neurotrophin 3

Summary

Gene Symbol: neurotrophin 3
Description: neurotrophin 3
Alias: HDNF, NGF-2, NGF2, NT-3, NT3, neurotrophin-3, nerve growth factor 2, neurotrophic factor
Species: human
Products:     neurotrophin 3

Top Publications

  1. Nassenstein C, Braun A, Erpenbeck V, Lommatzsch M, Schmidt S, Krug N, et al. The neurotrophins nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 are survival and activation factors for eosinophils in patients with allergic bronchial asthma. J Exp Med. 2003;198:455-67 pubmed
    Neurotrophins (nerve growth factor [NGF], brain-derived neurotrophic factor [BDNF], neurotrophin [NT]-3, and NT-4) have been observed in elevated concentrations in allergic diseases...
  2. Kobayashi H, Gleich G, Butterfield J, Kita H. Human eosinophils produce neurotrophins and secrete nerve growth factor on immunologic stimuli. Blood. 2002;99:2214-20 pubmed
    ..Alternatively, eosinophils may play important roles in maintenance and restoration of homeostatic functions of mucosal tissues through the pleitropic activities of NGF. ..
  3. Groneberg D, Peiser C, Eynott P, Welker P, Erbes R, Witt C, et al. Transcriptional down-regulation of neurotrophin-3 in chronic obstructive pulmonary disease. Biol Chem. 2005;386:53-9 pubmed
    ..The present data on neurotrophin-specific transcriptional down-regulation of NT-3 in human COPD indicate a pathophysiological role for neurotrophins in COPD. ..
  4. Bocco B, Werneck de Castro J, Oliveira K, Fernandes G, Fonseca T, Nascimento B, et al. Type 2 Deiodinase Disruption in Astrocytes Results in Anxiety-Depressive-Like Behavior in Male Mice. Endocrinology. 2016;157:3682-95 pubmed publisher
    ..These findings suggest that defects in Dio2 expression in the brain could result in mood and behavioral disorders. ..
  5. Yuan L, Li J, Zha J, Wang Z. Targeting neurotrophic factors and their receptors, but not cholinesterase or neurotransmitter, in the neurotoxicity of TDCPP in Chinese rare minnow adults (Gobiocypris rarus). Environ Pollut. 2016;208:670-7 pubmed publisher
    ..g., ntf3, ntrk1, ntrk2, ngfr, and fgf2, fgf11, fgf22, fgfr4), indicating that TDCPP or other OPFRs may elicit neurological effects by targeting neurotrophic factors and their receptors in Chinese rare minnow. ..
  6. Petzold S, Sommer B, Kröber A, Nitsch R, Schwegler H, Vogt J, et al. NT-3 protein levels are enhanced in the hippocampus of PRG1-deficient mice but remain unchanged in PRG1/LPA2 double mutants. Neurosci Lett. 2016;612:145-148 pubmed publisher
    ..This was normalized by additional LPA2R deletion, and we conclude the increased NT3-levels were directly or indirectly attributable to increased hippocampal network activity, possibly exerting a ..
  7. Syed Z, Dudbridge F, Kent L. An investigation of the neurotrophic factor genes GDNF, NGF, and NT3 in susceptibility to ADHD. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:375-8 pubmed
    ..Glial derived neurotrophic factor (GDNF), nerve growth factor (NGF (beta subunit)), and neurotrophic factor 3 (NT3) are members of the ..
  8. Soundara Rajan T, Scionti D, Diomede F, Piattelli A, Bramanti P, Mazzon E, et al. Prolonged Expansion Induces Spontaneous Neural Progenitor Differentiation from Human Gingiva-Derived Mesenchymal Stem Cells. Cell Reprogram. 2017;: pubmed publisher
    ..repressors TP53 and p21, whereas Western blot results revealed the expression of neurotrophic factors BDNF and NT3 at passage 41...
  9. Hickman F, Stanley E, Carter B. Neurotrophin Responsiveness of Sympathetic Neurons Is Regulated by Rapid Mobilization of the p75 Receptor to the Cell Surface through TrkA Activation of Arf6. J Neurosci. 2018;38:5606-5619 pubmed publisher
    ..p75NTR is expressed at low levels as sympathetic axons project toward their targets, which enables neurotrophin-3 (NT3) to activate TrkA receptors and promote growth...

More Information

Publications140 found, 100 shown here

  1. Kalinowska Łyszczarz A, Pawlak M, Michalak S, Paprzycki W, Losy J. Immune cell NT-3 expression is associated with brain atrophy in multiple sclerosis patients. J Neuroimmunol. 2011;240-241:109-13 pubmed publisher
    ..Thus, PBMC-derived neurotrophin-3 might exert a direct or indirect neuroprotective effect in MS. ..
  2. Bilgic A, Toker A, Isik U, Kilinc I. Serum brain-derived neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 levels in children with attention-deficit/hyperactivity disorder. Eur Child Adolesc Psychiatry. 2017;26:355-363 pubmed publisher
    ..This study aimed to investigate whether there are differences in serum brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and neurotrophin-3 (NTF3) ..
  3. Mentis G, Alvarez F, Shneider N, Siembab V, O Donovan M. Mechanisms regulating the specificity and strength of muscle afferent inputs in the spinal cord. Ann N Y Acad Sci. 2010;1198:220-30 pubmed publisher
    ..Several mutants were examined to establish the role of muscle spindles, muscle spindle-derived NT3, and excess NT3 in determining the specificity and strength of these connections...
  4. Ye Y, Feng T, Peng Y, Hu S, Xu T. The treatment of spinal cord injury in rats using bone marrow-derived neural-like cells induced by cerebrospinal fluid. Neurosci Lett. 2018;666:85-91 pubmed publisher
    ..Transplanting BMSC-Ns or BMSCs into the lateral ventricles improved the neurological function of rats with SCI. Moreover, BMSC-Ns were significantly more effective than BMSCs, which provides a possible approach for the treatment of SCI. ..
  5. Wan G, Gómez Casati M, Gigliello A, Liberman M, Corfas G. Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma. elife. 2014;3: pubmed publisher
    Neurotrophin-3 (Ntf3) and brain derived neurotrophic factor (Bdnf) are critical for sensory neuron survival and establishment of neuronal projections to sensory epithelia in the embryonic inner ear, but their postnatal functions remain ..
  6. Segura M, Pedreño C, Obiols J, Taurines R, Pàmias M, Grunblatt E, et al. Neurotrophin blood-based gene expression and social cognition analysis in patients with autism spectrum disorder. Neurogenetics. 2015;16:123-31 pubmed publisher
    ..The mRNA expression of neurotrophins (BDNF, NT3 and NT4) and their receptors (TrkA, TrkB and p75 (NTR) ) was determined by quantitative real-time polymerase chain ..
  7. Augustine J, Pavlou S, O Hare M, Harkin K, Stitt A, Curtis T, et al. Characterization of a Spontaneously Immortalized Murine Müller Glial Cell Line QMMuC-1. Invest Ophthalmol Vis Sci. 2018;59:1666-1674 pubmed publisher
    ..VEGFA, and glutamate aspartate transporter (GLAST), but lower levels of interleukin 6 (IL-6), brain-derived neurotrophic factor (BDNF), insulin-like growth factor 1 (IGF1), and neurotrophin 3 (NTF3)...
  8. Cho S, Kim H, Kim B, Kim J, Shin M, Cho D, et al. Neurotrophin-3 gene, intelligence, and selective attention deficit in a Korean sample with attention-deficit/hyperactivity disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34:1065-9 pubmed publisher
    ..021). These results provide preliminary evidence of an association between NTF3 and the intelligence and selective attention deficit in the Korean population. ..
  9. Lee M, Kurioka T, Nelson M, Prieskorn D, Swiderski D, Takada Y, et al. Viral-mediated Ntf3 overexpression disrupts innervation and hearing in nondeafened guinea pig cochleae. Mol Ther Methods Clin Dev. 2016;3:16052 pubmed publisher
    ..Experiments using transgenic mice have shown that overexpression of NT3 by supporting cells repairs synaptopathy caused by overstimulation...
  10. Üçeyler N, Riediger N, Kafke W, Sommer C. Differential gene expression of cytokines and neurotrophic factors in nerve and skin of patients with peripheral neuropathies. J Neurol. 2015;262:203-12 pubmed publisher
    Pathophysiologically relevant alterations in cytokine and neurotrophic factor levels have been reported in neuropathy subtypes...
  11. Liu H, Yin W, Liu B, Liu Y, Guo B, Wei Z. Screening of candidate genes in fibroblasts derived from patients with Dupuytren's contracture using bioinformatics analysis. Rheumatol Int. 2015;35:1343-50 pubmed publisher
    ..Only ten DC-associated genes, such as neurotrophin 3 (NTF3) and protein kinase C, epsilon (PRKCE), were further screened...
  12. Huang Z, Zhao T, Wang N, Zheng S. Ectopic expression of Lc differentially regulated anthocyanin biosynthesis in the floral parts of tobacco (Nicotiana tobacum L.) plants. Bot Stud. 2016;57:24 pubmed publisher
    ..Ectopic expression of Lc greatly enhanced both early- and late- anthocyanin-biosynthetic gene expression, and therefore resulted in the Cya-based TAC increase in the calyxes, the filaments and the petals in tobacco plants. ..
  13. Ricci A, Graziano P, Bronzetti E, Saltini C, Sciacchitano S, Cherubini E, et al. Increased pulmonary neurotrophin protein expression in idiopathic interstitial pneumonias. Sarcoidosis Vasc Diffuse Lung Dis. 2007;24:13-23 pubmed
    ..The neurotrophins (NTs) nerve growth factor (NGF), brain derived neurotrophic factor (BDNF) and NT-3, beside their importance in nervous, endocrine and immune system activities, participate in ..
  14. Park S, Kang M, Han J. Interleukin-1 beta promotes neuronal differentiation through the Wnt5a/RhoA/JNK pathway in cortical neural precursor cells. Mol Brain. 2018;11:39 pubmed publisher
    ..We showed that stimulation with IL-1? increased expression levels of neurotrophin-3 (NT3) and neurogenin 1 (Ngn1) and promoted neurite outgrowth...
  15. Wise A, Tu T, Atkinson P, Flynn B, Sgro B, Hume C, et al. The effect of deafness duration on neurotrophin gene therapy for spiral ganglion neuron protection. Hear Res. 2011;278:69-76 pubmed publisher
    ..Adenoviral vectors containing green fluorescent protein (GFP) with or without genes for Brain Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT3) were injected into the scala media (SM) compartment of cochleae that had ..
  16. Yamamuro T, Ohta H, Aoyama M, Watanabe D. Simultaneous determination of neonicotinoid insecticides in human serum and urine using diatomaceous earth-assisted extraction and liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2014;969:85-94 pubmed publisher
    ..A diatomaceous earth-assisted extraction using Extrelut NT3 column with chloroform/2-propanol (3:1, v/v) as eluent was selected for the single step cleanup procedure for all ..
  17. Tang Schomer M. 3D axon growth by exogenous electrical stimulus and soluble factors. Brain Res. 2018;1678:288-296 pubmed publisher
    ..significantly greater axon initial length increases compared to neurotrophic factors, such as BDNF, GDNF, NGF and NT3 (all at 1??M)...
  18. Hallbook F, Ibanez C, Persson H. Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. Neuron. 1991;6:845-58 pubmed
    ..Northern blot analysis of different tissues from Xenopus showed NT-4 mRNA only in ovary, where it was present at levels over 100-fold higher than those of NGF mRNA in heart. ..
  19. Lin P, Tsai G. Meta-analyses of the association between genetic polymorphisms of neurotrophic factors and schizophrenia. Schizophr Res. 2004;71:353-60 pubmed
    ..method to study the association of schizophrenia with the polymorphisms in two candidate genes, ciliary neurotrophic factor (CNTF) and neurotrophin 3 (NT3). In our study, two meta-analyses were performed...
  20. Reed Geaghan E, Wright M, See L, Adelman P, Lee K, Koerber H, et al. Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes. J Neurosci. 2016;36:4362-76 pubmed publisher
    ..We also show that this process is controlled by BDNF signaling. These findings provide new insights into the regulation of somatosensory neuron development and reveal a novel way in which Merkel cells participate in mechanosensation. ..
  21. Park S, Kang M, Han J. Neuronal NOS Induces Neuronal Differentiation Through a PKC?-Dependent GSK3? Inactivation Pathway in Hippocampal Neural Progenitor Cells. Mol Neurobiol. 2017;54:5646-5656 pubmed publisher
    ..and nNOS expression increased markedly during neuronal differentiation as did the expression of neurotrophin-3 (NT3), neurotrophin-4/5 (NT 4/5), and synapsin I...
  22. Vellosillo L, Muñoz M, Paíno C. Adipose tissue-derived stromal cells (ADSC) express oligodendrocyte and myelin markers, but they do not function as oligodendrocytes. Histochem Cell Biol. 2017;148:503-515 pubmed publisher
    ..treated with combinations of factors commonly used in neural-inducing media (retinoic acid, dbcAMP, EGF, basic FGF, NT3, and/or PDGF), the number of O1-positive cells changed, but in no case, mRNA expression of Sox10 and Olig2 ..
  23. Peng W, Zhu S, Wang J, Chen L, Weng J, Chen S. Lnc-NTF3-5 promotes osteogenic differentiation of maxillary sinus membrane stem cells via sponging miR-93-3p. Clin Implant Dent Relat Res. 2017;: pubmed publisher
    ..The function and the mechanism of long non-coding RNAs (lncRNAs) on the osteogenic differentiation of maxillary sinus membrane stem cells (MSMSCs) remain largely unknown...
  24. Ribases M, Hervas A, Ramos Quiroga J, Bosch R, Bielsa A, Gastaminza X, et al. Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder. Biol Psychiatry. 2008;63:935-45 pubmed publisher
  25. Dedoni S, Olianas M, Ingianni A, Onali P. Interferon-? Inhibits Neurotrophin 3 Signalling and Pro-Survival Activity by Upregulating the Expression of Truncated TrkC-T1 Receptor. Mol Neurobiol. 2017;54:1825-1843 pubmed publisher
    ..As neurotrophin 3 (NT3) plays a critical role in neuroprotection, we examined the effects of IFN-? on the signalling and ..
  26. Rost B, Hanf G, Ohnemus U, Otto Knapp R, Groneberg D, Kunkel G, et al. Monocytes of allergics and non-allergics produce, store and release the neurotrophins NGF, BDNF and NT-3. Regul Pept. 2005;124:19-25 pubmed
    ..Cell stimulation with LPS leads to release of NGF and NT3. Monocytes, produce, store and release NGF, BDNF and NT-3...
  27. Truzzi F, Marconi A, Lotti R, Dallaglio K, French L, Hempstead B, et al. Neurotrophins and their receptors stimulate melanoma cell proliferation and migration. J Invest Dermatol. 2008;128:2031-40 pubmed publisher
    ..These results indicate that NTs, through their receptors, play a critical role in the progression of melanoma. ..
  28. Duan H, Ge W, Zhang A, Xi Y, Chen Z, Luo D, et al. Transcriptome analyses reveal molecular mechanisms underlying functional recovery after spinal cord injury. Proc Natl Acad Sci U S A. 2015;112:13360-5 pubmed publisher
    ..We discovered that neurotrophin-3 (NT3)-loaded chitosan provided an excellent microenvironment to facilitate nerve growth, new neurogenesis, and ..
  29. Mizsei E, Jablonski D, Roussos S, Dimaki M, Ioannidis Y, Nilson G, et al. Nuclear markers support the mitochondrial phylogeny of <i>Vipera</i> <i>ursinii-renardi</i> complex (Squamata: Viperidae) and species status for the Greek meadow viper. Zootaxa. 2017;4227:zootaxa.4227.1.4 pubmed publisher
    ..We present here new analyses of three nuclear markers (BDNF, NT3, PRLR; a first for studies of meadow and steppe vipers) as well as analyses of newly obtained mitochondrial DNA ..
  30. Qiao X, Yin F, Ji Y, Li Y, Yan P, Lai J. 5-Aza-2'-deoxycytidine in the medial prefrontal cortex regulates alcohol-related behavior and Ntf3-TrkC expression in rats. PLoS ONE. 2017;12:e0179469 pubmed publisher
    ..We also provide novel evidence for DNA methyltransferases as potential therapeutic targets in alcohol abuse. ..
  31. Almutiri S, Berry M, Logan A, Ahmed Z. Non-viral-mediated suppression of AMIGO3 promotes disinhibited NT3-mediated regeneration of spinal cord dorsal column axons. Sci Rep. 2018;8:10707 pubmed publisher
    ..A bicistronic plasmid, containing both shAMIGO3 and NT3 knocked down >75% of AMIGO3 mRNA in cultured DRGN and significantly overexpressed NT3 production...
  32. Venkatesan R, Shim W, Yeo E, Kim S. Lactucopicrin potentiates neuritogenesis and neurotrophic effects by regulating Ca2+/CaMKII/ATF1 signaling pathway. J Ethnopharmacol. 2017;198:174-183 pubmed publisher
    ..Additionally, the levels of neurotrophins including NGF, BDNF, and NT3 were increased by treatment of lactucopicrin in C6 cells...
  33. Barski J, Helbig C, Meyer M. Partial rescue of NT-3 null mutant phenotype by a PDGF-? regulated transgene. Neurosci Lett. 2011;501:179-84 pubmed publisher
    ..Mice carrying one or two PDGF-NT3 transgenes on a background null for wildtype NT-3 were generated by crossing with an NT-3 null strain...
  34. Lawn S, Krishna N, Pisklakova A, Qu X, Fenstermacher D, Fournier M, et al. Neurotrophin signaling via TrkB and TrkC receptors promotes the growth of brain tumor-initiating cells. J Biol Chem. 2015;290:3814-24 pubmed publisher
    ..express the neurotrophin receptors TrkB and TrkC, not TrkA, and they also express neurotrophins NGF, BDNF, and neurotrophin 3 (NT3)...
  35. Wang Y, Feng G, Xia Q, Hu Y, Xu Y, Xiong L, et al. Knockdown of α-synuclein in cerebral cortex improves neural behavior associated with apoptotic inhibition and neurotrophin expression in spinal cord transected rats. Apoptosis. 2016;21:404-20 pubmed publisher
    ..SNCA silence induced the upregulation of Bcl-2 and the downregulation of Bax, and the expression of NGF, BDNF and NT3 was substantially upregulated in cortical neurons...
  36. Qiu Y, Mao S, Qian B, Jiang J, Qiu X, Zhao Q, et al. A promoter polymorphism of neurotrophin 3 gene is associated with curve severity and bracing effectiveness in adolescent idiopathic scoliosis. Spine (Phila Pa 1976). 2012;37:127-33 pubmed publisher
    A genetic association study to comprehensively investigate variations of neurotrophin 3 (NTF3) gene polymorphisms in a Chinese Han population...
  37. Yao Q, Song R, Ao L, Cleveland J, Fullerton D, Meng X. Neurotrophin 3 upregulates proliferation and collagen production in human aortic valve interstitial cells: a potential role in aortic valve sclerosis. Am J Physiol Cell Physiol. 2017;312:C697-C706 pubmed publisher
    ..Recently, we observed that diseased human aortic valves overexpress growth factor neurotrophin 3 (NT3). In the present study, we tested the hypothesis that NT3 is a profibrogenic factor to human AVICs...
  38. Gruber Olipitz M, Strobel T, Chen W, Grotzer M, Quehenberger F, Slavc I, et al. Synthesis, chaperoning, and metabolism of proteins are regulated by NT-3/TrkC signaling in the medulloblastoma cell line DAOY. J Proteome Res. 2008;7:1932-44 pubmed publisher
    ..Protein levels of translational, splicing, processing, chaperone, protein handling, and metabolism machineries were shown to depend on neurotrophin-3-induced TrkC activation probably representing pharmacological targets. ..
  39. Lise M, Sparsa A, Marie I, Lalloue F, Ly K, Martel C, et al. Serum neurotrophin profile in systemic sclerosis. PLoS ONE. 2010;5:e13918 pubmed publisher
    ..The aims of this study are to determine blood levels of Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT-3) in SSc and to correlate them with clinical and biological data...
  40. Fabbri C, Serretti A. Genetics of long-term treatment outcome in bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2016;65:17-24 pubmed publisher
    ..Further studies focused on the outlined genes may be helpful to provide validated markers of BD treatment outcome. ..
  41. Donovan M, Hahn R, Tessarollo L, Hempstead B. Identification of an essential nonneuronal function of neurotrophin 3 in mammalian cardiac development. Nat Genet. 1996;14:210-3 pubmed
    b>Neurotrophin 3 (Nt3) is one of five neurotrophin growth factors which shape the development of the nervous system by regulating neuronal survival and differentiation...
  42. Martinez Moreno C, Fleming T, Carranza M, Avila Mendoza J, Luna M, Harvey S, et al. Growth hormone protects against kainate excitotoxicity and induces BDNF and NT3 expression in chicken neuroretinal cells. Exp Eye Res. 2018;166:1-12 pubmed publisher
    ..Intravitreal injections of GH restored brain derived neurotrophic factor (BDNF) expression in retinas treated with KA...
  43. Ernfors P, Lee K, Kucera J, Jaenisch R. Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell. 1994;77:503-12 pubmed
    ..Importantly, the number of muscle spindles in heterozygous mutant mice was half of that in control mice, indicating that NT-3 is present at limiting concentrations in the embryo. ..
  44. Godinho M, Teh L, Pollett M, Goodman D, Hodgetts S, Sweetman I, et al. Immunohistochemical, ultrastructural and functional analysis of axonal regeneration through peripheral nerve grafts containing Schwann cells expressing BDNF, CNTF or NT3. PLoS ONE. 2013;8:e69987 pubmed publisher
    ..from acellular nerve sheaths repopulated ex vivo with Schwann cells (SCs) modified to express brain-derived neurotrophic factor (BDNF), a secretable form of ciliary neurotrophic factor (CNTF), or neurotrophin-3 (NT3)...
  45. Guo Y, Su Z, Chen Y, Chai Z. Brain-derived neurotrophic factor/neurotrophin 3 regulate axon initial segment location and affect neuronal excitability in cultured hippocampal neurons. J Neurochem. 2017;142:260-271 pubmed publisher
    ..in the location of the AIS was associated with cellular secretory substances, including brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3)...
  46. Faniku C, O Shaughnessy E, Lorraine C, Johnstone S, Graham A, Greenhough S, et al. The Connexin Mimetic Peptide Gap27 and Cx43-Knockdown Reveal Differential Roles for Connexin43 in Wound Closure Events in Skin Model Systems. Int J Mol Sci. 2018;19: pubmed publisher
    ..Connexin43-SiRNA enhanced scrape wound closure in all the cell types under investigation. In HDNF and ADF, Connexin43-SiRNA enhanced cell proliferation rates, with enhanced proliferation also observed following ..
  47. Hattori M, Nanko S. Association of neurotrophin-3 gene variant with severe forms of schizophrenia. Biochem Biophys Res Commun. 1995;209:513-8 pubmed
    ..Individuals homozygous or heterozygous for the allele Glu-63 had a 2.595-fold increased risk of severe forms of schizophrenia. ..
  48. Barcena de Arellano M, Wagner M, Oldeweme J, Arnold J, Ebert A, Schneider A, et al. Neurotrophin expression is not affected in uteri of women with adenomyosis. J Mol Neurosci. 2012;47:495-504 pubmed publisher
    ..order to investigate neurotrophic properties in adenomyosis, the antibodies against nerve growth factor (NGF), neurotrophin 3 (NT-3), the high-affinity NGF receptor (TrkA), the low-affinity neurotrophin receptor (p75(NTR)), the neuronal ..
  49. Zhang X, Chen K, Song C, Song C. Inhibition of long non-coding RNA IGF2AS has profound effect on inducing neuronal growth and protecting local-anesthetic induced neurotoxicity in dorsal root ganglion neurons. Biomed Pharmacother. 2016;82:298-303 pubmed publisher
    ..SiRNA-mediated IGF2AS inhibition promoted neuronal growth, and induced IGF2, BDNF and NT3 upregulations at both gene and protein expressions...
  50. Auer T, Xiao T, Bercier V, Gebhardt C, Duroure K, Concordet J, et al. Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3. elife. 2015;4: pubmed publisher
    ..Thus, our study has uncovered an activity-dependent, retrograde signaling pathway that homeostatically controls axonal branching. ..
  51. Santos D, Gonzalez Perez F, Giudetti G, Micera S, Udina E, del Valle J, et al. Preferential Enhancement of Sensory and Motor Axon Regeneration by Combining Extracellular Matrix Components with Neurotrophic Factors. Int J Mol Sci. 2016;18: pubmed publisher
    ..laminin and nerve growth factor (NGF)/neurotrophin-3 (NT3) or collagen, fibronectin and brain-derived neurotrophic factor (BDNF) selectively enhanced sensory neurite outgrowth of DRG neurons and motor neurite outgrowth from ..
  52. Baydyuk M, Xie Y, Tessarollo L, Xu B. Midbrain-derived neurotrophins support survival of immature striatal projection neurons. J Neurosci. 2013;33:3363-9 pubmed publisher
    ..Here we report that brain-derived neurotrophic factor and neurotrophin-3 are anterogradely transported from midbrain dopaminergic neurons and support the ..
  53. Romero F, Marina M, Pieckenstain F. Novel components of leaf bacterial communities of field-grown tomato plants and their potential for plant growth promotion and biocontrol of tomato diseases. Res Microbiol. 2016;167:222-33 pubmed publisher
    ..Pseudomonas veronii (isolates BT4 and NT2), Pseudomonas rhodesiae (isolate BT2) and Pseudomonas cichorii (isolate NT3). After seed inoculation, BT2, BT4, MT3, MT8, NT2 and NT6 were re-isolated from leaf extracts...
  54. Ma Y, Hao L, Ke H, Liang Z, Ma J, Liu Z, et al. LuxS/AI-2 in Streptococcus agalactiae reveals a key role in acid tolerance and virulence. Res Vet Sci. 2017;115:501-507 pubmed publisher
    ..These findings suggest that luxS may be involved in the interruption of bacterial virulence and resistance to environmental factors. ..
  55. Wang J, Gao Y, Chen S, Duanmu C, Zhang J, Feng X, et al. The Effect of Repeated Electroacupuncture Analgesia on Neurotrophic and Cytokine Factors in Neuropathic Pain Rats. Evid Based Complement Alternat Med. 2016;2016:8403064 pubmed
    ..TNF-? mRNA, and IL-1 mRNA were detected by quantitative real-time PCR, and the proteins of BDNF, NGF, and NT3/4 were detected by Western blot...
  56. Liao M, Peng Z, Yang Z, Wei S, Martinek P. Identification of differentially expressed genes in a pistillody common wheat mutant using an annealing control primer system. Genet Mol Res. 2015;14:3995-4004 pubmed publisher
    ..b>NGF2 was identified in the double ridge to floret differentiation stages; HDB2 and HCG4 were identified in the stage of ..
  57. Zhang M, Zhang X, Kang J, Zhang H, Chen X, Liu N, et al. Matrine promotes NT3 expression in CNS cells in experimental autoimmune encephalomyelitis. Neurosci Lett. 2017;649:100-106 pubmed publisher
    Neurotrophin 3 (NT3) is a potent neurotrophic factor for promoting remyelination and recovery of neuronal function; upregulation of its expression in the central nervous system (CNS) is thus of major therapeutic importance for ..
  58. Kolar M, Itte V, Kingham P, Novikov L, Wiberg M, Kelk P. The neurotrophic effects of different human dental mesenchymal stem cells. Sci Rep. 2017;7:12605 pubmed publisher
    ..Application of neutralizing antibodies showed that brain derived neurotrophic factor plays an important mechanistic role by which the D-MSCs stimulate neurite outgrowth...
  59. Suenaga M, Ohmae H, Tsuji S, Itoh T, Nishimura O. Renaturation of recombinant human neurotrophin-3 from inclusion bodies using a suppressor agent of aggregation. Biotechnol Appl Biochem. 1998;28 ( Pt 2):119-24 pubmed
    ..Consequently, about 10 mg of purified neurotrophin-3 was prepared from 1 litre of culture broth. ..
  60. Bouzas Rodriguez J, Cabrera J, Delloye Bourgeois C, Ichim G, Delcros J, Raquin M, et al. Neurotrophin-3 production promotes human neuroblastoma cell survival by inhibiting TrkC-induced apoptosis. J Clin Invest. 2010;120:850-8 pubmed publisher
    ..Thus, we believe that our data suggest that NT-3/TrkC disruption is a putative alternative targeted therapeutic strategy for the treatment of NB. ..
  61. Yao Q, Song R, Ao L, Zhan Q, Cleveland J, Yu X, et al. Over-expression of neurotrophin 3 in human aortic valves affected by calcific disease induces the osteogenic responses via the Trk-Akt pathway. Biochim Biophys Acta. 2015;1852:1940-9 pubmed publisher
    ..Among these genes, mRNA levels of neurotrophin 3 (NT3) increased by 2 fold...
  62. Oron G, Ao A, Friedman O, Fisch B, Zhang X, Ben Haroush A, et al. Expression of neurotrophin 3 and its tropomyosin-related kinase receptor C in human preantral follicles. Fertil Steril. 2011;95:2056-62 pubmed publisher
    To investigate the expression of neurotrophin 3 (NT3) and its receptor tropomyosin-related kinase C (TrkC) in human preantral follicles. Neurotrophins appear to play important roles in preantral follicles...
  63. Hassanzadeh K, Nikzaban M, Moloudi M, Izadpanah E. Effect of selegiline on neural stem cells differentiation: a possible role for neurotrophic factors. Iran J Basic Med Sci. 2015;18:549-54 pubmed
    ..this study aimed to investigate the effects of selegiline on NSCs differentiation with focus on the role of neurotrophic factor gene expression. The NSCs were isolated from lateral ventricle of C57 mice brain...
  64. Allard J, Perez E, Fukui K, Carpenter P, Ingram D, De Cabo R. Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice. Behav Brain Res. 2016;301:1-9 pubmed publisher
  65. Bronzetti E, Artico M, Pompili E, Felici L, Stringaro A, Bosco S, et al. Neurotrophins and neurotransmitters in human palatine tonsils: an immunohistochemical and RT-PCR analysis. Int J Mol Med. 2006;18:49-58 pubmed
  66. Selim A, Selim S, Shalaby S, Mosaad H, Saber T. Neuroprotective effects of placenta-derived mesenchymal stromal cells in a rat model of experimental autoimmune encephalomyelitis. Cytotherapy. 2016;18:1100-13 pubmed publisher
    ..Moreover, there was an engraftment of the PDMSCs into the brain tissue. Human brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and neurotrophin 3 (NTF3) were significantly expressed in brains of rats ..
  67. Antunes Lopes T, Coelho A, Pinto R, Barros S, Cruz C, Cruz F, et al. Urinary Neurotrophin Levels Increase in Women With Stress Urinary Incontinence After a Midurethral Sling Procedure. Urology. 2017;99:49-56 pubmed publisher
    ..baseline and 1-year follow-up, urine was collected to measure nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) concentration, and Qmax variation was calculated...
  68. Arinami T, Takekoshi K, Itokawa M, Hamaguchi H, Toru M. Failure to find associations of the CA repeat polymorphism in the first intron and the Gly-63/Glu-63 polymorphism of the neurotrophin-3 gene with schizophrenia. Psychiatr Genet. 1996;6:13-5 pubmed
    ..We found similar allele and genotype frequencies of both polymorphisms between the schizophrenic and control groups. We failed to support associations between the polymorphisms of the neurotrophin-3 gene analyzed and schizophrenia. ..
  69. Zhang Y, Zhang W, Lin C, Ding Y, Huang S, Wu J, et al. Neurotrophin-3 gene modified mesenchymal stem cells promote remyelination and functional recovery in the demyelinated spinal cord of rats. J Neurol Sci. 2012;313:64-74 pubmed publisher
    ..Our study suggested that genetically modified MSCs could be a potential therapeutic avenue for improving the efficacy of stem cell treatment for neurodegenerative diseases such as MS. ..
  70. Huang L, Xian Q, Shen N, Shi L, Qu Y, Zhou L. Congenital absence of corticospinal tract does not severely affect plastic changes of the developing postnatal spinal cord. Neuroscience. 2015;301:338-50 pubmed publisher
    ..Contrary to control samples, in which ciliary neurotrophic factor (CNTF) protein levels increased from P0 to P7 and gradually decreased after P14, CNTF concentrations were ..
  71. Hodyl N, Crawford T, McKerracher L, Lawrence A, Pitcher J, Stark M. Antenatal steroid exposure in the late preterm period is associated with reduced cord blood neurotrophin-3. Early Hum Dev. 2016;101:57-62 pubmed publisher
    ..Cord blood neurotrophin-3 (NT-3), NT-4, nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) concentrations measured by ELISA...
  72. Ozcelik T, Rosenthal A, Francke U. Chromosomal mapping of brain-derived neurotrophic factor and neurotrophin-3 genes in man and mouse. Genomics. 1991;10:569-75 pubmed
    Brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NTF3) are two new members of the nerve growth factor gene family, which play important roles in the development and maintenance of the vertebrate nervous system...
  73. Lin C, Wang C, Hsu S, Liao L, Lin T, Hsueh C. Molecular Mechanisms Responsible for Neuron-Derived Conditioned Medium (NCM)-Mediated Protection of Ischemic Brain. PLoS ONE. 2016;11:e0146692 pubmed publisher
    ..Brain injection with TGFβ1, NT3, GDNF and ERK agonist (DADS) alone or in combination, therefore also significantly decreased the infarct volume of ..
  74. Pan Y, Zhang J, Liu W, Shu P, Yin B, Yuan J, et al. Dok5 is involved in the signaling pathway of neurotrophin-3 against TrkC-induced apoptosis. Neurosci Lett. 2013;553:46-51 pubmed publisher
    ..Taken together, we concluded that Dok5 is necessary for NT-3 signaling to block TrkC-induced apoptosis. ..
  75. Urfer R, Tsoulfas P, O Connell L, Hongo J, Zhao W, Presta L. High resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second immunoglobulin-like domain of the Trk receptors. J Biol Chem. 1998;273:5829-40 pubmed
    ..When selected TrkC and TrkA mutants with reduced binding were expressed on NIH3T3 cells, neurotrophin-induced autophosphorylation was strongly reduced or absent. ..
  76. Malamitsi Puchner A, Economou E, Boutsikou T, Nikolaou K, Vrachnis N. Neurotrophin-3 and FLT3 tyrosine kinase receptor in perinatal life. Mediators Inflamm. 2005;2005:53-6 pubmed
    ..03, respectively). Maternal and umbilical NT3 levels positively correlated with respective FLT3 levels (P = .003 and P = .03)...
  77. Wysokiński A. Serum levels of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in depressed patients with schizophrenia. Nord J Psychiatry. 2016;70:267-71 pubmed publisher
    Brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are neurotrophins-proteins that induce the survival, development, and function of neurons...
  78. Jones K, Reichardt L. Molecular cloning of a human gene that is a member of the nerve growth factor family. Proc Natl Acad Sci U S A. 1990;87:8060-4 pubmed
    ..Two neurotrophic factors, nerve growth factor and brain-derived neurotrophic factor, share substantial amino acid sequence identity...
  79. Ivanov S, Panaccione A, Brown B, Guo Y, Moskaluk C, Wick M, et al. TrkC signaling is activated in adenoid cystic carcinoma and requires NT-3 to stimulate invasive behavior. Oncogene. 2013;32:3698-710 pubmed publisher
    ..In summary, we describe in ACC a previously unrecognized pro-survival neurotrophin signaling pathway and link it with cancer progression. ..
  80. Jawhari S, Bessette B, Hombourger S, Durand K, Lacroix A, Labrousse F, et al. Autophagy and TrkC/NT-3 signaling joined forces boost the hypoxic glioblastoma cell survival. Carcinogenesis. 2017;38:592-603 pubmed publisher
    ..These data suggest that a combined treatment targeting these two pathways could be considered in order to induce the death of GBM cells. ..
  81. Prasad A, Teh D, Blasiak A, Chai C, Wu Y, Gharibani P, et al. Static Magnetic Field Stimulation Enhances Oligodendrocyte Differentiation and Secretion of Neurotrophic Factors. Sci Rep. 2017;7:6743 pubmed publisher
    ..2 and CaV1.3. Our findings emphasize the ability of glial cells such as OPCs to positively respond to moderate intensity SMF stimulation by exhibiting enhanced differentiation, functionality as well as neurotrophic factor release.
  82. Barh D, García Solano M, Tiwari S, Bhattacharya A, Jain N, Torres Moreno D, et al. BARHL1 Is Downregulated in Alzheimer's Disease and May Regulate Cognitive Functions through ESR1 and Multiple Pathways. Genes (Basel). 2017;8: pubmed publisher
    ..Estrogen Receptor 1 (ESR1) may constitute a network that regulates Neurotrophin 3 (NTF3)- and Brain Derived Neurotrophic Factor (BDNF)-mediated neurogenesis and neural survival; (ii) this is probably linked to AD pathways affecting ..
  83. Ray C, Hume K. Neck afferents and muscle sympathetic activity in humans: implications for the vestibulosympathetic reflex. J Appl Physiol (1985). 1998;84:450-3 pubmed
    We have shown previously that head-down neck flexion (HDNF) in humans elicits increases in muscle sympathetic nerve activity (MSNA). The purpose of this study was to determine the effect of neck muscle afferents on MSNA...
  84. Gratacos M, Escaramis G, Bustamante M, Saus E, Aguera Z, Bayés M, et al. Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease. J Psychiatr Res. 2010;44:834-40 pubmed publisher
  85. Fan J, Xiao Z, Zhang H, Chen B, Tang G, Hou X, et al. Linear ordered collagen scaffolds loaded with collagen-binding neurotrophin-3 promote axonal regeneration and partial functional recovery after complete spinal cord transection. J Neurotrauma. 2010;27:1671-83 pubmed publisher
    Neurotrophin-3 (NT3) is an important neurotrophic factor for spinal cord injury (SCI) repair. However, constant exchange of cerebrospinal fluid often decreases the effective dosage of NT3 at the targeted injury site...
  86. Hochhaus F, Koehne P, Schaper C, Butenandt O, Felderhoff Mueser U, Ring Mrozik E, et al. Elevated nerve growth factor and neurotrophin-3 levels in cerebrospinal fluid of children with hydrocephalus. BMC Pediatr. 2001;1:2 pubmed
    ..007). NGF and NT-3 concentrations are increased in children with hydrocephalus. This may represent an adaptive response of the brain to elevated ICP. ..
  87. Nosrat I, Seiger A, Olson L, Nosrat C. Expression patterns of neurotrophic factor mRNAs in developing human teeth. Cell Tissue Res. 2002;310:177-87 pubmed
    ..in rodents could be related to humans, we have now studied nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), glial cell-line derived neurotrophic factor (GDNF), ..
  88. Ramu J, Bockhorst K, Grill R, Mogatadakala K, Narayana P. Cortical reorganization in NT3-treated experimental spinal cord injury: Functional magnetic resonance imaging. Exp Neurol. 2007;204:58-65 pubmed
    ..resonance imaging (fMRI) studies were performed for visualizing ongoing brain plasticity in Neurotrophin-3 (NT3)-treated experimental spinal cord injury (SCI)...
  89. Mercader J, Saus E, Aguera Z, Bayés M, Boni C, Carreras A, et al. Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders. Hum Mol Genet. 2008;17:1234-44 pubmed publisher
    ..The reported data, in addition to the previous reported findings for BDNF and NTRK2, point neurotrophin signaling genes as key regulators of eating behavior and their altered cross-regulation as susceptibility factors for EDs. ..
  90. Hossain W, D Sa C, Morest D. Interactive roles of fibroblast growth factor 2 and neurotrophin 3 in the sequence of migration, process outgrowth, and axonal differentiation of mouse cochlear ganglion cells. J Neurosci Res. 2008;86:2376-91 pubmed publisher
    ..We used immunohistochemistry to locate neurotrophin 3 (NT3) and its high-affinity receptor (TrkC) in the auditory system, along with FGF2 and its R1 receptor, at ..
  91. Su Y, Zhou X, Foster B, Grills B, Xu J, Xian C. Roles of neurotrophins in skeletal tissue formation and healing. J Cell Physiol. 2017;: pubmed publisher
    ..Further studies, however, are needed to investigate if different neurotrophins have differential roles in skeletal repair, and if NT-3 can be a potential target of intervention for promoting bone fracture healing. ..
  92. Sajdel Sulkowska E, Xu M, Koibuchi N. Increase in cerebellar neurotrophin-3 and oxidative stress markers in autism. Cerebellum. 2009;8:366-72 pubmed publisher