NFATC1

Summary

Gene Symbol: NFATC1
Description: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Alias: NF-ATC, NFAT2, NFATc, NFAT transcription complex cytosolic component, nuclear factor of activated T-cells, cytoplasmic 1
Species: human

Top Publications

  1. ncbi Transcription factors of the NFAT family: regulation and function
    A Rao
    Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 15:707-47. 1997
  2. ncbi The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells
    S Kinoshita
    Department of Molecular Pharmacology, Stanford University School of Medicine, California 94305, USA
    Immunity 6:235-44. 1997
  3. ncbi Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1
    Masahito Matsumoto
    Department of Molecular Biology, Saitama Medical School, Saitama, Japan
    J Biol Chem 279:45969-79. 2004
  4. ncbi Vav exchange factor counteracts the HIV-1 Nef-mediated decrease of plasma membrane GM1 and NF-AT activity in T cells
    Loretta Tuosto
    Department of Cellular and Developmental Biology, La Sapienza University, Rome, Italy
    Eur J Immunol 33:2186-96. 2003
  5. pmc Expression of human endogenous retrovirus type K (HML-2) is activated by the Tat protein of HIV-1
    Marta J Gonzalez-Hernandez
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    J Virol 86:7790-805. 2012
  6. ncbi Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway
    A Manninen
    Institute of Medical Technology, University of Tampere, P O Box 607, FIN 33101 and the Department of Clinical Chemistry, Tampere University Hospital, P O Box 2000, FIN 33521, Tampere, Finland
    J Biol Chem 275:16513-7. 2000
  7. ncbi Cutting edge: Transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase
    Eeva Marja Rainio
    Turku Centre for Biotechnology, University of Turku Abo Akademi University, and Turku Graduate School of Biomedical Sciences, Turku, Finland
    J Immunol 168:1524-7. 2002
  8. ncbi The role of NFAT transcription factors in integrin-mediated carcinoma invasion
    Sebastien Jauliac
    Department of Pathology, Harvard Medical School and Beth Israel Deaconess Medical Center, 200 Longwood Avenue, Boston MA 02115, USA
    Nat Cell Biol 4:540-4. 2002
  9. pmc HIV-1 Nef interacts with inositol trisphosphate receptor to activate calcium signaling in T cells
    Aki Manninen
    Institute of Medical Technology, University of Tampere, Tampere FIN 33014, Finland
    J Exp Med 195:1023-32. 2002
  10. pmc Counteraction of HLA-C-mediated immune control of HIV-1 by Nef
    Anke Specht
    Institute of Molecular Virology, University Hospital of Ulm, Meyerhofstr 1, 89081 Ulm, Germany
    J Virol 84:7300-11. 2010

Research Grants

  1. TRAF6 E3 LIGASE FUNCTION IN OSTEOCLASTOGENESIS
    Bryant Darnay; Fiscal Year: 2007
  2. Role of Twisted Gastrulation in Osteoclastogenesis
    Rajaram Gopalakrishnan; Fiscal Year: 2010
  3. TRAF6 E3 LIGASE FUNCTION IN OSTEOCLASTOGENESIS
    Bryant G Darnay; Fiscal Year: 2010
  4. Regulatory mechanisms in osteoclasts
    Yongwon Choi; Fiscal Year: 2010
  5. Mi: Modulating Osteoclast Gene Expression and Function
    Michael C Ostrowski; Fiscal Year: 2010
  6. Mi: Modulating Osteoclast Gene Expression and Function
    Michael Ostrowski; Fiscal Year: 2009
  7. STUDIES OF THE FATE OF THE OSTEOCLAST
    BRENDAN BOYCE; Fiscal Year: 2009
  8. STUDIES OF THE FATE OF THE OSTEOCLAST
    Brendan F Boyce; Fiscal Year: 2010
  9. RANK Signaling in Osteoclast Differentiation and Function
    Xu Feng; Fiscal Year: 2010
  10. RANK Signaling in Osteoclast Differentiation and Function
    Xu Feng; Fiscal Year: 2007

Detail Information

Publications201 found, 100 shown here

  1. ncbi Transcription factors of the NFAT family: regulation and function
    A Rao
    Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 15:707-47. 1997
    ....
  2. ncbi The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells
    S Kinoshita
    Department of Molecular Pharmacology, Stanford University School of Medicine, California 94305, USA
    Immunity 6:235-44. 1997
    ..These results link regulatory factors critical to T cell commitment directly to HIV-1 replication...
  3. ncbi Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1
    Masahito Matsumoto
    Department of Molecular Biology, Saitama Medical School, Saitama, Japan
    J Biol Chem 279:45969-79. 2004
    ..constructs of the cathepsin K gene promoter indicates that limited sets of the transcription factors such as NFATc1, PU...
  4. ncbi Vav exchange factor counteracts the HIV-1 Nef-mediated decrease of plasma membrane GM1 and NF-AT activity in T cells
    Loretta Tuosto
    Department of Cellular and Developmental Biology, La Sapienza University, Rome, Italy
    Eur J Immunol 33:2186-96. 2003
    ....
  5. pmc Expression of human endogenous retrovirus type K (HML-2) is activated by the Tat protein of HIV-1
    Marta J Gonzalez-Hernandez
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    J Virol 86:7790-805. 2012
    ..These studies demonstrate that HIV-1 Tat plays an important role in activating expression of HERV-K (HML-2) in the setting of HIV-1 infection...
  6. ncbi Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway
    A Manninen
    Institute of Medical Technology, University of Tampere, P O Box 607, FIN 33101 and the Department of Clinical Chemistry, Tampere University Hospital, P O Box 2000, FIN 33521, Tampere, Finland
    J Biol Chem 275:16513-7. 2000
    ....
  7. ncbi Cutting edge: Transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase
    Eeva Marja Rainio
    Turku Centre for Biotechnology, University of Turku Abo Akademi University, and Turku Graduate School of Biomedical Sciences, Turku, Finland
    J Immunol 168:1524-7. 2002
    ..In this study we demonstrate that Pim-1 can physically interact with the NFATc1 transcription factor and phosphorylate it in vitro on several serine residues...
  8. ncbi The role of NFAT transcription factors in integrin-mediated carcinoma invasion
    Sebastien Jauliac
    Department of Pathology, Harvard Medical School and Beth Israel Deaconess Medical Center, 200 Longwood Avenue, Boston MA 02115, USA
    Nat Cell Biol 4:540-4. 2002
    ..These observations show that NFATs are targets of alpha(6)beta(4) integrin signalling and are involved in promoting carcinoma invasion, highlighting a novel function for this family of transcription factors in human cancer...
  9. pmc HIV-1 Nef interacts with inositol trisphosphate receptor to activate calcium signaling in T cells
    Aki Manninen
    Institute of Medical Technology, University of Tampere, Tampere FIN 33014, Finland
    J Exp Med 195:1023-32. 2002
    ....
  10. pmc Counteraction of HLA-C-mediated immune control of HIV-1 by Nef
    Anke Specht
    Institute of Molecular Virology, University Hospital of Ulm, Meyerhofstr 1, 89081 Ulm, Germany
    J Virol 84:7300-11. 2010
    ..Thus, while high HLA-C expression may generally facilitate control of HIV-1, Nef may counteract HLA-C-mediated immune control in some individuals indirectly, by manipulating T-cell function and MHC-II antigen presentation...
  11. ncbi Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT
    G R Crabtree
    Department of Pathology, Stanford University Medical School, California 94062, USA
    Cell 96:611-4. 1999
  12. ncbi Inhibition of AMP-activated protein kinase suppresses IL-2 expression through down-regulation of NF-AT and AP-1 activation in Jurkat T cells
    Bong Sook Jhun
    Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 130 701, Republic of Korea
    Biochem Biophys Res Commun 351:986-92. 2006
    ..These results suggest that AMPK mediates IL-2 production by regulating NF-AT and AP-1activation during T cell stimulation...
  13. doi Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT
    Anke C Rosenkranz
    Institut fur Pharmakologie und Klinische Pharmakologie, Heinrich Heine Universitat Dusseldorf, Universitatsstrasse 1, 40225 Dusseldorf, Germany
    Cardiovasc Res 83:778-84. 2009
    ..This study examines the downstream mechanisms, particularly the role of nuclear factor of activated T-cells (NFAT)...
  14. ncbi Inhibition of cellular functions of HIV-1 Nef by artificial SH3 domains
    M Hiipakka
    Institute of Medical Technology, University of Tampere, Tampere, FIN 33014, Finland
    Virology 286:152-9. 2001
    ..Thus, RT-loop-modified SH3 domains represent a novel approach for selectively interfering with cellular signaling events, which could be exploited in research as well as in therapeutic applications...
  15. pmc The Nef protein of HIV-1 associates with rafts and primes T cells for activation
    J K Wang
    Department of Genetics and Microbiology, University of Geneva, CH 1211 Geneva, Switzerland
    Proc Natl Acad Sci U S A 97:394-9. 2000
    ..Overall, these data suggest that Nef acts at the level of rafts to prime T cells for activation. Likely consequences of this effect are the promotion of HIV-1 replication and the facilitation of virus spread...
  16. doi 1-Alpha, 25-dihydroxy vitamin D3 inhibits osteoclastogenesis through IFN-beta-dependent NFATc1 suppression
    Sadaoki Sakai
    Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Bone Miner Metab 27:643-52. 2009
    ..1alpha,25(OH)(2)D(3) inhibited the expression of nuclear factor of activated T cells c1 (NFATc1, also referred as NFAT2), an essential transcription factor for osteoclast differentiation, and upregulated the ..
  17. pmc Aberrant activation of nuclear factor of activated T cell 2 in lamina propria mononuclear cells in ulcerative colitis
    Tsung Chieh Shih
    Clinical Proteomics Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
    World J Gastroenterol 14:1759-67. 2008
    To investigate the role of nuclear factor of activated T cell 2 (NFAT2), the major NFAT protein in peripheral T cells, in sustained T cell activation and intractable inflammation in human ulcerative colitis (UC).
  18. doi PU.1 and NFATc1 mediate osteoclastic induction of the mouse beta3 integrin promoter
    Tania N Crotti
    The New England Baptist Bone and Joint Institute, Department of Rheumatology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Physiol 215:636-44. 2008
    ..We previously showed that an evolutionary conserved NFATc1 binding site is required for RANKL induction and NFATc1 transactivation of the human beta(3) promoter...
  19. pmc Activation of NFAT-dependent gene expression by Nef: conservation among divergent Nef alleles, dependence on SH3 binding and membrane association, and cooperation with protein kinase C-theta
    A Manninen
    Institute of Medical Technology, University of Tampere, FIN 33014 Tampere, Finland
    J Virol 75:3034-7. 2001
    ..Cotransfection of an activated protein kinase C-theta (PKC-theta) with Nef implicated PKC-theta as a possible physiological cofactor of Nef in promoting NFAT-dependent gene expression and T-cell activation...
  20. ncbi Endothelin-1-dependent nuclear factor of activated T lymphocyte signaling associates with transcriptional coactivator p300 in the activation of the B cell leukemia-2 promoter in cardiac myocytes
    Teruhisa Kawamura
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Circ Res 94:1492-9. 2004
    ..We show here that p300 markedly potentiates the binding of NFATc1 to the bcl-2 NFAT element by interacting with NFATc1 in an E1A-dependent manner...
  21. ncbi MCP-1-induced human osteoclast-like cells are tartrate-resistant acid phosphatase, NFATc1, and calcitonin receptor-positive but require receptor activator of NFkappaB ligand for bone resorption
    Michael S Kim
    School of Medical Science, Griffith University Gold Coast Campus, Queensland, Australia
    J Biol Chem 281:1274-85. 2006
    ..of other osteoclast markers, including nuclear factor of activated t cells, cytoplasmic, calcineurin-dependent 1 (NFATc1)...
  22. ncbi Nucleolin modulates the subcellular localization of GDNF-inducible zinc finger protein 1 and its roles in transcription and cell proliferation
    Atsushi Dambara
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Exp Cell Res 313:3755-66. 2007
    ..Finally, we found that knockdown of GZF1 and nucleolin expression markedly impaired cell proliferation. These findings suggest that the physiological functions of GZF1 may be regulated by the protein's association with nucleolin...
  23. pmc Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells
    Estelle Bettelli
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:5138-43. 2005
    ....
  24. pmc NFAT: ubiquitous regulator of cell differentiation and adaptation
    Valerie Horsley
    Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
    J Cell Biol 156:771-4. 2002
    ..This review addresses the recent data implicating NFAT in the control of gene expression influencing the development and adaptation of numerous mammalian cell types...
  25. ncbi Human immunodeficiency virus type 1 Tat increases cooperation between AP-1 and NFAT transcription factors in T cells
    Alicia M Hidalgo-Estévez
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Gen Virol 87:1603-12. 2006
    ..HIV-1 Tat interacted with NFAT but not c-Jun. These results indicate that Tat interacts with NFAT, affecting its cooperation with AP-1, without altering independent binding of these transcription factors to DNA...
  26. ncbi HIV-1 gp120 induces NFAT nuclear translocation in resting CD4+ T-cells
    Claudia Cicala
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1876, USA
    Virology 345:105-14. 2006
    ..These observations provide insight into a potential mechanism by which HIV is able to establish infection in resting cells, which may have implications for both transmission of HIV and the persistence of viral reservoirs...
  27. ncbi Polycystin-1 activates the calcineurin/NFAT (nuclear factor of activated T-cells) signaling pathway
    Sanjeev Puri
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    J Biol Chem 279:55455-64. 2004
    ....
  28. pmc Epigenetic changes and suppression of the nuclear factor of activated T cell 1 (NFATC1) promoter in human lymphomas with defects in immunoreceptor signaling
    Askar Akimzhanov
    Institute of Pathology, University of Wuerzburg, Josef Schneider Strasse 2, D 97080 Wuerzburg, Germany
    Am J Pathol 172:215-24. 2008
    The nuclear factor of activated T cell 1 (Nfatc1) locus is a common insertion site for murine tumorigenic retroviruses, suggesting a role of transcription factor NFATc1 in lymphomagenesis...
  29. ncbi Regulation of T cell activation by HIV-1 accessory proteins: Vpr acts via distinct mechanisms to cooperate with Nef in NFAT-directed gene expression and to promote transactivation by CREB
    Anna L Lahti
    Institute of Medical Technology, FIN 33014 University of Tampere, Tampere, Finland
    Virology 310:190-6. 2003
    ..These results provide additional evidence for cell cycle-independent regulation of gene expression by Vpr and implicate CREB as a potentially important target for Vpr action in HIV-infected host cells...
  30. ncbi Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp
    X Li
    Howard Hughes Medical Institute, Stanford University Medical Center, CA 94305 5428
    Cytogenet Cell Genet 68:185-91. 1995
    ..capable of functioning as the pre-existing (p) and cytosolic (c) component of the NFAT transcription complex, NFATc of human and NFATp of murine origin (Northrop et al., 1994; McCaffrey et al., 1993b)...
  31. ncbi Alternative polyadenylation events contribute to the induction of NF-ATc in effector T cells
    S Chuvpilo
    Department of Molecular Pathology, Institute of Pathology, University of Wurzburg, Germany
    Immunity 10:261-9. 1999
    ..These alternative polyadenylation events ensure the rapid accumulation of high concentrations of NF-ATc necessary to exceed critical threshold levels of NF-ATc for gene induction in effector T cells...
  32. ncbi Characterization of a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc
    J Park
    Department of Pathology, Roger Williams Medical Center Brown University, Providence, Rhode Island 02908, USA
    J Biol Chem 271:20914-21. 1996
    ..The cDNA clone encodes a new isoform, NFATc.beta, of the NFAT gene family member NFATc (designated here NFATc.alpha). The amino acid sequence of NFATc...
  33. ncbi Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering
    M M Di Somma
    Department of Evolutionary Biology, University of Siena, Italy
    Eur J Immunol 26:2181-8. 1996
    ..A functional analysis of different CD4 epitopes using either anti-CD4 mAb or HIV-1 gp120 reveals a common epitope-specific activation of both the LTR and of the transcription factors NF-kappa B and NF-AT...
  34. ncbi Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity
    N Jabado
    INSERM U 132, Hopital, Necker Enfants Malades, Paris, France
    Eur J Immunol 24:2646-52. 1994
    ....
  35. ncbi NF-AT components define a family of transcription factors targeted in T-cell activation
    J P Northrop
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, California 94305
    Nature 369:497-502. 1994
    ..Agents that increase intracellular Ca2+ or activate protein kinase C independently modify NF-ATc, indicating that distinct signalling pathways converge on NF-ATc to regulate its function...
  36. ncbi Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3
    C R Beals
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
    Science 275:1930-4. 1997
    ..Because GSK-3 responds to signals initiated by Wnt and other ligands, NF-AT family members could be effectors of these pathways...
  37. pmc Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells
    Maria Alejandra Alfonso-Jaume
    The Department of Medicine, San Francisco VAMC University of California, 111J Medical Service, 4150 Clement Street, San Francisco, CA 94121, USA
    Biochem J 380:735-47. 2004
    ..Suppression of MT1-MMP by commonly used calcineurin inhibitors may play a role in the development of renal fibrosis following renal transplantation...
  38. ncbi Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells
    S Kinoshita
    Department of Molecular Pharmacology, Stanford University School of Medicine, California 94305, USA
    Cell 95:595-604. 1998
    ..We show that the transcription factor NFATc was sufficient as a cellular factor to induce a highly permissive state for HIV-1 replication in primary CD4+ T ..
  39. ncbi Expression and function of the nuclear factor of activated T cells in colon carcinoma cells: involvement in the regulation of cyclooxygenase-2
    Javier Duque
    Centro de Biologia Molecular Severo Ochoa, Departamento de Biologia Molecular, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    J Biol Chem 280:8686-93. 2005
    ..Here we provide evidence that NFATc1 and NFATc2 are expressed in human colon carcinoma cell lines...
  40. pmc NF-kappaB regulates thrombin-induced ICAM-1 gene expression in cooperation with NFAT by binding to the intronic NF-kappaB site in the ICAM-1 gene
    Jiaping Xue
    Department of Pharmacology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    Physiol Genomics 38:42-53. 2009
    ..Here we show that PAR-1 activation induces binding of both p65/RelA and NFATc1 to the NF-kappaB binding site localized in intron-1 of the ICAM-1 gene to initiate transcription in endothelial ..
  41. ncbi T-cell activation leads to poor activation of the HIV-1 clade E long terminal repeat and weak association of nuclear factor-kappaB and NFAT with its enhancer region
    Anne Marie Lemieux
    Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Quebec, Pavillon CHUL, 2705 Blvd Laurier, Sainte Foy, Quebec G1V 4G2, Canada
    J Biol Chem 279:52949-60. 2004
    ....
  42. pmc Crystal structure of NFAT bound to the HIV-1 LTR tandem kappaB enhancer element
    Darren L Bates
    Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80309 0215, USA
    Structure 16:684-94. 2008
    ..Our studies provide a basis for further investigating the functional mechanisms of NFAT in HIV-1 transcription and replication...
  43. ncbi Induction of DC-STAMP by alternative activation and downstream signaling mechanisms
    Mitsuru Yagi
    Department of Cell Differentiation, The Sakaguchi Laboratory, Keio University School of Medicine, Tokyo, Japan
    J Bone Miner Res 22:992-1001. 2007
    ..Here, we show that dc-stamp expression and cell-cell fusion are regulated in a cell type-specific manner...
  44. pmc Effects on osteoclast and osteoblast activities in cultured mouse calvarial bones by synovial fluids from patients with a loose joint prosthesis and from osteoarthritis patients
    Martin K Andersson
    Department of Orthopaedic Surgery, Karolinska Hospital, Karolinska Institute, 171 76, Stockholm, Sweden
    Arthritis Res Ther 9:R18. 2007
    ..The mRNA expressions of nfat2 (nuclear factor of activated T cells 2) and oscar (osteoclast-associated receptor) were enhanced only by SFs from ..
  45. ncbi RANK ligand signaling modulates the matrix metalloproteinase-9 gene expression during osteoclast differentiation
    Kumaran Sundaram
    Charles P Darby Children s Research Institute, 173 Ashley Avenue, Charleston, SC 29425, USA
    Exp Cell Res 313:168-78. 2007
    ..identified the presence of binding motif (-1123 bp to -1153 bp) for the nuclear factor of activated T cells 1 (NFATc1) transcription factor...
  46. ncbi TRAF2 is essential for TNF-alpha-induced osteoclastogenesis
    Kiyoshi Kanazawa
    Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan
    J Bone Miner Res 20:840-7. 2005
    ..Using this system, we showed that TRAF2 is required for TNF-alpha-induced osteoclastogenesis...
  47. doi Activation of peroxisome proliferator-activated receptor gamma inhibits TNF-alpha-mediated osteoclast differentiation in human peripheral monocytes in part via suppression of monocyte chemoattractant protein-1 expression
    Hiroyuki Hounoki
    Department of Internal Medicine 1, Faculty of Medicine, University of Toyama, Sugitani 2630, Toyama 930 0194, Japan
    Bone 42:765-74. 2008
    ..both agonists inhibited the protein and gene expressions of nuclear factor of activated T-cell isoform c1 (NFATc1), c-Fos, c-Jun and NF-kappaB p65, which are known to be associated with osteoclastogenesis...
  48. ncbi Evidence that calcineurin is required for the genesis of bone-resorbing osteoclasts
    Li Sun
    Mount Sinai Bone Program and Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Physiol Renal Physiol 292:F285-91. 2007
    ..In addition, the expression of NFATc1, as well as the alternative substrate for calcineurin, IkappaBalpha, was significantly enhanced...
  49. ncbi Mechanistic insight into osteoclast differentiation in osteoimmunology
    Hiroshi Takayanagi
    Department of Cellular Physiological Chemistry, COE Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Graduate School, Tokyo Medical and Dental University, Japan
    J Mol Med (Berl) 83:170-9. 2005
    ..The autoamplification of NFATc1 gene results in the efficient induction of osteoclast-specific genes...
  50. pmc Serum calcium-decreasing factor, caldecrin, inhibits osteoclast differentiation by suppression of NFATc1 activity
    Hiroya Hasegawa
    Division of Biochemistry, Department of Oral Biology and Tissue Engineering, Meikai University, School of Dentistry, 1 1 Keyakidai, Sakado, Saitama 350 0283, Japan
    J Biol Chem 285:25448-57. 2010
    ..Caldecrin inhibited accumulation of the RANKL-stimulated nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) mRNA in bone marrow cells, which is a key transcription factor for the differentiation of osteoclasts...
  51. pmc RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitro
    Shuying Yang
    Department of Cytokine Biology, The Forsyth Institute, Boston, MA 02115, USA
    J Bone Miner Res 22:45-54. 2007
    ..RGS12 may play a critical role in the RANKL-evoked PLCgamma-calcium channels-[Ca(2+)](i) oscillation-NFAT2 pathway.
  52. doi VEGF-A expression in osteoclasts is regulated by NF-kappaB induction of HIF-1alpha
    Diana P Trebec-Reynolds
    Faculty of Medicine, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
    J Cell Biochem 110:343-51. 2010
    ..investigate the mechanism of Vegfa induction, specific inhibitors for the transcription factors NF-kappaB, AP-1, NFATc1, and HIF-1 were used...
  53. doi Phytoestrogens directly inhibit TNF-α-induced bone resorption in RAW264.7 cells by suppressing c-fos-induced NFATc1 expression
    Sahar Karieb
    School of Biomedical and Biological Sciences, University of Plymouth, Plymouth, UK
    J Cell Biochem 112:476-87. 2011
    ..had no effect on caspase 3/7 activity or cell viability they did significantly reduce TNF-α-induced c-fos and NFATc1 expression in an ER dependent manner and also inhibited NFATc1 nuclear translocation...
  54. pmc Interleukin-27 inhibits human osteoclastogenesis by abrogating RANKL-mediated induction of nuclear factor of activated T cells c1 and suppressing proximal RANK signaling
    George D Kalliolias
    Hospital for Special Surgery, New York, NY, USA
    Arthritis Rheum 62:402-13. 2010
    ..This study was undertaken to investigate the effects of IL-27 on human osteoclastogenesis, to determine whether IL-27 can stimulate or attenuate the osteoclast-mediated bone resorption that is a hallmark of RA...
  55. doi Osteoclast precursors acquire sensitivity to breast cancer derived factors early in differentiation
    Yubin Guo
    Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
    Bone 43:386-93. 2008
    ..Expression of key osteoclastogenic transcription factor NFATc1 in osteoclast precursors was dramatically increased by short treatment with RANKL...
  56. doi The mechanism of osteoclast differentiation induced by IL-1
    Jung Ha Kim
    National Research Laboratory for Regulation of Bone Metabolism and Disease, Medical Research Center for Gene Regulation, Brain Korea 21, Chonnam National University Medical School, Gwangju, Korea
    J Immunol 183:1862-70. 2009
    ..The expression of IL-1RI is up-regulated by RANKL via c-Fos and NFATc1. Furthermore, the addition of IL-1 to IL-1RI overexpressing BMMs (IL-1/IL-1RI) strongly activates NF-kappaB, JNK, ..
  57. pmc Interleukin-32 promotes osteoclast differentiation but not osteoclast activation
    Guillaume Mabilleau
    Nuffield Department of Orthopaedic Surgery, University of Oxford, Oxford, UK
    PLoS ONE 4:e4173. 2009
    ..IL-32 has the typical properties of a pro-inflammatory mediator and although its role in rheumatoid arthritis has been recently reported its effect on the osteoclastogenesis process remains unclear...
  58. pmc Modeled microgravity and hindlimb unloading sensitize osteoclast precursors to RANKL-mediated osteoclastogenesis
    Ritu Saxena
    Department of Cancer Biology and Pharmacology, College of Medicine, University of Illinois at Peoria, Peoria, IL 61605, USA
    J Bone Miner Metab 29:111-22. 2011
    ..precursors; however, 24 h of MMG activates osteoclastogenesis-related signaling molecules ERK, p38, PLCγ2, and NFATc1. Receptor activator of NFkB ligand (RANKL) (with or without M-CSF) stimulation for 3-4 days in gravity of cells ..
  59. pmc Intercellular adhesion molecule-1 on synovial cells attenuated interleukin-6-induced inhibition of osteoclastogenesis induced by receptor activator for nuclear factor κB ligand
    M Suzuki
    Product Research Department, Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co Ltd, 1 135 Komakado, Gotemba, Shizuoka, Japan
    Clin Exp Immunol 163:88-95. 2011
    ..tartrate-resistant acid phosphatase isoform 5b (TRAP5b) and nuclear factor of activated T cells cytoplasmic 1 (NFATc1), whereas the co-addition of IL-6 decreased them both in a dose-dependent manner...
  60. ncbi Dysregulation of connexins and inactivation of NFATc1 in the cardiovascular system of Nkx2-5 null mutants
    Laurent Dupays
    Laboratoire de Génétique et Physiologie du Développement UMR CNRS 6545, Institut de Biologie du Developpement de Marseille, Universite de la Mediterranee, 13288 Marseille Cedex 9, France
    J Mol Cell Cardiol 38:787-98. 2005
    ..In addition, the nuclear translocation of NFATc1 in the endocardial endothelial cells is inhibited in the Nkx2-5-/- embryos...
  61. pmc Nuclear factor of activated T cells (NFAT) signaling regulates PTEN expression and intestinal cell differentiation
    Qingding Wang
    Department of Surgery, The University of Kentucky, Lexington, KY 40506, USA
    Mol Biol Cell 22:412-20. 2011
    The nuclear factor of activated T cell (NFAT) proteins are a family of transcription factors (NFATc1-c4) involved in the regulation of cell differentiation and adaptation...
  62. pmc Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival
    Danielle M Lapierre
    Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London N6A 5C1, Ontario, Canada
    J Biol Chem 285:25792-801. 2010
    ..LPA induced nuclear translocation of NFATc1 and enhanced osteoclast survival, effects that were blocked by VPC-32183 or by a specific peptide inhibitor of ..
  63. doi T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    Bone 45:627-39. 2009
    ..We examined the effect of the peptide on the expression of both mRNA and protein of NFATc1. We also examined the effect of RANKL on the expression of mRNA of the molecule on osteoclasts and macrophages...
  64. pmc Specificity of RGS10A as a key component in the RANKL signaling mechanism for osteoclast differentiation
    Shuying Yang
    Department of Cytokine Biology, The Forsyth Institute, Boston, MA 02115, USA
    J Cell Sci 120:3362-71. 2007
    ..RGS10A silencing by RNA interference blocked intracellular [Ca2+]i oscillations, the expression of NFAT2, and osteoclast terminal differentiation in both bone marrow cells and osteoclast precursor cell lines...
  65. doi The Rho GTPase Wrch1 regulates osteoclast precursor adhesion and migration
    Hélène Brazier
    Centre de Recherche de Biochimie Macromoleculaire, Montpellier University, CNRS, UMR 5237, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    Int J Biochem Cell Biol 41:1391-401. 2009
    ..Suppression of Wrch1 did not prevent induction of classical osteoclastic markers such as NFATc1, Src, TRAP (Tartrate-Resistant Acid Phosphatase) or cathepsin K...
  66. pmc Transforming growth factor beta blocks Tec kinase phosphorylation, Ca2+ influx, and NFATc translocation causing inhibition of T cell differentiation
    Chang Hung Chen
    Vion Pharmaceuticals, Incorporated, New Haven, CT 06511, USA
    J Exp Med 197:1689-99. 2003
    ..Calcium influx in activated T cells and the subsequent activation of transcription factors such as NFATc, events essential for T cell differentiation, are modulated by the Tec kinases that are downstream of the T cell ..
  67. ncbi Embryonic heart failure in NFATc1-/- mice: novel mechanistic insights from in utero ultrasound biomicroscopy
    Colin K L Phoon
    Pediatric Cardiology Program, New York University School of Medicine, New York, NY, USA
    Circ Res 95:92-9. 2004
    ..Using in utero ultrasound biomicroscopy (UBM), we studied embryonic day (E) 10.5 to 14.5 NFATc1-/- embryos and control littermates...
  68. ncbi Cardiac outflow tract: a review of some embryogenetic aspects of the conotruncal region of the heart
    Angelo Restivo
    Pediatric Cardiology, Department of Pediatrics, University of Rome La Sapienza, Viale Regina Elena 324, 00161 Rome, Italy
    Anat Rec A Discov Mol Cell Evol Biol 288:936-43. 2006
    ....
  69. ncbi SH3BP2 is rarely mutated in exon 9 in giant cell lesions outside cherubism
    Steven A Lietman
    Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH 44195, USA
    Clin Orthop Relat Res 459:22-7. 2007
    ..therefore hypothesized SH3BP2 and its putative downstream effector nuclear factor of activated T cells c1 isoform (NFATc1) are highly expressed in sporadic nonsyndromic giant cell lesions and associated with somatic SH3BP2 mutations...
  70. ncbi Mechanisms of Ca2+-dependent calcineurin activation in mechanical stretch-induced hypertrophy
    Carsten Zobel
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Cologne, Germany
    Cardiology 107:281-90. 2007
    ..Stretch increased the calcineurin activity, MCIP1 gene expression and DNA binding of NFATc as well as the protein/DNA ratio and ANP mRNA in a significant manner...
  71. doi Calcineurin-NFAT signaling is involved in phenylephrine-induced vascular smooth muscle cell proliferation
    Xiao Pang
    Department of Cardiology, People s Hospital, Peking University, Beijing, China
    Acta Pharmacol Sin 30:537-44. 2009
    ..The calcineurin-NFAT pathway plays a role in regulating growth and differentiation in various cell types. We investigated whether the calcineurin-NFAT pathway was involved in the regulation of phenylephrine-induced VSMC proliferation...
  72. doi The small molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells
    Hiroshi Egusa
    Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Bone 49:264-74. 2011
    ..assay demonstrated that harmine directly inhibited the DYRK1A-mediated phosphorylation (in-activation) of NFATc1. Harmine promoted the dephosphorylation (activation) of NFATc1 in RAW264...
  73. pmc Mechanism of nuclear factor of activated T-cells mediated FasL expression in corticosterone -treated mouse Leydig tumor cells
    Wei Ran Chai
    Department of Biochemistry and Molecular Biology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, PR China
    BMC Cell Biol 9:31. 2008
    ..It is not clear yet how NFAT is involved in CORT-induced up-regulation of FasL. The aim of the present study is to investigate the molecular mechanisms of NFAT-mediated FasL expression in CORT-treated Leydig cells...
  74. ncbi CCR1 acts downstream of NFAT2 in osteoclastogenesis and enhances cell migration
    Norihiro Ishida
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    J Bone Miner Res 21:48-57. 2006
    We found that a chemokine receptor gene, CCR1, acts downstream of NFAT2 in RANKL-stimulated RAW264 and bone marrow cells. The upstream regulatory region of CCR1 showed RANKL-dependent and CsA-suppressible promoter activity...
  75. doi CD5 promotes IL-10 production in chronic lymphocytic leukemia B cells through STAT3 and NFAT2 activation
    Soizic Garaud
    EA2216 Immunology and Pathology, IFR 148 ScInBioS, European University of Brittany, F29609 Brest, France
    J Immunol 186:4835-44. 2011
    ..STAT3 is activated via phosphorylation of serine 727 but also NFAT2 through its translocation into the nucleus...
  76. ncbi DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice
    Alexander W Lange
    Division of Molecular Cardiovascular Biology, Children s Medical Center Cincinnati ML 7020, Cincinnati, OH 45229, USA
    Dev Biol 266:346-60. 2004
    ..DSCR1(e4)/lacZ expression in the developing valve endocardium colocalizes with NFATc1 and, endocardial DSCR1(e4)/lacZ, is notably reduced or absent in NFATc1(-/-) embryos...
  77. pmc Complex regulation of tartrate-resistant acid phosphatase (TRAP) expression by interleukin 4 (IL-4): IL-4 indirectly suppresses receptor activator of NF-kappaB ligand (RANKL)-mediated TRAP expression but modestly induces its expression directly
    Minjun Yu
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 284:32968-79. 2009
    ..STAT6VT did not inhibit the potent up-regulation of TRAP promoter activity caused by overexpression of NFATc1, PU...
  78. ncbi Activation of the beta myosin heavy chain promoter by MEF-2D, MyoD, p300, and the calcineurin/NFATc1 pathway
    Joachim D Meissner
    Department of Physiology, Hannover Medical School, Hannover, Germany
    J Cell Physiol 211:138-48. 2007
    ..Transient transfection assays demonstrated that the calcineurin/NFATc1 signaling pathway is essential for MyHCbeta promoter activation during transformation of C2C12 myotubes but is not ..
  79. pmc Activation of alpha(1) -adrenergic receptors stimulate the growth of small mouse cholangiocytes via calcium-dependent activation of nuclear factor of activated T cells 2 and specificity protein 1
    Gianfranco Alpini
    Central Texas Veterans Health Care System, TX, USA
    Hepatology 53:628-39. 2011
    ..The Ca(2+) -dependent transcription factors, nuclear factor of activated T cells 2 (NFAT2) and NFAT4, were predominantly expressed by small bile ducts and small cholangiocytes...
  80. pmc Resolution of established cardiac hypertrophy and fibrosis and prevention of systolic dysfunction in a transgenic rabbit model of human cardiomyopathy through thiol-sensitive mechanisms
    Raffaella Lombardi
    Center for Cardiovascular Genetics, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, and Texas Heart Institute, Houston, TX, USA
    Circulation 119:1398-407. 2009
    ..We posit that treatment with N-acetylcysteine, a precursor of glutathione, the largest intracellular thiol pool against oxidative stress, could reverse cardiac hypertrophy and fibrosis in HCM...
  81. ncbi Inhibition of the calcineurin-NFAT interaction by small organic molecules reflects binding at an allosteric site
    Sunghyun Kang
    CBR Institute for Biomedical Research, Boston, MA 02115, USA
    J Biol Chem 280:37698-706. 2005
    ..phosphatase calcineurin to its substrate NFAT (nuclear factor of activated T cells, also termed NFATc) is critically dependent on a protein-protein docking interaction between calcineurin and the PXIXIT motif in NFAT...
  82. ncbi The Trypanosoma cruzi immunosuppressive factor (TIF) targets a lymphocyte activation event subsequent to increased intracellular calcium ion concentration and translocation of protein kinase C but previous to cyclin D2 and cdk4 mRNA accumulation
    F Kierszenbaum
    Department of Microbiology, Michigan State University, East Lansing 48824, USA
    Mol Biochem Parasitol 92:133-45. 1998
    ..stimulated with phytohemagglutinin from accumulating normal mRNA levels of NFAT1 (also known as NFATp) and NFATc. NFAT1 and NFATc are components of the NFAT complex that controls transcription of genes coding for several ..
  83. pmc Activation and expression of the nuclear factors of activated T cells, NFATp and NFATc, in human natural killer cells: regulation upon CD16 ligand binding
    J Aramburu
    Department of Microbiology and Immunology, Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Exp Med 182:801-10. 1995
    ..Two distinct molecules, NFATp and NFATc, have been reported to mediate NFAT activity...
  84. ncbi Characterization of Nfatc1 regulation identifies an enhancer required for gene expression that is specific to pro-valve endocardial cells in the developing heart
    Bin Zhou
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Development 132:1137-46. 2005
    b>Nfatc1 is an endocardial transcription factor required for development of cardiac valves...
  85. doi Glycogen synthase kinase 3beta regulation of nuclear factor of activated T-cells isoform c1 in the vascular smooth muscle cell response to injury
    Winsion Chow
    Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 Kings College Circle, Rm 6213, Toronto, Ontario, Canada M5S 1A8
    Exp Cell Res 314:2919-29. 2008
    ..The transcription factor nuclear factor of activated T-cells-isoform c1 (NFATc1) is regulated by atherogenic cytokines, and has been implicated in the migratory and proliferative responses of ..
  86. ncbi The molecular understanding of osteoclast differentiation
    Masataka Asagiri
    Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Yushima 1 5 45, Tokyo 113 8549, Japan
    Bone 40:251-64. 2007
    ..TRAF6 activates NF-kappaB, which is important for the initial induction of NFATc1. NFATc1 is activated by calcium signaling and binds to its own promoter, thus switching on an autoregulatory loop...
  87. ncbi Characterization of constitutive and inducible transcription factors binding to the P2 NF-AT site in the human interleukin-4 promoter
    M Li-Weber
    Tumor Immunology Program, German Cancer Research Center, Heidelberg
    Gene 188:253-60. 1997
    ..Therefore, the DNA sequence at -173 to -150 of the IL-4 promoter is a binding site for NF-ATp/c and AP-1. Octamer proteins are unlikely to cooperate with NF-ATp/c at this site...
  88. doi Trichostatin A inhibits osteoclastogenesis and bone resorption by suppressing the induction of c-Fos by RANKL
    Ha Neui Kim
    Department of Cell and Developmental Biology, DRI, School of Dentistry, Seoul National University, 28 Yeongon dong, Jongno gu, Seoul 110 749, Republic of Korea
    Eur J Pharmacol 623:22-9. 2009
    ..This effect was accompanied by a significant decrease in the RANKL-stimulated induction of c-Fos and NFATc1, which are key transcription factors during early osteoclastogenesis...
  89. ncbi Stimulation of calcineurin signaling attenuates the dystrophic pathology in mdx mice
    Joe V Chakkalakal
    Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Hum Mol Genet 13:379-88. 2004
    ..Muscles from mdx/CnA* displayed increased nuclear localization of NFATc1 and a fiber type shift towards a slower phenotype...
  90. ncbi Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc
    A M Ranger
    Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Immunity 8:125-34. 1998
    ..Our data demonstrate that NF-ATc is essential for the optimal generation and function of mature T and B lineage cells, with an especially profound effect on IL-4-driven responses...
  91. ncbi Inhibition of osteoclast differentiation and bone resorption by sauchinone
    Kyoung Youn Han
    Department of Cell and Developmental Biology, BK21 Program, and DRI, Seoul National University, Seoul 110 749, Republic of Korea
    Biochem Pharmacol 74:911-23. 2007
    ..The RANKL-stimulated induction of c-Fos and NFATc1 transcription factors was also abrogated by sauchinone...
  92. doi Identification of NFAT binding sites that mediate stimulation of cathepsin K promoter activity by RANK ligand
    Wayne Balkan
    Geriatrics Research, Education and Clinical Center and Research Service, Miami Veterans Affairs Healthcare System, Miami, FL 33125, USA
    Gene 446:90-8. 2009
    ..RANKL acts, in part, via the Ca(2+)/calmodulin/calcineurin signaling pathway, which in turn, activates NFATc1 (nuclear factor of activated T-cells) and downstream gene expression...
  93. ncbi NFAT2 is implicated in corticosterone-induced rat Leydig cell apoptosis
    Wei Ran Chai
    Department of Biochemistry and Molecular Biology, School of Medicine Shanghai Jiaotong University, Shanghai 200025, China
    Asian J Androl 9:623-33. 2007
    ..To investigate the activation of the nuclear factor of activated T cells (NFAT) and its function in the corticosterone (CORT)-induced apoptosis of rat Leydig cells...
  94. pmc Interleukin-10 inhibits osteoclastogenesis by reducing NFATc1 expression and preventing its translocation to the nucleus
    Kathryn E Evans
    Ecotoxicology and Stress Biology Research Group, School of Biological Science, University of Plymouth, UK
    BMC Cell Biol 8:4. 2007
    ..Several major pathways regulate osteoclastogenesis, with key signalling genes such as p38, TRAF6, NF-kappaB and NFATc1 well established as playing vital roles...
  95. pmc Simvastatin stimulates production of the antiapoptotic protein Bcl-2 via endothelin-1 and NFATc3 in SH-SY5Y cells
    Tammy A Butterick
    Department of Pharmacology, Geriatric Research Education and Clinical Center, VA Medical Center, University of Minnesota, Minneapolis, MN, USA
    Mol Neurobiol 41:384-91. 2010
    ..Simvastatin increased translocation of NFATc3 to the nucleus while reducing nuclear NFATc1 and having no effect on NFATc4...
  96. ncbi The calcineurin-NFAT pathway and muscle fiber-type gene expression
    S J Swoap
    Department of Biology, Williams College, Williamstown, Massachusetts 01267, USA
    Am J Physiol Cell Physiol 279:C915-24. 2000
    ..promoters were examined in C2C12 myotubes and in slow and fast muscle in the presence of calcineurin or NFAT2 expression plasmids...
  97. ncbi Calcineurin is a potent regulator for skeletal muscle regeneration by association with NFATc1 and GATA-2
    Kunihiro Sakuma
    Department of Legal Medicine, Kyoto Prefectural University of Medicine, 456 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Japan
    Acta Neuropathol 105:271-80. 2003
    ..The amount of calcineurin and dephosphorylated nuclear factor of activated T cells c1 (NFATc1) proteins was markedly increased in the regenerating muscle of rats...
  98. pmc DNA binding sites target nuclear NFATc1 to heterochromatin regions in adult skeletal muscle fibers
    Tiansheng Shen
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, MD 21201 1503, USA
    Histochem Cell Biol 134:387-402. 2010
    ..dephosphorylation of the transcription factor nuclear factor of activated T cells subtype 1 (NFATc1) during repetitive skeletal muscle activity causes NFAT nuclear translocation and concentration in subnuclear NFAT ..
  99. pmc NFATc1 mediates HDAC-dependent transcriptional repression of osteocalcin expression during osteoblast differentiation
    Min Kyung Choo
    Department of Pathology, University of Alabama at Birmingham, 813 Shelby Biomedical Research Building, 1825 University Boulevard, Birmingham, AL 35294, USA
    Bone 45:579-89. 2009
    ..To investigate the mechanism by which NFATc1 regulates osteoblast differentiation, we established an osteoblast cell line that overexpresses a constitutively ..
  100. pmc NFAT signalling is a novel target of oncogenic BRAF in metastatic melanoma
    R J Flockhart
    Dermatological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Br J Cancer 101:1448-55. 2009
    ....

Research Grants91

  1. TRAF6 E3 LIGASE FUNCTION IN OSTEOCLASTOGENESIS
    Bryant Darnay; Fiscal Year: 2007
    ..endogenous TRAF6 is auto-ubiquitinated via K63 linkages, which is critical for NF-(B activation, induction of NFATc1 and subsequent osteoclast differentiation...
  2. Role of Twisted Gastrulation in Osteoclastogenesis
    Rajaram Gopalakrishnan; Fiscal Year: 2010
    ..associated with an increase in cell fusion and upregulation of key genes involved in osteoclast differentiation (NFATc1) and cell- cell fusion (DC-STAMP)...
  3. TRAF6 E3 LIGASE FUNCTION IN OSTEOCLASTOGENESIS
    Bryant G Darnay; Fiscal Year: 2010
    ..endogenous TRAF6 is auto-ubiquitinated via K63 linkages, which is critical for NF-(B activation, induction of NFATc1 and subsequent osteoclast differentiation...
  4. Regulatory mechanisms in osteoclasts
    Yongwon Choi; Fiscal Year: 2010
    ..Finally, by examining Atp6v0d2 expression, we show that NFATc1 may regulate cell-cell fusion between preosteoclasts, in part, by regulating the induction of Atp6v0d2 expression, ..
  5. Mi: Modulating Osteoclast Gene Expression and Function
    Michael C Ostrowski; Fiscal Year: 2010
    ..Subsequent to these events, the transcription factor NFATc1 is recruited to the target promoters. This data leads to our overall hypothesis: MITF/PU...
  6. Mi: Modulating Osteoclast Gene Expression and Function
    Michael Ostrowski; Fiscal Year: 2009
    ..Subsequent to these events, the transcription factor NFATc1 is recruited to the target promoters. This data leads to our overall hypothesis: MITF/PU...
  7. STUDIES OF THE FATE OF THE OSTEOCLAST
    BRENDAN BOYCE; Fiscal Year: 2009
    ..formation both directly and indirectly through RANKL and three sets of transcription factors: NF-?B; c-Fos; and NFATc1. Expression of these is essential for osteoclast formation...
  8. STUDIES OF THE FATE OF THE OSTEOCLAST
    Brendan F Boyce; Fiscal Year: 2010
    ..formation both directly and indirectly through RANKL and three sets of transcription factors: NF-?B;c-Fos;and NFATc1. Expression of these is essential for osteoclast formation...
  9. RANK Signaling in Osteoclast Differentiation and Function
    Xu Feng; Fiscal Year: 2010
    ..RANKL has been shown to activate six major signaling pathways: NF-kappa B, JNK, ERK, p38, NFATc1 and AKT...
  10. RANK Signaling in Osteoclast Differentiation and Function
    Xu Feng; Fiscal Year: 2007
    ..RANKL has been shown to activate six major signaling pathways: NF-kappa B, JNK, ERK, p38, NFATc1 and AKT...
  11. RANK Signaling in Osteoclast Differentiation and Function
    Xu Feng; Fiscal Year: 2009
    ..RANKL has been shown to activate six major signaling pathways: NF-kappa B, JNK, ERK, p38, NFATc1 and AKT...
  12. The Role of AML1 in Osteoclastogenesis and Osteoclast Gene Expression
    Yi Ping Li; Fiscal Year: 2010
    ..Despite the recent insights gained from the effects of targeted deletion of the c-fos, PU.1, NF-B, and NFATc1 transcription factor genes, the mechanism underlying transcription factors specifying osteoclast (OC) lino define ..
  13. The Role of NFATc1 and Calcineurin in Bone Remodeling
    Mone Zaidi; Fiscal Year: 2007
    ..We also find that RANK-L stimulates the expression and nuclear import of calcineurin's primary substrate, NFATc1. Likewise, Ca2+ triggers NFATc1 import, stimulates osteoclast formation, and inhibits the transcription of an anti-..
  14. Role of Calcineurin/NFAT signaling in the pathogenesis of neurodegeneration in Do
    Isabella A Graef; Fiscal Year: 2010
    ..We will use mouse models to investigate whether changes in CaN activity and/or CaN activated NFATc-dependent transcription can alter the phosphorylation of tau and APP, the processing of APP or the response of ..
  15. Role of RGS10 in Osteoclast Differentiation
    Yi Ping Li; Fiscal Year: 2010
    ..However, how RANKL signal evokes [Ca2+]i oscillation that lead osteoclast differentiation thought NFAT2 pathway still remain unclear...
  16. Role of RGS10 in Osteoclast Differentiation
    Yi Ping Li; Fiscal Year: 2007
    ..However, how RANKL signal evokes [Ca2+]i oscillation that lead osteoclast differentiation thought NFAT2 pathway still remain unclear...
  17. STUDIES OF THE FATE OF THE OSTEOCLAST
    BRENDAN BOYCE; Fiscal Year: 2007
    ..production of M-CSF and RANKL, which bind to their receptors on osteoclasts and activate c-Fos/AP-1, NFkappaB, and NFAT2, expression of each of which is required for osteoclast formation...
  18. REGULATING GLI FUNCTION IN HAIR FOLLICLE PROGENITORS
    ANTHONY ORO; Fiscal Year: 2009
    ..that calcium transients via the voltage gated calcium channels regulate hair stem cell quiescence through Nfatc1 regulation...
  19. HTS Assay Development for Modulators of a Nuclear Import/Export Switch
    ISABELLA GRAEF; Fiscal Year: 2007
    ..we have recently shown that many biologic processes are exquisitely sensitive to the level of nuclear occupancy of NFATc proteins...
  20. ATF4 and Osteoclastogenesis
    Guozhi Xiao; Fiscal Year: 2010
    ..Furthermore, ATF4 directs RANKL-dependent gene expression of NFATc1, a master regulator of OCL differentiation...
  21. NFAT SIGNALING IN GLOMERULOSCLEROSIS
    Feng Chen; Fiscal Year: 2010
    ..We have generated a murine model in which inducible podocyte-specific NFATc1 activation leads to FSGS, providing the first in vivo proof of the involvement of NFAT signaling in FSGS...
  22. Mechanobiological Mechanism for Inflammatory Bone Loss
    Francis Young In Lee; Fiscal Year: 2010
    ..particles and mechanical perturbation enhance RANKL-supported osteoclastogenesis by co-activating the calcineurin/NFATc1/TNF-a axis in macrophages, and 3) To determine the combinatorial effect of UHMWPE wear particles and mechanical ..
  23. Mechanobiological Mechanism for Inflammatory Bone Loss
    Francis Lee; Fiscal Year: 2007
    ..particles and mechanical perturbation enhance RANKL-supported osteoclastogenesis by co-activating the calcineurin/NFATc1/TNF-a axis in macrophages, and 3) To determine the combinatorial effect of UHMWPE wear particles and mechanical ..
  24. Functional Studies of Calmyrin
    MERVYN MONTEIRO; Fiscal Year: 2007
    ..results in a dramatic alteration in calmitase localization in the nucleus and stimulates nuclear import of an NFATc-GFP reporter...
  25. Functional Studies of Calmyrin
    MERVYN MONTEIRO; Fiscal Year: 2009
    ..results in a dramatic alteration in calmitase localization in the nucleus and stimulates nuclear import of an NFATc-GFP reporter...
  26. Signaling in T Lymphocyte Development
    Gerald Crabtree; Fiscal Year: 2007
    ..also define the processes downstream of calcineurin that mediate positive selection including the mechanism of NFATc nuclear import and export, the set of genes that are dependent on calcineurin activity in positive selection and ..
  27. Molecular Mechanisms in Bone Resorption
    STEVEN LIETMAN; Fiscal Year: 2009
    ..b>NFATc1 (also termed NFAT2) is the master switch of osteoclastogenesis...
  28. Molecular Mechanisms in Bone Resorption
    Steven A Lietman; Fiscal Year: 2010
    ..b>NFATc1 (also termed NFAT2) is the master switch of osteoclastogenesis...
  29. Regulation of Facultative Islet Growth and Development by Calcineurin and NFAT
    Seung K Kim; Fiscal Year: 2010
    ..Mice lacking beta-cell calcineurin function develop overt diabetes. Strikingly, expression of activated NFATc1 in beta-cells lacking calcineurin restores beta-cell growth and prevents diabetes...
  30. Regulation of Facultative Islet Growth and Development by Calcineurin and NFAT
    Seung K Kim; Fiscal Year: 2010
    ..Mice lacking beta-cell calcineurin function develop overt diabetes. Strikingly, expression of activated NFATc1 in beta-cells lacking calcineurin restores beta-cell growth and prevents diabetes...
  31. Regulation of Facultative Islet Growth and Development by Calcineurin and NFAT
    Seung Kim; Fiscal Year: 2007
    ..Mice lacking beta-cell calcineurin function develop overt diabetes. Strikingly, expression of activated NFATc1 in beta-cells lacking calcineurin restores beta-cell growth and prevents diabetes...
  32. NFAT Signaling and Down Syndrome
    Gerald R Crabtree; Fiscal Year: 2010
    ..Remarkably, the phenotypes of NFATc1, c2, c3 and c4 mutant mice reproduce severe forms of many or most of the characteristic features of Down syndrome...
  33. ENDOSTEAL BONE VOLUME REGULATION AND OSTEOPOROSIS
    Subburaman Mohan; Fiscal Year: 2010
    ..mediated in part via Cldn-18 interaction with a PDZ domain containing protein, Zona Occluden-2 (ZO-2), to modulate NFATc1 regulation of RANKL target genes...
  34. Skin Stem Cells: Purification and Characterization
    Elaine Fuchs; Fiscal Year: 2009
    ..We showed that HF-SCs express a group of transcription factors-- Sox9, Lhx2, NFATc1 & Tcf3/4--which basal IFE SCs do not, and we used these markers to trace the origins of HF-SCs to ..
  35. Skin Stem Cells: Purification and Characterization
    Elaine Fuchs; Fiscal Year: 2010
    ..We showed that HF-SCs express a group of transcription factors-- Sox9, Lhx2, NFATc1 &Tcf3/4--which basal IFE SCs do not, and we used these markers to trace the origins of HF-SCs to embryogenesis...
  36. Structure and Function of Ocular Lacritin
    GORDON LAURIE; Fiscal Year: 2007
    ..we then determined that lacritin signals from Ga1, or Ga0 to PLC-PKCa/PLD/mTOR and PLCPKCa/ STIM1/calcineurin/Ca2+/NFATC1 to activate secretory and mitogenic responses...
  37. Neurofibromin, Ras & NFAT in Cardiovascular Development
    FRAZ ISMAT; Fiscal Year: 2007
    ..through the ras-GAP function of neurofibromin and its effect on nuclear localization of the transcription factor NFATc1 (nuclear factor of activated T-cells)...
  38. Structure and Function of Ocular Lacritin
    GORDON WILLIAM LAURIE; Fiscal Year: 2010
    ..coupled receptor for signaling through G1i or G1o to PLC-PKC1/PLD/mTOR and PLC- PKC1/STIM1/calcineurin/Ca2+/ NFATC1. Differential upregulation of newly identified splice variants lacritin-b or -c (suspected to be incapable of ..
  39. Structure and Function of Ocular Lacritin
    GORDON LAURIE; Fiscal Year: 2009
    ..coupled receptor for signaling through G1i or G1o to PLC-PKC1/PLD/mTOR and PLC- PKC1/STIM1/calcineurin/Ca2+/ NFATC1. Differential upregulation of newly identified splice variants lacritin-b or -c (suspected to be incapable of ..
  40. MSX2-Wnt Signaling in Cardiovascular Calcification
    Dwight A Towler; Fiscal Year: 2010
    ..LRP6 mediates Wnt7-dependent osteogenic and fibrotic signals in culture via 2-catenin and NFATc-mediated transcription...
  41. Molecular and Cellular Pathogenesis of Cherubism
    Yasuyoshi Ueki; Fiscal Year: 2010
    ..data suggest that ERK and MyD88 are involved in TNF- 1 production by hyperactive macrophages, while Syk and NFATc1 are involved in osteoclast hyperactivation...
  42. Increased HIV-1 Transcription in T-helper 2 Cells
    RANDALL CRON; Fiscal Year: 2007
    ..Based on our in vitro binding data, we hypothesize that NFAT2 preferentially binds the HIV-1 LTR in vivo and augments HIV-1 transcription...
  43. RHOA EFFECTOR IN HIV-1 REPLICATION AND PATHOGENESIS
    Lishan Su; Fiscal Year: 2004
    ..In addition, we showed that RhoA inhibited HIV gene expression. The NFATc/AP2 binding site and sequences in the Negative Regulatory Element (NRE) region of HIV Long Terminal Repeat (LTR) ..
  44. NEUROFIBROMIN, NEURAL CREST AND CARDIAC DEVELOPMENT
    Jonathan Epstein; Fiscal Year: 2007
    ..We also demonstrate enhanced nuclear localization of NFATc1 (a factor known to be required for endocardial cushion formation) in Nf1-null endocardium...
  45. REGULATORY PATHWAYS IN OSTEOCLAST FORMATION AND FUNCTION
    Roberta Faccio; Fiscal Year: 2009
    ..precursors fail to differentiate due to defective activation of AP1 and NFkappaB and a failure in upregulation of NFATc1, a master transcription actor for osteoclastogenesis...