neurofascin

Summary

Gene Symbol: neurofascin
Description: neurofascin
Alias: NRCAML, neurofascin, neurofascin homolog
Species: human
Products:     neurofascin

Top Publications

  1. Volkmer H, Hassel B, Wolff J, Frank R, Rathjen F. Structure of the axonal surface recognition molecule neurofascin and its relationship to a neural subgroup of the immunoglobulin superfamily. J Cell Biol. 1992;118:149-61 pubmed
    The chick axon-associated surface glycoprotein neurofascin is implicated in axonal growth and fasciculation as revealed by antibody perturbation experiments. Here we report the complete cDNA sequence of neurofascin...
  2. Charles P, Tait S, Faivre Sarrailh C, Barbin G, Gunn Moore F, Denisenko Nehrbass N, et al. Neurofascin is a glial receptor for the paranodin/Caspr-contactin axonal complex at the axoglial junction. Curr Biol. 2002;12:217-20 pubmed
    ..There has been intense speculation that an oligodendroglial isoform of the cell adhesion molecule neurofascin, NF155, expressed at the paranodal loop might be the glial receptor for the paranodin/Caspr-contactin complex, ..
  3. Zhang X, Davis J, Carpenter S, Bennett V. Structural requirements for association of neurofascin with ankyrin. J Biol Chem. 1998;273:30785-94 pubmed
    This paper presents the first structural analysis of the cytoplasmic domain of neurofascin, which is highly conserved among the L1CAM family of cell adhesion molecules, and describes sequence requirements for neurofascin-ankyrin ..
  4. Hortsch M. The L1 family of neural cell adhesion molecules: old proteins performing new tricks. Neuron. 1996;17:587-93 pubmed
  5. Volkmer H, Leuschner R, Zacharias U, Rathjen F. Neurofascin induces neurites by heterophilic interactions with axonal NrCAM while NrCAM requires F11 on the axonal surface to extend neurites. J Cell Biol. 1996;135:1059-69 pubmed
    b>Neurofascin and NrCAM are two axon-associated transmembrane glycoproteins belonging to the L1 subgroup of the Ig superfamily. In this study, we have analyzed the interaction of both proteins using neurite outgrowth and binding assays...
  6. Davis J, Lambert S, Bennett V. Molecular composition of the node of Ranvier: identification of ankyrin-binding cell adhesion molecules neurofascin (mucin+/third FNIII domain-) and NrCAM at nodal axon segments. J Cell Biol. 1996;135:1355-67 pubmed
    b>Neurofascin, NrCAM, L1, and NgCAM are a family of Ig/FNIII cell adhesion molecules that share ankyrin-binding activity in their cytoplasmic domains, and are candidates to form membrane-spanning complexes with members of the ankyrin ..
  7. Volkmer H, Zacharias U, Nörenberg U, Rathjen F. Dissection of complex molecular interactions of neurofascin with axonin-1, F11, and tenascin-R, which promote attachment and neurite formation of tectal cells. J Cell Biol. 1998;142:1083-93 pubmed
    b>Neurofascin is a member of the L1 subgroup of the Ig superfamily that promotes axon outgrowth by interactions with neuronal NgCAM-related cell adhesion molecule (NrCAM)...
  8. Ratcliffe C, Westenbroek R, Curtis R, Catterall W. Sodium channel beta1 and beta3 subunits associate with neurofascin through their extracellular immunoglobulin-like domain. J Cell Biol. 2001;154:427-34 pubmed
    ..We show here that beta1 subunits associate with neurofascin, a neuronal cell adhesion molecule that plays a key role in the assembly of nodes of Ranvier...
  9. Briani C, Salvalaggio A, Ruiz M, Cacciavillani M, Rinaldi F, Callegari I, et al. Tongue tremor in neurofascin-155 IgG4 seropositive chronic inflammatory polyradiculoneuropathy. J Neuroimmunol. 2019;330:178-180 pubmed publisher
    Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) with anti-neurofascin-155 antibodies is a subgroup of CIDP with tremor and poor response to intravenous immunoglobulins...

More Information

Publications100

  1. Suanprasert N, Taylor B, Klein C, Roforth M, Karam C, Keegan B, et al. Polyneuropathies and chronic inflammatory demyelinating polyradiculoneuropathy in multiple sclerosis. Mult Scler Relat Disord. 2019;30:284-290 pubmed publisher
    ..Serum from MS-CIDP for pan-IgG autoantibodies to neurofascin-155 were tested when available. From 1980-2013, 133 co-existing MS/ polyneuropathy cases were identified...
  2. Kira J, Yamasaki R, Ogata H. Anti-neurofascin autoantibody and demyelination. Neurochem Int. 2018;: pubmed publisher
    ..Thus, environmental antigens cross-reacting with nodal and paranodal proteins may warrant future study. ..
  3. Mohamed A, Krøigård T, Gaist T, Markvardsen L, Sindrup S, Andersen H, et al. [Antibodies in patients with chronic inflammatory demyelinating polyneuropathy]. Ugeskr Laeger. 2018;180: pubmed
    Recent studies have identified specific immunoglobulin (Ig) G4 antibodies against the paranodal proteins neurofascin 155 and contactin 1 in subgroups of patients with chronic inflammatory demyelinating polyneuropathy (CIDP)...
  4. McGonigal R, Barrie J, Yao D, McLaughlin M, Cunningham M, Rowan E, et al. Glial Sulfatides and Neuronal Complex Gangliosides Are Functionally Interdependent in Maintaining Myelinating Axon Integrity. J Neurosci. 2019;39:63-77 pubmed publisher
    ..These findings suggest that sulfatides and complex gangliosides on opposing axo-glial membranes are responsible for essential tethering of the axo-glial junction proteins NF155 and MAG, which interact to maintain the nodal complex. ..
  5. Koike H, Nishi R, Ikeda S, Kawagashira Y, Iijima M, Katsuno M, et al. Ultrastructural mechanisms of macrophage-induced demyelination in CIDP. Neurology. 2018;91:1051-1060 pubmed publisher
    ..In particular, immunoglobulin G4 (IgG4) antibodies to paranodal junction proteins, including neurofascin-155 and contactin-1, have attracted the attention of researchers...
  6. Arrambide G, Espejo C, Eixarch H, Villar L, Alvarez Cermeño J, Picón C, et al. Neurofilament light chain level is a weak risk factor for the development of MS. Neurology. 2016;87:1076-84 pubmed publisher
    ..We determined levels of neurofascin, semaphorin 3A, fetuin A, glial fibrillary acidic protein, and neurofilament light (NfL) and heavy chains in ..
  7. Saifetiarova J, Taylor A, Bhat M. Early and Late Loss of the Cytoskeletal Scaffolding Protein, Ankyrin G Reveals Its Role in Maturation and Maintenance of Nodes of Ranvier in Myelinated Axons. J Neurosci. 2017;37:2524-2538 pubmed publisher
    ..resulting in rapid voltage-gated sodium (NaV) channel and ?IV spectrin loss with reduced effects on neurofascin 186...
  8. Gennarini G, Bizzoca A, Picocci S, Puzzo D, Corsi P, Furley A. The role of Gpi-anchored axonal glycoproteins in neural development and neurological disorders. Mol Cell Neurosci. 2017;81:49-63 pubmed publisher
    ..paranodal regions, where CNTN1 interactions with Caspr1 and with the Ig superfamily component Neurofascin 155 in cis and in trans, respectively, build a molecular barrier between the node and the juxtaparanode...
  9. Chugh D, Ali I, Bakochi A, Bahonjic E, Etholm L, Ekdahl C. Alterations in Brain Inflammation, Synaptic Proteins, and Adult Hippocampal Neurogenesis during Epileptogenesis in Mice Lacking Synapsin2. PLoS ONE. 2015;10:e0132366 pubmed publisher
    ..Furthermore, we observed an increase in the inhibitory adhesion molecules neuroligin-2 and neurofascin and potassium chloride co-transporter KCC2...
  10. D Este E, Kamin D, Balzarotti F, Hell S. Ultrastructural anatomy of nodes of Ranvier in the peripheral nervous system as revealed by STED microscopy. Proc Natl Acad Sci U S A. 2017;114:E191-E199 pubmed publisher
    ..In contrast, axonal and glial nodal adhesion molecules [neurofascin-186, neuron glial-related cell adhesion molecule (NrCAM)] can arrange in a more complex, 2D hexagonal-like ..
  11. Williams M. The Drosophila cell adhesion molecule Neuroglian regulates Lissencephaly-1 localisation in circulating immunosurveillance cells. BMC Immunol. 2009;10:17 pubmed publisher
    ..In mammalian neuronal cells phosphorylated neurofascin, another L1-type cell adhesion molecule interacts with a nucleokinesis complex containing the microtubule ..
  12. Han H, Kursula P. Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the extracellular olfactomedin domain of gliomedin. Acta Crystallogr F Struct Biol Commun. 2014;70:1536-9 pubmed publisher
    ..in the accumulation of neuronal plasma membrane voltage-gated sodium channels in the nodes by interacting with neurofascin and NrCAM. No structures of OLF domains have previously been reported...
  13. Kadoya M, Kaida K, Koike H, Takazaki H, Ogata H, Moriguchi K, et al. IgG4 anti-neurofascin155 antibodies in chronic inflammatory demyelinating polyradiculoneuropathy: Clinical significance and diagnostic utility of a conventional assay. J Neuroimmunol. 2016;301:16-22 pubmed publisher
    ..aimed to validate the diagnostic utility of enzyme-linked immunosorbent assay (ELISA) for the detection of anti-neurofascin (NF) 155 antibody in 191 patients with chronic inflammatory demyelinating polyneuropathy (CIDP)...
  14. Saha R, Knapp S, Chakraborty D, Horovitz O, Albrecht A, Kriebel M, et al. GABAergic Synapses at the Axon Initial Segment of Basolateral Amygdala Projection Neurons Modulate Fear Extinction. Neuropsychopharmacology. 2017;42:473-484 pubmed publisher
    ..Here we used lentiviral-mediated knockdown of the cell adhesion molecule neurofascin in the basolateral amygdala (BLA) to specifically remove inhibitory synapses at the axon initial segment (AIS) ..
  15. Telley L, Cadilhac C, Cioni J, Saywell V, Jahannault Talignani C, Huettl R, et al. Dual Function of NRP1 in Axon Guidance and Subcellular Target Recognition in Cerebellum. Neuron. 2016;91:1276-1291 pubmed publisher
    ..Further, we identified NRP1 as a trans-synaptic binding partner of the cell adhesion molecule neurofascin-186 (NF186) expressed in the PC AIS during pinceau synapse formation...
  16. Gandomi N, Varshochian R, Atyabi F, Ghahremani M, Sharifzadeh M, Amini M, et al. Solid lipid nanoparticles surface modified with anti-Contactin-2 or anti-Neurofascin for brain-targeted delivery of medicines. Pharm Dev Technol. 2017;22:426-435 pubmed publisher
    ..In this study, PEGylated SLNs surface modified using anti-Contactin-2 or anti-Neurofascin, two axo-glial-glycoprotein antigens located in node of Ranvier, were prepared...
  17. Howell O, Rundle J, Garg A, Komada M, Brophy P, Reynolds R. Activated microglia mediate axoglial disruption that contributes to axonal injury in multiple sclerosis. J Neuropathol Exp Neurol. 2010;69:1017-1033 pubmed publisher
    ..The extent of paranodal axoglial (neurofascin-155(+)/Caspr1(+)) disruption correlated with local microglial inflammation and axonal injury (expression of ..
  18. Sinmaz N, Nguyen T, Tea F, Dale R, Brilot F. Mapping autoantigen epitopes: molecular insights into autoantibody-associated disorders of the nervous system. J Neuroinflammation. 2016;13:219 pubmed publisher
    ..GAD65), acetylcholine receptor (AChR), muscle-specific kinase (MuSK), voltage-gated calcium channel (VGCC), neurofascin (NF), and contactin...
  19. van Nierop G, Janssen M, Mitterreiter J, van de Vijver D, De Swart R, Haagmans B, et al. Intrathecal CD4(+) and CD8(+) T-cell responses to endogenously synthesized candidate disease-associated human autoantigens in multiple sclerosis patients. Eur J Immunol. 2016;46:347-53 pubmed publisher
    ..1, S100 calcium-binding protein B, contactin-2, and neurofascin. Transduced BLCLs were used as autologous APC in functional T-cell assays to determine cMSAg-specific T-cell ..
  20. Roche S, Sherman D, Dissanayake K, Soucy G, Desmazieres A, Lamont D, et al. Loss of glial neurofascin155 delays developmental synapse elimination at the neuromuscular junction. J Neurosci. 2014;34:12904-18 pubmed publisher
    ..synapse elimination at the mouse NMJ, where loss of a single glial cell protein, the glial isoform of neurofascin (Nfasc155), was sufficient to disrupt postnatal remodeling of synaptic circuitry...
  21. Zitman F, Lucas M, Trinks S, Grosse Ophoff L, Kriebel M, Volkmer H, et al. Dentate Gyrus Local Circuit is Implicated in Learning Under Stress--a Role for Neurofascin. Mol Neurobiol. 2016;53:842-50 pubmed publisher
    ..The cell adhesion molecule neurofascin is specifically expressed at the AIS. It is crucially required for the stabilization of axo-axonic synapses...
  22. Taylor A, Saifetiarova J, Bhat M. Postnatal Loss of Neuronal and Glial Neurofascins Differentially Affects Node of Ranvier Maintenance and Myelinated Axon Function. Front Cell Neurosci. 2017;11:11 pubmed publisher
    ..Previously, the cell surface adhesion molecule Neurofascin (Nfasc) has been shown to have a dual-role in the establishment of axonal domains from both the glial and ..
  23. Notturno F, Di Febo T, Yuki N, Fernandez Rodriguez B, Corti D, Nobile Orazio E, et al. Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy. J Neuroimmunol. 2014;276:207-12 pubmed publisher
    We tested autoantibodies to neurofascin-186 (NF186) and gliomedin in sera from patients with multifocal motor neuropathy (MMN, n=53) and chronic inflammatory demyelinating polyneuropathy (CIDP, n=95) by ELISA...
  24. Manso C, Querol L, Mekaouche M, Illa I, Devaux J. Contactin-1 IgG4 antibodies cause paranode dismantling and conduction defects. Brain. 2016;139:1700-12 pubmed publisher
    Paranodal axoglial junctions formed by the association of contactin-1, contactin-associated protein 1, and neurofascin-155, play important functions in nerve impulse propagation along myelinated axons...
  25. Mathey E, Garg N, Park S, Nguyen T, Baker S, Yuki N, et al. Autoantibody responses to nodal and paranodal antigens in chronic inflammatory neuropathies. J Neuroimmunol. 2017;309:41-46 pubmed publisher
    ..patients and to validate the presence anti-nodal antibodies in MMN, sera were screened for IgG against human neurofascin 155, contactin-1, neurofascin 186 and gliomedin using ELISA...
  26. Ferguson A, Lyall L, Ward J, Strawbridge R, Cullen B, Graham N, et al. Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood Instability. EBioMedicine. 2018;35:279-287 pubmed publisher
    ..Two independent genetic loci were associated with low RA, within genomic regions for Neurofascin (NFASC) and Solute Carrier Family 25 Member 17 (SLC25A17)...
  27. Hauser M, Yan R, Li W, Repina N, Schaffer D, Xu K. The Spectrin-Actin-Based Periodic Cytoskeleton as a Conserved Nanoscale Scaffold and Ruler of the Neural Stem Cell Lineage. Cell Rep. 2018;24:1512-1522 pubmed publisher
    ..between abutting cells at axon-axon and axon-oligodendrocyte contacts and identify two adhesion molecules, neurofascin and L1CAM, as candidates to drive this nanoscale alignment...
  28. Delmont E. Review of the literature: Articles published in the last five years that have changed my daily practice. Rev Neurol (Paris). 2016;172:785-787 pubmed publisher
    ..The structures of the nodes of Ranvier, gangliosides, contractin and neurofascin are preferential targets for auto-antibodies responsible for dysimmune neuropathies...
  29. Brügger V, Engler S, Pereira J, Ruff S, Horn M, Welzl H, et al. HDAC1/2-Dependent P0 Expression Maintains Paranodal and Nodal Integrity Independently of Myelin Stability through Interactions with Neurofascins. PLoS Biol. 2015;13:e1002258 pubmed publisher
    ..target gene myelin protein zero (P0) were reduced by half, accompanied by altered localization and stability of neurofascin (NFasc)155, NFasc186, and loss of Caspr and septate-like junctions...
  30. Reimer M, McQueen J, Searcy L, Scullion G, Zonta B, Desmazieres A, et al. Rapid disruption of axon-glial integrity in response to mild cerebral hypoperfusion. J Neurosci. 2011;31:18185-94 pubmed publisher
    ..This was marked by a progressive reduction of paranodal Neurofascin signal and a loss of septate-like junctions...
  31. Stich O, Perera S, Berger B, Jarius S, Wildemann B, Baumgartner A, et al. Prevalence of neurofascin-155 antibodies in patients with multiple sclerosis. J Neurol Sci. 2016;364:29-32 pubmed publisher
    Antibodies against neurofascin, an axo-glial protein located around the node of Ranvier, have been shown to contribute to axonal pathology both in vitro and in experimental autoimmune encephalomyelitis models...
  32. Saha R, Kriebel M, Volkmer H, Richter Levin G, Albrecht A. Neurofascin Knock Down in the Basolateral Amygdala Mediates Resilience of Memory and Plasticity in the Dorsal Dentate Gyrus Under Stress. Mol Neurobiol. 2018;55:7317-7326 pubmed publisher
    ..Here, we have utilized lentiviral knock down of neurofascin to reduce GABAergic inhibition specifically at the axon initial segment (AIS) of principal neurons within the ..
  33. Dumitrescu A, Evans M, Grubb M. Evaluating Tools for Live Imaging of Structural Plasticity at the Axon Initial Segment. Front Cell Neurosci. 2016;10:268 pubmed
    ..We found that an antibody targeting the extracellular domain of neurofascin provided accurate live label of AIS structure at baseline, but could not follow rapid activity-dependent ..
  34. Doppler K, Appeltshauser L, Villmann C, Martin C, Peles E, Krämer H, et al. Auto-antibodies to contactin-associated protein 1 (Caspr) in two patients with painful inflammatory neuropathy. Brain. 2016;139:2617-2630 pubmed
    Auto-antibodies against the paranodal proteins neurofascin-155 and contactin-1 have recently been described in patients with chronic inflammatory demyelinating polyradiculoneuropathy and are associated with a distinct clinical phenotype ..
  35. Yan W, Nguyen T, Yuki N, Ji Q, Yiannikas C, Pollard J, et al. Antibodies to neurofascin exacerbate adoptive transfer experimental autoimmune neuritis. J Neuroimmunol. 2014;277:13-7 pubmed publisher
    ..Here we screened patient sera for autoantibodies to neurofascin and assessed the pathophysiological relevance of anti-neurofascin antibodies in vivo...
  36. Leterrier C, Clerc N, Rueda Boroni F, Montersino A, Dargent B, Castets F. Ankyrin G Membrane Partners Drive the Establishment and Maintenance of the Axon Initial Segment. Front Cell Neurosci. 2017;11:6 pubmed publisher
    ..we found that shRNA-mediated knockdown of ankG membrane partners (voltage-gated sodium channels (Nav) or neurofascin-186) led to a decrease of ankG concentration and perturbed the AIS formation and maintenance...
  37. Flytzani S, Guerreiro Cacais A, N diaye M, Lindner M, Linington C, Meinl E, et al. MOG-induced experimental autoimmune encephalomyelitis in the rat species triggers anti-neurofascin antibody response that is genetically regulated. J Neuroinflammation. 2015;12:194 pubmed publisher
    ..Using different EAE models, we investigated the pathophysiological basis of epitope spreading to neurofascin, a protein localized at the node of Ranvier and its regulation by non-MHC genes...
  38. Doppler K, Stengel H, Appeltshauser L, Grosskreutz J, Man Ng J, Meinl E, et al. Neurofascin-155 IgM autoantibodies in patients with inflammatory neuropathies. J Neurol Neurosurg Psychiatry. 2018;89:1145-1151 pubmed publisher
    ..we screened a large cohort of patients (n=140) with inflammatory neuropathies for IgM autoantibodies against neurofascin-155, neurofascin-186 or contactin-1...
  39. Han H, Kursula P. The olfactomedin domain from gliomedin is a β-propeller with unique structural properties. J Biol Chem. 2015;290:3612-21 pubmed publisher
    ..Gliomedin interacts with neuronal cell adhesion molecules, such as neurofascin, but the structural details of the interaction are not known...
  40. Zhang A, Desmazieres A, Zonta B, Melrose S, Campbell G, Mahad D, et al. Neurofascin 140 is an embryonic neuronal neurofascin isoform that promotes the assembly of the node of Ranvier. J Neurosci. 2015;35:2246-54 pubmed publisher
    ..The Neurofascin (Nfasc) gene has a unique role in node formation because it encodes glial and neuronal isoforms of neurofascin (..
  41. Vallat J, Yuki N, Sekiguchi K, Kokubun N, Oka N, Mathis S, et al. Paranodal lesions in chronic inflammatory demyelinating polyneuropathy associated with anti-Neurofascin 155 antibodies. Neuromuscul Disord. 2017;27:290-293 pubmed publisher
    Antibodies to Contactin-1 and Neurofascin 155 (Nfasc155) have recently been associated with subsets of patients with chronic inflammatory demyelinating polyneuropathy (CIDP)...
  42. Koike H, Kadoya M, Kaida K, Ikeda S, Kawagashira Y, Iijima M, et al. Paranodal dissection in chronic inflammatory demyelinating polyneuropathy with anti-neurofascin-155 and anti-contactin-1 antibodies. J Neurol Neurosurg Psychiatry. 2017;88:465-473 pubmed publisher
    ..We assessed sural nerve biopsy specimens obtained from 9 patients with CIDP with anti-neurofascin-155 antibodies and 1 patient with anti-contactin-1 antibodies...
  43. Maluenda J, Manso C, Quevarec L, Vivanti A, Marguet F, Gonzales M, et al. Mutations in GLDN, Encoding Gliomedin, a Critical Component of the Nodes of Ranvier, Are Responsible for Lethal Arthrogryposis. Am J Hum Genet. 2016;99:928-933 pubmed publisher
    ..individuals abolish the cell surface localization of gliomedin and its interaction with its axonal partner, neurofascin-186 (NF186), in a cell-based assay...
  44. Chang K, Zollinger D, Susuki K, Sherman D, Makara M, Brophy P, et al. Glial ankyrins facilitate paranodal axoglial junction assembly. Nat Neurosci. 2014;17:1673-81 pubmed publisher
    ..at the glial side of paranodal junctions where they interact with the essential glial junctional component neurofascin 155...
  45. Devaux J. [New insights on the organization of the nodes of Ranvier]. Rev Neurol (Paris). 2014;170:819-24 pubmed publisher
    ..nodes implicates adhesion molecules expressed by the Schwann cell (gliomedin and NrCAM), which binds a partner, neurofascin-186, on the axonal side...
  46. Darbelli L, Vogel G, Almazan G, Richard S. Quaking Regulates Neurofascin 155 Expression for Myelin and Axoglial Junction Maintenance. J Neurosci. 2016;36:4106-20 pubmed publisher
    ..Moreover, deterioration of axoglial junctions of the spinal cord was observed and is consistent with a loss of Neurofascin 155 (Nfasc155) isoform that we confirmed as an alternative splice target of the QKI proteins...
  47. Yang W, Wang G, Wang C, Guo X, Yin P, Gao J, et al. Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain. J Neurosci. 2015;35:8345-58 pubmed publisher
    ..Using monkey brain tissues, we found that A53T interacts with neurofascin, an adhesion molecule involved in axon subcellular targeting and neurite outgrowth...
  48. Martinez Martinez L, Lleixà M, Boera Carnicero G, Cortese A, Devaux J, Siles A, et al. Anti-NF155 chronic inflammatory demyelinating polyradiculoneuropathy strongly associates to HLA-DRB15. J Neuroinflammation. 2017;14:224 pubmed publisher
    ..II allele frequencies in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) associated with anti-neurofascin 155 (NF155) antibodies...
  49. Ango F, Di Cristo G, Higashiyama H, Bennett V, Wu P, Huang Z. Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment. Cell. 2004;119:257-72 pubmed
    ..In the absence of neurofascin gradient, basket axons lost directional growth along Purkinje neurons and precisely followed NF186 to ectopic ..
  50. Querol L, Siles A, Alba Rovira R, Jáuregui A, Devaux J, Faivre Sarrailh C, et al. Antibodies against peripheral nerve antigens in chronic inflammatory demyelinating polyradiculoneuropathy. Sci Rep. 2017;7:14411 pubmed publisher
    ..Three patients (4.6%) had antibodies against neurofascin 155, four (6.2%) against contactin-1 and one (1...
  51. Fehmi J, Scherer S, Willison H, Rinaldi S. Nodes, paranodes and neuropathies. J Neurol Neurosurg Psychiatry. 2018;89:61-71 pubmed publisher
    ..It is now apparent that antibodies directed against several region-specific cell adhesion molecules, including neurofascin, contactin and contactin-associated protein, can be linked to phenotypically distinct peripheral neuropathies...
  52. Ren Q, Bennett V. Palmitoylation of neurofascin at a site in the membrane-spanning domain highly conserved among the L1 family of cell adhesion molecules. J Neurochem. 1998;70:1839-49 pubmed
    ..b>Neurofascin is constitutively palmitoylated at cysteine-1213 at close to a 1:1 molar stoichiometry...
  53. Thaxton C, Pillai A, Pribisko A, Labasque M, Dupree J, Faivre Sarrailh C, et al. In vivo deletion of immunoglobulin domains 5 and 6 in neurofascin (Nfasc) reveals domain-specific requirements in myelinated axons. J Neurosci. 2010;30:4868-76 pubmed publisher
    ..encoding the critical paranodal proteins Caspr, contactin (Cont), and the myelinating glia-specific isoform of Neurofascin (Nfasc(NF155)) results in the disruption of the paranodal axo-glial junctions, loss of ion channel segregation, ..
  54. Jenkins S, Kizhatil K, Kramarcy N, Sen A, Sealock R, Bennett V. FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons. J Cell Sci. 2001;114:3823-35 pubmed
    Phosphorylation of neurofascin, a member of the L1 family of cell adhesion molecules (L1 CAMs), at the conserved FIGQY-tyrosine abolishes the ankyrin-neurofascin interaction...
  55. Anazi S, Maddirevula S, Salpietro V, Asi Y, Alsahli S, Alhashem A, et al. Expanding the genetic heterogeneity of intellectual disability. Hum Genet. 2017;136:1419-1429 pubmed publisher
    ..Our study expands the locus and allelic heterogeneity of ID and demonstrates the power of positional mapping to reveal unusual mutational mechanisms. ..
  56. Homma K, Kikuno R, Nagase T, Ohara O, Nishikawa K. Alternative splice variants encoding unstable protein domains exist in the human brain. J Mol Biol. 2004;343:1207-20 pubmed
    ..We propose that most unstable proteins encoded by alternative splice variants lack normal functions and are an evolutionary dead-end. ..
  57. Jenkins S, Bennett V. Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments. J Cell Biol. 2001;155:739-46 pubmed
    ..6, betaIV spectrin, and the L1 cell adhesion molecules (L1 CAMs) neurofascin and NrCAM at initial segments of cerebellar Purkinje neurons...
  58. Liu Z, Guo X, Jiang Y, Zhang H. NCK2 is significantly associated with opiates addiction in African-origin men. ScientificWorldJournal. 2013;2013:748979 pubmed publisher
    ..In summary, our findings provided the first evidence for the involvement of NCK2 in the susceptibility to opiates addiction and further revealed the racial and gender specificities of its impact. ..
  59. Koroll M, Rathjen F, Volkmer H. The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity. J Biol Chem. 2001;276:10646-54 pubmed
    b>Neurofascin belongs to the L1 subgroup of the immunoglobulin superfamily of cell adhesion molecules and is implicated in axonal growth and fasciculation...
  60. Liu H, Focia P, He X. Homophilic adhesion mechanism of neurofascin, a member of the L1 family of neural cell adhesion molecules. J Biol Chem. 2011;286:797-805 pubmed publisher
    ..We report two crystal structures of a dimeric form of the headpiece of neurofascin, an L1 family member...
  61. Kriebel M, Wuchter J, Trinks S, Volkmer H. Neurofascin: a switch between neuronal plasticity and stability. Int J Biochem Cell Biol. 2012;44:694-7 pubmed publisher
    b>Neurofascin (NF) is a cell surface protein belonging to the immunoglobulin superfamily (IgSF). Different polypeptides of 186, 180, 166 and 155 kDa are generated by alternative splicing...
  62. Burnor E, Yang L, Zhou H, Patterson K, Quinn C, Reilly M, et al. Neurofascin antibodies in autoimmune, genetic, and idiopathic neuropathies. Neurology. 2018;90:e31-e38 pubmed publisher
    To measure the frequency, persistence, isoform specificity, and clinical correlates of neurofascin antibodies in patients with peripheral neuropathies...
  63. Fujita A, Ogata H, Yamasaki R, Matsushita T, Kira J. Parallel fluctuation of anti-neurofascin 155 antibody levels with clinico-electrophysiological findings in patients with chronic inflammatory demyelinating polyradiculoneuropathy. J Neurol Sci. 2018;384:107-112 pubmed publisher
    ..and closely related biomarkers in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) with anti-neurofascin 155 (NF155) antibodies remain to be elucidated...
  64. Suzuki S, Ayukawa N, Okada C, Tanaka M, Takekoshi S, Iijima Y, et al. Spatio-temporal and dynamic regulation of neurofascin alternative splicing in mouse cerebellar neurons. Sci Rep. 2017;7:11405 pubmed publisher
    ..b>Neurofascin (NF) is a polymorphic cell surface protein that has a number of splicing isoforms...
  65. Hoshino M, Suzuki Y, Akiyama H, Yamada K, Shima S, Mutoh T, et al. [Efficacy of high-dose steroid pulse therapy for anti-galactocerebroside antibody-positive combined central and peripheral demyelination]. Rinsho Shinkeigaku. 2017;: pubmed publisher
    ..The level of myelin basic protein was high (1,260?pg/ml) in the cerebrospinal fluid and serum anti-neurofascin antibody was negative. Nerve conduction study showed typical findings of demyelination at least 2 regions...
  66. Saha R, Shrivastava K, Jing L, Schayek R, Maroun M, Kriebel M, et al. Perturbation of GABAergic Synapses at the Axon Initial Segment of Basolateral Amygdala Induces Trans-regional Metaplasticity at the Medial Prefrontal Cortex. Cereb Cortex. 2018;28:395-410 pubmed publisher
    ..GABAergic synapses innervating specifically at the axon initial segment (AIS) of principal neurons of BLA, by neurofascin (NF) knockdown, impairs fear extinction...
  67. Maier O, Baron W, Hoekstra D. Reduced raft-association of NF155 in active MS-lesions is accompanied by the disruption of the paranodal junction. Glia. 2007;55:885-95 pubmed
  68. Samulin Erdem J, Arnoldussen Y, Skaug V, Haugen A, Zienolddiny S. Copy number variation, increased gene expression, and molecular mechanisms of neurofascin in lung cancer. Mol Carcinog. 2017;56:2076-2085 pubmed publisher
    Metastasis and cell adhesion are key aspects of cancer progression. Neurofascin (NFASC) is a member of the immunoglobulin superfamily of adhesion molecules and, while studies on NFASC are inadequate, other members have been indicated ..
  69. Koticha D, Babiarz J, Kane Goldsmith N, Jacob J, Raju K, Grumet M. Cell adhesion and neurite outgrowth are promoted by neurofascin NF155 and inhibited by NF186. Mol Cell Neurosci. 2005;30:137-48 pubmed
    b>Neurofascin (NF) is a neural cell adhesion molecule in the L1-family containing six Ig domains and multiple fibronectin type III (FnIII) repeats in its extracellular region...
  70. Kizhatil K, Wu Y, Sen A, Bennett V. A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domain of neurofascin. J Neurosci. 2002;22:7948-58 pubmed
    ..of the FIGQY-phosphotyrosine motif present in the cytoplasmic domain of the L1 cell adhesion molecule neurofascin. Phospho-FIGQY-neurofascin (186 kDa) coimmunoprecipitated with doublecortin from detergent extracts of ..
  71. Kawamura N. [Neurofascin: a novel target for combined central and peripheral demyelination]. Rinsho Shinkeigaku. 2014;54:978-80 pubmed publisher
    ..We identified anti-neurofascin antibody in the serum from these CCPD patients...
  72. Buttermore E, Piochon C, Wallace M, Philpot B, Hansel C, Bhat M. Pinceau organization in the cerebellum requires distinct functions of neurofascin in Purkinje and basket neurons during postnatal development. J Neurosci. 2012;32:4724-42 pubmed publisher
    ..Loss of cytoskeletal adaptor protein Ankyrin G (AnkG) results in mislocalization of the cell adhesion molecule Neurofascin (Nfasc) at the Purkinje AIS and abnormal organization of the pinceau...
  73. Kwon H, Johnson T, Joe M, Abu Asab M, Zhang J, Chan C, et al. Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling. J Biol Chem. 2013;288:26357-71 pubmed publisher
    ..There, myocilin interacts with gliomedin, neurofascin, and NrCAM, which are essential for node formation and function...
  74. Kirschbaum K, Kriebel M, Kranz E, Pötz O, Volkmer H. Analysis of non-canonical fibroblast growth factor receptor 1 (FGFR1) interaction reveals regulatory and activating domains of neurofascin. J Biol Chem. 2009;284:28533-42 pubmed publisher
    ..Here, we show a new link between FGFR1 and the cell adhesion molecule neurofascin, which is important for neurite outgrowth...
  75. Sistani L, Rodriguez P, Hultenby K, Uhlen M, Betsholtz C, Jalanko H, et al. Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation. Kidney Int. 2013;83:63-71 pubmed publisher
    ..Unexpectedly, the survey found expression of three neuronal proteins (Huntingtin interacting protein 1 (Hip1), neurofascin (Nfasc), and olfactomedin-like 2a (Olfml2a)), all enriched in the glomerulus...
  76. Palavicini J, Wang C, Chen L, Ahmar S, Higuera J, Dupree J, et al. Novel molecular insights into the critical role of sulfatide in myelin maintenance/function. J Neurochem. 2016;139:40-54 pubmed publisher
    ..depletion leads to region-specific effects on non-compact myelin, dramatically affecting the paranode (neurofascin 155) and the major inner tongue myelin protein (myelin-associated glycoprotein)...
  77. Tuvia S, Garver T, Bennett V. The phosphorylation state of the FIGQY tyrosine of neurofascin determines ankyrin-binding activity and patterns of cell segregation. Proc Natl Acad Sci U S A. 1997;94:12957-62 pubmed
    ..This study provides evidence for regulation of cell interactions through modulation of ankyrin binding to neurofascin, a member of the L1CAM family of nervous system cell adhesion molecules...
  78. Devaux J, Miura Y, Fukami Y, Inoue T, Manso C, Belghazi M, et al. Neurofascin-155 IgG4 in chronic inflammatory demyelinating polyneuropathy. Neurology. 2016;86:800-7 pubmed publisher
    ..features of Japanese patients with chronic inflammatory demyelinating polyneuropathy (CIDP) displaying anti-neurofascin-155 (NF155) immunoglobulin G4 (IgG4) antibodies...
  79. Burmeister M, Ren Q, Makris G, Samson D, Bennett V. Genes for the neuronal immunoglobulin domain cell adhesion molecules neurofascin and Nr-CAM map to mouse chromosomes 1 and 12 and homologous human chromosomes. Mamm Genome. 1996;7:558-9 pubmed
  80. Kawamura N, Yamasaki R, Yonekawa T, Matsushita T, Kusunoki S, Nagayama S, et al. Anti-neurofascin antibody in patients with combined central and peripheral demyelination. Neurology. 2013;81:714-22 pubmed publisher
    ..showed cross-like binding to sciatic nerve sections at fixed intervals, with nearly perfect colocalization with neurofascin immunostaining at the node and paranode...
  81. Schafer D, Custer A, Shrager P, Rasband M. Early events in node of Ranvier formation during myelination and remyelination in the PNS. Neuron Glia Biol. 2006;2:69-79 pubmed
    ..6 is detected at new nodes. Finally, we show that accumulation of the cell adhesion molecule neurofascin always precedes Nav channel clustering in the PNS...
  82. Garg N, Park S, Yiannikas C, Vucic S, Howells J, Noto Y, et al. Neurofascin-155 IgG4 Neuropathy: Pathophysiological insights, spectrum of clinical severity and response to treatment. Muscle Nerve. 2017;: pubmed publisher
    Sensorimotor neuropathy associated with IgG4 antibodies to neurofascin-155 (NF155) was recently described. The clinical phenotype is typically associated with young onset, distal weakness and in some cases, tremor.
  83. Darbelli L, Choquet K, Richard S, Kleinman C. Transcriptome profiling of mouse brains with qkI-deficient oligodendrocytes reveals major alternative splicing defects including self-splicing. Sci Rep. 2017;7:7554 pubmed publisher
    ..These findings define QKI as regulators of alternative splicing in OLs including self-splicing. ..
  84. Delmont E, Manso C, Querol L, Cortese A, Berardinelli A, Lozza A, et al. Autoantibodies to nodal isoforms of neurofascin in chronic inflammatory demyelinating polyneuropathy. Brain. 2017;140:1851-1858 pubmed publisher
    ..Recent evidence indicates that paranodal proteins (contactin 1, contactin-associated protein 1, and neurofascin-155) are the targets of autoantibodies in subsets of patients showing distinct clinical presentations...
  85. Querol L, Nogales Gadea G, Rojas García R, Diaz Manera J, Pardo J, Ortega Moreno A, et al. Neurofascin IgG4 antibodies in CIDP associate with disabling tremor and poor response to IVIg. Neurology. 2014;82:879-86 pubmed publisher
    To describe the frequency of antibodies against neurofascin in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and the associated clinical features...
  86. Mathey E, Derfuss T, Storch M, Williams K, Hales K, Woolley D, et al. Neurofascin as a novel target for autoantibody-mediated axonal injury. J Exp Med. 2007;204:2363-72 pubmed
    ..Starting with a proteomics-based approach, we identified neurofascin-specific autoantibodies in patients with MS...
  87. Pomicter A, Shroff S, Fuss B, Sato Bigbee C, Brophy P, Rasband M, et al. Novel forms of neurofascin 155 in the central nervous system: alterations in paranodal disruption models and multiple sclerosis. Brain. 2010;133:389-405 pubmed publisher
    ..comprised of the neuronal heterocomplex of contactin and contactin-associated protein and the myelin protein neurofascin 155...
  88. Devaux J. Antibodies to gliomedin cause peripheral demyelinating neuropathy and the dismantling of the nodes of Ranvier. Am J Pathol. 2012;181:1402-13 pubmed publisher
    ..In particular, GBS patients have antibodies against gliomedin and neurofascin, two adhesion molecules that play a crucial role in the formation of nodes of Ranvier...
  89. Liu M, Xu P, Guan Z, Qian X, Dockery P, FitzGerald U, et al. Ulk4 deficiency leads to hypomyelination in mice. Glia. 2018;66:175-190 pubmed publisher
    ..This is the first evidence demonstrating that ULK4 is a crucial regulator of myelination, and ULK4 may therefore become a novel therapeutic target for hypomyelination diseases. ..
  90. Labasque M, Devaux J, Leveque C, Faivre Sarrailh C. Fibronectin type III-like domains of neurofascin-186 protein mediate gliomedin binding and its clustering at the developing nodes of Ranvier. J Biol Chem. 2011;286:42426-34 pubmed publisher
    ..nervous system, Gliomedin (Gldn) secreted by Schwann cell microvilli binds NgCAM-related CAM (NrCAM) and Neurofascin-186 (NF186) and direct the nodal clustering of voltage-gated sodium channels (Nav)...
  91. Devaux J, Odaka M, Yuki N. Nodal proteins are target antigens in Guillain-Barré syndrome. J Peripher Nerv Syst. 2012;17:62-71 pubmed publisher
    b>Neurofascin-186 (NF186), neuronal cell adhesion molecule (NrCAM), and gliomedin are adhesion molecules playing a central role in the formation of nodes of Ranvier...