neuropeptide Y


Gene Symbol: neuropeptide Y
Description: neuropeptide Y
Alias: PYY4, pro-neuropeptide Y, prepro-neuropeptide Y
Species: human
Products:     neuropeptide Y

Top Publications

  1. Kempna P, Korner M, Waser B, Hofer G, Nuoffer J, Reubi J, et al. Neuropeptide Y modulates steroid production of human adrenal H295R cells through Y1 receptors. Mol Cell Endocrinol. 2010;314:101-9 pubmed publisher
    b>Neuropeptide Y (NPY) is abundantly expressed in the nervous system and acts on target cells through NPY receptors. The human adrenal cortex and adrenal tumors express NPY receptor subtype Y1, but its function is unknown...
  2. Ding B, Bertilsson L, Wahlestedt C. The single nucleotide polymorphism T1128C in the signal peptide of neuropeptide Y (NPY) was not identified in a Korean population. J Clin Pharm Ther. 2002;27:211-2 pubmed
    ..SNP) T1128C, which causes an amino acid change from leucine(7) to proline(7) in the signal peptide of neuropeptide Y (NPY), has been found to be associated with multiple clinical parameters or disease...
  3. Itokawa M, Arai M, Kato S, Ogata Y, Furukawa A, Haga S, et al. Association between a novel polymorphism in the promoter region of the neuropeptide Y gene and schizophrenia in humans. Neurosci Lett. 2003;347:202-4 pubmed
    Hypoactivity of neuropeptide Y (NPY) is thought to be involved in the pathophysiology of schizophrenia, because post-mortem brain studies revealed a decrease of the NPY in schizophrenia, and antipsychotic treatments increase the NPY in ..
  4. Wai S, Kindler P, Lam E, Zhang A, Yew D. Distribution of neuropeptide Y-immunoreactive neurons in the human brainstem, cerebellum, and cortex during development. Cell Mol Neurobiol. 2004;24:667-84 pubmed
    1. Neuropeptide Y is found throughout the central nervous system where it appears to play a wide range of often poorly understood functions...
  5. Jia C, Liu Z, Liu T, Ning Y. The T1128C polymorphism of neuropeptide Y gene in a chinese population. Arch Med Res. 2005;36:175-7 pubmed
    Several papers have shown that the T1128C polymorphism of the neuropeptide Y (NPY) gene was related to certain diseases and disorders...
  6. Ruscica M, Dozio E, Boghossian S, Bovo G, Martos Riaño V, Motta M, et al. Activation of the Y1 receptor by neuropeptide Y regulates the growth of prostate cancer cells. Endocrinology. 2006;147:1466-73 pubmed
    This study deals with the role of neuropeptide Y (NPY) in the regulation of cell proliferation. NPY is expressed in the normal and tumoral prostate, but no data on its possible role in prostate cancer (PCa) progression are available...
  7. Zhou Z, Zhu G, Hariri A, ENOCH M, Scott D, Sinha R, et al. Genetic variation in human NPY expression affects stress response and emotion. Nature. 2008;452:997-1001 pubmed publisher
    ..b>Neuropeptide Y (NPY) is anxiolytic and its release is induced by stress...
  8. Rosmaninho Salgado J, Araújo I, Alvaro A, Mendes A, Ferreira L, Grouzmann E, et al. Regulation of catecholamine release and tyrosine hydroxylase in human adrenal chromaffin cells by interleukin-1beta: role of neuropeptide Y and nitric oxide. J Neurochem. 2009;109:911-22 pubmed publisher
    ..The effect of IL-1beta on neuropeptide Y (NPY) release and the intracellular pathways involved in catecholamine release evoked by IL-1beta and NPY were ..
  9. Sedláčková D, Kopečková J, Papezova H, Vybiral S, Kvasnickova H, Hill M, et al. Changes of plasma obestatin, ghrelin and NPY in anorexia and bulimia nervosa patients before and after a high-carbohydrate breakfast. Physiol Res. 2011;60:165-73 pubmed
    Peptides ghrelin, obestatin and neuropeptide Y (NPY) play an important role in regulation of energy homeostasis, the imbalance of which is associated with eating disorders anorexia (AN) and bulimia nervosa (BN)...

More Information

Publications112 found, 100 shown here

  1. Witt S, Buchmann A, Blomeyer D, Nieratschker V, Treutlein J, Esser G, et al. An interaction between a neuropeptide Y gene polymorphism and early adversity modulates endocrine stress responses. Psychoneuroendocrinology. 2011;36:1010-20 pubmed publisher
    ..b>Neuropeptide Y (NPY) plays a role in stress regulation and genetic variation in NPY may influence stress responses...
  2. Kask A, Harro J, von Horsten S, Redrobe J, Dumont Y, Quirion R. The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y. Neurosci Biobehav Rev. 2002;26:259-83 pubmed
    ..We conclude that endogenous NPY has an important role in reducing anxiety and serves as a physiological stabilizer of neural activity in circuits involved in the regulation of arousal and anxiety. ..
  3. Wallerstedt S, Skrtic S, Eriksson A, Ohlsson C, Hedner T. Association analysis of the polymorphism T1128C in the signal peptide of neuropeptide Y in a Swedish hypertensive population. J Hypertens. 2004;22:1277-81 pubmed
    The neuropeptide Y (NPY) signal peptide polymorphism T1128C has been linked to several risk factors for cardiovascular disease...
  4. Ma J, Nordman S, Möllsten A, Falhammar H, Brismar K, Dahlquist G, et al. Distribution of neuropeptide Y Leu7Pro polymorphism in patients with type 1 diabetes and diabetic nephropathy among Swedish and American populations. Eur J Endocrinol. 2007;157:641-5 pubmed
    The distribution of Leu7Pro polymorphism in the neuropeptide Y gene shows a geographical north to south gradient of decreasing frequency, suggesting that it may be a population-specific causal variant...
  5. Pons J, Kitlinska J, Jacques D, Perreault C, Nader M, Everhart L, et al. Interactions of multiple signaling pathways in neuropeptide Y-mediated bimodal vascular smooth muscle cell growth. Can J Physiol Pharmacol. 2008;86:438-48 pubmed publisher
    b>Neuropeptide Y (NPY), a sympathetic cotransmitter, acts via G protein-coupled receptors to stimulate constriction and vascular smooth muscle cell (VSMC) proliferation through interactions with its Y1 receptors...
  6. Domschke K, Dannlowski U, Hohoff C, Ohrmann P, Bauer J, Kugel H, et al. Neuropeptide Y (NPY) gene: Impact on emotional processing and treatment response in anxious depression. Eur Neuropsychopharmacol. 2010;20:301-9 pubmed publisher
    b>Neuropeptide Y (NPY) has been found to play a role in the pathomechanism of both anxiety and depression. Thus, NPY is a promising candidate in the investigation of the clinical phenotype of "anxious depression"...
  7. Hallden G, Hadi M, Hong H, Aponte G. Y receptor-mediated induction of CD63 transcripts, a tetraspanin determined to be necessary for differentiation of the intestinal epithelial cell line, hBRIE 380i cells. J Biol Chem. 1999;274:27914-24 pubmed
    Peptide YY (PYY) and neuropeptide Y (NPY) are peptides that coordinate intestinal activities in response to luminal and neuronal signals...
  8. Karvonen M, Valkonen V, Lakka T, Salonen R, Koulu M, Pesonen U, et al. Leucine7 to proline7 polymorphism in the preproneuropeptide Y is associated with the progression of carotid atherosclerosis, blood pressure and serum lipids in Finnish men. Atherosclerosis. 2001;159:145-51 pubmed
    ..This study provides important evidence suggesting that the Pro7 substitution in the prepro-NPY is an important risk factor for accelerated atherosclerotic progression, increased blood pressure and increased serum cholesterol in humans. ..
  9. Kitlinska J, Lee E, Movafagh S, Pons J, Zukowska Z. Neuropeptide Y-induced angiogenesis in aging. Peptides. 2002;23:71-7 pubmed
    ..Thus, NPY-dependent angiogenesis is impaired with age, which is associated with a decreased expression of endothelial NPY receptors (Y2) and DPPIV. ..
  10. Pettersson Fernholm K, Karvonen M, Kallio J, Forsblom C, Koulu M, Pesonen U, et al. Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with proteinuria, coronary heart disease, and glycemic control in type 1 diabetic patients. Diabetes Care. 2004;27:503-9 pubmed
    b>Neuropeptide Y is a potent vasoconstrictor thought to enhance the development of atherosclerosis...
  11. El Karim I, Linden G, Orr D, Lundy F. Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites. J Neuroimmunol. 2008;200:11-6 pubmed publisher
    ..whether the neuropeptides substance P (SP), neurokinin A (NKA), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY) and vasoactive intestinal polypeptide (VIP), displayed antimicrobial activity against Streptococcus ..
  12. Sjöholm L, Melas P, Forsell Y, Lavebratt C. PreproNPY Pro7 protects against depression despite exposure to environmental risk factors. J Affect Disord. 2009;118:124-30 pubmed publisher extensive evidence, from both clinical cases and rodent models, for reduced levels of the widely expressed neuropeptide Y (NPY) in anxiety and depressive disorders...
  13. Sommer W, Lidström J, Sun H, Passer D, ESKAY R, Parker S, et al. Human NPY promoter variation rs16147:T>C as a moderator of prefrontal NPY gene expression and negative affect. Hum Mutat. 2010;31:E1594-608 pubmed publisher
    ..Our results show the importance of rs16147:T>C for regulation of NPY gene expression and brain function. ..
  14. Liu A, Furusato B, Ravindranath L, Chen Y, Srikantan V, McLeod D, et al. Quantitative analysis of a panel of gene expression in prostate cancer--with emphasis on NPY expression analysis. J Zhejiang Univ Sci B. 2007;8:853-9 pubmed publisher
    ..Studies along these lines have potential to define PCa-associated gene expression alterations and likely co-regulation of genes/pathways critical in the biology of PCa onset/progression. ..
  15. Lecat S, Belemnaba L, Galzi J, Bucher B. Neuropeptide Y receptor mediates activation of ERK1/2 via transactivation of the IGF receptor. Cell Signal. 2015;27:1297-304 pubmed publisher
    b>Neuropeptide Y binds to G-protein coupled receptors whose action results in inhibition of adenylyl cyclase activity...
  16. Kovacevic S, Nestorov J, Matić G, Elaković I. Chronic Stress Combined with a Fructose Diet Reduces Hypothalamic Insulin Signaling and Antioxidative Defense in Female Rats. Neuroendocrinology. 2018;: pubmed publisher
    ..responses and energy balance, insulin and glucocorticoids regulate the expression of orexigenic neuropeptides, neuropeptide Y (NPY) and agouti-related protein (AgRP), and anorexigenic neuropeptides, proopio-melanocortin (POMC) and ..
  17. Bigio B, Mathe A, Sousa V, Zelli D, Svenningsson P, McEwen B, et al. Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: Implications for treatment resistance. Proc Natl Acad Sci U S A. 2016;113:7906-11 pubmed publisher
    ..The approach here serves as a model for identifying markers and underlying mechanisms of predisposition to diseases and treatment responsiveness that may be useful in translation to human behavior and psychopathology. ..
  18. Dwyer D, Awatramani P, Thakur R, Seeni R, Aamodt E. Social feeding in Caenorhabditis elegans is modulated by antipsychotic drugs and calmodulin and may serve as a protophenotype for asociality. Neuropharmacology. 2015;92:56-62 pubmed publisher
    ..It is regulated by the highly conserved neuropeptide Y receptor, NPR-1, and we speculated that social feeding should be affected by antipsychotic drugs...
  19. Nguyen P, GREENE E, Ishola P, Huff G, Donoghue A, Bottje W, et al. Chronic Mild Cold Conditioning Modulates the Expression of Hypothalamic Neuropeptide and Intermediary Metabolic-Related Genes and Improves Growth Performances in Young Chicks. PLoS ONE. 2015;10:e0142319 pubmed publisher
    ..05). CMCC significantly decreased the expression of both the hypothalamic orexigenic neuropeptide Y (NPY) and anorexigenic cocaine and amphetamine regulated transcript (CART) in chick brain which may explain ..
  20. Calviño C, Império G, Wilieman M, Costa E Sousa R, Souza L, Trevenzoli I, et al. Hypothyroidism Induces Hypophagia Associated with Alterations in Protein Expression of Neuropeptide Y and Proopiomelanocortin in the Arcuate Nucleus, Independently of Hypothalamic Nuclei-Specific Changes in Leptin Signaling. Thyroid. 2016;26:134-43 pubmed publisher
    ..It was hypothesized that hypothyroidism modulates the expression of neuropeptides: orexigenic neuropeptide Y (NPY) and anorexigenic proopiomelanocortin (POMC), independently of inducing nuclei-specific changes in ..
  21. Tinkov A, Ajsuvakova O, Skalnaya M, Skalny A, Aschner M, Suliburska J, et al. Organotins in obesity and associated metabolic disturbances. J Inorg Biochem. 2018;191:49-59 pubmed publisher
    ..effects, organotin exposure may also affect neural circuits of appetite regulation, being characterized by neuropeptide Y (NPY) up-regulation in parallel with of pro-opiomelanocortin (POMC), Agouti-related protein (AgRP), and ..
  22. Gerard N, Robin E. Cellular and molecular mechanisms of the preovulatory follicle differenciation and ovulation: What do we know in the mare relative to other species. Theriogenology. 2019;130:163-176 pubmed publisher
    ..2) involvement of neuropeptides, such as kisspeptin, neurotrophins and neuronal growth factor, neuropeptide Y (NPY), 3) the modification of steroidogenesis, steroids intrafollicular levels and enzymes activity, 4) the ..
  23. Sand E, Roth B, Weström B, Bonn P, Ekblad E, Ohlsson B. Structural and functional consequences of buserelin-induced enteric neuropathy in rat. BMC Gastroenterol. 2014;14:209 pubmed publisher
    ..peptide (CGRP), cocaine- and amphetamine-related transcript (CART), galanin, gastrin-releasing peptide (GRP), neuropeptide Y (NPY), nitric oxide synthase (NOS), serotonin, substance P (SP), vasoactive intestinal peptide (VIP) or ..
  24. Dong P, Gu X, Zhu G, Li M, Ma B, Zi Y. Melatonin Induces Osteoblastic Differentiation of Mesenchymal Stem Cells and Promotes Fracture Healing in a Rat Model of Femoral Fracture via Neuropeptide Y/Neuropeptide Y Receptor Y1 Signaling. Pharmacology. 2018;102:272-280 pubmed publisher
    ..We found that MLT treatment upregulated the neuropeptide Y (NPY) and NPY receptor Y1 (NPY1R) expression, and promoted the proliferation and migration of MSCs, which was ..
  25. Xu K, Pan X, Qiu X, Wang D, Dong N, Yang L, et al. Neural crest-derived cells migrate from nerve to participate in Achilles tendon remodeling. Wound Repair Regen. 2018;26:54-63 pubmed publisher
    ..Importantly, the existing neuropeptide Y (NPY) and neuropeptide Y receptor (NPYr) in the invading nerve and blood vessels were directly correlated...
  26. Chong A, Vogt M, Hill A, Brüning J, Zeltser L. Central insulin signaling modulates hypothalamus-pituitary-adrenal axis responsiveness. Mol Metab. 2015;4:83-92 pubmed publisher
    ..Alterations in InsR signals in neurons that integrate metabolic and psychiatric information could contribute to the high co-morbidity of obesity and mental disorders. ..
  27. Liu J, Hakucho A, Liu X, Fujimiya T. Acute restraint stress provokes sudden cardiac death in normotensive rats and enhances susceptibility to arrhythmogenic effects of adrenaline in spontaneously hypertensive rats. Leg Med (Tokyo). 2016;21:19-28 pubmed publisher the increases in the ratio of low-frequency and high-frequency powers in HRV, the ratio of myocardial neuropeptide Y (NPY) and acetylcholinesterase (AChE) mRNA expressions, and the up-regulation of LV Cx43 mRNA expression; in ..
  28. Ha S, Baver S, Huo L, Gata A, Hairston J, Huntoon N, et al. Somato-dendritic localization and signaling by leptin receptors in hypothalamic POMC and AgRP neurons. PLoS ONE. 2013;8:e77622 pubmed publisher
    ..Hypothalamic pro-opiomelanocortin (POMC) and agouti-related peptide (AgRP)/Neuropeptide Y (NPY)/GABA neurons produce anorexigenic and orexigenic neuropeptides and neurotransmitters, and express the ..
  29. Roperch J, Incitti R, Forbin S, Bard F, Mansour H, Mesli F, et al. Aberrant methylation of NPY, PENK, and WIF1 as a promising marker for blood-based diagnosis of colorectal cancer. BMC Cancer. 2013;13:566 pubmed publisher
    ..This panel of markers, if validated, can also be a cost effective screening tool for the detection of asymptomatic cancer patients for colonoscopy. ..
  30. Dörr O, Ewen S, Liebetrau C, Möllmann H, Gaede L, Linz D, et al. Neuropeptide Y as an indicator of successful alterations in sympathetic nervous activity after renal sympathetic denervation. Clin Res Cardiol. 2015;104:1064-71 pubmed publisher
    ..b>Neuropeptide Y (NPY) is a neurotransmitter that is co-released with norepinephrine and is up-regulated during increased ..
  31. Horsnell H, Baldock P. Osteoblastic Actions of the Neuropeptide Y System to Regulate Bone and Energy Homeostasis. Curr Osteoporos Rep. 2016;14:26-31 pubmed publisher
    ..b>Neuropeptide Y is one such factor that co-regulates these two processes...
  32. Okubo T, Harada S. Polymorphism of the neuropeptide Y gene: an association study with alcohol withdrawal. Alcohol Clin Exp Res. 2001;25:59S-62S pubmed
    b>Neuropeptide Y (NPY) exists in both the central and peripheral nervous system and is thought to modulate many functions such as feeding behavior, anxiety-associated behavior, circadian rhythm, seizure modulation, and hormone secretion...
  33. Stephens D, Saad A, Bennett L, Kosiba W, Johnson J. Neuropeptide Y antagonism reduces reflex cutaneous vasoconstriction in humans. Am J Physiol Heart Circ Physiol. 2004;287:H1404-9 pubmed
    ..To test whether neuropeptide Y (NPY) has a role, in two series of experiments we slowly reduced whole body skin temperature (TSK) from 34...
  34. Tung Y, Ayuso E, Shan X, Bosch F, O Rahilly S, Coll A, et al. Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats. PLoS ONE. 2010;5:e8771 pubmed publisher
    ..Importantly, this provide the first indication that selective alteration of FTO levels in the hypothalamus can influence food intake, a finding consistent with the reported effects of FTO alleles on appetite and food intake in man. ..
  35. Wang G, Tachibana T, Gilbert E, Cline M. Exogenous prolactin-releasing peptide's orexigenic effect is associated with hypothalamic neuropeptide Y in chicks. Neuropeptides. 2015;54:79-83 pubmed publisher
    ..The mRNA abundance of several appetite-associated neuropeptide genes was quantified and hypothalamic neuropeptide Y (NPY) mRNA was increased in PrRP-injected chicks...
  36. Li X, Wu Y, Jiang P, Wang X, you S, Zheng L, et al. [Establishment and characterization of a minipig model of microvascular coronary artery spasm]. Zhonghua Xin Xue Guan Bing Za Zhi. 2015;43:811-5 pubmed
    ..the feasibility of establishing a porcine model of microvascular coronary artery spasm by intracoronary neuropeptide Y (NPY) infusion, and to analyze the characterization of this model...
  37. Palus K, Chrobok L, Kepczynski M, Lewandowski M. Enkephalin and neuropeptide-Y interaction in the intergeniculate leaflet network, a part of the mammalian biological clock. Neuroscience. 2017;343:10-20 pubmed publisher
    ..In rat, two main GABAergic subpopulations can be distinguished in the IGL: neurons synthesizing neuropeptide Y (NPY), which directly innervates the suprachiasmatic nuclei, and enkephalinergic cells, which connect ..
  38. Wang H, Duan S, Xing Q, Du J, Li X, Xu Y, et al. [Association study between NPY and YWHAH gene polymorphisms and schizophrenia]. Yi Chuan Xue Bao. 2005;32:1235-40 pubmed
    ..05). The results suggest that the polymorphisms - 485C > T (NPY) and G753A (YWHAH) are unlikely to be linked with genetic susceptibility to schizophrenia in the Chinese Han population. ..
  39. Karvonen M, Ruottinen S, Koulu M, Pesonen U, Niinikoski H, Rask Nissilä L, et al. Nutrient intake, weight, and Leu7Pro polymorphism in prepro-neuropeptide Y in children. J Clin Endocrinol Metab. 2006;91:4664-8 pubmed
    The important role of neuropeptide Y (NPY) in the regulation of food intake and energy balance has been firmly documented in rodents, but human data are sparse...
  40. Kohno D, Yada T. Arcuate NPY neurons sense and integrate peripheral metabolic signals to control feeding. Neuropeptides. 2012;46:315-9 pubmed publisher
    ..These findings suggest that NPY neuron in the arcuate nucleus is an essential feeding center to induce food intake in response to peripheral metabolic state. ..
  41. Laddha N, Dwivedi M, Mansuri M, Singh M, Patel H, Agarwal N, et al. Association of neuropeptide Y (NPY), interleukin-1B (IL1B) genetic variants and correlation of IL1B transcript levels with vitiligo susceptibility. PLoS ONE. 2014;9:e107020 pubmed publisher
    ..Up-regulation of IL1B transcript in patients advocates its possible role in autoimmune pathogenesis of vitiligo. ..
  42. Sahu M, Anamthathmakula P, Sahu A. Hypothalamic Phosphodiesterase 3B Pathway Mediates Anorectic and Body Weight-Reducing Effects of Insulin in Male Mice. Neuroendocrinology. 2017;104:145-156 pubmed
    ..we examined the effect of cilostamide on insulin-induced proopiomelanocortin (Pomc), neurotensin (Nt), neuropeptide Y (Npy) and agouti-related peptide (Agrp) gene expression in the hypothalamus by qPCR...
  43. MACKAY H, Charbonneau V, St Onge V, Murray E, Watts A, Wellman M, et al. Rats with a truncated ghrelin receptor (GHSR) do not respond to ghrelin, and show reduced intake of palatable, high-calorie food. Physiol Behav. 2016;163:88-96 pubmed publisher
    ..Fasted FHH-GHSR(m1/Mcwi) rats exhibited increased Agouti-Related Peptide (AgRP) and Neuropeptide Y (NPY) expression in the Arcuate Nucleus (ARC), indicative of altered central regulation of feeding and energy ..
  44. Schmeltzer S, Herman J, Sah R. Neuropeptide Y (NPY) and posttraumatic stress disorder (PTSD): A translational update. Exp Neurol. 2016;284:196-210 pubmed publisher
    ..In this review, we discuss evidence supporting the relevance of neuropeptide Y (NPY), a stress regulatory transmitter in PTSD...
  45. Dimitri P, Rosen C. The Central Nervous System and Bone Metabolism: An Evolving Story. Calcif Tissue Int. 2017;100:476-485 pubmed publisher
    ..Other central regulators of bone metabolism have since been identified including neuropeptide Y (NPY), serotonin, endocannabinoids, cocaine- and amphetamine-regulated transcript (CART), adiponectin, ..
  46. Khan D, Vasu S, Moffett R, Irwin N, Flatt P. Influence of neuropeptide Y and pancreatic polypeptide on islet function and beta-cell survival. Biochim Biophys Acta Gen Subj. 2017;1861:749-758 pubmed publisher
    In the present study we assessed the impact of neuropeptide Y receptor (NPYR) modulators, neuropeptide Y (NPY) and pancreatic polypeptide (PP), on islet function and beta-cell survival...
  47. Lucas A, Richards D, Ramirez L, Lutterschmidt D. Arginine Vasotocin and Neuropeptide Y Vary with Seasonal Life-History Transitions in Garter Snakes. Integr Comp Biol. 2017;57:1166-1183 pubmed publisher
    ..mechanisms that regulate such behavioral transitions are poorly understood, arginine vasotocin (AVT) and neuropeptide Y (NPY) are excellent candidates because they modulate reproductive and feeding behavior, respectively...
  48. Mundinger T, Taborsky G. Differential action of hepatic sympathetic neuropeptides: metabolic action of galanin, vascular action of NPY. Am J Physiol Endocrinol Metab. 2000;278:E390-7 pubmed
    ..Because activation of canine hepatic nerves releases the neuropeptides galanin and neuropeptide Y (NPY) as well as the classical neurotransmitter norepinephrine (NE), we sought to determine the relative role ..
  49. Sjöholm L, Kovanen L, Saarikoski S, Schalling M, Lavebratt C, Partonen T. CLOCK is suggested to associate with comorbid alcohol use and depressive disorders. J Circadian Rhythms. 2010;8:1 pubmed publisher
    ..Together with previous reports it indicates that the CLOCK variations we found here may be a vulnerability factor to depression given the exposure to alcohol in individuals having AUD. ..
  50. Pałasz A, Bandyszewska M, Rojczyk E, Wiaderkiewicz R. Effect of extended olanzapine administration on POMC and neuropeptide Y mRNA levels in the male rat amygdala and hippocampus. Pharmacol Rep. 2016;68:292-6 pubmed publisher
    ..b>Neuropeptide Y (NPY) and proopiomelanocortin (POMC) functions are quite well studied, however little is known about their ..
  51. Conceição E, Carvalho J, Manhães A, Guarda D, Figueiredo M, Quitete F, et al. Effect of Early Overfeeding on Palatable Food Preference and Brain Dopaminergic Reward System at Adulthood: Role of Calcium Supplementation. J Neuroendocrinol. 2016;28: pubmed publisher
    ..They also had higher neuropeptide Y (NPY) and lower pro-opiomelanocortin contents in the ARC...
  52. Park M, Lee J, Kim N, Min W, Lee J, Kim K, et al. Neuropeptide Y Induces Hematopoietic Stem/Progenitor Cell Mobilization by Regulating Matrix Metalloproteinase-9 Activity Through Y1 Receptor in Osteoblasts. Stem Cells. 2016;34:2145-56 pubmed publisher
    ..In this study, we investigate the functional role of neuropeptide Y (NPY) on this process...
  53. Palus K, Całka J. Neurochemical Plasticity of the Coeliac-Superior Mesenteric Ganglion Complex Neurons Projecting to the Prepyloric Area of the Porcine Stomach following Hyperacidity. Neural Plast. 2016;2016:8596214 pubmed publisher
    ..FB-positive perikarya displayed immunoreactivity to tyrosine hydroxylase (TH), dopamine ?-hydroxylase (D?H), neuropeptide Y (NPY), and galanin (GAL)...
  54. Pham T, He J, Kakazu A, Jun B, Bazan N, Bazan H. Defining a mechanistic link between pigment epithelium-derived factor, docosahexaenoic acid, and corneal nerve regeneration. J Biol Chem. 2017;292:18486-18499 pubmed publisher
    ..Surprisingly, corneal injury and treatment with PEDF + DHA induced transcription of neuropeptide y (npy), small proline-rich protein 1a (sprr1a), and vasoactive intestinal peptide (vip) in ..
  55. Yu C, Hsieh Y, Chen P, Chen J, Kuo D. Knockdown of the transcript of extracellular signal-regulated kinase in the brain modulated hypothalamic neuropeptide-mediated appetite control in amphetamine-treated rats. Br J Pharmacol. 2017;: pubmed publisher
    ..of dopamine stored in synaptic terminals, which can suppress appetite by changing the expression levels of neuropeptide Y (NPY) and proopiomelanocortin (POMC) in the hypothalamus...
  56. Pesonen U. NPY L7P polymorphism and metabolic diseases. Regul Pept. 2008;149:51-5 pubmed publisher
    b>Neuropeptide Y (NPY) is an abundant and widespread peptide in mammalian nervous system, both in the central and peripheral nervous systems...
  57. Diaz F, Meary A, Arranz M, RUANO G, Windemuth A, de Leon J. Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels. Schizophr Res. 2009;115:136-40 pubmed publisher
    ..b>Neuropeptide Y (NPY) gene (rs1468271) and ACACB gene (rs2241220) SNPs were significantly associated with severe ..
  58. Jaakkola U, Kakko T, Seppala H, Vainio Jylhä E, Vahlberg T, Raitakari O, et al. The Leu7Pro polymorphism of the signal peptide of neuropeptide Y (NPY) gene is associated with increased levels of inflammatory markers preceding vascular complications in patients with type 2 diabetes. Microvasc Res. 2010;80:433-9 pubmed publisher
    The Leucine7 to Proline7 (Leu7Pro) polymorphism of the signal peptide of neuropeptide Y (NPY) increases risk for vascular complications in diabetes...
  59. Tilan J, Everhart L, Abe K, Kuo Bonde L, Chalothorn D, Kitlinska J, et al. Platelet neuropeptide Y is critical for ischemic revascularization in mice. FASEB J. 2013;27:2244-55 pubmed publisher
    We previously reported that the sympathetic neurotransmitter neuropeptide Y (NPY) is potently angiogenic, primarily through its Y2 receptor, and that endogenous NPY is crucial for capillary angiogenesis in rodent hindlimb ischemia...
  60. Dicken M, Hughes A, Hentges S. Gad1 mRNA as a reliable indicator of altered GABA release from orexigenic neurons in the hypothalamus. Eur J Neurosci. 2015;42:2644-53 pubmed publisher
    ..results show that the expression of Gad1 mRNA (encoding the GAD67 enzyme) was increased in hypothalamic neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons after an overnight fast, consistent with the ability of GABA from ..
  61. Helboe L, Egebjerg J, de Jong I. Distribution of serotonin receptor 5-HT6 mRNA in rat neuronal subpopulations: A double in situ hybridization study. Neuroscience. 2015;310:442-54 pubmed publisher
    ..These data provide new insights into the mechanisms of 5-HT6R signaling. ..
  62. Ledri L, Melin E, Christiansen S, Gøtzsche C, Cifra A, Woldbye D, et al. Translational approach for gene therapy in epilepsy: Model system and unilateral overexpression of neuropeptide Y and Y2 receptors. Neurobiol Dis. 2016;86:52-61 pubmed publisher
    ..model of chronic epilepsy in rats could be clinically relevant; and (ii) whether a translationally designed neuropeptide Y (NPY)/Y2 receptor-based gene therapy approach targeting only the seizure-generating focus unilaterally can ..
  63. Lu Y, Ho R. An association between neuropeptide Y levels and leukocyte subsets in stress-exacerbated asthmatic mice. Neuropeptides. 2016;57:53-8 pubmed publisher
    b>Neuropeptide Y (NPY) was recently proposed to be associated with stress and airway inflammation; however, this has rarely been studied in animal models of asthma...
  64. Hadad Ophir O, Ardi Z, Brande Eilat N, Kehat O, Anunu R, Richter Levin G. Exposure to prolonged controllable or uncontrollable stress affects GABAergic function in sub-regions of the hippocampus and the amygdala. Neurobiol Learn Mem. 2017;138:271-280 pubmed publisher
    ..task, focusing on the GABA-related factors glutamate decarboxylase (GAD)65, cholecystokinin (CCK) and neuropeptide Y (NPY)...
  65. de Luis D, Izaola O, De La Fuente B, Primo D, Aller R. Polymorphism of neuropeptide Y gene rs16147 modifies the response to a hypocaloric diet on cardiovascular risk biomarkers and adipokines. J Hum Nutr Diet. 2017;30:159-165 pubmed publisher
    ..1 (0.3) pg mL-1 ] (P = 0.01). We found that the rs164147 genotype affected the reduction of waist circumference, HOMA-IR, insulin, CRP and IL-6 levels in response to weight loss diet in obese subjects. ..
  66. FLETCHER M, Rosenthal M, Antoni M, Ironson G, Zeng X, Barnes Z, et al. Plasma neuropeptide Y: a biomarker for symptom severity in chronic fatigue syndrome. Behav Brain Funct. 2010;6:76 pubmed publisher
    ..Abnormalities in stress responses have been identified as potential triggers or mediators of CFS symptoms. This study focused on the stress mediator neuropeptide Y (NPY). We hypothesized that NPY would be a useful biomarker for CFS.
  67. Holzer P, Reichmann F, Farzi A. Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis. Neuropeptides. 2012;46:261-74 pubmed publisher
    ..The members of the neuropeptide Y (NPY) family of biologically active peptides, NPY, peptide YY (PYY) and pancreatic polypeptide (PP), are ..
  68. Garrigou S, Perkins G, Garlan F, Normand C, Didelot A, Le Corre D, et al. A Study of Hypermethylated Circulating Tumor DNA as a Universal Colorectal Cancer Biomarker. Clin Chem. 2016;62:1129-39 pubmed publisher
    ..Hypermethylation of WIF1 (WNT inhibitory factor 1) and NPY (neuropeptide Y) genes was significantly higher in tumor tissue compared to normal tissue, independently of tumor stage...
  69. Ladrón de Guevara Miranda D, Millón C, Rosell Valle C, Pérez Fernández M, Missiroli M, Serrano A, et al. Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis. Dis Model Mech. 2017;10:323-336 pubmed publisher
    ..Relevant hippocampal features [basal c-Fos activity, GABA+, parvalbumin (PV)+ and neuropeptide Y (NPY)+ interneurons and adult neurogenesis (cell proliferation and immature neurons)] were ..
  70. Wang R, Yan F, Liao R, Wan P, Little P, Zheng W. Role of brain-derived neurotrophic factor and nerve growth factor in the regulation of Neuropeptide W in vitro and in vivo. Mol Cell Endocrinol. 2017;447:71-78 pubmed publisher
  71. Borck P, Batista T, Vettorazzi J, Camargo R, Boschero A, Vieira E, et al. Protein malnutrition after weaning disrupts peripheral clock and daily insulin secretion in mice. J Nutr Biochem. 2017;50:54-65 pubmed publisher
  72. Kruse M, Suarez L, Coirini H. LXR activation increases the expression of GnRH AND αMSH in the rat hypothalamus in vivo. Neurosci Lett. 2018;664:20-27 pubmed publisher
  73. Sitticharoon C, Sukharomana M, Likitmaskul S, Churintaraphan M, Maikaew P. Corrigendum to: Increased high molecular weight adiponectin, but decreased total adiponectin and kisspeptin, in central precocious puberty compared with aged-matched prepubertal girls. Reprod Fertil Dev. 2017;29:2506 pubmed publisher was to compare serum leptin, kisspeptin, total adiponectin, high molecular weight (HMW) adiponectin and neuropeptide Y (NPY) levels between girls with central precocious puberty (CPP; n=26, 7-9...
  74. Han J, Zuo J, Zhu D, Gao C. The correlation between SNPs within the gene of adrenergic receptor and neuropeptide Y and risk of cervical vertigo. J Clin Lab Anal. 2017;: pubmed publisher
    ..The current investigation was aimed to explore the potential associations of SNPs within ADRB2, ADRB1, NPY, and ADRA1A with risk and prognosis of cervical vertigo...
  75. Karvonen M, Koulu M, Pesonen U, Uusitupa M, Tammi A, Viikari J, et al. Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with birth weight and serum triglyceride concentration in preschool aged children. J Clin Endocrinol Metab. 2000;85:1455-60 pubmed
    The Leu7Pro gene variant of the signal peptide part of neuropeptide Y (NPY), has been shown to affect cholesterol metabolism in obese adults...
  76. Okahisa Y, Ujike H, Kotaka T, Morita Y, Kodama M, Inada T, et al. Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence. Psychiatry Clin Neurosci. 2009;63:417-22 pubmed publisher
    b>Neuropeptide Y (NPY) is a 36-amino acid peptide that is widely distributed in the brain, adrenal medulla, and sympathetic nervous system...
  77. Bi S, Kim Y, Zheng F. Dorsomedial hypothalamic NPY and energy balance control. Neuropeptides. 2012;46:309-14 pubmed publisher
    b>Neuropeptide Y (NPY) is a potent hypothalamic orexigenic peptide. Within the hypothalamus, Npy is primarily expressed in the arcuate nucleus (ARC) and the dorsomedial hypothalamus (DMH)...
  78. Parizadeh S, Jamialahmadi K, Rooki H, Zaim Kohan H, Mirhafez S, Hosseini N, et al. Association of neuropeptide Y gene rs16147 polymorphism with metabolic syndrome in patients with documented coronary artery disease. Ann Hum Biol. 2015;42:178-83 pubmed publisher
    ..b>Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD)...
  79. Freitag Wolf S, Dommisch H, Graetz C, Jockel Schneider Y, Harks I, Staufenbiel I, et al. Genome-wide exploration identifies sex-specific genetic effects of alleles upstream NPY to increase the risk of severe periodontitis in men. J Clin Periodontol. 2014;41:1115-21 pubmed publisher
    ..85) upstream the gene neuropeptide Y (NPY) suggested gene-sex interaction (p < 5 × 10(-5) )...
  80. Zitnik G. Control of arousal through neuropeptide afferents of the locus coeruleus. Brain Res. 2016;1641:338-50 pubmed publisher
    ..factor (CRF), orexin (ORX), endogenous opioids, substance P (SP), melanin-concentrating hormone (MCH), neuropeptide Y (NPY) and somatostatin (SS)...
  81. He Y, Shu G, Yang Y, Xu P, Xia Y, Wang C, et al. A Small Potassium Current in AgRP/NPY Neurons Regulates Feeding Behavior and Energy Metabolism. Cell Rep. 2016;17:1807-1818 pubmed publisher
    Neurons that co-express agouti-related peptide (AgRP) and neuropeptide Y (NPY) are indispensable for normal feeding behavior...
  82. Ding X, Kou X, Zhang Y, Zhang X, Cheng G, Jia T. Leptin siRNA promotes ovarian granulosa cell apoptosis and affects steroidogenesis by increasing NPY2 receptor expression. Gene. 2017;633:28-34 pubmed publisher
    Leptin has been found to be involved in the ovarian granulosa cell apoptosis and steroidogenesis. Loss of neuropeptide Y (NPY) can correct the obesity syndrome of mutant mice lacking of leptin (ob/ob)...
  83. Koehnke M, Schick S, Lutz U, Willecke M, Koehnke A, Kolb W, et al. Severity of alcohol withdrawal symptoms and the T1128C polymorphism of the neuropeptide Y gene. J Neural Transm (Vienna). 2002;109:1423-9 pubmed
    b>Neuropeptide Y (NPY) modulates ethanol drinking in rodents. The C-allele of the T1128C polymorphism of the human NPY gene has been previously associated with elevated alcohol consumption in a Finn population study...
  84. Ding B, Kull B, Liu Z, Mottagui Tabar S, Thonberg H, Gu H, et al. Human neuropeptide Y signal peptide gain-of-function polymorphism is associated with increased body mass index: possible mode of function. Regul Pept. 2005;127:45-53 pubmed
    b>Neuropeptide Y (NPY) has been implicated in the control of food intake and energy balance based on many observations in animals...
  85. Olza J, Gil Campos M, Leis R, Rupérez A, Tojo R, Cañete R, et al. Influence of variants in the NPY gene on obesity and metabolic syndrome features in Spanish children. Peptides. 2013;45:22-7 pubmed publisher
    Variants in the neuropeptide Y (NPY) gene have been associated with obesity and its traits...
  86. Lagraauw H, Westra M, Bot M, Wezel A, Van Santbrink P, Pasterkamp G, et al. Vascular neuropeptide Y contributes to atherosclerotic plaque progression and perivascular mast cell activation. Atherosclerosis. 2014;235:196-203 pubmed publisher
    b>Neuropeptide Y is an abundantly expressed neurotransmitter capable of modulating both immune and metabolic responses related to the development of atherosclerosis...
  87. Parizadeh S, Jamialahmadi K, Rooki H, Mirhafez S, Moohebati M, Hosseini N, et al. Lack of an association between a functional polymorphism in the neuropeptide Y gene promoter and the presence of coronary artery disease in an Iranian population. Ann Nutr Metab. 2014;65:333-40 pubmed publisher
    ..Variants of the neuropeptide Y (NPY) gene, whose products play an important role in regulating several physiological functions, have been ..
  88. Patel R, Dwivedi M, Mansuri M, Ansarullah -, Laddha N, Thakker A, et al. Association of Neuropeptide-Y (NPY) and Interleukin-1beta (IL1B), Genotype-Phenotype Correlation and Plasma Lipids with Type-II Diabetes. PLoS ONE. 2016;11:e0164437 pubmed publisher
    b>Neuropeptide Y (NPY) is known to play a role in the regulation of satiety, energy balance, body weight, and insulin release. Interleukin-1beta (IL1B) has been associated with loss of beta-cell mass in type-II diabetes (TIID)...
  89. Christmas K, Patik J, Khoshnevis S, Diller K, Brothers R. Pronounced and sustained cutaneous vasoconstriction during and following cyrotherapy treatment: Role of neurotransmitters released from sympathetic nerves. Microvasc Res. 2018;115:52-57 pubmed publisher
    ..The sustained vasoconstriction that occurs following cessation of the cooling stimulus does not appear to be related to activation of post-synaptic α-adrenergic receptors or NPY Y1 receptor. ..
  90. Nätt D, Barchiesi R, Murad J, Feng J, Nestler E, Champagne F, et al. Perinatal Malnutrition Leads to Sexually Dimorphic Behavioral Responses with Associated Epigenetic Changes in the Mouse Brain. Sci Rep. 2017;7:11082 pubmed publisher
    ..One relevant target is neuropeptide Y (NPY), which regulates both stress and food-intake...
  91. Cebada Sánchez S, Insausti R, González Fuentes J, Arroyo Jimenez M, Rivas Infante E, Lagartos M, et al. Distribution of peptidergic populations in the human dentate gyrus (somatostatin [SOM-28, SOM-12] and neuropeptide Y [NPY]) during postnatal development. Cell Tissue Res. 2014;358:25-41 pubmed publisher
    ..Immunohistochemically identified neurons and fibers for somatostatin (SOM-12 and SOM-28) and neuropeptide Y (NPY) and the co-localization of SOM-28 and NPY were analyzed...
  92. Skärstrand H, Vaziri Sani F, Delli A, Törn C, Elding Larsson H, Ivarsson S, et al. Neuropeptide Y is a minor autoantigen in newly diagnosed type 1 diabetes patients. Pediatr Diabetes. 2015;16:621-8 pubmed publisher
    Autoantibodies (A) against Neuropeptide Y (NPY), was reported in 9% newly diagnosed type 1 diabetes (T1D) patients...