Gene Symbol: neurotrypsin
Description: serine protease 12
Alias: BSSP-3, BSSP3, MRT1, neurotrypsin, brain-specific serine protease 3, leydin, protease, serine 12, protease, serine, 12 (neurotrypsin, motopsin)
Species: human
Products:     neurotrypsin

Top Publications

  1. Dufreneix F, Faverdin P, Peyraud J. Influence of particle size and density on mean retention time in the rumen of dairy cows. J Dairy Sci. 2019;102:3010-3022 pubmed publisher
    ..fitted to a double exponential model to calculate total MRT in the digestive tract (TMRT), MRT in 2 compartments (MRT1 and MRT2), and retention time in the intestines' tubular section (TT)...
  2. Hidaka C, Kashio T, Uchigaki D, Mitsui S. Vulnerability or resilience of motopsin knockout mice to maternal separation stress depending on adulthood behaviors. Neuropsychiatr Dis Treat. 2018;14:2255-2268 pubmed publisher
    ..Defective neuronal circuits in the prefrontal cortex may add to this complexity. ..
  3. Tsilibary E, Tzinia A, Radenovic L, Stamenkovic V, Lebitko T, Mucha M, et al. Neural ECM proteases in learning and synaptic plasticity. Prog Brain Res. 2014;214:135-57 pubmed publisher
    ..The data are especially strong for such serine proteases as thrombin, tissue plasminogen activator, neurotrypsin, and neuropsin as well as matrix metalloproteinases, MMP-9 in particular...
  4. Gomez Iturriaga A, Casquero F, Pijoan J, Crook J, Urresola A, Ezquerro A, et al. Pretreatment Multiparametric Magnetic Resonance Imaging Findings Are More Accurate Independent Predictors of Outcome Than Clinical Variables in Localized Prostate Cancer. Int J Radiat Oncol Biol Phys. 2018;101:1172-1178 pubmed publisher
    ..The median age was 71 years (range 56-82). Of the patients, 20.5% had mpMRI-determined (mrT) stage mrT1-mrT2b, 37.3% had mrT2c, 31% had mrT3a, and 11.2% had mrT3b. The Gleason score was 6 in 22.2%, 7 in 49...
  5. Aare S, Spendiff S, Vuda M, Elkrief D, Pérez A, Wu Q, et al. Failed reinnervation in aging skeletal muscle. Skelet Muscle. 2016;6:29 pubmed publisher
    ..from young adult (YA) and very old (VO) rats and from a murine model of sporadic denervation secondary to neurotrypsin over-expression (Sarco mouse)...
  6. Daryadel A, Haubitz M, Figueiredo M, Steubl D, Roos M, Mäder A, et al. The C-Terminal Fragment of Agrin (CAF), a Novel Marker of Renal Function, Is Filtered by the Kidney and Reabsorbed by the Proximal Tubule. PLoS ONE. 2016;11:e0157905 pubmed publisher
    Agrin, a multidomain proteoglycan and neurotrypsin, a neuronal serine protease, are important for forming (neuromuscular) synapses...
  7. Li G, Liu Y, Liu C, Su Z, Ren S, Wang Y, et al. Genome-wide analyses of long noncoding RNA expression profiles correlated with radioresistance in nasopharyngeal carcinoma via next-generation deep sequencing. BMC Cancer. 2016;16:719 pubmed publisher
    ..595, p < 0.05). Our study provides an overview of the expression profiles of radioresistant lncRNAs and potentially related mRNAs, which will facilitate future investigations into the function of lncRNAs in NPC radioresistance. ..
  8. Schachtschneider K, Liu Y, Rund L, Madsen O, Johnson R, Groenen M, et al. Impact of neonatal iron deficiency on hippocampal DNA methylation and gene transcription in a porcine biomedical model of cognitive development. BMC Genomics. 2016;17:856 pubmed
    ..Together, these results provide new insights into the mechanisms through which neonatal iron deficiency results in long lasting reductions in cognitive development in humans. ..
  9. Peng S, Xu J, Pelkey K, Chandra G, Zhang Z, Bagh M, et al. Suppression of agrin-22 production and synaptic dysfunction in Cln1 (-/-) mice. Ann Clin Transl Neurol. 2015;2:1085-104 pubmed publisher
    ..protein-δ, stimulated expression of serpina1, which is an inhibitor of a serine protease, neurotrypsin. Moreover, in the Cln1 (-/-) mice, suppression of neurotrypsin activity by serpina1 inhibited the cleavage of ..

More Information


  1. Rasulov A, Mamedli Z, Gordeyev S, Kozlov N, Dzhumabaev H. Short-term outcomes after transanal and laparoscopic total mesorectal excision for rectal cancer. Tech Coloproctol. 2016;20:227-34 pubmed publisher
    ..From October 2013 to January 2015, consecutive patients undergoing transanal or laparoscopic TME for biopsy-proven mrT1-4aN0-2M0 rectal cancer were included in a prospective database...
  2. Gschwend T, Krueger S, Kozlov S, Wolfer D, Sonderegger P. Neurotrypsin, a novel multidomain serine protease expressed in the nervous system. Mol Cell Neurosci. 1997;9:207-19 pubmed
    We have cloned a novel murine cDNA encoding a multidomain serine protease, termed neurotrypsin, which exhibits an unprecedented domain composition...
  3. Poorafshar M, Hellman L. Cloning and structural analysis of leydin, a novel human serine protease expressed by the Leydig cells of the testis. Eur J Biochem. 1999;261:244-50 pubmed
    ..We therefore propose the name leydin for this novel protease...
  4. Molinari F, Rio M, Meskenaite V, Encha Razavi F, Auge J, Bacq D, et al. Truncating neurotrypsin mutation in autosomal recessive nonsyndromic mental retardation. Science. 2002;298:1779-81 pubmed
    A 4-base pair deletion in the neuronal serine protease neurotrypsin gene was associated with autosomal recessive nonsyndromic mental retardation (MR)...
  5. Proba K, Gschwend T, Sonderegger P. Cloning and sequencing of the cDNA encoding human neurotrypsin. Biochim Biophys Acta. 1998;1396:143-7 pubmed
    cDNA clones encoding human neurotrypsin have been isolated from a human fetal brain cDNA library using a PCR-amplified probe...
  6. Kozlov S, Riegel M, Kinter J, Hintsch G, Cinelli P, Schinzel A, et al. Assignment of the gene encoding the neuronal multidomain serine protease neurotrypsin (PRSS12) to human chromosome band 4q25-->q26 by in situ hybridization. Cytogenet Cell Genet. 1999;84:107-8 pubmed