NF2

Summary

Gene Symbol: NF2
Description: neurofibromin 2
Alias: ACN, BANF, SCH, merlin, moesin-ezrin-radixin like, moesin-ezrin-radixin-like protein, moesin-ezrin-radizin-like protein, neurofibromin 2 (bilateral acoustic neuroma), schwannomerlin, schwannomin
Species: human
Products:     NF2

Top Publications

  1. Papi L, De Vitis L, Vitelli F, Ammannati F, Mennonna P, Montali E, et al. Somatic mutations in the neurofibromatosis type 2 gene in sporadic meningiomas. Hum Genet. 1995;95:347-51 pubmed
    ..usually sporadic, they can occur in patients affected by the autosomal dominant syndrome, neurofibromatosis type 2 (NF2). The NF2 gene has recently been isolated from chromosome 22...
  2. Rouleau G, Merel P, Lutchman M, Sanson M, Zucman J, Marineau C, et al. Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2. Nature. 1993;363:515-21 pubmed
    Neurofibromatosis type 2 (NF2) is a monogenic dominantly inherited disease predisposing carriers to develop nervous system tumours...
  3. Jacoby L, MacCollin M, Louis D, Mohney T, Rubio M, Pulaski K, et al. Exon scanning for mutation of the NF2 gene in schwannomas. Hum Mol Genet. 1994;3:413-9 pubmed
    ..Recently, the gene encoding merlin, a novel member of a family of cytoskeleton-associated proteins, was identified as the NF2 tumor suppressor...
  4. Laulajainen M, Muranen T, Carpen O, Grönholm M. Protein kinase A-mediated phosphorylation of the NF2 tumor suppressor protein merlin at serine 10 affects the actin cytoskeleton. Oncogene. 2008;27:3233-43 pubmed
    Mutations in the neurofibromatosis 2 tumor suppressor gene (NF2) encoding merlin (moesin-ezrin-radixin like-protein) induce tumors of the nervous system...
  5. Schulz A, Baader S, Niwa Kawakita M, Jung M, Bauer R, Garcia C, et al. Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy. Nat Neurosci. 2013;16:426-33 pubmed publisher
    ..type 2 (NF2) is a hereditary tumor syndrome caused by inactivation of the NF2 tumor suppressor gene, encoding merlin. Apart from tumors affecting the peripheral and central nervous systems, most NF2 patients develop peripheral ..
  6. Szijan I, Rochefort D, Bruder C, Surace E, Machiavelli G, Dalamon V, et al. NF2 tumor suppressor gene: a comprehensive and efficient detection of somatic mutations by denaturing HPLC and microarray-CGH. Neuromolecular Med. 2003;3:41-52 pubmed
    The NF2 tumor suppressor gene, located in chromosome 22q12, is involved in the development of multiple tumors of the nervous system, either associated with neurofibromatosis 2 or sporadic ones, mainly schwannomas and meningiomas...
  7. Heinrich B, Hartmann C, Stemmer Rachamimov A, Louis D, MacCollin M. Multiple meningiomas: Investigating the molecular basis of sporadic and familial forms. Int J Cancer. 2003;103:483-8 pubmed
    ..The only genes known to be associated with sporadic meningiomas are NF2 on chromosome 22 and the related cytoskeleton element DAL-1 on chromosome 18...
  8. Jin H, Sperka T, Herrlich P, Morrison H. Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase. Nature. 2006;442:576-9 pubmed
    The tumour suppressor protein merlin (encoded by the neurofibromatosis type 2 gene NF2) is an important regulator of proliferation in many cell and tissue types...
  9. Goutebroze L, Brault E, Muchardt C, Camonis J, Thomas G. Cloning and characterization of SCHIP-1, a novel protein interacting specifically with spliced isoforms and naturally occurring mutant NF2 proteins. Mol Cell Biol. 2000;20:1699-712 pubmed
    The neurofibromatosis type 2 (NF2) protein, known as schwannomin or merlin, is a tumor suppressor involved in NF2-associated and sporadic schwannomas and meningiomas...

More Information

Publications66

  1. Tang X, Jang S, Wang X, Liu Z, Bahr S, Sun S, et al. Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation. Nat Cell Biol. 2007;9:1199-207 pubmed
    The neurofibromatosis-2 (NF2) tumour-suppressor gene encodes an intracellular membrane-associated protein, called merlin, whose growth-suppressive function is dependent on its ability to form interactions through its intramolecular amino-..
  2. Flaiz C, Ammoun S, Biebl A, Hanemann C. Altered adhesive structures and their relation to RhoGTPase activation in merlin-deficient Schwannoma. Brain Pathol. 2009;19:27-38 pubmed publisher
    ..system that occur spontaneously and in patients with neurofibromatosis 2 (NF2) and lack the tumor suppressor merlin. Merlin is known to bind paxillin, beta1 integrin and focal adhesion kinase, members of focal contacts, multi-..
  3. Thurneysen C, Opitz I, Kurtz S, Weder W, Stahel R, Felley Bosco E. Functional inactivation of NF2/merlin in human mesothelioma. Lung Cancer. 2009;64:140-7 pubmed publisher
    The tumor suppressor merlin is encoded by the neurofibromatosis type 2 gene (NF2) which is located on chromosome 22q12 and mutations in this gene have been found in 40% of mesothelioma...
  4. Kluwe L, Mautner V. A missense mutation in the NF2 gene results in moderate and mild clinical phenotypes of neurofibromatosis type 2. Hum Genet. 1996;97:224-7 pubmed
    Since the identification of the NF2 tumor suppressor gene in 1993, various mutations have been found in NF2-related tumors and in lymphocytes from NF2 patients. Most of the reported mutations result in truncated gene products...
  5. Trofatter J, MacCollin M, Rutter J, Murrell J, Duyao M, Parry D, et al. A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. Cell. 1993;72:791-800 pubmed
    Neurofibromatosis 2 (NF2) is a dominantly inherited disorder characterized by the occurrence of bilateral vestibular schwannomas and other central nervous system tumors including multiple meningiomas...
  6. Yogesha S, Sharff A, Giovannini M, Bricogne G, Izard T. Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor. Protein Sci. 2011;20:2113-20 pubmed publisher
    The merlin-1 tumor suppressor is encoded by the Neurofibromatosis-2 (Nf2) gene and loss-of-function Nf2 mutations lead to nervous system tumors in man and to several tumor types in mice...
  7. Yang C, Asthagiri A, Iyer R, Lu J, Xu D, Ksendzovsky A, et al. Missense mutations in the NF2 gene result in the quantitative loss of merlin protein and minimally affect protein intrinsic function. Proc Natl Acad Sci U S A. 2011;108:4980-5 pubmed publisher
    ..and is caused by a mutation of the NF2 tumor suppressor gene that encodes for the tumor suppressor protein merlin. Biallelic NF2 gene inactivation results in the development of central nervous system tumors, including ..
  8. Lee H, Kim D, Dan H, Wu E, Gritsko T, Cao C, et al. Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein. Mol Cell Biol. 2007;27:2103-19 pubmed
    ..However, the mechanisms by which the NF2 product, merlin or schwannomin, is regulated and controls cell proliferation remain elusive...
  9. Morrow K, Das S, Metge B, Ye K, Mulekar M, Tucker J, et al. Loss of tumor suppressor Merlin in advanced breast cancer is due to post-translational regulation. J Biol Chem. 2011;286:40376-85 pubmed publisher
    Unlike malignancies of the nervous system, there have been no mutations identified in Merlin in breast cancer. As such, the role of the tumor suppressor, Merlin, has not been investigated in breast cancer...
  10. Xiao G, Gallagher R, Shetler J, Skele K, Altomare D, Pestell R, et al. The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression. Mol Cell Biol. 2005;25:2384-94 pubmed
    ..Recent studies have demonstrated that merlin, the product of the NF2 gene, is regulated by Rac/PAK signaling...
  11. den Bakker M, Tascilar M, Riegman P, Hekman A, Boersma W, Janssen P, et al. Neurofibromatosis type 2 protein co-localizes with elements of the cytoskeleton. Am J Pathol. 1995;147:1339-49 pubmed
    The product of the neurofibromatosis type 2 (NF2) tumor suppressor gene is a 595-amino-acid protein bearing resemblance to a family of band-4.1-related proteins...
  12. Yin F, Yu J, Zheng Y, Chen Q, Zhang N, Pan D. Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2. Cell. 2013;154:1342-55 pubmed publisher
    Although Merlin/NF2 was discovered two decades ago as a tumor suppressor underlying Neurofibromatosis type II, its precise molecular mechanism remains poorly understood...
  13. Sun C, Robb V, Gutmann D. Protein 4.1 tumor suppressors: getting a FERM grip on growth regulation. J Cell Sci. 2002;115:3991-4000 pubmed
    ..1 molecules, include proteins that function as tumor suppressors. The ERM subgroup member merlin/schwannomin is inactivated in the tumor-predisposition syndrome neurofibromatosis 2 (NF2), and the prototypic 4...
  14. Huang L, Ichimaru E, Pestonjamasp K, Cui X, Nakamura H, Lo G, et al. Merlin differs from moesin in binding to F-actin and in its intra- and intermolecular interactions. Biochem Biophys Res Commun. 1998;248:548-53 pubmed
    The neurofibromatosis type 2 (NF2) tumor suppressor gene encodes merlin, a protein with homology to the cell membrane/F-actin linking proteins, moesin, ezrin and radixin...
  15. Bianchi A, Hara T, Ramesh V, Gao J, Klein Szanto A, Morin F, et al. Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types. Nat Genet. 1994;6:185-92 pubmed
    The neurofibromatosis 2 gene (NF2) has recently been isolated and predicted to encode a novel protein related to the moesin-ezrin-radixin family of cytoskeleton-associated proteins...
  16. Jannatipour M, Dion P, Khan S, Jindal H, Fan X, Laganiere J, et al. Schwannomin isoform-1 interacts with syntenin via PDZ domains. J Biol Chem. 2001;276:33093-100 pubmed
    ..The NF2 protein, called schwannomin or merlin, is inactivated in virtually all schwannomas and meningiomas...
  17. Scoles D, Huynh D, Morcos P, Coulsell E, Robinson N, Tamanoi F, et al. Neurofibromatosis 2 tumour suppressor schwannomin interacts with betaII-spectrin. Nat Genet. 1998;18:354-9 pubmed
    NF2 is the most commonly mutated gene in benign tumours of the human nervous system. The NF2 protein, called schwannomin or merlin, is absent in virtually all schwannomas, and many meningiomas and ependymomas...
  18. Muranen T, Grönholm M, Renkema G, Carpen O. Cell cycle-dependent nucleocytoplasmic shuttling of the neurofibromatosis 2 tumour suppressor merlin. Oncogene. 2005;24:1150-8 pubmed
    The neurofibromatosis 2 tumour suppressor merlin/schwannomin is structurally related to the ezrin-radixin-moesin family of proteins, which anchor actin cytoskeleton to specific membrane proteins and participate in cell signalling...
  19. Hansson C, Buckley P, Grigelioniene G, Piotrowski A, Hellström A, Mantripragada K, et al. Comprehensive genetic and epigenetic analysis of sporadic meningioma for macro-mutations on 22q and micro-mutations within the NF2 locus. BMC Genomics. 2007;8:16 pubmed
    ..The neurofibromatosis type 2 (NF2) tumor suppressor is the only gene known to be frequently involved in early development of meningiomas...
  20. Muranen T, Grönholm M, Lampin A, Lallemand D, Zhao F, Giovannini M, et al. The tumor suppressor merlin interacts with microtubules and modulates Schwann cell microtubule cytoskeleton. Hum Mol Genet. 2007;16:1742-51 pubmed
    The lack of neurofibromatosis 2 tumor suppressor protein merlin leads to the formation of nervous system tumors, specifically schwannomas and meningiomas...
  21. Horiguchi A, Zheng R, Shen R, Nanus D. Inactivation of the NF2 tumor suppressor protein merlin in DU145 prostate cancer cells. Prostate. 2008;68:975-84 pubmed publisher
    The neurofibromatosis 2 (NF2) tumor suppressor gene product merlin is an important regulator of contact-dependent cell proliferation...
  22. Poulikakos P, Xiao G, Gallagher R, Jablonski S, Jhanwar S, Testa J. Re-expression of the tumor suppressor NF2/merlin inhibits invasiveness in mesothelioma cells and negatively regulates FAK. Oncogene. 2006;25:5960-8 pubmed
    The neurofibromatosis type 2 NF2 gene product, merlin, is a tumor suppressor frequently inactivated in malignant mesothelioma (MM)...
  23. Lallemand D, Manent J, Couvelard A, Watilliaux A, Siena M, Chareyre F, et al. Merlin regulates transmembrane receptor accumulation and signaling at the plasma membrane in primary mouse Schwann cells and in human schwannomas. Oncogene. 2009;28:854-65 pubmed publisher
    The NF2 gene product, merlin/schwannomin, is a cytoskeleton organizer with unique growth-inhibiting activity in specific cell types...
  24. Scoles D, Yong W, Qin Y, Wawrowsky K, Pulst S. Schwannomin inhibits tumorigenesis through direct interaction with the eukaryotic initiation factor subunit c (eIF3c). Hum Mol Genet. 2006;15:1059-70 pubmed
    The neurofibromatosis 2 (NF2) tumor suppressor protein, schwannomin or merlin, is commonly lost upon NF2 gene mutation in benign human brain tumors...
  25. Gutmann D, Haipek C, Burke S, Sun C, Scoles D, Pulst S. The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility. Hum Mol Genet. 2001;10:825-34 pubmed
    The neurofibromatosis 2 tumor suppressor protein, merlin or schwannomin, functions as a negative growth regulator; however, its mechanism of action is not known...
  26. Li W, You L, Cooper J, Schiavon G, Pepe Caprio A, Zhou L, et al. Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus. Cell. 2010;140:477-90 pubmed publisher
    Current models imply that the FERM domain protein Merlin, encoded by the tumor suppressor NF2, inhibits mitogenic signaling at or near the plasma membrane...
  27. Stamenkovic I, Yu Q. Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival. Curr Protein Pept Sci. 2010;11:471-84 pubmed
    ..The product of NF2 gene is merlin (moesin-ezrin-radixin-like protein), a member of the Band 4.1 superfamily proteins...
  28. Kullar P, Pearson D, Malley D, Collins V, Ichimura K. CpG island hypermethylation of the neurofibromatosis type 2 (NF2) gene is rare in sporadic vestibular schwannomas. Neuropathol Appl Neurobiol. 2010;36:505-14 pubmed publisher
    Loss of both wild-type copies of the neurofibromatosis type 2 (NF2) gene is found in both sporadic and neurofibromatosis type 2-associated vestibular schwannomas (VS)...
  29. De Vitis L, Tedde A, Vitelli F, Ammannati F, Mennonna P, Bigozzi U, et al. Screening for mutations in the neurofibromatosis type 2 (NF2) gene in sporadic meningiomas. Hum Genet. 1996;97:632-7 pubmed
    ..They are usually sporadic but can also occur associated with the neurofibromatosis type 2 (NF2) syndrome...
  30. Lallemand D, Curto M, Saotome I, Giovannini M, McClatchey A. NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Genes Dev. 2003;17:1090-100 pubmed
    ..Recent studies suggest that Nf2 loss also contributes to tumor metastasis. The Nf2-encoded protein, merlin, is related to the ERM (ezrin, radixin, and moesin) family of membrane:cytoskeleton-associated proteins...
  31. Xiao G, Beeser A, Chernoff J, Testa J. p21-activated kinase links Rac/Cdc42 signaling to merlin. J Biol Chem. 2002;277:883-6 pubmed
    ..NF2 encodes a 595-amino acid protein, merlin, which exhibits significant homology to the ezrin-radixin-moesin family of proteins...
  32. Kressel M, Schmucker B. Nucleocytoplasmic transfer of the NF2 tumor suppressor protein merlin is regulated by exon 2 and a CRM1-dependent nuclear export signal in exon 15. Hum Mol Genet. 2002;11:2269-78 pubmed
    The neurofibromatosis 2 protein merlin is a classical tumor suppressor protein. Germline mutations predispose to the development of schwannomas, meningiomas and ependymomas. Merlin has been implicated in cellular migration and adhesion...
  33. Scoles D, Huynh D, Chen M, Burke S, Gutmann D, Pulst S. The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate. Hum Mol Genet. 2000;9:1567-74 pubmed
    The neurofibromatosis 2 tumor suppressor protein schwannomin/merlin is commonly mutated in schwannomas and meningiomas. Schwannomin, a member of the 4...
  34. Goutagny S, Yang H, Zucman Rossi J, Chan J, Dreyfuss J, Park P, et al. Genomic profiling reveals alternative genetic pathways of meningioma malignant progression dependent on the underlying NF2 status. Clin Cancer Res. 2010;16:4155-64 pubmed publisher
    ..WHO defines three grades predictive of the risk of recurrence. Clinical data supporting histologic malignant progression of meningiomas are sparse and underlying molecular mechanisms are not clearly depicted...
  35. López Lago M, Okada T, Murillo M, Socci N, Giancotti F. Loss of the tumor suppressor gene NF2, encoding merlin, constitutively activates integrin-dependent mTORC1 signaling. Mol Cell Biol. 2009;29:4235-49 pubmed publisher
    Integrin signaling promotes, through p21-activated kinase, phosphorylation and inactivation of the tumor suppressor merlin, thus removing a block to mitogenesis in normal cells...
  36. MacCollin M, Mohney T, Trofatter J, Wertelecki W, Ramesh V, Gusella J. DNA diagnosis of neurofibromatosis 2. Altered coding sequence of the merlin tumor suppressor in an extended pedigree. JAMA. 1993;270:2316-20 pubmed
    ..at-risk members of a large pedigree segregating NF2, an autosomal dominant disorder caused by inactivation of the merlin tumor suppressor encoded in chromosome band 22q12...
  37. Ruttledge M, Sarrazin J, Rangaratnam S, Phelan C, Twist E, Merel P, et al. Evidence for the complete inactivation of the NF2 gene in the majority of sporadic meningiomas. Nat Genet. 1994;6:180-4 pubmed
    ..The neurofibromatosis type 2 gene (NF2), a prime candidate for involvement in meningioma, was screened for point mutations...
  38. Fernandez Valle C, Tang Y, Ricard J, Rodenas Ruano A, Taylor A, Hackler E, et al. Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology. Nat Genet. 2002;31:354-62 pubmed
    ..It is caused by mutations in the gene NF2, encoding the growth regulator schwannomin (also known as merlin)...
  39. Chang L, Akhmametyeva E, Wu Y, Zhu L, Welling D. Multiple transcription initiation sites, alternative splicing, and differential polyadenylation contribute to the complexity of human neurofibromatosis 2 transcripts. Genomics. 2002;79:63-76 pubmed
    Northern blot analysis has shown that the human neurofibromatosis type 2 (NF2) cDNA hybridizes to multiple RNA species...
  40. Kim J, Kim I, Kwon S, Jang B, Suh S, Shin D, et al. Mutational analysis of the NF2 gene in sporadic meningiomas by denaturing high-performance liquid chromatography. Int J Mol Med. 2006;18:27-32 pubmed
    The NF2 tumor suppressor gene, located in chromosome 22q12, is involved in the development of sporadic meningiomas of the nervous system...
  41. Hartmann C, Sieberns J, Gehlhaar C, Simon M, Paulus W, von Deimling A. NF2 mutations in secretory and other rare variants of meningiomas. Brain Pathol. 2006;16:15-9 pubmed
    ..The WHO classification defines different histological variants of meningiomas. Mutations of the tumor suppressor gene NF2 on 22q have been described in 30% to 60 % of sporadic meningiomas...
  42. Gautreau A, Fievet B, Brault E, Antony C, Houdusse A, Louvard D, et al. Isolation and characterization of an aggresome determinant in the NF2 tumor suppressor. J Biol Chem. 2003;278:6235-42 pubmed
    b>Schwannomin (Sch) is the product of the NF2 tumor suppressor gene. The NF2 gene is mutated in patients affected by neurofibromatosis type 2, a syndrome associated with multiple tumors of the nervous system...
  43. Kino T, Takeshima H, Nakao M, Nishi T, Yamamoto K, Kimura T, et al. Identification of the cis-acting region in the NF2 gene promoter as a potential target for mutation and methylation-dependent silencing in schwannoma. Genes Cells. 2001;6:441-54 pubmed
    Although mutational inactivation and allelic loss in the NF2 gene appear to be causal events in the majority of vestibular schwannomas, involvement of another potentially important mechanism, transcriptional inactivation, has not been ..
  44. Grönholm M, Teesalu T, Tyynelä J, Piltti K, Bohling T, Wartiovaara K, et al. Characterization of the NF2 protein merlin and the ERM protein ezrin in human, rat, and mouse central nervous system. Mol Cell Neurosci. 2005;28:683-93 pubmed
    The neurofibromatosis 2 (NF2) protein, merlin, is structurally related to the ERM (ezrin-radixin-moesin) protein family of membrane-cytoskeleton linkers and is mutated in nervous system tumors...
  45. Fraenzer J, Pan H, Minimo L, Smith G, Knauer D, Hung G. Overexpression of the NF2 gene inhibits schwannoma cell proliferation through promoting PDGFR degradation. Int J Oncol. 2003;23:1493-500 pubmed
    ..The NF2 gene product, Merlin/Schwannomin, has recently been found to interact with the two PDZ domains containing protein EBP50/NHE-RF, which is itself ..
  46. Evans D, Watson C, King A, Wallace A, Baser M. Multiple meningiomas: differential involvement of the NF2 gene in children and adults. J Med Genet. 2005;42:45-8 pubmed
    To screen for NF2 mutations in people with meningiomas...
  47. Kissil J, Wilker E, Johnson K, Eckman M, Yaffe M, Jacks T. Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1. Mol Cell. 2003;12:841-9 pubmed
    The Nf2 tumor suppressor gene codes for merlin, a protein whose function has been elusive...
  48. Laulajainen M, Muranen T, Nyman T, Carpen O, Grönholm M. Multistep phosphorylation by oncogenic kinases enhances the degradation of the NF2 tumor suppressor merlin. Neoplasia. 2011;13:643-52 pubmed
    ..The NF2 gene encodes for the tumor suppressor protein merlin (moesin-ezrin-radixin-like protein), which functions as a linker between the plasma membrane and the cytoskeleton...
  49. Alfthan K, Heiska L, Grönholm M, Renkema G, Carpen O. Cyclic AMP-dependent protein kinase phosphorylates merlin at serine 518 independently of p21-activated kinase and promotes merlin-ezrin heterodimerization. J Biol Chem. 2004;279:18559-66 pubmed
    Mutations in the NF2 tumor suppressor gene encoding merlin induce the development of tumors of the nervous system. Merlin is highly homologous to the ERM (ezrin-radixin-moesin) family of membrane/cytoskeleton linker proteins...
  50. Rong R, Surace E, Haipek C, Gutmann D, Ye K. Serine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppression. Oncogene. 2004;23:8447-54 pubmed
    The neurofibromatosis 2 (NF2) tumor suppressor protein, merlin, functions as a negative growth regulator; however, the molecular mechanisms that underlie merlin regulation remain elusive...
  51. Lomas J, Bello M, Arjona D, Alonso M, Martinez Glez V, Lopez Marin I, et al. Genetic and epigenetic alteration of the NF2 gene in sporadic meningiomas. Genes Chromosomes Cancer. 2005;42:314-9 pubmed
    The role of the NF2 gene in the development of meningiomas has recently been documented; inactivating mutations plus allelic loss at 22q, the site of this gene (at 22q12), have been identified in both sporadic and neurofibromatosis type ..
  52. Grönholm M, Sainio M, Zhao F, Heiska L, Vaheri A, Carpen O. Homotypic and heterotypic interaction of the neurofibromatosis 2 tumor suppressor protein merlin and the ERM protein ezrin. J Cell Sci. 1999;112 ( Pt 6):895-904 pubmed
    ..The neurofibromatosis 2 (NF2) tumor suppressor protein merlin (schwannomin) is structurally related to ERM members...
  53. Chadee D, Xu D, Hung G, Andalibi A, Lim D, Luo Z, et al. Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein. Proc Natl Acad Sci U S A. 2006;103:4463-8 pubmed
    ..We find that merlin, the product of NF2, blunts the activation of both ERK and c-Jun N-terminal kinase (JNK)...
  54. Xu H, Gutmann D. Merlin differentially associates with the microtubule and actin cytoskeleton. J Neurosci Res. 1998;51:403-15 pubmed
    The neurofibromatosis 2 (NF2) suppressor gene encodes a protein termed merlin (or schwannomin) with sequence similarity to a family of proteins that link the actin cytoskeleton to cell surface glycoproteins...
  55. Yokoyama T, Osada H, Murakami H, Tatematsu Y, Taniguchi T, Kondo Y, et al. YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation. Carcinogenesis. 2008;29:2139-46 pubmed publisher
    ..We analyzed the involvement of YAP1 in MPM proliferation, as well as its functional and physical interaction with Merlin encoded by the neurofibromatosis type 2 (NF2) tumor suppressor gene, which is frequently mutated in MPMs...
  56. Lau Y, Murray L, Houshmandi S, Xu Y, Gutmann D, Yu Q. Merlin is a potent inhibitor of glioma growth. Cancer Res. 2008;68:5733-42 pubmed publisher
    ..The NF2 protein merlin (or schwannomin) is a member of the Band 4...
  57. Turunen O, Sainio M, Jaaskelainen J, Carpen O, Vaheri A. Structure-function relationships in the ezrin family and the effect of tumor-associated point mutations in neurofibromatosis 2 protein. Biochim Biophys Acta. 1998;1387:1-16 pubmed
    ..b>Merlin, the tumor suppressor in neurofibromatosis 2, is a diverged member of the ezrin family, but its function is at ..