Gene Symbol: neuroglobin
Description: neuroglobin
Alias: neuroglobin
Species: human
Products:     neuroglobin

Top Publications

  1. Lee H, Kim D, Dan H, Wu E, Gritsko T, Cao C, et al. Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein. Mol Cell Biol. 2007;27:2103-19 pubmed
    ..Collectively, these findings indicate that NGB is a tumor suppressor that regulates and requires merlin to suppress cell proliferation. ..
  2. Nadra A, Marti M, Pesce A, Bolognesi M, Estrin D. Exploring the molecular basis of heme coordination in human neuroglobin. Proteins. 2008;71:695-705 pubmed
    b>Neuroglobin (Ngb), a recently discovered ancient heme protein, presents the typical globin fold and is around 20% identical to myoglobin (Mb). In contrast with Mb, however, its heme is hexacoordinated (6c)...
  3. Zhang C, Wang C, Deng M, Li L, Wang H, Fan M, et al. Full-length cDNA cloning of human neuroglobin and tissue expression of rat neuroglobin. Biochem Biophys Res Commun. 2002;290:1411-9 pubmed
    b>Neuroglobin is a recently discovered respiratory, porphyrin-containing protein that is expressed in the brain of mouse and human. However, the full-length cDNA sequence and genomic organization of human neuroglobin have not been reported...
  4. Hankeln T, Ebner B, Fuchs C, Gerlach F, Haberkamp M, Laufs T, et al. Neuroglobin and cytoglobin in search of their role in the vertebrate globin family. J Inorg Biochem. 2005;99:110-9 pubmed
    b>Neuroglobin and cytoglobin are two recent additions to the family of heme-containing respiratory proteins of man and other vertebrates...
  5. Kitatsuji C, Kurogochi M, Nishimura S, Ishimori K, Wakasugi K. Molecular basis of guanine nucleotide dissociation inhibitor activity of human neuroglobin by chemical cross-linking and mass spectrometry. J Mol Biol. 2007;368:150-60 pubmed
    Oxidized human neuroglobin (Ngb), a heme protein expressed in the brain, has been proposed to act as a guanine nucleotide dissociation inhibitor (GDI) for the GDP-bound form of the heterotrimeric G protein alpha-subunit (Galpha(i))...
  6. Jin K, Mao Y, Mao X, Xie L, Greenberg D. Neuroglobin expression in ischemic stroke. Stroke. 2010;41:557-9 pubmed publisher
    We investigated whether neuroglobin, a neuronal protein that protects neurons from hypoxic-ischemic injury, is upregulated in ischemic stroke...
  7. Wystub S, Laufs T, Schmidt M, Burmester T, Maas U, Saaler Reinhardt S, et al. Localization of neuroglobin protein in the mouse brain. Neurosci Lett. 2003;346:114-6 pubmed
    b>Neuroglobin is a recently discovered vertebrate oxygen-binding respiratory protein...
  8. Wakasugi K, Nakano T, Morishima I. Oxidized human neuroglobin acts as a heterotrimeric Galpha protein guanine nucleotide dissociation inhibitor. J Biol Chem. 2003;278:36505-12 pubmed
    b>Neuroglobin (Ngb) is a newly discovered vertebrate heme protein that is expressed in the brain and can reversibly bind oxygen...
  9. Xu W, Wang C, Liao Z, Zhang Y, Yu L, Wang X, et al. [Identification of interaction and interaction domains between neuroglobin and Na(+), K(+)-ATPase beta2 subunit]. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003;35:823-8 pubmed
    The pre-transformed human fetal brain cDNA library was used to screen the protein interacting with neuroglobin by using yeast two hybrid system III from ClonTech Inc...

More Information

Publications148 found, 100 shown here

  1. Wakasugi K, Morishima I. Identification of residues in human neuroglobin crucial for Guanine nucleotide dissociation inhibitor activity. Biochemistry. 2005;44:2943-8 pubmed
    b>Neuroglobin (Ngb) is a recently discovered vertebrate heme protein that is expressed in the brain and can reversibly bind oxygen...
  2. Hamdane D, Kiger L, Dewilde S, Green B, Pesce A, Uzan J, et al. The redox state of the cell regulates the ligand binding affinity of human neuroglobin and cytoglobin. J Biol Chem. 2003;278:51713-21 pubmed
    b>Neuroglobin and cytoglobin reversibly bind oxygen in competition with the distal histidine, and the observed oxygen affinity therefore depends on the properties of both ligands...
  3. Wakasugi K, Nakano T, Kitatsuji C, Morishima I. Human neuroglobin interacts with flotillin-1, a lipid raft microdomain-associated protein. Biochem Biophys Res Commun. 2004;318:453-60 pubmed
    b>Neuroglobin (Ngb) is a newly discovered vertebrate globin that is expressed in the brain and that can reversibly bind oxygen...
  4. Watanabe S, Wakasugi K. Neuroprotective function of human neuroglobin is correlated with its guanine nucleotide dissociation inhibitor activity. Biochem Biophys Res Commun. 2008;369:695-700 pubmed publisher
    Mammalian neuroglobin (Ngb) is involved in neuroprotection under oxidative stress conditions such as ischemia and reperfusion. However, the neuroprotective mechanism remains unclear...
  5. Lardinois O, Tomer K, Mason R, Deterding L. Identification of protein radicals formed in the human neuroglobin-H2O2 reaction using immuno-spin trapping and mass spectrometry. Biochemistry. 2008;47:10440-8 pubmed publisher
    b>Neuroglobin (Ngb) is a recently discovered protein that shows only minor sequence similarity with myoglobin and hemoglobin but conforms to the typical 3-over-3 alpha-helical fold characteristic of vertebrate globins...
  6. Watanabe S, Takahashi N, Uchida H, Wakasugi K. Human neuroglobin functions as an oxidative stress-responsive sensor for neuroprotection. J Biol Chem. 2012;287:30128-38 pubmed publisher
    Mammalian neuroglobin (Ngb) protects neuronal cells under conditions of oxidative stress. The mechanism underlying this function is only partly understood...
  7. Raychaudhuri S, Skommer J, Henty K, Birch N, Brittain T. Neuroglobin protects nerve cells from apoptosis by inhibiting the intrinsic pathway of cell death. Apoptosis. 2010;15:401-11 pubmed publisher
    In the past few years, overwhelming evidence has accrued that a high level of expression of the protein neuroglobin protects neurons in vitro, in animal models, and in humans, against cell death associated with hypoxic and amyloid insult...
  8. DeWilde S, Kiger L, Burmester T, Hankeln T, Baudin Creuza V, Aerts T, et al. Biochemical characterization and ligand binding properties of neuroglobin, a novel member of the globin family. J Biol Chem. 2001;276:38949-55 pubmed
    b>Neuroglobin is a recently discovered member of the globin superfamily that is suggested to enhance the O(2) supply of the vertebrate brain...
  9. Ezhevskaya M, Trandafir F, Moens L, Dewilde S, Van Doorslaer S. EPR investigation of the role of B10 phenylalanine in neuroglobin - evidence that B10Phe mediates structural changes in the heme region upon disulfide-bridge formation. J Inorg Biochem. 2011;105:1131-7 pubmed publisher
    The function of neuroglobin, a member of the vertebrate globin family, is still unknown...
  10. Burmester T, Weich B, Reinhardt S, Hankeln T. A vertebrate globin expressed in the brain. Nature. 2000;407:520-3 pubmed
    ..This protein is predominantly expressed in the brain, and therefore we have called it neuroglobin. Mouse neuroglobin is a monomer with a high oxygen affinity (half saturation pressure, P50 approximately 2 torr)..
  11. Pesce A, Dewilde S, Nardini M, Moens L, Ascenzi P, Hankeln T, et al. Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity. Structure. 2003;11:1087-95 pubmed
    b>Neuroglobin, mainly expressed in vertebrate brain and retina, is a recently identified member of the globin superfamily...
  12. Hamdane D, Kiger L, Dewilde S, Green B, Pesce A, Uzan J, et al. Coupling of the heme and an internal disulfide bond in human neuroglobin. Micron. 2004;35:59-62 pubmed
    b>Neuroglobin displays a hexacoordination His-Fe-His in the absence of external ligands such as oxygen. The observed oxygen affinity therefore depends on the binding rates of both oxygen and the competing distal histidine...
  13. Mendoza V, Klein D, Ichii H, Ribeiro M, Ricordi C, Hankeln T, et al. Protection of islets in culture by delivery of oxygen binding neuroglobin via protein transduction. Transplant Proc. 2005;37:237-40 pubmed
    ..A promising candidate for cytoprotection against oxygen deprivation is neuroglobin (Ngb)...
  14. Hamdane D, Kiger L, Dewilde S, Uzan J, Burmester T, Hankeln T, et al. Hyperthermal stability of neuroglobin and cytoglobin. FEBS J. 2005;272:2076-84 pubmed
    b>Neuroglobin (Ngb) and cytoglobin (Cygb), recent additions to the globin family, display a hexa-coordinated (bis-histidyl) heme in the absence of external ligands...
  15. Watanabe S, Wakasugi K. Zebrafish neuroglobin is a cell-membrane-penetrating globin. Biochemistry. 2008;47:5266-70 pubmed publisher
    b>Neuroglobin (Ngb) is a recently discovered vertebrate heme protein that is expressed in the brain and can reversibly bind oxygen...
  16. Hamdane D, Lechauve C, Marden M, Golinelli Pimpaneau B. Pseudo-merohedral twinning in monoclinic crystals of wild-type human brain neuroglobin. Acta Crystallogr D Biol Crystallogr. 2009;65:388-92 pubmed publisher
    ..crystallization and successful structure determination by molecular replacement of wild-type human brain neuroglobin at 1.8 A resolution is reported...
  17. Singh S, Singh A, Garg G, Rizvi S. Fisetin as a caloric restriction mimetic protects rat brain against aging induced oxidative stress, apoptosis and neurodegeneration. Life Sci. 2018;193:171-179 pubmed publisher
    ..The present study suggests that fisetin supplementation may provide neuroprotection against aging-induced oxidative stress, apoptotic cell death, neuro-inflammation, and neurodegeneration in rat brain. ..
  18. Garg G, Singh S, Singh A, Rizvi S. N-acetyl L-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. Can J Physiol Pharmacol. 2018;: pubmed publisher
    ..The present findings support a neuroprotective role of NAC which may provide its therapeutic implication in controlling age related neurological disorders. ..
  19. Shakir N, Satyanarayan A, Eastman J, Greenberg B, Lemack G. Assessment of Renal Deterioration and Associated Risk Factors in Patients With Multiple Sclerosis. Urology. 2019;123:76-80 pubmed publisher
    ..Using more liberal criteria, DO was associated with deterioration, suggesting that study of the impact of more aggressive control of DO in this population may be warranted. ..
  20. Niu J, Hu R. Role of flunarizine hydrochloride in secondary brain injury following intracerebral hemorrhage in rats. Int J Immunopathol Pharmacol. 2017;:394632017742224 pubmed publisher
    ..The expressions of glial cell line-derived neurotrophic factor (GDNF), neuroglobin (NGB), and p-AKT were increased after flunarizine hydrochloride treatment in ICH rats...
  21. Qin H, Guo Y, Zhang C, Zhang L, Li M, Guan P. The expression of neuroglobin in astrocytoma. Brain Tumor Pathol. 2012;29:10-6 pubmed publisher
    b>Neuroglobin (NGB) is a characterized heme globin that is widely expressed in the vertebrate central and peripheral nervous system as well as retina and endocrine tissues...
  22. Wang J, Jia Y, Li G, Wang B, Zhou T, Zhu L, et al. The Dopamine Receptor D3 Regulates Lipopolysaccharide-Induced Depressive-Like Behavior in Mice. Int J Neuropsychopharmacol. 2018;21:448-460 pubmed publisher
    ..These findings provide a relevant mechanism for D3R in LPS-induced depressive-like behavior via its mediation of proinflammatory cytokines and potential cross-effects between BDNF and the ERK1/2-CREB signaling pathway. ..
  23. Sawai H, Makino M, Mizutani Y, Ohta T, Sugimoto H, Uno T, et al. Structural characterization of the proximal and distal histidine environment of cytoglobin and neuroglobin. Biochemistry. 2005;44:13257-65 pubmed
    Cytoglobin (Cgb) and neuroglobin (Ngb) are the first examples of hexacoordinated globins from humans and other vertebrates in which a histidine (His) residue at the sixth position of the heme iron is an endogenous ligand in both the ..
  24. Shang A, Yang Y, Wang H, Wang J, Hang X, Wang Z, et al. Upregulation of neuroglobin expression and changes in serum redox indices in a rat model of middle cerebral artery occlusion. Mol Med Rep. 2015;12:1693-8 pubmed publisher
    b>Neuroglobin (NGB) is a recently identified protein, which is localized in the neurons and retinal cells of the central and peripheral nervous systems in vertebrates...
  25. da Conceição R, de Souza J, de Oliveira K, Romano R, de Barros Maciel R, Dias da Silva M, et al. Evaluation of neuroglobin and cytoglobin expression in adult rats exposed to silver nanoparticles during prepubescence. Metab Brain Dis. 2019;: pubmed publisher
    ..the aim of this study was to evaluate the effect of AgNP exposure on the gene and protein expression levels of Neuroglobin (Ngb) and Cytoglobin (Cygb), in the rat cortex, hippocampus and cerebellum...
  26. Salehi Pourmehr H, Rahbarghazi R, Mahmoudi J, Roshangar L, Chapple C, Hajebrahimi S, et al. Intra-bladder wall transplantation of bone marrow mesenchymal stem cells improved urinary bladder dysfunction following spinal cord injury. Life Sci. 2019;221:20-28 pubmed publisher
    ..042). Our study added a notion that urinary dysfunction associated with SCI, was improved following direct injection of autologous BM-MSC transplantation to bladder wall in the chronic phase of SCI injury. ..
  27. Higley A, Spiller K, Grundt P, Newman A, Kiefer S, Xi Z, et al. PG01037, a novel dopamine D3 receptor antagonist, inhibits the effects of methamphetamine in rats. J Psychopharmacol. 2011;25:263-73 pubmed publisher
  28. Guimarães B, Hamdane D, Lechauve C, Marden M, Golinelli Pimpaneau B. The crystal structure of wild-type human brain neuroglobin reveals flexibility of the disulfide bond that regulates oxygen affinity. Acta Crystallogr D Biol Crystallogr. 2014;70:1005-14 pubmed publisher
    b>Neuroglobin plays an important function in the supply of oxygen in nervous tissues...
  29. Fabrizius A, Andre D, Laufs T, Bicker A, Reuss S, Porto E, et al. Critical re-evaluation of neuroglobin expression reveals conserved patterns among mammals. Neuroscience. 2016;337:339-354 pubmed publisher
    b>Neuroglobin (Ngb) is a respiratory protein that is almost exclusively expressed in the vertebrate nervous system. Despite many years of research, the exact function and even the expression sites of Ngb are still a matter of debate...
  30. Xue L, Li X, Ren H, Wu F, Li M, Wang B, et al. The dopamine D3 receptor regulates the effects of methamphetamine on LPS-induced cytokine production in murine mast cells. Immunobiology. 2015;220:744-52 pubmed publisher
    ..Our results suggest that METH regulates mast cell released cytokines production in an LPS-induced mouse model via the D3R. ..
  31. Chen L, Wang L, Zhuo Q, Zhang Q, Chen F, Li L, et al. Effect of Shenmai injection on cognitive function after cardiopulmonary bypass in cardiac surgical patients: a randomized controlled trial. BMC Anesthesiol. 2018;18:142 pubmed publisher
    ..The serum levels of neuroglobin (Ngb), hypoxia-inducible factor-1α (HIF-1α), and neuron-specific enolase (NSE) were measured at 30 min after ..
  32. Cheng S, Li N, Jiang L, Li Y, Xu B, Zhou W. Biodegradation of metal complex Naphthol Green B and formation of iron-sulfur nanoparticles by marine bacterium Pseudoalteromonas sp CF10-13. Bioresour Technol. 2019;273:49-55 pubmed publisher
    ..Accordingly, this study provided a cost-effective and eco-friendly biodegradation method to refractory NGB, further promoting the understanding of dye resources recovery. ..
  33. Tiwari P, Chapagain P, Uren A. Investigating molecular interactions between oxidized neuroglobin and cytochrome c. Sci Rep. 2018;8:10557 pubmed publisher
    The formation of a complex between neuroglobin (Ngb) and cytochrome c (Cyt c) has an important biological role in preventing apoptosis...
  34. Gan S, Wong L, Wong J, Tan E. Fucosterol exerts protection against amyloid β-induced neurotoxicity, reduces intracellular levels of amyloid β and enhances the mRNA expression of neuroglobin in amyloid β-induced SH-SY5Y cells. Int J Biol Macromol. 2019;121:207-213 pubmed publisher
    ..Recent evidences also highlighted the importance of neuroglobin (Ngb) in ameliorating AD...
  35. Lee D, Dillon B, Lemack G. Adult Onset Nocturnal Enuresis: Identifying Causes, Cofactors and Impact on Quality of Life. Low Urin Tract Symptoms. 2018;10:292-296 pubmed publisher
    ..Nocturnal enuresis is associated with multiple possible co-factors in all populations with majority reporting use of sedating medications. NE is associated with significant symptom bother and impacts greatly on QoL. ..
  36. Faghy M, Lomax M, Brown P. Active recovery strategy and lactate clearance in elite swimmers. J Sports Med Phys Fitness. 2018;: pubmed publisher
    ..23 ± 0.14 min) and NGB (2.22 ± 0.13 min, P>0.05). Despite similar performance, individually prescribed recovery strategy with a physiological basis will preserve repeated exercise performance performed on the same day. ..
  37. Levine Y, Tuttle M, Rosenberg M, Goldberg R, Matos J, Samuel M, et al. Prevalence and outcomes of patients receiving implantable cardioverter-defibrillators for primary prevention not based on guidelines. Am J Cardiol. 2015;115:1539-44 pubmed publisher
    ..These results suggest that there is little need to rush into implanting ICDs during these waiting periods. ..
  38. Lee T, Yoon K, LEE J. Cultivation of Caenorhabditis elegans in Three Dimensions in the Laboratory. J Vis Exp. 2016;: pubmed publisher
    ..These can help us to understand the overlying evolutionary relevance of the physiology and behavior of C. elegans we observe in the laboratory. ..
  39. Liu G, Wu H, Li Z. Study on the correlation of changes of IGF-1, GH, and NGB levels and NBNA score in neonates with hypoxic ischemic encephalopathy. Eur Rev Med Pharmacol Sci. 2018;22:3173-3181 pubmed publisher
    ..the correlation between dynamic changes of serum insulin-like growth factor 1 (IGF-1), growth hormone (GH), neuroglobin (NGB), and neonatal behavioral neurological assessment (NBNA) scores in different periods in neonates with ..
  40. Ding Y, Jiang M, Jiang W, Su Y, Zhou H, Hu X, et al. Expression, purification, and characterization of recombinant human flotillin-1 in Escherichia coli. Protein Expr Purif. 2005;42:137-45 pubmed
    ..flotillin-1 and the native flotillin-1 from human erythrocyte membranes with c-Cbl-associated protein or neuroglobin was confirmed, which demonstrated that the recombinant proteins were functional active...
  41. Galaj E, Harding W, Ranaldi R. Dopamine D1 and D3 receptor interactions in cocaine reward and seeking in rats. Psychopharmacology (Berl). 2016;233:3881-3890 pubmed
    ..This suggests an interaction between dopamine D1 and D3 receptors in cocaine-related behaviors. ..
  42. Wu M, Chen N, Huang C, He Y, Zhao Y, Chen X, et al. Effect of Low Temperature on Globin Expression, Respiratory Metabolic Enzyme Activities, and Gill Structure of Litopenaeus vannamei. Biochemistry (Mosc). 2017;82:844-851 pubmed publisher
    ..The cDNA sequences of two oxygen-carrying proteins, cytoglobin (Cygb) and neuroglobin (Ngb), were isolated. Protein structure analysis revealed that both proteins share a globin superfamily domain...
  43. Xiong X, Pan F, Chen R, Hu D, Qiu X, Li C, et al. Neuroglobin boosts axon regeneration during ischemic reperfusion via p38 binding and activation depending on oxygen signal. Cell Death Dis. 2018;9:163 pubmed publisher
    ..Here we reported that neuroglobin (Ngb), a novel oxygen-binding or sensor protein existing predominantly in neurons or brains, functions as a ..
  44. Zhou X, Xia Y, Zhao Y, Gu W, Xiao X, Bai X, et al. [Estradiol significantly increases the expression of antioxidant enzymes in osteoporotic rats and osteoblasts in vitro]. Nan Fang Yi Ke Da Xue Xue Bao. 2018;38:402-408 pubmed
  45. Pesce A, Nardini M, Dewilde S, Ascenzi P, Burmester T, Hankeln T, et al. Human neuroglobin: crystals and preliminary X-ray diffraction analysis. Acta Crystallogr D Biol Crystallogr. 2002;58:1848-50 pubmed
    b>Neuroglobin, a recently discovered member of the haemoglobin superfamily, is primarily expressed in the brain of humans and other vertebrates, where it has been proposed to enhance O(2) supply in response to hypoxia or ischaemia, ..
  46. Zara S, Porzionato A, De Colli M, Macchi V, Cataldi A, De Caro R, et al. Human carotid body neuroglobin, vascular endothelial growth factor and inducible nitric oxide synthase expression in heroin addiction. Histol Histopathol. 2013;28:903-11 pubmed publisher
    ..slides were treated with Mallory Trichrome staining or used for immunohistochemical analysis to detect Neuroglobin (NGB), Hypoxia Inducible Factor-1 (HIF-1α), Vascular Endothelial Growth Factor (VEGF), Inducible Nitric Oxide ..
  47. Cai B, Li W, Mao X, Winters A, Ryou M, Liu R, et al. Neuroglobin Overexpression Inhibits AMPK Signaling and Promotes Cell Anabolism. Mol Neurobiol. 2016;53:1254-65 pubmed publisher
    b>Neuroglobin (Ngb) is a recently discovered globin with preferential localization to neurons...
  48. Maglione A, Taranto P, Hamermesz B, Souza J, Cafarchio E, Ogihara C, et al. Impact of swimming exercise on inflammation in medullary areas of sympathetic outflow control in spontaneously hypertensive rats. Metab Brain Dis. 2018;33:1649-1660 pubmed publisher
    ..The g.e. of cycloxygenase-2 (COX-2), interleukin 6 (IL-6), interleukin 10 (IL-10), AT-1 receptor (AT-1r), neuroglobin (Ngb) and cytoglobin (Ctb) in cNTS and RVLM was carried out by qPCR. We observed that COX-2 g.e...
  49. Corti P, Ieraci M, Tejero J. Characterization of zebrafish neuroglobin and cytoglobins 1 and 2: Zebrafish cytoglobins provide insights into the transition from six-coordinate to five-coordinate globins. Nitric Oxide. 2016;53:22-34 pubmed publisher
    b>Neuroglobin (Ngb) and cytoglobin (Cygb) are two six-coordinate heme proteins of unknown physiological function...
  50. Fiocchetti M, Cipolletti M, Leone S, Naldini A, Carraro F, Giordano D, et al. Neuroglobin in Breast Cancer Cells: Effect of Hypoxia and Oxidative Stress on Protein Level, Localization, and Anti-Apoptotic Function. PLoS ONE. 2016;11:e0154959 pubmed publisher
    The over-expression of human neuroglobin (NGB), a heme-protein preferentially expressed in the brain, displays anti-apoptotic effects against hypoxic/ischemic and oxidative stresses enhancing neuron survival...
  51. Gopalakrishnan V, Purushothaman P, Bhaskar A. Proteomic analysis of plasma proteins in diabetic retinopathy patients by two dimensional electrophoresis and MALDI-Tof-MS. J Diabetes Complications. 2015;29:928-36 pubmed publisher
    ..protein spots RBP1 (retinol-binding protein 1), NUD10 (Diphosphoinositol polyphosphohydrolase 3 alpha), NGB (neuroglobin) were down regulated and HBG2 (hemoglobin) and BY55 (CD 160 antigen) were upregulated in diabetic retinopathy...
  52. Dietz G. Protection by neuroglobin and cell-penetrating peptide-mediated delivery in vivo: a decade of research. Comment on Cai et al: TAT-mediated delivery of neuroglobin protects against focal cerebral ischemia in mice. Exp Neurol. 2011; 227(1): 224-31. Exp Neurol. 2011;231:1-10 pubmed publisher
    Over the last decade, numerous studies have suggested that neuroglobin is able to protect against the effects of ischemia. However, such results have mostly been based on models using transgenic overexpression or viral delivery...
  53. Chang J, Ciais P, Viovy N, Vuichard N, Sultan B, Soussana J. The greenhouse gas balance of European grasslands. Glob Chang Biol. 2015;21:3748-61 pubmed publisher
  54. Vorasubin N, Hosokawa S, Hosokawa K, Ishiyama G, Ishiyama A, Lopez I. Neuroglobin immunoreactivity in the human cochlea. Brain Res. 2016;1630:56-63 pubmed publisher
    b>Neuroglobin (Ngb) is an oxygen-binding protein with a demonstrated role in endogenous neuroprotective mechanisms...
  55. Wen H, Liu L, Zhan L, Liang D, Li L, Liu D, et al. Neuroglobin mediates neuroprotection of hypoxic postconditioning against transient global cerebral ischemia in rats through preserving the activity of Na+/K+ ATPases. Cell Death Dis. 2018;9:635 pubmed publisher
    ..However, its molecular mechanisms have not yet been adequately elucidated. Neuroglobin (Ngb) is an endogenous neuroprotectant with hypoxia-inducible property, and its role in experimental stroke has ..
  56. Yu Z, Cheng C, Liu Y, Liu N, Lo E, Wang X. Neuroglobin promotes neurogenesis through Wnt signaling pathway. Cell Death Dis. 2018;9:945 pubmed publisher
    b>Neuroglobin (Ngb) has been demonstrated by our lab and others to be neuroprotective against neurological disorders including stroke. However, the roles of Ngb in neurogenesis remain elusive...
  57. Paltrinieri L, Di Rocco G, Battistuzzi G, Borsari M, Sola M, Ranieri A, et al. Computational evidence support the hypothesis of neuroglobin also acting as an electron transfer species. J Biol Inorg Chem. 2017;22:615-623 pubmed publisher
    b>Neuroglobin (Ngb) is a recently identified hexa-coordinated globin, expressed in the nervous system of humans...
  58. Redshaw J, Lenherr S, Elliott S, Stoffel J, Rosenbluth J, Presson A, et al. Protocol for a randomized clinical trial investigating early sacral nerve stimulation as an adjunct to standard neurogenic bladder management following acute spinal cord injury. BMC Urol. 2018;18:72 pubmed publisher # NCT03083366 1/27/2017. ..
  59. Morozov A, Roach J, Kotzer M, Chatfield D. A possible mechanism for redox control of human neuroglobin activity. J Chem Inf Model. 2014;54:1997-2003 pubmed publisher
    b>Neuroglobin (Ngb) promotes neuron survival under hypoxic/ischemic conditions. In vivo and in vitro assays provide evidence for redox-regulated functioning of Ngb...
  60. Liu A, Brittain T. A Futile Redox Cycle Involving Neuroglobin Observed at Physiological Temperature. Int J Mol Sci. 2015;16:20082-94 pubmed publisher
    Previous studies identifying the potential anti-apoptotic role of neuroglobin raise the question as to how cells might employ neuroglobin to avoid the apoptotic impact of acute hypoxia whilst also avoiding chronic enhancement of tumour ..
  61. Huang M, Kwon S, Oyamada Y, Rajagopal L, Miyauchi M, Meltzer H. Dopamine D3 receptor antagonism contributes to blonanserin-induced cortical dopamine and acetylcholine efflux and cognitive improvement. Pharmacol Biochem Behav. 2015;138:49-57 pubmed publisher
    ..3mg/kg), ameliorated the scPCP-induced NOR deficit in rats. These results suggest that D3 receptor blockade may contribute to the ability of blonanserin to increase cortical DA and ACh efflux, as well as to restore NOR and improve CIAS. ..
  62. Raup V, Eswara J, Weese J, Potretzke A, Brandes S. Urinary-cutaneous Fistulae in Patients With Neurogenic Bladder. Urology. 2015;86:1222-6 pubmed publisher
    ..UCF repairs in patients with NGB are a challenge to manage. Patients who undergo surgical repair of their fistula are likely to require repeat repairs with eventual need for a permanent urinary diversion. ..
  63. Zhang W, Ma C, Su Z, Bai Y. Resonance Rayleigh Scattering Spectra of an Ion-Association Complex of Naphthol Green B-Chitosan System and Its Application in the Highly Sensitive Determination of Chitosan. Mar Drugs. 2016;14: pubmed publisher
    ..0, and the molecular weight was found to have no statistical significance. This method has been applied to assay two CTS samples and obtained good recovery and reproducibility. ..
  64. Azarov I, Wang L, Rose J, Xu Q, Huang X, Belanger A, et al. Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning. Sci Transl Med. 2016;8:368ra173 pubmed
    ..potential treatment paradigm for CO poisoning, based on near-irreversible binding of CO by an engineered human neuroglobin (Ngb). Ngb is a six-coordinate hemoprotein, with the heme iron coordinated by two histidine residues...
  65. Nuzzo M, Fiocchetti M, Totta P, Melone M, Cardinale A, Fusco F, et al. Huntingtin polyQ Mutation Impairs the 17?-Estradiol/Neuroglobin Pathway Devoted to Neuron Survival. Mol Neurobiol. 2017;54:6634-6646 pubmed publisher
    ..that E2 induces the up-regulation of two anti-apoptotic and neuroprotectant proteins: huntingtin (HTT) and neuroglobin (NGB). Here, we investigate the role of this up-regulation...
  66. Chen X, Liu Y, Zhang L, Zhu P, Zhu H, Yang Y, et al. Long-term neuroglobin expression of human astrocytes following brain trauma. Neurosci Lett. 2015;606:194-9 pubmed publisher
    b>Neuroglobin (Ngb), a 17 kDa monomeric protein, was initially described as a vertebrate oxygen-binding heme protein in 2000 and detected in metabolically active organs or cells, like the brain, peripheral nervous system as well as certain ..
  67. Nasgashio R, Sato Y, Matsumoto T, Kageyama T, Hattori M, Iyoda A, et al. The balance between the expressions of hASH1 and HES1 differs between large cell neuroendocrine carcinoma and small cell carcinoma of the lung. Lung Cancer. 2011;74:405-10 pubmed publisher
  68. Ren C, Wang P, Wang B, Li N, Li W, Zhang C, et al. Limb remote ischemic per-conditioning in combination with post-conditioning reduces brain damage and promotes neuroglobin expression in the rat brain after ischemic stroke. Restor Neurol Neurosci. 2015;33:369-79 pubmed publisher
    ..The infarct volume, motor function, and the expression of neuroglobin (Ngb) were measured at different durations after reperfusion...
  69. Xue L, Chen H, Lu K, Huang J, Duan H, Zhao Y. Clinical significance of changes in serum neuroglobin and HIF-1? concentrations during the early-phase of acute ischemic stroke. J Neurol Sci. 2017;375:52-57 pubmed publisher
    b>Neuroglobin (NGB) has been described as a neuroprotective agent in cerebral ischemia, hypoxia inducible factor (HIF) has shown an important role in modulating hypoxic and ischemic injury, and therefore they have the potential to impact ..
  70. Fang H, Lu B, Wang X, Zheng L, Sun K, Cai W. Application of data mining techniques to explore predictors of upper urinary tract damage in patients with neurogenic bladder. Braz J Med Biol Res. 2017;50:e6638 pubmed publisher
    ..8%, and the area under curve was 0.901 (95%CI=0.844-0.958), suggesting that the decision tree model might provide a new and convenient way to screen UUTD for NGB patients in both undeveloped and developing areas...
  71. Fiocchetti M, Cipolletti M, Ascenzi P, Marino M. Dissecting the 17?-estradiol pathways necessary for Neuroglobin anti-apoptotic activity in breast cancer. J Cell Physiol. 2017;: pubmed publisher
    b>Neuroglobin (NGB) is a relatively recent discovered monomeric heme-protein, which behave in neurons as a sensor of injuring stimuli including oxidative stress, hypoxia, and neurotoxicity...
  72. Defoor W, Reddy P, Reed M, VanderBrink B, Jackson E, Zhang B, et al. Results of a prospective randomized control trial comparing hydrophilic to uncoated catheters in children with neurogenic bladder. J Pediatr Urol. 2017;13:373.e1-373.e5 pubmed publisher
    ..HCs may decrease the risk of UTI in children with NGB. Urethral complications were low in both groups. Most HC patients were pleased but some found the slippery coating difficult to handle. ..
  73. Cai H, Zheng S, Cai B, Yao P, Ding C, Chen F, et al. Neuroglobin as a Novel Biomarker for Predicting Poor Outcomes in Aneurysmal Subarachnoid Hemorrhage. World Neurosurg. 2018;116:e258-e265 pubmed publisher
    b>Neuroglobin (Ngb) has a high affinity for oxygen and helps prevent hypoxic-ischemic brain damage. In this study we analyzed the relationship between Ngb levels and clinical outcomes of aneurysmal subarachnoid hemorrhage (aSAH)...
  74. Fiocchetti M, Nuzzo M, Totta P, Acconcia F, Ascenzi P, Marino M. Neuroglobin, a pro-survival player in estrogen receptor α-positive cancer cells. Cell Death Dis. 2014;5:e1449 pubmed publisher
    Recently, we reported that human neuroglobin (NGB) is a new player in the signal transduction pathways that lead to 17β-estradiol (E2)-induced neuron survival...
  75. Chan R, Scovell J, Jeng Z, Rajanahally S, Boone T, Khavari R. The fate of transitional urology patients referred to a tertiary transitional care center. Urology. 2014;84:1544-8 pubmed publisher
    ..This study emphasizes the necessity for a dedicated adult urologic team in conjunction with a comprehensive team to care for these complex patients because their urologic care and needs may vary significantly from their childhood. ..
  76. Ye Q, Sun Y, Wu Y, Gao Y, Li Z, Li W, et al. Pichia pastoris Production of Tat-NGB and Its Neuroprotection on Rat Pheochromocytoma Cells. Mol Biotechnol. 2016;58:22-9 pubmed publisher
    b>Neuroglobin (NGB) is a newly discovered neuroprotector and mainly localized in the neurons and retinal cells of the central and peripheral nervous systems in vertebrates, and its prokaryotic expression protein of which fused with HIV-1 ..
  77. Zhu L, Huang L, Wen Q, Wang T, Qiao L, Jiang L. Recombinant human erythropoietin offers neuroprotection through inducing endogenous erythropoietin receptor and neuroglobin in a neonatal rat model of periventricular white matter damage. Neurosci Lett. 2017;650:12-17 pubmed publisher
    ..The purpose of this study was to evaluate the levels of erythropoietin receptor (EPOR) and neuroglobin (Ngb) in a neonatal rat model of periventricular white matter damage (PWMD), and to identify the relationship ..
  78. Gomelsky A, Lemack G, Castano Botero J, Lee R, Myers J, Granitsiotis P, et al. Current and future international patterns of care of neurogenic bladder after spinal cord injury. World J Urol. 2018;36:1613-1619 pubmed publisher
    ..Future research efforts should focus on improving access to diagnostic modalities, supplies, and specialists in these areas. ..
  79. Liu H, Li L, He B, Gao S, Wen G, Lin Y. Neuroglobin is capable of self-oxidation of methionine64 introduced at the heme axial position. Dalton Trans. 2018;47:10847-10852 pubmed publisher
    b>Neuroglobin (Ngb), with its physiological role not fully understood, was found to be capable of self-oxidation of methionine64 introduced at the heme axial position (H64M Ngb), adopting a high-spin heme state and producing both ..
  80. Zhang W, Tian Z, Sha S, Cheng L, Philipsen S, Tan Un K. Functional and sequence analysis of human neuroglobin gene promoter region. Biochim Biophys Acta. 2011;1809:236-44 pubmed publisher
    b>Neuroglobin (Ngb), a recently found oxygen-binding protein belonging to the vertebrate globin family, is mainly expressed in neurons of brains and eyes...
  81. Colloc h N, Sacquin Mora S, Avella G, Dhaussy A, Prangé T, Vallone B, et al. Determinants of neuroglobin plasticity highlighted by joint coarse-grained simulations and high pressure crystallography. Sci Rep. 2017;7:1858 pubmed publisher
    ..Here we detail the structural response to pressure of neuroglobin (Ngb), a hexacoordinate globin likely to be involved in neuroprotection...
  82. Garofalo T, Ferri A, Sorice M, Azmoon P, Grasso M, Mattei V, et al. Neuroglobin overexpression plays a pivotal role in neuroprotection through mitochondrial raft-like microdomains in neuroblastoma SK-N-BE2 cells. Mol Cell Neurosci. 2018;88:167-176 pubmed publisher
    Since stressing conditions induce a relocalization of endogenous human neuroglobin (NGB) to mitochondria, this research is aimed to evaluate the protective role of NGB overexpression against neurotoxic stimuli, through mitochondrial ..
  83. Tiso M, Tejero J, Basu S, Azarov I, Wang X, Simplaceanu V, et al. Human neuroglobin functions as a redox-regulated nitrite reductase. J Biol Chem. 2011;286:18277-89 pubmed publisher
    b>Neuroglobin is a highly conserved hemoprotein of uncertain physiological function that evolved from a common ancestor to hemoglobin and myoglobin...
  84. Sugitani K, Koriyama Y, Ogai K, Wakasugi K, Kato S. A Possible Role of Neuroglobin in the Retina After Optic Nerve Injury: A Comparative Study of Zebrafish and Mouse Retina. Adv Exp Med Biol. 2016;854:671-5 pubmed publisher
    b>Neuroglobin (Ngb) is a new member of the family of heme proteins and is specifically expressed in neurons of the central and peripheral nervous systems in all vertebrates...
  85. Ascenzi P, di Masi A, Leboffe L, Fiocchetti M, Nuzzo M, Brunori M, et al. Neuroglobin: From structure to function in health and disease. Mol Aspects Med. 2016;52:1-48 pubmed publisher
    In 2000, the third member of the globin family was discovered in human and mouse brain and named neuroglobin (Ngb)...
  86. Wang Y, Peng Q, Deng S, Chen C, Wu L, Huang L, et al. Hemin protects against oxygen-glucose deprivation-induced apoptosis activation via neuroglobin in SH-SY5Y cells. Neurochem Res. 2017;42:2208-2217 pubmed publisher
    ..Cell viability and apoptotic activation were detected after hemin administration combined with neuroglobin (Nqb), thioredoxin-1, peroxiredoxin-2, or heme oxygenase-1 siRNA transient transfection...
  87. Laufs T, Wystub S, Reuss S, Burmester T, Saaler Reinhardt S, Hankeln T. Neuron-specific expression of neuroglobin in mammals. Neurosci Lett. 2004;362:83-6 pubmed
    b>Neuroglobin, a vertebrate oxygen-binding protein, is expressed in many regions of the adult brain...
  88. Chuang P, Conley Y, Poloyac S, Okonkwo D, Ren D, Sherwood P, et al. Neuroglobin genetic polymorphisms and their relationship to functional outcomes after traumatic brain injury. J Neurotrauma. 2010;27:999-1006 pubmed publisher
    b>Neuroglobin has shown rich neuroprotective effects against cerebral hypoxia, and therefore has the potential to impact outcomes after traumatic brain injury (TBI)...
  89. Cardinale A, Fusco F, Paldino E, Giampà C, Marino M, Nuzzo M, et al. Localization of neuroglobin in the brain of R6/2 mouse model of Huntington's disease. Neurol Sci. 2018;39:275-285 pubmed publisher
    b>Neuroglobin (Ngb) is expressed in the central and peripheral nervous system, cerebrospinal fluid, retina, and endocrine tissues where it is involved in binding O2 and other gasotransmitters...
  90. Picotti P, Dewilde S, Fago A, Hundahl C, De Filippis V, Moens L, et al. Unusual stability of human neuroglobin at low pH--molecular mechanisms and biological significance. FEBS J. 2009;276:7027-39 pubmed publisher
    b>Neuroglobin (Ngb) is a recently discovered globin that is predominantly expressed in the brain, retina and other nerve tissues of human and other vertebrates...
  91. D Aprile A, Scrima R, Quarato G, Tataranni T, Falzetti F, Di Ianni M, et al. Hematopoietic stem/progenitor cells express myoglobin and neuroglobin: adaptation to hypoxia or prevention from oxidative stress?. Stem Cells. 2014;32:1267-77 pubmed publisher
    ..01). A search for other Mb-related globins unveiled significant expression of neuroglobin (Ngb) but not of cytoglobin...
  92. Tam K, Chan P, Zhang W, Law P, Tian Z, Fung Chan G, et al. Identification of a novel distal regulatory element of the human Neuroglobin gene by the chromosome conformation capture approach. Nucleic Acids Res. 2017;45:115-126 pubmed publisher
    b>Neuroglobin (NGB) is predominantly expressed in the brain and retina. Studies suggest that NGB exerts protective effects to neuronal cells and is implicated in reducing the severity of stroke and Alzheimer's disease...