NEU1

Summary

Gene Symbol: NEU1
Description: neuraminidase 1
Alias: NANH, NEU, SIAL1, sialidase-1, G9 sialidase, N-acetyl-alpha-neuraminidase 1, acetylneuraminyl hydrolase, exo-alpha-sialidase, lysosomal sialidase, sialidase 1 (lysosomal sialidase)
Species: human
Products:     NEU1

Top Publications

  1. Bonten E, Van der Spoel A, Fornerod M, Grosveld G, d Azzo A. Characterization of human lysosomal neuraminidase defines the molecular basis of the metabolic storage disorder sialidosis. Genes Dev. 1996;10:3156-69 pubmed
    ..These results establish the molecular basis of sialidosis in these patients, and clearly identify the cDNA-encoded protein as lysosomal neuraminidase. ..
  2. Naganawa Y, Itoh K, Shimmoto M, Takiguchi K, Doi H, Nishizawa Y, et al. Molecular and structural studies of Japanese patients with sialidosis type 1. J Hum Genet. 2000;45:241-9 pubmed
    ..Considering the data, we surmise that the V217M substitution may be closely associated with the phenotype of sialidosis type 1 with a late onset and moderate clinical course. ..
  3. Pattison S, Pankarican M, Rupar C, Graham F, Igdoura S. Five novel mutations in the lysosomal sialidase gene (NEU1) in type II sialidosis patients and assessment of their impact on enzyme activity and intracellular targeting using adenovirus-mediated expression. Hum Mutat. 2004;23:32-9 pubmed
    Sialidosis is an autosomal recessive disease resulting from a deficiency of lysosomal sialidase. Type II sialidosis is a rare disease characterized clinically by hydrops fetalis, hepatosplenomegaly, and severe psychomotor retardation...
  4. Van der Spoel A, Bonten E, d Azzo A. Transport of human lysosomal neuraminidase to mature lysosomes requires protective protein/cathepsin A. EMBO J. 1998;17:1588-97 pubmed
    ..These data suggest a novel role for PPCA in the activation of lysosomal neuraminidase, that of an intracellular transport protein. ..
  5. Bonten E, Arts W, Beck M, Covanis A, Donati M, Parini R, et al. Novel mutations in lysosomal neuraminidase identify functional domains and determine clinical severity in sialidosis. Hum Mol Genet. 2000;9:2715-25 pubmed
    ..Overall, our findings explain the clinical heterogeneity observed in sialidosis and may help in the assignment of existing or new allelic combinations to specific phenotypes. ..
  6. Lukong K, Landry K, Elsliger M, Chang Y, Lefrancois S, Morales C, et al. Mutations in sialidosis impair sialidase binding to the lysosomal multienzyme complex. J Biol Chem. 2001;276:17286-90 pubmed
    Sialidosis is an autosomal recessive disease caused by the genetic deficiency of lysosomal sialidase, which catalyzes the catabolism of sialoglycoconjugates...
  7. Seyrantepe V, Poupetova H, Froissart R, Zabot M, Maire I, Pshezhetsky A. Molecular pathology of NEU1 gene in sialidosis. Hum Mutat. 2003;22:343-52 pubmed
    b>Lysosomal sialidase (EC 3.2.1.18) has a dual physiological function; it participates in intralysosomal catabolism of sialylated glycoconjugates and is involved in cellular immune response...
  8. Bonten E, Campos Y, Zaitsev V, Nourse A, Waddell B, Lewis W, et al. Heterodimerization of the sialidase NEU1 with the chaperone protective protein/cathepsin A prevents its premature oligomerization. J Biol Chem. 2009;284:28430-41 pubmed publisher
    Lysosomal neuraminidase-1 (NEU1) forms a multienzyme complex with beta-galactosidase and protective protein/cathepsin A (PPCA)...
  9. Wu J, Zhu Y, Hu Y. Mechanism of feedback regulation of neutrophil inflammation in Henoch-Schönlein purpura. Eur Rev Med Pharmacol Sci. 2016;20:4277-4285 pubmed
    ..blood levels of white blood cells (WBC), mean corpuscular hemoglobin concentration (MCHC), neutrophils (NEU) and NEU% were significantly increased, whereas levels of red blood cells (RBC), hemoglobin (HGB), eosinophils (EOS)..

More Information

Publications146 found, 100 shown here

  1. Schene I, Kalinina Ayuso V, de Sain van der Velden M, van Gassen K, Cuppen I, van Hasselt P, et al. Pitfalls in Diagnosing Neuraminidase Deficiency: Psychosomatics and Normal Sialic Acid Excretion. JIMD Rep. 2016;25:9-13 pubmed
    ..Urinary-bound sialic acid levels were normal. Sequencing of NEU1 demonstrated two known compound heterozygous mutations (c.1195_1200dup p.His399_Tyr400dup; c.679G>A, p...
  2. Lagzian M, Bassami M, Dehghani H. In vitro responses of chicken macrophage-like monocytes following exposure to pathogenic and non-pathogenic E. coli ghosts loaded with a rational design of conserved genetic materials of influenza and Newcastle disease viruses. Vet Immunol Immunopathol. 2016;176:5-17 pubmed publisher
    ..coli (APEC). ..
  3. Wei Y, Luo Q, Sun J, Chen M, Liu F, Dong J. Bu-Shen-Yi-Qi formulae suppress chronic airway inflammation and regulate Th17/Treg imbalance in the murine ovalbumin asthma model. J Ethnopharmacol. 2015;164:368-77 pubmed publisher
    ..05), resulted in a dramatic reduction in total inflammatory cells as well as neutrophils (Neu), lymphocytes (Lym), monocytes (Mon), eosinophils (Eos) and basophils (Bas) of OVA-induced asthmatic mice (p<0...
  4. Zheng F, Wang D, Liu N, Shao X, Jin X. [Analysis of evaluation indexes for prognosis of severe burn patients with sepsis]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017;29:327-331 pubmed publisher
    ..no significant difference in body temperature, heart rate, white blood cell count (WBC), percentage of neutrophils (Neu), Na+, Glu, CRP, PCT, PaCO2 at the time of admission and diagnosis of sepsis and PLT at the ..
  5. Bitzan M, Alkandari O, Whittemore B, Yin X. Complement depletion and Coombs positivity in pneumococcal hemolytic uremic syndrome (pnHUS). Case series and plea to revisit an old pathogenetic concept. Int J Med Microbiol. 2018;308:1096-1104 pubmed publisher
  6. Reid S, Brookes S, Nunez A, Banks J, Parker C, Ceeraz V, et al. Detection of non-notifiable H4N6 avian influenza virus in poultry in Great Britain. Vet Microbiol. 2018;224:107-115 pubmed publisher
    ..No other cases were reported. Infection with LPAIVs often result in variable clinical presentation in poultry, making detection of disease more difficult. ..
  7. Khurana S, Chung K, Coyle E, Meijer A, Golding H. Antigenic Fingerprinting of Antibody Response in Humans following Exposure to Highly Pathogenic H7N7 Avian Influenza Virus: Evidence for Anti-PA-X Antibodies. J Virol. 2016;90:9383-93 pubmed publisher
  8. Kautto L, Nguyen Khuong T, Everest Dass A, Leong A, Zhao Z, Willcox M, et al. Glycan involvement in the adhesion of Pseudomonas aeruginosa to tears. Exp Eye Res. 2016;145:278-288 pubmed publisher
    ..The work may contribute towards the development of glycan-focused therapies to prevent P. aeruginosa infection of the eye. ..
  9. Swayne D, Suarez D, Spackman E, Jadhao S, Dauphin G, Kim Torchetti M, et al. Antibody titer has positive predictive value for vaccine protection against challenge with natural antigenic-drift variants of H5N1 high-pathogenicity avian influenza viruses from Indonesia. J Virol. 2015;89:3746-62 pubmed publisher
    ..These studies indicate the need for surveillance to identify drift variant viruses in the field and update licensed vaccines when such variants appear. ..
  10. Wei W, Jones R, Juhasz C, Gibson H, Veenstra J. Evolution of animal models in cancer vaccine development. Vaccine. 2015;33:7401-7407 pubmed publisher
    ..Mimicking immune tolerance to tumor-associated antigens (TAA) such as HER2/neu, transgenic mice developing spontaneous mammary tumors are strong model systems for pre-clinical vaccine testing...
  11. Martinez Fierro M, Castruita De la Rosa C, Garza Veloz I, Cardiel Hernandez R, Espinoza Juarez M, Delgado Enciso I, et al. Early pregnancy protein multiplex screening reflects circulating and urinary divergences associated with the development of preeclampsia. Hypertens Pregnancy. 2018;37:37-50 pubmed publisher
    ..8 times in the study population. The proteins sEGFR, HGF, ANG-2, sFASL, IL-6, PLGF, VEGF-A, PRL, TGF-? FGF-b, sHER2/Neu sIL-6R?, ENG, uPA, and insulin-like growth factor binding protein 1 (IGFBP-1), were predictive of the development ..
  12. Suzuki O, Abe M, Hashimoto Y. Sialylation and glycosylation modulate cell adhesion and invasion to extracellular matrix in human malignant lymphoma: Dependency on integrin and the Rho GTPase family. Int J Oncol. 2015;47:2091-9 pubmed publisher
    ..These findings will provide new insight into the glycobiology of human malignant lymphoma. ..
  13. Ecker B, Lee J, Sterner C, Solomon A, Pant D, Shen F, et al. Impact of obesity on breast cancer recurrence and minimal residual disease. Breast Cancer Res. 2019;21:41 pubmed publisher
    ..Doxycycline-inducible primary mammary tumors were generated in intact MMTV-rtTA;TetO-HER2/neu (MTB/TAN) mice or orthotopic recipients fed a high-fat diet (HFD; 60% kcal from fat) or a control low-fat diet (LFD;..
  14. Markmann S, Krambeck S, Hughes C, Mirzaian M, Aerts J, Saftig P, et al. Quantitative Proteome Analysis of Mouse Liver Lysosomes Provides Evidence for Mannose 6-phosphate-independent Targeting Mechanisms of Acid Hydrolases in Mucolipidosis II. Mol Cell Proteomics. 2017;16:438-450 pubmed publisher
    ..Hypersecretion of newly synthesized nonphosphorylated lysosomal proteins suggest that secretion-recapture mechanisms contribute to maintain major lysosomal functions in liver. ..
  15. Hasskarl J. Everolimus. Recent Results Cancer Res. 2018;211:101-123 pubmed publisher
    ..The EMA has approved Everolimus as Afinitor® for the treatment of hormone receptor-positive, HER2/neu-negative advanced breast cancer, in combination with exemestane, in postmenopausal women without symptomatic ..
  16. Chen J, Pan W, D Souza M, August J. Lysosome-associated membrane proteins: characterization of LAMP-1 of macrophage P388 and mouse embryo 3T3 cultured cells. Arch Biochem Biophys. 1985;239:574-86 pubmed
    ..beta-D-Xyloside inhibition of glycosaminoglycan synthesis had little effect on the apparent mass of LAMP-1. ..
  17. Finlay T, Jayanth P, Amith S, Gilmour A, Guzzo C, Gee K, et al. Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9. Glycoconj J. 2010;27:329-48 pubmed publisher
    ..1 microM for neuraminidase inhibitor DANA (2-deoxy-2,3-dehydro-N-acetylneuraminic acid). Anti-Neu1, -2 and -3 antibodies have no inhibition of TQ-induced sialidase activity in live BMC-2 and human THP-1 macrophage ..
  18. De Clercq E, Li G. Approved Antiviral Drugs over the Past 50 Years. Clin Microbiol Rev. 2016;29:695-747 pubmed publisher
  19. Zhi H, Zhu H, Zhang Y, Lu Y, Li H, Chen D. In vivo effect of quantified flavonoids-enriched extract of Scutellaria baicalensis root on acute lung injury induced by influenza A virus. Phytomedicine. 2018;57:105-116 pubmed publisher
    ..Furthermore, FESR resulted in more potent therapeutic effect than BG in the treatment of IAV-induced ALI. ..
  20. Yassin A, Langenberg S, Huntemann M, Clum A, Pillay M, Palaniappan K, et al. Draft genome sequence of Actinotignum schaalii DSM 15541T: Genetic insights into the lifestyle, cell fitness and virulence. PLoS ONE. 2017;12:e0188914 pubmed publisher
  21. López Posadas R, Gonzalez R, Ballester I, Martínez Moya P, Romero Calvo I, Suárez M, et al. Tissue-nonspecific alkaline phosphatase is activated in enterocytes by oxidative stress via changes in glycosylation. Inflamm Bowel Dis. 2011;17:543-56 pubmed publisher
    ..We speculate that this may have physiological implication for gut defense. ..
  22. Kim H, Abd Elmageed Z, Davis C, El Bahrawy A, Naura A, Ekaidi I, et al. Correlation between PDZK1, Cdc37, Akt and breast cancer malignancy: the role of PDZK1 in cell growth through Akt stabilization by increasing and interacting with Cdc37. Mol Med. 2014;20:270-9 pubmed publisher
    ..by stabilizing the integrity of the growth promoting factors Akt, human epidermal growth factor receptor 2 (Her2/Neu) and EGFR. Increased Akt levels occurred via a decrease in the ubiquitination of the kinase...
  23. Kuznetsova M, Lopatnikova J, Khantakova J, Maksyutov R, Maksyutov A, Sennikov S. Generation of populations of antigen-specific cytotoxic T cells using DCs transfected with DNA construct encoding HER2/neu tumor antigen epitopes. BMC Immunol. 2017;18:31 pubmed publisher
    ..develop an optimized protocol for generating CTL populations specific for epitopes of tumor-associated antigen HER2/neu, and to assess their cytotoxic effects against the HER2/neu-expressing MCF-7 tumor cell line...
  24. Venereo Sanchez A, Gilbert R, Simoneau M, Caron A, Chahal P, Chen W, et al. Hemagglutinin and neuraminidase containing virus-like particles produced in HEK-293 suspension culture: An effective influenza vaccine candidate. Vaccine. 2016;34:3371-80 pubmed publisher
    ..These data suggest that, with further optimization and characterization the process could support mass production of safer and better-controlled VLPs-based influenza vaccine candidate. ..
  25. Hu C, Chien C, Liu M, Fang Z, Chang S, Juang R, et al. Multi-antigen avian influenza a (H7N9) virus-like particles: particulate characterizations and immunogenicity evaluation in murine and avian models. BMC Biotechnol. 2017;17:2 pubmed publisher
    ..The H7N9 VLPs possess desirable immunogenicity in vivo and may serve as a candidate for vaccine development against avian influenza A (H7N9) infection. ..
  26. Zhang X, Wang Q, Zhang J, Feng F, Wang F, Chen H, et al. Desialylation is associated with apoptosis and phagocytosis of platelets in patients with prolonged isolated thrombocytopenia after allo-HSCT. J Hematol Oncol. 2015;8:116 pubmed publisher
    ..The mechanisms participating in this process may include NEU1 translocation, platelet apoptosis, and phagocytosis by macrophages...
  27. Kim D, Son K, Koo K, Kim J, Alfajaro M, Park J, et al. Porcine Sapelovirus Uses α2,3-Linked Sialic Acid on GD1a Ganglioside as a Receptor. J Virol. 2016;90:4067-4077 pubmed publisher
    ..These findings should contribute to the understanding of the sapelovirus life cycle and to the development of affordable, useful and efficient drugs for anti-sapelovirus therapy. ..
  28. Zhao Y, Yang Z, Shang J, Huang W, Wang B, Wei X, et al. Effects of indole alkaloids from leaf of Alstonia scholaris on post-infectious cough in mice. J Ethnopharmacol. 2018;218:69-75 pubmed publisher
    ..Total white blood cells (WBC) and neutrophils (NEU) amounts in BALF were reduced obviously and the pathological damage of lung was also attenuated...
  29. Li H, Ruberu K, Karl T, Garner B. Cerebral Apolipoprotein-D Is Hypoglycosylated Compared to Peripheral Tissues and Is Variably Expressed in Mouse and Human Brain Regions. PLoS ONE. 2016;11:e0148238 pubmed publisher
  30. Jiang L, Changsom D, Lerdsamran H, Wiriyarat W, Masamae W, Noisumdaeng P, et al. Immunobiological properties of influenza A (H7N9) hemagglutinin and neuraminidase proteins. Arch Virol. 2016;161:2693-704 pubmed publisher
    ..Taken together, our data demonstrated immunobiological properties of recombinant HA and NA proteins that might be useful for vaccine development. ..
  31. Leneva I, Burtseva E, Yatsyshina S, Fedyakina I, Kirillova E, Selkova E, et al. Virus susceptibility and clinical effectiveness of anti-influenza drugs during the 2010-2011 influenza season in Russia. Int J Infect Dis. 2016;43:77-84 pubmed publisher
    ..001). This study provided experimental and clinical evidence of the efficacy of oseltamivir and umifenovir against influenza viruses, representatives of which have continued to circulate in post-pandemic seasons. ..
  32. Maggio B, Raimondi M, Raffa D, Plescia F, Scherrmann M, Prosa N, et al. Synthesis and antiproliferative activity of a natural like glycoconjugate polycyclic compound. Eur J Med Chem. 2016;122:247-256 pubmed publisher
    ..on MDA-MB231, a very aggressive breast cancer cell line, which does not express estrogen, progesterone and HER-2/neu receptors, showed that 4 is able to induce prolonged cell cycle arrest at G2/M phase and morphological signs of ..
  33. Wiggert N, Wilhelm F, Boger S, Georgii C, Klimesch W, Blechert J. Social Pavlovian conditioning: Short- and long-term effects and the role of anxiety and depressive symptoms. Soc Cogn Affect Neurosci. 2017;12:329-339 pubmed publisher
    ..underwent a classical conditioning task with videos of actors expressing disapproving (US-neg) or neutral (US-neu) statements...
  34. Shabbir A, Mirza T, Khalid A, Qureshi M, Asim S. Frequency of Her2/neu expression in colorectal adenocarcinoma: a study from developing South Asian Country. BMC Cancer. 2016;16:855 pubmed
    Human Epidermal Growth Factor (Her-2/neu) has strong therapeutic implications in certain cancers like breast and gastric cancer. Literature on its frequency in colorectal cancer is scarce...
  35. Vranic S, Feldman R, Gatalica Z. Apocrine carcinoma of the breast: A brief update on the molecular features and targetable biomarkers. Bosn J Basic Med Sci. 2017;17:9-11 pubmed publisher
    ..estrogen receptor-negative and androgen receptor-positive profile with a frequent overexpression of Her-2/neu protein (~30%)...
  36. Al Qahtani A, Mubin M, Dela Cruz D, AlThawadi S, Ul Rehman M, Bohol M, et al. Phylogenetic and nucleotide sequence analysis of influenza A (H1N1) HA and NA genes of strains isolated from Saudi Arabia. J Infect Dev Ctries. 2017;11:81-88 pubmed publisher
    ..The antigenic site of the HA gene had acquired novel mutations in some isolates, making continued monitoring of these viruses vital for the identification of potentially highly virulent and drug resistant variants. ..
  37. Chen D, Lee Y, Van Tine B, Searleman A, Westergard T, Liu H, et al. A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth. Cancer Res. 2012;72:736-46 pubmed publisher
    ..22 ?mol/L). In the MMTV-neu mouse model of breast cancer and the U251 xenograft model of brain cancer, NSC48300 produced effective tumor growth ..
  38. Tapmeier T, Moshnikova A, Beech J, Allen D, Kinchesh P, Smart S, et al. The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions. Proc Natl Acad Sci U S A. 2015;112:9710-5 pubmed publisher
    ..markers of low pH in tumor allografts and of malignant lesions in a mouse model of spontaneous breast cancer, BALB/neu-T...
  39. Shi H, Hong Y, Qian J, Cai X, Chen S. Xuebijing in the treatment of patients with sepsis. Am J Emerg Med. 2017;35:285-291 pubmed publisher
    ..03×109/L-[-0.94×109/L]), CRP (WMD: -24.38mg/L, 95%CI:-30.49mg/L-[-18.26mg/L]), NEU (WMD: -4.68, 95%CI: -8.32-[-1.04]), T0(WMD: -0.50, 95%CI: -0.92-[-0.07])...
  40. Hyun S, Liu A, Liu Z, Lillehoj E, Madri J, Reynolds A, et al. As human lung microvascular endothelia achieve confluence, src family kinases are activated, and tyrosine-phosphorylated p120 catenin physically couples NEU1 sialidase to CD31. Cell Signal. 2017;35:1-15 pubmed publisher
    In postconfluent human pulmonary microvascular endothelial cell (HPMEC)s, NEU1 sialidase associates with and desialylates the src family kinase (SFK) substrate, CD31, and disrupts angiogenesis...
  41. Khoury A, Parihar V, O steen L, Cherabuddi K. Pertuzumab and trastuzumab infusion related cytokine release syndrome in a chemotherapy naive patient with metastatic breast cancer. Breast J. 2017;: pubmed publisher
    Pertuzumab is a monoclonal antibody that targets and down regulates HER-2/neu expression in ductal breast tumors...
  42. Masuelli L, Granato M, Benvenuto M, Mattera R, Bernardini R, Mattei M, et al. Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice. Oncoimmunology. 2017;6:e1356151 pubmed publisher
    ..this study, we evaluated the in vitro and in vivo anti-cancer effect of curcumin (CUR) against Her2/neu overexpressing breast cancer cells (TUBO) in the presence or in the absence of the autophagy inhibitor chloroquine (..
  43. Lee C, Liu A, Miranda Ribera A, Hyun S, Lillehoj E, Cross A, et al. NEU1 sialidase regulates the sialylation state of CD31 and disrupts CD31-driven capillary-like tube formation in human lung microvascular endothelia. J Biol Chem. 2014;289:9121-35 pubmed publisher
    ..We recently established endothelial cell (EC) expression of NEU1 sialidase (Cross, A. S., Hyun, S. W., Miranda-Ribera, A., Feng, C., Liu, A., Nguyen, C., Zhang, L., Luzina, I. G...
  44. Pastor Soler N, Sutton T, Mang H, Kinlough C, Gendler S, Madsen C, et al. Muc1 is protective during kidney ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2015;308:F1452-62 pubmed publisher
    ..Moreover, our data support a role specifically for HIF-1 in epithelial protection of the kidney during IRI as Muc1 is present only in tubule epithelial cells. ..
  45. Bowers L, Wiese M, Brenner A, Rossi E, Tekmal R, Hursting S, et al. Obesity Suppresses Estrogen Receptor Beta Expression in Breast Cancer Cells via a HER2-Mediated Pathway. PLoS ONE. 2015;10:e0145452 pubmed publisher
    ..representing the major breast cancer subtypes (SKBR3, MCF-7, ZR75, MDA-MB-231) and mammary tumor cells from MMTV-neu mice were used...
  46. Costa R, Navalesi P, Cammarota G, Longhini F, Spinazzola G, Cipriani F, et al. Remifentanil effects on respiratory drive and timing during pressure support ventilation and neurally adjusted ventilatory assist. Respir Physiol Neurobiol. 2017;244:10-16 pubmed publisher
    ..1μg·Kg-1·min-1) during both PSV and NAVA. We measured the patient's (Ti/Ttotneu) and ventilator (Ti/Ttotmec) duty cycle, the Electrical Activity of the Diaphragm (EAdi), the ..
  47. Feki J, Fourati N, Mnif H, Khabir A, Toumi N, Khanfir A, et al. [Primary neuroendocrine tumors of the breast: a retrospective study of 21 cases and literature review]. Cancer Radiother. 2015;19:308-12 pubmed publisher
    ..5%) progesterone receptor-positive. Nineteen (90.5%) tumours were negative for HER2/neu. Overall five-year survival was 72.7%...
  48. Black J, Lopez S, Cocco E, Bellone S, Altwerger G, Schwab C, et al. PIK3CA oncogenic mutations represent a major mechanism of resistance to trastuzumab in HER2/neu overexpressing uterine serous carcinomas. Br J Cancer. 2015;113:1020-6 pubmed publisher
    We evaluated the role of PIK3CA-mutations as mechanism of resistance to trastuzumab in primary HER2/neu-amplified uterine-serous-carcinoma (USC) cell lines...
  49. Iranpour M, Soudyab M, Geranpayeh L, Mirfakhraie R, Azargashb E, Movafagh A, et al. Expression analysis of four long noncoding RNAs in breast cancer. Tumour Biol. 2016;37:2933-40 pubmed publisher
    ..clinical data such as tumor stage, grade, size and hormone receptor status except for ANRASSF1 expression and Her2/neu status. In addition, ANRASSF1 and ANRIL expressions were significantly higher in triple negative samples...
  50. Wagner Y, Heinrich Weltzien R. Evaluation of an interdisciplinary preventive programme for early childhood caries: findings of a regional German birth cohort study. Clin Oral Investig. 2016;20:1943-1952 pubmed
    ..German Clinical Trials Register DRKS00003438, https://drks-neu.uniklinik-freiburg.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00003438.
  51. Kobayashi M, Kodama M, Noshi T, Yoshida R, Kanazu T, Nomura N, et al. Therapeutic efficacy of peramivir against H5N1 highly pathogenic avian influenza viruses harboring the neuraminidase H275Y mutation. Antiviral Res. 2017;139:41-48 pubmed publisher
    ..These results suggest that peramivir has therapeutic activity against HPAI viruses even if the virus harbors the NA H275Y mutation. ..
  52. Calhan O, Seyrantepe V. Mice with Catalytically Inactive Cathepsin A Display Neurobehavioral Alterations. Behav Neurol. 2017;2017:4261873 pubmed publisher
    ..CathA protects ?-galactosidase and sialidase Neu1 against proteolytic degradation by forming a multienzyme complex and activates sialidase Neu1...
  53. Peters I, van der Steen M, Huisman B, Hilders C, Smit V, Vahrmeijer A, et al. Morphological and phenotypical features of ovarian metastases in breast cancer patients. BMC Cancer. 2017;17:206 pubmed publisher
    ..analyzed: E-cadherin, epithelial membrane antigen (EMA), human epidermal growth receptor type 2 (Her2/neu), carcinoembryonic antigen (CEA), ?v?6 integrin and epithelial cell adhesion molecule (EpCAM)...
  54. Hseu Y, Tsai T, Korivi M, Liu J, Chen H, Lin C, et al. Antitumor properties of Coenzyme Q0 against human ovarian carcinoma cells via induction of ROS-mediated apoptosis and cytoprotective autophagy. Sci Rep. 2017;7:8062 pubmed publisher
    ..Interestingly, CoQ0-induced apoptosis/autophagy is associated with suppression of HER-2/neu and PI3K/AKT signalling cascades...
  55. Zhao Z, Guo Z, Zhang C, Liu L, Chen L, Zhang C, et al. Avian Influenza H5N6 Viruses Exhibit Differing Pathogenicities and Transmissibilities in Mammals. Sci Rep. 2017;7:16280 pubmed publisher
    ..These results highlight the importance of monitoring the continual adaptation of H5N6 viruses in poultry due to their potential threat to human health. ..
  56. Odahara J, Miura A, Rosero Navarro N, Tadanaga K. Explosive Reaction for Barium Niobium Perovskite Oxynitride. Inorg Chem. 2017;: pubmed publisher
    An intense exothermic and explosive reaction between Ba(OH)2, NbCl5, and NaNH2 produced barium niobium perovskite oxynitride in seconds...
  57. Rossi E, Simoncini E, Valcamonico F, Marini G, Grigolato P, Dessy E. Different expression of HER2/neu oncogene in breast carcinoma and in liver metastasis. Description of a case. Tumori. 2006;92:536-9 pubmed
    ..High HER-2 protein expression assessed by immunohistochemistry and HER-2/neu amplification determined by FISH were present in the primary tumor, while the liver metastasis showed a lower value ..
  58. Kwon S, Zhang F, Dordick J, Sonstein W, Linhardt R. Detection of cerebrospinal fluid leakage by specific measurement of transferrin glycoforms. Electrophoresis. 2015;36:2425-32 pubmed publisher
    ..The new approach for selective removal of only sTF in test samples will be promising for the required intervention by a spine surgeon. ..
  59. Tsai A, McNeil C, Leeman J, Bennett H, Nti Addae K, Huang C, et al. Novel Ranking System for Identifying Efficacious Anti-Influenza Virus PB2 Inhibitors. Antimicrob Agents Chemother. 2015;59:6007-16 pubmed publisher
    ..The ability to identify compounds with enhanced preclinical properties provides an opportunity to develop more-effective treatments for influenza in patients. ..
  60. Bracken M, Hayes B, Kandel S, Scott Shemon D, Ackerson L, Hoffman M. Viral protein requirements for assembly and release of human parainfluenza virus type 3 virus-like particles. J Gen Virol. 2016;97:1305-1310 pubmed publisher
    ..These findings reinforce the central importance of the M protein in virus assembly and release, but also illustrate the variable roles of other paramyxovirus proteins during these processes. ..
  61. Garbe C, Eigentler T, Bauer J, Blödorn Schlicht N, Cerroni L, Fend F, et al. Mitoserate beim primären Melanom: Interobserver- und Intraobserver-Reproduzierbarkeit am HE-Schnitt und in der Immunhistologie. J Dtsch Dermatol Ges. 2016;14:910-6 pubmed publisher
    ..primärer Melanome wurde als dritte Größe neben Tumordicke und Ulzeration die Angabe der Mitoserate neu eingeführt...
  62. Lee Y, Jang Y, Seong B. Cell-cultured, live attenuated, X-31ca-based H5N1 pre-pandemic influenza vaccine. Virology. 2017;504:73-78 pubmed publisher
    ..Stable maintenance of attenuation phenotypes and immunogenicity of the rH5N1ca from cell-culture suggest that they can be produced as a stockpile for pandemic preparedness as an alternative to current egg-based production. ..
  63. Ou H, Yao W, Yu D, Weng T, Wang F, Wu X, et al. Longevity of protective immune responses induced by a split influenza A (H7N9) vaccine mixed with MF59 adjuvant in BALB/c mice. Oncotarget. 2017;8:91828-91840 pubmed publisher
    ..Therefore, the split H7N9 influenza vaccine with the MF59 adjuvant could effectively induce antibody production and protect mice from H7N9 virus challenge even after six months...
  64. Hashem A, Azhar E, Shalhoub S, Abujamel T, Othman N, Al Zahrani A, et al. Genetic characterization and diversity of circulating influenza A/H1N1pdm09 viruses isolated in Jeddah, Saudi Arabia between 2014 and 2015. Arch Virol. 2018;163:1219-1230 pubmed publisher
    ..Jeddah represents the main port of entry to the holy cities of Makkah and Al-Madinah, emphasizing the need for vigilant surveillance in the kingdom. ..
  65. Jiang J, Wen H, Chi M, Liu Y, Liu J, Cao Z, et al. Functional analysis of amino acids at stalk/head interface of human parainfluenza virus type 3 hemagglutinin-neuraminidase protein in the membrane fusion process. Virus Genes. 2018;54:333-342 pubmed publisher
    ..Moreover, I112A, D120A, and R122A mutations of the stalk region that were masked by global head in down position had influence on the interaction between F and HN proteins. ..
  66. Hiono T, Okamatsu M, Igarashi M, McBride R, de Vries R, Peng W, et al. Amino acid residues at positions 222 and 227 of the hemagglutinin together with the neuraminidase determine binding of H5 avian influenza viruses to sialyl Lewis X. Arch Virol. 2016;161:307-16 pubmed publisher
    ..The present results reveal the molecular basis of the interaction between fucosylated α2,3 sialosides and influenza viruses. ..
  67. Boechat F, Sacramento C, Cunha A, Sagrillo F, Nogueira C, Fintelman Rodrigues N, et al. 1,2,3-Triazolyl-4-oxoquinolines: A feasible beginning for promising chemical structures to inhibit oseltamivir-resistant influenza A and B viruses. Bioorg Med Chem. 2015;23:7777-84 pubmed publisher
    ..2μM with less cytotoxicity than OST, and also inhibited different OST-resistant NAs. These results suggest that 1,2,3-triazolyl-4-oxoquinolines represent promising lead molecules for further anti-influenza drug design. ..
  68. Sullivan S, Chow M, Barr I, Kelso A. Influenza viruses received and tested by the Melbourne WHO Collaborating Centre for Reference and Research on Influenza annual report, 2014. Commun Dis Intell Q Rep. 2015;39:E602-11 pubmed
    ..A total of 38 viruses were successfully isolated in eggs, of which 1 (B/Phuket/3073/2013) was included in the 2015 Southern Hemisphere influenza vaccine. ..
  69. Tran T, Diniz M, Dransart E, Gey A, Merillon N, Lone Y, et al. A Therapeutic Her2/neu Vaccine Targeting Dendritic Cells Preferentially Inhibits the Growth of Low Her2/neu-Expressing Tumor in HLA-A2 Transgenic Mice. Clin Cancer Res. 2016;22:4133-44 pubmed publisher
    E75, a peptide derived from the Her2/neu protein, is the most clinically advanced vaccine approach against breast cancer...
  70. Ellis P, Brufsky A, Beriwal S, Lokay K, Benson H, McCutcheon S, et al. Pathways Clinical Decision Support for Appropriate Use of Key Biomarkers. J Oncol Pract. 2016;12:e681-7 pubmed publisher
    ..retrospectively reviewed patients with estrogen receptor-positive, human epidermal growth factor receptor 2 (HER2)Neu-negative disease with zero to three positive nodes navigated in the Via Pathways decision support portal during a ..
  71. Zhu J, Hu S, Xu H, Liu J, Zhao Z, Wang X, et al. Characterization of virulent Newcastle disease viruses from vaccinated chicken flocks in Eastern China. BMC Vet Res. 2016;12:113 pubmed publisher
    ..Our findings indicated that the E347K variation in HN gene would expand the antigenic difference with LaSota, which may be responsible for the increasing isolation rate of these strains from vaccinated chickens. ..
  72. Hung I, To K, Chan J, Cheng V, Liu K, Tam A, et al. Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination in the Treatment of Patients Hospitalized for Influenza A(H3N2) Infection: An Open-label Randomized, Controlled, Phase IIb/III Trial. Chest. 2017;151:1069-1080 pubmed publisher
    ..Further study of the antiviral and immunomodulatory effects of this combination treatment of severe influenza is warranted. BioMed Central; No.: ISRCTN11273879 DOI 10.1186/ISRCTN11273879; URL: www.isrctn.com/ISRCTN11273879. ..
  73. Ciobanu Apostol D, Caruntu I, Lozneanu L, Andriescu E, Giuşcă S. HER-2÷neu expression in different histological subtypes of papillary thyroid carcinoma. Rom J Morphol Embryol. 2017;58:439-444 pubmed
    ..Our study aims to analyze the HER-2÷neu expression in different subtypes of PTC and its relationship with the classical clinicopathological factors...
  74. Mulinari S, Davis C. Why European and United States drug regulators are not speaking with one voice on anti-influenza drugs: regulatory review methodologies and the importance of 'deep' product reviews. Health Res Policy Syst. 2017;15:93 pubmed publisher
    ..Regulators use major resources to evaluate drugs, but if regulators' assessments are not effectively disseminated and used, resources are used inefficiently. ..
  75. Trombetta C, Perini D, Mather S, Temperton N, Montomoli E. Overview of Serological Techniques for Influenza Vaccine Evaluation: Past, Present and Future. Vaccines (Basel). 2014;2:707-34 pubmed publisher
  76. Acar E, Demir A, Alatas Ã, Beydilli H, Yıldırım B, Kırlı U, et al. Evaluation of hematological markers in minor head trauma in the emergency room. Eur J Trauma Emerg Surg. 2016;42:611-616 pubmed
    ..between the groups in terms of white blood cell (WBC), hemoglobin (Hb), mean platelet volume (MPV), neutrophil (neu), troponin T, neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR)...
  77. Anwar S, Wahyono A, Aryandono T, Haryono S. Caveolin-1 in Breast Cancer: Single Molecule Regulation of Multiple Key Signaling Pathways. Asian Pac J Cancer Prev. 2015;16:6803-12 pubmed
    ..Several pathways are modulated by Cav-1 including estrogen receptor, EGFR, Her2/neu, TGFβ, and mTOR and represent as major drivers in mammary carcinogenesis...
  78. Memoli M, Shaw P, Han A, Czajkowski L, Reed S, Athota R, et al. Evaluation of Antihemagglutinin and Antineuraminidase Antibodies as Correlates of Protection in an Influenza A/H1N1 Virus Healthy Human Challenge Model. MBio. 2016;7:e00417-16 pubmed publisher
    ..This is the first time NAI titer has been clearly identified in a controlled trial of this type to be an independent predictor of a reduction in all aspects of influenza. ..
  79. Love R. On the road to precision, there is more practical medicine to be implemented. Breast. 2016;29:188-91 pubmed publisher
    ..When ER and PR quantitative intensity and prevalence scoring is combined with Her-2/neu testing and careful tumor histologic grading, luminal A and B type tumors can be well-defined and gene-expression ..
  80. Adu Gyamfi E, Kim L, Jardetzky T, Lamb R. Flexibility of the Head-Stalk Linker Domain of Paramyxovirus HN Glycoprotein Is Essential for Triggering Virus Fusion. J Virol. 2016;90:9172-81 pubmed publisher
    ..Specifically, our data strongly support the notion that the short linker between the head and stalk plays a role in "conformational switching" of the head group to facilitate F-HN interaction and triggering. ..
  81. Boonnak K, Matsuoka Y, Wang W, Suguitan A, Chen Z, Paskel M, et al. Development of Clade-Specific and Broadly Reactive Live Attenuated Influenza Virus Vaccines against Rapidly Evolving H5 Subtype Viruses. J Virol. 2017;91: pubmed publisher
    ..Our study permits a comparison of the two approaches, and the data support the further development of both vaccine viruses to optimally prepare for the further spread of clade 2.2.1 or 2.3.4.4 viruses. ..
  82. Santos López G, Borraz Argüello M, Márquez Domínguez L, Flores Alonso J, Ramírez Mendoza H, Priem B, et al. Neuraminidase activity of blue eye disease porcine rubulavirus: Specificity, affinity and inhibition studies. Res Vet Sci. 2017;114:218-224 pubmed publisher
    ..The present results open possibilities to study the role of neuraminidase in the pathogenicity of PorPV infection and its potential inhibitors. ..
  83. Phan S, Zengel J, Wei H, Li Z, Wang D, He B. Parainfluenza Virus 5 Expressing Wild-Type or Prefusion Respiratory Syncytial Virus (RSV) Fusion Protein Protects Mice and Cotton Rats from RSV Challenge. J Virol. 2017;91: pubmed publisher
    ..Most importantly, we found that PIV5-based RSV vaccine candidates were efficacious in preventing lower respiratory tract infection as well as in reducing the nasal viral load when administered via the subcutaneous route. ..
  84. Luftner D, Cheli C, Mickelson K, Sampson E, Possinger K. ADVIA Centaur HER-2/neu shows value in monitoring patients with metastatic breast cancer. Int J Biol Markers. 2004;19:175-82 pubmed
    The proteolytic breakdown product corresponding to the extracellular domain (ECD) of the HER-2/neu oncoprotein p185 is found in the circulation of healthy individuals and patients having cancers of epithelial origin...
  85. Tatano Y, Takeuchi N, Kuwahara J, Sakuraba H, Takahashi T, Takada G, et al. Elastogenesis in cultured dermal fibroblasts from patients with lysosomal beta-galactosidase, protective protein/cathepsin A and neuraminidase-1 deficiencies. J Med Invest. 2006;53:103-12 pubmed
    ..Defect of the EBP as a chaperon for tropoelastin and a component of receptor complex among neuraminidase-1 (NEU1) and protective protein/cathepsin A (PPCA) is suggested responsible for impaired elastogenesis in autosomal ..
  86. Guo L, Abraham J, Flynn D, Castranova V, Shi X, Qian Y. Individualized survival and treatment response predictions for breast cancers using phospho-EGFR, phospho-ER, phospho-HER2/neu, phospho-IGF-IR/In, phospho-MAPK, and phospho-p70S6K proteins. Int J Biol Markers. 2007;22:1-11 pubmed
    ..individual breast cancer patients with the use of the expression profiles of phospho-EGFR, phospho-ER, phospho-HER2/neu, phospho-IGFIR/In, phospho-MAPK, and phospho-p70S6K plus the selected clinical factors...
  87. Marty F, Vidal Puigserver J, Clark C, Gupta S, Merino E, Garot D, et al. Intravenous zanamivir or oral oseltamivir for hospitalised patients with influenza: an international, randomised, double-blind, double-dummy, phase 3 trial. Lancet Respir Med. 2017;5:135-146 pubmed publisher
    ..All treatments had a similar safety profile in hospitalised patients with severe influenza. GlaxoSmithKline. ..
  88. Prabhu V, Devaraj N. Epidermal Growth Factor Receptor Tyrosine Kinase: A Potential Target in Treatment of Non-Small-Cell Lung Carcinoma. J Environ Pathol Toxicol Oncol. 2017;36:151-158 pubmed publisher
    ..a receptor tyrosine kinase of the ErbB family, which consists of four closely related receptors: HER-1/ErbB1, HER-2/neu/ErbB2, HER-3/ErbB3, and HER-4/ErbB4...
  89. Hus Y. Issues in Identification and Assessment of Children with Autism and a Proposed Resource Toolkit for Speech-Language Pathologists. Folia Phoniatr Logop. 2017;69:27-37 pubmed publisher
    ..topic includes issues related to naming, description, iden-tification, assessment, and differentiation from other neu-rodevelopmental conditions...
  90. Zerega B, Cermelli S, Michelis B, Cancedda R, Cancedda F. Expression of NRL/NGAL (neu-related lipocalin/neutrophil gelatinase-associated lipocalin) during mammalian embryonic development and in inflammation. Eur J Cell Biol. 2000;79:165-72 pubmed
    The neu-related lipocalin (NRL) is a protein overexpressed in rat mammary cancer induced by activated neu (HER-2/c-erbB2)...
  91. Uemura T, Shiozaki K, Yamaguchi K, Miyazaki S, Satomi S, Kato K, et al. Contribution of sialidase NEU1 to suppression of metastasis of human colon cancer cells through desialylation of integrin beta4. Oncogene. 2009;28:1218-29 pubmed publisher
    We previously found an inverse relationship between sialidase Neu1 expression and metastatic potential of murine cancer cells...
  92. Yasinzai M. Quantitation of the cancer marker LASA using immobilized enzymes in a semiautomated system. Int J Biol Markers. 2009;24:107-11 pubmed
    ..We observed no loss of activity of the immobilized enzymes after analyzing about 300 samples. The sample throughput was 30 samples per hour...