IKK? inhibition because other pathways, in particular nuclear factor of activated T cells (NFATc1) signaling, sustained their survival and expansion...
  83. Baek K, Park H, Baek J, Kim H. Isoproterenol Increases RANKL Expression in a ATF4/NFATc1-Dependent Manner in Mouse Osteoblastic Cells. Int J Mol Sci. 2017;18: pubmed publisher
    ..Isoproterenol increased nuclear factor of activated T-cells cytoplasmic 1 (NFATc1) and RANKL expressions at both mRNA and protein levels and increased NFAT reporter activity...
  84. Choi Y, Asada S, Uesugi M. Divergent hTAFII31-binding motifs hidden in activation domains. J Biol Chem. 2000;275:15912-6 pubmed
    ..The interaction surfaces are localized in short peptide segments of activation domains. The brevity and heterogeneity of the motifs may explain the low sequence homology among acidic activation domains. ..
  85. Schroeder J, Miura K, Kim H, Sin A, Cianferoni A, Casolaro V. Selective expression of nuclear factor of activated T cells 2/c1 in human basophils: evidence for involvement in IgE-mediated IL-4 generation. J Allergy Clin Immunol. 2002;109:507-13 pubmed
    ..Basophils constitutively expressed high levels of NFAT2. In contrast, NFAT1 (NFATp), which is found in most leukocytes, was not seen in basophils...
  86. Tolstrup M, Ostergaard L, Laursen A, Pedersen S, Duch M. HIV/SIV escape from immune surveillance: focus on Nef. Curr HIV Res. 2004;2:141-51 pubmed
    ..Here we review the multitude of functions exerted by Nef and discuss the functional domains of the protein in terms of cellular interaction partners and the effect of nef mutations in the course of AIDS disease progression. ..
  87. Amaral F, Brito J, Perdigão P, Carvalho V, de Souza P, Gomez M, et al. NFATc1 and TNFalpha expression in giant cell lesions of the jaws. J Oral Pathol Med. 2010;39:269-74 pubmed publisher
    ..effect of SH3BP2 gene mutations on the transcription of the downstream genes nuclear factor of activated T cells (NFATc1) and the cytokine tumor necrosis factor-alpha (TNF-alpha) was also investigated together with the ..
  88. Ishiguro K, Ando T, Maeda O, Watanabe O, Goto H. Cutting edge: tubulin ? functions as an adaptor in NFAT-importin ? interaction. J Immunol. 2011;186:2710-3 pubmed publisher
    ..In conclusion, tubulin ? functions as an adaptor in NFAT-importin ? interaction, and this function is regulated by acetate-induced acetylation...
  89. Kaminuma O, Kitamura N, Mori A, Tatsumi H, Nemoto S, Hiroi T. NFAT1 and NFAT2 differentially regulate IL-17A expression in human T cells. Int Arch Allergy Immunol. 2012;158 Suppl 1:30-4 pubmed publisher
    ..In this study, the relative contribution of NFAT1 and NFAT2 to IL-17A expression in human T cells was investigated...
  90. Mena M, Papiewska Pajak I, Przygodzka P, Kozaczuk A, Boncela J, Cierniewski C. NFAT2 regulates COX-2 expression and modulates the integrin repertoire in endothelial cells at the crossroads of angiogenesis and inflammation. Exp Cell Res. 2014;324:124-36 pubmed publisher
    ..In this paper, we show that: (a) COX-2 expression induced by VEGF-A is NFAT2-dependent; and (b) the integrin profile in endothelial cells induced by the pro-angiogenic VEGF-A is distinct from ..
  91. Stringhini S, Polidoro S, Sacerdote C, Kelly R, van Veldhoven K, Agnoli C, et al. Life-course socioeconomic status and DNA methylation of genes regulating inflammation. Int J Epidemiol. 2015;44:1320-30 pubmed publisher
    ..Indicators of SES were associated with DNA methylation of genes involved in inflammation. NFATC1, in particular, was consistently found to be less methylated in individuals with low vs high SES, in a dose-..
  92. Li L, Yu J, Duan Z, Dang H. The effect of NFATc1 on vascular generation and the possible underlying mechanism in epithelial ovarian carcinoma. Int J Oncol. 2016;48:1457-66 pubmed publisher
    We investigated the effect of nuclear factor of activated T cells c1 (NFATc1) on the growth and vascular generation of human ovarian carcinoma SKOV3 cell-transplanted tumors in nude mice and explored the possible underlying mechanism...