neurotrophin 3


Gene Symbol: neurotrophin 3
Description: neurotrophin 3
Alias: HDNF, NGF-2, NGF2, NT-3, NT3, neurotrophin-3, nerve growth factor 2, neurotrophic factor
Species: human
Products:     neurotrophin 3

Top Publications

  1. Nassenstein C, Braun A, Erpenbeck V, Lommatzsch M, Schmidt S, Krug N, et al. The neurotrophins nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 are survival and activation factors for eosinophils in patients with allergic bronchial asthma. J Exp Med. 2003;198:455-67 pubmed
    Neurotrophins (nerve growth factor [NGF], brain-derived neurotrophic factor [BDNF], neurotrophin [NT]-3, and NT-4) have been observed in elevated concentrations in allergic diseases...
  2. Kobayashi H, Gleich G, Butterfield J, Kita H. Human eosinophils produce neurotrophins and secrete nerve growth factor on immunologic stimuli. Blood. 2002;99:2214-20 pubmed
    ..Alternatively, eosinophils may play important roles in maintenance and restoration of homeostatic functions of mucosal tissues through the pleitropic activities of NGF. ..
  3. Groneberg D, Peiser C, Eynott P, Welker P, Erbes R, Witt C, et al. Transcriptional down-regulation of neurotrophin-3 in chronic obstructive pulmonary disease. Biol Chem. 2005;386:53-9 pubmed
    ..The present data on neurotrophin-specific transcriptional down-regulation of NT-3 in human COPD indicate a pathophysiological role for neurotrophins in COPD. ..
  4. Auer T, Xiao T, Bercier V, Gebhardt C, Duroure K, Concordet J, et al. Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3. elife. 2015;4: pubmed publisher
    ..Thus, our study has uncovered an activity-dependent, retrograde signaling pathway that homeostatically controls axonal branching. ..
  5. Vaughan S, Stanley O, Valdez G. Impact of Aging on Proprioceptive Sensory Neurons and Intrafusal Muscle Fibers in Mice. J Gerontol A Biol Sci Med Sci. 2017;72:771-779 pubmed publisher
    ..Our analysis also revealed normal levels of neurotrophin 3 (NT3) but dysregulated expression of the tyrosine kinase receptor C (TrkC) in aged muscles and DRGs, ..
  6. Lee I, Koo K, Jung K, Kim M, Kim I, Hwang K, et al. Neurogenin-2-transduced human neural progenitor cells attenuate neonatal hypoxic-ischemic brain injury. Transl Res. 2017;183:121-136.e9 pubmed publisher
    ..NEUROG2-NPCs showed increased secretion of multiple factors, such as nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 (NTF3), fibroblast growth factor 9 (FGF9), ciliary neurotrophic factor (CNTF), and ..
  7. Selim A, Selim S, Shalaby S, Mosaad H, Saber T. Neuroprotective effects of placenta-derived mesenchymal stromal cells in a rat model of experimental autoimmune encephalomyelitis. Cytotherapy. 2016;18:1100-13 pubmed publisher
    ..Moreover, there was an engraftment of the PDMSCs into the brain tissue. Human brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and neurotrophin 3 (NTF3) were significantly expressed in brains of rats ..
  8. Munir A, Hussain S, Dilshad E. Silver nanoparticles conjugated with Neurotrophin 3 upregulate myelin gene transcription pathway. J Theor Biol. 2018;459:111-118 pubmed publisher
    ..Modeling and simulation analysis was performed to determine the level of expression of several genes. The Neurotrophin 3 ligand-coated with silver nanoparticle was induced in the model to normalize the transcription of myelin gene...
  9. Hodyl N, Crawford T, McKerracher L, Lawrence A, Pitcher J, Stark M. Antenatal steroid exposure in the late preterm period is associated with reduced cord blood neurotrophin-3. Early Hum Dev. 2016;101:57-62 pubmed publisher
    ..Cord blood neurotrophin-3 (NT-3), NT-4, nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) concentrations measured by ELISA...

More Information

Publications192 found, 100 shown here

  1. Pandamooz S, Salehi M, Zibaii M, Ahmadiani A, Nabiuni M, Dargahi L. Epidermal neural crest stem cell-derived glia enhance neurotrophic elements in an ex vivo model of spinal cord injury. J Cell Biochem. 2017;: pubmed publisher
    ..Immunoblotting data demonstrated that the expression of GFAP, BDNF, neurotrophin-3 (NT3) and Bcl2 increased significantly in stem cell treated slices...
  2. Bocco B, Werneck de Castro J, Oliveira K, Fernandes G, Fonseca T, Nascimento B, et al. Type 2 Deiodinase Disruption in Astrocytes Results in Anxiety-Depressive-Like Behavior in Male Mice. Endocrinology. 2016;157:3682-95 pubmed publisher
    ..These findings suggest that defects in Dio2 expression in the brain could result in mood and behavioral disorders. ..
  3. Allard J, Perez E, Fukui K, Carpenter P, Ingram D, De Cabo R. Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice. Behav Brain Res. 2016;301:1-9 pubmed publisher
  4. Oliveira Fernandes M, Tourtellotte W. Egr3-dependent muscle spindle stretch receptor intrafusal muscle fiber differentiation and fusimotor innervation homeostasis. J Neurosci. 2015;35:5566-78 pubmed publisher
    ..However, they were not innervated by fusimotor axons and they did not express glial derived neurotrophic factor (GDNF), which is essential for fusimotor neuron survival...
  5. Venkatesan R, Shim W, Yeo E, Kim S. Lactucopicrin potentiates neuritogenesis and neurotrophic effects by regulating Ca2+/CaMKII/ATF1 signaling pathway. J Ethnopharmacol. 2017;198:174-183 pubmed publisher
    ..Additionally, the levels of neurotrophins including NGF, BDNF, and NT3 were increased by treatment of lactucopicrin in C6 cells...
  6. Huang Z, Zhao T, Wang N, Zheng S. Ectopic expression of Lc differentially regulated anthocyanin biosynthesis in the floral parts of tobacco (Nicotiana tobacum L.) plants. Bot Stud. 2016;57:24 pubmed publisher
    ..Ectopic expression of Lc greatly enhanced both early- and late- anthocyanin-biosynthetic gene expression, and therefore resulted in the Cya-based TAC increase in the calyxes, the filaments and the petals in tobacco plants. ..
  7. Yuan L, Li J, Zha J, Wang Z. Targeting neurotrophic factors and their receptors, but not cholinesterase or neurotransmitter, in the neurotoxicity of TDCPP in Chinese rare minnow adults (Gobiocypris rarus). Environ Pollut. 2016;208:670-7 pubmed publisher
    ..g., ntf3, ntrk1, ntrk2, ngfr, and fgf2, fgf11, fgf22, fgfr4), indicating that TDCPP or other OPFRs may elicit neurological effects by targeting neurotrophic factors and their receptors in Chinese rare minnow. ..
  8. Zhao Y, Wang Q, Jia M, Fu S, Pan J, Chu C, et al. (+)-Sesamin attenuates chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits via suppression of neuroinflammation. J Nutr Biochem. 2019;64:61-71 pubmed publisher
    ..of PSD-95 in stressed mice hippocampus with improving neurotrophic factors expression including BDNF and NT3. Moreover, sesamin treatment significantly prevented CUMS-induced neuroinflammation by inhibiting over-activation ..
  9. Soundara Rajan T, Scionti D, Diomede F, Piattelli A, Bramanti P, Mazzon E, et al. Prolonged Expansion Induces Spontaneous Neural Progenitor Differentiation from Human Gingiva-Derived Mesenchymal Stem Cells. Cell Reprogram. 2017;: pubmed publisher
    ..repressors TP53 and p21, whereas Western blot results revealed the expression of neurotrophic factors BDNF and NT3 at passage 41...
  10. Fabbri C, Serretti A. Genetics of long-term treatment outcome in bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2016;65:17-24 pubmed publisher
    ..Further studies focused on the outlined genes may be helpful to provide validated markers of BD treatment outcome. ..
  11. Hui S, Sheng D, Sugimoto K, González Rajal A, Nakagawa S, Hesselson D, et al. Zebrafish Regulatory T Cells Mediate Organ-Specific Regenerative Programs. Dev Cell. 2017;43:659-672.e5 pubmed publisher
    ..Our data delineate organ-specific roles for Treg cells in maintaining pro-regenerative capacity that could potentially be harnessed for diverse regenerative therapies. ..
  12. Takamatsu H, Yoroidaka T, Fujisawa M, Kobori K, Hanawa M, Yamashita T, et al. Comparison of minimal residual disease detection in multiple myeloma by SRL 8-color single-tube and EuroFlow 8-color 2-tube multiparameter flow cytometry. Int J Hematol. 2019;109:377-381 pubmed publisher
  13. Petzold S, Sommer B, Kröber A, Nitsch R, Schwegler H, Vogt J, et al. NT-3 protein levels are enhanced in the hippocampus of PRG1-deficient mice but remain unchanged in PRG1/LPA2 double mutants. Neurosci Lett. 2016;612:145-148 pubmed publisher
    ..This was normalized by additional LPA2R deletion, and we conclude the increased NT3-levels were directly or indirectly attributable to increased hippocampal network activity, possibly exerting a ..
  14. Ivanov I, Firth A, Michel A, Atkins J, Baranov P. Identification of evolutionarily conserved non-AUG-initiated N-terminal extensions in human coding sequences. Nucleic Acids Res. 2011;39:4220-34 pubmed publisher
    ..In several instances, we have been able to obtain independent experimental evidence of the expression of non-AUG-initiated products from the previously published literature and ribosome profiling data. ..
  15. Prasad A, Teh D, Blasiak A, Chai C, Wu Y, Gharibani P, et al. Static Magnetic Field Stimulation Enhances Oligodendrocyte Differentiation and Secretion of Neurotrophic Factors. Sci Rep. 2017;7:6743 pubmed publisher
    ..2 and CaV1.3. Our findings emphasize the ability of glial cells such as OPCs to positively respond to moderate intensity SMF stimulation by exhibiting enhanced differentiation, functionality as well as neurotrophic factor release.
  16. Jwo S, Chung I, Wang H, Chang T. Identifying the Growth Factors for Improving Neointestinal Regeneration in Rats through Transcriptome Analysis Using RNA-Seq Data. Biomed Res Int. 2018;2018:4037865 pubmed publisher
  17. Peng W, Zhu S, Wang J, Chen L, Weng J, Chen S. Lnc-NTF3-5 promotes osteogenic differentiation of maxillary sinus membrane stem cells via sponging miR-93-3p. Clin Implant Dent Relat Res. 2017;: pubmed publisher
    ..The function and the mechanism of long non-coding RNAs (lncRNAs) on the osteogenic differentiation of maxillary sinus membrane stem cells (MSMSCs) remain largely unknown...
  18. Wang Y, Wang J, Wang H, Feng X, Tao Y, Yang J, et al. Tet1 Overexpression and Decreased DNA Hydroxymethylation Protect Neurons Against Cell Death After Injury by Increasing Expression of Genes Involved in Cell Survival. World Neurosurg. 2019;: pubmed publisher
    ..Tet1 overexpression and demethylation caused by azacytidine protect neurons against cell death after injury by increasing expression of genes involved in cell survival. ..
  19. Nelius T, Martinez Marin D, Hirsch J, Miller B, Rinard K, Lopez J, et al. Pigment epithelium-derived factor expression prolongs survival and enhances the cytotoxicity of low-dose chemotherapy in castration-refractory prostate cancer. Cell Death Dis. 2014;5:e1210 pubmed publisher
    ..c. PC3 tumors that conditionally express PEDF anti-tumoral epitope/NT3. Although NT3-DTX-5 mg/kg combination was inefficient, NT3-DTX-1 mg/kg and -0.5 mg/kg inhibited by 95% and 87...
  20. Blondy S, Christou N, David V, Verdier M, Jauberteau M, Mathonnet M, et al. Neurotrophins and their involvement in digestive cancers. Cell Death Dis. 2019;10:123 pubmed publisher
    ..This review focuses on neurotrophins, including NGF, BDNF, and NT3, and their specific tyrosine kinase receptors called tropomyosin receptor kinase (Trk A, B, C, respectively), ..
  21. Hao P, Duan H, Hao F, Chen L, Sun M, Fan K, et al. Neural repair by NT3-chitosan via enhancement of endogenous neurogenesis after adult focal aspiration brain injury. Biomaterials. 2017;140:88-102 pubmed publisher
    ..Here we report a biodegradable material, chitosan, which, when loaded with neurotrophin-3 (NT3) and injected into the lesion site after TBI, effectively engaged endogenous NSCs to proliferate and migrate to the ..
  22. Krawczyk P, Twarog E, Kurowska E, Klopotowska D, Matuszyk J. Establishment of a cellular model to study TrkC-dependent neuritogenesis. In Vitro Cell Dev Biol Anim. 2015;51:241-8 pubmed publisher
    ..TrkA receptor binds and is activated mainly by NGF, while TrkC receptor binds and is activated by neurotrophin 3 (NT3)...
  23. Renno W, Khan K, Benov L. Is there a role for neurotrophic factors and their receptors in augmenting the neuroprotective effect of (-)-epigallocatechin-3-gallate treatment of sciatic nerve crush injury?. Neuropharmacology. 2016;102:1-20 pubmed publisher
    ..Analysis of BDNF, GDNF and NT3 neurotropic factors and Trk-B, Trk-C and NGFR-p75 receptors in neurons in the spinal cord of CRUSH and CRUSH +Â..
  24. Martiñón S, García Vences E, Toscano Tejeida D, Flores Romero A, Rodriguez Barrera R, Ferrusquia M, et al. Long-term production of BDNF and NT-3 induced by A91-immunization after spinal cord injury. BMC Neurosci. 2016;17:42 pubmed publisher
    ..In the first one, brain derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) concentrations were evaluated at the site of lesion 21 days after SC-..
  25. Pfingst B, Colesa D, Swiderski D, Hughes A, Strahl S, Sinan M, et al. Neurotrophin Gene Therapy in Deafened Ears with Cochlear Implants: Long-term Effects on Nerve Survival and Functional Measures. J Assoc Res Otolaryngol. 2017;18:731-750 pubmed publisher
    ..These measures should be applicable for assessing cochlear health in human subjects. ..
  26. Oudega M, Hao P, Shang J, Haggerty A, Wang Z, Sun J, et al. Validation study of neurotrophin-3-releasing chitosan facilitation of neural tissue generation in the severely injured adult rat spinal cord. Exp Neurol. 2019;312:51-62 pubmed publisher label rats that were randomly assigned into three experimental groups: transection with chitosan-NT-3 implant (C-NT3), transection only (T-controls), and laminectomy only (S-controls), blinding the experimenters to the treatments...
  27. Kemi C, Grunewald J, Eklund A, Höglund C. Differential regulation of neurotrophin expression in human bronchial smooth muscle cells. Respir Res. 2006;7:18 pubmed
    ..The neurotrophins, including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), have been shown to be elevated during airway inflammation and evoke ..
  28. Walz J, Andreazza A, Frey B, Cacilhas A, Ceresér K, Cunha A, et al. Serum neurotrophin-3 is increased during manic and depressive episodes in bipolar disorder. Neurosci Lett. 2007;415:87-9 pubmed
    ..001) and depressed (p<0.001) BD patients, as compared with euthymic patients and normal controls. These findings suggest that the NT-3 signaling system may play a role in the pathophysiology of BD. ..
  29. Dmitrzak Weglarz M, Skibinska M, Slopien A, Tyszkiewicz M, Pawlak J, Maciukiewicz M, et al. Serum neurotrophin concentrations in polish adolescent girls with anorexia nervosa. Neuropsychobiology. 2013;67:25-32 pubmed publisher
    Several lines of evidence suggest that brain-derived neurotrophic factor (BDNF) plays an important role in weight regulation and eating behaviors as well as in the activity-dependent neuroplasticity underlying learning and memory ..
  30. Canner J, Linsenmayer T, Kubilus J. Developmental regulation of trigeminal TRPA1 by the cornea. Invest Ophthalmol Vis Sci. 2014;56:29-36 pubmed publisher
    ..Similarly, the addition of exogenous neurotrophin-3 (NT3) protein to cultured ganglia increased the expression of TRPA1 more than 100-fold...
  31. Guo P, Zhu F, Liu Q, Zhang L, Li J, Huang Y, et al. A taxonomic revision of the Asian keelback snakes, genus Amphiesma (Serpentes: Colubridae: Natricinae), with description of a new species. Zootaxa. 2014;3873:425-40 pubmed publisher
    ..b) and three nuclear genes (C-mos, Rag1, NT3), sampling 18 species in addition to those sequenced in previous works...
  32. Martins L, Duarte H, Ferreira A, Rocha N, Teixeira A, Domingues R. Migraine is associated with altered levels of neurotrophins. Neurosci Lett. 2015;587:6-10 pubmed publisher
    ..We measured serum levels of neurotrophin family members - nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin 3 and 4/5 (NT3 and NT4/5) - and glial cell line-derived factor (GDNF) in patients ..
  33. Li X, Han J, Zhao Y, Ding W, Wei J, Li J, et al. Functionalized collagen scaffold implantation and cAMP administration collectively facilitate spinal cord regeneration. Acta Biomater. 2016;30:233-245 pubmed publisher
    ..proteins (CBD-EphA4LBD, CBD-PlexinB1LBD and NEP1-40) and collagen-binding neurotrophic factors (CBD-BDNF and CBD-NT3) to simultaneously antagonize myelin inhibitory molecules (ephrinB3, Sema4D and Nogo) and exert neurotrophic ..
  34. Rao J, Zhao C, Zhang A, Duan H, Hao P, Wei R, et al. NT3-chitosan enables de novo regeneration and functional recovery in monkeys after spinal cord injury. Proc Natl Acad Sci U S A. 2018;115:E5595-E5604 pubmed publisher
    ..We have previously shown that neurotrophin3 (NT3)-loaded chitosan biodegradable material allowed for prolonged slow release of NT3 for 14 weeks under physiological ..
  35. Pellegrino K, Brunes T, Souza S, Laguna M, Avila Pires T, Hoogmoed M, et al. On the distinctiveness of Amapasaurus, its relationship with Loxopholis Cope 1869, and description of a new genus for L. guianensis and L. hoogmoedi (Gymnophthalmoidea/Ecpleopodini: Squamata). Zootaxa. 2018;4441:332-346 pubmed publisher
    ..Here we add mitochondrial and nuclear sequence data (12S, cyt b, ND4, c-mos and NT3) of Amapasaurus to previously published and new data of all Ecpleopodini genera (except for Adercosaurus), in order ..
  36. Shen W, Chung S, Irhimeh M, Li S, Lee S, Gillies M. Systemic administration of erythropoietin inhibits retinopathy in RCS rats. PLoS ONE. 2014;9:e104759 pubmed publisher
    ..and microglia, photoreceptor apoptosis, differential expression of p75 neurotrophin receptor (p75NTR), pro-neurotrophin 3 (pro-NT3), tumour necrosis factor-α (TNFα), pigment epithelium derived factor (PEDF) and vascular ..
  37. Petrosyan H, Alessi V, Hunanyan A, Sisto S, Arvanian V. Spinal electro-magnetic stimulation combined with transgene delivery of neurotrophin NT-3 and exercise: novel combination therapy for spinal contusion injury. J Neurophysiol. 2015;114:2923-40 pubmed publisher
    ..alone and combined with exercise training and transgene delivery of neurotrophin [adeno-associated virus 10-neurotrophin 3 (AAV10-NT3)]...
  38. Liu Z, Liu X, Lu S, Yu A, Zhang Z. Effect of nicotine withdrawal on pain sensitivity in rats to mechanical stimulation and thermal stimulation. Eur Rev Med Pharmacol Sci. 2014;18:2759-65 pubmed
    ..6 rats in each group, including the control group, normal saline group (NS group), nicotine group of 3 mg/kg/d (NT3 group), nicotine group of 9 mg/kg/d (NT9 group) and nicotine group of 18 mg/kg/d (NT18 group)...
  39. Hui J, Le J, Katta V, Rosenfeld R, Rohde M, Haniu M. Human neurotrophin-3: a one-step peptide mapping method and complete disulfide characterization of the recombinant protein. J Protein Chem. 1996;15:351-8 pubmed
    ..This disulfide structure is homologous to the NGF family of neurotrophic factors. ..
  40. Maruccio L, Castaldo L, D ANGELO L, Gatta C, Lucini C, Cotea C, et al. Neurotrophins and specific receptors in the oviduct tracts of Japanese quail (Coturnix coturnix japonica). Ann Anat. 2016;207:38-46 pubmed publisher
    ..By immunohistochemistry we were able to define the distribution of NTs and Trks. Specifically, NGF, BDNF and NT3 were localized in lining and ductal epithelial cells, and NGF was also detected in secretory cells of tubular ..
  41. Coutinho de Almeida R, Ramos Y, Mahfouz A, den Hollander W, Lakenberg N, Houtman E, et al. RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage. Ann Rheum Dis. 2019;78:270-277 pubmed publisher
    ..Our functional data demonstrated interacting levels at which miRNA affects expression of genes in the cartilage and exemplified the complexity of functionally validating a network of genes that may be targeted by multiple miRNAs. ..
  42. Soppet D, Escandon E, Maragos J, Middlemas D, Reid S, Blair J, et al. The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Cell. 1991;65:895-903 pubmed
    ..Thus, the trk family of receptors are likely to be important signal transducers of NGF-related trophic signals in the formation and maintenance of neuronal circuits. ..
  43. Jin Y, Kondo K, Ushio M, Kaga K, Ryan A, Yamasoba T. Developmental changes in the responsiveness of rat spiral ganglion neurons to neurotrophic factors in dissociated culture: differential responses for survival, neuritogenesis and neuronal morphology. Cell Tissue Res. 2013;351:15-27 pubmed publisher
    ..the responsiveness of postnatal rat spiral ganglion neurons (SGNs) to neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF) and leukemia inhibitory factor (LIF) were examined by using a dissociated cell culture system...
  44. Robinson R, Radziejewski C, Stuart D, Jones E. Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer. Biochemistry. 1995;34:4139-46 pubmed
    ..The neurotrophins (nerve growth factor, NGF; brain-derived neurotrophic factor, BDNF; neurotrophin 3, NT3; and neurotrophin 4, NT4) are dimeric molecules which share approximately 50% ..
  45. Arnold S, Facer P, Yiangou Y, Chen M, Plumpton C, Tate S, et al. Decreased potassium channel IK1 and its regulator neurotrophin-3 (NT-3) in inflamed human bowel. Neuroreport. 2003;14:191-5 pubmed
    ..Our findings may explain the diarrhoea and colicky abdominal pain produced by inflammatory bowel disease, and by IK1-blocking pyridine drugs prescribed for neuromuscular disorders. ..
  46. Kersigo J, Fritzsch B. Inner ear hair cells deteriorate in mice engineered to have no or diminished innervation. Front Aging Neurosci. 2015;7:33 pubmed publisher
    ..Our data support a role of innervation for long-term maintenance but with a remarkable local variation that needs to be taken into account when attempting regeneration of the organ of Corti. ..
  47. Yang Z, Zhang A, Duan H, Zhang S, Hao P, Ye K, et al. NT3-chitosan elicits robust endogenous neurogenesis to enable functional recovery after spinal cord injury. Proc Natl Acad Sci U S A. 2015;112:13354-9 pubmed publisher
    ..Here we report that neurotrophin-3 (NT3)-coupled chitosan biomaterial, when inserted into a 5-mm gap of completely transected and excised rat thoracic ..
  48. Tom B, Witko J, LeMay M, Singh A. Effects of bioengineered scaffold loaded with neurotrophins and locomotor training in restoring H-reflex responses after spinal cord injury. Exp Brain Res. 2018;236:3077-3084 pubmed publisher
    ..received bioengineered scaffold poly N-isopropylacrylamide-g-poly ethylene glycol (PNIPAAm-g-PEG) loaded with BDNF/NT3 followed by body weight supported treadmill training (BWSTT) and assessed the efficacy of the combinational ..
  49. Tauris J, Gustafsen C, Christensen E, Jansen P, Nykjaer A, Nyengaard J, et al. Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons. Eur J Neurosci. 2011;33:622-31 pubmed publisher
    ..The NTs brain-derived nerve growth factor (BDNF) and NT3 provide essential trophic support to auditory neurons...
  50. Nakamura M, Tsuji O, Bregman B, Toyama Y, Okano H. Mimicking the neurotrophic factor profile of embryonic spinal cord controls the differentiation potential of spinal progenitors into neuronal cells. PLoS ONE. 2011;6:e20717 pubmed publisher
    ..Here we show that embryonic spinal cord derived-progenitor cells express both ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) mRNA before differentiation...
  51. Kobayashi N, Nagata T, Shinagawa S, Nakayama R, Kondo K, Nakayama K, et al. Association between neurotrophin-3 polymorphisms and executive function in Japanese patients with amnestic mild cognitive impairment and mild Alzheimer disease. Dement Geriatr Cogn Disord. 2012;34:190-7 pubmed publisher
    ..These results suggested that an NT-3 polymorphism, rs6332, may significantly influence executive function, reflecting interference performances among patients with mild-stage AD. ..
  52. Sun X, Chen B, Xia Y, Wang J, Chen L. Functional switch from pro-neurotrophins to mature neurotrophins. Curr Protein Pept Sci. 2013;14:617-25 pubmed
    ..g., nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin3 (NT3) can be synthesized, secreted from neurons or glial cells and function actively ..
  53. Duricki D, Hutson T, Kathe C, Soleman S, Gonzalez Carter D, Petruska J, et al. Delayed intramuscular human neurotrophin-3 improves recovery in adult and elderly rats after stroke. Brain. 2016;139:259-75 pubmed publisher
    ..We show here that intramuscular delivery of neurotrophin-3 (NT3, encoded by NTF3) can induce sensorimotor recovery when treatment is initiated 24 h after stroke...
  54. Kaisho Y, Yoshimura K, Nakahama K. Cloning and expression of a cDNA encoding a novel human neurotrophic factor. FEBS Lett. 1990;266:187-91 pubmed
    A cDNA encoding a novel human neurotrophic factor (designated nerve growth factor-2; NGF-2) was cloned from a human glioma cDNA library using a synthetic DNA corresponding to human nerve growth factor (NGF)...
  55. Hattori M, Kunugi H, Akahane A, Tanaka H, Ishida S, Hirose T, et al. Novel polymorphisms in the promoter region of the neurotrophin-3 gene and their associations with schizophrenia. Am J Med Genet. 2002;114:304-9 pubmed
    ..Our results suggest that the G(- 3004)-A3 haplotype has a modest effect of giving susceptibility to schizophrenia. ..
  56. Kindberg A, Bendriem R, Spivak C, Chen J, Handreck A, Lupica C, et al. An in vitro model of human neocortical development using pluripotent stem cells: cocaine-induced cytoarchitectural alterations. Dis Model Mech. 2014;7:1397-405 pubmed publisher
    ..the cerebral cortex formed after rosettes were seeded and cultured for 3 weeks in the presence of FGF18, BDNF and NT3. Neurons migrated along radial glia scaffolding, with deep-layer CTIP2(+) cortical neurons appearing after 1 week ..
  57. Tseng P, Chen Y, Tu K, Wang H, Chung W, Wu C, et al. State-dependent increase in the levels of neurotrophin-3 and neurotrophin-4/5 in patients with bipolar disorder: A meta-analysis. J Psychiatr Res. 2016;79:86-92 pubmed publisher
    ..Our results suggest a state-dependent increase in NT-3 and NT-4/5 levels in patients with BD. Further studies are needed to examine dynamic changes of these neurotrophins in BD patients along the disease course. ..
  58. Moradian H, Keshvari H, Fasehee H, Dinarvand R, Faghihi S. Combining NT3-overexpressing MSCs and PLGA microcarriers for brain tissue engineering: A potential tool for treatment of Parkinson's disease. Mater Sci Eng C Mater Biol Appl. 2017;76:934-943 pubmed publisher
    ..Our approach that sustains presence of growth factor can be suggested as a novel complementary therapeutic strategy for treatment of Parkinson disease. ..
  59. Wu D, Zhang Y, Xu X, Guo T, Xie D, Zhu R, et al. RGD/TAT-functionalized chitosan-graft-PEI-PEG gene nanovector for sustained delivery of NT-3 for potential application in neural regeneration. Acta Biomater. 2018;72:266-277 pubmed publisher
    ..Therefore, our study provided an effective strategy for producing neurotrophins by engineering cells with gene delivery, which deserved wide investigation and potential application in regenerative medicine. ..
  60. Mahmood E, Jeganathan J, Feng R, Saraf M, Khabbaz K, Mahmood F, et al. Decreased PGC-1α Post-Cardiopulmonary Bypass Leads to Impaired Oxidative Stress in Diabetic Patients. Ann Thorac Surg. 2019;107:467-476 pubmed publisher
    ..01 and 0.0018, respectively). Antioxidant markers (NOX4 and GPX4), angiogenic factors (TGF-β, NT3, and Ang1), and the antiapoptotic factor BCL-xL were significantly lower in diabetic patients after CPB (p < 0...
  61. Syed Z, Dudbridge F, Kent L. An investigation of the neurotrophic factor genes GDNF, NGF, and NT3 in susceptibility to ADHD. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:375-8 pubmed
    ..Glial derived neurotrophic factor (GDNF), nerve growth factor (NGF (beta subunit)), and neurotrophic factor 3 (NT3) are members of the ..
  62. Hickman F, Stanley E, Carter B. Neurotrophin Responsiveness of Sympathetic Neurons Is Regulated by Rapid Mobilization of the p75 Receptor to the Cell Surface through TrkA Activation of Arf6. J Neurosci. 2018;38:5606-5619 pubmed publisher
    ..p75NTR is expressed at low levels as sympathetic axons project toward their targets, which enables neurotrophin-3 (NT3) to activate TrkA receptors and promote growth...
  63. Kalinowska Łyszczarz A, Pawlak M, Michalak S, Paprzycki W, Losy J. Immune cell NT-3 expression is associated with brain atrophy in multiple sclerosis patients. J Neuroimmunol. 2011;240-241:109-13 pubmed publisher
    ..Thus, PBMC-derived neurotrophin-3 might exert a direct or indirect neuroprotective effect in MS. ..
  64. Bilgic A, Toker A, Isik U, Kilinc I. Serum brain-derived neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 levels in children with attention-deficit/hyperactivity disorder. Eur Child Adolesc Psychiatry. 2017;26:355-363 pubmed publisher
    ..This study aimed to investigate whether there are differences in serum brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and neurotrophin-3 (NTF3) ..
  65. Mentis G, Alvarez F, Shneider N, Siembab V, O Donovan M. Mechanisms regulating the specificity and strength of muscle afferent inputs in the spinal cord. Ann N Y Acad Sci. 2010;1198:220-30 pubmed publisher
    ..Several mutants were examined to establish the role of muscle spindles, muscle spindle-derived NT3, and excess NT3 in determining the specificity and strength of these connections...
  66. Ye Y, Feng T, Peng Y, Hu S, Xu T. The treatment of spinal cord injury in rats using bone marrow-derived neural-like cells induced by cerebrospinal fluid. Neurosci Lett. 2018;666:85-91 pubmed publisher
    ..Transplanting BMSC-Ns or BMSCs into the lateral ventricles improved the neurological function of rats with SCI. Moreover, BMSC-Ns were significantly more effective than BMSCs, which provides a possible approach for the treatment of SCI. ..
  67. Wan G, Gómez Casati M, Gigliello A, Liberman M, Corfas G. Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma. elife. 2014;3: pubmed publisher
    Neurotrophin-3 (Ntf3) and brain derived neurotrophic factor (Bdnf) are critical for sensory neuron survival and establishment of neuronal projections to sensory epithelia in the embryonic inner ear, but their postnatal functions remain ..
  68. Segura M, Pedreño C, Obiols J, Taurines R, Pàmias M, Grunblatt E, et al. Neurotrophin blood-based gene expression and social cognition analysis in patients with autism spectrum disorder. Neurogenetics. 2015;16:123-31 pubmed publisher
    ..The mRNA expression of neurotrophins (BDNF, NT3 and NT4) and their receptors (TrkA, TrkB and p75 (NTR) ) was determined by quantitative real-time polymerase chain ..
  69. Augustine J, Pavlou S, O Hare M, Harkin K, Stitt A, Curtis T, et al. Characterization of a Spontaneously Immortalized Murine Müller Glial Cell Line QMMuC-1. Invest Ophthalmol Vis Sci. 2018;59:1666-1674 pubmed publisher
    ..VEGFA, and glutamate aspartate transporter (GLAST), but lower levels of interleukin 6 (IL-6), brain-derived neurotrophic factor (BDNF), insulin-like growth factor 1 (IGF1), and neurotrophin 3 (NTF3)...
  70. Cho S, Kim H, Kim B, Kim J, Shin M, Cho D, et al. Neurotrophin-3 gene, intelligence, and selective attention deficit in a Korean sample with attention-deficit/hyperactivity disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34:1065-9 pubmed publisher
    ..021). These results provide preliminary evidence of an association between NTF3 and the intelligence and selective attention deficit in the Korean population. ..
  71. Lee M, Kurioka T, Nelson M, Prieskorn D, Swiderski D, Takada Y, et al. Viral-mediated Ntf3 overexpression disrupts innervation and hearing in nondeafened guinea pig cochleae. Mol Ther Methods Clin Dev. 2016;3:16052 pubmed publisher
    ..Experiments using transgenic mice have shown that overexpression of NT3 by supporting cells repairs synaptopathy caused by overstimulation...
  72. Üçeyler N, Riediger N, Kafke W, Sommer C. Differential gene expression of cytokines and neurotrophic factors in nerve and skin of patients with peripheral neuropathies. J Neurol. 2015;262:203-12 pubmed publisher
    Pathophysiologically relevant alterations in cytokine and neurotrophic factor levels have been reported in neuropathy subtypes...
  73. Liu H, Yin W, Liu B, Liu Y, Guo B, Wei Z. Screening of candidate genes in fibroblasts derived from patients with Dupuytren's contracture using bioinformatics analysis. Rheumatol Int. 2015;35:1343-50 pubmed publisher
    ..Only ten DC-associated genes, such as neurotrophin 3 (NTF3) and protein kinase C, epsilon (PRKCE), were further screened...
  74. Ricci A, Graziano P, Bronzetti E, Saltini C, Sciacchitano S, Cherubini E, et al. Increased pulmonary neurotrophin protein expression in idiopathic interstitial pneumonias. Sarcoidosis Vasc Diffuse Lung Dis. 2007;24:13-23 pubmed
    ..The neurotrophins (NTs) nerve growth factor (NGF), brain derived neurotrophic factor (BDNF) and NT-3, beside their importance in nervous, endocrine and immune system activities, participate in ..
  75. Park S, Kang M, Han J. Interleukin-1 beta promotes neuronal differentiation through the Wnt5a/RhoA/JNK pathway in cortical neural precursor cells. Mol Brain. 2018;11:39 pubmed publisher
    ..We showed that stimulation with IL-1β increased expression levels of neurotrophin-3 (NT3) and neurogenin 1 (Ngn1) and promoted neurite outgrowth...
  76. Wise A, Tu T, Atkinson P, Flynn B, Sgro B, Hume C, et al. The effect of deafness duration on neurotrophin gene therapy for spiral ganglion neuron protection. Hear Res. 2011;278:69-76 pubmed publisher
    ..Adenoviral vectors containing green fluorescent protein (GFP) with or without genes for Brain Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT3) were injected into the scala media (SM) compartment of cochleae that had ..
  77. Yamamuro T, Ohta H, Aoyama M, Watanabe D. Simultaneous determination of neonicotinoid insecticides in human serum and urine using diatomaceous earth-assisted extraction and liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2014;969:85-94 pubmed publisher
    ..A diatomaceous earth-assisted extraction using Extrelut NT3 column with chloroform/2-propanol (3:1, v/v) as eluent was selected for the single step cleanup procedure for all ..
  78. Tang Schomer M. 3D axon growth by exogenous electrical stimulus and soluble factors. Brain Res. 2018;1678:288-296 pubmed publisher
    ..significantly greater axon initial length increases compared to neurotrophic factors, such as BDNF, GDNF, NGF and NT3 (all at 1??M)...
  79. Hallbook F, Ibanez C, Persson H. Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. Neuron. 1991;6:845-58 pubmed
    ..Northern blot analysis of different tissues from Xenopus showed NT-4 mRNA only in ovary, where it was present at levels over 100-fold higher than those of NGF mRNA in heart. ..
  80. Lin P, Tsai G. Meta-analyses of the association between genetic polymorphisms of neurotrophic factors and schizophrenia. Schizophr Res. 2004;71:353-60 pubmed
    ..method to study the association of schizophrenia with the polymorphisms in two candidate genes, ciliary neurotrophic factor (CNTF) and neurotrophin 3 (NT3). In our study, two meta-analyses were performed...
  81. Reed Geaghan E, Wright M, See L, Adelman P, Lee K, Koerber H, et al. Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes. J Neurosci. 2016;36:4362-76 pubmed publisher
    ..We also show that this process is controlled by BDNF signaling. These findings provide new insights into the regulation of somatosensory neuron development and reveal a novel way in which Merkel cells participate in mechanosensation. ..
  82. Park S, Kang M, Han J. Neuronal NOS Induces Neuronal Differentiation Through a PKC?-Dependent GSK3? Inactivation Pathway in Hippocampal Neural Progenitor Cells. Mol Neurobiol. 2017;54:5646-5656 pubmed publisher
    ..and nNOS expression increased markedly during neuronal differentiation as did the expression of neurotrophin-3 (NT3), neurotrophin-4/5 (NT 4/5), and synapsin I...
  83. Vellosillo L, Muñoz M, Paíno C. Adipose tissue-derived stromal cells (ADSC) express oligodendrocyte and myelin markers, but they do not function as oligodendrocytes. Histochem Cell Biol. 2017;148:503-515 pubmed publisher
    ..treated with combinations of factors commonly used in neural-inducing media (retinoic acid, dbcAMP, EGF, basic FGF, NT3, and/or PDGF), the number of O1-positive cells changed, but in no case, mRNA expression of Sox10 and Olig2 ..
  84. Ribases M, Hervas A, Ramos Quiroga J, Bosch R, Bielsa A, Gastaminza X, et al. Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder. Biol Psychiatry. 2008;63:935-45 pubmed publisher
  85. Dedoni S, Olianas M, Ingianni A, Onali P. Interferon-? Inhibits Neurotrophin 3 Signalling and Pro-Survival Activity by Upregulating the Expression of Truncated TrkC-T1 Receptor. Mol Neurobiol. 2017;54:1825-1843 pubmed publisher
    ..As neurotrophin 3 (NT3) plays a critical role in neuroprotection, we examined the effects of IFN-? on the signalling and ..
  86. Rost B, Hanf G, Ohnemus U, Otto Knapp R, Groneberg D, Kunkel G, et al. Monocytes of allergics and non-allergics produce, store and release the neurotrophins NGF, BDNF and NT-3. Regul Pept. 2005;124:19-25 pubmed
    ..Cell stimulation with LPS leads to release of NGF and NT3. Monocytes, produce, store and release NGF, BDNF and NT-3...
  87. Truzzi F, Marconi A, Lotti R, Dallaglio K, French L, Hempstead B, et al. Neurotrophins and their receptors stimulate melanoma cell proliferation and migration. J Invest Dermatol. 2008;128:2031-40 pubmed publisher
    ..These results indicate that NTs, through their receptors, play a critical role in the progression of melanoma. ..
  88. Duan H, Ge W, Zhang A, Xi Y, Chen Z, Luo D, et al. Transcriptome analyses reveal molecular mechanisms underlying functional recovery after spinal cord injury. Proc Natl Acad Sci U S A. 2015;112:13360-5 pubmed publisher
    ..We discovered that neurotrophin-3 (NT3)-loaded chitosan provided an excellent microenvironment to facilitate nerve growth, new neurogenesis, and ..
  89. Mizsei E, Jablonski D, Roussos S, Dimaki M, Ioannidis Y, Nilson G, et al. Nuclear markers support the mitochondrial phylogeny of <i>Vipera</i> <i>ursinii-renardi</i> complex (Squamata: Viperidae) and species status for the Greek meadow viper. Zootaxa. 2017;4227:zootaxa.4227.1.4 pubmed publisher
    ..We present here new analyses of three nuclear markers (BDNF, NT3, PRLR; a first for studies of meadow and steppe vipers) as well as analyses of newly obtained mitochondrial DNA ..
  90. Qiao X, Yin F, Ji Y, Li Y, Yan P, Lai J. 5-Aza-2'-deoxycytidine in the medial prefrontal cortex regulates alcohol-related behavior and Ntf3-TrkC expression in rats. PLoS ONE. 2017;12:e0179469 pubmed publisher
    ..We also provide novel evidence for DNA methyltransferases as potential therapeutic targets in alcohol abuse. ..
  91. Almutiri S, Berry M, Logan A, Ahmed Z. Non-viral-mediated suppression of AMIGO3 promotes disinhibited NT3-mediated regeneration of spinal cord dorsal column axons. Sci Rep. 2018;8:10707 pubmed publisher
    ..A bicistronic plasmid, containing both shAMIGO3 and NT3 knocked down >75% of AMIGO3 mRNA in cultured DRGN and significantly overexpressed NT3 production...
  92. Barski J, Helbig C, Meyer M. Partial rescue of NT-3 null mutant phenotype by a PDGF-? regulated transgene. Neurosci Lett. 2011;501:179-84 pubmed publisher
    ..Mice carrying one or two PDGF-NT3 transgenes on a background null for wildtype NT-3 were generated by crossing with an NT-3 null strain...