Gene Symbol: NF E2
Description: nuclear factor, erythroid 2
Alias: NF-E2, p45, transcription factor NF-E2 45 kDa subunit, leucine zipper protein NF-E2, nuclear factor (erythroid-derived 2), 45kD, nuclear factor (erythroid-derived 2), 45kDa, nuclear factor, erythroid-derived 2 45 kDa subunit, p45 NF-E2
Species: human
Products:     NF E2

Top Publications

  1. Igarashi K, Kataoka K, Itoh K, Hayashi N, Nishizawa M, Yamamoto M. Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins. Nature. 1994;367:568-72 pubmed
    Transcription factor NF-E2 is crucial for regulating erythroid-specific gene expression. Cloning of the NF-E2 p45 protein has revealed that it contains a basic region-leucine zipper (b-zip) domain which associates with another ..
  2. Blank V, Kim M, Andrews N. Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression. Blood. 1997;89:3925-35 pubmed
    ..Earlier work proposed that p18(MafK) forms a heterodimer with hematopoietic-specific protein p45 NF-E2 to activate transcription through NF-E2 sites...
  3. Gavva N, Wen S, Daftari P, Moniwa M, Yang W, Yang Feng L, et al. NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressor. Genomics. 2002;79:423-31 pubmed
    ..we used expression cloning to identify coregulators interacting with the erythroid-specific subunit of NF-E2, p45. We have isolated a protein, NAPP2, which contains an aspartic-acid- and glutamic-acid-rich region and a nuclear ..
  4. Onishi Y, Kiyama R. Interaction of NF-E2 in the human beta-globin locus control region before chromatin remodeling. J Biol Chem. 2003;278:8163-71 pubmed
    ..These lines of evidence indicate that NF-E2 interacts with the cognate motif on the nucleosome before chromatin is remodeled. ..
  5. Lee T, Shyu Y, Hsu T, Shen C. Itch regulates p45/NF-E2 in vivo by Lys63-linked ubiquitination. Biochem Biophys Res Commun. 2008;375:326-30 pubmed publisher
    The hematopoietic-specific transcription factor p45/NF-E2 is an important transcriptional activator in the erythroid and megakaryocytic lineages...
  6. Zhou Z, Li X, Deng C, Ney P, Huang S, BUNGERT J. USF and NF-E2 cooperate to regulate the recruitment and activity of RNA polymerase II in the beta-globin gene locus. J Biol Chem. 2010;285:15894-905 pubmed publisher
    ..The data provide mechanistic insight into how ubiquitous and tissue-restricted transcription factors cooperate to regulate the recruitment and activity of transcription complexes in a tissue-specific chromatin domain. ..
  7. Kaufmann K, Gründer A, Hadlich T, Wehrle J, Gothwal M, Bogeska R, et al. A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2. J Exp Med. 2012;209:35-50 pubmed publisher
    ..These data establish a role for NF-E2 in the pathophysiology of MPNs and provide a molecular rationale for investigating epigenetic alterations as novel targets for rationally designed MPN therapies...
  8. Gavva N, Gavva R, Ermekova K, Sudol M, Shen C. Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II. J Biol Chem. 1997;272:24105-8 pubmed
    ..By Far-Western blotting and yeast two-hybrid assay, we demonstrate that p45, the large subunit of NF-E2, is capable of binding to a specific set of WW domain-containing proteins, including ..
  9. Hung H, Kim A, Hong W, Rakowski C, Blobel G. Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation. J Biol Chem. 2001;276:10715-21 pubmed
    ..We found that both the hematopoietic-specific subunit of NF-E2, p45, and the widely expressed small subunit, MafG, interact with CBP in vitro and in vivo...

More Information

Publications115 found, 100 shown here

  1. Chen X, Wen S, Fukuda M, Gavva N, Hsu D, Akama T, et al. Human ITCH is a coregulator of the hematopoietic transcription factor NF-E2. Genomics. 2001;73:238-41 pubmed
    We have cloned a new protein that interacts with the hematopoietic DNA-binding transcription factor, p45/NF-E2, by screening a human erythroleukemia cell cDNA library with the yeast two-hybrid approach...
  2. Boulanger L, Sabatino D, Wong E, Cline A, Garrett L, Garbarz M, et al. Erythroid expression of the human alpha-spectrin gene promoter is mediated by GATA-1- and NF-E2-binding proteins. J Biol Chem. 2002;277:41563-70 pubmed
    ..No expression of the reporter gene was detected in nonerythroid tissues. We conclude that this alpha-spectrin gene promoter contains the sequences necessary for low level expression in erythroid progenitor cells. ..
  3. Wang W, Schwemmers S, Hexner E, Pahl H. AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2. Blood. 2010;116:254-66 pubmed publisher
    ..Our data identify NF-E2 as a novel AML1 target gene and delineate a role for aberrant AML1 expression in mediating elevated NF-E2 expression in MPN patients...
  4. Bisig C, Roth M, Müller L, Comte P, Heeb N, Mayer A, et al. Hazard identification of exhausts from gasoline-ethanol fuel blends using a multi-cellular human lung model. Environ Res. 2016;151:789-796 pubmed publisher
    ..So far ethanol-gasoline blends can promptly be used, though further studies, e.g. chronic and in vivo studies, are needed. ..
  5. Degroote S, Hunting D, Takser L. Periconceptional folate deficiency leads to autism-like traits in Wistar rat offspring. Neurotoxicol Teratol. 2018;66:132-138 pubmed publisher
    ..P30), elevated plus maze (P35), and prepulse inhibition of the acoustic startle reflex (sensorimotor gating) (P45). Blood homocysteine levels were used to confirm the deficit in one‑carbon donors...
  6. Markovic J, Stosic M, Kojić D, Matavulj M. Effects of acrylamide on oxidant/antioxidant parameters and CYP2E1 expression in rat pancreatic endocrine cells. Acta Histochem. 2018;120:73-83 pubmed publisher
    ..status and the activity of CAT, SOD and glutathione-S-transferase (GST), their gene expression, and CYP2E1, NF-E2 p45-related factor 2 (Nrf2) and iNOS expression...
  7. Narasimhan M, Rajasekaran N. Cardiac Aging - Benefits of Exercise, Nrf2 Activation and Antioxidant Signaling. Adv Exp Med Biol. 2017;999:231-255 pubmed publisher
    ..Natural defense system to fight against OS involves a master transcription factor named nuclear erythroid-2-p45-related factor-2 (Nrf2) that regulates several antioxidant genes...
  8. Mai Y, Li Y, Li R, Li W, Huang X, Mo Z, et al. Proteomic analysis of differentially expressed proteins in the marine fish parasitic ciliate Cryptocaryon irritans. Vet Parasitol. 2015;211:1-11 pubmed publisher
    ..points; 4 proteins (vacuolar ATP synthase catalytic subunit α, mcm2-3-5 family protein, 26S proteasome subunit P45 family protein and dnaK protein) were highly expressed only in theronts; while protein kinase domain containing ..
  9. Liu H, Wu H, Wang W, Zhao Z, Liu X, Wang L. Regulation of miR-92a on vascular endothelial aging via mediating Nrf2-KEAP1-ARE signal pathway. Eur Rev Med Pharmacol Sci. 2017;21:2734-2742 pubmed
    ..Nrf2, KEAP1 and ARE mRNA expressions were measured by real-time PCR. Nuclear factor erythroid 2 p45 related factor 2 (Nrf2) protein level, inflammatory factors tumor necrosis factor ? (TNF-?) and interleukin-2 (IL-2)..
  10. Agathanggelou A, Weston V, Perry T, Davies N, Skowronska A, Payne D, et al. Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants. Haematologica. 2015;100:1076-85 pubmed publisher
    ..leukemia, pro-oxidant treatment of Ataxia Telangiectasia Mutated-null cells led to reduced binding of NF-E2 p45-related factor-2 to antioxidant response elements and thus decreased expression of target genes...
  11. Yang Y, Luo L, Cai X, Fang Y, Wang J, Chen G, et al. Nrf2 inhibits oxaliplatin-induced peripheral neuropathy via protection of mitochondrial function. Free Radic Biol Med. 2018;120:13-24 pubmed publisher
    ..Besides its antioxidant activity, the transcription factor, nuclear factor-erythroid 2 (NF-E2) p45-related factor 2 (Nrf2) plays a crucial role in the maintenance of mitochondrial homeostasis, and mitochondrial ..
  12. Xu X, Wang S, Jin Y, Hu Y, Feng K, Ma Z. Melatonin delays photoreceptor degeneration in a mouse model of autosomal recessive retinitis pigmentosa. J Pineal Res. 2017;63: pubmed publisher
    ..Retinas treated with melatonin or vehicle were harvested for analysis at P30 and P45, respectively...
  13. Tang J, Liu C, Min J, Hu M, Li Y, Hong L. Potential therapeutic role of punicalagin against mechanical-trauma-induced stress urinary incontinence via upregulation of Nrf2 and TGF-β1 signaling : Effect of punicalagin on mechanical trauma induced SUI. Int Urogynecol J. 2017;28:947-955 pubmed publisher
    ..smooth muscle actin (SMA), transforming growth factor (TGF)-β1, and p-Smad3, nuclear factor-erythroid 2 p45-related factor 2 (Nrf2), and glutathione peroxidase (GPx1) protein levels, and increase of 8-hydroxydeoxyguanosine (..
  14. Alteba S, Korem N, Akirav I. Cannabinoids reverse the effects of early stress on neurocognitive performance in adulthood. Learn Mem. 2016;23:349-58 pubmed publisher
    ..2 mg/kg, i.p.) for 2 wk during late adolescence (P45-60) and tested in adulthood (P90) for working memory, anxiety, and alterations in CB1 receptors (CB1r), and ..
  15. Panisello Roselló A, Alva N, Flores M, Lopez A, Castro Benitez C, Folch Puy E, et al. Aldehyde Dehydrogenase 2 (ALDH2) in Rat Fatty Liver Cold Ischemia Injury. Int J Mol Sci. 2018;19: pubmed publisher
    ..Variations in ATP levels were also determined. The results were consistent with levels of NF-E2 p45-related factor 2 (Nrf2), an antioxidant factor...
  16. Bayele H, Balesaria S, Srai S. Phytoestrogens modulate hepcidin expression by Nrf2: Implications for dietary control of iron absorption. Free Radic Biol Med. 2015;89:1192-202 pubmed publisher
    ..The ability of phytoestrogens to modulate hepcidin expression in vivo suggests a novel mechanism by which diet may impact iron homeostasis. ..
  17. Silva Palacios A, Ostolga Chavarría M, Zazueta C, Konigsberg M. Nrf2: Molecular and epigenetic regulation during aging. Ageing Res Rev. 2018;47:31-40 pubmed publisher
    ..Nrf2 (Nuclear factor-erythroid 2-p45 derived factor 2) controls the expression of genes whose products include antioxidant proteins, detoxifying enzymes,..
  18. Khalifeh S, Fakhfouri G, Mehr S, Mousavizadeh K, Dehpour A, Khodagholi F, et al. Beyond the 5-HT3 receptors: A role for α7nACh receptors in neuroprotective aspects of tropisetron. Hum Exp Toxicol. 2015;34:922-31 pubmed publisher
    ..effects by upregulation of heme oxygenase-1, glutathione, catalase activity, and nuclear factor-erythroid 2 p45-related factor 2 level...
  19. Hecker L, Logsdon N, Kurundkar D, Kurundkar A, Bernard K, Hock T, et al. Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance. Sci Transl Med. 2014;6:231ra47 pubmed publisher
    ..Our studies suggest that restoration of Nox4-Nrf2 redox balance in myofibroblasts may be a therapeutic strategy in age-associated fibrotic disorders, potentially able to resolve persistent fibrosis or even reverse its progression. ..
  20. Randhawa R, Sehgal M, Singh T, Duseja A, Changotra H. Unc-51 like kinase 1 (ULK1) in silico analysis for biomarker identification: a vital component of autophagy. Gene. 2015;562:40-9 pubmed publisher
    ..Furthermore, 4 palmitoylation sites at positions 426, 927, 1003 and 1049 were also found which could further be studied for protein-protein interactions as well as in trafficking. ..
  21. Wu J, Cheng C, Shen L, Wang Z, Wu S, Li W, et al. Synthetic chalcones with potent antioxidant ability on Hâ‚‚Oâ‚‚-induced apoptosis in PC12 cells. Int J Mol Sci. 2014;15:18525-39 pubmed publisher
    ..and western blot analysis showed that 1 and 1d significantly improve the expression of nuclear factor erythroid 2 p45-related factor 2 (Nrf2)-dependent antioxidant genes g-Glutamylcysteine Ligase Catalytic Subunit (GCLC) and heme ..
  22. Li D, Gu Z, Zhang J, Ma S. Protective effect of inducible aldo-keto reductases on 4-hydroxynonenal- induced hepatotoxicity. Chem Biol Interact. 2019;304:124-130 pubmed publisher
    ..Moreover, transcriptional factor nuclear factor erythroid 2 p45-related factor 2 (Nrf2) is activated by HNE through translocation to the nucleus...
  23. Potts K, Sargeant T, Dawson C, Josefsson E, Hilton D, Alexander W, et al. Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL. Blood. 2015;126:807-16 pubmed publisher
  24. Chen Q, Peng H, Dong L, Chen L, Ma X, Peng Y, et al. Activation of the NRF2-ARE signalling pathway by the Lentinula edodes polysaccharose LNT alleviates ROS-mediated cisplatin nephrotoxicity. Int Immunopharmacol. 2016;36:1-8 pubmed publisher
    ..LNT itself could not eliminate ROS levels in vitro. Further studies demonstrated that LNT induced NF-E2 p45-related factor 2 (Nrf2) protein and mRNA expression in a time- and dose-dependent manner...
  25. Xie G, Meng X, Wang F, Bao Y, Huo J. Eriodictyol attenuates arsenic trioxide-induced liver injury by activation of Nrf2. Oncotarget. 2017;8:68668-68674 pubmed publisher
    ..In addition, eriodictyol promoted the expression of nuclear factor erythroid 2 p45 related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) up-regulated by As2O3...
  26. Yu Y, Wang C, Wang A, Yang W, Lv F, Liu F, et al. Effects of various feeding patterns of Bacillus coagulans on growth performance, antioxidant response and Nrf2-Keap1 signaling pathway in juvenile gibel carp (Carassius auratus gibelio). Fish Shellfish Immunol. 2018;73:75-83 pubmed publisher
    ..coagulans could improve the growth, immune response, and antioxidant capability of gibel carp. We concluded that the pattern of two days of 500 or 1000 mg/kg B. coagulans after 5 days of a basal diet was recommended for gibel carp. ..
  27. Kowluru R, Mishra M. Epigenetic regulation of redox signaling in diabetic retinopathy: Role of Nrf2. Free Radic Biol Med. 2017;103:155-164 pubmed publisher
    ..addition to other cellular and enzymatic defense systems, the retina is also equipped with the nuclear erythroid-2-p45-related factor-2 (Nrf2) antioxidant response element signaling pathway, which controls the expression of genes ..
  28. Bogeska R, Pahl H. Elevated nuclear factor erythroid-2 levels promote epo-independent erythroid maturation and recapitulate the hematopoietic stem cell and common myeloid progenitor expansion observed in polycythemia vera patients. Stem Cells Transl Med. 2013;2:112-7 pubmed publisher
    ..Silencing NF-E2 in PV patients reverted both aberrancies, demonstrating for the first time that NF-E2 overexpression is both required and sufficient for Epo independence and HSC/CMP expansion in PV. ..
  29. Pan G, Yang J, Hu X, Li X. Postnatal development of the electrophysiological properties of somatostatin interneurons in the anterior cingulate cortex of mice. Sci Rep. 2016;6:28137 pubmed publisher
    ..However, their development in the ACC remains unclear. Using postnatal day 3 (P3) to P45 GIN mice, we found that most of the intrinsic membrane properties of SST interneurons in the ACC were ..
  30. Park S, Kim Y, Park G. Anti-neuro-inflammatory effects of Nardostachys chinensis in lipopolysaccharide-and lipoteichoic acid-stimulated microglial cells. Chin J Nat Med. 2016;14:343-53 pubmed publisher
    ..In conclusion, our findings indicate that EN could be used as a natural anti-neuro-inflammatory and neuroprotective agent. ..
  31. Nakata H, Namba M, Kakigi R, Shibasaki M. Effects of face/head and whole body cooling during passive heat stress on human somatosensory processing. Am J Physiol Regul Integr Comp Physiol. 2017;312:R996-R1003 pubmed publisher
    ..The latencies and amplitudes of P14, N20, P25, N35, P45, and N60 at C4' and P14, N18, P22, and N30 at Fz were evaluated...
  32. Hamey F, Nestorowa S, Kinston S, Kent D, Wilson N, Gottgens B. Reconstructing blood stem cell regulatory network models from single-cell molecular profiles. Proc Natl Acad Sci U S A. 2017;114:5822-5829 pubmed publisher
    ..Our approach confirms known aspects of hematopoiesis, provides hypotheses about regulation of HSC differentiation, and is widely applicable to other hierarchical biological systems to uncover regulatory relationships. ..
  33. Saalfield J, Spear L. Consequences of repeated ethanol exposure during early or late adolescence on conditioned taste aversions in rats. Dev Cogn Neurosci. 2015;16:174-182 pubmed publisher
    ..g. ethanol (25%) or water every 48 h from postnatal day (P) 25-45 (early AIE) or P45-65 (late AIE), or were left non-manipulated (NM)...
  34. Zhang Y, Xiang Y. Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity. Biochem J. 2016;473:961-1000 pubmed publisher
    ..g. sMaf, c-Jun, JunD or c-Fos), to regulate different sets of cognate genes. Among them, NF-E2 p45 and Nrf3 are subject to tissue-specific expression in haemopoietic and placental cell lineages respectively...
  35. Warfel N, Sainz A, Song J, Kraft A. PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species. Mol Cancer Ther. 2016;15:1637-47 pubmed publisher
    ..hypoxia-induced oxidative stress by increasing the nuclear localization and activity of nuclear factor-erythroid 2 p45-related factor 2 (Nrf2), which functions to increase the expression of antioxidant genes...
  36. Friedrich S, Engelmann S, Schmidt T, Szczepankiewicz G, Bergs S, Liebert U, et al. The Host Factor AUF1 p45 Supports Flavivirus Propagation by Triggering the RNA Switch Required for Viral Genome Cyclization. J Virol. 2018;92: pubmed publisher
    ..Further studies demonstrated that the AUF1 isoform p45 significantly stimulates the initiation of viral RNA replication and that the protein's RNA chaperone activity ..
  37. Dinkova Kostova A, Baird L, Holmström K, Meyer C, Abramov A. The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics. Biochem Soc Trans. 2015;43:602-10 pubmed publisher
    The Kelch-like ECH associated protein 1 (Keap1)-NF-E2 p45-related factor 2 (Nrf2) pathway regulates networks of proteins that protect against the cumulative damage of oxidants, electrophiles and misfolded proteins...
  38. Zhu Y, Wang P, Zhao Y, Yang C, Clark A, Leung T, et al. Synthesis, evaluation, and metabolism of novel [6]-shogaol derivatives as potent Nrf2 activators. Free Radic Biol Med. 2016;95:243-54 pubmed publisher
    ..The Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2 p45-related factor 2 (Nrf2) system is a major regulatory pathway of cytoprotective genes against oxidative and ..
  39. Zhang J, Tang W, Zhang Z, Luan B, Yu S, Sui H. Connection of the Posterior Occipital Muscle and Dura Mater of the Siamese Crocodile. Anat Rec (Hoboken). 2016;299:1402-8 pubmed publisher
    ..a myodural bridge exists in reptiles, six Siamese crocodiles were investigated using gross anatomy dissection and P45 sheet plastination technologies...
  40. di Tullio A, Passaro D, Rouault Pierre K, Purewal S, Bonnet D. Nuclear Factor Erythroid 2 Regulates Human HSC Self-Renewal and T Cell Differentiation by Preventing NOTCH1 Activation. Stem Cell Reports. 2017;9:5-11 pubmed publisher
    ..This effect is at least partly due to Notch1 downregulation in NF-E2-silenced HSPCs. Together these data reveal that NF-E2 is an important driver of human hematopoietic stem cell maintenance and T lineage differentiation. ..
  41. Mosser E, Kasanov J, Forsberg E, Kay B, Ney P, Bresnick E. Physical and functional interactions between the transactivation domain of the hematopoietic transcription factor NF-E2 and WW domains. Biochemistry. 1998;37:13686-95 pubmed
    ..NF-E2 is a heterodimer consisting of a hematopoietic subunit p45 and a ubiquitous subunit p18. Gavva et al. [Gavva, N. R., Gavva, R., Ermekova, K., Sudol, M., and Shen, J. C...
  42. Quinti L, Casale M, Moniot S, Pais T, Van Kanegan M, Kaltenbach L, et al. SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models. Cell Chem Biol. 2016;23:849-861 pubmed publisher of the lead-compound, MIND4, as an inducer of cytoprotective NRF2 (nuclear factor-erythroid 2 p45-derived factor 2) activity...
  43. Stagni F, Giacomini A, Emili M, Trazzi S, Guidi S, Sassi M, et al. Short- and long-term effects of neonatal pharmacotherapy with epigallocatechin-3-gallate on hippocampal development in the Ts65Dn mouse model of Down syndrome. Neuroscience. 2016;333:277-301 pubmed publisher
    ..The effects of treatment were examined at its cessation (at P15) or after one month (at P45)...
  44. Chen M, Bi A, Zhang Y, Yan Q, Sun Y, Zhang X, et al. Different patterns of changes between actin dynamics and synaptic density in the rat's primary visual cortex during a special period of visual development. Brain Res Bull. 2017;132:199-203 pubmed publisher
    ..synaptic density in the monocular area of primary visual cortex (V1M) maintained a stable high level from P30 to P45. The mechanisms underlying the different patterned of change in synaptic density and actin rearrangements from P30 ..
  45. Asciutto G, Wigren M, Fredrikson G, Mattisson I, Grönberg C, Alm R, et al. Apolipoprotein B-100 Antibody Interaction With Atherosclerotic Plaque Inflammation and Repair Processes. Stroke. 2016;47:1140-3 pubmed publisher
    Treatment with IgG against the malondialdehyde (MDA)-modified apolipoprotein B-100 epitope p45 reduces atherosclerosis in experimental models...
  46. Zhang B, Xu J, Li C, Shi S, Ji S, Xu W, et al. MBD1 is an Epigenetic Regulator of KEAP1 in Pancreatic Cancer. Curr Mol Med. 2016;16:404-11 pubmed
    MBD1 (Methyl-CpG Binding Domain Protein 1) is highly expressed in pancreatic cancer. Nrf2 (NF-E2 p45-related factor 2) and the 'antioxidant response element' (ARE)-driven genes that NRF2 controls are frequently upregulated in pancreatic ..
  47. Yum H, Na H, Surh Y. Anti-inflammatory effects of docosahexaenoic acid: Implications for its cancer chemopreventive potential. Semin Cancer Biol. 2016;40-41:141-159 pubmed publisher
    ..These include nuclear factor κB, peroxisome proliferator-activated receptor γ, nuclear factor erythroid 2 p45-related factor 2 and sterol regulatory element-binding protein 1...
  48. Bath K, Pimentel T. Effect of early postnatal exposure to valproate on neurobehavioral development and regional BDNF expression in two strains of mice. Epilepsy Behav. 2017;70:110-117 pubmed publisher
    ..well as impairments in the righting reflex (P7-8), wire hang (P17), open field (P12 and P21), and rotarod (P25 and P45) tasks. Interestingly, some of the early locomotor effects were strain- and dose-dependent...
  49. Sakai E, Morita M, Ohuchi M, Kido M, Fukuma Y, Nishishita K, et al. Effects of deficiency of Kelch-like ECH-associated protein 1 on skeletal organization: a mechanism for diminished nuclear factor of activated T cells cytoplasmic 1 during osteoclastogenesis. FASEB J. 2017;31:4011-4022 pubmed publisher
    Kelch-like ECH-associated protein 1 (Keap1) binds to nuclear factor E2 p45-related factor 2 (Nrf2), a transcription factor for antioxidant enzymes, to suppress Nrf2 activation...
  50. Pereira A, Fernandes R, Crisóstomo J, Seiça R, Sena C. The Sulforaphane and pyridoxamine supplementation normalize endothelial dysfunction associated with type 2 diabetes. Sci Rep. 2017;7:14357 pubmed publisher
    ..Activators of Nrf2 can be used therapeutically in association with inhibitors of AGE and cross-linking formation to normalize endothelial dysfunction in type 2 diabetes. ..
  51. Mathur A, Rizvi F, Kakkar P. PHLPP2 down regulation influences nuclear Nrf2 stability via Akt-1/Gsk3β/Fyn kinase axis in acetaminophen induced oxidative renal toxicity: Protection accorded by morin. Food Chem Toxicol. 2016;89:19-31 pubmed publisher
    NF-E2 p45-related factor 2 (Nrf2) is a cap 'n' collar (CNC) basic region-leucine zipper (bZIP) transcription factor that imparts cellular defence against xenobiotic and oxidative stress evoked responses by inducing an array of ..
  52. Degroote S, Hunting D, Baccarelli A, Takser L. Maternal gut and fetal brain connection: Increased anxiety and reduced social interactions in Wistar rat offspring following peri-conceptional antibiotic exposure. Prog Neuropsychopharmacol Biol Psychiatry. 2016;71:76-82 pubmed publisher
    ..burying (P30), elevated plus maze (P35), and prepulse inhibition of the acoustic startle reflex (sensory gating) (P45)...
  53. Friedrich S, Schmidt T, Schierhorn A, Lilie H, Szczepankiewicz G, Bergs S, et al. Arginine methylation enhances the RNA chaperone activity of the West Nile virus host factor AUF1 p45. RNA. 2016;22:1574-91 pubmed publisher
    ..Our earlier studies indicated that the p45 isoform of the cellular AU-rich element binding protein 1 (AUF1) has an RNA chaperone activity, which supports RNA ..
  54. Sihvola V, Levonen A. Keap1 as the redox sensor of the antioxidant response. Arch Biochem Biophys. 2017;617:94-100 pubmed publisher
    ..ECH]-associated protein 1), which is a negative regulator of transcription factor Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and the central hub for sensing endogenous and environmental oxidative and electrophilic ..
  55. Aracri P, Meneghini S, Coatti A, Amadeo A, Becchetti A. ?4?2? nicotinic receptors stimulate GABA release onto fast-spiking cells in layer V of mouse prefrontal (Fr2) cortex. Neuroscience. 2017;340:48-61 pubmed publisher
    ..This percentage decreased to ?5% in mice older than P45. By confocal microscopy, the ?4 nAChR subunit was immunocytochemically identified on interneurons expressing either ..
  56. Nakata H, Aoki M, Sakamoto K. Effects of mastication on human somatosensory processing: A study using somatosensory-evoked potentials. Neurosci Res. 2017;117:28-34 pubmed publisher
    ..Control included the same five sessions. The amplitudes and latencies of P14, N20, P25, N35, P45, and N60 components at C3', frontal N30 component at Fz, and P100 and N140 components at Pz were analyzed...
  57. Kerry S. Australian Queer Science Fiction Fans. J Homosex. 2017;:1-17 pubmed publisher
    ..Furthermore, while enjoying the "sciency" (P10, bisexual woman) aspects of sf, Australian queers also like the "poignant metaphors for our own civilization" (P45, asexual man).
  58. Dinkova Kostova A, Kostov R, Canning P. Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants. Arch Biochem Biophys. 2017;617:84-93 pubmed publisher
    ..The best-characterized substrate of Keap1 is transcription factor NF-E2 p45-related factor 2 (Nrf2), which orchestrates an elaborate transcriptional program in response to environmental ..
  59. Fiorani M, Guidarelli A, Capellacci V, Cerioni L, Crinelli R, Cantoni O. The dual role of mitochondrial superoxide in arsenite toxicity: Signaling at the boundary between apoptotic commitment and cytoprotection. Toxicol Appl Pharmacol. 2018;345:26-35 pubmed publisher
    ..We found that a low concentration of the metalloid causes an early activation of nuclear factor erythroid 2 p45-related factor 2 (Nrf2), and a downstream signaling leading to enhanced GSH biosynthesis, via a mechanism sensitive ..
  60. Yocum A, Steiner L, Seidel N, Cline A, Rout E, Lin J, et al. A tissue-specific chromatin loop activates the erythroid ankyrin-1 promoter. Blood. 2012;120:3586-93 pubmed publisher
    ..These observations demonstrate a model for the tissue-specific activation of alternative promoters that may be applicable to the ? 30% of mammalian genes with alternative promoters that exhibit distinct expression patterns. ..
  61. Avanzi M, Goldberg F, Davila J, Langhi D, Chiattone C, Mitchell W. Rho kinase inhibition drives megakaryocyte polyploidization and proplatelet formation through MYC and NFE2 downregulation. Br J Haematol. 2014;164:867-76 pubmed publisher
    ..Our findings suggest a model whereby ROCK inhibition drives polyploidization, DMS growth and proplatelet formation late in megakaryocyte maturation through downregulation of MYC and NFE2 expression. ..
  62. Stagni F, Giacomini A, Guidi S, Emili M, Uguagliati B, Salvalai M, et al. A flavonoid agonist of the TrkB receptor for BDNF improves hippocampal neurogenesis and hippocampus-dependent memory in the Ts65Dn mouse model of DS. Exp Neurol. 2017;298:79-96 pubmed publisher
    ..In order to establish the functional outcome of treatment, mice were treated with 7,8-DHF from P3 to adolescence (P45-50) and were tested with the Morris Water Maze...
  63. Newman J, Keating A. Comprehensive identification of human bZIP interactions with coiled-coil arrays. Science. 2003;300:2097-101 pubmed
    ..Biophysical studies in solution support the relative binding strengths observed with the arrays. New associations provide insights into the circadian clock and the unfolded protein response. ..
  64. Chuen C, Li K, Yang M, Fok T, Li C, Chui C, et al. Interleukin-1beta up-regulates the expression of thrombopoietin and transcription factors c-Jun, c-Fos, GATA-1, and NF-E2 in megakaryocytic cells. J Lab Clin Med. 2004;143:75-88 pubmed
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